TY  - JOUR
AU  - Dragašević, Sanja
AU  - Sokić-Milutinović, Aleksandra
AU  - Stojković-Lalošević, Milica
AU  - Milovanović, Tamara
AU  - Đuranović, Srđan
AU  - Jovanović, Ivan
AU  - Rajić, Sanja
AU  - Stojković, Mirjana
AU  - Miličić, Biljana
AU  - Kmezić, Stefan
AU  - Oluić, Branislav
AU  - Aleksić, Marko
AU  - Pavlović-Marković, Aleksandra
AU  - Popović, Dragan
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2507
AB  - Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.
PB  - Hindawi Ltd, London
T2  - Gastroenterology Research & Practice
T1  - Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients
VL  - 2020
DO  - 10.1155/2020/2065383
ER  - 

@article{
author = "Dragašević, Sanja and Sokić-Milutinović, Aleksandra and Stojković-Lalošević, Milica and Milovanović, Tamara and Đuranović, Srđan and Jovanović, Ivan and Rajić, Sanja and Stojković, Mirjana and Miličić, Biljana and Kmezić, Stefan and Oluić, Branislav and Aleksić, Marko and Pavlović-Marković, Aleksandra and Popović, Dragan",
year = "2020",
abstract = "Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.",
publisher = "Hindawi Ltd, London",
journal = "Gastroenterology Research & Practice",
title = "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients",
volume = "2020",
doi = "10.1155/2020/2065383"
}

Dragašević, S., Sokić-Milutinović, A., Stojković-Lalošević, M., Milovanović, T., Đuranović, S., Jovanović, I., Rajić, S., Stojković, M., Miličić, B., Kmezić, S., Oluić, B., Aleksić, M., Pavlović-Marković, A.,& Popović, D.. (2020). Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice
Hindawi Ltd, London., 2020.
https://doi.org/10.1155/2020/2065383

Dragašević S, Sokić-Milutinović A, Stojković-Lalošević M, Milovanović T, Đuranović S, Jovanović I, Rajić S, Stojković M, Miličić B, Kmezić S, Oluić B, Aleksić M, Pavlović-Marković A, Popović D. Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice. 2020;2020.
doi:10.1155/2020/2065383 .

Dragašević, Sanja, Sokić-Milutinović, Aleksandra, Stojković-Lalošević, Milica, Milovanović, Tamara, Đuranović, Srđan, Jovanović, Ivan, Rajić, Sanja, Stojković, Mirjana, Miličić, Biljana, Kmezić, Stefan, Oluić, Branislav, Aleksić, Marko, Pavlović-Marković, Aleksandra, Popović, Dragan, "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients" in Gastroenterology Research & Practice, 2020 (2020),
https://doi.org/10.1155/2020/2065383 . .

TY  - JOUR
AU  - Milovanović, Tamara
AU  - Dragašević, Sanja
AU  - Stojković-Lalošević, Milica
AU  - Zgradić, Sanja
AU  - Miličić, Biljana
AU  - Dumić, Igor
AU  - Kmezić, Stefan
AU  - Saponjski, Dušan
AU  - Antić, Andrija
AU  - Marković, Velimir
AU  - Popović, Dragan
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2416
AB  - Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non-alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD.
PB  - Mdpi, Basel
T2  - Medicina-Lithuania
T1  - Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study
VL  - 55
IS  - 10
DO  - 10.3390/medicina55100697
ER  - 

@article{
author = "Milovanović, Tamara and Dragašević, Sanja and Stojković-Lalošević, Milica and Zgradić, Sanja and Miličić, Biljana and Dumić, Igor and Kmezić, Stefan and Saponjski, Dušan and Antić, Andrija and Marković, Velimir and Popović, Dragan",
year = "2019",
abstract = "Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non-alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD.",
publisher = "Mdpi, Basel",
journal = "Medicina-Lithuania",
title = "Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study",
volume = "55",
number = "10",
doi = "10.3390/medicina55100697"
}

Milovanović, T., Dragašević, S., Stojković-Lalošević, M., Zgradić, S., Miličić, B., Dumić, I., Kmezić, S., Saponjski, D., Antić, A., Marković, V.,& Popović, D.. (2019). Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study. in Medicina-Lithuania
Mdpi, Basel., 55(10).
https://doi.org/10.3390/medicina55100697

Milovanović T, Dragašević S, Stojković-Lalošević M, Zgradić S, Miličić B, Dumić I, Kmezić S, Saponjski D, Antić A, Marković V, Popović D. Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study. in Medicina-Lithuania. 2019;55(10).
doi:10.3390/medicina55100697 .

Milovanović, Tamara, Dragašević, Sanja, Stojković-Lalošević, Milica, Zgradić, Sanja, Miličić, Biljana, Dumić, Igor, Kmezić, Stefan, Saponjski, Dušan, Antić, Andrija, Marković, Velimir, Popović, Dragan, "Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study" in Medicina-Lithuania, 55, no. 10 (2019),
https://doi.org/10.3390/medicina55100697 . .

