TY  - JOUR
AU  - Mraović, Tatjana
AU  - Radaković, Sonja
AU  - Ristić-Medić, Danijela
AU  - Tepšić-Ostojić, Vesna
AU  - Rađen, Slavica
AU  - Hajduković, Zoran
AU  - Čairović, Aleksandra
AU  - Miljanović, Gora
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2356
AB  - Background/Aim. Obesity is an established risk factor for numerous chronic diseases. The aim of this study was to investigate the effect of well-balanced different caloric restriction (CR) diets on anthropometric parameters and standard biochemical cardiovascular risk markers [lipid profile, glucose homeostasis and high sensitivity C-reactive protein (hs-CRP)] in overweight/obese females. Methods. Participants (age 20-40 years) were randomized into 3 different CR diet groups: the group I - restriction of 20% calories from baseline energy requirements, the group II - restriction of 50% calories from baseline energy requirements and the group III - alternating daily diets with 70%/30% restriction. The study lasted 42 weeks. Anthropometric parameters were measured at the start and after 4, 8, 20 and 42 weeks after dietary intervention beginning. Biochemical markers were determined at baseline and after 20 and 42 weeks from dietary restriction start. Results. Body weight, body mass index (BMI), waist circumference (WC) and body fat (in %), in the different CR diet groups significantly decreased after 42 weeks. Body weight was less 11 kg in the group I and 12 kg in the groups II and III. WC was reduced by 11 cm in the groups I and III and by 10 cm in the group II. Different CR diets had the same effects on body fat (a reduction of 15% of body fat). Total cholesterol decreased by 7% in the group I and by 8% in the group III. Low density lipoprotein (LDL) cholesterol decreased by 14% in the group I and by 13% in group III. There were no significant changes in total and LDL-cholesterol levels in the group II. The atherogenic index presented as trigliceride/high density lipoprotein (TG/HDL) ratio decreased by 0.22 in the group I, by 0.25 in the group II and by 0.32 in the group III. Various CR diets had the same effects on reducing the hs-CRP levels. Conclusion. Different CR diets with the same macronutrient content are equally effective in reducing body weight, WC and body fat, improve cardiometabolic risk factors and decrease level of proinflammatory hs-CRP in overweight/obese females.
AB  - Uvod/Cilj. Gojaznost je faktor rizika od nastanka mnogih hroničnih bolesti. Cilj istraživanja bio je da se ispita efekat dobro izbalansirane ishrane različitih kalorijskih ograničenja na antropometrijske parametare i standardne biohemijske kardiovaskularne markere rizika [(lipidni profil, homeostazu glukoze, visoko senzitivni C-reaktivni protein - high-sensitivity C-reactive protein (hs-CRP)] kod predgojaznih/gojaznih žena. Metode. Ukupno 97 žena, između 20 i 40 godina starosti, konzumirale su uravnotežene, kalorijski različite restriktivne dijete, na sledeći način: I grupa (n = 37) - ograničenje 20% kalorija od osnovnih energetskih potreba; II grupa (n = 30) - ograničenje od 50% kalorija od osnovnih energetskih potreba i III grupa (n = 30) - naizmenična dnevna restrikcija od 70% i 30% kalorija od osnovnih energetskih potreba. Stepen uhranjenosti je određivan antropometrijskim merenjima na početku i nakon 4, 8, 20 i 42 nedelje od uvođenja dijeta. Biohemijski markeri analizirani su na početku i nakon 4, 8, 20 i 42 nedelje. Rezultati. Kalorijski različite restriktivne dijete dovele su do značajnog smanjena telesne mase, indeksa telesne mase (body mass index - BMI), obima struka (OS) i % telesne masti nakon tretmana od 42 nedelje. Telesna masa snižena je za 11 kg u grupi I, a za 12 kg u grupama II i III. Za 11 cm je smanjen OS u grupama I i III i za 10 cm u grupi II. Gubitak 15% ukupne telesne masti ostvaren je za sve vrste dijeta nezavisno od različitog kalorijskog unosa. Koncentracija ukupnog i (low density lipoprotein) holesterola (LDL-holesterola) snižena je za 7% i 14% u grupi I i za 8% i 13% u grupi III. Dijeta sa redukcijom kalorijskog unosa od 50% nije imala efekta na nivo ukupnog i lipoprotein niske gustine LDL-holesterola. Aterogeni indeks predstavljen kao odnos trigliceridi/lipoprotein visoke gustine (high density lipoprotein) - TG/HDL bio je manji za 0,22 u grupi I, za 0,25 u grupi II i za 0,32 u grupi III. Kalorijski različite restriktivne dijete dovele su do istog sniženja nivoa hs-CRP. Zaključak. Restriktivne vrste dijeta sa različitim kalorijskim unosom i sa istim procentom zastupljenosti makronutrijenata jednako su efikasne u smanjenju telesne mase, OS i % telesne masti, dovode do poboljšanja faktora kardiometaboličkog rizika i smanjenja proinflamatornog hs-CRP kod predgojaznih/gojaznih žena.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - The effects of different caloric restriction diets on anthropometric and cardiometabolic risk factors in overweight and obese females
T1  - Uticaj različitih kalorijskih ograničenja u ishrani na antropometrijske i kardiometaboličke faktore rizika kod predgojaznih i gojaznih žena
VL  - 75
IS  - 1
SP  - 30
EP  - 38
DO  - 10.2298/VSP160408206M
ER  - 

