TY  - JOUR
AU  - Petrović-Matić, Sanja
AU  - Zelić, Ksenija
AU  - Milašin, Jelena
AU  - Popović, Branka
AU  - Pucar, Ana
AU  - Zelić, Obrad
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1917
AB  - Introduction Pathogenesis and some characteristics of periodontitis cannot be fully explained by bacterial etiology alone. Herpes viruses may bridge the gap between clinical characteristics and molecular understanding of periodontal destruction. Objective The aim of this study was to investigate the prevalence of herpes simplex virus type 1 (HSV-1) in gingival crevicular fluid (GCF) of healthy and damaged periodontium in Serbian population and to explore potential correlation between the presence of this virus and the level of periodontal destruction. Methods Samples were collected from gingival sulcus/periodontal pockets by sterile paper points and the presence of viral DNA in gingival crevicular fluid was assessed by PCR. Results There was no statistically significant difference in HSV-1 in presence between periodontitis patients (PG=38.9%) and healthy controls (HC=32.3%), (Chi-square test, with Yates' correction p=0.7574). However, HSV-1 positive patients showed significantly higher values of parameters of periodontal destruction (PPD=7.11±2.52, CAL=5.46±2.34) than periodontitis patients without HSV-1 in gingival crevicular fluid (PPD=4.70±1.79, CAL=3.39±2.65) (p values respectively, p=0.002 and p=0.023, Independent Samples T-Test). HSV-1 occurred more often in deeper (PPD≥6 mm) (69.2%) than in shallow pockets (3 mm lt PPD lt 6 mm) (18.2%) (Chi-square test, with Yates' correction, p=0.008). Plaque index was lower in the HSV-1 positive group (0.84± 0.69 vs. 1.43±0.76, p=0.023, Independent Samples T-Test). Conclusion This study demonstrated that the presence of HSV-1 in the gingival crevicular fluid coincides with a higher degree of tissue destruction in patients with periodontitis.
AB  - Uvod Patogeneza i neke kliničke odlike parodontopatije ne mogu se do kraja objasniti bakterijskom etiologijom. Herpesvirusi bi mogli da premoste jaz koji postoji između kliničkih osobina i poznavanja patogenetskih mehanizama parodontopatije na molekularnom nivou. Cilj rada Cilj ove studije bio je određivanje prevalencije virusa herpes simplex tip 1 (HSV-1) u zdravom i obolelom parodoncijumu osoba u Srbiji, kao i utvrđivanje moguće korelacije između postojanja ovih virusa i stepena oštećenja parodoncijuma. Metode rada Uzorci su uzimani papirnim poenima iz gingivalnih sulkusa ili parodontalnih džepova, a virus je otkrivan reakcijom lančanog umnožavanja molekula DNK (engl. polymerase chain reaction - PCR). Rezultati Nije utvrđena statistički značajna razlika u prevalenciji HSV-1 između osoba s parodontopatijom (32,3%) i zdravim parodoncijumom (38,9%); χ2-test sa Jejtsovom (Yates) korekcijom: p=0,7574. U grupi ispitanika s parodontopatijom parametri koji označavaju stepen oštećenja (dubina parodontalnog džepa - DPDž; nivo pripojnog epitela - NPE) bili su značajno veći kod onih s otkrivenim virusom (DPDž: 7,11±2,52 mm; NPE: 5,46±2,34), nego kod ispitanika bez virusa u uzorcima gingivalne tečnosti (DPDž=4,70±1,79 mm; NPE=3,39±2,65); Studentov t-test za nevezane uzorke: p=0,002, odnosno p=0,023. U dubljim parodontalnim džepovima (DPDž≥6 mm) HSV-1 je otkriven statistički značajno češće (69,2%) nego u plićim džepovima (DPDž=3-6 mm) (18,2%); χ2-test sa Jejtsovom korekcijom: p=0,008. Prosečne vrednosti plak-indeksa bile su niže kod ispitanika sa HSV-1 (0,84±0,69) u poređenju sa ispitanicima kod kojih ovaj virus nije otkriven (1,43±0,76); Studentov t-test za nevezane uzorke: p=0,023. Zaključak Prikazana studija pokazala je da je postojanje HSV-1 povezano sa nivoom oštećenja tkiva kod osoba s parodontopatijom.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Detection of herpes simplex virus type 1 in gingival crevicular fluid of gingival sulcus/periodontal pocket using polymerase chain reaction
T1  - Otkrivanje virusa herpes simplex tip 1 u gingivalnoj tečnosti sulkusa ili parodontalnog džepa lančanom reakcijom polimeraze
VL  - 142
IS  - 5-6
SP  - 296
EP  - 300
DO  - 10.2298/SARH1406296M
ER  - 

@article{
author = "Petrović-Matić, Sanja and Zelić, Ksenija and Milašin, Jelena and Popović, Branka and Pucar, Ana and Zelić, Obrad",
year = "2014",
abstract = "Introduction Pathogenesis and some characteristics of periodontitis cannot be fully explained by bacterial etiology alone. Herpes viruses may bridge the gap between clinical characteristics and molecular understanding of periodontal destruction. Objective The aim of this study was to investigate the prevalence of herpes simplex virus type 1 (HSV-1) in gingival crevicular fluid (GCF) of healthy and damaged periodontium in Serbian population and to explore potential correlation between the presence of this virus and the level of periodontal destruction. Methods Samples were collected from gingival sulcus/periodontal pockets by sterile paper points and the presence of viral DNA in gingival crevicular fluid was assessed by PCR. Results There was no statistically significant difference in HSV-1 in presence between periodontitis patients (PG=38.9%) and healthy controls (HC=32.3%), (Chi-square test, with Yates' correction p=0.7574). However, HSV-1 positive patients showed significantly higher values of parameters of periodontal destruction (PPD=7.11±2.52, CAL=5.46±2.34) than periodontitis patients without HSV-1 in gingival crevicular fluid (PPD=4.70±1.79, CAL=3.39±2.65) (p values respectively, p=0.002 and p=0.023, Independent Samples T-Test). HSV-1 occurred more often in deeper (PPD≥6 mm) (69.2%) than in shallow pockets (3 mm lt PPD lt 6 mm) (18.2%) (Chi-square test, with Yates' correction, p=0.008). Plaque index was lower in the HSV-1 positive group (0.84± 0.69 vs. 1.43±0.76, p=0.023, Independent Samples T-Test). Conclusion This study demonstrated that the presence of HSV-1 in the gingival crevicular fluid coincides with a higher degree of tissue destruction in patients with periodontitis., Uvod Patogeneza i neke kliničke odlike parodontopatije ne mogu se do kraja objasniti bakterijskom etiologijom. Herpesvirusi bi mogli da premoste jaz koji postoji između kliničkih osobina i poznavanja patogenetskih mehanizama parodontopatije na molekularnom nivou. Cilj rada Cilj ove studije bio je određivanje prevalencije virusa herpes simplex tip 1 (HSV-1) u zdravom i obolelom parodoncijumu osoba u Srbiji, kao i utvrđivanje moguće korelacije između postojanja ovih virusa i stepena oštećenja parodoncijuma. Metode rada Uzorci su uzimani papirnim poenima iz gingivalnih sulkusa ili parodontalnih džepova, a virus je otkrivan reakcijom lančanog umnožavanja molekula DNK (engl. polymerase chain reaction - PCR). Rezultati Nije utvrđena statistički značajna razlika u prevalenciji HSV-1 između osoba s parodontopatijom (32,3%) i zdravim parodoncijumom (38,9%); χ2-test sa Jejtsovom (Yates) korekcijom: p=0,7574. U grupi ispitanika s parodontopatijom parametri koji označavaju stepen oštećenja (dubina parodontalnog džepa - DPDž; nivo pripojnog epitela - NPE) bili su značajno veći kod onih s otkrivenim virusom (DPDž: 7,11±2,52 mm; NPE: 5,46±2,34), nego kod ispitanika bez virusa u uzorcima gingivalne tečnosti (DPDž=4,70±1,79 mm; NPE=3,39±2,65); Studentov t-test za nevezane uzorke: p=0,002, odnosno p=0,023. U dubljim parodontalnim džepovima (DPDž≥6 mm) HSV-1 je otkriven statistički značajno češće (69,2%) nego u plićim džepovima (DPDž=3-6 mm) (18,2%); χ2-test sa Jejtsovom korekcijom: p=0,008. Prosečne vrednosti plak-indeksa bile su niže kod ispitanika sa HSV-1 (0,84±0,69) u poređenju sa ispitanicima kod kojih ovaj virus nije otkriven (1,43±0,76); Studentov t-test za nevezane uzorke: p=0,023. Zaključak Prikazana studija pokazala je da je postojanje HSV-1 povezano sa nivoom oštećenja tkiva kod osoba s parodontopatijom.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Detection of herpes simplex virus type 1 in gingival crevicular fluid of gingival sulcus/periodontal pocket using polymerase chain reaction, Otkrivanje virusa herpes simplex tip 1 u gingivalnoj tečnosti sulkusa ili parodontalnog džepa lančanom reakcijom polimeraze",
volume = "142",
number = "5-6",
pages = "296-300",
doi = "10.2298/SARH1406296M"
}

Petrović-Matić, S., Zelić, K., Milašin, J., Popović, B., Pucar, A.,& Zelić, O.. (2014). Detection of herpes simplex virus type 1 in gingival crevicular fluid of gingival sulcus/periodontal pocket using polymerase chain reaction. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(5-6), 296-300.
https://doi.org/10.2298/SARH1406296M

Petrović-Matić S, Zelić K, Milašin J, Popović B, Pucar A, Zelić O. Detection of herpes simplex virus type 1 in gingival crevicular fluid of gingival sulcus/periodontal pocket using polymerase chain reaction. in Srpski arhiv za celokupno lekarstvo. 2014;142(5-6):296-300.
doi:10.2298/SARH1406296M .

