TY  - JOUR
AU  - Bijelić, Borivoj
AU  - Matić, Ivana Z.
AU  - Besu, Irina
AU  - Janković, Ljiljana
AU  - Juranić, Zorica
AU  - Marusić, Senka
AU  - Andrejević, Slađana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2456
AB  - The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadinanalogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p  lt  0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease.
PB  - Elsevier Gmbh, Munich
T2  - Immunobiology
T1  - Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis
VL  - 224
IS  - 1
SP  - 75
EP  - 79
DO  - 10.1016/j.imbio.2018.10.006
ER  - 

@article{
author = "Bijelić, Borivoj and Matić, Ivana Z. and Besu, Irina and Janković, Ljiljana and Juranić, Zorica and Marusić, Senka and Andrejević, Slađana",
year = "2019",
abstract = "The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Antibodies against tissue transglutaminase (anti-tTG), deaminated gliadin peptides (DGP), deaminated gliadinanalogous fragments (anti-GAF-3X) and Saccharomyces cerevisiae (ASCA) were determined by ELISA and anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunoflurescence (IIF) in 57 patients with RAS and 60 control subjects. The prevalence of CeD specific antibodies did not differ between RAS patients and controls. However, the concentrations of IgA anti-tTG, IgA anti-GAF-3X antibodies in patients with RAS were significantly higher compared to controls (p = 0.002 and p = 0.04 respectively). Histological changes consistent with CeD were confirmed by duodenal biopsy in one RAS patient with highly positive IgA anti-tTG, anti-GAF-3X and anti-DGP antibodies. Higher prevalence along with higher concentrations of IgG ASCA were found in RAS patients compared to controls (p  lt  0.01). Patients with positive IgG ASCA in the absence of clinical symptoms decided not to pursue any further testing. Dysfunction of oral mucosa and the exposure to various antigens might be a reason for the loss of tolerance resulting in increased production of autoantibodies. It seems likely that antibodies are markers of aberrant immune response, rather than key effectors involved in the pathogenesis of the disease.",
publisher = "Elsevier Gmbh, Munich",
journal = "Immunobiology",
title = "Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis",
volume = "224",
number = "1",
pages = "75-79",
doi = "10.1016/j.imbio.2018.10.006"
}

Bijelić, B., Matić, I. Z., Besu, I., Janković, L., Juranić, Z., Marusić, S.,& Andrejević, S.. (2019). Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. in Immunobiology
Elsevier Gmbh, Munich., 224(1), 75-79.
https://doi.org/10.1016/j.imbio.2018.10.006

Bijelić B, Matić IZ, Besu I, Janković L, Juranić Z, Marusić S, Andrejević S. Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis. in Immunobiology. 2019;224(1):75-79.
doi:10.1016/j.imbio.2018.10.006 .

Bijelić, Borivoj, Matić, Ivana Z., Besu, Irina, Janković, Ljiljana, Juranić, Zorica, Marusić, Senka, Andrejević, Slađana, "Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis" in Immunobiology, 224, no. 1 (2019):75-79,
https://doi.org/10.1016/j.imbio.2018.10.006 . .