@article{
author = "Mraović, Tatjana and Radaković, Sonja and Ristić-Medić, Danijela and Tepšić-Ostojić, Vesna and Rađen, Slavica and Hajduković, Zoran and Čairović, Aleksandra and Miljanović, Gora",
year = "2018",
abstract = "Background/Aim. Obesity is an established risk factor for numerous chronic diseases. The aim of this study was to investigate the effect of well-balanced different caloric restriction (CR) diets on anthropometric parameters and standard biochemical cardiovascular risk markers [lipid profile, glucose homeostasis and high sensitivity C-reactive protein (hs-CRP)] in overweight/obese females. Methods. Participants (age 20-40 years) were randomized into 3 different CR diet groups: the group I - restriction of 20% calories from baseline energy requirements, the group II - restriction of 50% calories from baseline energy requirements and the group III - alternating daily diets with 70%/30% restriction. The study lasted 42 weeks. Anthropometric parameters were measured at the start and after 4, 8, 20 and 42 weeks after dietary intervention beginning. Biochemical markers were determined at baseline and after 20 and 42 weeks from dietary restriction start. Results. Body weight, body mass index (BMI), waist circumference (WC) and body fat (in %), in the different CR diet groups significantly decreased after 42 weeks. Body weight was less 11 kg in the group I and 12 kg in the groups II and III. WC was reduced by 11 cm in the groups I and III and by 10 cm in the group II. Different CR diets had the same effects on body fat (a reduction of 15% of body fat). Total cholesterol decreased by 7% in the group I and by 8% in the group III. Low density lipoprotein (LDL) cholesterol decreased by 14% in the group I and by 13% in group III. There were no significant changes in total and LDL-cholesterol levels in the group II. The atherogenic index presented as trigliceride/high density lipoprotein (TG/HDL) ratio decreased by 0.22 in the group I, by 0.25 in the group II and by 0.32 in the group III. Various CR diets had the same effects on reducing the hs-CRP levels. Conclusion. Different CR diets with the same macronutrient content are equally effective in reducing body weight, WC and body fat, improve cardiometabolic risk factors and decrease level of proinflammatory hs-CRP in overweight/obese females., Uvod/Cilj. Gojaznost je faktor rizika od nastanka mnogih hroničnih bolesti. Cilj istraživanja bio je da se ispita efekat dobro izbalansirane ishrane različitih kalorijskih ograničenja na antropometrijske parametare i standardne biohemijske kardiovaskularne markere rizika [(lipidni profil, homeostazu glukoze, visoko senzitivni C-reaktivni protein - high-sensitivity C-reactive protein (hs-CRP)] kod predgojaznih/gojaznih žena. Metode. Ukupno 97 žena, između 20 i 40 godina starosti, konzumirale su uravnotežene, kalorijski različite restriktivne dijete, na sledeći način: I grupa (n = 37) - ograničenje 20% kalorija od osnovnih energetskih potreba; II grupa (n = 30) - ograničenje od 50% kalorija od osnovnih energetskih potreba i III grupa (n = 30) - naizmenična dnevna restrikcija od 70% i 30% kalorija od osnovnih energetskih potreba. Stepen uhranjenosti je određivan antropometrijskim merenjima na početku i nakon 4, 8, 20 i 42 nedelje od uvođenja dijeta. Biohemijski markeri analizirani su na početku i nakon 4, 8, 20 i 42 nedelje. Rezultati. Kalorijski različite restriktivne dijete dovele su do značajnog smanjena telesne mase, indeksa telesne mase (body mass index - BMI), obima struka (OS) i % telesne masti nakon tretmana od 42 nedelje. Telesna masa snižena je za 11 kg u grupi I, a za 12 kg u grupama II i III. Za 11 cm je smanjen OS u grupama I i III i za 10 cm u grupi II. Gubitak 15% ukupne telesne masti ostvaren je za sve vrste dijeta nezavisno od različitog kalorijskog unosa. Koncentracija ukupnog i (low density lipoprotein) holesterola (LDL-holesterola) snižena je za 7% i 14% u grupi I i za 8% i 13% u grupi III. Dijeta sa redukcijom kalorijskog unosa od 50% nije imala efekta na nivo ukupnog i lipoprotein niske gustine LDL-holesterola. Aterogeni indeks predstavljen kao odnos trigliceridi/lipoprotein visoke gustine (high density lipoprotein) - TG/HDL bio je manji za 0,22 u grupi I, za 0,25 u grupi II i za 0,32 u grupi III. Kalorijski različite restriktivne dijete dovele su do istog sniženja nivoa hs-CRP. Zaključak. Restriktivne vrste dijeta sa različitim kalorijskim unosom i sa istim procentom zastupljenosti makronutrijenata jednako su efikasne u smanjenju telesne mase, OS i % telesne masti, dovode do poboljšanja faktora kardiometaboličkog rizika i smanjenja proinflamatornog hs-CRP kod predgojaznih/gojaznih žena.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "The effects of different caloric restriction diets on anthropometric and cardiometabolic risk factors in overweight and obese females, Uticaj različitih kalorijskih ograničenja u ishrani na antropometrijske i kardiometaboličke faktore rizika kod predgojaznih i gojaznih žena",
volume = "75",
number = "1",
pages = "30-38",
doi = "10.2298/VSP160408206M"
}

Mraović, T., Radaković, S., Ristić-Medić, D., Tepšić-Ostojić, V., Rađen, S., Hajduković, Z., Čairović, A.,& Miljanović, G.. (2018). The effects of different caloric restriction diets on anthropometric and cardiometabolic risk factors in overweight and obese females. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(1), 30-38.
https://doi.org/10.2298/VSP160408206M

Mraović T, Radaković S, Ristić-Medić D, Tepšić-Ostojić V, Rađen S, Hajduković Z, Čairović A, Miljanović G. The effects of different caloric restriction diets on anthropometric and cardiometabolic risk factors in overweight and obese females. in Vojnosanitetski pregled. 2018;75(1):30-38.
doi:10.2298/VSP160408206M .

