TY  - JOUR
AU  - Canullo, Luigi
AU  - Pesce, Paolo
AU  - Botticelli, Daniele
AU  - Covani, Ugo
AU  - Janković, Saša
AU  - Jovanović, Tanja
AU  - Rakić, Mia
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2309
AB  - Purpose: To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. Materials and Methods: Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. Results: The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. Conclusion: EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.
PB  - Quintessence Publishing Co Inc, Hanover Park
T2  - International Journal of Oral & Maxillofacial Implants
T1  - What is the Impact of Epstein-Barr Virus in Peri-implant Infection?
VL  - 33
IS  - 1
SP  - 58
EP  - 63
DO  - 10.11607/jomi.5972
ER  - 

@article{
author = "Canullo, Luigi and Pesce, Paolo and Botticelli, Daniele and Covani, Ugo and Janković, Saša and Jovanović, Tanja and Rakić, Mia",
year = "2018",
abstract = "Purpose: To compare the qualitative and quantitative profile of Epstein-Barr virus (EBV) at external and internal implant surfaces between participants with peri-implantitis and healthy peri-implant tissues and to quantitatively assess the relation between EBV and periopathogens inside the microbiologic profile associated with peri-implantitis. Materials and Methods: Microbiologic specimens were retrieved from 84 patients wearing 190 implants to estimate the levels of EBV and 10 periopathogens in the peri-implant pocket and internal-implant connection using quantitative polymerase chain reaction. Results: The study sample consisted of 113 healthy and 77 peri-implantitis-affected implants. Statistical significance was not reached in EBV prevalence between peri-implantitis and healthy controls. EBV-positive participants demonstrated higher levels of Prevotella intermedia (Pi) and Campylobacter rectus (Cr) compared with EBV-negative participants. A positive correlation was demonstrated among EBV and Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), and Cr levels in peri-implantitis-affected implants, while healthy controls demonstrated a positive correlation between EBV and Aggregatibacter actinomycetemcomitans (Aa), Pi, and Pm. Conclusion: EBV cannot be considered as a microbiologic marker of peri-implantitis. However, EBV could be considered as a risk factor and a peri-implantitis enhancer based on its positive correlations with pathogens associated with peri-implantitis.",
publisher = "Quintessence Publishing Co Inc, Hanover Park",
journal = "International Journal of Oral & Maxillofacial Implants",
title = "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?",
volume = "33",
number = "1",
pages = "58-63",
doi = "10.11607/jomi.5972"
}

Canullo, L., Pesce, P., Botticelli, D., Covani, U., Janković, S., Jovanović, T.,& Rakić, M.. (2018). What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in International Journal of Oral & Maxillofacial Implants
Quintessence Publishing Co Inc, Hanover Park., 33(1), 58-63.
https://doi.org/10.11607/jomi.5972

Canullo L, Pesce P, Botticelli D, Covani U, Janković S, Jovanović T, Rakić M. What is the Impact of Epstein-Barr Virus in Peri-implant Infection?. in International Journal of Oral & Maxillofacial Implants. 2018;33(1):58-63.
doi:10.11607/jomi.5972 .

Canullo, Luigi, Pesce, Paolo, Botticelli, Daniele, Covani, Ugo, Janković, Saša, Jovanović, Tanja, Rakić, Mia, "What is the Impact of Epstein-Barr Virus in Peri-implant Infection?" in International Journal of Oral & Maxillofacial Implants, 33, no. 1 (2018):58-63,
https://doi.org/10.11607/jomi.5972 . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Nikolić, Ljubinka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Plećaš, Darko
AU  - Madianos, Phoebus N.
AU  - Čakić, Saša
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2137
AB  - Background: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.
PB  - Wiley, Hoboken
T2  - Journal of Periodontology
T1  - The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study
VL  - 87
IS  - 3
SP  - 248
EP  - 256
DO  - 10.1902/jop.2015.150364
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Nikolić, Ljubinka and Janković, Saša and Aleksić, Zoran and Plećaš, Darko and Madianos, Phoebus N. and Čakić, Saša",
year = "2016",
abstract = "Background: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.",
publisher = "Wiley, Hoboken",
journal = "Journal of Periodontology",
title = "The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study",
volume = "87",
number = "3",
pages = "248-256",
doi = "10.1902/jop.2015.150364"
}

Perunović, N., Rakić, M., Nikolić, L., Janković, S., Aleksić, Z., Plećaš, D., Madianos, P. N.,& Čakić, S.. (2016). The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study. in Journal of Periodontology
Wiley, Hoboken., 87(3), 248-256.
https://doi.org/10.1902/jop.2015.150364

Perunović N, Rakić M, Nikolić L, Janković S, Aleksić Z, Plećaš D, Madianos PN, Čakić S. The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study. in Journal of Periodontology. 2016;87(3):248-256.
doi:10.1902/jop.2015.150364 .

Perunović, Neda, Rakić, Mia, Nikolić, Ljubinka, Janković, Saša, Aleksić, Zoran, Plećaš, Darko, Madianos, Phoebus N., Čakić, Saša, "The Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Study" in Journal of Periodontology, 87, no. 3 (2016):248-256,
https://doi.org/10.1902/jop.2015.150364 . .

TY  - JOUR
AU  - Perunović, Neda
AU  - Rakić, Mia
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Struillou, Xavier
AU  - Čakić, Saša
AU  - Puletić, Miljan
AU  - Leković, Vojislav
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2058
AB  - The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.
PB  - Quintessence Publishing Co. Inc.
T2  - International Journal of Periodontics & Restorative Dentistry
T1  - MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions
VL  - 35
IS  - 2
SP  - 263
EP  - 269
DO  - 10.11607/prd.2087
ER  - 

