TY  - JOUR
AU  - Dragašević, Sanja
AU  - Sokić-Milutinović, Aleksandra
AU  - Stojković-Lalošević, Milica
AU  - Milovanović, Tamara
AU  - Đuranović, Srđan
AU  - Jovanović, Ivan
AU  - Rajić, Sanja
AU  - Stojković, Mirjana
AU  - Miličić, Biljana
AU  - Kmezić, Stefan
AU  - Oluić, Branislav
AU  - Aleksić, Marko
AU  - Pavlović-Marković, Aleksandra
AU  - Popović, Dragan
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2507
AB  - Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.
PB  - Hindawi Ltd, London
T2  - Gastroenterology Research & Practice
T1  - Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients
VL  - 2020
DO  - 10.1155/2020/2065383
ER  - 

@article{
author = "Dragašević, Sanja and Sokić-Milutinović, Aleksandra and Stojković-Lalošević, Milica and Milovanović, Tamara and Đuranović, Srđan and Jovanović, Ivan and Rajić, Sanja and Stojković, Mirjana and Miličić, Biljana and Kmezić, Stefan and Oluić, Branislav and Aleksić, Marko and Pavlović-Marković, Aleksandra and Popović, Dragan",
year = "2020",
abstract = "Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.",
publisher = "Hindawi Ltd, London",
journal = "Gastroenterology Research & Practice",
title = "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients",
volume = "2020",
doi = "10.1155/2020/2065383"
}

Dragašević, S., Sokić-Milutinović, A., Stojković-Lalošević, M., Milovanović, T., Đuranović, S., Jovanović, I., Rajić, S., Stojković, M., Miličić, B., Kmezić, S., Oluić, B., Aleksić, M., Pavlović-Marković, A.,& Popović, D.. (2020). Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice
Hindawi Ltd, London., 2020.
https://doi.org/10.1155/2020/2065383

Dragašević S, Sokić-Milutinović A, Stojković-Lalošević M, Milovanović T, Đuranović S, Jovanović I, Rajić S, Stojković M, Miličić B, Kmezić S, Oluić B, Aleksić M, Pavlović-Marković A, Popović D. Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice. 2020;2020.
doi:10.1155/2020/2065383 .

Dragašević, Sanja, Sokić-Milutinović, Aleksandra, Stojković-Lalošević, Milica, Milovanović, Tamara, Đuranović, Srđan, Jovanović, Ivan, Rajić, Sanja, Stojković, Mirjana, Miličić, Biljana, Kmezić, Stefan, Oluić, Branislav, Aleksić, Marko, Pavlović-Marković, Aleksandra, Popović, Dragan, "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients" in Gastroenterology Research & Practice, 2020 (2020),
https://doi.org/10.1155/2020/2065383 . .