TY  - JOUR
AU  - Stanković-Popović, Verica
AU  - Popović, Dragan
AU  - Dimković, Nada
AU  - Maksić, Đoko
AU  - Vasilijić, Saša
AU  - Čolić, Miodrag
AU  - Vučinić, Žarko
AU  - Rađen, Slavica
AU  - Miličić, Biljana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1774
AB  - Background/Aim. Morbidity and mortality of continous ambulatory peritoneal dialysis (CAPD) patients is still very high. The aim of the study was to evaluate the effects of peritoneal dialysis (PD) solutions (standard vs biocompatible) on long-term patients' and the techique survival. Methods. A total of 42 stable patients on CAPD participated in this crosssectional study. They were prospectively followed-up during the twelve years. Patients with severe anemia (Hb  lt  10 g/L) and malignant disease ware excluded. Twenty one (50%) patients were treated with the standard PD solutions (CAPDP- 1) while the other 21 (50%) were treated with biocompatible PD solutions [(lower level of glucose degradation products, lower concentration of Ca2+ and neutral pH (CAPDP-2)]. All patients were analyzed for a presence of vascular calcification, nutrition status, and parameters of inflammation after 2.5 ± 0.6 years of starting CAPD, and these variables considered in the analysis as risk factors. Results. The patients from the group CAPDP-2 compared to those from the group CAPDP-1 had lower level of high-sensitivity C-reactive protein (hs-CRP) (p = 0.003), and better nutritional status as confirmed by the mid-arm circumference (p = 0.015), and midarm muscle circumference (p = 0.002) and subjective global assessment (p = 0.000). Also, they had lower vascular calcifications as confirmed by intima media thickness (IMT) (p = 0.003), degree of carotid narrowing (p = 0.001) and calcified plaques of common carotid arteries (CCA) (p = 0.008). Kaplan- Meier analysis confirmed better survival of patients from the group CAPDP-2 than those from the group CAPDP-1 (1-, 5-, and 10-year patients survival rate was: 100%, 61.9% and 14.3% for the group CAPDP-1, and 100%, 85.7%, and 52.4% for the group CAPDP-2, respectively; p = 0.0345). The 1-, 5-, and 10-year technique survival rate was: 100%, 71.4%, and 38.1% for the group CAPDP-1, and 100%, 85.7%, and 76.2% for the group CAPDP-2, respectively; (p = 0.0719). Duration of dialysis, serum triglyceride and cardiovascular score (quantitative scoring system consisting of: ejection fraction (EF) of left ventricle  lt  50%; IMT > 1 mm; carotid narrowing degree > 50%, presence of carotid plaques in both common carotide, ischaemic heart disease, cerebrovascular event and peripheral vascular disease with or without amputation) were independent predictors of overall patient survival. Duration of dialysis was only independent predictor of overall technique survival. Conclusion. Although patients treated with biocompatible solutions showed significantly better survival, the role of biocompatibility of CAPD solutions in patients and technique survival have to be confirmed. Namely, multivariate analysis confirmed that duration of dialysis, serum triglyceride and cardiovascular score significantly predicted overall CAPD patients survival, while only duration of dialysis was found to be independent predictor of overall technique survival.
AB  - Uvod/Cilj. Morbiditet i mortalitet bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi (KAPD) i dalje je neprihvatljivo visok. Cilj rada bio je da se proceni uticaj vrste dijaliznih rasvora (bioinkompatibilni vs biokompatibilni) na višegodišnje preživljavanje bolesnika i same tehnike KAPD. Metode. Ovom studijom preseka sa delimično prospektivnim praćenjem ishoda lečenja obuhvaćeno je ukupno 42 nasumice izabrana, stabilna bolesnika (26 muškaraca i 16 žena) lečena primenom metode KAPD tokom poslednjih 12 godina. Isključeni su bolesnici sa teškom anemijom (Hb  lt 10 g/L) i malignom bolešću. Pri tome, 21 (50%) bolesnika kontinuirano je lečeno bioinkompatibilnim rastvorom za KAPD (kiseli standardni rastvor - ANDY-disc; grupa KAPDB-1), dok je preostalih 21 bolesnik sve vreme bilo na biokompatibilnijem rastvoru za KAPD (neutralni rastvor sa znatno manjom koncentracijom degradacionih produkata glukoze, 1.25 mmol/L Ca i 40 mmol/L laktata - Gambrosol Trio; grupa KAPDB-2). Svim bolesnicima određeni su odabrani parametri hronične inflamacije, malnutricije i ateroskleroze zajedno sa transportnim karakteristikama peritoneumske membrane i rezidualnom bubrežnom funkcijom nakon 2,5 ± 0,6 god od započinjanja KAPD. Svi dobijeni rezultati analizirani su kao potencijalni faktori rizika. Rezultati. Grupa KAPDB-2 u odnosu na KAPDB-1 imala je statistički značajno niže vrednosti serumskog hs-CRP (p = 0,003) i bolje parametre nutritivnog statusa izražene kroz obim nadlaktice (p = 0,015), obim mišića nadlaktice (p = 0,002) i subjektivnu globalnu procenu (p = 0,000) kao i u manjoj meri prisutnu aterosklerozu potvrđeno debljinom intimomedijalnog kompleksa (IMT) (p = 0,003), stepenom suženja karotida (p = 0,001) i prisustvom kalcifikovanih ateromatoznih plakova na karotidnim arterijama (p = 0,008). Kaplan-Meier-ova kriva preživljavanja potvrdila je značajno duže preživljavanje bolesnika u grupi KAPD-2 u odnosu na KAPDB-1 (1-, 5-, i 10-godišnje preživljavanje bolesnika iznosilo je redom: 100%, 61.9% i 14.3% u KAPDB-1, a 100%, 85,7% i 52,4% u KAPDB-2 grupi; p = 0,0345). Stopa 1-, 5-, i 10-godišnjeg preživljavanja metode iznosila je: 100%, 71,4% i 38,1% u KAPDB-1, a 100%, 85,7% i 76,2% u KAPDB-2 grupi (p = 0,0719). Kao nezavisni prediktori opšteg preživljavanja bolesnika na KAPD izdvojili su se: dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta (kvantitativni sistem zbrajanja prisutnih sledećih parametara: ejekciona frakcija (EF) leve komore  lt  50%; IMT >1 mm; suženje lumena karotida > 50%; kalcifikovani ateromatozni plakovi na obe karotide; ishemijska bolest srca; cerebrovaskularni događaj i periferna vaskularna bolest sa ili bez gangrene). Kao nezavisan prediktor preživljavanja metode izdvojio se jedino dijalizni staž. Zaključak. Iako su bolesnici na KAPD sa biokompatibilnijim rastvorima pokazali statistički značajno bolje preživljavanje, ne možemo tvrditi da bioinkompatibilnost dijaliznih rastvora predstavlja značajan faktor rizika od preživljavanja bolesnika i same metode lečenja. Naime, multivarijantnom analizom kao prediktori opšteg preživljavanja bolesnika izdvojili su se samo dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta, dok se za očuvanje peritoneumske membrane kao nezavisan faktor rizika prikazao samo dijalizni staž.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself
T1  - Uticaj biokompatibilnosti rastvora za peritoneumsku dijalizu na višegodišnje preživljavanje bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi i same metode lečenja
VL  - 70
IS  - 4
SP  - 352
EP  - 362
DO  - 10.2298/VSP1304352S
ER  - 