@article{
author = "Perunović, Neda and Rakić, Mia and Janković, Saša and Aleksić, Zoran and Struillou, Xavier and Čakić, Saša and Puletić, Miljan and Leković, Vojislav and Milašin, Jelena",
year = "2015",
abstract = "The objective of this pilot study was to investigate the potential role of-1562 C>T single nucleotide polymorphism (SNP) in the promoter region of the matrix metalloproteinase-9 (MMP-9) gene as a risk modulator in the development of multiple gingival recessions (MGRs) in young adults in the Serbian population. The study sample comprised 161 systemically healthy people: 60 with MGRs and 101 controls with healthy periodontal tissues. Genotyping was done using polymerase chain reaction/restriction fragment length polymorphism approach on DNA obtained from buccal swabs. Clinical measurements included vertical recession depth (VRD), clinical attachment level (CAL), keratinized gingival width (KGW), visible plaque index (PI), and bleeding on probing (BOP). Heterozygotes (CT) were significantly more frequent in the MGRs group than in the control group (P = .005) and carriers of the T allele had an approximately threefold increase of MGRs risk. Patients with the CT genotype exhibited significantly higher values of VRD and CAL and significantly lower values of KGW than patients with the wildtype genotype. Associations among different genotypes and periodontal biotypes in the MGRs group remained insignificant because all participants exhibited thin biotype. The 1562 C>T SNP in the promoter region of MMP-9 appears to be a risk factor for MGR development and a potential predictor of more severe clinical phenotype.",
publisher = "Quintessence Publishing Co. Inc.",
journal = "International Journal of Periodontics & Restorative Dentistry",
title = "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions",
volume = "35",
number = "2",
pages = "263-269",
doi = "10.11607/prd.2087"
}

Perunović, N., Rakić, M., Janković, S., Aleksić, Z., Struillou, X., Čakić, S., Puletić, M., Leković, V.,& Milašin, J.. (2015). MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry
Quintessence Publishing Co. Inc.., 35(2), 263-269.
https://doi.org/10.11607/prd.2087

Perunović N, Rakić M, Janković S, Aleksić Z, Struillou X, Čakić S, Puletić M, Leković V, Milašin J. MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions. in International Journal of Periodontics & Restorative Dentistry. 2015;35(2):263-269.
doi:10.11607/prd.2087 .

Perunović, Neda, Rakić, Mia, Janković, Saša, Aleksić, Zoran, Struillou, Xavier, Čakić, Saša, Puletić, Miljan, Leković, Vojislav, Milašin, Jelena, "MMP-9-1562 C > T (rs3918242) Promoter Polymorphism as a Susceptibility Factor for Multiple Gingival Recessions" in International Journal of Periodontics & Restorative Dentistry, 35, no. 2 (2015):263-269,
https://doi.org/10.11607/prd.2087 . .

TY  - JOUR
AU  - Novaković, N.
AU  - Todorović, Tatjana
AU  - Rakić, Mia
AU  - Milinković, Iva
AU  - Dožić, Ivan
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Čakić, Saša
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1880
AB  - Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Periodontal Research
T1  - Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome
VL  - 49
IS  - 1
SP  - 129
EP  - 136
DO  - 10.1111/jre.12088
ER  - 

@article{
author = "Novaković, N. and Todorović, Tatjana and Rakić, Mia and Milinković, Iva and Dožić, Ivan and Janković, Saša and Aleksić, Zoran and Čakić, Saša",
year = "2014",
abstract = "Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Periodontal Research",
title = "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome",
volume = "49",
number = "1",
pages = "129-136",
doi = "10.1111/jre.12088"
}

Novaković, N., Todorović, T., Rakić, M., Milinković, I., Dožić, I., Janković, S., Aleksić, Z.,& Čakić, S.. (2014). Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research
Wiley-Blackwell, Hoboken., 49(1), 129-136.
https://doi.org/10.1111/jre.12088

Novaković N, Todorović T, Rakić M, Milinković I, Dožić I, Janković S, Aleksić Z, Čakić S. Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research. 2014;49(1):129-136.
doi:10.1111/jre.12088 .

Novaković, N., Todorović, Tatjana, Rakić, Mia, Milinković, Iva, Dožić, Ivan, Janković, Saša, Aleksić, Zoran, Čakić, Saša, "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome" in Journal of Periodontal Research, 49, no. 1 (2014):129-136,
https://doi.org/10.1111/jre.12088 . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Leković, Vojislav
AU  - Nikolić-Jakoba, Nataša
AU  - Vojvodić, Danilo
AU  - Petković-Ćurčin, Aleksandra
AU  - Sanz, Mariano
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1824
AB  - Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Bone loss biomarkers associated with peri-implantitis. A cross-sectional study
VL  - 24
IS  - 10
SP  - 1110
EP  - 1116
DO  - 10.1111/j.1600-0501.2012.02518.x
ER  - 

@article{
author = "Rakić, Mia and Leković, Vojislav and Nikolić-Jakoba, Nataša and Vojvodić, Danilo and Petković-Ćurčin, Aleksandra and Sanz, Mariano",
year = "2013",
abstract = "Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study",
volume = "24",
number = "10",
pages = "1110-1116",
doi = "10.1111/j.1600-0501.2012.02518.x"
}

Rakić, M., Leković, V., Nikolić-Jakoba, N., Vojvodić, D., Petković-Ćurčin, A.,& Sanz, M.. (2013). Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research
Wiley, Hoboken., 24(10), 1110-1116.
https://doi.org/10.1111/j.1600-0501.2012.02518.x

Rakić M, Leković V, Nikolić-Jakoba N, Vojvodić D, Petković-Ćurčin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research. 2013;24(10):1110-1116.
doi:10.1111/j.1600-0501.2012.02518.x .

Rakić, Mia, Leković, Vojislav, Nikolić-Jakoba, Nataša, Vojvodić, Danilo, Petković-Ćurčin, Aleksandra, Sanz, Mariano, "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study" in Clinical Oral Implants Research, 24, no. 10 (2013):1110-1116,
https://doi.org/10.1111/j.1600-0501.2012.02518.x . .

TY  - JOUR
AU  - Rakić, Mia
AU  - Nikolić-Jakoba, Nataša
AU  - Struillou, Xavier
AU  - Petković-Ćurčin, Aleksandra
AU  - Stamatović, Novak
AU  - Matić, Smiljka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Vasilić, Đurđa
AU  - Leković, Vojislav
AU  - Vojvodić, Danilo
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1778
AB  - Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies.
AB  - Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis
T1  - Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa
VL  - 70
IS  - 4
SP  - 346
EP  - 351
DO  - 10.2298/VSP1304346R
ER  - 

@article{
author = "Rakić, Mia and Nikolić-Jakoba, Nataša and Struillou, Xavier and Petković-Ćurčin, Aleksandra and Stamatović, Novak and Matić, Smiljka and Janković, Saša and Aleksić, Zoran and Vasilić, Đurđa and Leković, Vojislav and Vojvodić, Danilo",
year = "2013",
abstract = "Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies., Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis, Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa",
volume = "70",
number = "4",
pages = "346-351",
doi = "10.2298/VSP1304346R"
}

Rakić, M., Nikolić-Jakoba, N., Struillou, X., Petković-Ćurčin, A., Stamatović, N., Matić, S., Janković, S., Aleksić, Z., Vasilić, Đ., Leković, V.,& Vojvodić, D.. (2013). Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 346-351.
https://doi.org/10.2298/VSP1304346R

Rakić M, Nikolić-Jakoba N, Struillou X, Petković-Ćurčin A, Stamatović N, Matić S, Janković S, Aleksić Z, Vasilić Đ, Leković V, Vojvodić D. Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled. 2013;70(4):346-351.
doi:10.2298/VSP1304346R .