Mraović, Tatjana, Radaković, Sonja, Ristić-Medić, Danijela, Tepšić-Ostojić, Vesna, Rađen, Slavica, Hajduković, Zoran, Čairović, Aleksandra, Miljanović, Gora, "The effects of different caloric restriction diets on anthropometric and cardiometabolic risk factors in overweight and obese females" in Vojnosanitetski pregled, 75, no. 1 (2018):30-38,
https://doi.org/10.2298/VSP160408206M . .

TY  - JOUR
AU  - Mraović, Tatjana
AU  - Radaković, Sonja
AU  - Ristić-Medić, Danijela
AU  - Dinčić, Dragan
AU  - Tepšić-Ostojić, Vesna
AU  - Čairović, Aleksandra
AU  - Miljanović, Gora
AU  - Rađen, Slavica
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2330
AB  - Background/Aim. Overweight/obesity has become important health problem in developed countries. It may be related to a presence of low-grade inflammation in white adipose tissue. The aim of this study was to investigate the levels of inflammatory marker C-reactive protein (CRP) and its relation to anthropometric parameters in overweight and obese females. Methods. This study included 200 apparently healthy, overweight and obese women (18-45 years). Their standard and alternative anthropometric parameters [body mass index (BMI), percentage of fat (%F), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI)] were determined and correlated to serum CRP concentration. Results. Average CRP level was 5.56 ± 2.43 mg/L, and it significantly positively correlated to all investigated anthropometric parameters. There was significant difference between overweight and obese group in all investigated anthropometric parameters, as well as in CRP values. When investigated separately, according to BMI, values regarding obese females showed significant correlation between CRP and every investigated anthropometric parameter. In overweight subjects, no such correlation was recorded. In the obese group, all investigated parameters were significantly related to F. In overweight subjects, body weight (BW), BMI, WC and WHtR showed significant relation to F. Conclusion. The significant difference between the overweight and obese group in all parameters of central obesity was found as well as in the CRP levels. In the obese group, we found strong correlation between adiposity measured by fat percentage and parameters of central obesity, while in the overweight group WHR and BAI did not correlate to fat percentage. Our results confirmed that CRP is a valuable marker of metabolic risk in obese females, and BMI, although not so new, is still reliable parameter of adiposity.
AB  - Uvod/Cilj. Prekomerna telesna masa i gojaznost postali su značajan zdravstveni problem u razvijenim zemljama, a mogu biti povezani sa prisustvom hronične inflamacije niskog intenziteta u belom masnom tkivu. Cilj rada bio je da se ispitaju nivoi markera inflamacije, C-reaktivnog proteina (CRP), i njegova povezanost sa standardnim antropometrijskim parametrima kod predgojaznih i gojaznih žena. Metode. Studijom je bilo obuhvaćeno 200 zdravih žena (18-45 god) kojima su određeni standardni i alternativni antropometrijski parametari [indeks telesne mase (BMI), procenat masti (%F), obim struka (WC), odnos obima struka i kukova (WHR), odnos obima struka i visine (WHtR), kao i indeks telesne masnoće (BAI)] koji su zatim korelisani sa koncentracijama CRP u serumu. Rezultati. Prosečna vrednost nivoa CRP u serumu u celoj grupi iznosila je 5,56 ± 2,43 mg/L i utvrđena je njegova značajna pozitivna korelacija sa svim ispitivanim antropometrijskim parametrima. Uočena je statistički značajna razlika između grupa predgojaznih i gojaznih žena u svim ispitivanim antropometrijskim parametrima, kao i u pogledu koncentracije CRP. U grupi gojaznih ispitanica utvrđena je značajna povezanost između CRP i svih antropometrijskih parametara, dok u predgojaznoj grupi nije zabeležena statistička značajnost. U grupi gojaznih, svi antropometrijski pokazatelji pokazali su značajnu korelaciju sa procentom telesne masti, a kod predgojaznih žena, korelacija je bila značajna samo za telesnu masu, BMI, WC i WHtR. Zaključak. Između predgojaznih i gojaznih ispitanica postoji značajna razlika u pogledu svih pokazatelja centralne gojaznosti, kao i u pogledu koncentacije CRP u serumu. U grupi gojaznih, pokazana je značajna korelacija između sadržaja masti, izraženog kao procenat masnoće, i svih pokazatelja visceralne distribucije masti, dok u grupi predgojaznih značajna povezanost nije urađena za WHR i BAI. Naši rezultati potvrđuju da CRP može predstavljati značajan marker metaboličkog rizika kod gojaznih žena, kao i da je BMI, iako spada u tradicionalne parametre, i dalje pouzdan pokazatelj sadržaja telesne masti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - The relationship between adiposity parameters and C-reactive protein values in overweight and obese women
T1  - Odnos između parametara gojaznosti i vrednosti C-reaktivnog proteina kod predgojaznih i gojaznih žena
VL  - 75
IS  - 2
SP  - 185
EP  - 190
DO  - 10.2298/VSP160419208M
ER  - 

