TY  - JOUR
AU  - Velicković, Jelena
AU  - Palibrk, Ivan
AU  - Miličić, Biljana
AU  - Velicković, Dejan
AU  - Jovanović, Bojan
AU  - Rakić, Goran
AU  - Petrović, Milorad
AU  - Bumbaširević, Vesna
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2461
AB  - Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L-0], at 4 hours (L-4), 12 hours (L-12), and 24 hours (L-24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge or death. Receiver operating characteristic (ROC) curves were used to determine the predictive value of lactate levels for postoperative outcomes. The best cut-off lactate values were calculated to differentiate between patients with and without complications, and outcomes in patients with lactate levels above and below the cut-off thresholds were compared. Univariate and multivariate analyses were used to identify variables associated with POCs and mortality. Seventy-six patients developed 184 complications (18 deaths), while 119 had no complications. Serum lactate levels were higher in patients with complications at all time points compared to those without complications (p  lt  0.001). L-12 had the highest predictive value for complications (AUROC(12) = 0.787; 95% CI: 0.719-0.854; p  lt  0.001) and mortality (AUROC(12) = 0.872; 95% CI: 0.794-0.950;p  lt  0.00l). The best L-12 cut-off value for complications and mortality was 1.35 mmol/l and 1.85 mmol/l, respectively. Multivariate analysis revealed that L-1(2) >= 1.35 mml/l was an independent predictor of postoperative morbidity (OR 2.58; 95% CI 1.27-5.24,p = 0.001) . L-24 was predictive of POCs after major abdominal surgery. L-12 had the best power to discriminate between patients with and without POCs and was associated with a longer hospital stay.
PB  - Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
T2  - Bosnian Journal of Basic Medical Sciences
T1  - The association of early postoperative lactate levels with morbidity after elective major abdominal surgery
VL  - 19
IS  - 1
SP  - 72
EP  - 80
DO  - 10.17305/bjbms.2018.3186
ER  - 

@article{
author = "Velicković, Jelena and Palibrk, Ivan and Miličić, Biljana and Velicković, Dejan and Jovanović, Bojan and Rakić, Goran and Petrović, Milorad and Bumbaširević, Vesna",
year = "2019",
abstract = "Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L-0], at 4 hours (L-4), 12 hours (L-12), and 24 hours (L-24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge or death. Receiver operating characteristic (ROC) curves were used to determine the predictive value of lactate levels for postoperative outcomes. The best cut-off lactate values were calculated to differentiate between patients with and without complications, and outcomes in patients with lactate levels above and below the cut-off thresholds were compared. Univariate and multivariate analyses were used to identify variables associated with POCs and mortality. Seventy-six patients developed 184 complications (18 deaths), while 119 had no complications. Serum lactate levels were higher in patients with complications at all time points compared to those without complications (p  lt  0.001). L-12 had the highest predictive value for complications (AUROC(12) = 0.787; 95% CI: 0.719-0.854; p  lt  0.001) and mortality (AUROC(12) = 0.872; 95% CI: 0.794-0.950;p  lt  0.00l). The best L-12 cut-off value for complications and mortality was 1.35 mmol/l and 1.85 mmol/l, respectively. Multivariate analysis revealed that L-1(2) >= 1.35 mml/l was an independent predictor of postoperative morbidity (OR 2.58; 95% CI 1.27-5.24,p = 0.001) . L-24 was predictive of POCs after major abdominal surgery. L-12 had the best power to discriminate between patients with and without POCs and was associated with a longer hospital stay.",
publisher = "Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery",
volume = "19",
number = "1",
pages = "72-80",
doi = "10.17305/bjbms.2018.3186"
}

Velicković, J., Palibrk, I., Miličić, B., Velicković, D., Jovanović, B., Rakić, G., Petrović, M.,& Bumbaširević, V.. (2019). The association of early postoperative lactate levels with morbidity after elective major abdominal surgery. in Bosnian Journal of Basic Medical Sciences
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa., 19(1), 72-80.
https://doi.org/10.17305/bjbms.2018.3186

Velicković J, Palibrk I, Miličić B, Velicković D, Jovanović B, Rakić G, Petrović M, Bumbaširević V. The association of early postoperative lactate levels with morbidity after elective major abdominal surgery. in Bosnian Journal of Basic Medical Sciences. 2019;19(1):72-80.
doi:10.17305/bjbms.2018.3186 .

Velicković, Jelena, Palibrk, Ivan, Miličić, Biljana, Velicković, Dejan, Jovanović, Bojan, Rakić, Goran, Petrović, Milorad, Bumbaširević, Vesna, "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery" in Bosnian Journal of Basic Medical Sciences, 19, no. 1 (2019):72-80,
https://doi.org/10.17305/bjbms.2018.3186 . .