Rakić, Mia, Nikolić-Jakoba, Nataša, Struillou, Xavier, Petković-Ćurčin, Aleksandra, Stamatović, Novak, Matić, Smiljka, Janković, Saša, Aleksić, Zoran, Vasilić, Đurđa, Leković, Vojislav, Vojvodić, Danilo, "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis" in Vojnosanitetski pregled, 70, no. 4 (2013):346-351,
https://doi.org/10.2298/VSP1304346R . .

TY  - JOUR
AU  - Petrović, Vanja
AU  - Pejčić, Nataša
AU  - Rakić, Mia
AU  - Leković, Vojislav
AU  - Vasić, Una
AU  - Stojić, Ž.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1707
AB  - Platelet-reach plasma (PRP) is an attractive tool in regenerative medicine due to its ability to stimulate proliferation and differentiation of stem cells. Since dental pulp derived stem cells are recognized as central in apexogenesis, the aim of the study was to evaluate radiologically and histologically effects of PRP on apexogenesis in teeth with immature roots. The study included eight monkeys (Cercopithecus Aethiops) divided in two equal groups for evaluation 3 and 12 months after treatment. All participants obtained the same treatment including pulpotomy and after-treatment with: hydroxiapatite (HA)-incisor and HA+canine PRP. Radiological evaluation was performed using the long cone paralleling technique for recording of defined parameters and histological evaluation was performed using tissue removed en block for the observation of parameters related to apexogenesis. The results obtained radiologically and histologically have shown increase in bridge formation in HA+PRP (75%) group after 3 months comparing to HA group (50%). Contrary to that, after 12 months there were no significant differences between groups. The root delay was not registered in the HA+PRP group contrary to HA group where it was registered in 25% after 12 months. Results of the study suggest that PRP is a powerful tool for intensive and rapid apexogenesis since it offers clear and comprehensive results (mostly in the first three months) which are early radiologically visible without any failure in the proposed requests.
AB  - Primena plazme bogate trombocitima (PRP) predstavlja atraktivnu metodu u savremenoj regenerativnoj medicini zbog toga što ona ima sposobnost da stimuliš e proliferaciju i diferencijaciju stem ćelija. Kako su stem ćelije poreklom od dentalne pulpe definisane kao glavne u procesu apeksogeneze, cilj ove studije je bio da radiološki i histološki evaluira efekat PRP na apeksogenezu zuba sa nedovrš enim rastom korena. Studija je obuhvatila 8 majmuna (Cercopithecus Aethiops) koji su bili podeljeni u dve jednake grupe za evaluiranje, 3 i 12 meseci nakon terapije. Sve životinje su bile podvrgnute istom tretmanu uključujući pulpotomiju i tretman: hidroksiapatitom (HA) - sekutići i HA+PRP - očnjaci. Radiološka evaluacija je urađena određivanjem zadatih parametara na radiogramima dobijenim paralelnom tehnikom dugog konusa, a histološka analiza je sprovedena analiziranjem parametara svojstvenih apeksogenezi u preparatima uzetim 'en blok' tehnikom. Dobijeni rezultati su radiološki i histološki za dentinski most posle 3 meseca ukazali na porast u grupi HA+PRP (75%) u poređenju sa HA grupom (50%). Nasuprot tome, posle 12 meseci nije bilo razlike među grupama. Zaostatak u razvoju korena nije utvrđen u HA+PRP grupi za razliku od HA grupe gde je utvrđen zaostatak u 25% slučajeva. Rezultati studije navode na zaključak da je PRP moćno sredstvo za brzu i intezivnu apeksogenezu zbog toga što daje jasne i sveobuhvatne rezultate (najviše u prva tri meseca), koji su radiološki rano vidljivi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation
T1  - Efekti plazme bogate trombocitima na apeksogenezu kod mladih majmuna - radiološka i histološka evaluacija
VL  - 62
IS  - 1
SP  - 39
EP  - 52
DO  - 10.2298/AVB1201039P
ER  - 