Petrović-Matić, Sanja, Zelić, Ksenija, Milašin, Jelena, Popović, Branka, Pucar, Ana, Zelić, Obrad, "Detection of herpes simplex virus type 1 in gingival crevicular fluid of gingival sulcus/periodontal pocket using polymerase chain reaction" in Srpski arhiv za celokupno lekarstvo, 142, no. 5-6 (2014):296-300,
https://doi.org/10.2298/SARH1406296M . .

TY  - JOUR
AU  - Brković-Popović, Snežana
AU  - Ašanin, R.
AU  - Poštić, Srđan
AU  - Stamenković, D.
AU  - Zelić, Obrad
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1535
AB  - From the very beginning of life, living organisms were exposed to the influence of geoelectric and geomagnetic fields, with established balance with this respect. Development of civilization has been distorted balance and harmony, imposing the extreme need for magnetism. Respecting positive effects of magnetic field to tissues, especially 'bactericide' effect, this investigation was conducted on the aim to assess the influence of magnetic field to oral microbes. Materials and method. This investigation was carried to in vitro. To obtain adequate samples of deposits or specimens of dental plaque, were from certain microbes which were isolated from human mouth. Microbes isolated from samples were Streptococcus parasanguis, Staphylococcus epidermidis, Rodococcus equi and Candida albicans. Turbidimetry array was applied for investigation of this kind. The method of spectrophotometry was applied, to obtain optical den­sity (OD) value and to establish indirectly a growth of intensity of sowed microbe's stains on the basis of modified OD of agar. Investigation was carried on two level of density of microbes of 1 CFU/ml as well as of 10 CFU/ml after 24h period and 48h period of incubation of microbes. Results. Positive effect of magnetic field upon dental plaque of bacteria reduction in vitro was recognized. At the baseline-initial 24 hours period of measurement of exposition to magnetic field, the count of all isolated mi­crobes has been significantly reduced, in the both of agar of increased density as well as of agar with reduced OD. Over the time, the decrement of influence of magnets versus microbes in vitro has been detected. Conclusion. Count of this influence of the magnet to microbes is of extreme importance in parodontology. This way, the positive influence of magnet to supporting tissues and quality and durability of overdenture was confirmed. .
AB  - Sva živa bića su izložena dejstvu geoelektričnog i geomagnetskog polja i u tom smislu je ostvarena ravnoteža. Sa razvojem civilizacije ta ravnoteža se narušava u smislu da slabi uticaj geomagnetnog polja i postoji t.z.v. 'glad' za magnetizmom. Imajući u vidu pozitivan uticaj magneta na sva biološka tkiva, posebno 'baktericidni' efekat israživanje je sprovedeno sa ciljem da se ispita uticaj magnetnog polja na oralnu mikrofloru. Materijal i metod: Istraživanja su sprovedena in vitro. Uzorci, tj. brisevi zubnih naslaga poticali su sa zuba pacijenata Stomatološkog fakulteta u Beogradu. Iz uzoraka su izolovani: Streptococcus parasanguis, Staphylococcus epidermidis, Rodococcus equi i Candida albicans. Korišćena je metoda turbidimetrija gde se spektrofotometrom na osnovu optičke gustine bujona indirektno utvrđuje intenzitet rasta zasejanih mikro-organizama. Ispitivanje je vršeno sa 2 gustine mikroorganizama 1 i 10 CFU/ml i to nakon 24 i 48 h inkubacije mikroorganizama. Rezultati pokazuju da je došlo do redukcije broja bakterija u in vitro uslovima. U prvih 24 h izloženosti uticaju magnetnog polja ta redukcija je bila značajna kako u bujonima veće tako i manje gustine. Tokom vremena uticaj magneta na brojnost mikroflore u in vitro uslovima opada. Zaključak Ovakav uticaj magneta na brojnost mikroorganizama je značajan u parodontologiji pa samim tim ima pozitivan uticaj na potporna tkiva ispod supraden-talnih proteza, na njihov kvalitet i trajnost. .
PB  - Antropološko društvo Srbije, Niš i Univerzitet u Nišu - Prirodno-matematički fakultet, Niš
T2  - Glasnik Antropološkog društva Srbije
T1  - Influence of magnetic field to microbes in oral environment
T1  - Uticaj magnetnog polja na oralnu mikrofloru
IS  - 45
SP  - 511
EP  - 519
UR  - https://hdl.handle.net/21.15107/rcub_smile_1535
ER  - 

@article{
author = "Brković-Popović, Snežana and Ašanin, R. and Poštić, Srđan and Stamenković, D. and Zelić, Obrad",
year = "2010",
abstract = "From the very beginning of life, living organisms were exposed to the influence of geoelectric and geomagnetic fields, with established balance with this respect. Development of civilization has been distorted balance and harmony, imposing the extreme need for magnetism. Respecting positive effects of magnetic field to tissues, especially 'bactericide' effect, this investigation was conducted on the aim to assess the influence of magnetic field to oral microbes. Materials and method. This investigation was carried to in vitro. To obtain adequate samples of deposits or specimens of dental plaque, were from certain microbes which were isolated from human mouth. Microbes isolated from samples were Streptococcus parasanguis, Staphylococcus epidermidis, Rodococcus equi and Candida albicans. Turbidimetry array was applied for investigation of this kind. The method of spectrophotometry was applied, to obtain optical den­sity (OD) value and to establish indirectly a growth of intensity of sowed microbe's stains on the basis of modified OD of agar. Investigation was carried on two level of density of microbes of 1 CFU/ml as well as of 10 CFU/ml after 24h period and 48h period of incubation of microbes. Results. Positive effect of magnetic field upon dental plaque of bacteria reduction in vitro was recognized. At the baseline-initial 24 hours period of measurement of exposition to magnetic field, the count of all isolated mi­crobes has been significantly reduced, in the both of agar of increased density as well as of agar with reduced OD. Over the time, the decrement of influence of magnets versus microbes in vitro has been detected. Conclusion. Count of this influence of the magnet to microbes is of extreme importance in parodontology. This way, the positive influence of magnet to supporting tissues and quality and durability of overdenture was confirmed. ., Sva živa bića su izložena dejstvu geoelektričnog i geomagnetskog polja i u tom smislu je ostvarena ravnoteža. Sa razvojem civilizacije ta ravnoteža se narušava u smislu da slabi uticaj geomagnetnog polja i postoji t.z.v. 'glad' za magnetizmom. Imajući u vidu pozitivan uticaj magneta na sva biološka tkiva, posebno 'baktericidni' efekat israživanje je sprovedeno sa ciljem da se ispita uticaj magnetnog polja na oralnu mikrofloru. Materijal i metod: Istraživanja su sprovedena in vitro. Uzorci, tj. brisevi zubnih naslaga poticali su sa zuba pacijenata Stomatološkog fakulteta u Beogradu. Iz uzoraka su izolovani: Streptococcus parasanguis, Staphylococcus epidermidis, Rodococcus equi i Candida albicans. Korišćena je metoda turbidimetrija gde se spektrofotometrom na osnovu optičke gustine bujona indirektno utvrđuje intenzitet rasta zasejanih mikro-organizama. Ispitivanje je vršeno sa 2 gustine mikroorganizama 1 i 10 CFU/ml i to nakon 24 i 48 h inkubacije mikroorganizama. Rezultati pokazuju da je došlo do redukcije broja bakterija u in vitro uslovima. U prvih 24 h izloženosti uticaju magnetnog polja ta redukcija je bila značajna kako u bujonima veće tako i manje gustine. Tokom vremena uticaj magneta na brojnost mikroflore u in vitro uslovima opada. Zaključak Ovakav uticaj magneta na brojnost mikroorganizama je značajan u parodontologiji pa samim tim ima pozitivan uticaj na potporna tkiva ispod supraden-talnih proteza, na njihov kvalitet i trajnost. .",
publisher = "Antropološko društvo Srbije, Niš i Univerzitet u Nišu - Prirodno-matematički fakultet, Niš",
journal = "Glasnik Antropološkog društva Srbije",
title = "Influence of magnetic field to microbes in oral environment, Uticaj magnetnog polja na oralnu mikrofloru",
number = "45",
pages = "511-519",
url = "https://hdl.handle.net/21.15107/rcub_smile_1535"
}

Brković-Popović, S., Ašanin, R., Poštić, S., Stamenković, D.,& Zelić, O.. (2010). Influence of magnetic field to microbes in oral environment. in Glasnik Antropološkog društva Srbije
Antropološko društvo Srbije, Niš i Univerzitet u Nišu - Prirodno-matematički fakultet, Niš.(45), 511-519.
https://hdl.handle.net/21.15107/rcub_smile_1535

Brković-Popović S, Ašanin R, Poštić S, Stamenković D, Zelić O. Influence of magnetic field to microbes in oral environment. in Glasnik Antropološkog društva Srbije. 2010;(45):511-519.
https://hdl.handle.net/21.15107/rcub_smile_1535 .

Brković-Popović, Snežana, Ašanin, R., Poštić, Srđan, Stamenković, D., Zelić, Obrad, "Influence of magnetic field to microbes in oral environment" in Glasnik Antropološkog društva Srbije, no. 45 (2010):511-519,
https://hdl.handle.net/21.15107/rcub_smile_1535 .

