TY  - JOUR
AU  - Popovac, Aleksandra
AU  - Mladenović, Irena
AU  - Krunić, Jelena
AU  - Trifković, Branka
AU  - Todorović, Ana
AU  - Milašin, Jelena
AU  - Despotović, Nebojša
AU  - Stančić, Ivica
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2517
AB  - Compromised dentition has been suggested to pose a significant risk factor for dementia. It was mainly investigated through insufficient tooth number, disregarding contact between opposing teeth (dental occlusion). The epsilon 4 allele of apolipoprotein (APOE4) is the primary genetic marker for the late onset of Alzheimer's disease (AD). However, APOE4 and dental occlusion have not yet been investigated as possible associated risk factors for AD. The study was aimed to examine the impact of dental status and different APOE gene variants on AD occurrence. Secondly, sociodemographic variables were investigated as factors potentially associated with AD. The case-control study included two groups: 116 patients with AD (according to the NINDS-ADRDA criteria) and 63 controls (Mini-Mental State Examination scores >= 24). The analysis of APOE gene polymorphism was conducted through PCR reaction. Dental examination included recording of number of teeth, presence of fixed or removable dentures, and number of functional tooth units (FTU). Regression analysis was used to investigate the joint effect of the clinical and genetic variables on AD. Results showed that patients with AD were more often carriers of epsilon 3/epsilon 4 genotype and epsilon 4 allele, had lower number of teeth and FTU, and were less likely to be married, live in home, and had less chronic diseases, compared to the controls. Regression analysis showed that presence of APOE4 allele and the number of total FTU remained associated with AD, even when adjusted for age, sex, and level of education. In conclusion, deficient dental occlusion and presence of APOE4 may independently increase risk for AD.
PB  - Ios Press, Amsterdam
T2  - Journal of Alzheimers Disease
T1  - Apolipoprotein epsilon 4 Allele and Dental Occlusion Deficiency as Risk Factors for Alzheimer's Disease
VL  - 74
IS  - 3
SP  - 797
EP  - 802
DO  - 10.3233/JAD-191283
ER  - 

@article{
author = "Popovac, Aleksandra and Mladenović, Irena and Krunić, Jelena and Trifković, Branka and Todorović, Ana and Milašin, Jelena and Despotović, Nebojša and Stančić, Ivica",
year = "2020",
abstract = "Compromised dentition has been suggested to pose a significant risk factor for dementia. It was mainly investigated through insufficient tooth number, disregarding contact between opposing teeth (dental occlusion). The epsilon 4 allele of apolipoprotein (APOE4) is the primary genetic marker for the late onset of Alzheimer's disease (AD). However, APOE4 and dental occlusion have not yet been investigated as possible associated risk factors for AD. The study was aimed to examine the impact of dental status and different APOE gene variants on AD occurrence. Secondly, sociodemographic variables were investigated as factors potentially associated with AD. The case-control study included two groups: 116 patients with AD (according to the NINDS-ADRDA criteria) and 63 controls (Mini-Mental State Examination scores >= 24). The analysis of APOE gene polymorphism was conducted through PCR reaction. Dental examination included recording of number of teeth, presence of fixed or removable dentures, and number of functional tooth units (FTU). Regression analysis was used to investigate the joint effect of the clinical and genetic variables on AD. Results showed that patients with AD were more often carriers of epsilon 3/epsilon 4 genotype and epsilon 4 allele, had lower number of teeth and FTU, and were less likely to be married, live in home, and had less chronic diseases, compared to the controls. Regression analysis showed that presence of APOE4 allele and the number of total FTU remained associated with AD, even when adjusted for age, sex, and level of education. In conclusion, deficient dental occlusion and presence of APOE4 may independently increase risk for AD.",
publisher = "Ios Press, Amsterdam",
journal = "Journal of Alzheimers Disease",
title = "Apolipoprotein epsilon 4 Allele and Dental Occlusion Deficiency as Risk Factors for Alzheimer's Disease",
volume = "74",
number = "3",
pages = "797-802",
doi = "10.3233/JAD-191283"
}

Popovac, A., Mladenović, I., Krunić, J., Trifković, B., Todorović, A., Milašin, J., Despotović, N.,& Stančić, I.. (2020). Apolipoprotein epsilon 4 Allele and Dental Occlusion Deficiency as Risk Factors for Alzheimer's Disease. in Journal of Alzheimers Disease
Ios Press, Amsterdam., 74(3), 797-802.
https://doi.org/10.3233/JAD-191283

Popovac A, Mladenović I, Krunić J, Trifković B, Todorović A, Milašin J, Despotović N, Stančić I. Apolipoprotein epsilon 4 Allele and Dental Occlusion Deficiency as Risk Factors for Alzheimer's Disease. in Journal of Alzheimers Disease. 2020;74(3):797-802.
doi:10.3233/JAD-191283 .

