TY  - JOUR
AU  - Dragašević, Sanja
AU  - Sokić-Milutinović, Aleksandra
AU  - Stojković-Lalošević, Milica
AU  - Milovanović, Tamara
AU  - Đuranović, Srđan
AU  - Jovanović, Ivan
AU  - Rajić, Sanja
AU  - Stojković, Mirjana
AU  - Miličić, Biljana
AU  - Kmezić, Stefan
AU  - Oluić, Branislav
AU  - Aleksić, Marko
AU  - Pavlović-Marković, Aleksandra
AU  - Popović, Dragan
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2507
AB  - Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.
PB  - Hindawi Ltd, London
T2  - Gastroenterology Research & Practice
T1  - Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients
VL  - 2020
DO  - 10.1155/2020/2065383
ER  - 

@article{
author = "Dragašević, Sanja and Sokić-Milutinović, Aleksandra and Stojković-Lalošević, Milica and Milovanović, Tamara and Đuranović, Srđan and Jovanović, Ivan and Rajić, Sanja and Stojković, Mirjana and Miličić, Biljana and Kmezić, Stefan and Oluić, Branislav and Aleksić, Marko and Pavlović-Marković, Aleksandra and Popović, Dragan",
year = "2020",
abstract = "Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.",
publisher = "Hindawi Ltd, London",
journal = "Gastroenterology Research & Practice",
title = "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients",
volume = "2020",
doi = "10.1155/2020/2065383"
}

Dragašević, S., Sokić-Milutinović, A., Stojković-Lalošević, M., Milovanović, T., Đuranović, S., Jovanović, I., Rajić, S., Stojković, M., Miličić, B., Kmezić, S., Oluić, B., Aleksić, M., Pavlović-Marković, A.,& Popović, D.. (2020). Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice
Hindawi Ltd, London., 2020.
https://doi.org/10.1155/2020/2065383

Dragašević S, Sokić-Milutinović A, Stojković-Lalošević M, Milovanović T, Đuranović S, Jovanović I, Rajić S, Stojković M, Miličić B, Kmezić S, Oluić B, Aleksić M, Pavlović-Marković A, Popović D. Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice. 2020;2020.
doi:10.1155/2020/2065383 .

Dragašević, Sanja, Sokić-Milutinović, Aleksandra, Stojković-Lalošević, Milica, Milovanović, Tamara, Đuranović, Srđan, Jovanović, Ivan, Rajić, Sanja, Stojković, Mirjana, Miličić, Biljana, Kmezić, Stefan, Oluić, Branislav, Aleksić, Marko, Pavlović-Marković, Aleksandra, Popović, Dragan, "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients" in Gastroenterology Research & Practice, 2020 (2020),
https://doi.org/10.1155/2020/2065383 . .

TY  - JOUR
AU  - Milovanović, Tamara
AU  - Copertino, Ana
AU  - Boričić, Ivan
AU  - Miličić, Biljana
AU  - Pavlović-Marković, Aleksandra
AU  - Krstić, Miodrag
AU  - Matović, Vera
AU  - Popović, Dušan Đ.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2294
AB  - In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p  lt  0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures.
AB  - Prethodnih decenija otkrivene su neinvanzivne metode za procenu i praćenje fibroze jetre kod hroničnih bolesti jetre. Cilj ove studije bila je procena dijagnostičke preciznosti neinvanzivnih metoda za određivanje fibroze jetre [tranzijentna elastografija (TE) i biohemijski markeri], pri čemu je kao zlatni standard korišćena biopsija jetre kod bolesnika sa primarnom bilijarnom cirozom. Metode. U studiju su bila uključena 122 bolesnika kod kojih su istog dana urađene biohemijske analize i biopsija jetre, a mesec dana kasnije urađena je TE. Za procenu fibroze jetre korišćen je METAVIR skor, a sve preparate biopsija proverio je jedan patolog. APRI skor - odnos aspartat aminotransferaze (AST) i trombocita, Forns indeks, odnos AST i alanin transaminaze (ALT) i TE poređene su sa stepenom fiboze jetre dobijene na osnovu biopsija jetre u cilju dobijanja najboljeg neinvanzivnog markera u proceni fibroze jetre. Rezultati. Dokazana je statistička značajnost (p  lt  0.05) za APRI skor, Forns indeks i TE za procenu stepena fibroze jetre. TE je imala najbolji dijagnostički učinak u poređenju sa ostalim markerima koje smo istraživali. Optimalne granične vrednosti za TE bile su 4.25 i 5.9 kPa za dijagnozu fibroze jetre i razlikovanje slabe/umerene i uznapredovale fibroze. Površina ispod krive operativnih karakteristka (AUROC) za TE bila je 0.963 i 0.865. Zaključak. Na osnovu rezultata ove studije proizilazili su APRI skor, Forns indeks i TE adekvatni dijagnostički markeri fibroze jetre kod bolesnika sa primarnom biijarnom cirozom, ali je TE najsenzitivniji i najspecifičniji parametar. Koristeći neinvanzivne parametre i metode u svakodnevnoj kliničkoj praksi može se smanjiti, ali ne i potpuno izbaciti, potreba za invanzivnim dijagnostičkim procedurama.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis
T1  - Tranzijentna elastografija u neinvazivnoj proceni fibroze jetre kod bolesnika sa primarnom bilijarnom cirozom
VL  - 75
IS  - 4
SP  - 374
EP  - 379
DO  - 10.2298/VSP160409337A
ER  - 