TY  - JOUR
AU  - Luković, Natalija
AU  - Zelić, Obrad
AU  - Čakić, Saša
AU  - Petrović, Vanja
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1461
AB  - Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery and 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance.
AB  - Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects
T1  - Primena beta trikalcijum-fosfata i goveđeg koštanog matriksa u vođenoj regeneraciji dubokih infrakoštanih parodontalnih oštećenja
VL  - 137
IS  - 11-12
SP  - 607
EP  - 612
DO  - 10.2298/SARH0912607L
ER  - 

@article{
author = "Luković, Natalija and Zelić, Obrad and Čakić, Saša and Petrović, Vanja",
year = "2009",
abstract = "Introduction. The primary goal of bone regeneration procedures with application of various regenerative biologic agents and biomaterials is to facilitate the formation of periodontal tissues lost as a result of periodontitis. Objective. The aim of the study was to compare clinical outcome of the guided tissue regeneration (GTR) treatment with the use of β-tricalcium phosphate and with bovine bone matrix in human deep intra-osseous defects. Methods. Twenty-one systemically healthy subjects with moderate to advanced periodontitis, between 30 and 56 years of age, 11 females and 10 males, were selected. Patients having two similar inter-proximal defects with pocket probing depths following initial therapy greater than 5 mm were recruited for the study. Experimental sites were grafted with pure β-tricalcium phosphate biomaterial (Cerasorb®) and a biomembrane, while control sites were treated with bovine-bone hydroxiapatite xenograft (Bio-oss®) and a biomembrane. Immediately before surgery and 12 months after surgery, pocket probing depth (PPD), epithelial attachment level (EAL) and gingival recession (GR) were evaluated. Results. In the experimental group PPD amounted to 6.76±0.83 mm before surgery, and decreased significantly to 2.67±0.48 mm 12 months following surgery, while in the control group PPD significantly decreased from 7.14±0.65 mm presurgically to 2.85±0.57 mm postsurgically. After one year, EAL gain was 2.76±0.99 mm in the experimental group, and 3.24±0.16 mm in the control group. After twelve months postoperatively GR amounted to 1.33±0.79 mm in the experimental group and to 1.05±0.80 mm in the control group. No statistically significant differences for PPD reduction, EAL gain and GR increase were detected between the groups. Conclusion. Results from the present study indicate that GTR treatment of deep intra-osseous defects with Bio-oss® and Cerasorb® resulted in clinically and statistically significant improvement of EAL gain and PPD reduction. A GR was slightly increased, with no statistical significance., Uvod. Za regeneraciju tkiva koje je izgubljeno tokom parodontopatije koriste se razni biološki i sintetski materijali s različitim uspehom. Oni se najčešće primenjuju za obnavljanje pripojnog epitela i gubljenje alveolarne kosti u dubokim infrakoštanim oštećenjima. Cilj rada. Cilj rada je bio da se ispita značaj primene beta trikalcijum-fosfata i hidroksiapatita u lečenju dubokih infrakoštanih oštećenja. Metode rada. U istraživanje je uključena dvadeset i jedna zdrava osoba (11 žena i 10 muškaraca) starosti 30-45 godina kod koje je dijagnostikovana parodontopatija. Kod svih ispitanika ustanovljena su dva slična oštećenja sa dubinom sondiranja džepa od preko 5 mm. Tzv. eksperimentalna strana je tretirana čistim beta trikalcijum-fosfatnim biomaterijalom (Cerasorb®) i biomembranom, dok je tzv. kontrolna strana tretirana hidroksiapatitnim goveđim koštanim ksenograftom (Bio-oss®) i biomembranom. Dubina sondiranja džepa, nivo pripojenog epitela i recesija gingive su zabeleženi neposredno pre intervencije i 12 meseci kasnije. Rezultati. U eksperimentalnoj grupi dubina sondiranja džepa je bila 6,76±0,83 mm pre intervencije, a značajno manja nakon 12 meseci (2,76±0,48 mm). U kontrolnoj grupi ona je bila 7,14±0,65 mm pre intervencije, a značajno manja na kontrolnom pregledu (2,85±0,57 mm). Posle godinu dana nivo pripojenog epitela se povećao 2,76±0,99 mm u eksperimentalnoj grupi, odnosno 3,24±0,16 mm u kontrolnoj. Dvanaest meseci nakon intervencije recesija gingive bila je 1,33±0,79 mm u eksperimentalnoj, odnosno 1,05±0,80 mm u kontrolnoj grupi. Nisu zabeležene statistički značajne razlike u vrednosti dubine sondiranja džepa, nivou pripojenog epitela i recesiji gingive između kontrolne i eksperimentalne grupe. Zaključak. Tretman dubokih infrakoštanih oštećenja beta trikalcijum-fosfatom i hidroksiapatitom dao je dobre kliničke rezultate, budući da se značajno smanjila dubina oštećenja, a nivo pripojenog epitela podigao. Recesija gingive se umanjila, ali bez statistički značajne razlike.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects, Primena beta trikalcijum-fosfata i goveđeg koštanog matriksa u vođenoj regeneraciji dubokih infrakoštanih parodontalnih oštećenja",
volume = "137",
number = "11-12",
pages = "607-612",
doi = "10.2298/SARH0912607L"
}

Luković, N., Zelić, O., Čakić, S.,& Petrović, V.. (2009). The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(11-12), 607-612.
https://doi.org/10.2298/SARH0912607L

Luković N, Zelić O, Čakić S, Petrović V. The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects. in Srpski arhiv za celokupno lekarstvo. 2009;137(11-12):607-612.
doi:10.2298/SARH0912607L .

Luković, Natalija, Zelić, Obrad, Čakić, Saša, Petrović, Vanja, "The use of beta-tricalcium phosphate and bovine bone matrix in the guided tissue regeneration treatment of deep infra-bony defects" in Srpski arhiv za celokupno lekarstvo, 137, no. 11-12 (2009):607-612,
https://doi.org/10.2298/SARH0912607L . .

TY  - JOUR
AU  - Zelić, Obrad
AU  - Čakić, Saša
AU  - Luković, Natalija
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1506
AB  - Introduction. Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept® solution. Objective. This study evaluated the effect of Ozosept® solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP® solution (chlorhexidine digluconate). Methods. Two groups, each of 21 persons, which did not significantly differ concerning Silness-Löe plaque index (PI) and Löe-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period. Results. At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP® group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept® solution. Conclusion. It is concluded that Ozosept® solution is effective in the control of dental plaque - biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage.
AB  - Uvod. Oralni antiseptici su predmet mnogih istraživanja veoma dugo - od trenutka kada je otkriveno da su oboljenja potpornog aparata zuba bakterijskog porekla. Malo je, međutim, originalnih domaćih preparata s antiseptičkim dejstvom za ispiranje usne duplje. Cilj rada. Cilj rada je bio da se ispita efekat rastvora Ozosept® (fenolna jedinjenja) na oralnu higijenu i zapaljenje gingive, te uporedi s učinkom rastvora Hibidex DAP® (hlorheksidin-diglukonat). Metode rada. U istraživanje su uključene dve grupe od po 21 ispitanika koje su u pogledu Silnes-Loevog (Silness-Löe) plak-indeksa (PI) i Loe-Silnesovog (Löe-Silness) gingivnog indeksa (GI) predstavljale statistički homogenu grupu, odnosno koje su na početku eksperimentalnog perioda koristile jedan od navedenih oralnih antiseptika tokom 15 dana. Tokom eksperimentalnog perioda ispitanici su održavali oralnu higijenu na dotada uobičajeni način i nije primenjivana nijedna metoda profesionalnog čišćenja zuba. Rezultati. U obe grupe ispitanika vrednosti PI i GI su na kraju eksperimenta bile smanjene sa statistički visokom značajnošću u odnosu na vrednosti na početku ispitivanja. Vrednosti PI i GI na kraju eksperimenta se nisu značajno razlikovale između posmatranih grupa. Takođe, kod ispitanika koji su primenjivali rastvor Ozosept® nije uočen nijedan neželjeni efekat, dok je u grupi koja je primenjivala rastvor Hibidex DAP® prebojenost zuba uočena kod 9,5% ispitanika, prebojenost plombi kod 4,75%, prolazna utrnulost jezika kod 28,6%, a smanjenje percepcije ukusa kod 14,3% ispitanika. Zaključak. Rastvor Ozosept® je efikasno sredstvo u kontroli akumulacije dentalnog plaka (biofilma) i zapaljenja gingive i ne stvara neželjene efekte.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation
T1  - Uticaj dva različita oralna antiseptika na akumulaciju dentalnog plaka (biofilma) i zapaljenje gingive
VL  - 137
IS  - 1-2
SP  - 6
EP  - 9
DO  - 10.2298/SARH0902006Z
ER  - 