@article{
author = "Petrović, Vanja and Pejčić, Nataša and Rakić, Mia and Leković, Vojislav and Vasić, Una and Stojić, Ž.",
year = "2012",
abstract = "Platelet-reach plasma (PRP) is an attractive tool in regenerative medicine due to its ability to stimulate proliferation and differentiation of stem cells. Since dental pulp derived stem cells are recognized as central in apexogenesis, the aim of the study was to evaluate radiologically and histologically effects of PRP on apexogenesis in teeth with immature roots. The study included eight monkeys (Cercopithecus Aethiops) divided in two equal groups for evaluation 3 and 12 months after treatment. All participants obtained the same treatment including pulpotomy and after-treatment with: hydroxiapatite (HA)-incisor and HA+canine PRP. Radiological evaluation was performed using the long cone paralleling technique for recording of defined parameters and histological evaluation was performed using tissue removed en block for the observation of parameters related to apexogenesis. The results obtained radiologically and histologically have shown increase in bridge formation in HA+PRP (75%) group after 3 months comparing to HA group (50%). Contrary to that, after 12 months there were no significant differences between groups. The root delay was not registered in the HA+PRP group contrary to HA group where it was registered in 25% after 12 months. Results of the study suggest that PRP is a powerful tool for intensive and rapid apexogenesis since it offers clear and comprehensive results (mostly in the first three months) which are early radiologically visible without any failure in the proposed requests., Primena plazme bogate trombocitima (PRP) predstavlja atraktivnu metodu u savremenoj regenerativnoj medicini zbog toga što ona ima sposobnost da stimuliš e proliferaciju i diferencijaciju stem ćelija. Kako su stem ćelije poreklom od dentalne pulpe definisane kao glavne u procesu apeksogeneze, cilj ove studije je bio da radiološki i histološki evaluira efekat PRP na apeksogenezu zuba sa nedovrš enim rastom korena. Studija je obuhvatila 8 majmuna (Cercopithecus Aethiops) koji su bili podeljeni u dve jednake grupe za evaluiranje, 3 i 12 meseci nakon terapije. Sve životinje su bile podvrgnute istom tretmanu uključujući pulpotomiju i tretman: hidroksiapatitom (HA) - sekutići i HA+PRP - očnjaci. Radiološka evaluacija je urađena određivanjem zadatih parametara na radiogramima dobijenim paralelnom tehnikom dugog konusa, a histološka analiza je sprovedena analiziranjem parametara svojstvenih apeksogenezi u preparatima uzetim 'en blok' tehnikom. Dobijeni rezultati su radiološki i histološki za dentinski most posle 3 meseca ukazali na porast u grupi HA+PRP (75%) u poređenju sa HA grupom (50%). Nasuprot tome, posle 12 meseci nije bilo razlike među grupama. Zaostatak u razvoju korena nije utvrđen u HA+PRP grupi za razliku od HA grupe gde je utvrđen zaostatak u 25% slučajeva. Rezultati studije navode na zaključak da je PRP moćno sredstvo za brzu i intezivnu apeksogenezu zbog toga što daje jasne i sveobuhvatne rezultate (najviše u prva tri meseca), koji su radiološki rano vidljivi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation, Efekti plazme bogate trombocitima na apeksogenezu kod mladih majmuna - radiološka i histološka evaluacija",
volume = "62",
number = "1",
pages = "39-52",
doi = "10.2298/AVB1201039P"
}

Petrović, V., Pejčić, N., Rakić, M., Leković, V., Vasić, U.,& Stojić, Ž.. (2012). Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(1), 39-52.
https://doi.org/10.2298/AVB1201039P

Petrović V, Pejčić N, Rakić M, Leković V, Vasić U, Stojić Ž. Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation. in Acta veterinaria. 2012;62(1):39-52.
doi:10.2298/AVB1201039P .

Petrović, Vanja, Pejčić, Nataša, Rakić, Mia, Leković, Vojislav, Vasić, Una, Stojić, Ž., "Effects of the platelet rich plasma on apexogenesis in young monkeys: Radiological and hystologycal evaluation" in Acta veterinaria, 62, no. 1 (2012):39-52,
https://doi.org/10.2298/AVB1201039P . .

TY  - THES
AU  - Rakić, Mia
PY  - 2012
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=584
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:6743/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1024187278
UR  - http://nardus.mpn.gov.rs/123456789/2684
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/957
AB  - Peri-implantitis is inflammatory process characterized by supporting bone loss of loaded oral implants. The pathognomonic characteristic of peri-implantitis is supporting bone loss of the loaded implant. This process is based on inflammatory osteoclastogenesis which simultaneously represent the central pathologic process of the disorder. Inflammatory osteoclastogenesis implies maturation of pre-osteoclasts and enhancement of the activity of maturated osteoclasts which are induced by achieving of the critical concentrations of proinflammatory mediators. Clinical characteristics of the peri-implantitis are still not strictly defined and they vary because in the physiological conditions the values of clinical parameters varies among individuals, for example peri-implant sulcus depth represents the individual determinant which could be from 0.5mm to 4mm as well. Simultaneously, the marginal bone loss is the physiological characteristic around implants in function, which is the most intensive in the first year of loading represented by the -0.78mm in the mesial sites and -0.85mm at the distal sites, and after that the process is constant and bone loss at the year level is approximately 0.2mm. The mentioned value is the average values that individually vary and it depends of the implant type, abutments and numerous other factors. From that reason the relative clinical attachment level (rCAL), nether radiological proof of bone loss could be accepted as the absolute indicators of the pathological bone loss. In the peri-implant diagnostics the most frequently are used the few different diagnostic procedures in the combination to give the complete diagnostic view. These diagnostic methods include: evaluation of clinical parameters, radiological analyses, microbiological analyses and quantitative and qualitative analyses of PICF. The PICF analysis is one of the most attractive methods in current implantology, where the one of the most precious values is providing of the direct information on peri-implant tissues d based on that providing information on early disease onset in the phase of reversible damage. This limitation of clinical methods results in time loss proportionally decreasing treatment success, and frequently resulting in inappropriate treatment planning. Based on that, evaluation of biomarkers in PICF sample compensates limitations of conventional diagnostic procedures without capability to provide accurate information on early disease. Numerous studies have been conducted to identify the biomolecules accurately reflecting peri-implant tissue condition, but since the pathology of local metabolism is complex, the method for evaluation is still under standardization...
AB  - Peri-implantitis predstavlja inflamatorni proces koji se karakteriše gubitkom potporne kosti opterećenog oralnog implantata. Osnovna patološka karakteristika peri-implantitisa je gubitak potporne kosti implantata u funkciji. Ovaj proces je zasnovan na inflamatornoj osteoklastogenezi koja ujedno predstavlja centralni patološki proces peri-implantitisa. Inflamatorna osteoklastogeneza predstavlja proces sazrevanja pre-osteoklasta i pojačavanje aktivnosti zrelih osteoklasta pod uticajem kritičnih koncentracija pro-inflamatornih medijatora. Kliničke karakteristike peri-implantitisa nisu strogo definisane i variraju iz prostog razloga jer dubina peri-implantnog sulkusa značajno varira s'toga dubina džepa predstavlja individualnu determinantu. Istovremeno, proces gubitka marginalne kosti predstavlja fiziološku pojavu koja je najintezivnija u prvoj godini opterećenja, i istraživanja su pokazala da iznosi -0.78mm mezijalno i -0.85mm distalno, a zatim se kontinurano odvija i na godišnjem nivou iznosi oko 0.2mm. Pomenuta vrednost iznosi prosečnu vrednost ali ona takođe individualno varira i uslovljena je tipom implantata, dizajnom abatmenta i mnogim drugim faktorima. Iz tog razloga se relativni nivo pripojnog epitela (rCAL) kao ni radiološki evidentan gubitak kosti ne mogu usvojiti kao apsolutni indikatori patološkog gubitka kosti. U dijagnostici stanja peri-implantnih tkiva koristi se nekoliko tipova metoda i najčešće u kombinaciji radi što potpunijeg postavljanja dijagnoze. Dijagnostičke metode uključuju: određivanje kliničkih parametara, radiološke analize, mikrobiološke analize i kvalitativne i kvantitativne analize peri-implantnte krevikularne tečnosti (PICF). Analiza PICF predstavlja jednu od najatraktivnijih metoda u savremenoj implantologiji, pri čemu je njena najveća vrednost u tome što daje direktne informacije o stanju peri-implantinh tkiva i zasnovano na tome poseduje mogućnost da pokaže rane znake oboljenja peri-implantnih tkiva u fazi gde su tkivne promene reverzibilne. Ovo ograničenje kliničkih metoda rezultira u propuštanju vremena od momenta pojave bolesti koje proporcijonalno umanjuje uspeh terapije, a često i u izboru neadekvatnog terapijskog plana. Zasnovano na tome, metoda merenja specifičnih biomarkera u uzorku PICF nadomešćuje ograničenja konvencionalnih kliničkih dijagnostičkih metoda koje daju informacije u stadijumu razvijene bolesti. Brojne studije se sprovode u cilju identifikacije biomolekula koji pouzdano reflektuje stanje peri-implantnih tkiva, ali kako je patologija lokalnog meatbolizma kompleksna, a metoda evaluacije visoko-osetljiva, standardizacija ove metode je još uvek u toku...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Determination of alveolar bone loss biomarkers related to peri-implantitis
T1  - Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom
UR  - https://hdl.handle.net/21.15107/rcub_nardus_2684
ER  - 