@article{
author = "Milovanović, Tamara and Copertino, Ana and Boričić, Ivan and Miličić, Biljana and Pavlović-Marković, Aleksandra and Krstić, Miodrag and Matović, Vera and Popović, Dušan Đ.",
year = "2018",
abstract = "In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p  lt  0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures., Prethodnih decenija otkrivene su neinvanzivne metode za procenu i praćenje fibroze jetre kod hroničnih bolesti jetre. Cilj ove studije bila je procena dijagnostičke preciznosti neinvanzivnih metoda za određivanje fibroze jetre [tranzijentna elastografija (TE) i biohemijski markeri], pri čemu je kao zlatni standard korišćena biopsija jetre kod bolesnika sa primarnom bilijarnom cirozom. Metode. U studiju su bila uključena 122 bolesnika kod kojih su istog dana urađene biohemijske analize i biopsija jetre, a mesec dana kasnije urađena je TE. Za procenu fibroze jetre korišćen je METAVIR skor, a sve preparate biopsija proverio je jedan patolog. APRI skor - odnos aspartat aminotransferaze (AST) i trombocita, Forns indeks, odnos AST i alanin transaminaze (ALT) i TE poređene su sa stepenom fiboze jetre dobijene na osnovu biopsija jetre u cilju dobijanja najboljeg neinvanzivnog markera u proceni fibroze jetre. Rezultati. Dokazana je statistička značajnost (p  lt  0.05) za APRI skor, Forns indeks i TE za procenu stepena fibroze jetre. TE je imala najbolji dijagnostički učinak u poređenju sa ostalim markerima koje smo istraživali. Optimalne granične vrednosti za TE bile su 4.25 i 5.9 kPa za dijagnozu fibroze jetre i razlikovanje slabe/umerene i uznapredovale fibroze. Površina ispod krive operativnih karakteristka (AUROC) za TE bila je 0.963 i 0.865. Zaključak. Na osnovu rezultata ove studije proizilazili su APRI skor, Forns indeks i TE adekvatni dijagnostički markeri fibroze jetre kod bolesnika sa primarnom biijarnom cirozom, ali je TE najsenzitivniji i najspecifičniji parametar. Koristeći neinvanzivne parametre i metode u svakodnevnoj kliničkoj praksi može se smanjiti, ali ne i potpuno izbaciti, potreba za invanzivnim dijagnostičkim procedurama.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis, Tranzijentna elastografija u neinvazivnoj proceni fibroze jetre kod bolesnika sa primarnom bilijarnom cirozom",
volume = "75",
number = "4",
pages = "374-379",
doi = "10.2298/VSP160409337A"
}

Milovanović, T., Copertino, A., Boričić, I., Miličić, B., Pavlović-Marković, A., Krstić, M., Matović, V.,& Popović, D. Đ.. (2018). Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(4), 374-379.
https://doi.org/10.2298/VSP160409337A

Milovanović T, Copertino A, Boričić I, Miličić B, Pavlović-Marković A, Krstić M, Matović V, Popović DĐ. Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis. in Vojnosanitetski pregled. 2018;75(4):374-379.
doi:10.2298/VSP160409337A .

Milovanović, Tamara, Copertino, Ana, Boričić, Ivan, Miličić, Biljana, Pavlović-Marković, Aleksandra, Krstić, Miodrag, Matović, Vera, Popović, Dušan Đ., "Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis" in Vojnosanitetski pregled, 75, no. 4 (2018):374-379,
https://doi.org/10.2298/VSP160409337A . .