@article{
author = "Zelić, Obrad and Čakić, Saša and Luković, Natalija",
year = "2009",
abstract = "Introduction. Since the discovery that periodontal diseases are caused by microbial plaque the interest of many scientists has been focused on oral antiseptics. There are very few mouthrinses with oral antiseptic effect originally designed in our country. One of these is Ozosept® solution. Objective. This study evaluated the effect of Ozosept® solution (phenol compound) on the oral hygiene and gingival inflammation, in comparison with Hibidex DAP® solution (chlorhexidine digluconate). Methods. Two groups, each of 21 persons, which did not significantly differ concerning Silness-Löe plaque index (PI) and Löe-Sillnes gingival index (GI), used one of the studied oral antiseptic for a 15-day period. Oral hygiene was maintained by subjects' habitual home methods, and no technique of professionally advised brushing was performed during the experimental period. Results. At the end of the study, PI and GI scores were lowered to a statistically high significance in both groups of participants in comparison to the indexes at the beginning of the study. At the end of the study, PI and GI scores did not significantly differ between the two analyzed groups. No side effects, which were recorded in the Hibidex DAP® group (tooth and filling staining 9.5% and 4.74% respectively, transitory tongue numbness 28.6% and reduced taste sensation 14.3%), were registered in the group of subjects using Ozosept® solution. Conclusion. It is concluded that Ozosept® solution is effective in the control of dental plaque - biofilm accumulation and gingival inflammation, and produces no side effects related to chlorhexidine digluconate usage., Uvod. Oralni antiseptici su predmet mnogih istraživanja veoma dugo - od trenutka kada je otkriveno da su oboljenja potpornog aparata zuba bakterijskog porekla. Malo je, međutim, originalnih domaćih preparata s antiseptičkim dejstvom za ispiranje usne duplje. Cilj rada. Cilj rada je bio da se ispita efekat rastvora Ozosept® (fenolna jedinjenja) na oralnu higijenu i zapaljenje gingive, te uporedi s učinkom rastvora Hibidex DAP® (hlorheksidin-diglukonat). Metode rada. U istraživanje su uključene dve grupe od po 21 ispitanika koje su u pogledu Silnes-Loevog (Silness-Löe) plak-indeksa (PI) i Loe-Silnesovog (Löe-Silness) gingivnog indeksa (GI) predstavljale statistički homogenu grupu, odnosno koje su na početku eksperimentalnog perioda koristile jedan od navedenih oralnih antiseptika tokom 15 dana. Tokom eksperimentalnog perioda ispitanici su održavali oralnu higijenu na dotada uobičajeni način i nije primenjivana nijedna metoda profesionalnog čišćenja zuba. Rezultati. U obe grupe ispitanika vrednosti PI i GI su na kraju eksperimenta bile smanjene sa statistički visokom značajnošću u odnosu na vrednosti na početku ispitivanja. Vrednosti PI i GI na kraju eksperimenta se nisu značajno razlikovale između posmatranih grupa. Takođe, kod ispitanika koji su primenjivali rastvor Ozosept® nije uočen nijedan neželjeni efekat, dok je u grupi koja je primenjivala rastvor Hibidex DAP® prebojenost zuba uočena kod 9,5% ispitanika, prebojenost plombi kod 4,75%, prolazna utrnulost jezika kod 28,6%, a smanjenje percepcije ukusa kod 14,3% ispitanika. Zaključak. Rastvor Ozosept® je efikasno sredstvo u kontroli akumulacije dentalnog plaka (biofilma) i zapaljenja gingive i ne stvara neželjene efekte.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation, Uticaj dva različita oralna antiseptika na akumulaciju dentalnog plaka (biofilma) i zapaljenje gingive",
volume = "137",
number = "1-2",
pages = "6-9",
doi = "10.2298/SARH0902006Z"
}

Zelić, O., Čakić, S.,& Luković, N.. (2009). The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 137(1-2), 6-9.
https://doi.org/10.2298/SARH0902006Z

Zelić O, Čakić S, Luković N. The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation. in Srpski arhiv za celokupno lekarstvo. 2009;137(1-2):6-9.
doi:10.2298/SARH0902006Z .

Zelić, Obrad, Čakić, Saša, Luković, Natalija, "The effect of two different oral antiseptics on dental plaque formation (De Novo Biofilm) and on gingival inflammation" in Srpski arhiv za celokupno lekarstvo, 137, no. 1-2 (2009):6-9,
https://doi.org/10.2298/SARH0902006Z . .

TY  - JOUR
AU  - Anđelski-Radičević, Biljana
AU  - Zelić, Obrad
AU  - Mirković, Silvija
AU  - Todorović, Tatjana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1417
AB  - Background/Aim. Diabetes mellitus (DM) as a complex metabolic disease influences functioning of numerous organs. Therefore, frequent diabetic complication is chronic periodontitis. The aim of the study was to investigate the influence of various risk factors, like age, sex, duration of DM, oral hygiene, on oral manifestations of diabetes. Methods. The group of diabetics included 52 adult patients, 18-79-year of age, both sexes (33 females, 19 males) out of which 35 patients were with diabetes mellitus type I and 17 with type II. Mean age of the patients was 54.6 years and the mean duration of diabetes was 11.1 years. The controls consited of 67 volunteers from the city of Belgrade, 19-24-year of age, both sexes (47 females, 20 males) with no paradonthopathy and non-systemic diseases. Estimation of periodontal status of the patients was performed by measuring dental plaque index, gingival index and periodontal pockets' depth. Results. The results suggest an increased incidence and severity of periodontitis in diabetic patients. It was established that duration of diabetes, patients' age and bad oral hygiene had a negative influence on status of remained teeth in diabetics, while the sex had no influence on parameters monitored. Conclusion. Indices of oral hygiene level and periodontal status (dental plaque index, gingival index and periodontal pockets' depth) were significantly worsened in patients with diabetes. Negative influence on remained teeth had patients' age (>50 years), duration of diabetes (> 20 years) and bad oral hygiene. About half of the patients had a total or partial bridge suggesting that periodontitis is significant complication of diabetes mellitus.
AB  - Uvod/Cilj. Diabetes mellitus (DM) kao oboljenje u čijoj osnovi jeste metabolički poremećaj odražava se na funkcionisanje brojnih organa. Stoga, česte manifestacije dijabetesa predstavljaju i gingivitis i parodontopatija. Cilj rada bio je da se ispita uticaj različitih faktora (pol, starost, trajanje DM, higijena usta i zuba) na oralne manifestacije dijabetesa. Metode. Ispitana je grupa bolesnika obolelih od DM i kontrolna grupa zdravih osoba. Grupu ispitanika činila su 52 odrasla bolesnika, starosti 18-79 godina, oba pola (33 žene i 19 muškaraca), obolela od dijabetesa melitusa tip 1 (35 ispitanika) i tip 2 (17 ispitanika), lečena u Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Srednja starost ispitanika bila je 54,6 godina, a srednje trajanje dijabetesa 11,1 godina. Kontrolna grupa formirana je od 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta Univerziteta u Beogradu, starosti 19-24 godine, oba pola (47 ženskih i 20 muških), bez parodontopatije i sistemskih bolesti. Status periodoncijuma bolesnika definisan je na osnovu merenja indeksa plaka, gingivnog indeksa i dubine periodontnih džepova. Rezultati. Dobijeni rezultati ukazuju na povećanu učestalost i težinu parodontopatije kod bolesnika sa dijabetesom. Utvrđeno je da značajan negativni uticaj na stanje preostalih zuba kod bolesnika sa dijabetesom imaju dužina trajanja bolesti, starost bolesnika i loša oralna higijena, dok je pol bez uticaja na posmatrane promene. Zaključak. Pokazatelji nivoa oralne higijene i stanje periodontnog tkiva (indeks dentalnog plaka, gingivni indeks, dubina periodontnih džepova) značajno su pogoršani kod dijabetesnih bolesnika. Negativan uticaj na broj preostalih zuba imaju starost (> 50 godina), dužina trajanja dijabetesa (> 20 godina) i loša oralna higijena. Polovinu ispitanih bolesnika zbog gubitka svih ili velikog broja zuba nosi parcijalnu ili totalnu protezu, što pokazuje da je parodontopatija značajna komplikacija DM.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Periodontal condition in diabetics in Belgrade
T1  - Stanje tkiva periodoncijuma kod bolesnika sa dijabetesom melitusom u populaciji Beograda
VL  - 65
IS  - 11
SP  - 799
EP  - 802
DO  - 10.2298/VSP0811799A
ER  - 

@article{
author = "Anđelski-Radičević, Biljana and Zelić, Obrad and Mirković, Silvija and Todorović, Tatjana",
year = "2008",
abstract = "Background/Aim. Diabetes mellitus (DM) as a complex metabolic disease influences functioning of numerous organs. Therefore, frequent diabetic complication is chronic periodontitis. The aim of the study was to investigate the influence of various risk factors, like age, sex, duration of DM, oral hygiene, on oral manifestations of diabetes. Methods. The group of diabetics included 52 adult patients, 18-79-year of age, both sexes (33 females, 19 males) out of which 35 patients were with diabetes mellitus type I and 17 with type II. Mean age of the patients was 54.6 years and the mean duration of diabetes was 11.1 years. The controls consited of 67 volunteers from the city of Belgrade, 19-24-year of age, both sexes (47 females, 20 males) with no paradonthopathy and non-systemic diseases. Estimation of periodontal status of the patients was performed by measuring dental plaque index, gingival index and periodontal pockets' depth. Results. The results suggest an increased incidence and severity of periodontitis in diabetic patients. It was established that duration of diabetes, patients' age and bad oral hygiene had a negative influence on status of remained teeth in diabetics, while the sex had no influence on parameters monitored. Conclusion. Indices of oral hygiene level and periodontal status (dental plaque index, gingival index and periodontal pockets' depth) were significantly worsened in patients with diabetes. Negative influence on remained teeth had patients' age (>50 years), duration of diabetes (> 20 years) and bad oral hygiene. About half of the patients had a total or partial bridge suggesting that periodontitis is significant complication of diabetes mellitus., Uvod/Cilj. Diabetes mellitus (DM) kao oboljenje u čijoj osnovi jeste metabolički poremećaj odražava se na funkcionisanje brojnih organa. Stoga, česte manifestacije dijabetesa predstavljaju i gingivitis i parodontopatija. Cilj rada bio je da se ispita uticaj različitih faktora (pol, starost, trajanje DM, higijena usta i zuba) na oralne manifestacije dijabetesa. Metode. Ispitana je grupa bolesnika obolelih od DM i kontrolna grupa zdravih osoba. Grupu ispitanika činila su 52 odrasla bolesnika, starosti 18-79 godina, oba pola (33 žene i 19 muškaraca), obolela od dijabetesa melitusa tip 1 (35 ispitanika) i tip 2 (17 ispitanika), lečena u Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Srednja starost ispitanika bila je 54,6 godina, a srednje trajanje dijabetesa 11,1 godina. Kontrolna grupa formirana je od 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta Univerziteta u Beogradu, starosti 19-24 godine, oba pola (47 ženskih i 20 muških), bez parodontopatije i sistemskih bolesti. Status periodoncijuma bolesnika definisan je na osnovu merenja indeksa plaka, gingivnog indeksa i dubine periodontnih džepova. Rezultati. Dobijeni rezultati ukazuju na povećanu učestalost i težinu parodontopatije kod bolesnika sa dijabetesom. Utvrđeno je da značajan negativni uticaj na stanje preostalih zuba kod bolesnika sa dijabetesom imaju dužina trajanja bolesti, starost bolesnika i loša oralna higijena, dok je pol bez uticaja na posmatrane promene. Zaključak. Pokazatelji nivoa oralne higijene i stanje periodontnog tkiva (indeks dentalnog plaka, gingivni indeks, dubina periodontnih džepova) značajno su pogoršani kod dijabetesnih bolesnika. Negativan uticaj na broj preostalih zuba imaju starost (> 50 godina), dužina trajanja dijabetesa (> 20 godina) i loša oralna higijena. Polovinu ispitanih bolesnika zbog gubitka svih ili velikog broja zuba nosi parcijalnu ili totalnu protezu, što pokazuje da je parodontopatija značajna komplikacija DM.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Periodontal condition in diabetics in Belgrade, Stanje tkiva periodoncijuma kod bolesnika sa dijabetesom melitusom u populaciji Beograda",
volume = "65",
number = "11",
pages = "799-802",
doi = "10.2298/VSP0811799A"
}

Anđelski-Radičević, B., Zelić, O., Mirković, S.,& Todorović, T.. (2008). Periodontal condition in diabetics in Belgrade. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 65(11), 799-802.
https://doi.org/10.2298/VSP0811799A

Anđelski-Radičević B, Zelić O, Mirković S, Todorović T. Periodontal condition in diabetics in Belgrade. in Vojnosanitetski pregled. 2008;65(11):799-802.
doi:10.2298/VSP0811799A .