@article{
author = "Stanković-Popović, Verica and Popović, Dragan and Dimković, Nada and Maksić, Đoko and Vasilijić, Saša and Čolić, Miodrag and Vučinić, Žarko and Rađen, Slavica and Miličić, Biljana",
year = "2013",
abstract = "Background/Aim. Morbidity and mortality of continous ambulatory peritoneal dialysis (CAPD) patients is still very high. The aim of the study was to evaluate the effects of peritoneal dialysis (PD) solutions (standard vs biocompatible) on long-term patients' and the techique survival. Methods. A total of 42 stable patients on CAPD participated in this crosssectional study. They were prospectively followed-up during the twelve years. Patients with severe anemia (Hb  lt  10 g/L) and malignant disease ware excluded. Twenty one (50%) patients were treated with the standard PD solutions (CAPDP- 1) while the other 21 (50%) were treated with biocompatible PD solutions [(lower level of glucose degradation products, lower concentration of Ca2+ and neutral pH (CAPDP-2)]. All patients were analyzed for a presence of vascular calcification, nutrition status, and parameters of inflammation after 2.5 ± 0.6 years of starting CAPD, and these variables considered in the analysis as risk factors. Results. The patients from the group CAPDP-2 compared to those from the group CAPDP-1 had lower level of high-sensitivity C-reactive protein (hs-CRP) (p = 0.003), and better nutritional status as confirmed by the mid-arm circumference (p = 0.015), and midarm muscle circumference (p = 0.002) and subjective global assessment (p = 0.000). Also, they had lower vascular calcifications as confirmed by intima media thickness (IMT) (p = 0.003), degree of carotid narrowing (p = 0.001) and calcified plaques of common carotid arteries (CCA) (p = 0.008). Kaplan- Meier analysis confirmed better survival of patients from the group CAPDP-2 than those from the group CAPDP-1 (1-, 5-, and 10-year patients survival rate was: 100%, 61.9% and 14.3% for the group CAPDP-1, and 100%, 85.7%, and 52.4% for the group CAPDP-2, respectively; p = 0.0345). The 1-, 5-, and 10-year technique survival rate was: 100%, 71.4%, and 38.1% for the group CAPDP-1, and 100%, 85.7%, and 76.2% for the group CAPDP-2, respectively; (p = 0.0719). Duration of dialysis, serum triglyceride and cardiovascular score (quantitative scoring system consisting of: ejection fraction (EF) of left ventricle  lt  50%; IMT > 1 mm; carotid narrowing degree > 50%, presence of carotid plaques in both common carotide, ischaemic heart disease, cerebrovascular event and peripheral vascular disease with or without amputation) were independent predictors of overall patient survival. Duration of dialysis was only independent predictor of overall technique survival. Conclusion. Although patients treated with biocompatible solutions showed significantly better survival, the role of biocompatibility of CAPD solutions in patients and technique survival have to be confirmed. Namely, multivariate analysis confirmed that duration of dialysis, serum triglyceride and cardiovascular score significantly predicted overall CAPD patients survival, while only duration of dialysis was found to be independent predictor of overall technique survival., Uvod/Cilj. Morbiditet i mortalitet bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi (KAPD) i dalje je neprihvatljivo visok. Cilj rada bio je da se proceni uticaj vrste dijaliznih rasvora (bioinkompatibilni vs biokompatibilni) na višegodišnje preživljavanje bolesnika i same tehnike KAPD. Metode. Ovom studijom preseka sa delimično prospektivnim praćenjem ishoda lečenja obuhvaćeno je ukupno 42 nasumice izabrana, stabilna bolesnika (26 muškaraca i 16 žena) lečena primenom metode KAPD tokom poslednjih 12 godina. Isključeni su bolesnici sa teškom anemijom (Hb  lt 10 g/L) i malignom bolešću. Pri tome, 21 (50%) bolesnika kontinuirano je lečeno bioinkompatibilnim rastvorom za KAPD (kiseli standardni rastvor - ANDY-disc; grupa KAPDB-1), dok je preostalih 21 bolesnik sve vreme bilo na biokompatibilnijem rastvoru za KAPD (neutralni rastvor sa znatno manjom koncentracijom degradacionih produkata glukoze, 1.25 mmol/L Ca i 40 mmol/L laktata - Gambrosol Trio; grupa KAPDB-2). Svim bolesnicima određeni su odabrani parametri hronične inflamacije, malnutricije i ateroskleroze zajedno sa transportnim karakteristikama peritoneumske membrane i rezidualnom bubrežnom funkcijom nakon 2,5 ± 0,6 god od započinjanja KAPD. Svi dobijeni rezultati analizirani su kao potencijalni faktori rizika. Rezultati. Grupa KAPDB-2 u odnosu na KAPDB-1 imala je statistički značajno niže vrednosti serumskog hs-CRP (p = 0,003) i bolje parametre nutritivnog statusa izražene kroz obim nadlaktice (p = 0,015), obim mišića nadlaktice (p = 0,002) i subjektivnu globalnu procenu (p = 0,000) kao i u manjoj meri prisutnu aterosklerozu potvrđeno debljinom intimomedijalnog kompleksa (IMT) (p = 0,003), stepenom suženja karotida (p = 0,001) i prisustvom kalcifikovanih ateromatoznih plakova na karotidnim arterijama (p = 0,008). Kaplan-Meier-ova kriva preživljavanja potvrdila je značajno duže preživljavanje bolesnika u grupi KAPD-2 u odnosu na KAPDB-1 (1-, 5-, i 10-godišnje preživljavanje bolesnika iznosilo je redom: 100%, 61.9% i 14.3% u KAPDB-1, a 100%, 85,7% i 52,4% u KAPDB-2 grupi; p = 0,0345). Stopa 1-, 5-, i 10-godišnjeg preživljavanja metode iznosila je: 100%, 71,4% i 38,1% u KAPDB-1, a 100%, 85,7% i 76,2% u KAPDB-2 grupi (p = 0,0719). Kao nezavisni prediktori opšteg preživljavanja bolesnika na KAPD izdvojili su se: dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta (kvantitativni sistem zbrajanja prisutnih sledećih parametara: ejekciona frakcija (EF) leve komore  lt  50%; IMT >1 mm; suženje lumena karotida > 50%; kalcifikovani ateromatozni plakovi na obe karotide; ishemijska bolest srca; cerebrovaskularni događaj i periferna vaskularna bolest sa ili bez gangrene). Kao nezavisan prediktor preživljavanja metode izdvojio se jedino dijalizni staž. Zaključak. Iako su bolesnici na KAPD sa biokompatibilnijim rastvorima pokazali statistički značajno bolje preživljavanje, ne možemo tvrditi da bioinkompatibilnost dijaliznih rastvora predstavlja značajan faktor rizika od preživljavanja bolesnika i same metode lečenja. Naime, multivarijantnom analizom kao prediktori opšteg preživljavanja bolesnika izdvojili su se samo dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta, dok se za očuvanje peritoneumske membrane kao nezavisan faktor rizika prikazao samo dijalizni staž.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself, Uticaj biokompatibilnosti rastvora za peritoneumsku dijalizu na višegodišnje preživljavanje bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi i same metode lečenja",
volume = "70",
number = "4",
pages = "352-362",
doi = "10.2298/VSP1304352S"
}