TY  - JOUR
AU  - Alempijević, Tamara
AU  - Sokić-Milutinović, Aleksandra
AU  - Pavlović-Marković, Aleksandra
AU  - Jesic-Vukicević, Rada
AU  - Miličić, Biljana
AU  - Macut, Đuro
AU  - Popović, Dragan
AU  - Tomić, Dragan
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1740
AB  - Primary biliary cirrhosis (PBC) is a chronic, progressive liver disease with elevated serum lipids. It remains unclear if hyperlipidemia increases the risk for atherosclerosis in PBC patients. Metabolic syndrome (MS) promotes the development of atherosclerotic cardiovascular disease due to abdominal obesity and insulin resistance. The aim of this study was to assess incidence and parameters of MS, as well as subcutaneous and visceral fat using noninvasive ultrasonographic measurement in patients with PBC in our population. We included 55 patients with PBC and 44 age- and sex-matched healthy controls (CG-control group). Anthropometric measurements (weight, height, and waist circumference), age, sex, and body mass index were recorded for patients and controls. Laboratory tests for assessing MS and liver function tests were analyzed. We used ultrasonography to determine subcutaneous and visceral fat diameter and area (SF, VF and SA, VA, respectively), as well as perirenal fat diameter (PF). Patients with PBC had significantly higher levels of cholesterol and liver function tests. There were no statistically significant difference in serum insulin and HOMA levels, as well as incidence of MS was diagnosed in 30.9 % (17/55) PBC patients and 43.2 % (19/44) controls. We registered lower amount of VF (PBC:10.92 +/- 3.63 mm, CG:16.84 +/- 5.51 mm,  lt  0.001), VA (PBC:403.64 +/- 166.97 mm(2), CG:720.57 +/- 272.50 mm(2),  lt  0.001), and PF (PBC:7.03 +/- 1.82 mm, CG 10.49 +/- 2.70 mm,  lt  0.001) in patients with PBC. MS is not more frequent in patients with PBC compared with healthy volunteers in our population. Lower amount of VF could be related to lower risk for cardiovascular events in PBC patients.
PB  - Springer Wien, Wien
T2  - Wiener Klinische Wochenschrift
T1  - Assessment of metabolic syndrome in patients with primary biliary cirrhosis
VL  - 124
IS  - 7-8
SP  - 251
EP  - 255
DO  - 10.1007/s00508-012-0162-9
ER  - 

@article{
author = "Alempijević, Tamara and Sokić-Milutinović, Aleksandra and Pavlović-Marković, Aleksandra and Jesic-Vukicević, Rada and Miličić, Biljana and Macut, Đuro and Popović, Dragan and Tomić, Dragan",
year = "2012",
abstract = "Primary biliary cirrhosis (PBC) is a chronic, progressive liver disease with elevated serum lipids. It remains unclear if hyperlipidemia increases the risk for atherosclerosis in PBC patients. Metabolic syndrome (MS) promotes the development of atherosclerotic cardiovascular disease due to abdominal obesity and insulin resistance. The aim of this study was to assess incidence and parameters of MS, as well as subcutaneous and visceral fat using noninvasive ultrasonographic measurement in patients with PBC in our population. We included 55 patients with PBC and 44 age- and sex-matched healthy controls (CG-control group). Anthropometric measurements (weight, height, and waist circumference), age, sex, and body mass index were recorded for patients and controls. Laboratory tests for assessing MS and liver function tests were analyzed. We used ultrasonography to determine subcutaneous and visceral fat diameter and area (SF, VF and SA, VA, respectively), as well as perirenal fat diameter (PF). Patients with PBC had significantly higher levels of cholesterol and liver function tests. There were no statistically significant difference in serum insulin and HOMA levels, as well as incidence of MS was diagnosed in 30.9 % (17/55) PBC patients and 43.2 % (19/44) controls. We registered lower amount of VF (PBC:10.92 +/- 3.63 mm, CG:16.84 +/- 5.51 mm,  lt  0.001), VA (PBC:403.64 +/- 166.97 mm(2), CG:720.57 +/- 272.50 mm(2),  lt  0.001), and PF (PBC:7.03 +/- 1.82 mm, CG 10.49 +/- 2.70 mm,  lt  0.001) in patients with PBC. MS is not more frequent in patients with PBC compared with healthy volunteers in our population. Lower amount of VF could be related to lower risk for cardiovascular events in PBC patients.",
publisher = "Springer Wien, Wien",
journal = "Wiener Klinische Wochenschrift",
title = "Assessment of metabolic syndrome in patients with primary biliary cirrhosis",
volume = "124",
number = "7-8",
pages = "251-255",
doi = "10.1007/s00508-012-0162-9"
}

Alempijević, T., Sokić-Milutinović, A., Pavlović-Marković, A., Jesic-Vukicević, R., Miličić, B., Macut, Đ., Popović, D.,& Tomić, D.. (2012). Assessment of metabolic syndrome in patients with primary biliary cirrhosis. in Wiener Klinische Wochenschrift
Springer Wien, Wien., 124(7-8), 251-255.
https://doi.org/10.1007/s00508-012-0162-9

Alempijević T, Sokić-Milutinović A, Pavlović-Marković A, Jesic-Vukicević R, Miličić B, Macut Đ, Popović D, Tomić D. Assessment of metabolic syndrome in patients with primary biliary cirrhosis. in Wiener Klinische Wochenschrift. 2012;124(7-8):251-255.
doi:10.1007/s00508-012-0162-9 .

Alempijević, Tamara, Sokić-Milutinović, Aleksandra, Pavlović-Marković, Aleksandra, Jesic-Vukicević, Rada, Miličić, Biljana, Macut, Đuro, Popović, Dragan, Tomić, Dragan, "Assessment of metabolic syndrome in patients with primary biliary cirrhosis" in Wiener Klinische Wochenschrift, 124, no. 7-8 (2012):251-255,
https://doi.org/10.1007/s00508-012-0162-9 . .