TY  - JOUR
AU  - Janović, Aleksa
AU  - Miličić, Biljana
AU  - Antić, Svetlana
AU  - Bracanović, Đurđa
AU  - Marković‑Vasiljković, Biljana
PY  - 2024-01
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3292
AB  - Determination of sarcopenia is crucial in identifying patients at high risk of adverse health outcomes. Recent studies reported a significant decline in masticatory muscle (MM) function in patients with sarcopenia. This study aimed to analyze the cross-sectional area (CSA) of MMs on computed tomography (CT) images and to explore their potential to predict sarcopenia. The study included 149 adult subjects retrospectively (59 males, 90 females, mean age 57.4 ± 14.8 years) who underwent head and neck CT examination for diagnostic purposes. Sarcopenia was diagnosed on CT by measuring CSA of neck muscles at the C3 vertebral level and estimating skeletal muscle index. CSA of MMs (temporal, masseter, medial pterygoid, and lateral pterygoid) were measured bilaterally on reference CT slices. Sarcopenia was diagnosed in 67 (45%) patients. Univariate logistic regression analysis demonstrated a significant association between CSA of all MMs and sarcopenia. In the multivariate logistic regression model, only masseter CSA, lateral pterygoid CSA, age, and gender were marked as predictors of sarcopenia. These parameters were combined in a regression equation, which showed excellent sensitivity and specificity in predicting sarcopenia. The masseter and lateral pterygoid CSA can be used to predict sarcopenia in healthy aging subjects with a high accuracy.
PB  - Springer Nature
T2  - Scientific Reports
T1  - Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects
VL  - 14
SP  - 2079
DO  - 10.1038/s41598-024-51589-4
ER  - 

@article{
author = "Janović, Aleksa and Miličić, Biljana and Antić, Svetlana and Bracanović, Đurđa and Marković‑Vasiljković, Biljana",
year = "2024-01",
abstract = "Determination of sarcopenia is crucial in identifying patients at high risk of adverse health outcomes. Recent studies reported a significant decline in masticatory muscle (MM) function in patients with sarcopenia. This study aimed to analyze the cross-sectional area (CSA) of MMs on computed tomography (CT) images and to explore their potential to predict sarcopenia. The study included 149 adult subjects retrospectively (59 males, 90 females, mean age 57.4 ± 14.8 years) who underwent head and neck CT examination for diagnostic purposes. Sarcopenia was diagnosed on CT by measuring CSA of neck muscles at the C3 vertebral level and estimating skeletal muscle index. CSA of MMs (temporal, masseter, medial pterygoid, and lateral pterygoid) were measured bilaterally on reference CT slices. Sarcopenia was diagnosed in 67 (45%) patients. Univariate logistic regression analysis demonstrated a significant association between CSA of all MMs and sarcopenia. In the multivariate logistic regression model, only masseter CSA, lateral pterygoid CSA, age, and gender were marked as predictors of sarcopenia. These parameters were combined in a regression equation, which showed excellent sensitivity and specificity in predicting sarcopenia. The masseter and lateral pterygoid CSA can be used to predict sarcopenia in healthy aging subjects with a high accuracy.",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects",
volume = "14",
pages = "2079",
doi = "10.1038/s41598-024-51589-4"
}

Janović, A., Miličić, B., Antić, S., Bracanović, Đ.,& Marković‑Vasiljković, B.. (2024-01). Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects. in Scientific Reports
Springer Nature., 14, 2079.
https://doi.org/10.1038/s41598-024-51589-4

Janović A, Miličić B, Antić S, Bracanović Đ, Marković‑Vasiljković B. Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects. in Scientific Reports. 2024;14:2079.
doi:10.1038/s41598-024-51589-4 .

Janović, Aleksa, Miličić, Biljana, Antić, Svetlana, Bracanović, Đurđa, Marković‑Vasiljković, Biljana, "Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects" in Scientific Reports, 14 (2024-01):2079,
https://doi.org/10.1038/s41598-024-51589-4 . .

TY  - JOUR
AU  - Janović, Nataša
AU  - Janović, Aleksa
AU  - Miličić, Biljana
AU  - Đurić, Marija
PY  - 2022
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3293
AB  - Introduction
The impact of the nasal septum morphology on the severity of obstruction symptoms has not been fully explored.

Objective
This study aimed to investigate whether the morphology of the deviated nasal septum assessed by computed tomography may explain nasal obstruction severity.

Methods
The study included 386 patients who were referred to the computed tomography examination of the paranasal sinuses. Patient selection criteria were the absence of facial anomalies, facial trauma, nasal surgery, and sinonasal tumors. Computed tomography images were used to estimate deviated nasal septum prevalence, the prevalence of Mladina's seven types of deviated nasal septum, and to measure the deviated nasal septum angle. Nasal obstruction severity was assessed by the nasal obstruction symptom evaluation, NOSE scale. The relationship between NOSE score, deviated nasal septum morphology, and deviated nasal septum angle was performed by a statistical regression model on the reduced sample of 225 patients.

Results
The prevalence of deviated nasal septum was 92.7%. Type 7 deviated nasal septum was the most frequent (34.2%) followed by type 5 (26.2%) and type 3 (23.6%). The worst NOSE scores were recorded in the type 2 deviated nasal septum (45.00 ± 28.28). The mean deviated nasal septum angle in patients with nasal obstruction was 8.5° ± 3.24. NOSE scores were not significantly associated with deviated nasal septum types and angles.

Conclusion
Patients with different types of deviated nasal septum have different NOSE scores. Computed tomography morphology of the deviated nasal septum could not fully explain the severity of nasal obstruction.
PB  - Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial
T2  - BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
T1  - Relationship between nasal septum morphology and nasal obstruction symptom severity: computed tomography study
VL  - 88
IS  - 5
SP  - 663
EP  - 668
DO  - https://doi.org/10.1016/j.bjorl.2020.09.004
ER  - 

@article{
author = "Janović, Nataša and Janović, Aleksa and Miličić, Biljana and Đurić, Marija",
year = "2022",
abstract = "Introduction
The impact of the nasal septum morphology on the severity of obstruction symptoms has not been fully explored.

Objective
This study aimed to investigate whether the morphology of the deviated nasal septum assessed by computed tomography may explain nasal obstruction severity.

Methods
The study included 386 patients who were referred to the computed tomography examination of the paranasal sinuses. Patient selection criteria were the absence of facial anomalies, facial trauma, nasal surgery, and sinonasal tumors. Computed tomography images were used to estimate deviated nasal septum prevalence, the prevalence of Mladina's seven types of deviated nasal septum, and to measure the deviated nasal septum angle. Nasal obstruction severity was assessed by the nasal obstruction symptom evaluation, NOSE scale. The relationship between NOSE score, deviated nasal septum morphology, and deviated nasal septum angle was performed by a statistical regression model on the reduced sample of 225 patients.

Results
The prevalence of deviated nasal septum was 92.7%. Type 7 deviated nasal septum was the most frequent (34.2%) followed by type 5 (26.2%) and type 3 (23.6%). The worst NOSE scores were recorded in the type 2 deviated nasal septum (45.00 ± 28.28). The mean deviated nasal septum angle in patients with nasal obstruction was 8.5° ± 3.24. NOSE scores were not significantly associated with deviated nasal septum types and angles.

Conclusion
Patients with different types of deviated nasal septum have different NOSE scores. Computed tomography morphology of the deviated nasal septum could not fully explain the severity of nasal obstruction.",
publisher = "Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial",
journal = "BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY",
title = "Relationship between nasal septum morphology and nasal obstruction symptom severity: computed tomography study",
volume = "88",
number = "5",
pages = "663-668",
doi = "https://doi.org/10.1016/j.bjorl.2020.09.004"
}

Janović, N., Janović, A., Miličić, B.,& Đurić, M.. (2022). Relationship between nasal septum morphology and nasal obstruction symptom severity: computed tomography study. in BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial., 88(5), 663-668.
https://doi.org/https://doi.org/10.1016/j.bjorl.2020.09.004

Janović N, Janović A, Miličić B, Đurić M. Relationship between nasal septum morphology and nasal obstruction symptom severity: computed tomography study. in BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY. 2022;88(5):663-668.
doi:https://doi.org/10.1016/j.bjorl.2020.09.004 .

Janović, Nataša, Janović, Aleksa, Miličić, Biljana, Đurić, Marija, "Relationship between nasal septum morphology and nasal obstruction symptom severity: computed tomography study" in BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, 88, no. 5 (2022):663-668,
https://doi.org/https://doi.org/10.1016/j.bjorl.2020.09.004 . .

TY  - JOUR
AU  - Janović, Nataša
AU  - Janović, Aleksa
AU  - Miličić, Biljana
AU  - Đurić, Marija
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3294
AB  - Third-party payers request objective confirmation of the nasal septum deviation (NSD) severity by computed tomography (CT) before authorizing financial support for septoplasty. Previous studies have provided contradictory results related to the link between obstruction severity and CT-measured angle of the NSD. The aim of this study was to investigate whether the diverse CT morphology of NSDs (including previously neglected types and shapes) could predict obstruction severity. The study included 225 patients with NSD. The CT morphology of the septum was analyzed using 5 different classifications of NSD that are commonly used in the clinical practice and research. The angle of NSD was also measured. Nasal obstruction was assessed by the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire. A relationship between CT morphology and the angle of the NSD and NOSE scores was analyzed using appropriate regression models. Patients with NSDs located in the anterior part of the septum always have some degree of nasal obstruction, while those with posterior NSDs did not necessarily report obstruction symptoms no matter how complicated NSD they have. Regression analysis did not reveal any causal relationship between NOSE scores and CT morphology and the angle of NSD. The presence of spurs and whether they divide nasal passages have no statistically significant predictive effect on the obstruction severity. The CT morphology and the angle of the NSD could not predict severity of the nasal obstruction. Requesting CT examination just to objectively confirm nasal obstruction is not justified.
PB  - SAGE
T2  - Ear, Nose & Throat Journal
T1  - Is Computed Tomography Imaging of Deviated Nasal Septum Justified for Obstruction Confirmation?
VL  - 100
IS  - 2
SP  - 131
EP  - 136
DO  - https://doi.org/10.1177/0145561319871533
ER  - 

@article{
author = "Janović, Nataša and Janović, Aleksa and Miličić, Biljana and Đurić, Marija",
year = "2021",
abstract = "Third-party payers request objective confirmation of the nasal septum deviation (NSD) severity by computed tomography (CT) before authorizing financial support for septoplasty. Previous studies have provided contradictory results related to the link between obstruction severity and CT-measured angle of the NSD. The aim of this study was to investigate whether the diverse CT morphology of NSDs (including previously neglected types and shapes) could predict obstruction severity. The study included 225 patients with NSD. The CT morphology of the septum was analyzed using 5 different classifications of NSD that are commonly used in the clinical practice and research. The angle of NSD was also measured. Nasal obstruction was assessed by the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire. A relationship between CT morphology and the angle of the NSD and NOSE scores was analyzed using appropriate regression models. Patients with NSDs located in the anterior part of the septum always have some degree of nasal obstruction, while those with posterior NSDs did not necessarily report obstruction symptoms no matter how complicated NSD they have. Regression analysis did not reveal any causal relationship between NOSE scores and CT morphology and the angle of NSD. The presence of spurs and whether they divide nasal passages have no statistically significant predictive effect on the obstruction severity. The CT morphology and the angle of the NSD could not predict severity of the nasal obstruction. Requesting CT examination just to objectively confirm nasal obstruction is not justified.",
publisher = "SAGE",
journal = "Ear, Nose & Throat Journal",
title = "Is Computed Tomography Imaging of Deviated Nasal Septum Justified for Obstruction Confirmation?",
volume = "100",
number = "2",
pages = "131-136",
doi = "https://doi.org/10.1177/0145561319871533"
}

Janović, N., Janović, A., Miličić, B.,& Đurić, M.. (2021). Is Computed Tomography Imaging of Deviated Nasal Septum Justified for Obstruction Confirmation?. in Ear, Nose & Throat Journal
SAGE., 100(2), 131-136.
https://doi.org/https://doi.org/10.1177/0145561319871533

Janović N, Janović A, Miličić B, Đurić M. Is Computed Tomography Imaging of Deviated Nasal Septum Justified for Obstruction Confirmation?. in Ear, Nose & Throat Journal. 2021;100(2):131-136.
doi:https://doi.org/10.1177/0145561319871533 .

Janović, Nataša, Janović, Aleksa, Miličić, Biljana, Đurić, Marija, "Is Computed Tomography Imaging of Deviated Nasal Septum Justified for Obstruction Confirmation?" in Ear, Nose & Throat Journal, 100, no. 2 (2021):131-136,
https://doi.org/https://doi.org/10.1177/0145561319871533 . .