@article{
author = "Mraović, Tatjana and Radaković, Sonja and Ristić-Medić, Danijela and Dinčić, Dragan and Tepšić-Ostojić, Vesna and Čairović, Aleksandra and Miljanović, Gora and Rađen, Slavica",
year = "2018",
abstract = "Background/Aim. Overweight/obesity has become important health problem in developed countries. It may be related to a presence of low-grade inflammation in white adipose tissue. The aim of this study was to investigate the levels of inflammatory marker C-reactive protein (CRP) and its relation to anthropometric parameters in overweight and obese females. Methods. This study included 200 apparently healthy, overweight and obese women (18-45 years). Their standard and alternative anthropometric parameters [body mass index (BMI), percentage of fat (%F), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), body adiposity index (BAI)] were determined and correlated to serum CRP concentration. Results. Average CRP level was 5.56 ± 2.43 mg/L, and it significantly positively correlated to all investigated anthropometric parameters. There was significant difference between overweight and obese group in all investigated anthropometric parameters, as well as in CRP values. When investigated separately, according to BMI, values regarding obese females showed significant correlation between CRP and every investigated anthropometric parameter. In overweight subjects, no such correlation was recorded. In the obese group, all investigated parameters were significantly related to F. In overweight subjects, body weight (BW), BMI, WC and WHtR showed significant relation to F. Conclusion. The significant difference between the overweight and obese group in all parameters of central obesity was found as well as in the CRP levels. In the obese group, we found strong correlation between adiposity measured by fat percentage and parameters of central obesity, while in the overweight group WHR and BAI did not correlate to fat percentage. Our results confirmed that CRP is a valuable marker of metabolic risk in obese females, and BMI, although not so new, is still reliable parameter of adiposity., Uvod/Cilj. Prekomerna telesna masa i gojaznost postali su značajan zdravstveni problem u razvijenim zemljama, a mogu biti povezani sa prisustvom hronične inflamacije niskog intenziteta u belom masnom tkivu. Cilj rada bio je da se ispitaju nivoi markera inflamacije, C-reaktivnog proteina (CRP), i njegova povezanost sa standardnim antropometrijskim parametrima kod predgojaznih i gojaznih žena. Metode. Studijom je bilo obuhvaćeno 200 zdravih žena (18-45 god) kojima su određeni standardni i alternativni antropometrijski parametari [indeks telesne mase (BMI), procenat masti (%F), obim struka (WC), odnos obima struka i kukova (WHR), odnos obima struka i visine (WHtR), kao i indeks telesne masnoće (BAI)] koji su zatim korelisani sa koncentracijama CRP u serumu. Rezultati. Prosečna vrednost nivoa CRP u serumu u celoj grupi iznosila je 5,56 ± 2,43 mg/L i utvrđena je njegova značajna pozitivna korelacija sa svim ispitivanim antropometrijskim parametrima. Uočena je statistički značajna razlika između grupa predgojaznih i gojaznih žena u svim ispitivanim antropometrijskim parametrima, kao i u pogledu koncentracije CRP. U grupi gojaznih ispitanica utvrđena je značajna povezanost između CRP i svih antropometrijskih parametara, dok u predgojaznoj grupi nije zabeležena statistička značajnost. U grupi gojaznih, svi antropometrijski pokazatelji pokazali su značajnu korelaciju sa procentom telesne masti, a kod predgojaznih žena, korelacija je bila značajna samo za telesnu masu, BMI, WC i WHtR. Zaključak. Između predgojaznih i gojaznih ispitanica postoji značajna razlika u pogledu svih pokazatelja centralne gojaznosti, kao i u pogledu koncentacije CRP u serumu. U grupi gojaznih, pokazana je značajna korelacija između sadržaja masti, izraženog kao procenat masnoće, i svih pokazatelja visceralne distribucije masti, dok u grupi predgojaznih značajna povezanost nije urađena za WHR i BAI. Naši rezultati potvrđuju da CRP može predstavljati značajan marker metaboličkog rizika kod gojaznih žena, kao i da je BMI, iako spada u tradicionalne parametre, i dalje pouzdan pokazatelj sadržaja telesne masti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "The relationship between adiposity parameters and C-reactive protein values in overweight and obese women, Odnos između parametara gojaznosti i vrednosti C-reaktivnog proteina kod predgojaznih i gojaznih žena",
volume = "75",
number = "2",
pages = "185-190",
doi = "10.2298/VSP160419208M"
}

Mraović, T., Radaković, S., Ristić-Medić, D., Dinčić, D., Tepšić-Ostojić, V., Čairović, A., Miljanović, G.,& Rađen, S.. (2018). The relationship between adiposity parameters and C-reactive protein values in overweight and obese women. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(2), 185-190.
https://doi.org/10.2298/VSP160419208M

Mraović T, Radaković S, Ristić-Medić D, Dinčić D, Tepšić-Ostojić V, Čairović A, Miljanović G, Rađen S. The relationship between adiposity parameters and C-reactive protein values in overweight and obese women. in Vojnosanitetski pregled. 2018;75(2):185-190.
doi:10.2298/VSP160419208M .

Mraović, Tatjana, Radaković, Sonja, Ristić-Medić, Danijela, Dinčić, Dragan, Tepšić-Ostojić, Vesna, Čairović, Aleksandra, Miljanović, Gora, Rađen, Slavica, "The relationship between adiposity parameters and C-reactive protein values in overweight and obese women" in Vojnosanitetski pregled, 75, no. 2 (2018):185-190,
https://doi.org/10.2298/VSP160419208M . .