Popovac, Aleksandra, Mladenović, Irena, Krunić, Jelena, Trifković, Branka, Todorović, Ana, Milašin, Jelena, Despotović, Nebojša, Stančić, Ivica, "Apolipoprotein epsilon 4 Allele and Dental Occlusion Deficiency as Risk Factors for Alzheimer's Disease" in Journal of Alzheimers Disease, 74, no. 3 (2020):797-802,
https://doi.org/10.3233/JAD-191283 . .

TY  - JOUR
AU  - Popovac, Aleksandra
AU  - Stančić, Ivica
AU  - Vuković, Ana
AU  - Despotović, Nebojša
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2277
AB  - Introduction. The growing population of the elderly people and a proportional increase in the number of the elderly with different types of disabilities, necessitates a multidisciplinary approach to the assessment of their oral health and dental treatment. The ultimate aim is to retain a pain-free functional dentition and decrease the risk of future disease. Material and Methods. A PubMed search was performed and the authors contributed their experience in implementing preventive and therapeutic measures. Oral health problems of the elderly with disabilities. Two main factors influence the oral health: multimorbidity and polypharmacy. Oral health problems expected in this population are teeth abrasion, teeth fractures, root caries, periodontitis and problems with wearing dentures due to stomatitis caused by Candida albicans. Oral health assessment and treatment guidelines. This article provides guidelines for assessment and treatment planning, taking into consideration multimorbidity, polypharmacy, dementia and capacity of caregivers. Preventive measures. Preventive measures are crucial for long-term oral health of this population, and this paper provides guidelines for preventive treatment depending on the degree of functional dependence. Prosthetic treatment. Although some elderly with disabilities are suitable for conventional prosthetic treatment, often there are contraindications and specific considerations that must be taken into account. Conclusion. Oral health needs of the elderly people with disabilities should not be neglected and the success of treatment depends on the education of dental professionals and cooperation with other health professionals of the medical team.
AB  - Uvod. Zbog rastuće populacije starih ljudi i proporcionalnog povećanja učestalosti broja starih ljudi sa različitim tipovima hendikepa, multi disciplinarni pristup proceni njihovog oralnog zdravlja je neophodan. Krajnji cilj je postići funkcionalnu denticiju bez bolova i smanjiti rizik od budućih oboljenja. Materijal i metode. Pretraživanje literature u bazi PubMed je obavljeno, ali je takođe iskustvo autora u primeni preventivnih i terapijskih mera uzeto u obzir. Problemi oralnog zdravlja starih ljudi sa hendikepom. Dva glavna razloga imaju uticaj na oralno zdravlje: multi morbiditet i polifarmacija. Problemi oralnog zdravlja koji se očekuju u ovoj populaciji su abrazija zuba, frakture zuba, karijes korena, parodontopatija i problemi sa nošenjem proteza usled stomatitis uzrokovanog kandidom (Candida albicans). Procena oralnog zdravlja i smernice za planiranje tipa tretmana. Ovaj članak obezbeđuje korisne smernice za procenu i planiranje tretmana, uzimajući u obzir multi morbiditet, polifarmaciju, demenciju i kapacitet negovatelja. Preventivne mere. Preventivne mere su ključne za dugotrajni uspeh oralnog zdravlja ove populacije i ovde su prikazane smernice za preventivne mere u zavisnosti od stepena funkcionalne zavisnosti. Protetski tretman. Iako su neki stari ljudi sa hendikepom pogodni za konvencionalni protetski tretman, većina ovih pacijenata ima neke kontra indikacije i specifičnosti koje treba uzeti u obzir. Zaključak. Potrebe za oralnim zdravljem starih ljudi sa hendikepom ne smeju biti zanemarene, a uspeh tretmana zavisi od edukacije stomatologa kao i saradnje sa ostalim specijalistima medicinskog tima.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
T2  - Medicinski pregled
T1  - Dental treatment of the elderly people with disabilities
T1  - Stomatološki tretman starih ljudi sa hendikepom
VL  - 71
IS  - 11-12
SP  - 383
EP  - 388
DO  - 10.2298/MPNS1812383P
ER  - 

