TY  - JOUR
AU  - Bijelić, Borivoj
AU  - Matić, Ivana Z.
AU  - Besu, Irina
AU  - Janković, Ljiljana
AU  - Juranić, Zorica
AU  - Marusić, Senka
AU  - Andrejević, Slađana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2456
AB  - The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadinanalogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p  lt  0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease.
PB  - Elsevier Gmbh, Munich
T2  - Immunobiology
T1  - Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis
VL  - 224
IS  - 1
SP  - 75
EP  - 79
DO  - 10.1016/j.imbio.2018.10.006
ER  - 

@article{
author = "Bijelić, Borivoj and Matić, Ivana Z. and Besu, Irina and Janković, Ljiljana and Juranić, Zorica and Marusić, Senka and Andrejević, Slađana",
year = "2019",
abstract = "The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadinanalogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p  lt  0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease.",
publisher = "Elsevier Gmbh, Munich",
journal = "Immunobiology",
title = "Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis",
volume = "224",
number = "1",
pages = "75-79",
doi = "10.1016/j.imbio.2018.10.006"
}

Bijelić, B., Matić, I. Z., Besu, I., Janković, L., Juranić, Z., Marusić, S.,& Andrejević, S.. (2019). Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. in Immunobiology
Elsevier Gmbh, Munich., 224(1), 75-79.
https://doi.org/10.1016/j.imbio.2018.10.006

Bijelić B, Matić IZ, Besu I, Janković L, Juranić Z, Marusić S, Andrejević S. Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. in Immunobiology. 2019;224(1):75-79.
doi:10.1016/j.imbio.2018.10.006 .

Bijelić, Borivoj, Matić, Ivana Z., Besu, Irina, Janković, Ljiljana, Juranić, Zorica, Marusić, Senka, Andrejević, Slađana, "Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis" in Immunobiology, 224, no. 1 (2019):75-79,
https://doi.org/10.1016/j.imbio.2018.10.006 . .

TY  - THES
AU  - Bijelić, Borivoj
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5603
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:17132/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49850383
UR  - http://nardus.mpn.gov.rs/123456789/9250
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1023
AB  - Humoral immunity as a part of an adaptive immune response is primary represented by B lymphocytes which differentiate into plasma cells, able to secrete antibodies, which are basic efector mechanism of humoral immunity. Alterations in antibody production has been observed in patients with different immune-inflammatory conditions including recurrent oral ulcerations (ROU), gluten sensitive enteropathy (GSE) and inflammatory bowel disease (IBD). Recurrent oral ulcerations represents an inflammatory disease characterized by appearance of repeated episodes of solitary or multiple painfully ulcerations of oral mucosa, affecting about 20% of the general population. Precise etiology of recurrent oral ulcerations is still unknown but it is proven that numerous etiological factors like heritage, stress, trauma, hypersensitivity to the food components, nutritional deficiency and hormonal imbalance, have important role in their occurrence. Gluten sensitive enteropathy or celiac disease (CeD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. GSE can be presented with classical gastrointestinal symptoms but also as an atypical, silent and latent form with a wide spectrum of non-gastrointestinal symptoms. In recent years, antibodies against native gliadin (GL), tissue transglutaminase (tTG), deaminated gliadin peptides (DGP) and deaminated gliadin analogous fragments (GAF) play a key role in early diagnosis. Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases with primary intestinal involvement. IBD patients may exhibit a wide range of non-intestinal signs and symptoms, among which ROU is classified as well. Serologic markers for UC and CD are antineutrophil cytoplasmic antibodies (ANCA) and antibodies against Saccharomyces cerevisiae (ASCA) respectively. Modifications in oral tolerance, mucosal immunity and in epithelial barrier functionality observed in GSE, IBC and food allergens hypersensitivity, could also influence occurrence of ROU...
AB  - Humoralni imunitet predstavlja deo adaptivnog imunskog odgovora i sačinjavaju ga prevashodno B limfociti, čijom aktivacijom nastaju plazmociti, sposobni da produkuju antitela koja ujedno predstavljaju osnovni efektorski mehanizam humoralnog imuniteta. Poremećaj u produkciji antitela uočen je kod pacijenata sa različitim imuno-inflamatornim stanjima, u koja se svrstavaju i rekurentne oralne ulceracije (ROU), gluten senzitivna enteropatija (GSE) i inflamatorne bolesti creva (IBC). Rekurentne oralne ulceracije predstavljaju inflamantorno oboljenje koje se karakteriše pojavom ponavljanih epizoda solitarnih ili multiplih, bolnih ulceracija oralne sluzokože. One se javljaju u oko 20% opšte populacije. Precizna etiologija rekurentnih oralnih ulceracija je i dalje nepoznata, ali je dokazano da brojni etiološki faktori u koje se svrstavaju nasleđe, stres, trauma, preosetljivost na komponente hrane, nutritivni deficit i hormonski disbalans imaju značajnu ulogu u njihovom nastanku. Gluten senzitivna enteropatija ili celijačna bolest (CD) je imuno-posredovano oboljenje koje se javlja kod genetski predisponiranih osoba, izazvano unosom glutena, proteina koji se nalazi u mnogim žitaricama. Klinički se ispoljava klasičnim gastrointestinalnim simptomima, ali se može javiti i kao atipična, pritajena ili latentna forma kada je postavljanje dijagnoze GSE značajno otežano. Poslednjih godina, značajnu ulogu u dijagnostici imaju i antitela specifična za GSE kao što su antitela na nativni glijadin (GL), antitela specifična za tkivnu transglutaminazu (tTG), antitela specifična za deaminirane glijadinske peptide (DGP) i antitela specifična za fuzione peptide, glijadinske analoge (GAF-3X). Inflamatorne bolesti creva su imunski-posredovana, hronična, recidivirajuća oboljenja predstavljena kroz dve osnovne kliničke forme: Kronovu bolest (KB) i ulcerozni kolitis (UK). Pacijenti oboleli od IBC mogu imati širok spektar vancrevnih simptoma među koje se svrstavaju i oralne ulceracije. Kao pomoćni markeri u dijagnostici IBC koriste se antitela specifična za Saccharomyces cervisiae (ASCA) i antitela specifična za citoplazmatske antigene neutrofilnih leukocita (ANCA)...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Specificity of humoral immune responses in patients with recurrent oral ulcerations
T1  - Specifičnosti humoralne imunosti kod obolelih od rekurentnih oralnih ulceracija
UR  - https://hdl.handle.net/21.15107/rcub_nardus_9250
ER  - 

