TY  - JOUR
AU  - Hadži-Mihailović, Miloš
AU  - Raybaud, Helene
AU  - Montei, R.
AU  - Čakić, Saša
AU  - Đurić, M.
AU  - Janković, Ljiljana
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1591
AB  - Purpose: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell carcinoma (SCC), and to establish potential interdependence between expression of Bcl-2 and the different clinical and histopathological parameters in H, OLP, and SCC. Methods: Immunohistochemistry for Bcl-2 was carried out using an avidin-biotin peroxidase complex method. Tissue sections were treated with mouse monoclonal antibody against Bcl-2 (124, DAKO A/S, Denmark; dilution 1/100). Immunohistochemical parameters measured included total tissue area, total stained area and intensity of stain. Results: Keratinocytes were not Bcl-2 positive in H and were sparsely positive in OLP. The number of lymphocytes stained with Bcl-2 was significantly lower in Has compared to patients with SCC and OLP. Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC. Bcl-2-positive lymphocytes were more expressed in older OLP patients (>55 years), and in OLP specimens with orthokeratinized epithelium, less developed acanthosis and highest grade of lymphocyte expression. Conclusion: Bcl-2 may not serve as a prognostic biomarker in oral cancer development from OLP, but it could help in selecting patients with higher need of follow up to prevent malignancy.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus
VL  - 15
IS  - 2
SP  - 362
EP  - 368
UR  - https://hdl.handle.net/21.15107/rcub_smile_1591
ER  - 

@article{
author = "Hadži-Mihailović, Miloš and Raybaud, Helene and Montei, R. and Čakić, Saša and Đurić, M. and Janković, Ljiljana",
year = "2010",
abstract = "Purpose: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell carcinoma (SCC), and to establish potential interdependence between expression of Bcl-2 and the different clinical and histopathological parameters in H, OLP, and SCC. Methods: Immunohistochemistry for Bcl-2 was carried out using an avidin-biotin peroxidase complex method. Tissue sections were treated with mouse monoclonal antibody against Bcl-2 (124, DAKO A/S, Denmark; dilution 1/100). Immunohistochemical parameters measured included total tissue area, total stained area and intensity of stain. Results: Keratinocytes were not Bcl-2 positive in H and were sparsely positive in OLP. The number of lymphocytes stained with Bcl-2 was significantly lower in Has compared to patients with SCC and OLP. Bcl-2 staining was weak to moderate in OLP, and moderate to intense in SCC. Bcl-2-positive lymphocytes were more expressed in older OLP patients (>55 years), and in OLP specimens with orthokeratinized epithelium, less developed acanthosis and highest grade of lymphocyte expression. Conclusion: Bcl-2 may not serve as a prognostic biomarker in oral cancer development from OLP, but it could help in selecting patients with higher need of follow up to prevent malignancy.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus",
volume = "15",
number = "2",
pages = "362-368",
url = "https://hdl.handle.net/21.15107/rcub_smile_1591"
}

Hadži-Mihailović, M., Raybaud, H., Montei, R., Čakić, S., Đurić, M.,& Janković, L.. (2010). Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 15(2), 362-368.
https://hdl.handle.net/21.15107/rcub_smile_1591

Hadži-Mihailović M, Raybaud H, Montei R, Čakić S, Đurić M, Janković L. Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus. in Journal of BUON. 2010;15(2):362-368.
https://hdl.handle.net/21.15107/rcub_smile_1591 .

Hadži-Mihailović, Miloš, Raybaud, Helene, Montei, R., Čakić, Saša, Đurić, M., Janković, Ljiljana, "Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus" in Journal of BUON, 15, no. 2 (2010):362-368,
https://hdl.handle.net/21.15107/rcub_smile_1591 .