@article{
author = "Popovac, Aleksandra and Stančić, Ivica and Vuković, Ana and Despotović, Nebojša",
year = "2018",
abstract = "Introduction. The growing population of the elderly people and a proportional increase in the number of the elderly with different types of disabilities, necessitates a multidisciplinary approach to the assessment of their oral health and dental treatment. The ultimate aim is to retain a pain-free functional dentition and decrease the risk of future disease. Material and Methods. A PubMed search was performed and the authors contributed their experience in implementing preventive and therapeutic measures. Oral health problems of the elderly with disabilities. Two main factors influence the oral health: multimorbidity and polypharmacy. Oral health problems expected in this population are teeth abrasion, teeth fractures, root caries, periodontitis and problems with wearing dentures due to stomatitis caused by Candida albicans. Oral health assessment and treatment guidelines. This article provides guidelines for assessment and treatment planning, taking into consideration multimorbidity, polypharmacy, dementia and capacity of caregivers. Preventive measures. Preventive measures are crucial for long-term oral health of this population, and this paper provides guidelines for preventive treatment depending on the degree of functional dependence. Prosthetic treatment. Although some elderly with disabilities are suitable for conventional prosthetic treatment, often there are contraindications and specific considerations that must be taken into account. Conclusion. Oral health needs of the elderly people with disabilities should not be neglected and the success of treatment depends on the education of dental professionals and cooperation with other health professionals of the medical team., Uvod. Zbog rastuće populacije starih ljudi i proporcionalnog povećanja učestalosti broja starih ljudi sa različitim tipovima hendikepa, multi disciplinarni pristup proceni njihovog oralnog zdravlja je neophodan. Krajnji cilj je postići funkcionalnu denticiju bez bolova i smanjiti rizik od budućih oboljenja. Materijal i metode. Pretraživanje literature u bazi PubMed je obavljeno, ali je takođe iskustvo autora u primeni preventivnih i terapijskih mera uzeto u obzir. Problemi oralnog zdravlja starih ljudi sa hendikepom. Dva glavna razloga imaju uticaj na oralno zdravlje: multi morbiditet i polifarmacija. Problemi oralnog zdravlja koji se očekuju u ovoj populaciji su abrazija zuba, frakture zuba, karijes korena, parodontopatija i problemi sa nošenjem proteza usled stomatitis uzrokovanog kandidom (Candida albicans). Procena oralnog zdravlja i smernice za planiranje tipa tretmana. Ovaj članak obezbeđuje korisne smernice za procenu i planiranje tretmana, uzimajući u obzir multi morbiditet, polifarmaciju, demenciju i kapacitet negovatelja. Preventivne mere. Preventivne mere su ključne za dugotrajni uspeh oralnog zdravlja ove populacije i ovde su prikazane smernice za preventivne mere u zavisnosti od stepena funkcionalne zavisnosti. Protetski tretman. Iako su neki stari ljudi sa hendikepom pogodni za konvencionalni protetski tretman, većina ovih pacijenata ima neke kontra indikacije i specifičnosti koje treba uzeti u obzir. Zaključak. Potrebe za oralnim zdravljem starih ljudi sa hendikepom ne smeju biti zanemarene, a uspeh tretmana zavisi od edukacije stomatologa kao i saradnje sa ostalim specijalistima medicinskog tima.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Medicinski pregled",
title = "Dental treatment of the elderly people with disabilities, Stomatološki tretman starih ljudi sa hendikepom",
volume = "71",
number = "11-12",
pages = "383-388",
doi = "10.2298/MPNS1812383P"
}

Popovac, A., Stančić, I., Vuković, A.,& Despotović, N.. (2018). Dental treatment of the elderly people with disabilities. in Medicinski pregled
Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 71(11-12), 383-388.
https://doi.org/10.2298/MPNS1812383P

Popovac A, Stančić I, Vuković A, Despotović N. Dental treatment of the elderly people with disabilities. in Medicinski pregled. 2018;71(11-12):383-388.
doi:10.2298/MPNS1812383P .

Popovac, Aleksandra, Stančić, Ivica, Vuković, Ana, Despotović, Nebojša, "Dental treatment of the elderly people with disabilities" in Medicinski pregled, 71, no. 11-12 (2018):383-388,
https://doi.org/10.2298/MPNS1812383P . .

TY  - JOUR
AU  - Popovac, Aleksandra
AU  - Stančić, Ivica
AU  - Despotović, Nebojša
AU  - Nikolić, Nadja
AU  - Stefanova, Elka
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2116
AB  - Association between dementia and tooth loss has been shown although the nature of that association is not clear. It has also been shown that risk of dementia was increased in apolipoprotein E4 allele carriers. The objective of this study was to determine the frequency of APOE alleles and their association with the dental status in elderly demented patients. Dental status of 67 patients with dementia was recorded. DNA was isolated from buccal swabs and genotyping was done by PCR-RFLP. The majority of participants had E3/E4 genotype (55.2%) and these heterozygotes were significantly more frequent than any other genotype (p lt 0.001). There was no significant association between dental status and genotype. However, partial edentulousness with very few teeth in both jaws (1-9 teeth) was significantly more frequent among demented patients with E3/E4 genotype (p=0.021). Patients with Alzheimer disease most frequently had E3/E4 genotype and had very few or no teeth.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika - Belgrade
T1  - Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease
VL  - 48
IS  - 2
SP  - 699
EP  - 706
DO  - 10.2298/GENSR1602699P
ER  - 

