TY  - JOUR
AU  - Popović, Branka
AU  - Velimirović, Milica
AU  - Stojković, Tihomir
AU  - Brajović, Gavrilo
AU  - de Luka, Silvio R.
AU  - Milovanović, Ivan
AU  - Stefanović, Srđan
AU  - Nikolić, Dragica
AU  - Ristic-Đurović, Jasna L.
AU  - Petronijević, Nataša
AU  - Trbovich, Alexander M.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2323
AB  - Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, heart, skin, and intestine. Since melatonin can influence antioxidant enzymes, the activity of superoxide dismutase (SOD) and catalase (CAT), and the level of GSH were measured in liver. In addition, Copper (Cu), Zinc (Zn), and Manganese (Mn) were also determined in liver since these microelements might affect the activity of antioxidant enzymes. The expression of AA-NAT and ASMT was increased in liver and skin of old animals. A positive correlation in AA-NAT and ASMT expression was observed in liver, intestine and kidney. Moreover, the activity of CAT enzyme in liver was increased while SOD activity was decreased. SOD and CAT were probably affected by the observed decreased amount of Cu, Zn, and Mn in liver of old animals. In our model, extrapineal melatonin pathway in ageing consisted of complex interplay of locally produced melatonin, activities of SOD and CAT, and adequate presence of Cu, Zn and Mn microelements in order to defend organs against oxidative damage.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Experimental Gerontology
T1  - The influence of ageing on the extrapineal melatonin synthetic pathway
VL  - 110
SP  - 151
EP  - 157
DO  - 10.1016/j.exger.2018.06.010
ER  - 

@article{
author = "Popović, Branka and Velimirović, Milica and Stojković, Tihomir and Brajović, Gavrilo and de Luka, Silvio R. and Milovanović, Ivan and Stefanović, Srđan and Nikolić, Dragica and Ristic-Đurović, Jasna L. and Petronijević, Nataša and Trbovich, Alexander M.",
year = "2018",
abstract = "Ageing affects various physiological and metabolic processes in a body and a progressive accumulation of oxidative damage stands out as often used explanation. One of the most powerful scavenger of reactive oxygen species (ROS) in all organs is melatonin. A majority of melatonin supplied to the body via blood originates from the pineal gland. However, we have been interested in a locally produced melatonin. We have used 2.5- and 36-months-old Wistar rats. Tissues were collected and gene expression of AA-NAT and ASMT, the two key enzymes in a synthesis of melatonin, was determined in brain, liver, kidney, heart, skin, and intestine. Since melatonin can influence antioxidant enzymes, the activity of superoxide dismutase (SOD) and catalase (CAT), and the level of GSH were measured in liver. In addition, Copper (Cu), Zinc (Zn), and Manganese (Mn) were also determined in liver since these microelements might affect the activity of antioxidant enzymes. The expression of AA-NAT and ASMT was increased in liver and skin of old animals. A positive correlation in AA-NAT and ASMT expression was observed in liver, intestine and kidney. Moreover, the activity of CAT enzyme in liver was increased while SOD activity was decreased. SOD and CAT were probably affected by the observed decreased amount of Cu, Zn, and Mn in liver of old animals. In our model, extrapineal melatonin pathway in ageing consisted of complex interplay of locally produced melatonin, activities of SOD and CAT, and adequate presence of Cu, Zn and Mn microelements in order to defend organs against oxidative damage.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Experimental Gerontology",
title = "The influence of ageing on the extrapineal melatonin synthetic pathway",
volume = "110",
pages = "151-157",
doi = "10.1016/j.exger.2018.06.010"
}

Popović, B., Velimirović, M., Stojković, T., Brajović, G., de Luka, S. R., Milovanović, I., Stefanović, S., Nikolić, D., Ristic-Đurović, J. L., Petronijević, N.,& Trbovich, A. M.. (2018). The influence of ageing on the extrapineal melatonin synthetic pathway. in Experimental Gerontology
Pergamon-Elsevier Science Ltd, Oxford., 110, 151-157.
https://doi.org/10.1016/j.exger.2018.06.010

Popović B, Velimirović M, Stojković T, Brajović G, de Luka SR, Milovanović I, Stefanović S, Nikolić D, Ristic-Đurović JL, Petronijević N, Trbovich AM. The influence of ageing on the extrapineal melatonin synthetic pathway. in Experimental Gerontology. 2018;110:151-157.
doi:10.1016/j.exger.2018.06.010 .

Popović, Branka, Velimirović, Milica, Stojković, Tihomir, Brajović, Gavrilo, de Luka, Silvio R., Milovanović, Ivan, Stefanović, Srđan, Nikolić, Dragica, Ristic-Đurović, Jasna L., Petronijević, Nataša, Trbovich, Alexander M., "The influence of ageing on the extrapineal melatonin synthetic pathway" in Experimental Gerontology, 110 (2018):151-157,
https://doi.org/10.1016/j.exger.2018.06.010 . .