@phdthesis{
author = "Rakić, Mia",
year = "2012",
abstract = "Peri-implantitis is inflammatory process characterized by supporting bone loss of loaded oral implants. The pathognomonic characteristic of peri-implantitis is supporting bone loss of the loaded implant. This process is based on inflammatory osteoclastogenesis which simultaneously represent the central pathologic process of the disorder. Inflammatory osteoclastogenesis implies maturation of pre-osteoclasts and enhancement of the activity of maturated osteoclasts which are induced by achieving of the critical concentrations of proinflammatory mediators. Clinical characteristics of the peri-implantitis are still not strictly defined and they vary because in the physiological conditions the values of clinical parameters varies among individuals, for example peri-implant sulcus depth represents the individual determinant which could be from 0.5mm to 4mm as well. Simultaneously, the marginal bone loss is the physiological characteristic around implants in function, which is the most intensive in the first year of loading represented by the -0.78mm in the mesial sites and -0.85mm at the distal sites, and after that the process is constant and bone loss at the year level is approximately 0.2mm. The mentioned value is the average values that individually vary and it depends of the implant type, abutments and numerous other factors. From that reason the relative clinical attachment level (rCAL), nether radiological proof of bone loss could be accepted as the absolute indicators of the pathological bone loss. In the peri-implant diagnostics the most frequently are used the few different diagnostic procedures in the combination to give the complete diagnostic view. These diagnostic methods include: evaluation of clinical parameters, radiological analyses, microbiological analyses and quantitative and qualitative analyses of PICF. The PICF analysis is one of the most attractive methods in current implantology, where the one of the most precious values is providing of the direct information on peri-implant tissues d based on that providing information on early disease onset in the phase of reversible damage. This limitation of clinical methods results in time loss proportionally decreasing treatment success, and frequently resulting in inappropriate treatment planning. Based on that, evaluation of biomarkers in PICF sample compensates limitations of conventional diagnostic procedures without capability to provide accurate information on early disease. Numerous studies have been conducted to identify the biomolecules accurately reflecting peri-implant tissue condition, but since the pathology of local metabolism is complex, the method for evaluation is still under standardization..., Peri-implantitis predstavlja inflamatorni proces koji se karakteriše gubitkom potporne kosti opterećenog oralnog implantata. Osnovna patološka karakteristika peri-implantitisa je gubitak potporne kosti implantata u funkciji. Ovaj proces je zasnovan na inflamatornoj osteoklastogenezi koja ujedno predstavlja centralni patološki proces peri-implantitisa. Inflamatorna osteoklastogeneza predstavlja proces sazrevanja pre-osteoklasta i pojačavanje aktivnosti zrelih osteoklasta pod uticajem kritičnih koncentracija pro-inflamatornih medijatora. Kliničke karakteristike peri-implantitisa nisu strogo definisane i variraju iz prostog razloga jer dubina peri-implantnog sulkusa značajno varira s'toga dubina džepa predstavlja individualnu determinantu. Istovremeno, proces gubitka marginalne kosti predstavlja fiziološku pojavu koja je najintezivnija u prvoj godini opterećenja, i istraživanja su pokazala da iznosi -0.78mm mezijalno i -0.85mm distalno, a zatim se kontinurano odvija i na godišnjem nivou iznosi oko 0.2mm. Pomenuta vrednost iznosi prosečnu vrednost ali ona takođe individualno varira i uslovljena je tipom implantata, dizajnom abatmenta i mnogim drugim faktorima. Iz tog razloga se relativni nivo pripojnog epitela (rCAL) kao ni radiološki evidentan gubitak kosti ne mogu usvojiti kao apsolutni indikatori patološkog gubitka kosti. U dijagnostici stanja peri-implantnih tkiva koristi se nekoliko tipova metoda i najčešće u kombinaciji radi što potpunijeg postavljanja dijagnoze. Dijagnostičke metode uključuju: određivanje kliničkih parametara, radiološke analize, mikrobiološke analize i kvalitativne i kvantitativne analize peri-implantnte krevikularne tečnosti (PICF). Analiza PICF predstavlja jednu od najatraktivnijih metoda u savremenoj implantologiji, pri čemu je njena najveća vrednost u tome što daje direktne informacije o stanju peri-implantinh tkiva i zasnovano na tome poseduje mogućnost da pokaže rane znake oboljenja peri-implantnih tkiva u fazi gde su tkivne promene reverzibilne. Ovo ograničenje kliničkih metoda rezultira u propuštanju vremena od momenta pojave bolesti koje proporcijonalno umanjuje uspeh terapije, a često i u izboru neadekvatnog terapijskog plana. Zasnovano na tome, metoda merenja specifičnih biomarkera u uzorku PICF nadomešćuje ograničenja konvencionalnih kliničkih dijagnostičkih metoda koje daju informacije u stadijumu razvijene bolesti. Brojne studije se sprovode u cilju identifikacije biomolekula koji pouzdano reflektuje stanje peri-implantnih tkiva, ali kako je patologija lokalnog meatbolizma kompleksna, a metoda evaluacije visoko-osetljiva, standardizacija ove metode je još uvek u toku...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Determination of alveolar bone loss biomarkers related to peri-implantitis, Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom",
url = "https://hdl.handle.net/21.15107/rcub_nardus_2684"
}

Rakić, M.. (2012). Determination of alveolar bone loss biomarkers related to peri-implantitis. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_2684

Rakić M. Determination of alveolar bone loss biomarkers related to peri-implantitis. 2012;.
https://hdl.handle.net/21.15107/rcub_nardus_2684 .