@article{
author = "Popovac, Aleksandra and Stančić, Ivica and Despotović, Nebojša and Nikolić, Nadja and Stefanova, Elka and Milašin, Jelena",
year = "2016",
abstract = "Association between dementia and tooth loss has been shown although the nature of that association is not clear. It has also been shown that risk of dementia was increased in apolipoprotein E4 allele carriers. The objective of this study was to determine the frequency of APOE alleles and their association with the dental status in elderly demented patients. Dental status of 67 patients with dementia was recorded. DNA was isolated from buccal swabs and genotyping was done by PCR-RFLP. The majority of participants had E3/E4 genotype (55.2%) and these heterozygotes were significantly more frequent than any other genotype (p lt 0.001). There was no significant association between dental status and genotype. However, partial edentulousness with very few teeth in both jaws (1-9 teeth) was significantly more frequent among demented patients with E3/E4 genotype (p=0.021). Patients with Alzheimer disease most frequently had E3/E4 genotype and had very few or no teeth.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika - Belgrade",
title = "Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease",
volume = "48",
number = "2",
pages = "699-706",
doi = "10.2298/GENSR1602699P"
}

Popovac, A., Stančić, I., Despotović, N., Nikolić, N., Stefanova, E.,& Milašin, J.. (2016). Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease. in Genetika - Belgrade
Društvo genetičara Srbije, Beograd., 48(2), 699-706.
https://doi.org/10.2298/GENSR1602699P

Popovac A, Stančić I, Despotović N, Nikolić N, Stefanova E, Milašin J. Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease. in Genetika - Belgrade. 2016;48(2):699-706.
doi:10.2298/GENSR1602699P .

Popovac, Aleksandra, Stančić, Ivica, Despotović, Nebojša, Nikolić, Nadja, Stefanova, Elka, Milašin, Jelena, "Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease" in Genetika - Belgrade, 48, no. 2 (2016):699-706,
https://doi.org/10.2298/GENSR1602699P . .

TY  - JOUR
AU  - Stančić, Ivica
AU  - Petrović, Miloš
AU  - Popovac, Aleksandra
AU  - Vasović, Miroslav
AU  - Despotović, Nebojša
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2091
AB  - Background/Aim. Within the elderly population, residents in nursing homes, there is a greather risk of caries, periodontal disease and teeth loss. Assistance of caregivers in maintaininig good oral hygiene besides improving oral health can improve of residents general health and the quality of their lives. The aim of this study was to examine the attitudes of caregivers and knowledge about oral health, as well as the practice regarding oral care they apply at nursing homes in Serbia. Methods. The survey was conducted at the Gerontology Center Belgrade, consisting of four nursing homes located in the urban area. The study included 58 caregivers. They were contacted on working days, in all work shifts, during January, February and March of 2013. They were asked to fill in a self-administered questionnaire consisting of 26 closed-type questions. Results. The care-givers mostly considered that it was very important to take care of oral health of the residents, but 69% responded that the level of their oral health was low or very low. As the main barriers to oral hygiene maintenance, the caregivers indicated lack of time. The caregivers had more knowledge about periodontal disease than about the main cause of caries and its prevention. Formal medical education had the influence on the knowledge about oral diseases. Oral hygiene procedures carried out by the mayority of caregivers were denture cleaning and tooth brushing. Conclusion. The caregivers were aware of the limitations in everyday oral care of nursing homes residents in Serbia, although solving these problems requires the involvement of the entire public health service.
AB  - Uvod/Cilj. U grupi starijih osoba, stanovnika domova za stara lica, postoji povećani rizik od nastanka karijesa, periodontalne bolesti i gubitka zuba. Pomoć u održavanju dobre oralne higijene, pored toga, može uticati i na opšte zdravstveno stanje i kvalitet života stanovnika domova za stara lica. Cilj ovog istraživanja bio je da se ispitaju stavovi i znanje negovatelja o oralnom zdravlju, kao i praksa koju primjenjuju u domovima za stara lica u Srbiji. Metode. Istraživanje je sprovedeno u ustanovi Gerontološki Centar Beograd, koji se sastoji od četiri doma za stara lica, locirana u urbanom području. U istraživanju je učestvovalo 58 negovatelja, s kojima smo kontaktirali radnim danima, u svim radnim smenama, tokom januara, februara i marta 2013. godine. Oni su zamoljeni da samostalno ispune upitnik sastavljen od 26 pitanja zatvorenog tipa. Rezultati. Negovatelji uglavnom smatraju da je veoma važno brinuti se o oralnom zdravlju korisnika domova, ali 69% je odgovorilo da je nivo oralnog zdravlja korisnika nizak ili vrlo nizak. Za glavnu prepreku u održavanju oralne higijene korisnika domova, negovatelji su označili nedostatak vremena. Njegovatelji su imali više znanja o parodontalnim bolestima, nego o glavnom uzročniku karijesa i njegovoj prevenciji. Formalno medicinsko obrazovanje imalo je uticaj na njihovo znanje o oralnim bolestima. Čišćenje proteza i pranje zuba su najčešće primenjivani postupci negovatelja u održavanju oralne higijene korisnika domova. Zaključak. Negovatelji su svesni ograničenja u svakodnevnom održavanju oralnog zdravlja korisnika domova za stara lica u Srbiji, kao i da rešavanje tih problema zahteva uključivanje celokupnog javnog zdravstvenog sektora.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Caregivers' attitudes, knowledge and practices of oral care at nursing homes in Serbia
T1  - Stavovi, znanje i praksa negovatelja u održavanju oralnog zdravlja korisnika domova za stara lica u Srbiji
VL  - 73
IS  - 7
SP  - 668
EP  - 673
DO  - 10.2298/VSP141001065S
ER  - 