TY  - JOUR
AU  - Stanković-Popović, Verica
AU  - Popović, Dragan
AU  - Dimković, Nada
AU  - Maksić, Đoko
AU  - Vasilijić, Saša
AU  - Čolić, Miodrag
AU  - Vučinić, Žarko
AU  - Rađen, Slavica
AU  - Miličić, Biljana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1774
AB  - Background/Aim. Morbidity and mortality of continous ambulatory peritoneal dialysis (CAPD) patients is still very high. The aim of the study was to evaluate the effects of peritoneal dialysis (PD) solutions (standard vs biocompatible) on long-term patients' and the techique survival. Methods. A total of 42 stable patients on CAPD participated in this crosssectional study. They were prospectively followed-up during the twelve years. Patients with severe anemia (Hb  lt  10 g/L) and malignant disease ware excluded. Twenty one (50%) patients were treated with the standard PD solutions (CAPDP- 1) while the other 21 (50%) were treated with biocompatible PD solutions [(lower level of glucose degradation products, lower concentration of Ca2+ and neutral pH (CAPDP-2)]. All patients were analyzed for a presence of vascular calcification, nutrition status, and parameters of inflammation after 2.5 ± 0.6 years of starting CAPD, and these variables considered in the analysis as risk factors. Results. The patients from the group CAPDP-2 compared to those from the group CAPDP-1 had lower level of high-sensitivity C-reactive protein (hs-CRP) (p = 0.003), and better nutritional status as confirmed by the mid-arm circumference (p = 0.015), and midarm muscle circumference (p = 0.002) and subjective global assessment (p = 0.000). Also, they had lower vascular calcifications as confirmed by intima media thickness (IMT) (p = 0.003), degree of carotid narrowing (p = 0.001) and calcified plaques of common carotid arteries (CCA) (p = 0.008). Kaplan- Meier analysis confirmed better survival of patients from the group CAPDP-2 than those from the group CAPDP-1 (1-, 5-, and 10-year patients survival rate was: 100%, 61.9% and 14.3% for the group CAPDP-1, and 100%, 85.7%, and 52.4% for the group CAPDP-2, respectively; p = 0.0345). The 1-, 5-, and 10-year technique survival rate was: 100%, 71.4%, and 38.1% for the group CAPDP-1, and 100%, 85.7%, and 76.2% for the group CAPDP-2, respectively; (p = 0.0719). Duration of dialysis, serum triglyceride and cardiovascular score (quantitative scoring system consisting of: ejection fraction (EF) of left ventricle  lt  50%; IMT > 1 mm; carotid narrowing degree > 50%, presence of carotid plaques in both common carotide, ischaemic heart disease, cerebrovascular event and peripheral vascular disease with or without amputation) were independent predictors of overall patient survival. Duration of dialysis was only independent predictor of overall technique survival. Conclusion. Although patients treated with biocompatible solutions showed significantly better survival, the role of biocompatibility of CAPD solutions in patients and technique survival have to be confirmed. Namely, multivariate analysis confirmed that duration of dialysis, serum triglyceride and cardiovascular score significantly predicted overall CAPD patients survival, while only duration of dialysis was found to be independent predictor of overall technique survival.
AB  - Uvod/Cilj. Morbiditet i mortalitet bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi (KAPD) i dalje je neprihvatljivo visok. Cilj rada bio je da se proceni uticaj vrste dijaliznih rasvora (bioinkompatibilni vs biokompatibilni) na višegodišnje preživljavanje bolesnika i same tehnike KAPD. Metode. Ovom studijom preseka sa delimično prospektivnim praćenjem ishoda lečenja obuhvaćeno je ukupno 42 nasumice izabrana, stabilna bolesnika (26 muškaraca i 16 žena) lečena primenom metode KAPD tokom poslednjih 12 godina. Isključeni su bolesnici sa teškom anemijom (Hb  lt 10 g/L) i malignom bolešću. Pri tome, 21 (50%) bolesnika kontinuirano je lečeno bioinkompatibilnim rastvorom za KAPD (kiseli standardni rastvor - ANDY-disc; grupa KAPDB-1), dok je preostalih 21 bolesnik sve vreme bilo na biokompatibilnijem rastvoru za KAPD (neutralni rastvor sa znatno manjom koncentracijom degradacionih produkata glukoze, 1.25 mmol/L Ca i 40 mmol/L laktata - Gambrosol Trio; grupa KAPDB-2). Svim bolesnicima određeni su odabrani parametri hronične inflamacije, malnutricije i ateroskleroze zajedno sa transportnim karakteristikama peritoneumske membrane i rezidualnom bubrežnom funkcijom nakon 2,5 ± 0,6 god od započinjanja KAPD. Svi dobijeni rezultati analizirani su kao potencijalni faktori rizika. Rezultati. Grupa KAPDB-2 u odnosu na KAPDB-1 imala je statistički značajno niže vrednosti serumskog hs-CRP (p = 0,003) i bolje parametre nutritivnog statusa izražene kroz obim nadlaktice (p = 0,015), obim mišića nadlaktice (p = 0,002) i subjektivnu globalnu procenu (p = 0,000) kao i u manjoj meri prisutnu aterosklerozu potvrđeno debljinom intimomedijalnog kompleksa (IMT) (p = 0,003), stepenom suženja karotida (p = 0,001) i prisustvom kalcifikovanih ateromatoznih plakova na karotidnim arterijama (p = 0,008). Kaplan-Meier-ova kriva preživljavanja potvrdila je značajno duže preživljavanje bolesnika u grupi KAPD-2 u odnosu na KAPDB-1 (1-, 5-, i 10-godišnje preživljavanje bolesnika iznosilo je redom: 100%, 61.9% i 14.3% u KAPDB-1, a 100%, 85,7% i 52,4% u KAPDB-2 grupi; p = 0,0345). Stopa 1-, 5-, i 10-godišnjeg preživljavanja metode iznosila je: 100%, 71,4% i 38,1% u KAPDB-1, a 100%, 85,7% i 76,2% u KAPDB-2 grupi (p = 0,0719). Kao nezavisni prediktori opšteg preživljavanja bolesnika na KAPD izdvojili su se: dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta (kvantitativni sistem zbrajanja prisutnih sledećih parametara: ejekciona frakcija (EF) leve komore  lt  50%; IMT >1 mm; suženje lumena karotida > 50%; kalcifikovani ateromatozni plakovi na obe karotide; ishemijska bolest srca; cerebrovaskularni događaj i periferna vaskularna bolest sa ili bez gangrene). Kao nezavisan prediktor preživljavanja metode izdvojio se jedino dijalizni staž. Zaključak. Iako su bolesnici na KAPD sa biokompatibilnijim rastvorima pokazali statistički značajno bolje preživljavanje, ne možemo tvrditi da bioinkompatibilnost dijaliznih rastvora predstavlja značajan faktor rizika od preživljavanja bolesnika i same metode lečenja. Naime, multivarijantnom analizom kao prediktori opšteg preživljavanja bolesnika izdvojili su se samo dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta, dok se za očuvanje peritoneumske membrane kao nezavisan faktor rizika prikazao samo dijalizni staž.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself
T1  - Uticaj biokompatibilnosti rastvora za peritoneumsku dijalizu na višegodišnje preživljavanje bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi i same metode lečenja
VL  - 70
IS  - 4
SP  - 352
EP  - 362
DO  - 10.2298/VSP1304352S
ER  - 