Rakić, Mia, "Determination of alveolar bone loss biomarkers related to peri-implantitis" (2012),
https://hdl.handle.net/21.15107/rcub_nardus_2684 .

TY  - THES
AU  - Rakić, Mia
PY  - 2012
UR  - https://plus.sr.cobiss.net/opac7/bib/1024187278
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/522
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom
UR  - https://hdl.handle.net/21.15107/rcub_smile_522
ER  - 

@phdthesis{
author = "Rakić, Mia",
year = "2012",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom",
url = "https://hdl.handle.net/21.15107/rcub_smile_522"
}

Rakić, M.. (2012). Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_522

Rakić M. Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom. 2012;.
https://hdl.handle.net/21.15107/rcub_smile_522 .

Rakić, Mia, "Određivanje biomarkera gubitka alveolarne kosti kod pacijenata sa peri-implantitisom" (2012),
https://hdl.handle.net/21.15107/rcub_smile_522 .

TY  - JOUR
AU  - Rakić, Mia
AU  - Zelić, Ksenija
AU  - Pavlica, Dušan
AU  - Hadži-Mihailović, Miloš
AU  - Milašin, Jelena
AU  - Miličić, Biljana
AU  - Nikolić, Nebojša
AU  - Stamatović, Novak
AU  - Matić, Smiljana
AU  - Aleksić, Zoran
AU  - Janković, Saša
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1543
AB  - Background/Aim. Periodontitis is a chronic inflammatory disease of periodontal tissues with consequential is bone loss as a result of host immunological reactions caused by periopathogens. The aim of the study was to investigate if there is a correlation between clinical parameters and the presence of two most aggressive periopathogens (Aggregatibacter actinomycetemcomitans - Aa and Porphyromonas gingivalis - Pg) in patients with progressive periodontal lesions. Methods. A total of 34 systemic healthy people, 23 to 70 years old, were included in the study. The patients were clinically and radiologically examined, and after that, the representative pocket with greatest pocket depth was chosen and the sample was collected from that place. The measured clinic parameters were: gingival index, index of gingival bleeding, pocket depth and plaque indices. The multiplex Polymerase Chain Reaction (PCR) method was used for detection of periopathogens. After obtaining results, appropriate statistical tests were used to correlate the clinical and microbiological results. Results. Aa and Pg were detected in the same percentage of samples. Aa and Pg were detected in 35.29% samples alone, and in 29.41% both were detected. The values of measured clinical parameters did not show a statistical significance between the groups. In analysis of correlations among clinical parameters inside the groups, a statistical significance was found only between gingival and plaque index in the group with Aa. Conclusion. Clinical course of periodontitis in the developed stage does not differ in relation to the presence of different periopathogens as the major inductors of immunologically guided destructive processes.
AB  - Uvod/Cilj. Parodontopatija je hronično inflamatorno oboljenje parodontalnih tkiva koje za krajnji ishod ima gubitak potpornog koštanog tkiva zuba usled imunoloških reakcija izazvanih parodontopatogenim bakterijama. Cilj studije bio je korelisanje kliničkih parametara i prisustva dve najagresivnije parodontopatogene bakterije (Aggregatibacter actinomycetemcomitans - A.a. i Porphyromonas gingivalis - P.g.) kod bolesnika sa progresivnim parodontalnim lezijama. Metode. U studiju su bila uključena 34 sistemski zdrava ispitanika, starost 23-70 godina. Ispitanici su klinički i radiološki pregledani i uzorak je uziman iz reprezentativnog parodontalnog džepa sa najvećom dubinom sondiranja. Od kliničkih parametara mereni su gingivalni indeks, indeks krvarenja gingive, dubina parodontalnog džepa i indeks plaka. Prisustvo parodontopatogena dokazivano je multipleks metodom PCR (Polymerase Chain Reaction), a rezultati su korelisani sa kliničkim parametrima primenom odgovarajućih statističkih testova. Rezultati. Ista procentualna zastupljenost oba mikroorganizma dokazana je u uzorcima, naime i A.a. i P.g. bili su prisutni u po 35,39% uzoraka, a u 29,41% dokazana su oba mikroorganizma. Rezultati su korelisani po grupama formiranim u odnosu na prisustvo bakterija. Vrednosti merenih kliničkih parametara nisu se statistički značajno razlikovale u zavisnosti od prisustva parodontopatogena. Međusobne korelacije kliničkih parametara unutar grupe nisu pokazale statističku značajnost, osim korelacije gingivalnog i plak indeksa u grupi sa A.a. Zaključak. Klinički tok uznapredovale faze parodontopatije ne razlikuje se u odnosu na vrstu parodontalnih bakterija kao induktora imunološki posredovanih destruktivnih procesa.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions
T1  - Povezanost kliničkih parametara i prisustva Aggregatibacter actinomycetemcomitans i Porphyromonas gingivalis kod pacijenata sa progresivnim parodontalnim lezijama
VL  - 67
IS  - 11
SP  - 898
EP  - 902
DO  - 10.2298/VSP1011898R
ER  - 