TY  - JOUR
AU  - Dragović, Miroslav
AU  - Pejović, Marko
AU  - Stepić, Jelena
AU  - Čolić, Snježana
AU  - Dožić, Branko
AU  - Dragović, Svetlana
AU  - Lazarević, Miloš
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
AU  - Miličić, Biljana
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2513
AB  - Objectives Sutures are the most frequently used medical device for wound closure. They support tissue during the early phase of healing until it regains enough tensile strength. The aim of this study was to compare four different suture materials in terms of the influence on wound healing, microbial adherence, tissue reaction, and relevant clinical parameters which determine their clinical value. Materials and Methods Total number of 32 patients undergoing surgical extraction of four impacted third molars were involved in the study. Clinical parameters were estimated intraoperatively and during the control check-ups. Soft tissue healing around sutures were evaluated on the 3rd and 7th day postoperatively. Microbial colonization was assessed by means of qPCR. Also, histological analysis was done to assess inflammatory reaction. Results Significantly better soft tissue healing was found around monofilament and synthetic sutures compared to multifilament and natural ones respectively. Soft tissue healing was significantly better around all sutures on the 7th day than on the 3rd day postoperatively. Conclusions Non-resorbable polypropylene suture showed superior clinical characteristics among all sutures. Moreover, the best healing of soft tissue and the least inflammatory reaction was found around this thread. The poorest soft tissue healing was found around non-resorbable silk suture. This suture elicited strongest inflammatory reaction and showed the greatest microbial adherence affinity compared to alternative sutures.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Comparison of four different suture materials in respect to oral wound healing, microbial colonization, tissue reaction and clinical features-randomized clinical study
VL  - 24
IS  - 4
SP  - 1527
EP  - 1541
DO  - 10.1007/s00784-019-03034-4
ER  - 

@article{
author = "Dragović, Miroslav and Pejović, Marko and Stepić, Jelena and Čolić, Snježana and Dožić, Branko and Dragović, Svetlana and Lazarević, Miloš and Nikolić, Nadja and Milašin, Jelena and Miličić, Biljana",
year = "2020",
abstract = "Objectives Sutures are the most frequently used medical device for wound closure. They support tissue during the early phase of healing until it regains enough tensile strength. The aim of this study was to compare four different suture materials in terms of the influence on wound healing, microbial adherence, tissue reaction, and relevant clinical parameters which determine their clinical value. Materials and Methods Total number of 32 patients undergoing surgical extraction of four impacted third molars were involved in the study. Clinical parameters were estimated intraoperatively and during the control check-ups. Soft tissue healing around sutures were evaluated on the 3rd and 7th day postoperatively. Microbial colonization was assessed by means of qPCR. Also, histological analysis was done to assess inflammatory reaction. Results Significantly better soft tissue healing was found around monofilament and synthetic sutures compared to multifilament and natural ones respectively. Soft tissue healing was significantly better around all sutures on the 7th day than on the 3rd day postoperatively. Conclusions Non-resorbable polypropylene suture showed superior clinical characteristics among all sutures. Moreover, the best healing of soft tissue and the least inflammatory reaction was found around this thread. The poorest soft tissue healing was found around non-resorbable silk suture. This suture elicited strongest inflammatory reaction and showed the greatest microbial adherence affinity compared to alternative sutures.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Comparison of four different suture materials in respect to oral wound healing, microbial colonization, tissue reaction and clinical features-randomized clinical study",
volume = "24",
number = "4",
pages = "1527-1541",
doi = "10.1007/s00784-019-03034-4"
}

Dragović, M., Pejović, M., Stepić, J., Čolić, S., Dožić, B., Dragović, S., Lazarević, M., Nikolić, N., Milašin, J.,& Miličić, B.. (2020). Comparison of four different suture materials in respect to oral wound healing, microbial colonization, tissue reaction and clinical features-randomized clinical study. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 24(4), 1527-1541.
https://doi.org/10.1007/s00784-019-03034-4

Dragović M, Pejović M, Stepić J, Čolić S, Dožić B, Dragović S, Lazarević M, Nikolić N, Milašin J, Miličić B. Comparison of four different suture materials in respect to oral wound healing, microbial colonization, tissue reaction and clinical features-randomized clinical study. in Clinical Oral Investigations. 2020;24(4):1527-1541.
doi:10.1007/s00784-019-03034-4 .

Dragović, Miroslav, Pejović, Marko, Stepić, Jelena, Čolić, Snježana, Dožić, Branko, Dragović, Svetlana, Lazarević, Miloš, Nikolić, Nadja, Milašin, Jelena, Miličić, Biljana, "Comparison of four different suture materials in respect to oral wound healing, microbial colonization, tissue reaction and clinical features-randomized clinical study" in Clinical Oral Investigations, 24, no. 4 (2020):1527-1541,
https://doi.org/10.1007/s00784-019-03034-4 . .

TY  - JOUR
AU  - Matić Petrović, Sanja
AU  - Nikolić, Nadja
AU  - Toljić, Boško
AU  - Arambašić-Jovanović, Jelena
AU  - Miličić, Biljana
AU  - Miličić, Tanja
AU  - Jotić, Aleksandra
AU  - Vidaković, Melita
AU  - Milašin, Jelena
AU  - Pucar, Ana
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2571
AB  - Objectives: Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 (TNFR2) single nucleotide polymorphisms (SNPs) and: risk of PD or PD + T2D; periodontitis parameters in PD and PD + T2D; serum levels of cytokines/their receptors. Relationship between periodontal inflammation and serum cytokine/receptor levels was also assessed.

Design: Subjects were stratified as: 57 healthy controls (HC); 58 PD; 65 PD + T2D. Sociodemographic, environmental, behavioral and periodontal clinical data were recorded. SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism, while cytokines/receptors levels were quantified by enzyme-linked immunosorbent assay. Impact of periodontal inflammation was measured using periodontal inflamed surface area (PISA).

Results: TNFα AA genotype showed protective effect in T2D + PD compared to PD, even adjusted for behavioral/environmental factors (OR 0.18; 95 %CI 0.037-0.886; p = 0.035). LTα AG heterozygotes had increased risk of PD (OR 3.27; 95 %CI 1.35-7.96; p = 0.016), while TNFR2 TG genotype had protective effect (OR = 0.44; 95 %CI 0.954-0.9794; p = 0.043). TNFR1 AA was predictor of periodontal pocket depth and clinical attachment loss in PD. Correlation between TNFR2 concentration and PISA was negative in PD, positive in PD + T2D.

Conclusions: None of the SNPs showed cross-susceptibility between PD and T2D. + 252A/G LTα and +676 T/G TNFR2 SNPs are associated with PD risk. Periodontal destruction in healthy individuals is influenced by TNFR1 genotype. Impact of periodontal on systemic inflammation is masked by T2D.
PB  - Elsevier Inc.
T2  - Archives of Oral Biology
T1  - The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population
VL  - 120
SP  - 104929
DO  - 10.1016/j.archoralbio.2020.104929
ER  - 

@article{
author = "Matić Petrović, Sanja and Nikolić, Nadja and Toljić, Boško and Arambašić-Jovanović, Jelena and Miličić, Biljana and Miličić, Tanja and Jotić, Aleksandra and Vidaković, Melita and Milašin, Jelena and Pucar, Ana",
year = "2020",
abstract = "Objectives: Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 (TNFR2) single nucleotide polymorphisms (SNPs) and: risk of PD or PD + T2D; periodontitis parameters in PD and PD + T2D; serum levels of cytokines/their receptors. Relationship between periodontal inflammation and serum cytokine/receptor levels was also assessed.

Design: Subjects were stratified as: 57 healthy controls (HC); 58 PD; 65 PD + T2D. Sociodemographic, environmental, behavioral and periodontal clinical data were recorded. SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism, while cytokines/receptors levels were quantified by enzyme-linked immunosorbent assay. Impact of periodontal inflammation was measured using periodontal inflamed surface area (PISA).

Results: TNFα AA genotype showed protective effect in T2D + PD compared to PD, even adjusted for behavioral/environmental factors (OR 0.18; 95 %CI 0.037-0.886; p = 0.035). LTα AG heterozygotes had increased risk of PD (OR 3.27; 95 %CI 1.35-7.96; p = 0.016), while TNFR2 TG genotype had protective effect (OR = 0.44; 95 %CI 0.954-0.9794; p = 0.043). TNFR1 AA was predictor of periodontal pocket depth and clinical attachment loss in PD. Correlation between TNFR2 concentration and PISA was negative in PD, positive in PD + T2D.

Conclusions: None of the SNPs showed cross-susceptibility between PD and T2D. + 252A/G LTα and +676 T/G TNFR2 SNPs are associated with PD risk. Periodontal destruction in healthy individuals is influenced by TNFR1 genotype. Impact of periodontal on systemic inflammation is masked by T2D.",
publisher = "Elsevier Inc.",
journal = "Archives of Oral Biology",
title = "The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population",
volume = "120",
pages = "104929",
doi = "10.1016/j.archoralbio.2020.104929"
}

Matić Petrović, S., Nikolić, N., Toljić, B., Arambašić-Jovanović, J., Miličić, B., Miličić, T., Jotić, A., Vidaković, M., Milašin, J.,& Pucar, A.. (2020). The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. in Archives of Oral Biology
Elsevier Inc.., 120, 104929.
https://doi.org/10.1016/j.archoralbio.2020.104929

Matić Petrović S, Nikolić N, Toljić B, Arambašić-Jovanović J, Miličić B, Miličić T, Jotić A, Vidaković M, Milašin J, Pucar A. The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population. in Archives of Oral Biology. 2020;120:104929.
doi:10.1016/j.archoralbio.2020.104929 .

Matić Petrović, Sanja, Nikolić, Nadja, Toljić, Boško, Arambašić-Jovanović, Jelena, Miličić, Biljana, Miličić, Tanja, Jotić, Aleksandra, Vidaković, Melita, Milašin, Jelena, Pucar, Ana, "The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population" in Archives of Oral Biology, 120 (2020):104929,
https://doi.org/10.1016/j.archoralbio.2020.104929 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2570
AB  - Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386.e8
DO  - 10.1016/j.joen.2020.07.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386.e8",
doi = "10.1016/j.joen.2020.07.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.e8.
https://doi.org/10.1016/j.joen.2020.07.007

Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.e8.
doi:10.1016/j.joen.2020.07.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386.e8,
https://doi.org/10.1016/j.joen.2020.07.007 . .

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2531
AB  - Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386
DO  - 10.1016/j.joen.2020.07.007
ER  - 

@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386",
doi = "10.1016/j.joen.2020.07.007"
}

Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.
https://doi.org/10.1016/j.joen.2020.07.007

Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.
doi:10.1016/j.joen.2020.07.007 .

Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386,
https://doi.org/10.1016/j.joen.2020.07.007 . .