Stanković-Popović, V., Popović, D., Dimković, N., Maksić, Đ., Vasilijić, S., Čolić, M., Vučinić, Ž., Rađen, S.,& Miličić, B.. (2013). Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 352-362.
https://doi.org/10.2298/VSP1304352S

Stanković-Popović V, Popović D, Dimković N, Maksić Đ, Vasilijić S, Čolić M, Vučinić Ž, Rađen S, Miličić B. Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself. in Vojnosanitetski pregled. 2013;70(4):352-362.
doi:10.2298/VSP1304352S .

Stanković-Popović, Verica, Popović, Dragan, Dimković, Nada, Maksić, Đoko, Vasilijić, Saša, Čolić, Miodrag, Vučinić, Žarko, Rađen, Slavica, Miličić, Biljana, "Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself" in Vojnosanitetski pregled, 70, no. 4 (2013):352-362,
https://doi.org/10.2298/VSP1304352S . .

TY  - JOUR
AU  - Alempijević, Tamara
AU  - Sokić-Milutinović, Aleksandra
AU  - Pavlović-Marković, Aleksandra
AU  - Jesic-Vukicević, Rada
AU  - Miličić, Biljana
AU  - Macut, Đuro
AU  - Popović, Dragan
AU  - Tomić, Dragan
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1740
AB  - Primary biliary cirrhosis (PBC) is a chronic, progressive liver disease with elevated serum lipids. It remains unclear if hyperlipidemia increases the risk for atherosclerosis in PBC patients. Metabolic syndrome (MS) promotes the development of atherosclerotic cardiovascular disease due to abdominal obesity and insulin resistance. The aim of this study was to assess incidence and parameters of MS, as well as subcutaneous and visceral fat using noninvasive ultrasonographic measurement in patients with PBC in our population. We included 55 patients with PBC and 44 age- and sex-matched healthy controls (CG-control group). Anthropometric measurements (weight, height, and waist circumference), age, sex, and body mass index were recorded for patients and controls. Laboratory tests for assessing MS and liver function tests were analyzed. We used ultrasonography to determine subcutaneous and visceral fat diameter and area (SF, VF and SA, VA, respectively), as well as perirenal fat diameter (PF). Patients with PBC had significantly higher levels of cholesterol and liver function tests. There were no statistically significant difference in serum insulin and HOMA levels, as well as incidence of MS was diagnosed in 30.9 % (17/55) PBC patients and 43.2 % (19/44) controls. We registered lower amount of VF (PBC:10.92 +/- 3.63 mm, CG:16.84 +/- 5.51 mm,  lt  0.001), VA (PBC:403.64 +/- 166.97 mm(2), CG:720.57 +/- 272.50 mm(2),  lt  0.001), and PF (PBC:7.03 +/- 1.82 mm, CG 10.49 +/- 2.70 mm,  lt  0.001) in patients with PBC. MS is not more frequent in patients with PBC compared with healthy volunteers in our population. Lower amount of VF could be related to lower risk for cardiovascular events in PBC patients.
PB  - Springer Wien, Wien
T2  - Wiener Klinische Wochenschrift
T1  - Assessment of metabolic syndrome in patients with primary biliary cirrhosis
VL  - 124
IS  - 7-8
SP  - 251
EP  - 255
DO  - 10.1007/s00508-012-0162-9
ER  - 

@article{
author = "Alempijević, Tamara and Sokić-Milutinović, Aleksandra and Pavlović-Marković, Aleksandra and Jesic-Vukicević, Rada and Miličić, Biljana and Macut, Đuro and Popović, Dragan and Tomić, Dragan",
year = "2012",
abstract = "Primary biliary cirrhosis (PBC) is a chronic, progressive liver disease with elevated serum lipids. It remains unclear if hyperlipidemia increases the risk for atherosclerosis in PBC patients. Metabolic syndrome (MS) promotes the development of atherosclerotic cardiovascular disease due to abdominal obesity and insulin resistance. The aim of this study was to assess incidence and parameters of MS, as well as subcutaneous and visceral fat using noninvasive ultrasonographic measurement in patients with PBC in our population. We included 55 patients with PBC and 44 age- and sex-matched healthy controls (CG-control group). Anthropometric measurements (weight, height, and waist circumference), age, sex, and body mass index were recorded for patients and controls. Laboratory tests for assessing MS and liver function tests were analyzed. We used ultrasonography to determine subcutaneous and visceral fat diameter and area (SF, VF and SA, VA, respectively), as well as perirenal fat diameter (PF). Patients with PBC had significantly higher levels of cholesterol and liver function tests. There were no statistically significant difference in serum insulin and HOMA levels, as well as incidence of MS was diagnosed in 30.9 % (17/55) PBC patients and 43.2 % (19/44) controls. We registered lower amount of VF (PBC:10.92 +/- 3.63 mm, CG:16.84 +/- 5.51 mm,  lt  0.001), VA (PBC:403.64 +/- 166.97 mm(2), CG:720.57 +/- 272.50 mm(2),  lt  0.001), and PF (PBC:7.03 +/- 1.82 mm, CG 10.49 +/- 2.70 mm,  lt  0.001) in patients with PBC. MS is not more frequent in patients with PBC compared with healthy volunteers in our population. Lower amount of VF could be related to lower risk for cardiovascular events in PBC patients.",
publisher = "Springer Wien, Wien",
journal = "Wiener Klinische Wochenschrift",
title = "Assessment of metabolic syndrome in patients with primary biliary cirrhosis",
volume = "124",
number = "7-8",
pages = "251-255",
doi = "10.1007/s00508-012-0162-9"
}