TY  - JOUR
AU  - Smolović, Brigita
AU  - Stanisavljević, Dejana
AU  - Golubović, Mileta
AU  - Vučković, Ljiljana
AU  - Miličić, Biljana
AU  - Đuranović, Srđan
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1910
AB  - Background/Aim. A high risk of bleeding in Helicobacter pylori (H.pylori)-negative, non-steroidal anti-inflammatory drugs (NSAID)-negative ulcers highlights the clinical importance of analysis of the changing trends of peptic ulcer disease. The aim of the study was to investigate the risk factors for ulcer bleeding in patients with non-H. pylori infection, and with no NSAIDs use. Methods. A prospective study included patients with endoscopically diagnosed ulcer disease. The patients were without H. pylori infection (verified by pathohistology and serology) and without exposure to NSAIDs and proton pump inhibitors (PPI) within 4 weeks before endoscopy. After endoscopy the patients were divided into 2 groups: the study group of 48 patients with bleeding ulcer and the control group of 47 patients with ulcer, but with no bleeding. Prior to endoscopy they had completed a questionnaire about demographics, risk factors and habits. The platelet function, von Willebrand factor (vWF) and blood groups were determined. Histopathological analysis of biopsy samples were performed with a modified Sydney system. The influence of bile reflux was analyzed by Bile reflux index (BRI). Results. Age, gender, tobacco and alcohol use did not affect the bleeding rate. The risk of bleeding did not depend on concomitant diseases (p = 0.509) and exposure to stress (p = 0.944). Aspirin was used by 16/48 (33.3%) patients with bleeding ulcer, as opposed to 7/47 (14.9%) patients who did not bleed (p = 0.036). Abnormal platelet function had 12/48 (25.0%) patients who bled, as opposed to 2/47 (4.3%) patients who did not bleed (p = 0.004). Patients with BRI  lt  14 bled in 79.2%, and did not bleed in 57.4% of the cases (p = 0.023). There was no statistical difference between groups in regards to blood groups and range of vWF. Antrum atrophy was found in 14/48 (29.2%) patients with bleeding ulcer and in only 5/47 (10.6%) patients who had ulcer without bleeding (p = 0.024). Conclusion. Abnormal platelet function, aspirin use and antrum atrophy were the risk factors for ulcer bleeding in non-H. pylori, non- NSAIDs ulcer disease.
AB  - Uvod/Cilj. Visoki rizik od krvarenja Helicobacter pylori (H. pylori)-negativnih i sa nesteroidnim inflamatornim lekovima (NSAIL)-negativnih ulkusa potencirao je klinički značaj analiziranja novih tendencija peptičke ulkusne bolesti. Cilj ove studije bio je ispitati faktore rizika od nastanka krvarećeg ulkusa kod bolesnika bez H. pylori infekcije i bez upotrebe NSAIL. Metode. Prospektivna studija obuhvatala je bolesnike sa endoskopski dijagnostikovanom ulkusnom bolešću. Bolesnici su bili bez H. pylori infekcije (potvrđeno patohistološki i serološki) i bez upotrebe NSAIL i inhibitora protonske pumpe (IPP) tokom četiri nedelje pre endoskopije. Posle endoskopije bolesnici su bili podeljeni u dve grupe: studijsku grupu od 48 bolesnika sa krvarećim ulkusom i kontrolnu grupu od 47 bolesnika sa ulkusom bez krvarenja. Pre endoskopije bolesnici su popunjavali upitnik o demografskim podacima, faktorima rizika i navikama. Funkcija trombocita, von Willebrand faktor (vWF) i krvne grupe ispitivane su, takođe. Patohistološki su analizirani biopsijski uzorci po modifikovanom Sydnejskom sistemu. Uticaj bilijarnog refluksa analiziran je pomoću bilijarnog refluksnog indeksa (BRI). Rezultati. Godine, pol, pušenje i upotreba alkohola nisu imali uticaj na stopu krvarenja. Rizik od krvarenja nije zavisio od udruženih bolesti (p = 0,509), niti od izloženosti stresu (p = 0,944). Aspirin je uzimalo 16/48 (33,3%) bolesnika sa krvarećim ulkusom, u poredeđenju sa 7/47 (14.9%) bolesnika koji nisu krvarili (p = 0,036). Abnormalnu funkciju trombocita imalo je 12/48 (25,0%) bolesnika sa krvarenjem, u poređenju sa 2/47 (4,3%) bolesnika koji nisu krvarili (p = 0,004). Bolesnici sa BRI  lt  14 krvarili su u 79,2%, a nisu krvarili u 57,4% slučajeva (p = 0,023). Nije bilo statistički značajne razlike između dve grupe u odnosu na krvne grupe i nivo vWF. Antralna atrofija nađena je kod 14/48 (29,2%) bolesnika sa krvarećim ulkusom i kod 5/47 (10,6%) bolesnika koji su imali ulkus bez krvarenja (p = 0,024). Zaključak. Abnormalna funkcija trombocita, upotreba aspirina i antralna atrofija jesu faktori rizika od krvarenja kod H. pylori-negativne i NSAIL-negativne ulkusne bolesti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs
T1  - Krvareći gastroduodenalni ulkusi kod bolesnika bez Helicobacter pylori infekcije i bez upotrebe nesteroidnih antiinflamatornih lekova
VL  - 71
IS  - 2
SP  - 183
EP  - 190
DO  - 10.2298/VSP1402183S
ER  - 