@article{
author = "Stanković-Popović, Verica and Popović, Dragan and Dimković, Nada and Maksić, Đoko and Vasilijić, Saša and Čolić, Miodrag and Vučinić, Žarko and Rađen, Slavica and Miličić, Biljana",
year = "2013",
abstract = "Background/Aim. Morbidity and mortality of continous ambulatory peritoneal dialysis (CAPD) patients is still very high. The aim of the study was to evaluate the effects of peritoneal dialysis (PD) solutions (standard vs biocompatible) on long-term patients' and the techique survival. Methods. A total of 42 stable patients on CAPD participated in this crosssectional study. They were prospectively followed-up during the twelve years. Patients with severe anemia (Hb  lt  10 g/L) and malignant disease ware excluded. Twenty one (50%) patients were treated with the standard PD solutions (CAPDP- 1) while the other 21 (50%) were treated with biocompatible PD solutions [(lower level of glucose degradation products, lower concentration of Ca2+ and neutral pH (CAPDP-2)]. All patients were analyzed for a presence of vascular calcification, nutrition status, and parameters of inflammation after 2.5 ± 0.6 years of starting CAPD, and these variables considered in the analysis as risk factors. Results. The patients from the group CAPDP-2 compared to those from the group CAPDP-1 had lower level of high-sensitivity C-reactive protein (hs-CRP) (p = 0.003), and better nutritional status as confirmed by the mid-arm circumference (p = 0.015), and midarm muscle circumference (p = 0.002) and subjective global assessment (p = 0.000). Also, they had lower vascular calcifications as confirmed by intima media thickness (IMT) (p = 0.003), degree of carotid narrowing (p = 0.001) and calcified plaques of common carotid arteries (CCA) (p = 0.008). Kaplan- Meier analysis confirmed better survival of patients from the group CAPDP-2 than those from the group CAPDP-1 (1-, 5-, and 10-year patients survival rate was: 100%, 61.9% and 14.3% for the group CAPDP-1, and 100%, 85.7%, and 52.4% for the group CAPDP-2, respectively; p = 0.0345). The 1-, 5-, and 10-year technique survival rate was: 100%, 71.4%, and 38.1% for the group CAPDP-1, and 100%, 85.7%, and 76.2% for the group CAPDP-2, respectively; (p = 0.0719). Duration of dialysis, serum triglyceride and cardiovascular score (quantitative scoring system consisting of: ejection fraction (EF) of left ventricle  lt  50%; IMT > 1 mm; carotid narrowing degree > 50%, presence of carotid plaques in both common carotide, ischaemic heart disease, cerebrovascular event and peripheral vascular disease with or without amputation) were independent predictors of overall patient survival. Duration of dialysis was only independent predictor of overall technique survival. Conclusion. Although patients treated with biocompatible solutions showed significantly better survival, the role of biocompatibility of CAPD solutions in patients and technique survival have to be confirmed. Namely, multivariate analysis confirmed that duration of dialysis, serum triglyceride and cardiovascular score significantly predicted overall CAPD patients survival, while only duration of dialysis was found to be independent predictor of overall technique survival., Uvod/Cilj. Morbiditet i mortalitet bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi (KAPD) i dalje je neprihvatljivo visok. Cilj rada bio je da se proceni uticaj vrste dijaliznih rasvora (bioinkompatibilni vs biokompatibilni) na višegodišnje preživljavanje bolesnika i same tehnike KAPD. Metode. Ovom studijom preseka sa delimično prospektivnim praćenjem ishoda lečenja obuhvaćeno je ukupno 42 nasumice izabrana, stabilna bolesnika (26 muškaraca i 16 žena) lečena primenom metode KAPD tokom poslednjih 12 godina. Isključeni su bolesnici sa teškom anemijom (Hb  lt 10 g/L) i malignom bolešću. Pri tome, 21 (50%) bolesnika kontinuirano je lečeno bioinkompatibilnim rastvorom za KAPD (kiseli standardni rastvor - ANDY-disc; grupa KAPDB-1), dok je preostalih 21 bolesnik sve vreme bilo na biokompatibilnijem rastvoru za KAPD (neutralni rastvor sa znatno manjom koncentracijom degradacionih produkata glukoze, 1.25 mmol/L Ca i 40 mmol/L laktata - Gambrosol Trio; grupa KAPDB-2). Svim bolesnicima određeni su odabrani parametri hronične inflamacije, malnutricije i ateroskleroze zajedno sa transportnim karakteristikama peritoneumske membrane i rezidualnom bubrežnom funkcijom nakon 2,5 ± 0,6 god od započinjanja KAPD. Svi dobijeni rezultati analizirani su kao potencijalni faktori rizika. Rezultati. Grupa KAPDB-2 u odnosu na KAPDB-1 imala je statistički značajno niže vrednosti serumskog hs-CRP (p = 0,003) i bolje parametre nutritivnog statusa izražene kroz obim nadlaktice (p = 0,015), obim mišića nadlaktice (p = 0,002) i subjektivnu globalnu procenu (p = 0,000) kao i u manjoj meri prisutnu aterosklerozu potvrđeno debljinom intimomedijalnog kompleksa (IMT) (p = 0,003), stepenom suženja karotida (p = 0,001) i prisustvom kalcifikovanih ateromatoznih plakova na karotidnim arterijama (p = 0,008). Kaplan-Meier-ova kriva preživljavanja potvrdila je značajno duže preživljavanje bolesnika u grupi KAPD-2 u odnosu na KAPDB-1 (1-, 5-, i 10-godišnje preživljavanje bolesnika iznosilo je redom: 100%, 61.9% i 14.3% u KAPDB-1, a 100%, 85,7% i 52,4% u KAPDB-2 grupi; p = 0,0345). Stopa 1-, 5-, i 10-godišnjeg preživljavanja metode iznosila je: 100%, 71,4% i 38,1% u KAPDB-1, a 100%, 85,7% i 76,2% u KAPDB-2 grupi (p = 0,0719). Kao nezavisni prediktori opšteg preživljavanja bolesnika na KAPD izdvojili su se: dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta (kvantitativni sistem zbrajanja prisutnih sledećih parametara: ejekciona frakcija (EF) leve komore  lt  50%; IMT >1 mm; suženje lumena karotida > 50%; kalcifikovani ateromatozni plakovi na obe karotide; ishemijska bolest srca; cerebrovaskularni događaj i periferna vaskularna bolest sa ili bez gangrene). Kao nezavisan prediktor preživljavanja metode izdvojio se jedino dijalizni staž. Zaključak. Iako su bolesnici na KAPD sa biokompatibilnijim rastvorima pokazali statistički značajno bolje preživljavanje, ne možemo tvrditi da bioinkompatibilnost dijaliznih rastvora predstavlja značajan faktor rizika od preživljavanja bolesnika i same metode lečenja. Naime, multivarijantnom analizom kao prediktori opšteg preživljavanja bolesnika izdvojili su se samo dijalizni staž, nivo serumskih triglicerida i skor kardiovaskularnog morbiditeta, dok se za očuvanje peritoneumske membrane kao nezavisan faktor rizika prikazao samo dijalizni staž.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself, Uticaj biokompatibilnosti rastvora za peritoneumsku dijalizu na višegodišnje preživljavanje bolesnika na kontinuiranoj ambulantnoj peritoneumskoj dijalizi i same metode lečenja",
volume = "70",
number = "4",
pages = "352-362",
doi = "10.2298/VSP1304352S"
}

