Boričić, Ivan

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Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis

Milovanović, Tamara; Copertino, Ana; Boričić, Ivan; Miličić, Biljana; Pavlović-Marković, Aleksandra; Krstić, Miodrag; Matović, Vera; Popović, Dušan Đ.

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2018)

TY  - JOUR
AU  - Milovanović, Tamara
AU  - Copertino, Ana
AU  - Boričić, Ivan
AU  - Miličić, Biljana
AU  - Pavlović-Marković, Aleksandra
AU  - Krstić, Miodrag
AU  - Matović, Vera
AU  - Popović, Dušan Đ.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2294
AB  - In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p  lt  0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures.
AB  - Prethodnih decenija otkrivene su neinvanzivne metode za procenu i praćenje fibroze jetre kod hroničnih bolesti jetre. Cilj ove studije bila je procena dijagnostičke preciznosti neinvanzivnih metoda za određivanje fibroze jetre [tranzijentna elastografija (TE) i biohemijski markeri], pri čemu je kao zlatni standard korišćena biopsija jetre kod bolesnika sa primarnom bilijarnom cirozom. Metode. U studiju su bila uključena 122 bolesnika kod kojih su istog dana urađene biohemijske analize i biopsija jetre, a mesec dana kasnije urađena je TE. Za procenu fibroze jetre korišćen je METAVIR skor, a sve preparate biopsija proverio je jedan patolog. APRI skor - odnos aspartat aminotransferaze (AST) i trombocita, Forns indeks, odnos AST i alanin transaminaze (ALT) i TE poređene su sa stepenom fiboze jetre dobijene na osnovu biopsija jetre u cilju dobijanja najboljeg neinvanzivnog markera u proceni fibroze jetre. Rezultati. Dokazana je statistička značajnost (p  lt  0.05) za APRI skor, Forns indeks i TE za procenu stepena fibroze jetre. TE je imala najbolji dijagnostički učinak u poređenju sa ostalim markerima koje smo istraživali. Optimalne granične vrednosti za TE bile su 4.25 i 5.9 kPa za dijagnozu fibroze jetre i razlikovanje slabe/umerene i uznapredovale fibroze. Površina ispod krive operativnih karakteristka (AUROC) za TE bila je 0.963 i 0.865. Zaključak. Na osnovu rezultata ove studije proizilazili su APRI skor, Forns indeks i TE adekvatni dijagnostički markeri fibroze jetre kod bolesnika sa primarnom biijarnom cirozom, ali je TE najsenzitivniji i najspecifičniji parametar. Koristeći neinvanzivne parametre i metode u svakodnevnoj kliničkoj praksi može se smanjiti, ali ne i potpuno izbaciti, potreba za invanzivnim dijagnostičkim procedurama.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis
T1  - Tranzijentna elastografija u neinvazivnoj proceni fibroze jetre kod bolesnika sa primarnom bilijarnom cirozom
VL  - 75
IS  - 4
SP  - 374
EP  - 379
DO  - 10.2298/VSP160409337A
ER  - 
@article{
author = "Milovanović, Tamara and Copertino, Ana and Boričić, Ivan and Miličić, Biljana and Pavlović-Marković, Aleksandra and Krstić, Miodrag and Matović, Vera and Popović, Dušan Đ.",
year = "2018",
abstract = "In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p  lt  0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures., Prethodnih decenija otkrivene su neinvanzivne metode za procenu i praćenje fibroze jetre kod hroničnih bolesti jetre. Cilj ove studije bila je procena dijagnostičke preciznosti neinvanzivnih metoda za određivanje fibroze jetre [tranzijentna elastografija (TE) i biohemijski markeri], pri čemu je kao zlatni standard korišćena biopsija jetre kod bolesnika sa primarnom bilijarnom cirozom. Metode. U studiju su bila uključena 122 bolesnika kod kojih su istog dana urađene biohemijske analize i biopsija jetre, a mesec dana kasnije urađena je TE. Za procenu fibroze jetre korišćen je METAVIR skor, a sve preparate biopsija proverio je jedan patolog. APRI skor - odnos aspartat aminotransferaze (AST) i trombocita, Forns indeks, odnos AST i alanin transaminaze (ALT) i TE poređene su sa stepenom fiboze jetre dobijene na osnovu biopsija jetre u cilju dobijanja najboljeg neinvanzivnog markera u proceni fibroze jetre. Rezultati. Dokazana je statistička značajnost (p  lt  0.05) za APRI skor, Forns indeks i TE za procenu stepena fibroze jetre. TE je imala najbolji dijagnostički učinak u poređenju sa ostalim markerima koje smo istraživali. Optimalne granične vrednosti za TE bile su 4.25 i 5.9 kPa za dijagnozu fibroze jetre i razlikovanje slabe/umerene i uznapredovale fibroze. Površina ispod krive operativnih karakteristka (AUROC) za TE bila je 0.963 i 0.865. Zaključak. Na osnovu rezultata ove studije proizilazili su APRI skor, Forns indeks i TE adekvatni dijagnostički markeri fibroze jetre kod bolesnika sa primarnom biijarnom cirozom, ali je TE najsenzitivniji i najspecifičniji parametar. Koristeći neinvanzivne parametre i metode u svakodnevnoj kliničkoj praksi može se smanjiti, ali ne i potpuno izbaciti, potreba za invanzivnim dijagnostičkim procedurama.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis, Tranzijentna elastografija u neinvazivnoj proceni fibroze jetre kod bolesnika sa primarnom bilijarnom cirozom",
volume = "75",
number = "4",
pages = "374-379",
doi = "10.2298/VSP160409337A"
}
Milovanović, T., Copertino, A., Boričić, I., Miličić, B., Pavlović-Marković, A., Krstić, M., Matović, V.,& Popović, D. Đ.. (2018). Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(4), 374-379.
https://doi.org/10.2298/VSP160409337A
Milovanović T, Copertino A, Boričić I, Miličić B, Pavlović-Marković A, Krstić M, Matović V, Popović DĐ. Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis. in Vojnosanitetski pregled. 2018;75(4):374-379.
doi:10.2298/VSP160409337A .
Milovanović, Tamara, Copertino, Ana, Boričić, Ivan, Miličić, Biljana, Pavlović-Marković, Aleksandra, Krstić, Miodrag, Matović, Vera, Popović, Dušan Đ., "Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis" in Vojnosanitetski pregled, 75, no. 4 (2018):374-379,
https://doi.org/10.2298/VSP160409337A . .
2
1

Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters

Dožić, Branko; Glumac, Sofija; Boricić, Novica; Dozić, Marko; Aničić, Boban; Boričić, Ivan

(Balkan Union of Oncology (B.U.ON.), 2016)

TY  - JOUR
AU  - Dožić, Branko
AU  - Glumac, Sofija
AU  - Boricić, Novica
AU  - Dozić, Marko
AU  - Aničić, Boban
AU  - Boričić, Ivan
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2141
AB  - Purpose: Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. It is characterized by a high rate of recurrence, perineural invasion and development of distant metastases many years after removal of the primary tumor. Disorders of the induction of apoptosis and its cascade reactions where caspases are involved may be significant in the pathogenesis of this tumor. Methods: The immunohistochemical expression of caspase 9 and caspase 3 was analyzed by tissue microarray (TMA) in 50 cases of ACC in relation with different clinicopathological parameters (gender, age, localization, histological type and overall survival). Results: Caspase 9 was expressed in the cytoplasm and nuclei of ACC tumor cells with varying degrees of staining intensity (1+, 6%; 2+, 54%, 3+, 40%). Comparison of caspase 9 expression in tumor cells with clinicopathological parameters (gender, age, localization, histological type and overall survival) showed no statistically significant difference except that the expression was more pronounced in females. Caspase 3 was expressed in the cytoplasm of tumor cells with varying degrees of staining intensity (1+, 22%; 2+, 36%; 3+, 42%). No correlation between the expression of caspase 3 and clinicopathological parameters was noticed. Conclusions: The expression of caspases 9 and 3 in ACC of the salivary glands can contribute in the better characterization of molecules involved in apoptosis of tumor cells.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters
VL  - 21
IS  - 1
SP  - 152
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_smile_2141
ER  - 
@article{
author = "Dožić, Branko and Glumac, Sofija and Boricić, Novica and Dozić, Marko and Aničić, Boban and Boričić, Ivan",
year = "2016",
abstract = "Purpose: Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. It is characterized by a high rate of recurrence, perineural invasion and development of distant metastases many years after removal of the primary tumor. Disorders of the induction of apoptosis and its cascade reactions where caspases are involved may be significant in the pathogenesis of this tumor. Methods: The immunohistochemical expression of caspase 9 and caspase 3 was analyzed by tissue microarray (TMA) in 50 cases of ACC in relation with different clinicopathological parameters (gender, age, localization, histological type and overall survival). Results: Caspase 9 was expressed in the cytoplasm and nuclei of ACC tumor cells with varying degrees of staining intensity (1+, 6%; 2+, 54%, 3+, 40%). Comparison of caspase 9 expression in tumor cells with clinicopathological parameters (gender, age, localization, histological type and overall survival) showed no statistically significant difference except that the expression was more pronounced in females. Caspase 3 was expressed in the cytoplasm of tumor cells with varying degrees of staining intensity (1+, 22%; 2+, 36%; 3+, 42%). No correlation between the expression of caspase 3 and clinicopathological parameters was noticed. Conclusions: The expression of caspases 9 and 3 in ACC of the salivary glands can contribute in the better characterization of molecules involved in apoptosis of tumor cells.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters",
volume = "21",
number = "1",
pages = "152-160",
url = "https://hdl.handle.net/21.15107/rcub_smile_2141"
}
Dožić, B., Glumac, S., Boricić, N., Dozić, M., Aničić, B.,& Boričić, I.. (2016). Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(1), 152-160.
https://hdl.handle.net/21.15107/rcub_smile_2141
Dožić B, Glumac S, Boricić N, Dozić M, Aničić B, Boričić I. Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters. in Journal of BUON. 2016;21(1):152-160.
https://hdl.handle.net/21.15107/rcub_smile_2141 .
Dožić, Branko, Glumac, Sofija, Boricić, Novica, Dozić, Marko, Aničić, Boban, Boričić, Ivan, "Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters" in Journal of BUON, 21, no. 1 (2016):152-160,
https://hdl.handle.net/21.15107/rcub_smile_2141 .
1