Anđelski-Radičević, Biljana, Zelić, Obrad, Mirković, Silvija, Todorović, Tatjana, "Periodontal condition in diabetics in Belgrade" in Vojnosanitetski pregled, 65, no. 11 (2008):799-802,
https://doi.org/10.2298/VSP0811799A . .

TY  - JOUR
AU  - Anđelski-Radičević, Biljana
AU  - Mirković, Silvija
AU  - Todorović, Tatjana
AU  - Zelić, Obrad
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1283
AB  - Introduction: Diabetic patients, beside numerous acute and chronic complications, often have oral manifestations of the disease. Aim: The aim of the study was to establish changes in saliva of diabetic patients in relation to healthy population in order to use saliva in the disease monitoring, as well as the changes depending on the type of diabetes. Materials and methods: The study comprised 52 adult patients of both sexes and at the age between 18 and 79 with Diabetes mellitus type 1 and 2 who were treated at the Institute for endocrinology, diabetes and metabolic disorders of the Clinical center of Serbia. The control group consisted of 67 volunteers from Belgrade, students at the School of Dentistry, aged between 19 and 24. The whole of unstimulated and stimulated saliva was collected and biochemical parameters (glucose, total proteins, albumin, sodium and potassium) were determined by methods commonly used for serum. Results: The results showed that salivary potassium level was increased in saliva of diabetic patients, that of sodium and total proteins was decreased, and glucose and albumin did not show changes compared to the control group. Concentrations of total proteins and potassium were higher in patients with DM type 2, and sodium was higher in DM type 1 (p = 0.05). Conclusion: Diabetic patients often have changes in biochemical composition of saliva.
AB  - Uvod: Kod obolelih od Diabetes mellitus-a (DM), pored brojnih akutnih i hroničnih komplikacija, dolazi i do poremećaja oralne homeostaze. Cilj: Cilj rada bio je da se utvrde promene u biohemijskom sastavu salive dijabetesnih bolesnika u odnosu na zdravu populaciju radi eventualnog korišćenja salive u praćenju toka bolesti, odnosno da se utvrde promene u salivi u odnosu na tip dijabetesa. Materijal i metode: Istraživanje je obuhvatilo 52 odrasla pacijenta oba pola, uzrasta 18-79 godina, obolelih od DM - tip 1 i tip 2, lečenih na Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Kontrolnu grupu činilo je 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta u Beogradu, uzrasta 19-24 godine. Sakupljana je ukupna nestimulisana i stimulisana saliva, a biohemijski parametri (glukoza, ukupni proteini, albumin, natrijum i kalijum) određeni su referentnim metodama za serum. Rezultati: Dobijeni rezultati su pokazali da je u salivi obolelih od dijabetesa koncentracija kalijuma povišena, koncentracija natrijuma i ukupnih proteina snižena, a glukoze i albumina nepromenjena u odnosu na kontrolnu grupu. Koncentracije proteina i kalijuma više su kod obolelih od DM tip 2 nego kod DM tip 1, a koncentracija natrijuma viša je kod DM tip 1 (p = 0.05). Zaključak: Biohemijski sastav salive je ukazao na promene kod dijabetesnih bolesnika.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Changes in the biochemical composition of saliva in diabetic patients
T1  - Promene biohemijskog sastava salive kod dijabetičara
VL  - 53
IS  - 4
SP  - 209
EP  - 216
DO  - 10.2298/SGS0604209A
ER  - 

@article{
author = "Anđelski-Radičević, Biljana and Mirković, Silvija and Todorović, Tatjana and Zelić, Obrad",
year = "2006",
abstract = "Introduction: Diabetic patients, beside numerous acute and chronic complications, often have oral manifestations of the disease. Aim: The aim of the study was to establish changes in saliva of diabetic patients in relation to healthy population in order to use saliva in the disease monitoring, as well as the changes depending on the type of diabetes. Materials and methods: The study comprised 52 adult patients of both sexes and at the age between 18 and 79 with Diabetes mellitus type 1 and 2 who were treated at the Institute for endocrinology, diabetes and metabolic disorders of the Clinical center of Serbia. The control group consisted of 67 volunteers from Belgrade, students at the School of Dentistry, aged between 19 and 24. The whole of unstimulated and stimulated saliva was collected and biochemical parameters (glucose, total proteins, albumin, sodium and potassium) were determined by methods commonly used for serum. Results: The results showed that salivary potassium level was increased in saliva of diabetic patients, that of sodium and total proteins was decreased, and glucose and albumin did not show changes compared to the control group. Concentrations of total proteins and potassium were higher in patients with DM type 2, and sodium was higher in DM type 1 (p = 0.05). Conclusion: Diabetic patients often have changes in biochemical composition of saliva., Uvod: Kod obolelih od Diabetes mellitus-a (DM), pored brojnih akutnih i hroničnih komplikacija, dolazi i do poremećaja oralne homeostaze. Cilj: Cilj rada bio je da se utvrde promene u biohemijskom sastavu salive dijabetesnih bolesnika u odnosu na zdravu populaciju radi eventualnog korišćenja salive u praćenju toka bolesti, odnosno da se utvrde promene u salivi u odnosu na tip dijabetesa. Materijal i metode: Istraživanje je obuhvatilo 52 odrasla pacijenta oba pola, uzrasta 18-79 godina, obolelih od DM - tip 1 i tip 2, lečenih na Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Kontrolnu grupu činilo je 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta u Beogradu, uzrasta 19-24 godine. Sakupljana je ukupna nestimulisana i stimulisana saliva, a biohemijski parametri (glukoza, ukupni proteini, albumin, natrijum i kalijum) određeni su referentnim metodama za serum. Rezultati: Dobijeni rezultati su pokazali da je u salivi obolelih od dijabetesa koncentracija kalijuma povišena, koncentracija natrijuma i ukupnih proteina snižena, a glukoze i albumina nepromenjena u odnosu na kontrolnu grupu. Koncentracije proteina i kalijuma više su kod obolelih od DM tip 2 nego kod DM tip 1, a koncentracija natrijuma viša je kod DM tip 1 (p = 0.05). Zaključak: Biohemijski sastav salive je ukazao na promene kod dijabetesnih bolesnika.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Changes in the biochemical composition of saliva in diabetic patients, Promene biohemijskog sastava salive kod dijabetičara",
volume = "53",
number = "4",
pages = "209-216",
doi = "10.2298/SGS0604209A"
}

Anđelski-Radičević, B., Mirković, S., Todorović, T.,& Zelić, O.. (2006). Changes in the biochemical composition of saliva in diabetic patients. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 53(4), 209-216.
https://doi.org/10.2298/SGS0604209A

Anđelski-Radičević B, Mirković S, Todorović T, Zelić O. Changes in the biochemical composition of saliva in diabetic patients. in Stomatološki glasnik Srbije. 2006;53(4):209-216.
doi:10.2298/SGS0604209A .

Anđelski-Radičević, Biljana, Mirković, Silvija, Todorović, Tatjana, Zelić, Obrad, "Changes in the biochemical composition of saliva in diabetic patients" in Stomatološki glasnik Srbije, 53, no. 4 (2006):209-216,
https://doi.org/10.2298/SGS0604209A . .

TY  - JOUR
AU  - Luković, Natalija
AU  - Zelić, Obrad
AU  - Čakić, Saša
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1290
AB  - Due to the infective nature of periodontal disease several local devices have been used to overcome the limited efficacy of conventional periodontal treatment. However, local concentration of these medicaments, especially over time, raises the question of expediency of their use. Local delivery systems allow the therapeutic agents to be targeted to the diseased site for a long time. These systems, when retained in the periodontal pocket, can release the antimicrobial agents at levels that are 10- to 100-fold higher than the levels that can be delivered by systemic antibiotics. Several different drug delivery systems have been used in controlled clinical trials: fibers, gels and chips. The most frequently used antimicrobials are antibiotics (tetracycline, minocycline), hemotherapeutics (metronidazole), and antiseptics (chlorhexidine dicluconate). In the present paper the method of chlorhexidine chip application is analyzed. We discussed the results of studies that evaluated the efficacy of a controlled-release of biodegradable chlorhexidine chip when used as an adjust to scaling and root planning (SRP) in adult periodontitis.
AB  - U tečenju parodontopatija se lokalno se primenjuju različiti medikamenti, kao efikasna dopuna konvencionalnoj mehaničkoj terapiji. Međutim, koncentracija ovih lekova na mestu primene, posebno u funkciji vremena, ostavlja otvorenim pitanje o svrsishodnosti njihove primene. U novije vreme na tržištu su se pojavili novi sistemi lekova za lokalnu primenu u predelu parodontalnih i gingivalnih džepova. Ovi sistemi omogućavaju postepeno oslobađanje terapijskog agensa u inflami ranom parodontalnom džepu i održavaju koncentraciju leka koja je 10 do 100 puta veća od koncentracije koja se postiže u džepu nakon sistemske primene antibiotika. U kontrolisanim kliničkim istraživanjima je ispitivano nekoliko različitih sistema sa lokalnim oslobađanjem leka - vlakna, gelovi, čipovi. Lekovi koji se najčešće koriste u navedenim sistemima su antibiotici (tetraciklin, minociklin), hemoterapeutici (metronidazol) i antiseptici (hlorheksidin diklukonat). U ovom radu su analizirani rezultati studija koje su se bavile ispitivanjem efikasnosti subgingivalno primenjenog periočipa sa hlorheksidinom i prikazana je metoda njihove primene.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - The use of subgingival chlorhexidine chip in the treatment of periodontal disease
T1  - Primena periočipa sa hlorheksidinom u terapiji parodontopatije
VL  - 53
IS  - 3
SP  - 181
EP  - 188
DO  - 10.2298/SGS0603181L
ER  - 