Alempijević, T., Sokić-Milutinović, A., Pavlović-Marković, A., Jesic-Vukicević, R., Miličić, B., Macut, Đ., Popović, D.,& Tomić, D.. (2012). Assessment of metabolic syndrome in patients with primary biliary cirrhosis. in Wiener Klinische Wochenschrift
Springer Wien, Wien., 124(7-8), 251-255.
https://doi.org/10.1007/s00508-012-0162-9

Alempijević T, Sokić-Milutinović A, Pavlović-Marković A, Jesic-Vukicević R, Miličić B, Macut Đ, Popović D, Tomić D. Assessment of metabolic syndrome in patients with primary biliary cirrhosis. in Wiener Klinische Wochenschrift. 2012;124(7-8):251-255.
doi:10.1007/s00508-012-0162-9 .

Alempijević, Tamara, Sokić-Milutinović, Aleksandra, Pavlović-Marković, Aleksandra, Jesic-Vukicević, Rada, Miličić, Biljana, Macut, Đuro, Popović, Dragan, Tomić, Dragan, "Assessment of metabolic syndrome in patients with primary biliary cirrhosis" in Wiener Klinische Wochenschrift, 124, no. 7-8 (2012):251-255,
https://doi.org/10.1007/s00508-012-0162-9 . .

TY  - JOUR
AU  - Alempijević, Tamara
AU  - Sokić-Milutinović, Aleksandra
AU  - Miličić, Biljana
AU  - Jesić, Rada
AU  - Balović, Ana
AU  - Popović, Dragan
AU  - Krstić, Miodrag
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1712
AB  - Background/aims: Portal hypertension and development of esophageal varices is one of the major complications of liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic liver cirrhosis. Material and Methods: We included in our study 86 patients (74 males, mean age 55 +/- 7) with alcoholic liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical work up, upper digestive endoscopy and ultrasonography examination. The right liver lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with liver cirrhosis was also determined. Results: The mean value of right liver lobe diameter-albumin ratio was 6.15 +/- 1.77, and statistically significantly differed from values determined in the control group (4.97 +/- 1.68). The mean platelet count-spleen diameter ratio was 972.5 +/- 599.0 in alcoholic liver cirrhosis and 1055.9 +/- 821.3 in controls (p>0.05). In patients with alcoholic liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices. Conclusions: Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.
PB  - Turkish Soc Gastroenterology, Abidinpasa
T2  - Turkish Journal of Gastroenterology
T1  - Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis
VL  - 23
IS  - 3
SP  - 239
EP  - 246
DO  - 10.4318/tjg.2012.0463
ER  - 

@article{
author = "Alempijević, Tamara and Sokić-Milutinović, Aleksandra and Miličić, Biljana and Jesić, Rada and Balović, Ana and Popović, Dragan and Krstić, Miodrag",
year = "2012",
abstract = "Background/aims: Portal hypertension and development of esophageal varices is one of the major complications of liver cirrhosis. The aim of our study was to evaluate the possibility of the presence of esophageal varices and their size using biochemical and ultrasonography parameters in patients with alcoholic liver cirrhosis. Material and Methods: We included in our study 86 patients (74 males, mean age 55 +/- 7) with alcoholic liver cirrhosis. The control group consisted of 102 patients with cirrhosis of other etiologies. All patients underwent a complete biochemical work up, upper digestive endoscopy and ultrasonography examination. The right liver lobe diameter/albumin and platelet count/spleen diameter ratios were calculated. The correlation of the calculated ratios with the presence and degree of esophageal varices in patients with liver cirrhosis was also determined. Results: The mean value of right liver lobe diameter-albumin ratio was 6.15 +/- 1.77, and statistically significantly differed from values determined in the control group (4.97 +/- 1.68). The mean platelet count-spleen diameter ratio was 972.5 +/- 599.0 in alcoholic liver cirrhosis and 1055.9 +/- 821.3 in controls (p>0.05). In patients with alcoholic liver cirrhosis, none of the analyzed noninvasive markers was shown to be a good predictor of the presence and size of esophageal varices. Conclusions: Despite the important role of noninvasive markers in providing information pertinent to determination of esophageal varices in patients with liver cirrhosis, these markers have limited relevance in patients with alcoholic cirrhosis.",
publisher = "Turkish Soc Gastroenterology, Abidinpasa",
journal = "Turkish Journal of Gastroenterology",
title = "Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis",
volume = "23",
number = "3",
pages = "239-246",
doi = "10.4318/tjg.2012.0463"
}

Alempijević, T., Sokić-Milutinović, A., Miličić, B., Jesić, R., Balović, A., Popović, D.,& Krstić, M.. (2012). Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis. in Turkish Journal of Gastroenterology
Turkish Soc Gastroenterology, Abidinpasa., 23(3), 239-246.
https://doi.org/10.4318/tjg.2012.0463

Alempijević T, Sokić-Milutinović A, Miličić B, Jesić R, Balović A, Popović D, Krstić M. Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis. in Turkish Journal of Gastroenterology. 2012;23(3):239-246.
doi:10.4318/tjg.2012.0463 .

Alempijević, Tamara, Sokić-Milutinović, Aleksandra, Miličić, Biljana, Jesić, Rada, Balović, Ana, Popović, Dragan, Krstić, Miodrag, "Noninvasive assessment of portal hypertension in patients with alcoholic cirrhosis" in Turkish Journal of Gastroenterology, 23, no. 3 (2012):239-246,
https://doi.org/10.4318/tjg.2012.0463 . .