TY  - JOUR
AU  - Milić-Lemić, Aleksandra
AU  - Sredojević, Stefan
AU  - Radović, Katarina
AU  - Stamenković, Dejan
AU  - Miličić, Biljana
AU  - Popovac, Aleksandra
AU  - Stančić, Ivica
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2534
AB  - Introduction/Objective. Recently, new materials for double crowns have been introduced, such as zirconia and polyether ether ketone (PEEK). However, some characteristics of these materials, such as retentive force and duration of “settling in phase,” have not been investigated sufficiently. During the “settling in phase,” telescopic overdenture has not yet achieved its definitive retention force, and it can be harmful for periodontal tissue if the value is above optimal for a long period of time. The objective was to measure the in vitro overall pull-off force of telescopic crowns where primary crowns were made from zirconia ceramics and a survey of the “settling in phase” duration. Methods. Forty zirconia primary telescopic crowns were produced on prepared canine teeth. Twenty secondary crowns were of PEEK and other 20 of zirconia with electroplated gold copings. The pull-off force measurements were conducted utilizing a dynamometer until a constant value was obtained. Results. The specimens of the PEEK group showed higher initial retentive force values. Settling in phase was finished between 800 and 900 cycles of separation for both groups. Comparing the value of the pull-off force between individual different cycles, a statistically significant reduction was recorded up to the 800th cycle, while between the 800th and the 900th cycle there was no difference. Conclusions. The settling in phase was finished between 800 and 900 cycles of separation in both groups. Final retentive force values for both tested telescopic groups were in the optimal range which is 5–9 N per one telescopic crown.
AB  - Uvod/Cilj Poslednjih godina uvedeni su u praksu novi materijali za dvostruke krune, kao što su cirkonija i polietereterketon (PEEK). Međutim, neke karakteristike ovih materijala nisu dovoljno ispitane, kao što su retenciona sila i trajanje "faze uhodavanja". "Faza uhodavanja" je inicijalni period upotrebe teleskopske proteze kada finalna retenciona sila još uvek nije postignuta, i može imati štetni uticaj na parodontalno tkivo ako su u tom periodu sile previsoke i predugo traju. Cilj je bio da se izmeri in vitro ukupna sila razdvajanja teleskopskih kruna, gde su primarne krune izrađene od cirkonijumske keramike, i ispitati trajanje faze uhodavanja. Metode Četrdeset primarnih teleskopskih kruna od cirkonijumske keramike je izrađeno na preparisanim očnjacima. Dvadeset sekundarnih kruna je izrađeno od PEEK-a, i još 20 kruna od cirkonije sa galvanizovanim zlatom. Za merenje sile razdvajanja korišćen je dinamometar. Spajanje i razdvajanje teleskopskih kruna i merenje sile razdvajanja je vršeno dok nije dobijena konstantna vrednost. Rezultati Uzorci iz grupe PEEK pokazali su višu inicijalnu vrednost retencione sile. Faza uhodavanja je završena između 800 i 900 ciklusa razdvajanja kod obe grupe. Kada se uporede individualne vrednosti sile razdvajanja između različitih ciklusa, statistički značajno smanjenje je zabeleženo do 800. ciklusa, dok između 800. i 900. ciklusa nije bilo razlike. Zaključak Faza uhodavanja je završena između 800 i 900 ciklusa razdvajanja u obe grupe. Finalna retenciona sila kod obe testirane grupe pokazala je optimalne vrednosti, koje iznose 5-9 N po teleskopskoj kruni.
PB  - Beograd : Srpsko lekarsko društvo
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Retention force of overdenture retained with telescopic crowns – a comparison of polyether ether ketone and zirconia ceramic telescopic crowns
T1  - Retenciona sila proteze retinirane teleskopskim krunama – poređenje teleskopskih kruna od polieterketona i cirkonijumske keramike
VL  - 148
IS  - 7-8
SP  - 410
EP  - 416
DO  - 10.2298/SARH190923025M
ER  - 

@article{
author = "Milić-Lemić, Aleksandra and Sredojević, Stefan and Radović, Katarina and Stamenković, Dejan and Miličić, Biljana and Popovac, Aleksandra and Stančić, Ivica",
year = "2020",
abstract = "Introduction/Objective. Recently, new materials for double crowns have been introduced, such as zirconia and polyether ether ketone (PEEK). However, some characteristics of these materials, such as retentive force and duration of “settling in phase,” have not been investigated sufficiently. During the “settling in phase,” telescopic overdenture has not yet achieved its definitive retention force, and it can be harmful for periodontal tissue if the value is above optimal for a long period of time. The objective was to measure the in vitro overall pull-off force of telescopic crowns where primary crowns were made from zirconia ceramics and a survey of the “settling in phase” duration. Methods. Forty zirconia primary telescopic crowns were produced on prepared canine teeth. Twenty secondary crowns were of PEEK and other 20 of zirconia with electroplated gold copings. The pull-off force measurements were conducted utilizing a dynamometer until a constant value was obtained. Results. The specimens of the PEEK group showed higher initial retentive force values. Settling in phase was finished between 800 and 900 cycles of separation for both groups. Comparing the value of the pull-off force between individual different cycles, a statistically significant reduction was recorded up to the 800th cycle, while between the 800th and the 900th cycle there was no difference. Conclusions. The settling in phase was finished between 800 and 900 cycles of separation in both groups. Final retentive force values for both tested telescopic groups were in the optimal range which is 5–9 N per one telescopic crown., Uvod/Cilj Poslednjih godina uvedeni su u praksu novi materijali za dvostruke krune, kao što su cirkonija i polietereterketon (PEEK). Međutim, neke karakteristike ovih materijala nisu dovoljno ispitane, kao što su retenciona sila i trajanje "faze uhodavanja". "Faza uhodavanja" je inicijalni period upotrebe teleskopske proteze kada finalna retenciona sila još uvek nije postignuta, i može imati štetni uticaj na parodontalno tkivo ako su u tom periodu sile previsoke i predugo traju. Cilj je bio da se izmeri in vitro ukupna sila razdvajanja teleskopskih kruna, gde su primarne krune izrađene od cirkonijumske keramike, i ispitati trajanje faze uhodavanja. Metode Četrdeset primarnih teleskopskih kruna od cirkonijumske keramike je izrađeno na preparisanim očnjacima. Dvadeset sekundarnih kruna je izrađeno od PEEK-a, i još 20 kruna od cirkonije sa galvanizovanim zlatom. Za merenje sile razdvajanja korišćen je dinamometar. Spajanje i razdvajanje teleskopskih kruna i merenje sile razdvajanja je vršeno dok nije dobijena konstantna vrednost. Rezultati Uzorci iz grupe PEEK pokazali su višu inicijalnu vrednost retencione sile. Faza uhodavanja je završena između 800 i 900 ciklusa razdvajanja kod obe grupe. Kada se uporede individualne vrednosti sile razdvajanja između različitih ciklusa, statistički značajno smanjenje je zabeleženo do 800. ciklusa, dok između 800. i 900. ciklusa nije bilo razlike. Zaključak Faza uhodavanja je završena između 800 i 900 ciklusa razdvajanja u obe grupe. Finalna retenciona sila kod obe testirane grupe pokazala je optimalne vrednosti, koje iznose 5-9 N po teleskopskoj kruni.",
publisher = "Beograd : Srpsko lekarsko društvo",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Retention force of overdenture retained with telescopic crowns – a comparison of polyether ether ketone and zirconia ceramic telescopic crowns, Retenciona sila proteze retinirane teleskopskim krunama – poređenje teleskopskih kruna od polieterketona i cirkonijumske keramike",
volume = "148",
number = "7-8",
pages = "410-416",
doi = "10.2298/SARH190923025M"
}

Milić-Lemić, A., Sredojević, S., Radović, K., Stamenković, D., Miličić, B., Popovac, A.,& Stančić, I.. (2020). Retention force of overdenture retained with telescopic crowns – a comparison of polyether ether ketone and zirconia ceramic telescopic crowns. in Srpski arhiv za celokupno lekarstvo
Beograd : Srpsko lekarsko društvo., 148(7-8), 410-416.
https://doi.org/10.2298/SARH190923025M

Milić-Lemić A, Sredojević S, Radović K, Stamenković D, Miličić B, Popovac A, Stančić I. Retention force of overdenture retained with telescopic crowns – a comparison of polyether ether ketone and zirconia ceramic telescopic crowns. in Srpski arhiv za celokupno lekarstvo. 2020;148(7-8):410-416.
doi:10.2298/SARH190923025M .

Milić-Lemić, Aleksandra, Sredojević, Stefan, Radović, Katarina, Stamenković, Dejan, Miličić, Biljana, Popovac, Aleksandra, Stančić, Ivica, "Retention force of overdenture retained with telescopic crowns – a comparison of polyether ether ketone and zirconia ceramic telescopic crowns" in Srpski arhiv za celokupno lekarstvo, 148, no. 7-8 (2020):410-416,
https://doi.org/10.2298/SARH190923025M . .

TY  - JOUR
AU  - Radosavljević, Katarina
AU  - Dragović-Lukić, Gordana
AU  - Nikolić, Dejan
AU  - Radović, Pavle
AU  - Miličić, Biljana
AU  - Radosavljević, Natasa
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2511
AB  - The study aim was to evaluate the effects of presence and level of musculoskeletal impairment along with gender on physical functioning outcome after the rehabilitation program in aged adults with a hip fracture. We analyzed 203 elderly people with hip fractures above 65 years of age that were treated after the hip surgery. According to the time of examination, patients were tested three times: at admission, discharge, and at three months post-discharge. Musculoskeletal impairments were analyzed, and for the estimation of severity of degree impairment, we used a cumulative index rating scale for geriatrics (CIRS-G). Regarding the gender, we separately analyzed males and females. To evaluate physical functioning of aged adults after a hip fracture, we used the physical functioning component (PFC) from the quality of life (SF-36) questionnaire. For males, on all three occasions we found non-significant differences were found in SF-36 PFC values between different degrees of CIRS-G musculoskeletal impairment. A significant difference was noticed in females three months post-discharge. Effects size of different examination periods for every CIRS-G severity degree of musculoskeletal impairment were high, where males had higher values for severity degrees 1 and 2, and females had higher values for severity degrees 0 and 3. Our findings might suggest that there is a certain degree of different rehabilitation treatment effects for males versus females. Moreover, it might be assumed that other factors could influence different degrees of functional improvement and outcome of individuals after a hip fracture with musculoskeletal impairment.
PB  - Mdpi, Basel
T2  - Healthcare
T1  - Gender and Musculoskeletal Comorbidity Impact on Physical Functioning in Elderly after Hip Fracture: The Role of Rehabilitation
VL  - 8
IS  - 1
DO  - 10.3390/healthcare8010031
ER  - 

@article{
author = "Radosavljević, Katarina and Dragović-Lukić, Gordana and Nikolić, Dejan and Radović, Pavle and Miličić, Biljana and Radosavljević, Natasa",
year = "2020",
abstract = "The study aim was to evaluate the effects of presence and level of musculoskeletal impairment along with gender on physical functioning outcome after the rehabilitation program in aged adults with a hip fracture. We analyzed 203 elderly people with hip fractures above 65 years of age that were treated after the hip surgery. According to the time of examination, patients were tested three times: at admission, discharge, and at three months post-discharge. Musculoskeletal impairments were analyzed, and for the estimation of severity of degree impairment, we used a cumulative index rating scale for geriatrics (CIRS-G). Regarding the gender, we separately analyzed males and females. To evaluate physical functioning of aged adults after a hip fracture, we used the physical functioning component (PFC) from the quality of life (SF-36) questionnaire. For males, on all three occasions we found non-significant differences were found in SF-36 PFC values between different degrees of CIRS-G musculoskeletal impairment. A significant difference was noticed in females three months post-discharge. Effects size of different examination periods for every CIRS-G severity degree of musculoskeletal impairment were high, where males had higher values for severity degrees 1 and 2, and females had higher values for severity degrees 0 and 3. Our findings might suggest that there is a certain degree of different rehabilitation treatment effects for males versus females. Moreover, it might be assumed that other factors could influence different degrees of functional improvement and outcome of individuals after a hip fracture with musculoskeletal impairment.",
publisher = "Mdpi, Basel",
journal = "Healthcare",
title = "Gender and Musculoskeletal Comorbidity Impact on Physical Functioning in Elderly after Hip Fracture: The Role of Rehabilitation",
volume = "8",
number = "1",
doi = "10.3390/healthcare8010031"
}

Radosavljević, K., Dragović-Lukić, G., Nikolić, D., Radović, P., Miličić, B.,& Radosavljević, N.. (2020). Gender and Musculoskeletal Comorbidity Impact on Physical Functioning in Elderly after Hip Fracture: The Role of Rehabilitation. in Healthcare
Mdpi, Basel., 8(1).
https://doi.org/10.3390/healthcare8010031

Radosavljević K, Dragović-Lukić G, Nikolić D, Radović P, Miličić B, Radosavljević N. Gender and Musculoskeletal Comorbidity Impact on Physical Functioning in Elderly after Hip Fracture: The Role of Rehabilitation. in Healthcare. 2020;8(1).
doi:10.3390/healthcare8010031 .

Radosavljević, Katarina, Dragović-Lukić, Gordana, Nikolić, Dejan, Radović, Pavle, Miličić, Biljana, Radosavljević, Natasa, "Gender and Musculoskeletal Comorbidity Impact on Physical Functioning in Elderly after Hip Fracture: The Role of Rehabilitation" in Healthcare, 8, no. 1 (2020),
https://doi.org/10.3390/healthcare8010031 . .