Stanković-Popović, V., Popović, D., Dimković, N., Maksić, Đ., Vasilijić, S., Čolić, M., Vučinić, Ž., Rađen, S.,& Miličić, B.. (2013). Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 352-362.
https://doi.org/10.2298/VSP1304352S

Stanković-Popović V, Popović D, Dimković N, Maksić Đ, Vasilijić S, Čolić M, Vučinić Ž, Rađen S, Miličić B. Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself. in Vojnosanitetski pregled. 2013;70(4):352-362.
doi:10.2298/VSP1304352S .

Stanković-Popović, Verica, Popović, Dragan, Dimković, Nada, Maksić, Đoko, Vasilijić, Saša, Čolić, Miodrag, Vučinić, Žarko, Rađen, Slavica, Miličić, Biljana, "Influence of peritoneal dialysis solution biocompatibility on long-term survival of patients on continuous ambulatory peritoneal dialysis and the technique itself" in Vojnosanitetski pregled, 70, no. 4 (2013):352-362,
https://doi.org/10.2298/VSP1304352S . .

TY  - JOUR
AU  - Stanković-Popović, Verica
AU  - Nesić, V.
AU  - Popović, D.
AU  - Maksić, Đoko
AU  - Čolić, Miodrag
AU  - Vasilijić, Saša
AU  - Vučinić, Žarko
AU  - Miličić, Biljana
AU  - Rađen, Slavica
AU  - Dimković, Nada
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1614
AB  - Background: Chronic inflammation, malnutrition and atherosclerosis (MIA syndrome) are important predictors of high mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. We aimed to evaluate the effects of PD solutions (standard vs. biocompatible) on some parameters of MIA syndrome in patients undergoing CAPD. Methods: 42 stable patients who were on CAPD at least 2.5 years participated in this cross-sectional study. Patients who had severe anemia (Hb  lt  10 g/l), immunomodulatory therapy, peritonitis or any inflammatory conditions for at least 3 months before the analysis, malignant disease and acute exacerbation of heart failure, were excluded. 21 (50%) patients were treated with standard PD solutions (CAPDP-1), while the remaining 21(50% of patients) were treated with biocompatible PD solutions (neutral solutions with lower level of glucose degradation products and lower concentration of calcium, CAPDP-2). All patients underwent echocardiography and B-mode ultrasonography of common carotid arteries together with assessments of nutrition status and parameters of systemic and local inflammation. Results: There were no significant differences between the groups concerning age, gender, underlying disease, residual renal function, peritoneal transport characteristics, comorbidity or therapy applied. Patients from group CAPDP-2 had a significantly lower serum level of hs-CRP (3.7 +/- 2.6 mg/l vs. 6.3 +/- 4.5 mg/l; p = 0.023) and significantly better nutritional status confirmed by mid-arm circumference (p = 0.015), mid-arm muscle circumference (p = 0.002) and subjective global assessment (14.28% of patients in CAPDP-2 vs. 71% of patients in CAPDP-1 were malnourished; p = 0.000). Group CAPD-2 had less frequent left ventricular hypertrophy (p = 0.039), thinner intima-media thickness (p = 0.005), smaller carotid narrowing (p = 0.000) and fewer calcified plaques of common carotide arteries (p = 0.003). No significant difference between the CAPDP groups was observed in serum and effluent levels of inflammatory cytokines (IL-1, IL-6 and TNF-alpha) and CA-125 effluent level. Logistic regression analysis did not confirm that biocompatibility of PD solutions was an independent predictor of any parameter of MIA syndrome. Conclusions: According to the present study and logistic regression analysis, the effect of biocompatible CAPD solutions on parameters of malnutrition, inflammation and atherosclerosis have to be confirmed by well-designed and controlled studies in a higher number of patients.
PB  - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
T2  - Clinical Nephrology
T1  - Effects of conventional versus biocompatible peritoneal dialysis solutions on peritoneal and systemic inflammation, malnutrition and atherosclerosis in CAPD patients
VL  - 76
IS  - 4
SP  - 314
EP  - 322
DO  - 10.5414/CN106991
ER  - 

