TY  - JOUR
AU  - Velicković, Jelena
AU  - Palibrk, Ivan
AU  - Miličić, Biljana
AU  - Velicković, Dejan
AU  - Jovanović, Bojan
AU  - Rakić, Goran
AU  - Petrović, Milorad
AU  - Bumbaširević, Vesna
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2461
AB  - Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L-0], at 4 hours (L-4), 12 hours (L-12), and 24 hours (L-24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge or death. Receiver operating characteristic (ROC) curves were used to determine the predictive value of lactate levels for postoperative outcomes. The best cut-off lactate values were calculated to differentiate between patients with and without complications, and outcomes in patients with lactate levels above and below the cut-off thresholds were compared. Univariate and multivariate analyses were used to identify variables associated with POCs and mortality. Seventy-six patients developed 184 complications (18 deaths), while 119 had no complications. Serum lactate levels were higher in patients with complications at all time points compared to those without complications (p  lt  0.001). L-12 had the highest predictive value for complications (AUROC(12) = 0.787; 95% CI: 0.719-0.854; p  lt  0.001) and mortality (AUROC(12) = 0.872; 95% CI: 0.794-0.950;p  lt  0.00l). The best L-12 cut-off value for complications and mortality was 1.35 mmol/l and 1.85 mmol/l, respectively. Multivariate analysis revealed that L-1(2) >= 1.35 mml/l was an independent predictor of postoperative morbidity (OR 2.58; 95% CI 1.27-5.24,p = 0.001) . L-24 was predictive of POCs after major abdominal surgery. L-12 had the best power to discriminate between patients with and without POCs and was associated with a longer hospital stay.
PB  - Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
T2  - Bosnian Journal of Basic Medical Sciences
T1  - The association of early postoperative lactate levels with morbidity after elective major abdominal surgery
VL  - 19
IS  - 1
SP  - 72
EP  - 80
DO  - 10.17305/bjbms.2018.3186
ER  - 

@article{
author = "Velicković, Jelena and Palibrk, Ivan and Miličić, Biljana and Velicković, Dejan and Jovanović, Bojan and Rakić, Goran and Petrović, Milorad and Bumbaširević, Vesna",
year = "2019",
abstract = "Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L-0], at 4 hours (L-4), 12 hours (L-12), and 24 hours (L-24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge or death. Receiver operating characteristic (ROC) curves were used to determine the predictive value of lactate levels for postoperative outcomes. The best cut-off lactate values were calculated to differentiate between patients with and without complications, and outcomes in patients with lactate levels above and below the cut-off thresholds were compared. Univariate and multivariate analyses were used to identify variables associated with POCs and mortality. Seventy-six patients developed 184 complications (18 deaths), while 119 had no complications. Serum lactate levels were higher in patients with complications at all time points compared to those without complications (p  lt  0.001). L-12 had the highest predictive value for complications (AUROC(12) = 0.787; 95% CI: 0.719-0.854; p  lt  0.001) and mortality (AUROC(12) = 0.872; 95% CI: 0.794-0.950;p  lt  0.00l). The best L-12 cut-off value for complications and mortality was 1.35 mmol/l and 1.85 mmol/l, respectively. Multivariate analysis revealed that L-1(2) >= 1.35 mml/l was an independent predictor of postoperative morbidity (OR 2.58; 95% CI 1.27-5.24,p = 0.001) . L-24 was predictive of POCs after major abdominal surgery. L-12 had the best power to discriminate between patients with and without POCs and was associated with a longer hospital stay.",
publisher = "Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery",
volume = "19",
number = "1",
pages = "72-80",
doi = "10.17305/bjbms.2018.3186"
}

Velicković, J., Palibrk, I., Miličić, B., Velicković, D., Jovanović, B., Rakić, G., Petrović, M.,& Bumbaširević, V.. (2019). The association of early postoperative lactate levels with morbidity after elective major abdominal surgery. in Bosnian Journal of Basic Medical Sciences
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa., 19(1), 72-80.
https://doi.org/10.17305/bjbms.2018.3186

Velicković J, Palibrk I, Miličić B, Velicković D, Jovanović B, Rakić G, Petrović M, Bumbaširević V. The association of early postoperative lactate levels with morbidity after elective major abdominal surgery. in Bosnian Journal of Basic Medical Sciences. 2019;19(1):72-80.
doi:10.17305/bjbms.2018.3186 .

Velicković, Jelena, Palibrk, Ivan, Miličić, Biljana, Velicković, Dejan, Jovanović, Bojan, Rakić, Goran, Petrović, Milorad, Bumbaširević, Vesna, "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery" in Bosnian Journal of Basic Medical Sciences, 19, no. 1 (2019):72-80,
https://doi.org/10.17305/bjbms.2018.3186 . .