@article{
author = "Luković, Natalija and Zelić, Obrad and Čakić, Saša",
year = "2006",
abstract = "Due to the infective nature of periodontal disease several local devices have been used to overcome the limited efficacy of conventional periodontal treatment. However, local concentration of these medicaments, especially over time, raises the question of expediency of their use. Local delivery systems allow the therapeutic agents to be targeted to the diseased site for a long time. These systems, when retained in the periodontal pocket, can release the antimicrobial agents at levels that are 10- to 100-fold higher than the levels that can be delivered by systemic antibiotics. Several different drug delivery systems have been used in controlled clinical trials: fibers, gels and chips. The most frequently used antimicrobials are antibiotics (tetracycline, minocycline), hemotherapeutics (metronidazole), and antiseptics (chlorhexidine dicluconate). In the present paper the method of chlorhexidine chip application is analyzed. We discussed the results of studies that evaluated the efficacy of a controlled-release of biodegradable chlorhexidine chip when used as an adjust to scaling and root planning (SRP) in adult periodontitis., U tečenju parodontopatija se lokalno se primenjuju različiti medikamenti, kao efikasna dopuna konvencionalnoj mehaničkoj terapiji. Međutim, koncentracija ovih lekova na mestu primene, posebno u funkciji vremena, ostavlja otvorenim pitanje o svrsishodnosti njihove primene. U novije vreme na tržištu su se pojavili novi sistemi lekova za lokalnu primenu u predelu parodontalnih i gingivalnih džepova. Ovi sistemi omogućavaju postepeno oslobađanje terapijskog agensa u inflami ranom parodontalnom džepu i održavaju koncentraciju leka koja je 10 do 100 puta veća od koncentracije koja se postiže u džepu nakon sistemske primene antibiotika. U kontrolisanim kliničkim istraživanjima je ispitivano nekoliko različitih sistema sa lokalnim oslobađanjem leka - vlakna, gelovi, čipovi. Lekovi koji se najčešće koriste u navedenim sistemima su antibiotici (tetraciklin, minociklin), hemoterapeutici (metronidazol) i antiseptici (hlorheksidin diklukonat). U ovom radu su analizirani rezultati studija koje su se bavile ispitivanjem efikasnosti subgingivalno primenjenog periočipa sa hlorheksidinom i prikazana je metoda njihove primene.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "The use of subgingival chlorhexidine chip in the treatment of periodontal disease, Primena periočipa sa hlorheksidinom u terapiji parodontopatije",
volume = "53",
number = "3",
pages = "181-188",
doi = "10.2298/SGS0603181L"
}

Luković, N., Zelić, O.,& Čakić, S.. (2006). The use of subgingival chlorhexidine chip in the treatment of periodontal disease. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 53(3), 181-188.
https://doi.org/10.2298/SGS0603181L

Luković N, Zelić O, Čakić S. The use of subgingival chlorhexidine chip in the treatment of periodontal disease. in Stomatološki glasnik Srbije. 2006;53(3):181-188.
doi:10.2298/SGS0603181L .

Luković, Natalija, Zelić, Obrad, Čakić, Saša, "The use of subgingival chlorhexidine chip in the treatment of periodontal disease" in Stomatološki glasnik Srbije, 53, no. 3 (2006):181-188,
https://doi.org/10.2298/SGS0603181L . .

TY  - JOUR
AU  - Anđelski, Biljana
AU  - Zelić, Obrad
AU  - Mirković, Silvija
PY  - 2004
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1209
AB  - Diabetes mellitus is often accompanied by periodontitis of different grades and biochemical changes in saliva. Evaluation of periodontal status is performed by measuring dental plaque index, gingival index and periodontal pockets depth. Whole saliva levels of glucose and electrolytes are measured by usual methods for serum. The results reveal that there are no statistically significant changes in saliva glucose levels in diabetic and/or periodontitis patients in relation to healthy population; potassium level is increased in saliva of both experimental groups in relation to controls, and sodium level is decreased. Plaque index, gingival index and periodontal pocket depth are increased in diabetic patients, and tooth loss increases in patients over 50 years of age.
AB  - Dijabetes melitus često je praćen parodontopatijom različitog stepena i promenama u biohemijskom sastavu salive. Parodontalni status pacijenata definisan je na osnovu merenja plak indeksa, gingivalnog indeksa i dubine parodontalnih džepova. Koncentracija glukoze i elektrolita u mešovitoj salivi određene su metodama koje se koriste za ova određivanja u serumu Dobijeni rezultati ukazuju da nema statistički značajne razlike u koncentraciji glukoze u salivi obolelih od dijabetesa i/ili parodontopatije u odnosu na zdravu populaciju. Koncentracija kalijuma u salivi povišena je kod obe eksperimentalne grupe u odnosu na kontrolnu, dok je koncentracija natrijuma u salivi snižena. Prosečne vrednosti plak indeksa, gingivalnog indeksa i dubine parodontalnih džepova povećane su kod dijabetesnih bolesnika, a posle pedesete godine je kod ovih osoba izražena i povećana učestalost gubitka zuba usled parodontopatije.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
T2  - Stomatološki informator
T1  - Biochemical changes in saliva and periodontal status of diabetic patients
T1  - Parodontalni status i biohemijske promene u salivi obolelih od dijabetes melitusa
VL  - 10
IS  - 13
SP  - 5
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_smile_1209
ER  - 

@article{
author = "Anđelski, Biljana and Zelić, Obrad and Mirković, Silvija",
year = "2004",
abstract = "Diabetes mellitus is often accompanied by periodontitis of different grades and biochemical changes in saliva. Evaluation of periodontal status is performed by measuring dental plaque index, gingival index and periodontal pockets depth. Whole saliva levels of glucose and electrolytes are measured by usual methods for serum. The results reveal that there are no statistically significant changes in saliva glucose levels in diabetic and/or periodontitis patients in relation to healthy population; potassium level is increased in saliva of both experimental groups in relation to controls, and sodium level is decreased. Plaque index, gingival index and periodontal pocket depth are increased in diabetic patients, and tooth loss increases in patients over 50 years of age., Dijabetes melitus često je praćen parodontopatijom različitog stepena i promenama u biohemijskom sastavu salive. Parodontalni status pacijenata definisan je na osnovu merenja plak indeksa, gingivalnog indeksa i dubine parodontalnih džepova. Koncentracija glukoze i elektrolita u mešovitoj salivi određene su metodama koje se koriste za ova određivanja u serumu Dobijeni rezultati ukazuju da nema statistički značajne razlike u koncentraciji glukoze u salivi obolelih od dijabetesa i/ili parodontopatije u odnosu na zdravu populaciju. Koncentracija kalijuma u salivi povišena je kod obe eksperimentalne grupe u odnosu na kontrolnu, dok je koncentracija natrijuma u salivi snižena. Prosečne vrednosti plak indeksa, gingivalnog indeksa i dubine parodontalnih džepova povećane su kod dijabetesnih bolesnika, a posle pedesete godine je kod ovih osoba izražena i povećana učestalost gubitka zuba usled parodontopatije.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Stomatološki informator",
title = "Biochemical changes in saliva and periodontal status of diabetic patients, Parodontalni status i biohemijske promene u salivi obolelih od dijabetes melitusa",
volume = "10",
number = "13",
pages = "5-12",
url = "https://hdl.handle.net/21.15107/rcub_smile_1209"
}

Anđelski, B., Zelić, O.,& Mirković, S.. (2004). Biochemical changes in saliva and periodontal status of diabetic patients. in Stomatološki informator
Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 10(13), 5-12.
https://hdl.handle.net/21.15107/rcub_smile_1209

Anđelski B, Zelić O, Mirković S. Biochemical changes in saliva and periodontal status of diabetic patients. in Stomatološki informator. 2004;10(13):5-12.
https://hdl.handle.net/21.15107/rcub_smile_1209 .

Anđelski, Biljana, Zelić, Obrad, Mirković, Silvija, "Biochemical changes in saliva and periodontal status of diabetic patients" in Stomatološki informator, 10, no. 13 (2004):5-12,
https://hdl.handle.net/21.15107/rcub_smile_1209 .

