TY  - JOUR
AU  - Srebro, Dragana P.
AU  - Vucković, Sonja M.
AU  - Dožić, Ivan
AU  - Dožić, Branko
AU  - Savić-Vujović, Katarina R.
AU  - Milovanović, Aleksandar P.
AU  - Karadžić, Branislav
AU  - Prostran, Milica S.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2315
AB  - Background: In humans, orofacial pain has a high prevalence and is often difficult to treat. Magnesium is an essential element in biological a system which controls the activity of many ion channels, neurotransmitters and enzymes. Magnesium produces an antinociceptive effect in neuropathic pain, while in inflammatory pain results are not consistent. We examined the effects of magnesium sulfate using the rat orofacial formalin test, a model of trigeminal pain. Methods: Male Wistar rats were injected with 1.5% formalin into the perinasal area, and the total time spent in pain-related behavior (face rubbing) was quantified. We also spectrophotometrically determined the concentration of magnesium and creatine kinase activity in blood serum. Results: Magnesium sulfate administered subcutaneously (0.005-45 mg/kg) produced significant antinociception in the second phase of the orofacial formalin test in rats at physiological serum concentration of magnesium. The effect was not dose-dependent. The maximum antinociceptive effect of magnesium sulfate was about 50% and was achieved at doses of 15 and 45 mg/kg. Magnesium did not affect increase the levels of serum creatine kinase activity. Conclusions: Preemptive systemic administration of magnesium sulfate as the only drug can be used to prevent inflammatory pain in the orofacial region. Its analgesic effect is not associated with magnesium deficiency.
PB  - Polish Acad Sciences Inst Pharmacology, Krakow
T2  - Pharmacological Reports
T1  - Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels
VL  - 70
IS  - 1
SP  - 81
EP  - 86
DO  - 10.1016/j.pharep.2017.08.005
ER  - 

@article{
author = "Srebro, Dragana P. and Vucković, Sonja M. and Dožić, Ivan and Dožić, Branko and Savić-Vujović, Katarina R. and Milovanović, Aleksandar P. and Karadžić, Branislav and Prostran, Milica S.",
year = "2018",
abstract = "Background: In humans, orofacial pain has a high prevalence and is often difficult to treat. Magnesium is an essential element in biological a system which controls the activity of many ion channels, neurotransmitters and enzymes. Magnesium produces an antinociceptive effect in neuropathic pain, while in inflammatory pain results are not consistent. We examined the effects of magnesium sulfate using the rat orofacial formalin test, a model of trigeminal pain. Methods: Male Wistar rats were injected with 1.5% formalin into the perinasal area, and the total time spent in pain-related behavior (face rubbing) was quantified. We also spectrophotometrically determined the concentration of magnesium and creatine kinase activity in blood serum. Results: Magnesium sulfate administered subcutaneously (0.005-45 mg/kg) produced significant antinociception in the second phase of the orofacial formalin test in rats at physiological serum concentration of magnesium. The effect was not dose-dependent. The maximum antinociceptive effect of magnesium sulfate was about 50% and was achieved at doses of 15 and 45 mg/kg. Magnesium did not affect increase the levels of serum creatine kinase activity. Conclusions: Preemptive systemic administration of magnesium sulfate as the only drug can be used to prevent inflammatory pain in the orofacial region. Its analgesic effect is not associated with magnesium deficiency.",
publisher = "Polish Acad Sciences Inst Pharmacology, Krakow",
journal = "Pharmacological Reports",
title = "Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels",
volume = "70",
number = "1",
pages = "81-86",
doi = "10.1016/j.pharep.2017.08.005"
}

Srebro, D. P., Vucković, S. M., Dožić, I., Dožić, B., Savić-Vujović, K. R., Milovanović, A. P., Karadžić, B.,& Prostran, M. S.. (2018). Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. in Pharmacological Reports
Polish Acad Sciences Inst Pharmacology, Krakow., 70(1), 81-86.
https://doi.org/10.1016/j.pharep.2017.08.005

Srebro DP, Vucković SM, Dožić I, Dožić B, Savić-Vujović KR, Milovanović AP, Karadžić B, Prostran MS. Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. in Pharmacological Reports. 2018;70(1):81-86.
doi:10.1016/j.pharep.2017.08.005 .

Srebro, Dragana P., Vucković, Sonja M., Dožić, Ivan, Dožić, Branko, Savić-Vujović, Katarina R., Milovanović, Aleksandar P., Karadžić, Branislav, Prostran, Milica S., "Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels" in Pharmacological Reports, 70, no. 1 (2018):81-86,
https://doi.org/10.1016/j.pharep.2017.08.005 . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Prostran, Milica S.
AU  - Naumović, R.
AU  - Simić-Ogrizović, Sanja
AU  - Radojević-Škodrić, Sanja
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2094
AB  - Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation
VL  - 23
IS  - 19
SP  - 2012
EP  - 2017
DO  - 10.2174/092986732319160719192019
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Bogdanović, Ljiljana and Radunović, Milena and Prostran, Milica S. and Naumović, R. and Simić-Ogrizović, Sanja and Radojević-Škodrić, Sanja",
year = "2016",
abstract = "Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation",
volume = "23",
number = "19",
pages = "2012-2017",
doi = "10.2174/092986732319160719192019"
}

Basta-Jovanović, G., Bogdanović, L., Radunović, M., Prostran, M. S., Naumović, R., Simić-Ogrizović, S.,& Radojević-Škodrić, S.. (2016). Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 23(19), 2012-2017.
https://doi.org/10.2174/092986732319160719192019

Basta-Jovanović G, Bogdanović L, Radunović M, Prostran MS, Naumović R, Simić-Ogrizović S, Radojević-Škodrić S. Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry. 2016;23(19):2012-2017.
doi:10.2174/092986732319160719192019 .

Basta-Jovanović, Gordana, Bogdanović, Ljiljana, Radunović, Milena, Prostran, Milica S., Naumović, R., Simić-Ogrizović, Sanja, Radojević-Škodrić, Sanja, "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation" in Current Medicinal Chemistry, 23, no. 19 (2016):2012-2017,
https://doi.org/10.2174/092986732319160719192019 . .