TY  - JOUR
AU  - Latas, Milan
AU  - Stojković, Tihomir
AU  - Ralić, Tijana
AU  - Jovanović, Svetlana
AU  - Špirić, Željko
AU  - Milovanović, Srđan
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1905
AB  - Background/Aim. Previous studies on medical students' subjective perception of health and health-related quality of life (HRQoL) showed inconclusive results. Moreover, there are no published studies to compare HRQoL of medical students to non-medical university students. The aim of the study was to assess subjective perception of health-related quality of life (HRQoL) in medical students' sample, to compare it with non-medical university stu-dents and to ascertain predictors of better perception of HRQoL in medical students. Methods. Scores of all domains on the Mental and Physical Component Summary subscales and total score of the Short Form Health Survey (SF-36), used for assessment of HRQoL in samples of 561 medical and 332 non-medical university students were assessed and compared. In addition, linear regression to identify predictors of better perception of mental and physical components of HRQoL and overall HRQoL in the sample of medical students was used. The dependant variables were subscores and total score with the SF- 36, and independent variables were certain sociodemographic and academic characteristics of the students. Results. Medical students had statistically significantly higher scores on the Mental Component Summary and total SF-36 score compared to non-medical students. Linear regression analysis demonstrated that higher scores of Physical Component Summary were associated with age, male sex and the year of studies. The Mental Component Summary were associated with age, male sex, the year of studies and marital status. The total SF-36 score was associated with age, male sex and the year of studies. Conclusion. Medical students perceive their health much better than other university students do, but female, older and second grade medical students have worse perception of their HRQoL. Those points should be potential target areas for specific prevention and treatment in order to achieve better HRQoL.
AB  - Uvod/Cilj. Dosadašnje studije subjektivne percepcije zdravlja i kvaliteta života povezanog sa zdravstvenim stanjem (HRQoL) studenata medicine pokazale su kontradiktorne rezultate. Štaviše, ne postoje objavljene studije koje su poredile HRQoL studenata medicine i studenata ne- medicinskih fakulteta. Cilj ove studije bio je da se proceni subjektivna percepcija HRQoL na uzorku studenata medicine, da se uporedi sa percepcijom HRQoL studenata ne- medicinskih fakulteta i da se utvrde prediktori bolje percepcije HRQoL kod studenata medicine. Metode. Uzorak za istraživanje obuhvatio je 561 studenta medicine i 332 studenta ne-medicinskih fakulteta Univerziteta u Beogradu. Istraživanje je obavljeno uz pomoć Short Form Health Survey (SF-36) upitnika koji procenjuje mentalnu i fizičku komponentu, kao i ukupan skor subjektivne procene kvaliteta života vezanog za zdravstveno stanje. Upoređeni su skorovi sa zbirne skale i supskala dve grupe studenata. Pored toga, korišćena je i linearna regresija da bi se procenili prediktori boljeg sagledavanja ukupnog skora i mentalne i fizičke komponente HRQoL na uzorku studenata medicine. Zavisne varijable bile su supskorovi i ukupan skor sa SF- 36 upitnika, a nezavisne varijable sociodemografske i akademske karakteristike ispitanika. Rezultati. Studenti medicine imali su statistički značajno više skorove na supskali mentalnog zdravlja i na ukupnom skoru SF-36 upitnika u odnosu na studente ne-medicinskih fakulteta. Linearna regresija pokazala je da su viši skorovi fizičke komponente povezani sa godinama starosti, muškim polom i godinom studija; viši skorovi mentalne komponente povezani sa godinama starosti, muškim polom, godinom studija i bračnim statusom. Ukupan SF-36 skor povezan je sa godinama starosti, muškim polom i godinom studija. Zaključak. Studenti medicine gledaju na svoje zdravstveno stanje mnogo bolje nego studenti ne-medicinskih fakulteta. Ipak, devojke, stariji studenti i studenti druge godine medicine imaju lošiju percepciju svog kvaliteta života koji se vezuje za zdravlje. Ovo bi trebalo da budu fokusi za specifičnu prevenciju i eventualnu terapiju u cilju postizanja boljeg kvaliteta života studenata medicine.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Medical students' health-related quality of life: A comparative study
T1  - Kvalitet života povezan sa zdravstvenim stanjem studenata medicine - komparativna studija
VL  - 71
IS  - 8
SP  - 751
EP  - 756
DO  - 10.2298/VSP1408751L
ER  - 