TY  - JOUR
AU  - Lukić, Snezana
AU  - Nikolić, Aleksandra
AU  - Alempijević, Tamara
AU  - Popović, Dragan
AU  - Sokić-Milutinović, Aleksandra
AU  - Ugljesić, Milenko
AU  - Knežević, Srbislav
AU  - Miličić, Biljana
AU  - Dinić, Dragica
AU  - Radojković, Dragica
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1613
AB  - The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.
PB  - Karger, Basel
T2  - Digestive Surgery
T1  - Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer
VL  - 28
IS  - 4
SP  - 258
EP  - 262
DO  - 10.1159/000328666
ER  - 

@article{
author = "Lukić, Snezana and Nikolić, Aleksandra and Alempijević, Tamara and Popović, Dragan and Sokić-Milutinović, Aleksandra and Ugljesić, Milenko and Knežević, Srbislav and Miličić, Biljana and Dinić, Dragica and Radojković, Dragica",
year = "2011",
abstract = "The purpose of this study was to determine the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and to investigate its role as a potential risk factor in patients with chronic pancreatitis and pancreatic cancer. Deletion polymorphism of the 287-bp fragment of intron 16 of the ACE gene results in higher levels of circulating enzyme and therefore may represent a risk factor for disease development. The study included 55 patients with chronic pancreatitis, 45 patients with pancreatic cancer and 128 healthy subjects. The presence of I and D variants in the ACE gene was analyzed by a polymerase chain reaction (PCR) method. Distribution of ACE ID genotypes was analyzed by means of logistic regression. When chronic pancreatitis and pancreatic cancer groups were compared in the univariate analysis, the following factors were identified as statistically significant predictors of pancreatic disease: age, gender, smoking, fat intake, ACE II genotype and ACE DD genotype. However, in the multivariate analysis, only age, gender and smoking were singled out as predictors for the occurrence of pancreatic disease. Our findings indicate that the ACE I/D polymorphism could play a role in the development of chronic pancreatitis and pancreatic cancer through interaction with other genetic and environmental factors.",
publisher = "Karger, Basel",
journal = "Digestive Surgery",
title = "Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer",
volume = "28",
number = "4",
pages = "258-262",
doi = "10.1159/000328666"
}

Lukić, S., Nikolić, A., Alempijević, T., Popović, D., Sokić-Milutinović, A., Ugljesić, M., Knežević, S., Miličić, B., Dinić, D.,& Radojković, D.. (2011). Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer. in Digestive Surgery
Karger, Basel., 28(4), 258-262.
https://doi.org/10.1159/000328666

Lukić S, Nikolić A, Alempijević T, Popović D, Sokić-Milutinović A, Ugljesić M, Knežević S, Miličić B, Dinić D, Radojković D. Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer. in Digestive Surgery. 2011;28(4):258-262.
doi:10.1159/000328666 .

Lukić, Snezana, Nikolić, Aleksandra, Alempijević, Tamara, Popović, Dragan, Sokić-Milutinović, Aleksandra, Ugljesić, Milenko, Knežević, Srbislav, Miličić, Biljana, Dinić, Dragica, Radojković, Dragica, "Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism in Patients with Chronic Pancreatitis and Pancreatic Cancer" in Digestive Surgery, 28, no. 4 (2011):258-262,
https://doi.org/10.1159/000328666 . .