@article{
author = "Stančić, Ivica and Petrović, Miloš and Popovac, Aleksandra and Vasović, Miroslav and Despotović, Nebojša",
year = "2016",
abstract = "Background/Aim. Within the elderly population, residents in nursing homes, there is a greather risk of caries, periodontal disease and teeth loss. Assistance of caregivers in maintaininig good oral hygiene besides improving oral health can improve of residents general health and the quality of their lives. The aim of this study was to examine the attitudes of caregivers and knowledge about oral health, as well as the practice regarding oral care they apply at nursing homes in Serbia. Methods. The survey was conducted at the Gerontology Center Belgrade, consisting of four nursing homes located in the urban area. The study included 58 caregivers. They were contacted on working days, in all work shifts, during January, February and March of 2013. They were asked to fill in a self-administered questionnaire consisting of 26 closed-type questions. Results. The care-givers mostly considered that it was very important to take care of oral health of the residents, but 69% responded that the level of their oral health was low or very low. As the main barriers to oral hygiene maintenance, the caregivers indicated lack of time. The caregivers had more knowledge about periodontal disease than about the main cause of caries and its prevention. Formal medical education had the influence on the knowledge about oral diseases. Oral hygiene procedures carried out by the mayority of caregivers were denture cleaning and tooth brushing. Conclusion. The caregivers were aware of the limitations in everyday oral care of nursing homes residents in Serbia, although solving these problems requires the involvement of the entire public health service., Uvod/Cilj. U grupi starijih osoba, stanovnika domova za stara lica, postoji povećani rizik od nastanka karijesa, periodontalne bolesti i gubitka zuba. Pomoć u održavanju dobre oralne higijene, pored toga, može uticati i na opšte zdravstveno stanje i kvalitet života stanovnika domova za stara lica. Cilj ovog istraživanja bio je da se ispitaju stavovi i znanje negovatelja o oralnom zdravlju, kao i praksa koju primjenjuju u domovima za stara lica u Srbiji. Metode. Istraživanje je sprovedeno u ustanovi Gerontološki Centar Beograd, koji se sastoji od četiri doma za stara lica, locirana u urbanom području. U istraživanju je učestvovalo 58 negovatelja, s kojima smo kontaktirali radnim danima, u svim radnim smenama, tokom januara, februara i marta 2013. godine. Oni su zamoljeni da samostalno ispune upitnik sastavljen od 26 pitanja zatvorenog tipa. Rezultati. Negovatelji uglavnom smatraju da je veoma važno brinuti se o oralnom zdravlju korisnika domova, ali 69% je odgovorilo da je nivo oralnog zdravlja korisnika nizak ili vrlo nizak. Za glavnu prepreku u održavanju oralne higijene korisnika domova, negovatelji su označili nedostatak vremena. Njegovatelji su imali više znanja o parodontalnim bolestima, nego o glavnom uzročniku karijesa i njegovoj prevenciji. Formalno medicinsko obrazovanje imalo je uticaj na njihovo znanje o oralnim bolestima. Čišćenje proteza i pranje zuba su najčešće primenjivani postupci negovatelja u održavanju oralne higijene korisnika domova. Zaključak. Negovatelji su svesni ograničenja u svakodnevnom održavanju oralnog zdravlja korisnika domova za stara lica u Srbiji, kao i da rešavanje tih problema zahteva uključivanje celokupnog javnog zdravstvenog sektora.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Caregivers' attitudes, knowledge and practices of oral care at nursing homes in Serbia, Stavovi, znanje i praksa negovatelja u održavanju oralnog zdravlja korisnika domova za stara lica u Srbiji",
volume = "73",
number = "7",
pages = "668-673",
doi = "10.2298/VSP141001065S"
}

Stančić, I., Petrović, M., Popovac, A., Vasović, M.,& Despotović, N.. (2016). Caregivers' attitudes, knowledge and practices of oral care at nursing homes in Serbia. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(7), 668-673.
https://doi.org/10.2298/VSP141001065S

Stančić I, Petrović M, Popovac A, Vasović M, Despotović N. Caregivers' attitudes, knowledge and practices of oral care at nursing homes in Serbia. in Vojnosanitetski pregled. 2016;73(7):668-673.
doi:10.2298/VSP141001065S .