TY  - JOUR
AU  - Vlatkovic Jakovljević, Ivana
AU  - Todorović, Aleksandar
AU  - Budak, Igor
AU  - Sokac, Mario
AU  - Miličić, Biljana
AU  - Špadijer-Gostović, Aleksandra
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2516
AB  - The purpose of the study was to test new method for in vitro evaluation of dental material wear with 3D digitization procedure. Thirty dental crowns, made of polyetheretherketone and veneered with composite material, were subjected to wear test. The crown surface was digitized using coordinate measuring machine before and after the performed wear test. Mesh 3D models were reconstructed and average and maximum depth of lost material and volume loss was calculated (GOM Inspect 2016 software). Mean average depth value amounted 12 7 gm, maximum depth value was 42 gm, while mean volume loss was 0.0024 mm(3). The smallest measured values were 4 gm for depth value and 0.0003 mm(3) for volume loss. Coefficient of variation was very high for all tested parameters (>50%) as a result of data inconsistency. Within the limitations of applied methodology, the possibility of using coordinate measuring machine in measurement of dental material wear was confirmed.
PB  - Japanese Soc Dental Materials Devices, Tokyo
T2  - Dental Materials Journal
T1  - Measurement of dental crown wear-In vitro study
VL  - 39
IS  - 1
SP  - 126
EP  - 134
DO  - 10.4012/dmj.2018-280
ER  - 

@article{
author = "Vlatkovic Jakovljević, Ivana and Todorović, Aleksandar and Budak, Igor and Sokac, Mario and Miličić, Biljana and Špadijer-Gostović, Aleksandra",
year = "2020",
abstract = "The purpose of the study was to test new method for in vitro evaluation of dental material wear with 3D digitization procedure. Thirty dental crowns, made of polyetheretherketone and veneered with composite material, were subjected to wear test. The crown surface was digitized using coordinate measuring machine before and after the performed wear test. Mesh 3D models were reconstructed and average and maximum depth of lost material and volume loss was calculated (GOM Inspect 2016 software). Mean average depth value amounted 12 7 gm, maximum depth value was 42 gm, while mean volume loss was 0.0024 mm(3). The smallest measured values were 4 gm for depth value and 0.0003 mm(3) for volume loss. Coefficient of variation was very high for all tested parameters (>50%) as a result of data inconsistency. Within the limitations of applied methodology, the possibility of using coordinate measuring machine in measurement of dental material wear was confirmed.",
publisher = "Japanese Soc Dental Materials Devices, Tokyo",
journal = "Dental Materials Journal",
title = "Measurement of dental crown wear-In vitro study",
volume = "39",
number = "1",
pages = "126-134",
doi = "10.4012/dmj.2018-280"
}

Vlatkovic Jakovljević, I., Todorović, A., Budak, I., Sokac, M., Miličić, B.,& Špadijer-Gostović, A.. (2020). Measurement of dental crown wear-In vitro study. in Dental Materials Journal
Japanese Soc Dental Materials Devices, Tokyo., 39(1), 126-134.
https://doi.org/10.4012/dmj.2018-280

Vlatkovic Jakovljević I, Todorović A, Budak I, Sokac M, Miličić B, Špadijer-Gostović A. Measurement of dental crown wear-In vitro study. in Dental Materials Journal. 2020;39(1):126-134.
doi:10.4012/dmj.2018-280 .

Vlatkovic Jakovljević, Ivana, Todorović, Aleksandar, Budak, Igor, Sokac, Mario, Miličić, Biljana, Špadijer-Gostović, Aleksandra, "Measurement of dental crown wear-In vitro study" in Dental Materials Journal, 39, no. 1 (2020):126-134,
https://doi.org/10.4012/dmj.2018-280 . .

TY  - JOUR
AU  - Dragašević, Sanja
AU  - Sokić-Milutinović, Aleksandra
AU  - Stojković-Lalošević, Milica
AU  - Milovanović, Tamara
AU  - Đuranović, Srđan
AU  - Jovanović, Ivan
AU  - Rajić, Sanja
AU  - Stojković, Mirjana
AU  - Miličić, Biljana
AU  - Kmezić, Stefan
AU  - Oluić, Branislav
AU  - Aleksić, Marko
AU  - Pavlović-Marković, Aleksandra
AU  - Popović, Dragan
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2507
AB  - Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.
PB  - Hindawi Ltd, London
T2  - Gastroenterology Research & Practice
T1  - Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients
VL  - 2020
DO  - 10.1155/2020/2065383
ER  - 

@article{
author = "Dragašević, Sanja and Sokić-Milutinović, Aleksandra and Stojković-Lalošević, Milica and Milovanović, Tamara and Đuranović, Srđan and Jovanović, Ivan and Rajić, Sanja and Stojković, Mirjana and Miličić, Biljana and Kmezić, Stefan and Oluić, Branislav and Aleksić, Marko and Pavlović-Marković, Aleksandra and Popović, Dragan",
year = "2020",
abstract = "Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients' reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn's disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn's disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn's disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn's disease (rs=-0.67; rs=-0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn's disease.",
publisher = "Hindawi Ltd, London",
journal = "Gastroenterology Research & Practice",
title = "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients",
volume = "2020",
doi = "10.1155/2020/2065383"
}

Dragašević, S., Sokić-Milutinović, A., Stojković-Lalošević, M., Milovanović, T., Đuranović, S., Jovanović, I., Rajić, S., Stojković, M., Miličić, B., Kmezić, S., Oluić, B., Aleksić, M., Pavlović-Marković, A.,& Popović, D.. (2020). Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice
Hindawi Ltd, London., 2020.
https://doi.org/10.1155/2020/2065383

Dragašević S, Sokić-Milutinović A, Stojković-Lalošević M, Milovanović T, Đuranović S, Jovanović I, Rajić S, Stojković M, Miličić B, Kmezić S, Oluić B, Aleksić M, Pavlović-Marković A, Popović D. Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients. in Gastroenterology Research & Practice. 2020;2020.
doi:10.1155/2020/2065383 .

Dragašević, Sanja, Sokić-Milutinović, Aleksandra, Stojković-Lalošević, Milica, Milovanović, Tamara, Đuranović, Srđan, Jovanović, Ivan, Rajić, Sanja, Stojković, Mirjana, Miličić, Biljana, Kmezić, Stefan, Oluić, Branislav, Aleksić, Marko, Pavlović-Marković, Aleksandra, Popović, Dragan, "Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn's Disease Patients" in Gastroenterology Research & Practice, 2020 (2020),
https://doi.org/10.1155/2020/2065383 . .

TY  - JOUR
AU  - Velicković, Jelena
AU  - Palibrk, Ivan
AU  - Miličić, Biljana
AU  - Velicković, Dejan
AU  - Jovanović, Bojan
AU  - Rakić, Goran
AU  - Petrović, Milorad
AU  - Bumbaširević, Vesna
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2461
AB  - Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L-0], at 4 hours (L-4), 12 hours (L-12), and 24 hours (L-24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge or death. Receiver operating characteristic (ROC) curves were used to determine the predictive value of lactate levels for postoperative outcomes. The best cut-off lactate values were calculated to differentiate between patients with and without complications, and outcomes in patients with lactate levels above and below the cut-off thresholds were compared. Univariate and multivariate analyses were used to identify variables associated with POCs and mortality. Seventy-six patients developed 184 complications (18 deaths), while 119 had no complications. Serum lactate levels were higher in patients with complications at all time points compared to those without complications (p  lt  0.001). L-12 had the highest predictive value for complications (AUROC(12) = 0.787; 95% CI: 0.719-0.854; p  lt  0.001) and mortality (AUROC(12) = 0.872; 95% CI: 0.794-0.950;p  lt  0.00l). The best L-12 cut-off value for complications and mortality was 1.35 mmol/l and 1.85 mmol/l, respectively. Multivariate analysis revealed that L-1(2) >= 1.35 mml/l was an independent predictor of postoperative morbidity (OR 2.58; 95% CI 1.27-5.24,p = 0.001) . L-24 was predictive of POCs after major abdominal surgery. L-12 had the best power to discriminate between patients with and without POCs and was associated with a longer hospital stay.
PB  - Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa
T2  - Bosnian Journal of Basic Medical Sciences
T1  - The association of early postoperative lactate levels with morbidity after elective major abdominal surgery
VL  - 19
IS  - 1
SP  - 72
EP  - 80
DO  - 10.17305/bjbms.2018.3186
ER  - 

@article{
author = "Velicković, Jelena and Palibrk, Ivan and Miličić, Biljana and Velicković, Dejan and Jovanović, Bojan and Rakić, Goran and Petrović, Milorad and Bumbaširević, Vesna",
year = "2019",
abstract = "Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POCs), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L-0], at 4 hours (L-4), 12 hours (L-12), and 24 hours (L-24) after the operation. Demographic and perioperative clinical data were collected. Patients were monitored for complications until discharge or death. Receiver operating characteristic (ROC) curves were used to determine the predictive value of lactate levels for postoperative outcomes. The best cut-off lactate values were calculated to differentiate between patients with and without complications, and outcomes in patients with lactate levels above and below the cut-off thresholds were compared. Univariate and multivariate analyses were used to identify variables associated with POCs and mortality. Seventy-six patients developed 184 complications (18 deaths), while 119 had no complications. Serum lactate levels were higher in patients with complications at all time points compared to those without complications (p  lt  0.001). L-12 had the highest predictive value for complications (AUROC(12) = 0.787; 95% CI: 0.719-0.854; p  lt  0.001) and mortality (AUROC(12) = 0.872; 95% CI: 0.794-0.950;p  lt  0.00l). The best L-12 cut-off value for complications and mortality was 1.35 mmol/l and 1.85 mmol/l, respectively. Multivariate analysis revealed that L-1(2) >= 1.35 mml/l was an independent predictor of postoperative morbidity (OR 2.58; 95% CI 1.27-5.24,p = 0.001) . L-24 was predictive of POCs after major abdominal surgery. L-12 had the best power to discriminate between patients with and without POCs and was associated with a longer hospital stay.",
publisher = "Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa",
journal = "Bosnian Journal of Basic Medical Sciences",
title = "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery",
volume = "19",
number = "1",
pages = "72-80",
doi = "10.17305/bjbms.2018.3186"
}

Velicković, J., Palibrk, I., Miličić, B., Velicković, D., Jovanović, B., Rakić, G., Petrović, M.,& Bumbaširević, V.. (2019). The association of early postoperative lactate levels with morbidity after elective major abdominal surgery. in Bosnian Journal of Basic Medical Sciences
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, Cekalusa., 19(1), 72-80.
https://doi.org/10.17305/bjbms.2018.3186

Velicković J, Palibrk I, Miličić B, Velicković D, Jovanović B, Rakić G, Petrović M, Bumbaširević V. The association of early postoperative lactate levels with morbidity after elective major abdominal surgery. in Bosnian Journal of Basic Medical Sciences. 2019;19(1):72-80.
doi:10.17305/bjbms.2018.3186 .

Velicković, Jelena, Palibrk, Ivan, Miličić, Biljana, Velicković, Dejan, Jovanović, Bojan, Rakić, Goran, Petrović, Milorad, Bumbaširević, Vesna, "The association of early postoperative lactate levels with morbidity after elective major abdominal surgery" in Bosnian Journal of Basic Medical Sciences, 19, no. 1 (2019):72-80,
https://doi.org/10.17305/bjbms.2018.3186 . .

TY  - JOUR
AU  - Simić, Dušica
AU  - Simić, Irena
AU  - Stević, Marija
AU  - Jovičić, Nevena
AU  - Mitrović, Maja
AU  - Budić, Ivana
AU  - Milenović, Miodrag
AU  - Marjanović, Vesna
AU  - Miličić, Biljana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2436
AB  - Introduction/Objective Pain is a disturbing experience associated with existing or potential tissue damage, with a sensory, emotional, cognitive, and social component. The aim of this study was to show the efficiency of regional anesthetic techniques in postoperative pain in children. Methods The retrospective cohort study was conducted on a group of 564 pediatric patients during the period from 2013 to 2016. Types of regional anesthesia were classified into the following six groups: caudal, epidural, spinal block, upper limb blocks, lower limb blocks, and truncal nerve block. From statistical methods, we used descriptive statistical methods of absolute and relative numbers, measurements of variability, central tendencies for numerical features, and methods of inferential statistics. We used the ch2 test for the attributive features of observations. Results In relation to the postoperative time when an analgesic was required, a statistically significant difference was observed in the age of children (p = 0.000), disease diagnosis (p = 0.000), type of block (p = 0.000), type of local anesthetic (p = 0.000), and type of anesthesia or sedation preoperatively (p = 0.005). Conclusion Postoperative analgesia was most needed by older children and children who were awake during surgery. Children with injuries and tumors need postoperative analgesia the earliest. The longest postoperative analgesia was recorded in patients who received caudal block. The longest postoperative analgesia can be seen in patients who received levobupivacaine, bupivacaine or levobupivacaine combined with lidocaine to perform the block.
AB  - Uvod/Cilj Bol predstavlja uznemirujuće iskustvo koje je povezano sa postojećim ili mogućim oštećenjem tkiva, sa senzornom, emocionalnom, kognitivnom i socijalnom komponentom. Cilj ove studije je prikaz efikasnosti tehnika regionalne anestezije na postoperativni bol kod dece. Metode Retrospektivna kohortna studija je sprovedena na grupi od 564 pedijatrijskih bolesnika u periodu od 2013. do 2016. godine. Vrste regionalne anestezije su klasifikovane u šest grupa: kaudalna, epiduralna, spinalna, blokovi gornjih ekstremiteta, donjih ekstremiteta i blok trupa. Od statističkih metoda koristili smo deskriptivne statističke metode apsolutnih i relativnih brojeva za atributivna obeležja posmatranja, mere varijabiliteta, centralne tendencije za numerička obeležja i metode inferencijalne statistike. Izbor testova za numerička obeležja posmatranja zavisiće od raspodele podataka. Za atributivna obeležja posmatranja koristili smo ch2 test. Rezultati U odnosu na postoperativno vreme kada je bio potreban analgetik, statistički značajna razlika uočena je u uzrastu dece (p = 0,000), dijagnozi bolesti (p = 0,000), vrsti bloka (p = 0,000), vrsti korišćenog lokalnog anestetika (p = 0,000), kao i vrsti perioperativne anestezije ili sedacije (p = 0,005). Zaključak Postoperativna analgezija je najpotrebnija starijoj deci i deci koja su bila budna tokom hirurške intervencije. Najranija postoperativna analgezija je potrebna deci sa povredama i tumorima. Najduža postoperativna analgezija je zabeležena kod bolesnika koji su dobili kaudalni blok, kao i bolesnika koji su primili levobupivakain, bupivakain ili levobupivakain u kombinaciji sa bupivakainom za izvođenje bloka.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The role of regional anesthesia in the postoperative analgesia in pediatric patients
T1  - Uloga regionalne anestezije u postoperativnoj analgeziji pedijatrijskih bolesnika
VL  - 147
IS  - 5-6
SP  - 316
EP  - 320
DO  - 10.2298/SARH180116067S
ER  - 