@article{
author = "Latas, Milan and Stojković, Tihomir and Ralić, Tijana and Jovanović, Svetlana and Špirić, Željko and Milovanović, Srđan",
year = "2014",
abstract = "Background/Aim. Previous studies on medical students' subjective perception of health and health-related quality of life (HRQoL) showed inconclusive results. Moreover, there are no published studies to compare HRQoL of medical students to non-medical university students. The aim of the study was to assess subjective perception of health-related quality of life (HRQoL) in medical students' sample, to compare it with non-medical university stu-dents and to ascertain predictors of better perception of HRQoL in medical students. Methods. Scores of all domains on the Mental and Physical Component Summary subscales and total score of the Short Form Health Survey (SF-36), used for assessment of HRQoL in samples of 561 medical and 332 non-medical university students were assessed and compared. In addition, linear regression to identify predictors of better perception of mental and physical components of HRQoL and overall HRQoL in the sample of medical students was used. The dependant variables were subscores and total score with the SF- 36, and independent variables were certain sociodemographic and academic characteristics of the students. Results. Medical students had statistically significantly higher scores on the Mental Component Summary and total SF-36 score compared to non-medical students. Linear regression analysis demonstrated that higher scores of Physical Component Summary were associated with age, male sex and the year of studies. The Mental Component Summary were associated with age, male sex, the year of studies and marital status. The total SF-36 score was associated with age, male sex and the year of studies. Conclusion. Medical students perceive their health much better than other university students do, but female, older and second grade medical students have worse perception of their HRQoL. Those points should be potential target areas for specific prevention and treatment in order to achieve better HRQoL., Uvod/Cilj. Dosadašnje studije subjektivne percepcije zdravlja i kvaliteta života povezanog sa zdravstvenim stanjem (HRQoL) studenata medicine pokazale su kontradiktorne rezultate. Štaviše, ne postoje objavljene studije koje su poredile HRQoL studenata medicine i studenata ne- medicinskih fakulteta. Cilj ove studije bio je da se proceni subjektivna percepcija HRQoL na uzorku studenata medicine, da se uporedi sa percepcijom HRQoL studenata ne- medicinskih fakulteta i da se utvrde prediktori bolje percepcije HRQoL kod studenata medicine. Metode. Uzorak za istraživanje obuhvatio je 561 studenta medicine i 332 studenta ne-medicinskih fakulteta Univerziteta u Beogradu. Istraživanje je obavljeno uz pomoć Short Form Health Survey (SF-36) upitnika koji procenjuje mentalnu i fizičku komponentu, kao i ukupan skor subjektivne procene kvaliteta života vezanog za zdravstveno stanje. Upoređeni su skorovi sa zbirne skale i supskala dve grupe studenata. Pored toga, korišćena je i linearna regresija da bi se procenili prediktori boljeg sagledavanja ukupnog skora i mentalne i fizičke komponente HRQoL na uzorku studenata medicine. Zavisne varijable bile su supskorovi i ukupan skor sa SF- 36 upitnika, a nezavisne varijable sociodemografske i akademske karakteristike ispitanika. Rezultati. Studenti medicine imali su statistički značajno više skorove na supskali mentalnog zdravlja i na ukupnom skoru SF-36 upitnika u odnosu na studente ne-medicinskih fakulteta. Linearna regresija pokazala je da su viši skorovi fizičke komponente povezani sa godinama starosti, muškim polom i godinom studija; viši skorovi mentalne komponente povezani sa godinama starosti, muškim polom, godinom studija i bračnim statusom. Ukupan SF-36 skor povezan je sa godinama starosti, muškim polom i godinom studija. Zaključak. Studenti medicine gledaju na svoje zdravstveno stanje mnogo bolje nego studenti ne-medicinskih fakulteta. Ipak, devojke, stariji studenti i studenti druge godine medicine imaju lošiju percepciju svog kvaliteta života koji se vezuje za zdravlje. Ovo bi trebalo da budu fokusi za specifičnu prevenciju i eventualnu terapiju u cilju postizanja boljeg kvaliteta života studenata medicine.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Medical students' health-related quality of life: A comparative study, Kvalitet života povezan sa zdravstvenim stanjem studenata medicine - komparativna studija",
volume = "71",
number = "8",
pages = "751-756",
doi = "10.2298/VSP1408751L"
}

Latas, M., Stojković, T., Ralić, T., Jovanović, S., Špirić, Ž.,& Milovanović, S.. (2014). Medical students' health-related quality of life: A comparative study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(8), 751-756.
https://doi.org/10.2298/VSP1408751L

Latas M, Stojković T, Ralić T, Jovanović S, Špirić Ž, Milovanović S. Medical students' health-related quality of life: A comparative study. in Vojnosanitetski pregled. 2014;71(8):751-756.
doi:10.2298/VSP1408751L .

Latas, Milan, Stojković, Tihomir, Ralić, Tijana, Jovanović, Svetlana, Špirić, Željko, Milovanović, Srđan, "Medical students' health-related quality of life: A comparative study" in Vojnosanitetski pregled, 71, no. 8 (2014):751-756,
https://doi.org/10.2298/VSP1408751L . .