Stančić, Ivica, Petrović, Miloš, Popovac, Aleksandra, Vasović, Miroslav, Despotović, Nebojša, "Caregivers' attitudes, knowledge and practices of oral care at nursing homes in Serbia" in Vojnosanitetski pregled, 73, no. 7 (2016):668-673,
https://doi.org/10.2298/VSP141001065S . .

TY  - JOUR
AU  - Erceg, Predrag
AU  - Despotović, Nebojša
AU  - Milošević, Dragoslav P.
AU  - Soldatović, Ivan
AU  - Zdravković, Sanja
AU  - Tomić, Snezana
AU  - Marković, Ivana
AU  - Mihajlović, Gordana
AU  - Brajović, Milan
AU  - Bojović, Ognjen
AU  - Potić, Bojana
AU  - Davidović, Mladen
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1849
AB  - Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL in elderly heart failure subjects have included mostly outpatients, and little is known about determinants of HRQOL in hospitalized elderly population, especially in Serbia. In this study, we tried to identify factors that influence HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Methods: The study population consisted of 136 patients aged 65 years or older hospitalized for chronic heart failure. HRQOL was assessed using the Minnesota Living with Heart Failure questionnaire. Predictors of HRQOL were identified by multiple linear regression analysis. Results: Univariate analysis showed that patients with lower income, a longer history of chronic heart failure, and longer length of hospital stay, as well as those receiving aldosterone antagonists and digoxin, taking multiple medications, in a higher NYHA class, and showing signs of depression and cognitive impairment had significantly worse HRQOL. Presence of depressive symptoms (P lt 0.001), higher NYHA class (P=0.021), lower income (P=0.029), and longer duration of heart failure (P=0.049) were independent predictors of poor HRQOL. Conclusion: Depressive symptoms, higher NYHA class, lower income, and longer duration of chronic heart failure are independent predictors of poor HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Further, there is an association between multiple medication usage and poor HRQOL, as well as a negative impact of cognitive impairment on HRQOL. Hence, measures should be implemented to identify such patients, especially those with depressive symptoms, and appropriate interventions undertaken in order to improve their HRQOL.
PB  - Dove Medical Press Ltd, Albany
T2  - Clinical Interventions in Aging
T1  - Health-related quality of life in elderly patients hospitalized with chronic heart failure
VL  - 8
SP  - 1539
EP  - 1546
DO  - 10.2147/CIA.S53305
ER  - 

@article{
author = "Erceg, Predrag and Despotović, Nebojša and Milošević, Dragoslav P. and Soldatović, Ivan and Zdravković, Sanja and Tomić, Snezana and Marković, Ivana and Mihajlović, Gordana and Brajović, Milan and Bojović, Ognjen and Potić, Bojana and Davidović, Mladen",
year = "2013",
abstract = "Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL in elderly heart failure subjects have included mostly outpatients, and little is known about determinants of HRQOL in hospitalized elderly population, especially in Serbia. In this study, we tried to identify factors that influence HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Methods: The study population consisted of 136 patients aged 65 years or older hospitalized for chronic heart failure. HRQOL was assessed using the Minnesota Living with Heart Failure questionnaire. Predictors of HRQOL were identified by multiple linear regression analysis. Results: Univariate analysis showed that patients with lower income, a longer history of chronic heart failure, and longer length of hospital stay, as well as those receiving aldosterone antagonists and digoxin, taking multiple medications, in a higher NYHA class, and showing signs of depression and cognitive impairment had significantly worse HRQOL. Presence of depressive symptoms (P lt 0.001), higher NYHA class (P=0.021), lower income (P=0.029), and longer duration of heart failure (P=0.049) were independent predictors of poor HRQOL. Conclusion: Depressive symptoms, higher NYHA class, lower income, and longer duration of chronic heart failure are independent predictors of poor HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Further, there is an association between multiple medication usage and poor HRQOL, as well as a negative impact of cognitive impairment on HRQOL. Hence, measures should be implemented to identify such patients, especially those with depressive symptoms, and appropriate interventions undertaken in order to improve their HRQOL.",
publisher = "Dove Medical Press Ltd, Albany",
journal = "Clinical Interventions in Aging",
title = "Health-related quality of life in elderly patients hospitalized with chronic heart failure",
volume = "8",
pages = "1539-1546",
doi = "10.2147/CIA.S53305"
}

Erceg, P., Despotović, N., Milošević, D. P., Soldatović, I., Zdravković, S., Tomić, S., Marković, I., Mihajlović, G., Brajović, M., Bojović, O., Potić, B.,& Davidović, M.. (2013). Health-related quality of life in elderly patients hospitalized with chronic heart failure. in Clinical Interventions in Aging
Dove Medical Press Ltd, Albany., 8, 1539-1546.
https://doi.org/10.2147/CIA.S53305

Erceg P, Despotović N, Milošević DP, Soldatović I, Zdravković S, Tomić S, Marković I, Mihajlović G, Brajović M, Bojović O, Potić B, Davidović M. Health-related quality of life in elderly patients hospitalized with chronic heart failure. in Clinical Interventions in Aging. 2013;8:1539-1546.
doi:10.2147/CIA.S53305 .