@article{
author = "Simić, Dušica and Simić, Irena and Stević, Marija and Jovičić, Nevena and Mitrović, Maja and Budić, Ivana and Milenović, Miodrag and Marjanović, Vesna and Miličić, Biljana",
year = "2019",
abstract = "Introduction/Objective Pain is a disturbing experience associated with existing or potential tissue damage, with a sensory, emotional, cognitive, and social component. The aim of this study was to show the efficiency of regional anesthetic techniques in postoperative pain in children. Methods The retrospective cohort study was conducted on a group of 564 pediatric patients during the period from 2013 to 2016. Types of regional anesthesia were classified into the following six groups: caudal, epidural, spinal block, upper limb blocks, lower limb blocks, and truncal nerve block. From statistical methods, we used descriptive statistical methods of absolute and relative numbers, measurements of variability, central tendencies for numerical features, and methods of inferential statistics. We used the ch2 test for the attributive features of observations. Results In relation to the postoperative time when an analgesic was required, a statistically significant difference was observed in the age of children (p = 0.000), disease diagnosis (p = 0.000), type of block (p = 0.000), type of local anesthetic (p = 0.000), and type of anesthesia or sedation preoperatively (p = 0.005). Conclusion Postoperative analgesia was most needed by older children and children who were awake during surgery. Children with injuries and tumors need postoperative analgesia the earliest. The longest postoperative analgesia was recorded in patients who received caudal block. The longest postoperative analgesia can be seen in patients who received levobupivacaine, bupivacaine or levobupivacaine combined with lidocaine to perform the block., Uvod/Cilj Bol predstavlja uznemirujuće iskustvo koje je povezano sa postojećim ili mogućim oštećenjem tkiva, sa senzornom, emocionalnom, kognitivnom i socijalnom komponentom. Cilj ove studije je prikaz efikasnosti tehnika regionalne anestezije na postoperativni bol kod dece. Metode Retrospektivna kohortna studija je sprovedena na grupi od 564 pedijatrijskih bolesnika u periodu od 2013. do 2016. godine. Vrste regionalne anestezije su klasifikovane u šest grupa: kaudalna, epiduralna, spinalna, blokovi gornjih ekstremiteta, donjih ekstremiteta i blok trupa. Od statističkih metoda koristili smo deskriptivne statističke metode apsolutnih i relativnih brojeva za atributivna obeležja posmatranja, mere varijabiliteta, centralne tendencije za numerička obeležja i metode inferencijalne statistike. Izbor testova za numerička obeležja posmatranja zavisiće od raspodele podataka. Za atributivna obeležja posmatranja koristili smo ch2 test. Rezultati U odnosu na postoperativno vreme kada je bio potreban analgetik, statistički značajna razlika uočena je u uzrastu dece (p = 0,000), dijagnozi bolesti (p = 0,000), vrsti bloka (p = 0,000), vrsti korišćenog lokalnog anestetika (p = 0,000), kao i vrsti perioperativne anestezije ili sedacije (p = 0,005). Zaključak Postoperativna analgezija je najpotrebnija starijoj deci i deci koja su bila budna tokom hirurške intervencije. Najranija postoperativna analgezija je potrebna deci sa povredama i tumorima. Najduža postoperativna analgezija je zabeležena kod bolesnika koji su dobili kaudalni blok, kao i bolesnika koji su primili levobupivakain, bupivakain ili levobupivakain u kombinaciji sa bupivakainom za izvođenje bloka.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The role of regional anesthesia in the postoperative analgesia in pediatric patients, Uloga regionalne anestezije u postoperativnoj analgeziji pedijatrijskih bolesnika",
volume = "147",
number = "5-6",
pages = "316-320",
doi = "10.2298/SARH180116067S"
}

Simić, D., Simić, I., Stević, M., Jovičić, N., Mitrović, M., Budić, I., Milenović, M., Marjanović, V.,& Miličić, B.. (2019). The role of regional anesthesia in the postoperative analgesia in pediatric patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 147(5-6), 316-320.
https://doi.org/10.2298/SARH180116067S

Simić D, Simić I, Stević M, Jovičić N, Mitrović M, Budić I, Milenović M, Marjanović V, Miličić B. The role of regional anesthesia in the postoperative analgesia in pediatric patients. in Srpski arhiv za celokupno lekarstvo. 2019;147(5-6):316-320.
doi:10.2298/SARH180116067S .

Simić, Dušica, Simić, Irena, Stević, Marija, Jovičić, Nevena, Mitrović, Maja, Budić, Ivana, Milenović, Miodrag, Marjanović, Vesna, Miličić, Biljana, "The role of regional anesthesia in the postoperative analgesia in pediatric patients" in Srpski arhiv za celokupno lekarstvo, 147, no. 5-6 (2019):316-320,
https://doi.org/10.2298/SARH180116067S . .

TY  - JOUR
AU  - Oleg, Dobrinin
AU  - Alexander, Lazarov
AU  - Konstantinović, Vitomir S.
AU  - Sipić, Olga
AU  - Damir, Siljanovski
AU  - Miličić, Biljana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2419
AB  - BACKGROUND Immediate functional loading is a hot topic in dental implantology. The use of conventional dental implants has proven to be successful for very few techniques and if enough jaw bone is present. In this study we report about the outcomes of treatments using the technology of the Strategic Implant (R) in specialized clinics without any patient selection. The purpose of this study was to evaluate the presently used protocol for immediate functional loading (within max. 3 days) of single piece implants which are placed according to the following principles- Axial implants with 2nd cortical anchorage (BECES (R)/BECES (R) N/BCS (R)), Lateral implants with dual mode of integration and cortical anchorage in horizontal direction (BOI (R)), Single piece compression screw implants (KOS/KOC) with conical endosseous implant body. MATERIALS AND METHODS This retrospective cohort study included totally 394 patients who were treated with 4570 immediately loaded single piece implants (BECES (R) or BECES N (R), BCS (R), BOI (R) BBBS/BAST and KOC (R) Strategic Implant (R), all obtained from Simpladent GmbH, Switzerland, Manufacturer: Dr. Ihde Dental AG) supporting fixed complete-arch maxillary or mandibular metal-acrylic prostheses, or metal-ceramic bridges or segment reconstructions in both jaws. Furthermore, 26 implants for single tooth replacement were inserted during the study period and 90 (2.0%) single tooth on more than one implant reconstruction have been used, as shown in Table 1. The patients were asked to return for follow up examinations at 6, 12, 18 and 24 months postoperatively. Radiographic assessment of: The marginal bone level, The integration of the load transmitting parts of the implants, The healing of sockets containing vertical implant parts, were performed after at least 1 year in function for all patients. Furthermore The reliability of possible target corticals The survival of bent and unbent implants, and the The survival of implants in fresh extraction sockets and healed bone were determined. RESULTS Immediate functional loading of using multiple, cortically anchored Strategic Implant (R) as a support for fixed full-arch and segment prosthesis in the upper and lower jaw demonstrated a high cumulative implant survival rate (95.7%) after an average observation period of 18.93+8.41 months. The success rate of the individual implant depends on the target cortical in which it is anchored. Bent implants showed a better survival rate compared to non-bent implants, 98.5% vs 94.5%, (p=0.003). Basal screw implant showed a similar survival rate as compressive screw implants. Combination implants (KOS plus) showed a significantly lower survival rate. BOI implant showed the highest possible survival rate, however the number of implants was low compared to other types observed in this study. Clinical Significance- Immediate functional loading of single piece dental implants has become an accepted treatment modality for fixed restorations in totally edentulous mandibles and in edentulous maxillae. Nevertheless, studies regarding immediate loading procedures in extraction sites in both jaws, as well as in segment reconstructions and single teeth replacements, are limited. From the results of this study it can be concluded, that The concept of treating edentulous "osseo-fixation" anchoring basal implants in the 2nd cortical (instead of trying to achieve "osseo-integration" in the 1st cortical and the underlying spongy bone) leads to a high success rate and allows functional immediate loading. The results of the study are limited (although the sample size is enormous compared to other published studies in dental implantology) when it comes to determining if age, gender, smoking and generalized diseases or combinations thereof, and this is due to the very low complication rate of the treatment observed. CONCLUSION Within the limits of this study, it can be concluded that treatments with the technology of the Strategic Implant (R) give good results both in the edentulous and partly dentulous maxilla and mandible as well as for single tooth replacement. Furthermore, these implants may be placed into fresh extraction sockets almost with the same success as in healed bone. Bending of the implant necks rather increases the chances of survival for these implants. The survival of the individual implant depends on the chosen target cortical (2nd/3rd cortical) more than on anything else.
PB  - Journal Evolution Medical & Dental Sciences, Karnataka
T2  - Journal of Evolution of Medical & Dental Sciences / JEMDS
T1  - Immediate-functional loading concept with one-piece implants (beces/becesn/kos/boi) in the mandible and maxilla- a multi-center retrospective clinical study
VL  - 8
IS  - 5
SP  - 306
EP  - 315
DO  - 10.14260/jemds/2019/67
ER  - 