TY  - JOUR
AU  - Zelić, Obrad
AU  - Aleksić, Zoran
AU  - Nedić, Milica
AU  - Crvenica, Đorđije
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1192
AB  - The purpose of this study was to evaluate the effectiveness of a combination of new surgical procedures as a part of regenerative therapy of intrabony defects in humans and compare it to an open flap debridement technique (OFD). The results of this study indicate that the combination technique including bovine porous bone mineral, guided tissue regeneration and growth factor provide better clinical resolution of intrabony defects than treatment with OFD. Results achieved using this experimental technique are also clinically significant since they resulted in pocket reduction and clinical attachment improvement of severe lesions to maintainable levels by supportive periodontal therapy.
AB  - Cilj savremenih principa terapije obolelog parodoncijuma je regeneracija pripojnog aparata i kompletna rekontrukcija parodontalnih tkiva. To se pre svega odnosi na formiranje novog cementa, nove alveolarne kosti i funkcionalnog periodoncijuma na delu korena zuba koji je bio izložen patogenim efektima dentalnog plaka. Sve ove procedure pokazale su izvanredne kliničke rezultate u terapiji različitih oblika koštanih defekata parodoncijuma. To bi značilo da se u skoroj budućnosti mogu očekivati takvi materijali, koji će proces regeneracije tkiva parodoncijuma učiniti stvarnim i mogućim.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad
T2  - Stomatološki informator
T1  - Regenerative surgical procedures in therapy of periodontal osseous defects
T1  - Primena regenerativnih zahvata u terapiji obolelih od paradontopatija
VL  - 9
IS  - 12
SP  - 43
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_smile_1192
ER  - 

@article{
author = "Zelić, Obrad and Aleksić, Zoran and Nedić, Milica and Crvenica, Đorđije",
year = "2003",
abstract = "The purpose of this study was to evaluate the effectiveness of a combination of new surgical procedures as a part of regenerative therapy of intrabony defects in humans and compare it to an open flap debridement technique (OFD). The results of this study indicate that the combination technique including bovine porous bone mineral, guided tissue regeneration and growth factor provide better clinical resolution of intrabony defects than treatment with OFD. Results achieved using this experimental technique are also clinically significant since they resulted in pocket reduction and clinical attachment improvement of severe lesions to maintainable levels by supportive periodontal therapy., Cilj savremenih principa terapije obolelog parodoncijuma je regeneracija pripojnog aparata i kompletna rekontrukcija parodontalnih tkiva. To se pre svega odnosi na formiranje novog cementa, nove alveolarne kosti i funkcionalnog periodoncijuma na delu korena zuba koji je bio izložen patogenim efektima dentalnog plaka. Sve ove procedure pokazale su izvanredne kliničke rezultate u terapiji različitih oblika koštanih defekata parodoncijuma. To bi značilo da se u skoroj budućnosti mogu očekivati takvi materijali, koji će proces regeneracije tkiva parodoncijuma učiniti stvarnim i mogućim.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad",
journal = "Stomatološki informator",
title = "Regenerative surgical procedures in therapy of periodontal osseous defects, Primena regenerativnih zahvata u terapiji obolelih od paradontopatija",
volume = "9",
number = "12",
pages = "43-50",
url = "https://hdl.handle.net/21.15107/rcub_smile_1192"
}

Zelić, O., Aleksić, Z., Nedić, M.,& Crvenica, Đ.. (2003). Regenerative surgical procedures in therapy of periodontal osseous defects. in Stomatološki informator
Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad., 9(12), 43-50.
https://hdl.handle.net/21.15107/rcub_smile_1192

Zelić O, Aleksić Z, Nedić M, Crvenica Đ. Regenerative surgical procedures in therapy of periodontal osseous defects. in Stomatološki informator. 2003;9(12):43-50.
https://hdl.handle.net/21.15107/rcub_smile_1192 .

Zelić, Obrad, Aleksić, Zoran, Nedić, Milica, Crvenica, Đorđije, "Regenerative surgical procedures in therapy of periodontal osseous defects" in Stomatološki informator, 9, no. 12 (2003):43-50,
https://hdl.handle.net/21.15107/rcub_smile_1192 .

TY  - JOUR
AU  - Mirković, Silvija
AU  - Anđelski, Biljana
AU  - Zelić, Obrad
PY  - 2002
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1156
AB  - Whole saliva of persons with different stages of periodontal disease was compared with saliva of patients of different ages, but in terminal stage of periodontal disease. Separation of protein fractions was made by IEF on Servalyt plates. Protein fractions over pHi 8,3 decreased in patients with periodontal disease as well as in older patients.
AB  - Sva elektroforetska ispitivanja pokazala su da je proteinski sastav pljuvačke i stanje parooncijuma u zavisnoj vezi od starosti ispitanika. Posebno se to odnosi na glikoproteinski sastav pljuvačke, koji naročito varira sa starošću organizma. Poznato je da sa starenjem pljuvačka gubi serozne karakteristike, dok je mukusni sekret mnogo zastupljeniji. Takođe promene glikoproteinskih karakteristika mogu ukazati i na enzimske i zaštitne imunoglobulinske promené. Na to ukazuje skraćenje dužine oblasti elektroforegrama u kojima se nalaze bazne proteinske komponente velikih molekulskih masa Mr>60.000, koje odgovaraju globulinskoj i imunoglobulinskoj oblasti razdvajanja. Ispitivanja pojedinačnih uzoraka mešovite pljuvačke pokazuju, u saglasnosti sa stanjem parodontalnih tkiva i godinama starosti a uprkos individualnim razlikama, ujednačen proteinski sastav. Međutim, da bi se mogao izvesti zaključak o proteinskom statusu u stanju svakog stadijuma oboljenja parodoncijuma u vezi sa starenjem ispitanika, primenom pool-ovih uzoraka odstranjuje se svaka individualna razlika koja može ovim postupcima nastati. Sve promené ogledaju se u povećanju zastupljenosti proteinskih frakcija manjih molekulskih masa (Mr lt 60.000), na račun degradacije onih sa većim relativnim molekulskim masama (Mr>60.000). Smanjenje zastupljenosti frakcija glikoproteina baznih karakteristika naročito izostanak lizozima (pHi=10,65), i to na račun frakcija glikoproteina kiselih karakteristika, kao stoje utvrđeno izoelektričnim fokusiranjem, ukazuje na neželjene promené nastale ne samo napredovanjem parodontalnog oboljenja, već i uporedo sa starenjem organizma. Saglasno sa promenama proteinskih frakcija mešovite pljuvačke sa napredovanjem oboljenja parodoncijuma i starenjem organizma u in vivo uslovima, nastaju promené proteinskog sastava mešovite pljuvačke i u in vitro uslovima - "starenjem" zdravog uzorka stajanjem u epruveti duže vreme (1-10 dana) u puferu za uzorak. Moguće objašnjenje svih ovih promena je da se, uprkos stalnom obnavljanju pljuvačke u usnoj duplji, promené proteinskog sastava mogu pripisati razvoju oboljenja parodoncijuma, kao i starenju organizma, jer razvoj bolesti obično nastaje sa godinama (izuzetak je juvenilna parodontopatija). Na ovu pretpostavku ukazuju i destruktivne promené proteina velikih molekulskih masa nastale stajanjem zdravog uzorka mešovite pljuvačke duže vreme u puferu za uzorak.
PB  - Gerontološko društvo Srbije, Beograd
T2  - Gerontologija
T1  - Odnos glikoproteinskih frakcija mešovite pljuvačke i starenje
VL  - 30
IS  - 1
SP  - 196
EP  - 201
UR  - https://hdl.handle.net/21.15107/rcub_smile_1156
ER  - 

@article{
author = "Mirković, Silvija and Anđelski, Biljana and Zelić, Obrad",
year = "2002",
abstract = "Whole saliva of persons with different stages of periodontal disease was compared with saliva of patients of different ages, but in terminal stage of periodontal disease. Separation of protein fractions was made by IEF on Servalyt plates. Protein fractions over pHi 8,3 decreased in patients with periodontal disease as well as in older patients., Sva elektroforetska ispitivanja pokazala su da je proteinski sastav pljuvačke i stanje parooncijuma u zavisnoj vezi od starosti ispitanika. Posebno se to odnosi na glikoproteinski sastav pljuvačke, koji naročito varira sa starošću organizma. Poznato je da sa starenjem pljuvačka gubi serozne karakteristike, dok je mukusni sekret mnogo zastupljeniji. Takođe promene glikoproteinskih karakteristika mogu ukazati i na enzimske i zaštitne imunoglobulinske promené. Na to ukazuje skraćenje dužine oblasti elektroforegrama u kojima se nalaze bazne proteinske komponente velikih molekulskih masa Mr>60.000, koje odgovaraju globulinskoj i imunoglobulinskoj oblasti razdvajanja. Ispitivanja pojedinačnih uzoraka mešovite pljuvačke pokazuju, u saglasnosti sa stanjem parodontalnih tkiva i godinama starosti a uprkos individualnim razlikama, ujednačen proteinski sastav. Međutim, da bi se mogao izvesti zaključak o proteinskom statusu u stanju svakog stadijuma oboljenja parodoncijuma u vezi sa starenjem ispitanika, primenom pool-ovih uzoraka odstranjuje se svaka individualna razlika koja može ovim postupcima nastati. Sve promené ogledaju se u povećanju zastupljenosti proteinskih frakcija manjih molekulskih masa (Mr lt 60.000), na račun degradacije onih sa većim relativnim molekulskim masama (Mr>60.000). Smanjenje zastupljenosti frakcija glikoproteina baznih karakteristika naročito izostanak lizozima (pHi=10,65), i to na račun frakcija glikoproteina kiselih karakteristika, kao stoje utvrđeno izoelektričnim fokusiranjem, ukazuje na neželjene promené nastale ne samo napredovanjem parodontalnog oboljenja, već i uporedo sa starenjem organizma. Saglasno sa promenama proteinskih frakcija mešovite pljuvačke sa napredovanjem oboljenja parodoncijuma i starenjem organizma u in vivo uslovima, nastaju promené proteinskog sastava mešovite pljuvačke i u in vitro uslovima - "starenjem" zdravog uzorka stajanjem u epruveti duže vreme (1-10 dana) u puferu za uzorak. Moguće objašnjenje svih ovih promena je da se, uprkos stalnom obnavljanju pljuvačke u usnoj duplji, promené proteinskog sastava mogu pripisati razvoju oboljenja parodoncijuma, kao i starenju organizma, jer razvoj bolesti obično nastaje sa godinama (izuzetak je juvenilna parodontopatija). Na ovu pretpostavku ukazuju i destruktivne promené proteina velikih molekulskih masa nastale stajanjem zdravog uzorka mešovite pljuvačke duže vreme u puferu za uzorak.",
publisher = "Gerontološko društvo Srbije, Beograd",
journal = "Gerontologija",
title = "Odnos glikoproteinskih frakcija mešovite pljuvačke i starenje",
volume = "30",
number = "1",
pages = "196-201",
url = "https://hdl.handle.net/21.15107/rcub_smile_1156"
}

Mirković, S., Anđelski, B.,& Zelić, O.. (2002). Odnos glikoproteinskih frakcija mešovite pljuvačke i starenje. in Gerontologija
Gerontološko društvo Srbije, Beograd., 30(1), 196-201.
https://hdl.handle.net/21.15107/rcub_smile_1156

Mirković S, Anđelski B, Zelić O. Odnos glikoproteinskih frakcija mešovite pljuvačke i starenje. in Gerontologija. 2002;30(1):196-201.
https://hdl.handle.net/21.15107/rcub_smile_1156 .