@article{
author = "Rakić, Mia and Zelić, Ksenija and Pavlica, Dušan and Hadži-Mihailović, Miloš and Milašin, Jelena and Miličić, Biljana and Nikolić, Nebojša and Stamatović, Novak and Matić, Smiljana and Aleksić, Zoran and Janković, Saša",
year = "2010",
abstract = "Background/Aim. Periodontitis is a chronic inflammatory disease of periodontal tissues with consequential is bone loss as a result of host immunological reactions caused by periopathogens. The aim of the study was to investigate if there is a correlation between clinical parameters and the presence of two most aggressive periopathogens (Aggregatibacter actinomycetemcomitans - Aa and Porphyromonas gingivalis - Pg) in patients with progressive periodontal lesions. Methods. A total of 34 systemic healthy people, 23 to 70 years old, were included in the study. The patients were clinically and radiologically examined, and after that, the representative pocket with greatest pocket depth was chosen and the sample was collected from that place. The measured clinic parameters were: gingival index, index of gingival bleeding, pocket depth and plaque indices. The multiplex Polymerase Chain Reaction (PCR) method was used for detection of periopathogens. After obtaining results, appropriate statistical tests were used to correlate the clinical and microbiological results. Results. Aa and Pg were detected in the same percentage of samples. Aa and Pg were detected in 35.29% samples alone, and in 29.41% both were detected. The values of measured clinical parameters did not show a statistical significance between the groups. In analysis of correlations among clinical parameters inside the groups, a statistical significance was found only between gingival and plaque index in the group with Aa. Conclusion. Clinical course of periodontitis in the developed stage does not differ in relation to the presence of different periopathogens as the major inductors of immunologically guided destructive processes., Uvod/Cilj. Parodontopatija je hronično inflamatorno oboljenje parodontalnih tkiva koje za krajnji ishod ima gubitak potpornog koštanog tkiva zuba usled imunoloških reakcija izazvanih parodontopatogenim bakterijama. Cilj studije bio je korelisanje kliničkih parametara i prisustva dve najagresivnije parodontopatogene bakterije (Aggregatibacter actinomycetemcomitans - A.a. i Porphyromonas gingivalis - P.g.) kod bolesnika sa progresivnim parodontalnim lezijama. Metode. U studiju su bila uključena 34 sistemski zdrava ispitanika, starost 23-70 godina. Ispitanici su klinički i radiološki pregledani i uzorak je uziman iz reprezentativnog parodontalnog džepa sa najvećom dubinom sondiranja. Od kliničkih parametara mereni su gingivalni indeks, indeks krvarenja gingive, dubina parodontalnog džepa i indeks plaka. Prisustvo parodontopatogena dokazivano je multipleks metodom PCR (Polymerase Chain Reaction), a rezultati su korelisani sa kliničkim parametrima primenom odgovarajućih statističkih testova. Rezultati. Ista procentualna zastupljenost oba mikroorganizma dokazana je u uzorcima, naime i A.a. i P.g. bili su prisutni u po 35,39% uzoraka, a u 29,41% dokazana su oba mikroorganizma. Rezultati su korelisani po grupama formiranim u odnosu na prisustvo bakterija. Vrednosti merenih kliničkih parametara nisu se statistički značajno razlikovale u zavisnosti od prisustva parodontopatogena. Međusobne korelacije kliničkih parametara unutar grupe nisu pokazale statističku značajnost, osim korelacije gingivalnog i plak indeksa u grupi sa A.a. Zaključak. Klinički tok uznapredovale faze parodontopatije ne razlikuje se u odnosu na vrstu parodontalnih bakterija kao induktora imunološki posredovanih destruktivnih procesa.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions, Povezanost kliničkih parametara i prisustva Aggregatibacter actinomycetemcomitans i Porphyromonas gingivalis kod pacijenata sa progresivnim parodontalnim lezijama",
volume = "67",
number = "11",
pages = "898-902",
doi = "10.2298/VSP1011898R"
}

Rakić, M., Zelić, K., Pavlica, D., Hadži-Mihailović, M., Milašin, J., Miličić, B., Nikolić, N., Stamatović, N., Matić, S., Aleksić, Z.,& Janković, S.. (2010). Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(11), 898-902.
https://doi.org/10.2298/VSP1011898R

Rakić M, Zelić K, Pavlica D, Hadži-Mihailović M, Milašin J, Miličić B, Nikolić N, Stamatović N, Matić S, Aleksić Z, Janković S. Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions. in Vojnosanitetski pregled. 2010;67(11):898-902.
doi:10.2298/VSP1011898R .

Rakić, Mia, Zelić, Ksenija, Pavlica, Dušan, Hadži-Mihailović, Miloš, Milašin, Jelena, Miličić, Biljana, Nikolić, Nebojša, Stamatović, Novak, Matić, Smiljana, Aleksić, Zoran, Janković, Saša, "Association between clinical parameters and the presence of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis in patients with progressive periodontal lesions" in Vojnosanitetski pregled, 67, no. 11 (2010):898-902,
https://doi.org/10.2298/VSP1011898R . .

TY  - JOUR
AU  - Tatić, Zoran
AU  - Stamatović, Novak
AU  - Bubalo, Marija
AU  - Jančić, Snežana
AU  - Račić, Alek
AU  - Miković, Nikola
AU  - Tatić, Natalija
AU  - Rakić, Mia
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1540
AB  - Background/Aim. Filling a bone defect with bone substitution materials is a therapy of choice, but the infiltration of connective tissue from the mucoperiostal flap may compromise a healing of bone substitutions with bony wall defects. Application of membrane as a barrier is indicated as a solution to this problem. The aim of this study was to show a pathohistological view of bone regeneration and the significance of human resorbable demineralized membrane (HRDM), 200 μ thick in bone regeneration regarding mandibular defects in an experiment on dogs. Methods. The experiment was performed on six dogs. Bone defects were created in all six dogs on the right side of the mandible after the elevation of the mucoperiostal flap. One defect was filled with human deproteinised bone (HDB), and in between HDB and soft tissue RHDM of 200 μ thick was placed. In the second defect, used as a control one, only HDB without RHDM was placed. Two dogs were sacrificed two months after the surgery, another two dogs four months after the surgery and the last two dogs six months after the surgery. After that, samples of bone tissue were taken for histopathological analysis. Results. In all the six dogs with defects treated with HDB and RHDM the level of bone regeneration was much higher in comparison with the control defects without RHDM. Conclusion. Membrane, as a cover of bony defect, is useful and benefits bone regeneration. Bony defects covered with RHDM show better bony healing despite the fact that bone regeneration was not fully complete for as long as six months after the RHDM implantation.
AB  - Uvod/Cilj. Popunjavanje koštanih defekata zamenicima kosti je terapija izbora, ali prorastanje vezivnog tkiva iz mukoperiostalnog režnja može kompromitovati sam proces zarastanja zamenika kosti sa zidovima koštanih defekata. U cilju rešavanja ovog problema indikovana je primena membrane kao barijere. Cilj ove studije bio je da se prikaže patohistološki izgled koštane regeneracije i značaj resorptivne demineralizovane membrane humanog porekla (RHDM), debljine 200 mikrona, u regeneraciji kosti kod mandibularnih defekata u eksperimentu rađenom na psima. Metode. Eksperiment je vršen na šest pasa kojima je sa desne strane donje vilice, po podizanju mukoperiostalnog režnja, pravljen koštani defekt. U jedan defekt stavljana je humana deproteinizovana kost (HDK), a između nje i mekotkivnog dela stavljana je RHDM debljine 200 mikrona. U drugi defekt, koji je služio kao kontrola, stavljena je samo HDK, bez RHDM. Dva psa žrtvovana su dva meseca nakon hirurške intervencije, dva posle četiri meseca, a preostala dva šest meseci nakon hirurške intervencije. Nakon žrtvovanja uzimani su isečci za patohistološku analizu. Rezultati. Kod svih šest pasa kod kojih je u koštani defekt ugrađena HDK i RHDM stepen koštane regeneracije bio je daleko veći u odnosu na kontrolne defekte bez RHDM. Zaključak. Membrana, kao pokrivač koštanog defekta, podesna je i poboljšava koštanu regeneraciju. Koštani defekti prekriveni RHDM pokazali su značajno bolje koštano zarastanje, mada koštana regeneracija nije bila potpuna ni šest meseci nakon njene ugradnje.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Histopathological evaluation of bone regeneration using human resorbable demineralized membrane
T1  - Uticaj resorptivne membrane humanog porekla na regeneraciju koštanog tkiva - patohistološka studija
VL  - 67
IS  - 6
SP  - 480
EP  - 486
DO  - 10.2298/VSP1006480T
ER  - 