@article{
author = "Oleg, Dobrinin and Alexander, Lazarov and Konstantinović, Vitomir S. and Sipić, Olga and Damir, Siljanovski and Miličić, Biljana",
year = "2019",
abstract = "BACKGROUND Immediate functional loading is a hot topic in dental implantology. The use of conventional dental implants has proven to be successful for very few techniques and if enough jaw bone is present. In this study we report about the outcomes of treatments using the technology of the Strategic Implant (R) in specialized clinics without any patient selection. The purpose of this study was to evaluate the presently used protocol for immediate functional loading (within max. 3 days) of single piece implants which are placed according to the following principles- Axial implants with 2nd cortical anchorage (BECES (R)/BECES (R) N/BCS (R)), Lateral implants with dual mode of integration and cortical anchorage in horizontal direction (BOI (R)), Single piece compression screw implants (KOS/KOC) with conical endosseous implant body. MATERIALS AND METHODS This retrospective cohort study included totally 394 patients who were treated with 4570 immediately loaded single piece implants (BECES (R) or BECES N (R), BCS (R), BOI (R) BBBS/BAST and KOC (R) Strategic Implant (R), all obtained from Simpladent GmbH, Switzerland, Manufacturer: Dr. Ihde Dental AG) supporting fixed complete-arch maxillary or mandibular metal-acrylic prostheses, or metal-ceramic bridges or segment reconstructions in both jaws. Furthermore, 26 implants for single tooth replacement were inserted during the study period and 90 (2.0%) single tooth on more than one implant reconstruction have been used, as shown in Table 1. The patients were asked to return for follow up examinations at 6, 12, 18 and 24 months postoperatively. Radiographic assessment of: The marginal bone level, The integration of the load transmitting parts of the implants, The healing of sockets containing vertical implant parts, were performed after at least 1 year in function for all patients. Furthermore The reliability of possible target corticals The survival of bent and unbent implants, and the The survival of implants in fresh extraction sockets and healed bone were determined. RESULTS Immediate functional loading of using multiple, cortically anchored Strategic Implant (R) as a support for fixed full-arch and segment prosthesis in the upper and lower jaw demonstrated a high cumulative implant survival rate (95.7%) after an average observation period of 18.93+8.41 months. The success rate of the individual implant depends on the target cortical in which it is anchored. Bent implants showed a better survival rate compared to non-bent implants, 98.5% vs 94.5%, (p=0.003). Basal screw implant showed a similar survival rate as compressive screw implants. Combination implants (KOS plus) showed a significantly lower survival rate. BOI implant showed the highest possible survival rate, however the number of implants was low compared to other types observed in this study. Clinical Significance- Immediate functional loading of single piece dental implants has become an accepted treatment modality for fixed restorations in totally edentulous mandibles and in edentulous maxillae. Nevertheless, studies regarding immediate loading procedures in extraction sites in both jaws, as well as in segment reconstructions and single teeth replacements, are limited. From the results of this study it can be concluded, that The concept of treating edentulous "osseo-fixation" anchoring basal implants in the 2nd cortical (instead of trying to achieve "osseo-integration" in the 1st cortical and the underlying spongy bone) leads to a high success rate and allows functional immediate loading. The results of the study are limited (although the sample size is enormous compared to other published studies in dental implantology) when it comes to determining if age, gender, smoking and generalized diseases or combinations thereof, and this is due to the very low complication rate of the treatment observed. CONCLUSION Within the limits of this study, it can be concluded that treatments with the technology of the Strategic Implant (R) give good results both in the edentulous and partly dentulous maxilla and mandible as well as for single tooth replacement. Furthermore, these implants may be placed into fresh extraction sockets almost with the same success as in healed bone. Bending of the implant necks rather increases the chances of survival for these implants. The survival of the individual implant depends on the chosen target cortical (2nd/3rd cortical) more than on anything else.",
publisher = "Journal Evolution Medical & Dental Sciences, Karnataka",
journal = "Journal of Evolution of Medical & Dental Sciences / JEMDS",
title = "Immediate-functional loading concept with one-piece implants (beces/becesn/kos/boi) in the mandible and maxilla- a multi-center retrospective clinical study",
volume = "8",
number = "5",
pages = "306-315",
doi = "10.14260/jemds/2019/67"
}

Oleg, D., Alexander, L., Konstantinović, V. S., Sipić, O., Damir, S.,& Miličić, B.. (2019). Immediate-functional loading concept with one-piece implants (beces/becesn/kos/boi) in the mandible and maxilla- a multi-center retrospective clinical study. in Journal of Evolution of Medical & Dental Sciences / JEMDS
Journal Evolution Medical & Dental Sciences, Karnataka., 8(5), 306-315.
https://doi.org/10.14260/jemds/2019/67

Oleg D, Alexander L, Konstantinović VS, Sipić O, Damir S, Miličić B. Immediate-functional loading concept with one-piece implants (beces/becesn/kos/boi) in the mandible and maxilla- a multi-center retrospective clinical study. in Journal of Evolution of Medical & Dental Sciences / JEMDS. 2019;8(5):306-315.
doi:10.14260/jemds/2019/67 .

Oleg, Dobrinin, Alexander, Lazarov, Konstantinović, Vitomir S., Sipić, Olga, Damir, Siljanovski, Miličić, Biljana, "Immediate-functional loading concept with one-piece implants (beces/becesn/kos/boi) in the mandible and maxilla- a multi-center retrospective clinical study" in Journal of Evolution of Medical & Dental Sciences / JEMDS, 8, no. 5 (2019):306-315,
https://doi.org/10.14260/jemds/2019/67 . .

TY  - JOUR
AU  - Milovanović, Tamara
AU  - Dragašević, Sanja
AU  - Stojković-Lalošević, Milica
AU  - Zgradić, Sanja
AU  - Miličić, Biljana
AU  - Dumić, Igor
AU  - Kmezić, Stefan
AU  - Saponjski, Dušan
AU  - Antić, Andrija
AU  - Marković, Velimir
AU  - Popović, Dragan
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2416
AB  - Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non-alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD.
PB  - Mdpi, Basel
T2  - Medicina-Lithuania
T1  - Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study
VL  - 55
IS  - 10
DO  - 10.3390/medicina55100697
ER  - 

@article{
author = "Milovanović, Tamara and Dragašević, Sanja and Stojković-Lalošević, Milica and Zgradić, Sanja and Miličić, Biljana and Dumić, Igor and Kmezić, Stefan and Saponjski, Dušan and Antić, Andrija and Marković, Velimir and Popović, Dragan",
year = "2019",
abstract = "Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non-alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD.",
publisher = "Mdpi, Basel",
journal = "Medicina-Lithuania",
title = "Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study",
volume = "55",
number = "10",
doi = "10.3390/medicina55100697"
}

Milovanović, T., Dragašević, S., Stojković-Lalošević, M., Zgradić, S., Miličić, B., Dumić, I., Kmezić, S., Saponjski, D., Antić, A., Marković, V.,& Popović, D.. (2019). Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study. in Medicina-Lithuania
Mdpi, Basel., 55(10).
https://doi.org/10.3390/medicina55100697

Milovanović T, Dragašević S, Stojković-Lalošević M, Zgradić S, Miličić B, Dumić I, Kmezić S, Saponjski D, Antić A, Marković V, Popović D. Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study. in Medicina-Lithuania. 2019;55(10).
doi:10.3390/medicina55100697 .

Milovanović, Tamara, Dragašević, Sanja, Stojković-Lalošević, Milica, Zgradić, Sanja, Miličić, Biljana, Dumić, Igor, Kmezić, Stefan, Saponjski, Dušan, Antić, Andrija, Marković, Velimir, Popović, Dragan, "Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease-A Cross Sectional Study" in Medicina-Lithuania, 55, no. 10 (2019),
https://doi.org/10.3390/medicina55100697 . .

TY  - JOUR
AU  - Radović, Mina
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Ležaić, Višnja
AU  - Miličić, Biljana
AU  - Velinović, Miloš
AU  - Karan, Radmila
AU  - Simić-Ogrizović, Sanja
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2404
AB  - Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil GelatinaseAssociated Lipocalin (N G AL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary N G AL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as lowrisk for developing CSA-AKI. u NGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uN G A L and KIM-1 levels compared to patients without CSA-AKI. Unlike uN G A L and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration > 4 mmol/L carried dramatically higher risk for developing CSA-AKI (O R 6.3 [1.9-20.5]). Conclusions: Unlike uN G A L and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB.
AB  - Uvod: Akutno ostećenje bubrega nakon kardiohirurskih procedura (KH-AOB) nastaje često i kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Neutrofilna želatinaza udružena sa lipokalinom (NGAL), bubrežni štetni molekul-1 (KIM-1) i laktat su novi biomarkeri KH-AOB ali do sada nisu ispitivani kod niskorizičnih bolesnika. Cilj: Ispitati urinarni NGAL (uNGAL), KIM-1 i laktat kao biomarkere KH-AOB kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Metode: Ovom prospektivnom opservacionom studijom obuhvaćeno je 100 odraslih elektivnih kardiohirurških bolesnika koji su ocenjeni kao niskorizični za razvoj KH-AOB. UNGAL, KIM-1 i laktat su određivani preoperativno, na kraju kardiopulmonalnog bajpasa (KPB) kao i 3, 12, 24 i 48 sati kasnije. Rezultati: KH-AOB se razvilo kod 15 bolesnika. Bolesnici sa KH-AOB su imali značajno više vrednosti lakatata ali slične vrednosti uNGAL i KIM-1 u poređenju sa bolesnicima bez KH-AOB. Za razliku od uN GAL i KIM-1, vrednost lakatata posle operacije se pokazala kao pouzdan biomarker KH-AOB sa najvišim OR 2.7 [1,4-4,9] 24 sata nakon zavrsetka KPB. Vrednosti lakatata > 4 mmol/L su bile povezane sa dramatično povišenim rizikom za nastanak KH-AOB (O R 6,3 [1,9-20,5]). Zaključak: Za razliku od uN GAL i KIM-1, vrednosti lakata posle operacije su bile značajan nezavisni prediktor razvoja KH-AOB sa najboljom prediktivnom vrednošću 24 sata nakon završetka KPB.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients
T1  - Serumski laktat kao pouzdan biomarker akutnog oštećenja bubrega kod niskorizičnih kardiohirurških bolesnika
VL  - 38
IS  - 2
SP  - 118
EP  - 125
DO  - 10.2478/jomb-2018-0018
ER  - 

@article{
author = "Radović, Mina and Bojić, Suzana and Kotur-Stevuljević, Jelena and Ležaić, Višnja and Miličić, Biljana and Velinović, Miloš and Karan, Radmila and Simić-Ogrizović, Sanja",
year = "2019",
abstract = "Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil GelatinaseAssociated Lipocalin (N G AL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary N G AL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as lowrisk for developing CSA-AKI. u NGAL, KIM-1 and lactate were measured preoperatively, at the end of cardiopulmonary bypass (CPB) and 3, 12, 24 and 48 h later. Results: Fifteen patients developed CSA-AKI. Patients with CSA-AKI had significantly higher lactate but similar uN G A L and KIM-1 levels compared to patients without CSA-AKI. Unlike uN G A L and KIM-1, postoperative lactate was good biomarker of CSA-AKI with the highest odds ratio (OR) 2.7 [1.4-4.9] 24 h after CPB. Peak lactate concentration > 4 mmol/L carried dramatically higher risk for developing CSA-AKI (O R 6.3 [1.9-20.5]). Conclusions: Unlike uN G A L and KIM-1, postoperative lactate was significant independent predictor of CSA-AKI with the highest odds ratio 24 h after CPB., Uvod: Akutno ostećenje bubrega nakon kardiohirurskih procedura (KH-AOB) nastaje često i kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Neutrofilna želatinaza udružena sa lipokalinom (NGAL), bubrežni štetni molekul-1 (KIM-1) i laktat su novi biomarkeri KH-AOB ali do sada nisu ispitivani kod niskorizičnih bolesnika. Cilj: Ispitati urinarni NGAL (uNGAL), KIM-1 i laktat kao biomarkere KH-AOB kod bolesnika koji su ocenjeni kao niskorizični za nastanak KH-AOB. Metode: Ovom prospektivnom opservacionom studijom obuhvaćeno je 100 odraslih elektivnih kardiohirurških bolesnika koji su ocenjeni kao niskorizični za razvoj KH-AOB. UNGAL, KIM-1 i laktat su određivani preoperativno, na kraju kardiopulmonalnog bajpasa (KPB) kao i 3, 12, 24 i 48 sati kasnije. Rezultati: KH-AOB se razvilo kod 15 bolesnika. Bolesnici sa KH-AOB su imali značajno više vrednosti lakatata ali slične vrednosti uNGAL i KIM-1 u poređenju sa bolesnicima bez KH-AOB. Za razliku od uN GAL i KIM-1, vrednost lakatata posle operacije se pokazala kao pouzdan biomarker KH-AOB sa najvišim OR 2.7 [1,4-4,9] 24 sata nakon zavrsetka KPB. Vrednosti lakatata > 4 mmol/L su bile povezane sa dramatično povišenim rizikom za nastanak KH-AOB (O R 6,3 [1,9-20,5]). Zaključak: Za razliku od uN GAL i KIM-1, vrednosti lakata posle operacije su bile značajan nezavisni prediktor razvoja KH-AOB sa najboljom prediktivnom vrednošću 24 sata nakon završetka KPB.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients, Serumski laktat kao pouzdan biomarker akutnog oštećenja bubrega kod niskorizičnih kardiohirurških bolesnika",
volume = "38",
number = "2",
pages = "118-125",
doi = "10.2478/jomb-2018-0018"
}

Radović, M., Bojić, S., Kotur-Stevuljević, J., Ležaić, V., Miličić, B., Velinović, M., Karan, R.,& Simić-Ogrizović, S.. (2019). Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(2), 118-125.
https://doi.org/10.2478/jomb-2018-0018

Radović M, Bojić S, Kotur-Stevuljević J, Ležaić V, Miličić B, Velinović M, Karan R, Simić-Ogrizović S. Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients. in Journal of Medical Biochemistry. 2019;38(2):118-125.
doi:10.2478/jomb-2018-0018 .

Radović, Mina, Bojić, Suzana, Kotur-Stevuljević, Jelena, Ležaić, Višnja, Miličić, Biljana, Velinović, Miloš, Karan, Radmila, Simić-Ogrizović, Sanja, "Serum lactate as reliable biomarker of acute kidney injury in low-risk cardiac surgery patients" in Journal of Medical Biochemistry, 38, no. 2 (2019):118-125,
https://doi.org/10.2478/jomb-2018-0018 . .