TY  - JOUR
AU  - Stanković-Popović, Verica
AU  - Maksić, Đoko
AU  - Vučinić, Žarko
AU  - Lepić, Toplica
AU  - Popović, Dragan
AU  - Miličić, Biljana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1453
AB  - Background/Aim. Peritoneal dialysis (PD) patients have an increased risk for cardiovascular diseases. The aim of the study was to evaluate the cardiovascular changes in patients undergoing chronic PD and the eventual existing differences depending on biocompatibility of dialysis solutions. Methods. After 3±2 years of starting PD, 21 PD patients on the treatment with bioincompatible dialysis solutions (conventional glucose- based solutions: PDP-1), average age 47.43±12.87 years, and 21 PD patients on the treatment with biocompatible dialysis solutions (neutral solutions with lower level of glucose degradation products, lower concentration of Ca2+ and neutral pH: PDP-2), average age 68.62±13.98 years, participated in the longitudinal study. The average number of episodes of peritonitis was similare in both groups: 1 episode per 36 months of the treatment. The control group included 21 patients with preterminal phase of chronic renal failure (Glomerular Filtration Rate: 22.19±10.73 ml/min), average age 65.29± 13.74 years. All the patients underwent transthoracal echocardiography (in order to detect: eject fraction (EF), left ventricular hypertrophy (LVH), and valvular calcification (VC) and B-mode ultrasonography of common carotid artery (CCA): IMT, lumen narrowing, and plaque detection. Results. The values of EF were: in PDP-1 group 62.05±5.65%, in PDP-2 group 53.43±7.47%, and in the control group 56.71±8.12% (Bonferroni test, p = 0.001). The recorded LVH was: in PDP-1 group in 47.6% of the patients; in PDP-2 group in 61.9% of the patients; and in control the group in 52.4% (χ2 test; p = 0.639). The detected VC was: in PDP-1 in 52.4% of the patients, in PDP-2 group in 42.9% of the patients, and in the control group in 23.8% of the patients (χ2 test; p = 0.776). The IMT was: in PDP-1 group 1.26±0.54 mm, in PDP-2 group 1.23±0.32, and in the control group 1.25±0.27 mm (Bonferroni test; p = 0.981). An average lumen narrowing was: in PDP-1 group 13.78±18.26%, in PDP-2 group 18.57±22.98%, and in the control group 25.00±28.02% (Kruskal Wallis test; p = 0.413). Calcified plaques of CCA were detected in PDP-1 group in 61.9% of the patients, in PDP-2 group in 85.7%, of the patients and in the control group in 81% of the patients (χ2 test; p = 0.159). Conclusion. Generally, PD had a significant influence on cardiovascular morbidity in the treated patients, especially on the left ventricular function and peripherial atherosclerosis. The age of the patients had more influence on acceleration of atherosclerosis than the length of dialysis or biocompatibility of dialysis solutions.
AB  - Uvod/Cilj. Bolesnici koji se leče peritoneumskom dijalizom (PD) imaju značajno povišen rizik od pojave kardiovaskularnih bolesti. Cilj rada bio je da se utvrde kardiovaskularne promene kod bolesnika na kontiniranoj ambulatnoj peritoneumskoj dijalizi (KAPD), kao i postojanje eventualnih razlika u njihovom prisustvu zavisno od biokompatibilnosti korišćenih rastvora za PD. Metode. Analitičkom studijom preseka obuhvaćena su ukupno 42 bolesnika lečena više od godinu dana putem KAPD (dijalizni staž: 3±2 godine). Pri tome, kod polovine bolesnika, prosečne starosti 47,43±12,87 godine, primenjivani su bioinkompatibilni rastvori za PD (kiseli standardni rastvori: PDB-1); kod druge polovine bolesnika prosečne starosti 68,62±13,98 god. primenjivani su biokompatibilniji rastvori za PD (neutralni rastvori sa znatno manjom koncentracijom degradacionih produkata glukoze, 1,25 mmol/l Ca2+ i 40 mmol/l laktata: PDB-2). Prosečan broj epizoda peritonitisa u obe grupe ispitanika bio je sličan: 1 epizoda na 36- 44 meseca lečenja. Kontrolnu grupu činio je 21 bolesnik u stadijumu III-IV hronične bubrežne insuficijencije (jačina glomerulske filtracije: 22,19±10,73 ml/min), prosečne starosti 65,29±13,74 godine. Svim bolesnicima urađena je transtoraksna ehosonografija i utvrđena ejekciona frakcija (EF) leve komore, postojanje hipertrofije leve komore (HLK) i kalcifikacije u zidu ili srčanim zaliscima (VK), kao i doplerehosonografija krvnih sudova vrata kojom se merena debljina intimomedijalnog kompleksa (IMK) nad a. carotis communis, stepen suženja lumena arterije i prisustvo kalcifikovanih aterosklerotskih plakova. Rezultati. Vrednosti EF bili su: kod PDB-1 62,05±5,65%; kod PDB-2 53,43±7,47%; u kontrolnoj grupi 56,71±8,12% (Bonferroni test, p = 0,001). HLK zabeležena je u PDB-1 grupi kod 47,6% bolesnika, u PDB-2 grupi kod 61,9% bolesnika i u kontrolnoj grupi kod 52,4% bolesnika (χ2 test; p = 0,639). Detektovane su VK kod 52,4% bolesnika u PDB-1 grupi kod 42,9% bolesnika u PDB-2 grupi i kod 23,8% bolesnika iz kontrolne grupe (χ2 test; p = 0,776). Debljina IMK iznosila je u PDB-1 grupi 1,26±0,54 mm, u PDB-2 grupi 1,23±0,32 mm i u kontrolnoj grupi 1,25±0,27 mm (Bonferroni test; p = 0,981). Stepen suženja lumena arterije: bio je u PDB-1 grupi 13,78±18,26%, u PDB-2 grupi 18,57±22,98% i u kontrolnoj grupi 25,00±28,02% (Kruskal Wallis test; p = 0,413). Kalcifikovani aterosklerotski plakovi detektovani su kod 61,9% bolesnika u PDB-1 grupi, kod 85,7% bolesnika u PDB-2 grupi i kod 81% bolesnika u kontrolnoj grupi (χ2 test; p = 0,159). Zaključak. PD dodatno doprinosi obolevanju kardiovaskularnog sistema kod bolesnika sa HBI, naročito preko uticaja na EF srca i perifernu aterosklerozu. Pri tome, starost bolesnika na KAPD u većoj meri utiče na ispoljavanje ubrzanog procesa ateroskleroze i kardiovaskularnog oboljenja nego dužina vremenskog dijaliziranja i biokompatibilnost korišćenih rastvora.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Correlation between dialysis solution type and cardiovascular morbidity rate in patients undergoing continuous ambulatory peritoneal dialysis
T1  - Povezanost vrste rastvora za dijalizu sa stepenom kardiovaskularnih promena kod bolesnika na kontinuiranoj ambulatnoj peritoneumskoj dijalizi
VL  - 65
IS  - 3
SP  - 221
EP  - 228
DO  - 10.2298/VSP0803221S
ER  - 