Mirković, Silvija, Anđelski, Biljana, Zelić, Obrad, "Odnos glikoproteinskih frakcija mešovite pljuvačke i starenje" in Gerontologija, 30, no. 1 (2002):196-201,
https://hdl.handle.net/21.15107/rcub_smile_1156 .

TY  - JOUR
AU  - Muković, Silvija
AU  - Zelić, Obrad
AU  - Anđelski, Biljana
PY  - 2002
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1142
AB  - The purpose of this work was to determine the protein composition of whole saliva in 50 year-old patients an d older with manifested and terminal stages of periodontal disease, in correlation with control group of young healthy persons. Experimental and control group consisted of 30 patients. The periodontal status was determinate by using appropriate periodontal index (Sillness-Loe). Investigations were led by electrophoretic method on aragose gel which was used as a routine method for investigation of human serum proteins. Investigating in very alkaline conditions (pH-H) as well as acid conditions (pH=5.9) resulted in separating alkaline and acid glycoprotein fractions in whole saliva. Results showed that there were more separated fractions within basic conditions than within acid conditions. The fraction identification was done by using relative molecule mass determination method by Weber and Osborne. Molecule mass fractions at basic conditions in comparison with the healthy sample (Sz) indicated the destruction of big molecular weight alkaline proteins as well as a significant presence of acid fractions, of little molecule masses up to 60 000 (St), consequences due to aging processes in human organism. It can be concluded that changes in protein composition of whole saliva could point out to the direction and development of periodontal disease as well as changes concerning aging of human organism.
AB  - Cilj ovog rada bio je da se utvrdi proteinski sastav mešovite pljuvačke osoba starih preko 50 godinu su manifestnim i terminalnim oblicima parodontopatije, u odnosu na kontrolnu grupu mladih zdravih osoba. Eksperimentalna i kontrolna grupa sastojale su se od po 30 pacijenata, a parodontalni status je određen primenom parodontalnih indeksa (Sillness-Loe). Ispitivanja su vršena elektroforetskom metodom na agaroznom gelu, koja kao rutinska metoda služi za ispitivanje proteina humanog seruma. Elektroforetskim ispitivanjem u baznim uslovima (pri pH = 11), kao i u kiselim (pri pH = 5.9) razdvojene su sve kisele i bazne proteinske frakcije mešovite pljuvačke. Dobijeni rezultati su pokazali da je u baznim uslovima razdvojeno više frakcija nego u kiseloj sredini (9 pojedinačnih frakcija). Identifikacija frakcija izvršena je metodom za određivanje relativnih molekulskih masa po Webenu i Osbornu. Molekulske mase frakcija u baznim uslovima, u odnosu na zdrav uzorak (Sz) ukazuju na destrukciju baznih proteina velikih molekulskih masa i značajnije prisustvo frakcija kiselih karakteristika, malih molekulskih masa do 60 000 (St), kao posledice parodontopatije nastale starenjem organizma. Može se zaključiti da promene proteinskog sastava pljuvačke mogu ukazati na tok i razvoj oboljenja parodoncijuma, ali i na promene vezane za starenje organizma.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Analysis of protein compounds in old persons whole saliva with parodontal diseases
T1  - Analiza proteinskog sastava mešovite pljuvačke starih osoba obolelih od paradontopatije
VL  - 49
IS  - 1-2
SP  - 29
EP  - 33
DO  - 10.2298/SGS0202029M
ER  - 

@article{
author = "Muković, Silvija and Zelić, Obrad and Anđelski, Biljana",
year = "2002",
abstract = "The purpose of this work was to determine the protein composition of whole saliva in 50 year-old patients an d older with manifested and terminal stages of periodontal disease, in correlation with control group of young healthy persons. Experimental and control group consisted of 30 patients. The periodontal status was determinate by using appropriate periodontal index (Sillness-Loe). Investigations were led by electrophoretic method on aragose gel which was used as a routine method for investigation of human serum proteins. Investigating in very alkaline conditions (pH-H) as well as acid conditions (pH=5.9) resulted in separating alkaline and acid glycoprotein fractions in whole saliva. Results showed that there were more separated fractions within basic conditions than within acid conditions. The fraction identification was done by using relative molecule mass determination method by Weber and Osborne. Molecule mass fractions at basic conditions in comparison with the healthy sample (Sz) indicated the destruction of big molecular weight alkaline proteins as well as a significant presence of acid fractions, of little molecule masses up to 60 000 (St), consequences due to aging processes in human organism. It can be concluded that changes in protein composition of whole saliva could point out to the direction and development of periodontal disease as well as changes concerning aging of human organism., Cilj ovog rada bio je da se utvrdi proteinski sastav mešovite pljuvačke osoba starih preko 50 godinu su manifestnim i terminalnim oblicima parodontopatije, u odnosu na kontrolnu grupu mladih zdravih osoba. Eksperimentalna i kontrolna grupa sastojale su se od po 30 pacijenata, a parodontalni status je određen primenom parodontalnih indeksa (Sillness-Loe). Ispitivanja su vršena elektroforetskom metodom na agaroznom gelu, koja kao rutinska metoda služi za ispitivanje proteina humanog seruma. Elektroforetskim ispitivanjem u baznim uslovima (pri pH = 11), kao i u kiselim (pri pH = 5.9) razdvojene su sve kisele i bazne proteinske frakcije mešovite pljuvačke. Dobijeni rezultati su pokazali da je u baznim uslovima razdvojeno više frakcija nego u kiseloj sredini (9 pojedinačnih frakcija). Identifikacija frakcija izvršena je metodom za određivanje relativnih molekulskih masa po Webenu i Osbornu. Molekulske mase frakcija u baznim uslovima, u odnosu na zdrav uzorak (Sz) ukazuju na destrukciju baznih proteina velikih molekulskih masa i značajnije prisustvo frakcija kiselih karakteristika, malih molekulskih masa do 60 000 (St), kao posledice parodontopatije nastale starenjem organizma. Može se zaključiti da promene proteinskog sastava pljuvačke mogu ukazati na tok i razvoj oboljenja parodoncijuma, ali i na promene vezane za starenje organizma.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Analysis of protein compounds in old persons whole saliva with parodontal diseases, Analiza proteinskog sastava mešovite pljuvačke starih osoba obolelih od paradontopatije",
volume = "49",
number = "1-2",
pages = "29-33",
doi = "10.2298/SGS0202029M"
}

Muković, S., Zelić, O.,& Anđelski, B.. (2002). Analysis of protein compounds in old persons whole saliva with parodontal diseases. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 49(1-2), 29-33.
https://doi.org/10.2298/SGS0202029M

Muković S, Zelić O, Anđelski B. Analysis of protein compounds in old persons whole saliva with parodontal diseases. in Stomatološki glasnik Srbije. 2002;49(1-2):29-33.
doi:10.2298/SGS0202029M .

Muković, Silvija, Zelić, Obrad, Anđelski, Biljana, "Analysis of protein compounds in old persons whole saliva with parodontal diseases" in Stomatološki glasnik Srbije, 49, no. 1-2 (2002):29-33,
https://doi.org/10.2298/SGS0202029M . .

TY  - THES
AU  - Zelić, Obrad
PY  - 1978
UR  - https://plus.sr.cobiss.net/opac7/bib/33389580
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/82
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Savremena terapija progresivnih paradontopatija
UR  - https://hdl.handle.net/21.15107/rcub_smile_82
ER  - 

@phdthesis{
author = "Zelić, Obrad",
year = "1978",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Savremena terapija progresivnih paradontopatija",
url = "https://hdl.handle.net/21.15107/rcub_smile_82"
}

Zelić, O.. (1978). Savremena terapija progresivnih paradontopatija. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_82

Zelić O. Savremena terapija progresivnih paradontopatija. 1978;.
https://hdl.handle.net/21.15107/rcub_smile_82 .

Zelić, Obrad, "Savremena terapija progresivnih paradontopatija" (1978),
https://hdl.handle.net/21.15107/rcub_smile_82 .

TY  - THES
AU  - Zelić, Obrad
PY  - 1975
UR  - https://plus.sr.cobiss.net/opac7/bib/1024044430
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/36
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Rendgenografski nalaz u progresivnoj parodontopatiji
UR  - https://hdl.handle.net/21.15107/rcub_smile_36
ER  - 

@mastersthesis{
author = "Zelić, Obrad",
year = "1975",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Rendgenografski nalaz u progresivnoj parodontopatiji",
url = "https://hdl.handle.net/21.15107/rcub_smile_36"
}

Zelić, O.. (1975). Rendgenografski nalaz u progresivnoj parodontopatiji. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_36

Zelić O. Rendgenografski nalaz u progresivnoj parodontopatiji. 1975;.
https://hdl.handle.net/21.15107/rcub_smile_36 .

Zelić, Obrad, "Rendgenografski nalaz u progresivnoj parodontopatiji" (1975),
https://hdl.handle.net/21.15107/rcub_smile_36 .