TY  - JOUR
AU  - Mandić, Jelena
AU  - Jovanović, Svetlana
AU  - Mandinić, Zoran
AU  - Ivanović, Mirjana
AU  - Kosanović, Dušan
AU  - Miličić, Biljana
AU  - Živojinović-Toumba, Vesna
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2331
AB  - Background/Aim. Due to their primary medical condition, children with special needs often display lower levels of oral hygiene, larger prevalence of caries and other oral diseases. The aim of this study was to estimate the prevalence of dental caries, oral cleanliness and presence of malocclusion in children with disabilities, as well as to evaluate eruption time of the permanent molars. Methods. Case-control study was carried out on a group of 107 children with disabilities at the Faculty of Dental Medicine, University of Belgrade, Serbia. The control group comprised of 104 healthy school children. Results. Children with disabilities had statistically higher mean [decayed missing and filled teeth - dmft for primary DMF for permanent dentition (dmft DMFT)] values in both dentitions than children from the control group (p  lt  0.05). Oral cleanliness level was much lower in children with disabilities. A significantly higher percentage of Class II malocclusions and a higher tendency to have a delayed time of eruption of permanent molars were observed in the test group in permanent dentition. Conclusion. Considering poor oral health status and higher tendency for development of malloclusions and delayed eruption, it is necessary to develop preventive dental programmes for children with special needs, as well as improve public awareness about these issues.
AB  - Uvod/Cilj. Deca sa posebnim potrebama često zbog svoje primarne bolesti, imaju niži nivo oralne higijene i veću prevalencu karijesa i drugih oralnih oboljenja. Cilj rada bio je da se proceni prevalenca karijesa, nivoa oralne higijene i prisustvo malokluzija kod dece sa posebnim potrebama, kao i vreme erupcije stalnih molara. Metode. Ispitivanjem oralnog zdravlja obuhvaćeno je 107 dece sa posebnim potrebama na Klinici za dečju i preventivnu stomatologiju Stomatološkog fakulteta u Beogradu. Kontrolnu grupu je činilo 104 zdrave školske dece. Rezultati. Deca sa posebnim potrebama imala su statistički značajno viši nivo indeksa karijesnih, ekstrahovanih i plombiranih zuba (KEP) u obe denticije, u odnosu na kontrolnu grupu (p  lt  0.05). Nivo oralne higijene bio je lošiji kod dece sa posebnim potrebama. Takođe, primećeno je statistički značajno povećanje malokluzija klase II, kao i kasnije vreme erupcije stalnih molara kod dece sa posebnim potrebama u odnosu na kontrolnu grupu. Zaključak. Zbog lošijeg stanja oralnog zdravlja i povećane verovatnoće razvoja malokluzija i odloženog nicanja zuba, neophodno je formirati preventivne stomatološke programe za decu sa posebnim potrebama, kao i poboljšati informisanost javnosti o ovom problemu.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Oral health in children with special needs
T1  - Stanje oralnog zdravlja dece sa posebnim potrebama
VL  - 75
IS  - 7
SP  - 675
EP  - 681
DO  - 10.2298/VSP160707372M
ER  - 

@article{
author = "Mandić, Jelena and Jovanović, Svetlana and Mandinić, Zoran and Ivanović, Mirjana and Kosanović, Dušan and Miličić, Biljana and Živojinović-Toumba, Vesna",
year = "2018",
abstract = "Background/Aim. Due to their primary medical condition, children with special needs often display lower levels of oral hygiene, larger prevalence of caries and other oral diseases. The aim of this study was to estimate the prevalence of dental caries, oral cleanliness and presence of malocclusion in children with disabilities, as well as to evaluate eruption time of the permanent molars. Methods. Case-control study was carried out on a group of 107 children with disabilities at the Faculty of Dental Medicine, University of Belgrade, Serbia. The control group comprised of 104 healthy school children. Results. Children with disabilities had statistically higher mean [decayed missing and filled teeth - dmft for primary DMF for permanent dentition (dmft DMFT)] values in both dentitions than children from the control group (p  lt  0.05). Oral cleanliness level was much lower in children with disabilities. A significantly higher percentage of Class II malocclusions and a higher tendency to have a delayed time of eruption of permanent molars were observed in the test group in permanent dentition. Conclusion. Considering poor oral health status and higher tendency for development of malloclusions and delayed eruption, it is necessary to develop preventive dental programmes for children with special needs, as well as improve public awareness about these issues., Uvod/Cilj. Deca sa posebnim potrebama često zbog svoje primarne bolesti, imaju niži nivo oralne higijene i veću prevalencu karijesa i drugih oralnih oboljenja. Cilj rada bio je da se proceni prevalenca karijesa, nivoa oralne higijene i prisustvo malokluzija kod dece sa posebnim potrebama, kao i vreme erupcije stalnih molara. Metode. Ispitivanjem oralnog zdravlja obuhvaćeno je 107 dece sa posebnim potrebama na Klinici za dečju i preventivnu stomatologiju Stomatološkog fakulteta u Beogradu. Kontrolnu grupu je činilo 104 zdrave školske dece. Rezultati. Deca sa posebnim potrebama imala su statistički značajno viši nivo indeksa karijesnih, ekstrahovanih i plombiranih zuba (KEP) u obe denticije, u odnosu na kontrolnu grupu (p  lt  0.05). Nivo oralne higijene bio je lošiji kod dece sa posebnim potrebama. Takođe, primećeno je statistički značajno povećanje malokluzija klase II, kao i kasnije vreme erupcije stalnih molara kod dece sa posebnim potrebama u odnosu na kontrolnu grupu. Zaključak. Zbog lošijeg stanja oralnog zdravlja i povećane verovatnoće razvoja malokluzija i odloženog nicanja zuba, neophodno je formirati preventivne stomatološke programe za decu sa posebnim potrebama, kao i poboljšati informisanost javnosti o ovom problemu.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Oral health in children with special needs, Stanje oralnog zdravlja dece sa posebnim potrebama",
volume = "75",
number = "7",
pages = "675-681",
doi = "10.2298/VSP160707372M"
}

Mandić, J., Jovanović, S., Mandinić, Z., Ivanović, M., Kosanović, D., Miličić, B.,& Živojinović-Toumba, V.. (2018). Oral health in children with special needs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(7), 675-681.
https://doi.org/10.2298/VSP160707372M

Mandić J, Jovanović S, Mandinić Z, Ivanović M, Kosanović D, Miličić B, Živojinović-Toumba V. Oral health in children with special needs. in Vojnosanitetski pregled. 2018;75(7):675-681.
doi:10.2298/VSP160707372M .

Mandić, Jelena, Jovanović, Svetlana, Mandinić, Zoran, Ivanović, Mirjana, Kosanović, Dušan, Miličić, Biljana, Živojinović-Toumba, Vesna, "Oral health in children with special needs" in Vojnosanitetski pregled, 75, no. 7 (2018):675-681,
https://doi.org/10.2298/VSP160707372M . .

TY  - JOUR
AU  - Perić, Mirjana
AU  - Živković, Rade
AU  - Milić-Lemić, Aleksandra
AU  - Radunović, Milena
AU  - Miličić, Biljana
AU  - Arsić-Arsenijević, Valentina
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2298
AB  - Objectives. 1) To select patients with Candida-related denture stomatitis (DS) and to study possible risk factors associated with DS, 2) to evaluate the severity of DS according to Newton's classification, and 3) to investigate the association between the presence of non-albicans Candida spp. (NAC) or mixed Candida spp. and the severity of DS. Study Design. Eighty-two patients with Candida-positive DS have undergone 1) filling in the interview questionnaire, 2) clinical examination, and 3) microbiologic examination. Results. A total of 113 Candida spp. isolates were obtained from Candida-positive DS patients: C. albicans (as a single species) in 47/82 (57%) patients (study group A [SG_A]) and NAC/mixed Candida spp. in 35/82 (43%) patients (SG_B). Univariate logistic regression analysis showed that older age, longer age of the mandibular denture, and ex-smoker status were associated with SG_A. A multivariate model revealed no significant predictor of DS severity. Patients from SG_A were 3 times as likely to have DS type I, while patients from SG_B were 4.9 times as likely to have DS type III. Conclusions. Our results show the association between type III of DS (by Newton's classification) and the presence of NAC or mixed Candida spp. in denture wearers.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - The severity of denture stomatitis as related to risk factors and different Candida spp.
VL  - 126
IS  - 1
SP  - 41
EP  - 47
DO  - 10.1016/j.oooo.2018.03.003
ER  - 

@article{
author = "Perić, Mirjana and Živković, Rade and Milić-Lemić, Aleksandra and Radunović, Milena and Miličić, Biljana and Arsić-Arsenijević, Valentina",
year = "2018",
abstract = "Objectives. 1) To select patients with Candida-related denture stomatitis (DS) and to study possible risk factors associated with DS, 2) to evaluate the severity of DS according to Newton's classification, and 3) to investigate the association between the presence of non-albicans Candida spp. (NAC) or mixed Candida spp. and the severity of DS. Study Design. Eighty-two patients with Candida-positive DS have undergone 1) filling in the interview questionnaire, 2) clinical examination, and 3) microbiologic examination. Results. A total of 113 Candida spp. isolates were obtained from Candida-positive DS patients: C. albicans (as a single species) in 47/82 (57%) patients (study group A [SG_A]) and NAC/mixed Candida spp. in 35/82 (43%) patients (SG_B). Univariate logistic regression analysis showed that older age, longer age of the mandibular denture, and ex-smoker status were associated with SG_A. A multivariate model revealed no significant predictor of DS severity. Patients from SG_A were 3 times as likely to have DS type I, while patients from SG_B were 4.9 times as likely to have DS type III. Conclusions. Our results show the association between type III of DS (by Newton's classification) and the presence of NAC or mixed Candida spp. in denture wearers.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "The severity of denture stomatitis as related to risk factors and different Candida spp.",
volume = "126",
number = "1",
pages = "41-47",
doi = "10.1016/j.oooo.2018.03.003"
}

Perić, M., Živković, R., Milić-Lemić, A., Radunović, M., Miličić, B.,& Arsić-Arsenijević, V.. (2018). The severity of denture stomatitis as related to risk factors and different Candida spp.. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 126(1), 41-47.
https://doi.org/10.1016/j.oooo.2018.03.003

Perić M, Živković R, Milić-Lemić A, Radunović M, Miličić B, Arsić-Arsenijević V. The severity of denture stomatitis as related to risk factors and different Candida spp.. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2018;126(1):41-47.
doi:10.1016/j.oooo.2018.03.003 .

Perić, Mirjana, Živković, Rade, Milić-Lemić, Aleksandra, Radunović, Milena, Miličić, Biljana, Arsić-Arsenijević, Valentina, "The severity of denture stomatitis as related to risk factors and different Candida spp." in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 126, no. 1 (2018):41-47,
https://doi.org/10.1016/j.oooo.2018.03.003 . .