@article{
author = "Tatić, Zoran and Stamatović, Novak and Bubalo, Marija and Jančić, Snežana and Račić, Alek and Miković, Nikola and Tatić, Natalija and Rakić, Mia",
year = "2010",
abstract = "Background/Aim. Filling a bone defect with bone substitution materials is a therapy of choice, but the infiltration of connective tissue from the mucoperiostal flap may compromise a healing of bone substitutions with bony wall defects. Application of membrane as a barrier is indicated as a solution to this problem. The aim of this study was to show a pathohistological view of bone regeneration and the significance of human resorbable demineralized membrane (HRDM), 200 μ thick in bone regeneration regarding mandibular defects in an experiment on dogs. Methods. The experiment was performed on six dogs. Bone defects were created in all six dogs on the right side of the mandible after the elevation of the mucoperiostal flap. One defect was filled with human deproteinised bone (HDB), and in between HDB and soft tissue RHDM of 200 μ thick was placed. In the second defect, used as a control one, only HDB without RHDM was placed. Two dogs were sacrificed two months after the surgery, another two dogs four months after the surgery and the last two dogs six months after the surgery. After that, samples of bone tissue were taken for histopathological analysis. Results. In all the six dogs with defects treated with HDB and RHDM the level of bone regeneration was much higher in comparison with the control defects without RHDM. Conclusion. Membrane, as a cover of bony defect, is useful and benefits bone regeneration. Bony defects covered with RHDM show better bony healing despite the fact that bone regeneration was not fully complete for as long as six months after the RHDM implantation., Uvod/Cilj. Popunjavanje koštanih defekata zamenicima kosti je terapija izbora, ali prorastanje vezivnog tkiva iz mukoperiostalnog režnja može kompromitovati sam proces zarastanja zamenika kosti sa zidovima koštanih defekata. U cilju rešavanja ovog problema indikovana je primena membrane kao barijere. Cilj ove studije bio je da se prikaže patohistološki izgled koštane regeneracije i značaj resorptivne demineralizovane membrane humanog porekla (RHDM), debljine 200 mikrona, u regeneraciji kosti kod mandibularnih defekata u eksperimentu rađenom na psima. Metode. Eksperiment je vršen na šest pasa kojima je sa desne strane donje vilice, po podizanju mukoperiostalnog režnja, pravljen koštani defekt. U jedan defekt stavljana je humana deproteinizovana kost (HDK), a između nje i mekotkivnog dela stavljana je RHDM debljine 200 mikrona. U drugi defekt, koji je služio kao kontrola, stavljena je samo HDK, bez RHDM. Dva psa žrtvovana su dva meseca nakon hirurške intervencije, dva posle četiri meseca, a preostala dva šest meseci nakon hirurške intervencije. Nakon žrtvovanja uzimani su isečci za patohistološku analizu. Rezultati. Kod svih šest pasa kod kojih je u koštani defekt ugrađena HDK i RHDM stepen koštane regeneracije bio je daleko veći u odnosu na kontrolne defekte bez RHDM. Zaključak. Membrana, kao pokrivač koštanog defekta, podesna je i poboljšava koštanu regeneraciju. Koštani defekti prekriveni RHDM pokazali su značajno bolje koštano zarastanje, mada koštana regeneracija nije bila potpuna ni šest meseci nakon njene ugradnje.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Histopathological evaluation of bone regeneration using human resorbable demineralized membrane, Uticaj resorptivne membrane humanog porekla na regeneraciju koštanog tkiva - patohistološka studija",
volume = "67",
number = "6",
pages = "480-486",
doi = "10.2298/VSP1006480T"
}

Tatić, Z., Stamatović, N., Bubalo, M., Jančić, S., Račić, A., Miković, N., Tatić, N.,& Rakić, M.. (2010). Histopathological evaluation of bone regeneration using human resorbable demineralized membrane. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(6), 480-486.
https://doi.org/10.2298/VSP1006480T

Tatić Z, Stamatović N, Bubalo M, Jančić S, Račić A, Miković N, Tatić N, Rakić M. Histopathological evaluation of bone regeneration using human resorbable demineralized membrane. in Vojnosanitetski pregled. 2010;67(6):480-486.
doi:10.2298/VSP1006480T .

Tatić, Zoran, Stamatović, Novak, Bubalo, Marija, Jančić, Snežana, Račić, Alek, Miković, Nikola, Tatić, Natalija, Rakić, Mia, "Histopathological evaluation of bone regeneration using human resorbable demineralized membrane" in Vojnosanitetski pregled, 67, no. 6 (2010):480-486,
https://doi.org/10.2298/VSP1006480T . .