TY  - JOUR
AU  - Baćević, Miljana
AU  - Brković, Božidar
AU  - Albert, Adelin
AU  - Rompen, Eric
AU  - Radermecker, Regis P.
AU  - Lambert, France
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2213
AB  - Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration.
PB  - Springer, New York
T2  - Calcified Tissue International
T1  - Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review
VL  - 101
IS  - 6
SP  - 553
EP  - 563
DO  - 10.1007/s00223-017-0327-7
ER  - 

@article{
author = "Baćević, Miljana and Brković, Božidar and Albert, Adelin and Rompen, Eric and Radermecker, Regis P. and Lambert, France",
year = "2017",
abstract = "Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration.",
publisher = "Springer, New York",
journal = "Calcified Tissue International",
title = "Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review",
volume = "101",
number = "6",
pages = "553-563",
doi = "10.1007/s00223-017-0327-7"
}

Baćević, M., Brković, B., Albert, A., Rompen, E., Radermecker, R. P.,& Lambert, F.. (2017). Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review. in Calcified Tissue International
Springer, New York., 101(6), 553-563.
https://doi.org/10.1007/s00223-017-0327-7

Baćević M, Brković B, Albert A, Rompen E, Radermecker RP, Lambert F. Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review. in Calcified Tissue International. 2017;101(6):553-563.
doi:10.1007/s00223-017-0327-7 .

Baćević, Miljana, Brković, Božidar, Albert, Adelin, Rompen, Eric, Radermecker, Regis P., Lambert, France, "Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review" in Calcified Tissue International, 101, no. 6 (2017):553-563,
https://doi.org/10.1007/s00223-017-0327-7 . .