@article{
author = "Stanković-Popović, Verica and Maksić, Đoko and Vučinić, Žarko and Lepić, Toplica and Popović, Dragan and Miličić, Biljana",
year = "2008",
abstract = "Background/Aim. Peritoneal dialysis (PD) patients have an increased risk for cardiovascular diseases. The aim of the study was to evaluate the cardiovascular changes in patients undergoing chronic PD and the eventual existing differences depending on biocompatibility of dialysis solutions. Methods. After 3±2 years of starting PD, 21 PD patients on the treatment with bioincompatible dialysis solutions (conventional glucose- based solutions: PDP-1), average age 47.43±12.87 years, and 21 PD patients on the treatment with biocompatible dialysis solutions (neutral solutions with lower level of glucose degradation products, lower concentration of Ca2+ and neutral pH: PDP-2), average age 68.62±13.98 years, participated in the longitudinal study. The average number of episodes of peritonitis was similare in both groups: 1 episode per 36 months of the treatment. The control group included 21 patients with preterminal phase of chronic renal failure (Glomerular Filtration Rate: 22.19±10.73 ml/min), average age 65.29± 13.74 years. All the patients underwent transthoracal echocardiography (in order to detect: eject fraction (EF), left ventricular hypertrophy (LVH), and valvular calcification (VC) and B-mode ultrasonography of common carotid artery (CCA): IMT, lumen narrowing, and plaque detection. Results. The values of EF were: in PDP-1 group 62.05±5.65%, in PDP-2 group 53.43±7.47%, and in the control group 56.71±8.12% (Bonferroni test, p = 0.001). The recorded LVH was: in PDP-1 group in 47.6% of the patients; in PDP-2 group in 61.9% of the patients; and in control the group in 52.4% (χ2 test; p = 0.639). The detected VC was: in PDP-1 in 52.4% of the patients, in PDP-2 group in 42.9% of the patients, and in the control group in 23.8% of the patients (χ2 test; p = 0.776). The IMT was: in PDP-1 group 1.26±0.54 mm, in PDP-2 group 1.23±0.32, and in the control group 1.25±0.27 mm (Bonferroni test; p = 0.981). An average lumen narrowing was: in PDP-1 group 13.78±18.26%, in PDP-2 group 18.57±22.98%, and in the control group 25.00±28.02% (Kruskal Wallis test; p = 0.413). Calcified plaques of CCA were detected in PDP-1 group in 61.9% of the patients, in PDP-2 group in 85.7%, of the patients and in the control group in 81% of the patients (χ2 test; p = 0.159). Conclusion. Generally, PD had a significant influence on cardiovascular morbidity in the treated patients, especially on the left ventricular function and peripherial atherosclerosis. The age of the patients had more influence on acceleration of atherosclerosis than the length of dialysis or biocompatibility of dialysis solutions., Uvod/Cilj. Bolesnici koji se leče peritoneumskom dijalizom (PD) imaju značajno povišen rizik od pojave kardiovaskularnih bolesti. Cilj rada bio je da se utvrde kardiovaskularne promene kod bolesnika na kontiniranoj ambulatnoj peritoneumskoj dijalizi (KAPD), kao i postojanje eventualnih razlika u njihovom prisustvu zavisno od biokompatibilnosti korišćenih rastvora za PD. Metode. Analitičkom studijom preseka obuhvaćena su ukupno 42 bolesnika lečena više od godinu dana putem KAPD (dijalizni staž: 3±2 godine). Pri tome, kod polovine bolesnika, prosečne starosti 47,43±12,87 godine, primenjivani su bioinkompatibilni rastvori za PD (kiseli standardni rastvori: PDB-1); kod druge polovine bolesnika prosečne starosti 68,62±13,98 god. primenjivani su biokompatibilniji rastvori za PD (neutralni rastvori sa znatno manjom koncentracijom degradacionih produkata glukoze, 1,25 mmol/l Ca2+ i 40 mmol/l laktata: PDB-2). Prosečan broj epizoda peritonitisa u obe grupe ispitanika bio je sličan: 1 epizoda na 36- 44 meseca lečenja. Kontrolnu grupu činio je 21 bolesnik u stadijumu III-IV hronične bubrežne insuficijencije (jačina glomerulske filtracije: 22,19±10,73 ml/min), prosečne starosti 65,29±13,74 godine. Svim bolesnicima urađena je transtoraksna ehosonografija i utvrđena ejekciona frakcija (EF) leve komore, postojanje hipertrofije leve komore (HLK) i kalcifikacije u zidu ili srčanim zaliscima (VK), kao i doplerehosonografija krvnih sudova vrata kojom se merena debljina intimomedijalnog kompleksa (IMK) nad a. carotis communis, stepen suženja lumena arterije i prisustvo kalcifikovanih aterosklerotskih plakova. Rezultati. Vrednosti EF bili su: kod PDB-1 62,05±5,65%; kod PDB-2 53,43±7,47%; u kontrolnoj grupi 56,71±8,12% (Bonferroni test, p = 0,001). HLK zabeležena je u PDB-1 grupi kod 47,6% bolesnika, u PDB-2 grupi kod 61,9% bolesnika i u kontrolnoj grupi kod 52,4% bolesnika (χ2 test; p = 0,639). Detektovane su VK kod 52,4% bolesnika u PDB-1 grupi kod 42,9% bolesnika u PDB-2 grupi i kod 23,8% bolesnika iz kontrolne grupe (χ2 test; p = 0,776). Debljina IMK iznosila je u PDB-1 grupi 1,26±0,54 mm, u PDB-2 grupi 1,23±0,32 mm i u kontrolnoj grupi 1,25±0,27 mm (Bonferroni test; p = 0,981). Stepen suženja lumena arterije: bio je u PDB-1 grupi 13,78±18,26%, u PDB-2 grupi 18,57±22,98% i u kontrolnoj grupi 25,00±28,02% (Kruskal Wallis test; p = 0,413). Kalcifikovani aterosklerotski plakovi detektovani su kod 61,9% bolesnika u PDB-1 grupi, kod 85,7% bolesnika u PDB-2 grupi i kod 81% bolesnika u kontrolnoj grupi (χ2 test; p = 0,159). Zaključak. PD dodatno doprinosi obolevanju kardiovaskularnog sistema kod bolesnika sa HBI, naročito preko uticaja na EF srca i perifernu aterosklerozu. Pri tome, starost bolesnika na KAPD u većoj meri utiče na ispoljavanje ubrzanog procesa ateroskleroze i kardiovaskularnog oboljenja nego dužina vremenskog dijaliziranja i biokompatibilnost korišćenih rastvora.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Correlation between dialysis solution type and cardiovascular morbidity rate in patients undergoing continuous ambulatory peritoneal dialysis, Povezanost vrste rastvora za dijalizu sa stepenom kardiovaskularnih promena kod bolesnika na kontinuiranoj ambulatnoj peritoneumskoj dijalizi",
volume = "65",
number = "3",
pages = "221-228",
doi = "10.2298/VSP0803221S"
}

Stanković-Popović, V., Maksić, Đ., Vučinić, Ž., Lepić, T., Popović, D.,& Miličić, B.. (2008). Correlation between dialysis solution type and cardiovascular morbidity rate in patients undergoing continuous ambulatory peritoneal dialysis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 65(3), 221-228.
https://doi.org/10.2298/VSP0803221S

Stanković-Popović V, Maksić Đ, Vučinić Ž, Lepić T, Popović D, Miličić B. Correlation between dialysis solution type and cardiovascular morbidity rate in patients undergoing continuous ambulatory peritoneal dialysis. in Vojnosanitetski pregled. 2008;65(3):221-228.
doi:10.2298/VSP0803221S .

Stanković-Popović, Verica, Maksić, Đoko, Vučinić, Žarko, Lepić, Toplica, Popović, Dragan, Miličić, Biljana, "Correlation between dialysis solution type and cardiovascular morbidity rate in patients undergoing continuous ambulatory peritoneal dialysis" in Vojnosanitetski pregled, 65, no. 3 (2008):221-228,
https://doi.org/10.2298/VSP0803221S . .