@article{
author = "Smolović, Brigita and Stanisavljević, Dejana and Golubović, Mileta and Vučković, Ljiljana and Miličić, Biljana and Đuranović, Srđan",
year = "2014",
abstract = "Background/Aim. A high risk of bleeding in Helicobacter pylori (H.pylori)-negative, non-steroidal anti-inflammatory drugs (NSAID)-negative ulcers highlights the clinical importance of analysis of the changing trends of peptic ulcer disease. The aim of the study was to investigate the risk factors for ulcer bleeding in patients with non-H. pylori infection, and with no NSAIDs use. Methods. A prospective study included patients with endoscopically diagnosed ulcer disease. The patients were without H. pylori infection (verified by pathohistology and serology) and without exposure to NSAIDs and proton pump inhibitors (PPI) within 4 weeks before endoscopy. After endoscopy the patients were divided into 2 groups: the study group of 48 patients with bleeding ulcer and the control group of 47 patients with ulcer, but with no bleeding. Prior to endoscopy they had completed a questionnaire about demographics, risk factors and habits. The platelet function, von Willebrand factor (vWF) and blood groups were determined. Histopathological analysis of biopsy samples were performed with a modified Sydney system. The influence of bile reflux was analyzed by Bile reflux index (BRI). Results. Age, gender, tobacco and alcohol use did not affect the bleeding rate. The risk of bleeding did not depend on concomitant diseases (p = 0.509) and exposure to stress (p = 0.944). Aspirin was used by 16/48 (33.3%) patients with bleeding ulcer, as opposed to 7/47 (14.9%) patients who did not bleed (p = 0.036). Abnormal platelet function had 12/48 (25.0%) patients who bled, as opposed to 2/47 (4.3%) patients who did not bleed (p = 0.004). Patients with BRI  lt  14 bled in 79.2%, and did not bleed in 57.4% of the cases (p = 0.023). There was no statistical difference between groups in regards to blood groups and range of vWF. Antrum atrophy was found in 14/48 (29.2%) patients with bleeding ulcer and in only 5/47 (10.6%) patients who had ulcer without bleeding (p = 0.024). Conclusion. Abnormal platelet function, aspirin use and antrum atrophy were the risk factors for ulcer bleeding in non-H. pylori, non- NSAIDs ulcer disease., Uvod/Cilj. Visoki rizik od krvarenja Helicobacter pylori (H. pylori)-negativnih i sa nesteroidnim inflamatornim lekovima (NSAIL)-negativnih ulkusa potencirao je klinički značaj analiziranja novih tendencija peptičke ulkusne bolesti. Cilj ove studije bio je ispitati faktore rizika od nastanka krvarećeg ulkusa kod bolesnika bez H. pylori infekcije i bez upotrebe NSAIL. Metode. Prospektivna studija obuhvatala je bolesnike sa endoskopski dijagnostikovanom ulkusnom bolešću. Bolesnici su bili bez H. pylori infekcije (potvrđeno patohistološki i serološki) i bez upotrebe NSAIL i inhibitora protonske pumpe (IPP) tokom četiri nedelje pre endoskopije. Posle endoskopije bolesnici su bili podeljeni u dve grupe: studijsku grupu od 48 bolesnika sa krvarećim ulkusom i kontrolnu grupu od 47 bolesnika sa ulkusom bez krvarenja. Pre endoskopije bolesnici su popunjavali upitnik o demografskim podacima, faktorima rizika i navikama. Funkcija trombocita, von Willebrand faktor (vWF) i krvne grupe ispitivane su, takođe. Patohistološki su analizirani biopsijski uzorci po modifikovanom Sydnejskom sistemu. Uticaj bilijarnog refluksa analiziran je pomoću bilijarnog refluksnog indeksa (BRI). Rezultati. Godine, pol, pušenje i upotreba alkohola nisu imali uticaj na stopu krvarenja. Rizik od krvarenja nije zavisio od udruženih bolesti (p = 0,509), niti od izloženosti stresu (p = 0,944). Aspirin je uzimalo 16/48 (33,3%) bolesnika sa krvarećim ulkusom, u poredeđenju sa 7/47 (14.9%) bolesnika koji nisu krvarili (p = 0,036). Abnormalnu funkciju trombocita imalo je 12/48 (25,0%) bolesnika sa krvarenjem, u poređenju sa 2/47 (4,3%) bolesnika koji nisu krvarili (p = 0,004). Bolesnici sa BRI  lt  14 krvarili su u 79,2%, a nisu krvarili u 57,4% slučajeva (p = 0,023). Nije bilo statistički značajne razlike između dve grupe u odnosu na krvne grupe i nivo vWF. Antralna atrofija nađena je kod 14/48 (29,2%) bolesnika sa krvarećim ulkusom i kod 5/47 (10,6%) bolesnika koji su imali ulkus bez krvarenja (p = 0,024). Zaključak. Abnormalna funkcija trombocita, upotreba aspirina i antralna atrofija jesu faktori rizika od krvarenja kod H. pylori-negativne i NSAIL-negativne ulkusne bolesti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs, Krvareći gastroduodenalni ulkusi kod bolesnika bez Helicobacter pylori infekcije i bez upotrebe nesteroidnih antiinflamatornih lekova",
volume = "71",
number = "2",
pages = "183-190",
doi = "10.2298/VSP1402183S"
}

Smolović, B., Stanisavljević, D., Golubović, M., Vučković, L., Miličić, B.,& Đuranović, S.. (2014). Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(2), 183-190.
https://doi.org/10.2298/VSP1402183S

Smolović B, Stanisavljević D, Golubović M, Vučković L, Miličić B, Đuranović S. Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs. in Vojnosanitetski pregled. 2014;71(2):183-190.
doi:10.2298/VSP1402183S .

Smolović, Brigita, Stanisavljević, Dejana, Golubović, Mileta, Vučković, Ljiljana, Miličić, Biljana, Đuranović, Srđan, "Bleeding gastroduodenal ulcers in patients without Helicobacter pylori infection and without exposure to non-steroidal anti-inflammatory drugs" in Vojnosanitetski pregled, 71, no. 2 (2014):183-190,
https://doi.org/10.2298/VSP1402183S . .