The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer

Radunović, Milena; Nikolić, Nadja; Milenković, Sanja; Tomanović, Nada; Boričić, Ivan; Dimitrijević, Milovan; Novaković, Ivana; Basta-Jovanović, Gordana

(Balkan Union of Oncology (B.U.ON.), 2016)

TY  - JOUR
AU  - Radunović, Milena
AU  - Nikolić, Nadja
AU  - Milenković, Sanja
AU  - Tomanović, Nada
AU  - Boričić, Ivan
AU  - Dimitrijević, Milovan
AU  - Novaković, Ivana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2178
AB  - Purpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer
VL  - 21
IS  - 3
SP  - 597
EP  - 602
UR  - https://hdl.handle.net/21.15107/rcub_smile_2178
ER  - 
@article{
author = "Radunović, Milena and Nikolić, Nadja and Milenković, Sanja and Tomanović, Nada and Boričić, Ivan and Dimitrijević, Milovan and Novaković, Ivana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer",
volume = "21",
number = "3",
pages = "597-602",
url = "https://hdl.handle.net/21.15107/rcub_smile_2178"
}
Radunović, M., Nikolić, N., Milenković, S., Tomanović, N., Boričić, I., Dimitrijević, M., Novaković, I.,& Basta-Jovanović, G.. (2016). The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(3), 597-602.
https://hdl.handle.net/21.15107/rcub_smile_2178
Radunović M, Nikolić N, Milenković S, Tomanović N, Boričić I, Dimitrijević M, Novaković I, Basta-Jovanović G. The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer. in Journal of BUON. 2016;21(3):597-602.
https://hdl.handle.net/21.15107/rcub_smile_2178 .
Radunović, Milena, Nikolić, Nadja, Milenković, Sanja, Tomanović, Nada, Boričić, Ivan, Dimitrijević, Milovan, Novaković, Ivana, Basta-Jovanović, Gordana, "The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer" in Journal of BUON, 21, no. 3 (2016):597-602,
https://hdl.handle.net/21.15107/rcub_smile_2178 .
12

Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer

Radunović, Milena; Tomanović, Nada; Novaković, Ivana; Boričić, Ivan; Milenković, Sanja; Dimitrijević, Milovan; Radojević-Škodrić, Sanja; Bogdanović, Ljiljana; Basta-Jovanović, Gordana

(Balkan Union of Oncology (B.U.ON.), 2016)

TY  - JOUR
AU  - Radunović, Milena
AU  - Tomanović, Nada
AU  - Novaković, Ivana
AU  - Boričić, Ivan
AU  - Milenković, Sanja
AU  - Dimitrijević, Milovan
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, Ljiljana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2077
AB  - Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer
VL  - 21
IS  - 6
SP  - 1530
EP  - 1536
UR  - https://hdl.handle.net/21.15107/rcub_smile_2077
ER  - 
@article{
author = "Radunović, Milena and Tomanović, Nada and Novaković, Ivana and Boričić, Ivan and Milenković, Sanja and Dimitrijević, Milovan and Radojević-Škodrić, Sanja and Bogdanović, Ljiljana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer",
volume = "21",
number = "6",
pages = "1530-1536",
url = "https://hdl.handle.net/21.15107/rcub_smile_2077"
}
Radunović, M., Tomanović, N., Novaković, I., Boričić, I., Milenković, S., Dimitrijević, M., Radojević-Škodrić, S., Bogdanović, L.,& Basta-Jovanović, G.. (2016). Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(6), 1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077
Radunović M, Tomanović N, Novaković I, Boričić I, Milenković S, Dimitrijević M, Radojević-Škodrić S, Bogdanović L, Basta-Jovanović G. Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON. 2016;21(6):1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077 .
Radunović, Milena, Tomanović, Nada, Novaković, Ivana, Boričić, Ivan, Milenković, Sanja, Dimitrijević, Milovan, Radojević-Škodrić, Sanja, Bogdanović, Ljiljana, Basta-Jovanović, Gordana, "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer" in Journal of BUON, 21, no. 6 (2016):1530-1536,
https://hdl.handle.net/21.15107/rcub_smile_2077 .
4