TY  - JOUR
AU  - Palibrk, Ivan
AU  - Miličić, Biljana
AU  - Stojiljković, Ljuba
AU  - Manojlović, Nebojša
AU  - Dugalić, Vladimir
AU  - Bumbaširević, Vesna
AU  - Kalezić, Nevena
AU  - Žuvela, Marinko
AU  - Milicević, Miroslav
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1736
AB  - Background/Aims: Liver resection is the gold standard in managing patients with metastatic or primary liver cancer. The aim of our study was to compare the traditional clamp-crushing technique to the radiofrequency-assisted liver resection technique in terms of postoperative liver function. Methodology: Liver function was evaluated preoperatively and on postoperative days 3 and 7. Liver synthetic function parameters (serum albumin level, prothrombin time and international normalized ratio), markers of hepatic injury and necrosis (serum alanine aminotransferase, aspartate aminotransferase and total bilirubin level) and microsomal activity (quantitative lidocaine test) were compared. Results: Forty three patients completed the study (14 had clamp-crushing and 29 had radiofrequency assisted liver resection). The groups did not differ in demographic characteristics, pre-operative liver function, operative time and perioperative transfusion rate. In postoperative period, there were similar changes in monitored parameters in both groups except albumin levels, that were higher in radiofrequency-assisted liver resection group (p=0.047). Conclusions: Both, traditional clamp-crushing technique and radiofrequency assisted liver resection technique, result in similar postoperative changes of most monitored liver function parameters.
PB  - H G E Update Medical Publishing S A, Athens
T2  - Hepato-Gastroenterology
T1  - Clamp-Crushing vs. Radiofrequency-Assisted Liver Resection: Changes in Liver Function Tests
VL  - 59
IS  - 115
SP  - 800
EP  - 804
DO  - 10.5754/hge11539
ER  - 

@article{
author = "Palibrk, Ivan and Miličić, Biljana and Stojiljković, Ljuba and Manojlović, Nebojša and Dugalić, Vladimir and Bumbaširević, Vesna and Kalezić, Nevena and Žuvela, Marinko and Milicević, Miroslav",
year = "2012",
abstract = "Background/Aims: Liver resection is the gold standard in managing patients with metastatic or primary liver cancer. The aim of our study was to compare the traditional clamp-crushing technique to the radiofrequency-assisted liver resection technique in terms of postoperative liver function. Methodology: Liver function was evaluated preoperatively and on postoperative days 3 and 7. Liver synthetic function parameters (serum albumin level, prothrombin time and international normalized ratio), markers of hepatic injury and necrosis (serum alanine aminotransferase, aspartate aminotransferase and total bilirubin level) and microsomal activity (quantitative lidocaine test) were compared. Results: Forty three patients completed the study (14 had clamp-crushing and 29 had radiofrequency assisted liver resection). The groups did not differ in demographic characteristics, pre-operative liver function, operative time and perioperative transfusion rate. In postoperative period, there were similar changes in monitored parameters in both groups except albumin levels, that were higher in radiofrequency-assisted liver resection group (p=0.047). Conclusions: Both, traditional clamp-crushing technique and radiofrequency assisted liver resection technique, result in similar postoperative changes of most monitored liver function parameters.",
publisher = "H G E Update Medical Publishing S A, Athens",
journal = "Hepato-Gastroenterology",
title = "Clamp-Crushing vs. Radiofrequency-Assisted Liver Resection: Changes in Liver Function Tests",
volume = "59",
number = "115",
pages = "800-804",
doi = "10.5754/hge11539"
}

Palibrk, I., Miličić, B., Stojiljković, L., Manojlović, N., Dugalić, V., Bumbaširević, V., Kalezić, N., Žuvela, M.,& Milicević, M.. (2012). Clamp-Crushing vs. Radiofrequency-Assisted Liver Resection: Changes in Liver Function Tests. in Hepato-Gastroenterology
H G E Update Medical Publishing S A, Athens., 59(115), 800-804.
https://doi.org/10.5754/hge11539

Palibrk I, Miličić B, Stojiljković L, Manojlović N, Dugalić V, Bumbaširević V, Kalezić N, Žuvela M, Milicević M. Clamp-Crushing vs. Radiofrequency-Assisted Liver Resection: Changes in Liver Function Tests. in Hepato-Gastroenterology. 2012;59(115):800-804.
doi:10.5754/hge11539 .

Palibrk, Ivan, Miličić, Biljana, Stojiljković, Ljuba, Manojlović, Nebojša, Dugalić, Vladimir, Bumbaširević, Vesna, Kalezić, Nevena, Žuvela, Marinko, Milicević, Miroslav, "Clamp-Crushing vs. Radiofrequency-Assisted Liver Resection: Changes in Liver Function Tests" in Hepato-Gastroenterology, 59, no. 115 (2012):800-804,
https://doi.org/10.5754/hge11539 . .