Erceg, Predrag, Despotović, Nebojša, Milošević, Dragoslav P., Soldatović, Ivan, Zdravković, Sanja, Tomić, Snezana, Marković, Ivana, Mihajlović, Gordana, Brajović, Milan, Bojović, Ognjen, Potić, Bojana, Davidović, Mladen, "Health-related quality of life in elderly patients hospitalized with chronic heart failure" in Clinical Interventions in Aging, 8 (2013):1539-1546,
https://doi.org/10.2147/CIA.S53305 . .

TY  - JOUR
AU  - Grubiša, Ivana
AU  - Otašević, Petar
AU  - Despotović, Nebojša
AU  - Dedić, Velimir
AU  - Milašin, Jelena
AU  - Vučinić, Nada
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1807
AB  - One of the characteristics of type 2 diabetes mellitus (T2DM) is the state of persistent oxidative stress (OS) that has been implicated in the pathogenesis of diseases such is atherosclerosis mainly through chronic hyperglycemia that stimulates production of reactive oxygen species (ROS) and increases OS. Glutathione S-transferase P1 (GSTP1) is a member of the cytosolic GST superfamily. It plays an important role in neutralizing OS as an enzyme. Also, it participates in regulation of stress signaling and protects cells against apoptosis via its noncatalytic ligand-binding activity. GSTP1 Ile105Val functional polymorphism influences protein catalytic activity and stability and the aim of this study was to determine whether this gene variation influences susceptibility to atherogenesis in T2DM patients. A total of 240 individuals (140 patients with T2DM, accompanied with clinical manifestations of atherosclerosis, and 100 healthy controls) were included in this study. Genomic DNA was isolated from peripheral blood cells and genotyping was performed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) analysis. We obtained no statistically significant differences in the distribution of alleles and genotypes between cases and controls (P>0.05) but association between Ile/Val (OR=0.6, 95%CI=0.35-1.05, P=0.08) and Val/Val (OR=0.45, 95%CI=0.18-1.11, P=0.08) genotypes and disease approached significance (P=0.08). Our results indicated that a larger study group is needed to establish the true relationship between potentialiy protective allele Val and the disease, and to determine the influence of other GSTP1 polymorphisms on atherogenesis in T2DM patients.
AB  - Jedna od osobina tipa 2 dijabetes mellitus (T2DM) je stanje perzistentnog oksidativnog stresa (OS) koji je sastavni deo patogeneze bolesti kao što je ateroskleroza i to najčešće putem hronične hiperglikemije koja stimuliše nastanak reaktivnih vrsta kiseonika (tzv ROS) i povećava nivo OS. Glutation S-transferaza P1 (GSTP1) pripada superfamiliji citosolnih GST. Kao enzim, ima važnu ulogu u neutralizaciji OS. Takođe, učestvuje u regulaciji signalnog puta stresa ali i štiti ćelije od apoptoze putem nekatalitičke ligand-vezujuće aktivnosti. Funkcionalni polimorfizam Ile105Val GSTP1 gena utiče na katalitičku aktivnost proteina i na njegovu stabilnost i cilj ove studije je bio da se utvrdi da li ova genska varijanta utiče na osetljivost na aterogenezu kod pacijenata sa T2DM. Ukupno 240 osobe (140 pacijenata sa T2DM i nekom od kliničkih manifestacija ateroskleroze i 100 zdravih kontrola) je bilo uključeno u ovu studiju. Genomska DNK je izolovana iz ćelija periferne krvi a genotipizacija je urađena primenom reakcije lančane polimeraze posle koje je urađena analiza dužine restrikcionih fragmenata (PCR-RFLP analiza). Nismo dobili statistički značajne razlike u raspodeli alela i genotipova između obolelih i kontrola (P>0.05) ali asocijacija između Ile/Val (OR=0.6, 95%CI=0.35-1.05, P=0.08) i Val/Val (OR=0.45, 95%CI=0.18-1.11, P=0.08) genotipova i bolesti se približila značajnosti (P=0.08). Naši rezultaati pokazuju da je potrebna veća grupa ispitanika da bi se utvrdila prava veza između potencijalno protektivnog alela Val i bolesti kao i da bi se utvrdio uticaj drugih polimorfizama gena GSTP1 na aterogenezu kod T2DM pacijenata.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika
T1  - Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus
T1  - Genetički polimorfizam glutation S-transferaze P1 (GSTP1) Ile105Val i osetljivost na aterogenezu kod pacijenata sa dijabetesom tipa 2
VL  - 45
IS  - 1
SP  - 227
EP  - 236
DO  - 10.2298/GENSR1301227G
ER  - 