@article{
author = "Stanković-Popović, Verica and Nesić, V. and Popović, D. and Maksić, Đoko and Čolić, Miodrag and Vasilijić, Saša and Vučinić, Žarko and Miličić, Biljana and Rađen, Slavica and Dimković, Nada",
year = "2011",
abstract = "Background: Chronic inflammation, malnutrition and atherosclerosis (MIA syndrome) are important predictors of high mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. We aimed to evaluate the effects of PD solutions (standard vs. biocompatible) on some parameters of MIA syndrome in patients undergoing CAPD. Methods: 42 stable patients who were on CAPD at least 2.5 years participated in this cross-sectional study. Patients who had severe anemia (Hb  lt  10 g/l), immunomodulatory therapy, peritonitis or any inflammatory conditions for at least 3 months before the analysis, malignant disease and acute exacerbation of heart failure, were excluded. 21 (50%) patients were treated with standard PD solutions (CAPDP-1), while the remaining 21(50% of patients) were treated with biocompatible PD solutions (neutral solutions with lower level of glucose degradation products and lower concentration of calcium, CAPDP-2). All patients underwent echocardiography and B-mode ultrasonography of common carotid arteries together with assessments of nutrition status and parameters of systemic and local inflammation. Results: There were no significant differences between the groups concerning age, gender, underlying disease, residual renal function, peritoneal transport characteristics, comorbidity or therapy applied. Patients from group CAPDP-2 had a significantly lower serum level of hs-CRP (3.7 +/- 2.6 mg/l vs. 6.3 +/- 4.5 mg/l; p = 0.023) and significantly better nutritional status confirmed by mid-arm circumference (p = 0.015), mid-arm muscle circumference (p = 0.002) and subjective global assessment (14.28% of patients in CAPDP-2 vs. 71% of patients in CAPDP-1 were malnourished; p = 0.000). Group CAPD-2 had less frequent left ventricular hypertrophy (p = 0.039), thinner intima-media thickness (p = 0.005), smaller carotid narrowing (p = 0.000) and fewer calcified plaques of common carotide arteries (p = 0.003). No significant difference between the CAPDP groups was observed in serum and effluent levels of inflammatory cytokines (IL-1, IL-6 and TNF-alpha) and CA-125 effluent level. Logistic regression analysis did not confirm that biocompatibility of PD solutions was an independent predictor of any parameter of MIA syndrome. Conclusions: According to the present study and logistic regression analysis, the effect of biocompatible CAPD solutions on parameters of malnutrition, inflammation and atherosclerosis have to be confirmed by well-designed and controlled studies in a higher number of patients.",
publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen",
journal = "Clinical Nephrology",
title = "Effects of conventional versus biocompatible peritoneal dialysis solutions on peritoneal and systemic inflammation, malnutrition and atherosclerosis in CAPD patients",
volume = "76",
number = "4",
pages = "314-322",
doi = "10.5414/CN106991"
}

Stanković-Popović, V., Nesić, V., Popović, D., Maksić, Đ., Čolić, M., Vasilijić, S., Vučinić, Ž., Miličić, B., Rađen, S.,& Dimković, N.. (2011). Effects of conventional versus biocompatible peritoneal dialysis solutions on peritoneal and systemic inflammation, malnutrition and atherosclerosis in CAPD patients. in Clinical Nephrology
Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 76(4), 314-322.
https://doi.org/10.5414/CN106991

Stanković-Popović V, Nesić V, Popović D, Maksić Đ, Čolić M, Vasilijić S, Vučinić Ž, Miličić B, Rađen S, Dimković N. Effects of conventional versus biocompatible peritoneal dialysis solutions on peritoneal and systemic inflammation, malnutrition and atherosclerosis in CAPD patients. in Clinical Nephrology. 2011;76(4):314-322.
doi:10.5414/CN106991 .

Stanković-Popović, Verica, Nesić, V., Popović, D., Maksić, Đoko, Čolić, Miodrag, Vasilijić, Saša, Vučinić, Žarko, Miličić, Biljana, Rađen, Slavica, Dimković, Nada, "Effects of conventional versus biocompatible peritoneal dialysis solutions on peritoneal and systemic inflammation, malnutrition and atherosclerosis in CAPD patients" in Clinical Nephrology, 76, no. 4 (2011):314-322,
https://doi.org/10.5414/CN106991 . .