@phdthesis{
author = "Bijelić, Borivoj",
year = "2017",
abstract = "Humoral immunity as a part of an adaptive immune response is primary represented by B lymphocytes which differentiate into plasma cells, able to secrete antibodies, which are basic efector mechanism of humoral immunity. Alterations in antibody production has been observed in patients with different immune-inflammatory conditions including recurrent oral ulcerations (ROU), gluten sensitive enteropathy (GSE) and inflammatory bowel disease (IBD). Recurrent oral ulcerations represents an inflammatory disease characterized by appearance of repeated episodes of solitary or multiple painfully ulcerations of oral mucosa, affecting about 20% of the general population. Precise etiology of recurrent oral ulcerations is still unknown but it is proven that numerous etiological factors like heritage, stress, trauma, hypersensitivity to the food components, nutritional deficiency and hormonal imbalance, have important role in their occurrence. Gluten sensitive enteropathy or celiac disease (CeD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. GSE can be presented with classical gastrointestinal symptoms but also as an atypical, silent and latent form with a wide spectrum of non-gastrointestinal symptoms. In recent years, antibodies against native gliadin (GL), tissue transglutaminase (tTG), deaminated gliadin peptides (DGP) and deaminated gliadin analogous fragments (GAF) play a key role in early diagnosis. Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases with primary intestinal involvement. IBD patients may exhibit a wide range of non-intestinal signs and symptoms, among which ROU is classified as well. Serologic markers for UC and CD are antineutrophil cytoplasmic antibodies (ANCA) and antibodies against Saccharomyces cerevisiae (ASCA) respectively. Modifications in oral tolerance, mucosal immunity and in epithelial barrier functionality observed in GSE, IBC and food allergens hypersensitivity, could also influence occurrence of ROU..., Humoralni imunitet predstavlja deo adaptivnog imunskog odgovora i sačinjavaju ga prevashodno B limfociti, čijom aktivacijom nastaju plazmociti, sposobni da produkuju antitela koja ujedno predstavljaju osnovni efektorski mehanizam humoralnog imuniteta. Poremećaj u produkciji antitela uočen je kod pacijenata sa različitim imuno-inflamatornim stanjima, u koja se svrstavaju i rekurentne oralne ulceracije (ROU), gluten senzitivna enteropatija (GSE) i inflamatorne bolesti creva (IBC). Rekurentne oralne ulceracije predstavljaju inflamantorno oboljenje koje se karakteriše pojavom ponavljanih epizoda solitarnih ili multiplih, bolnih ulceracija oralne sluzokože. One se javljaju u oko 20% opšte populacije. Precizna etiologija rekurentnih oralnih ulceracija je i dalje nepoznata, ali je dokazano da brojni etiološki faktori u koje se svrstavaju nasleđe, stres, trauma, preosetljivost na komponente hrane, nutritivni deficit i hormonski disbalans imaju značajnu ulogu u njihovom nastanku. Gluten senzitivna enteropatija ili celijačna bolest (CD) je imuno-posredovano oboljenje koje se javlja kod genetski predisponiranih osoba, izazvano unosom glutena, proteina koji se nalazi u mnogim žitaricama. Klinički se ispoljava klasičnim gastrointestinalnim simptomima, ali se može javiti i kao atipična, pritajena ili latentna forma kada je postavljanje dijagnoze GSE značajno otežano. Poslednjih godina, značajnu ulogu u dijagnostici imaju i antitela specifična za GSE kao što su antitela na nativni glijadin (GL), antitela specifična za tkivnu transglutaminazu (tTG), antitela specifična za deaminirane glijadinske peptide (DGP) i antitela specifična za fuzione peptide, glijadinske analoge (GAF-3X). Inflamatorne bolesti creva su imunski-posredovana, hronična, recidivirajuća oboljenja predstavljena kroz dve osnovne kliničke forme: Kronovu bolest (KB) i ulcerozni kolitis (UK). Pacijenti oboleli od IBC mogu imati širok spektar vancrevnih simptoma među koje se svrstavaju i oralne ulceracije. Kao pomoćni markeri u dijagnostici IBC koriste se antitela specifična za Saccharomyces cervisiae (ASCA) i antitela specifična za citoplazmatske antigene neutrofilnih leukocita (ANCA)...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Specificity of humoral immune responses in patients with recurrent oral ulcerations, Specifičnosti humoralne imunosti kod obolelih od rekurentnih oralnih ulceracija",
url = "https://hdl.handle.net/21.15107/rcub_nardus_9250"
}

Bijelić, B.. (2017). Specificity of humoral immune responses in patients with recurrent oral ulcerations. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_9250

Bijelić B. Specificity of humoral immune responses in patients with recurrent oral ulcerations. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_9250 .

Bijelić, Borivoj, "Specificity of humoral immune responses in patients with recurrent oral ulcerations" (2017),
https://hdl.handle.net/21.15107/rcub_nardus_9250 .