@article{
author = "Grubiša, Ivana and Otašević, Petar and Despotović, Nebojša and Dedić, Velimir and Milašin, Jelena and Vučinić, Nada",
year = "2013",
abstract = "One of the characteristics of type 2 diabetes mellitus (T2DM) is the state of persistent oxidative stress (OS) that has been implicated in the pathogenesis of diseases such is atherosclerosis mainly through chronic hyperglycemia that stimulates production of reactive oxygen species (ROS) and increases OS. Glutathione S-transferase P1 (GSTP1) is a member of the cytosolic GST superfamily. It plays an important role in neutralizing OS as an enzyme. Also, it participates in regulation of stress signaling and protects cells against apoptosis via its noncatalytic ligand-binding activity. GSTP1 Ile105Val functional polymorphism influences protein catalytic activity and stability and the aim of this study was to determine whether this gene variation influences susceptibility to atherogenesis in T2DM patients. A total of 240 individuals (140 patients with T2DM, accompanied with clinical manifestations of atherosclerosis, and 100 healthy controls) were included in this study. Genomic DNA was isolated from peripheral blood cells and genotyping was performed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) analysis. We obtained no statistically significant differences in the distribution of alleles and genotypes between cases and controls (P>0.05) but association between Ile/Val (OR=0.6, 95%CI=0.35-1.05, P=0.08) and Val/Val (OR=0.45, 95%CI=0.18-1.11, P=0.08) genotypes and disease approached significance (P=0.08). Our results indicated that a larger study group is needed to establish the true relationship between potentialiy protective allele Val and the disease, and to determine the influence of other GSTP1 polymorphisms on atherogenesis in T2DM patients., Jedna od osobina tipa 2 dijabetes mellitus (T2DM) je stanje perzistentnog oksidativnog stresa (OS) koji je sastavni deo patogeneze bolesti kao što je ateroskleroza i to najčešće putem hronične hiperglikemije koja stimuliše nastanak reaktivnih vrsta kiseonika (tzv ROS) i povećava nivo OS. Glutation S-transferaza P1 (GSTP1) pripada superfamiliji citosolnih GST. Kao enzim, ima važnu ulogu u neutralizaciji OS. Takođe, učestvuje u regulaciji signalnog puta stresa ali i štiti ćelije od apoptoze putem nekatalitičke ligand-vezujuće aktivnosti. Funkcionalni polimorfizam Ile105Val GSTP1 gena utiče na katalitičku aktivnost proteina i na njegovu stabilnost i cilj ove studije je bio da se utvrdi da li ova genska varijanta utiče na osetljivost na aterogenezu kod pacijenata sa T2DM. Ukupno 240 osobe (140 pacijenata sa T2DM i nekom od kliničkih manifestacija ateroskleroze i 100 zdravih kontrola) je bilo uključeno u ovu studiju. Genomska DNK je izolovana iz ćelija periferne krvi a genotipizacija je urađena primenom reakcije lančane polimeraze posle koje je urađena analiza dužine restrikcionih fragmenata (PCR-RFLP analiza). Nismo dobili statistički značajne razlike u raspodeli alela i genotipova između obolelih i kontrola (P>0.05) ali asocijacija između Ile/Val (OR=0.6, 95%CI=0.35-1.05, P=0.08) i Val/Val (OR=0.45, 95%CI=0.18-1.11, P=0.08) genotipova i bolesti se približila značajnosti (P=0.08). Naši rezultaati pokazuju da je potrebna veća grupa ispitanika da bi se utvrdila prava veza između potencijalno protektivnog alela Val i bolesti kao i da bi se utvrdio uticaj drugih polimorfizama gena GSTP1 na aterogenezu kod T2DM pacijenata.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika",
title = "Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus, Genetički polimorfizam glutation S-transferaze P1 (GSTP1) Ile105Val i osetljivost na aterogenezu kod pacijenata sa dijabetesom tipa 2",
volume = "45",
number = "1",
pages = "227-236",
doi = "10.2298/GENSR1301227G"
}

Grubiša, I., Otašević, P., Despotović, N., Dedić, V., Milašin, J.,& Vučinić, N.. (2013). Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus. in Genetika
Društvo genetičara Srbije, Beograd., 45(1), 227-236.
https://doi.org/10.2298/GENSR1301227G

Grubiša I, Otašević P, Despotović N, Dedić V, Milašin J, Vučinić N. Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus. in Genetika. 2013;45(1):227-236.
doi:10.2298/GENSR1301227G .

Grubiša, Ivana, Otašević, Petar, Despotović, Nebojša, Dedić, Velimir, Milašin, Jelena, Vučinić, Nada, "Genetic polymorphism of glutathion S-transferase P1 (GSTP1) Ile105Val and susceptibility to atherogenesis in patients with type 2 diabetes mellitus" in Genetika, 45, no. 1 (2013):227-236,
https://doi.org/10.2298/GENSR1301227G . .