TY  - JOUR
AU  - Ivošević, Tjasa
AU  - Miličić, Biljana
AU  - Dimitrijević, Milovan
AU  - Ivanović, Branislava
AU  - Pavlović, Aleksandar
AU  - Stojanović, Marina
AU  - Lakicević, Mirko
AU  - Stevanović, Ksenija
AU  - Kalezić, Nevena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2307
AB  - Intraoperative bradycardia (IOB) is one of the most common cardiac arrhythmias observed in clinical anaesthetic practice. Controlled hypotension, as a strategy of lowering patient's blood pressure during anesthesia has been practiced for decades in head and neck surgery. The aim of our study was to determine the incidence and the risk factors for intraoperative bradycardia in maxillofacial, ear, nose and throat surgery, as well as to determine whether controlled hypotension affects the occurrence of IOB. The retrospective study included 2304 patients who underwent maxillofacial, ear, nose or throat surgery. We studied the influence of: sex, age, comorbidity, type of surgery, duration of anesthesia and controlled hypotension on the occurrence of IOB. IOB was registered in 473 patients (20.5%). Patients with controlled hypotension had IOB significantly more often than patients without controlled hypotension (33.9 vs 15.1%) (p = 0.000). The significant predictors of IOB were: age (OR = 1.158; 95% CI = 1.068-1.256; p = 0.000), sex (OR = 0.786; 95% CI = 0.623-0.993; p = 0.043), ischemic heart disease (OR = 2.016; 95% CI = 1.182-3.441; p = 0.010); ear surgery (OR = 1.593; 95% CI = 1.232-2.060; p = 0.000), anesthesia duration, (OR = 1.006; 95% CI = 1.004-1.007; p = 0.000) and controlled hypotension (OR = 2.204; 95% CI = 1.761-2.758; p = 0.000). IOB is common in maxillofacial, ear, nose and throat surgery, particularly in male, older age and patients with ishemic heart disease. The ear surgery, longer anesthesia duration and controlled hypotension raise the risk for occurrence of IOB.
PB  - Springer, New York
T2  - European Archives of Oto-Rhino-Laryngology
T1  - Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery
VL  - 275
IS  - 2
SP  - 579
EP  - 586
DO  - 10.1007/s00405-017-4837-8
ER  - 

@article{
author = "Ivošević, Tjasa and Miličić, Biljana and Dimitrijević, Milovan and Ivanović, Branislava and Pavlović, Aleksandar and Stojanović, Marina and Lakicević, Mirko and Stevanović, Ksenija and Kalezić, Nevena",
year = "2018",
abstract = "Intraoperative bradycardia (IOB) is one of the most common cardiac arrhythmias observed in clinical anaesthetic practice. Controlled hypotension, as a strategy of lowering patient's blood pressure during anesthesia has been practiced for decades in head and neck surgery. The aim of our study was to determine the incidence and the risk factors for intraoperative bradycardia in maxillofacial, ear, nose and throat surgery, as well as to determine whether controlled hypotension affects the occurrence of IOB. The retrospective study included 2304 patients who underwent maxillofacial, ear, nose or throat surgery. We studied the influence of: sex, age, comorbidity, type of surgery, duration of anesthesia and controlled hypotension on the occurrence of IOB. IOB was registered in 473 patients (20.5%). Patients with controlled hypotension had IOB significantly more often than patients without controlled hypotension (33.9 vs 15.1%) (p = 0.000). The significant predictors of IOB were: age (OR = 1.158; 95% CI = 1.068-1.256; p = 0.000), sex (OR = 0.786; 95% CI = 0.623-0.993; p = 0.043), ischemic heart disease (OR = 2.016; 95% CI = 1.182-3.441; p = 0.010); ear surgery (OR = 1.593; 95% CI = 1.232-2.060; p = 0.000), anesthesia duration, (OR = 1.006; 95% CI = 1.004-1.007; p = 0.000) and controlled hypotension (OR = 2.204; 95% CI = 1.761-2.758; p = 0.000). IOB is common in maxillofacial, ear, nose and throat surgery, particularly in male, older age and patients with ishemic heart disease. The ear surgery, longer anesthesia duration and controlled hypotension raise the risk for occurrence of IOB.",
publisher = "Springer, New York",
journal = "European Archives of Oto-Rhino-Laryngology",
title = "Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery",
volume = "275",
number = "2",
pages = "579-586",
doi = "10.1007/s00405-017-4837-8"
}

Ivošević, T., Miličić, B., Dimitrijević, M., Ivanović, B., Pavlović, A., Stojanović, M., Lakicević, M., Stevanović, K.,& Kalezić, N.. (2018). Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery. in European Archives of Oto-Rhino-Laryngology
Springer, New York., 275(2), 579-586.
https://doi.org/10.1007/s00405-017-4837-8

Ivošević T, Miličić B, Dimitrijević M, Ivanović B, Pavlović A, Stojanović M, Lakicević M, Stevanović K, Kalezić N. Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery. in European Archives of Oto-Rhino-Laryngology. 2018;275(2):579-586.
doi:10.1007/s00405-017-4837-8 .

Ivošević, Tjasa, Miličić, Biljana, Dimitrijević, Milovan, Ivanović, Branislava, Pavlović, Aleksandar, Stojanović, Marina, Lakicević, Mirko, Stevanović, Ksenija, Kalezić, Nevena, "Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery" in European Archives of Oto-Rhino-Laryngology, 275, no. 2 (2018):579-586,
https://doi.org/10.1007/s00405-017-4837-8 . .

TY  - JOUR
AU  - Atanasijević, Tatjana
AU  - Popović, Vesna
AU  - Puzović, Dragana
AU  - Miličić, Biljana
AU  - Mihailović, Zoran
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2347
AB  - Introduction/Objective The purpose of this retrospective study was to assess carboxyhemoglobin (HbCO) concentration in all autopsy cases of fire and non-fire victims - all those who have been suspected to be under the influence of carbon monoxide (CO) in the Belgrade area during a 15-year period (1990-2005). Methods Correlations between the concentration of HbCO, circumstances of death, vital signs, and prior health conditions, smoking and history of alcohol-abuse, have been particularly analyzed in 192 autopsy cases. Results The investigation included 52 (27%) females and 140 (73%) males, their average age being 50.78 years. CO poisoning has been established as the cause of death in 74 cases (38%). The manner of death in 170 cases (89%) was an accident, in eight (3%) suicide, in two (1%) murder, in 11 (6%) natural death, and in one case the manner of death hasn't been established. Such distribution of the manner of death differentiates this study from others of similar type, and it is conditioned by the specificity of life in this region. Conclusion The predictors of a high HbCO concentration are the sex, cause of death, manner of death, soot aspiration, lower-degree burns. According to the results, we profiled a typical victim of CO poisoning.
AB  - Uvod/Cilj Cilj retrospektivne studije bio je određivanje koncentracije karboksihemoglobina (HbCO) u svim slučajevima žrtava iz požara i onih koji nisu u vezi sa njim, na području Beograda, u periodu 1990-2005, odnosno svih sluačajeva za koje se sumnjalo da su bili izloženi ugljen-monoksidu (SO). Metode U 192 slučaja obdukcije posebno su analizirane: korelacija između koncentracije HbCO, okolnosti umiranja, vitalnih reakcija, prethodnog zdravstvenog stanja, pušenja i zloupotrebe alkohola. Rezultati Ispitivanje je obuhvatilo 52 (27%) žene i 140 (73%) muškaraca prosečne starosti 50,78 godina. Trovanje SO je utvrđeno kao uzrok smrti u 74 slučaja (38%). U 170 slučajeva (89%) radilo se o zadesima, u 8 (3%) o samoubistvima, u 2 (1%) o ubistvima. U 11 slučajeva (6%) reč je bilo o prirodnoj smrti, dok u jednom slučaju uzrok smrti nije ustanovljen. Ovakva raspodela diferencira ovu studiju od sličnih i uslovljena je specifičnostima života u regionu. Zaključak Prediktori visoke koncentracije HbCO su pol, uzrok smrti, način smrti, aspiracija čađi, stepen izgorevanja. Na osnovu rezultata napravljen je profil žrtve trovanja SO.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The value of the post mortem analysis of carboxyhemoglobin concentration in the blood: A 15-year study
T1  - Značaj postmortalne analize karboksihemoglobina u krvi - petnaestogodišnja studija
VL  - 146
IS  - 7-8
SP  - 428
EP  - 432
DO  - 10.2298/SARH170802182A
ER  - 

@article{
author = "Atanasijević, Tatjana and Popović, Vesna and Puzović, Dragana and Miličić, Biljana and Mihailović, Zoran",
year = "2018",
abstract = "Introduction/Objective The purpose of this retrospective study was to assess carboxyhemoglobin (HbCO) concentration in all autopsy cases of fire and non-fire victims - all those who have been suspected to be under the influence of carbon monoxide (CO) in the Belgrade area during a 15-year period (1990-2005). Methods Correlations between the concentration of HbCO, circumstances of death, vital signs, and prior health conditions, smoking and history of alcohol-abuse, have been particularly analyzed in 192 autopsy cases. Results The investigation included 52 (27%) females and 140 (73%) males, their average age being 50.78 years. CO poisoning has been established as the cause of death in 74 cases (38%). The manner of death in 170 cases (89%) was an accident, in eight (3%) suicide, in two (1%) murder, in 11 (6%) natural death, and in one case the manner of death hasn't been established. Such distribution of the manner of death differentiates this study from others of similar type, and it is conditioned by the specificity of life in this region. Conclusion The predictors of a high HbCO concentration are the sex, cause of death, manner of death, soot aspiration, lower-degree burns. According to the results, we profiled a typical victim of CO poisoning., Uvod/Cilj Cilj retrospektivne studije bio je određivanje koncentracije karboksihemoglobina (HbCO) u svim slučajevima žrtava iz požara i onih koji nisu u vezi sa njim, na području Beograda, u periodu 1990-2005, odnosno svih sluačajeva za koje se sumnjalo da su bili izloženi ugljen-monoksidu (SO). Metode U 192 slučaja obdukcije posebno su analizirane: korelacija između koncentracije HbCO, okolnosti umiranja, vitalnih reakcija, prethodnog zdravstvenog stanja, pušenja i zloupotrebe alkohola. Rezultati Ispitivanje je obuhvatilo 52 (27%) žene i 140 (73%) muškaraca prosečne starosti 50,78 godina. Trovanje SO je utvrđeno kao uzrok smrti u 74 slučaja (38%). U 170 slučajeva (89%) radilo se o zadesima, u 8 (3%) o samoubistvima, u 2 (1%) o ubistvima. U 11 slučajeva (6%) reč je bilo o prirodnoj smrti, dok u jednom slučaju uzrok smrti nije ustanovljen. Ovakva raspodela diferencira ovu studiju od sličnih i uslovljena je specifičnostima života u regionu. Zaključak Prediktori visoke koncentracije HbCO su pol, uzrok smrti, način smrti, aspiracija čađi, stepen izgorevanja. Na osnovu rezultata napravljen je profil žrtve trovanja SO.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The value of the post mortem analysis of carboxyhemoglobin concentration in the blood: A 15-year study, Značaj postmortalne analize karboksihemoglobina u krvi - petnaestogodišnja studija",
volume = "146",
number = "7-8",
pages = "428-432",
doi = "10.2298/SARH170802182A"
}

Atanasijević, T., Popović, V., Puzović, D., Miličić, B.,& Mihailović, Z.. (2018). The value of the post mortem analysis of carboxyhemoglobin concentration in the blood: A 15-year study. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 146(7-8), 428-432.
https://doi.org/10.2298/SARH170802182A

Atanasijević T, Popović V, Puzović D, Miličić B, Mihailović Z. The value of the post mortem analysis of carboxyhemoglobin concentration in the blood: A 15-year study. in Srpski arhiv za celokupno lekarstvo. 2018;146(7-8):428-432.
doi:10.2298/SARH170802182A .

Atanasijević, Tatjana, Popović, Vesna, Puzović, Dragana, Miličić, Biljana, Mihailović, Zoran, "The value of the post mortem analysis of carboxyhemoglobin concentration in the blood: A 15-year study" in Srpski arhiv za celokupno lekarstvo, 146, no. 7-8 (2018):428-432,
https://doi.org/10.2298/SARH170802182A . .

TY  - JOUR
AU  - Lugonja, N. M.
AU  - Stanković, D. M.
AU  - Miličić, Biljana
AU  - Spasić, S. D.
AU  - Marinković, V.
AU  - Vrvić, M. M.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2340
AB  - The electrochemical techniques were used to determine the total antioxidant capacity of breast milks and the results were compared with a commonly used spectrophotometric (2,2-diphenyl-1-picrylhydrazyl, DPPH) method. Breast milk from mothers of preterm infants was monitored in three lactation phases and after storage of expressed milk by monitoring changes in the total antioxidant capacity over a two year period. Statistical analysis showed there was no significant difference between the ability of the three methods to detect changes in breast milk after storage. Either of the electrochemical techniques studied could be successfully used to replace the time-consuming spectrophotometric method and can be applied to clinical trials.
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Electrochemical monitoring of the breast milk quality
VL  - 240
SP  - 567
EP  - 572
DO  - 10.1016/j.foodchem.2017.07.164
ER  - 

@article{
author = "Lugonja, N. M. and Stanković, D. M. and Miličić, Biljana and Spasić, S. D. and Marinković, V. and Vrvić, M. M.",
year = "2018",
abstract = "The electrochemical techniques were used to determine the total antioxidant capacity of breast milks and the results were compared with a commonly used spectrophotometric (2,2-diphenyl-1-picrylhydrazyl, DPPH) method. Breast milk from mothers of preterm infants was monitored in three lactation phases and after storage of expressed milk by monitoring changes in the total antioxidant capacity over a two year period. Statistical analysis showed there was no significant difference between the ability of the three methods to detect changes in breast milk after storage. Either of the electrochemical techniques studied could be successfully used to replace the time-consuming spectrophotometric method and can be applied to clinical trials.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Electrochemical monitoring of the breast milk quality",
volume = "240",
pages = "567-572",
doi = "10.1016/j.foodchem.2017.07.164"
}

Lugonja, N. M., Stanković, D. M., Miličić, B., Spasić, S. D., Marinković, V.,& Vrvić, M. M.. (2018). Electrochemical monitoring of the breast milk quality. in Food Chemistry
Elsevier Sci Ltd, Oxford., 240, 567-572.
https://doi.org/10.1016/j.foodchem.2017.07.164

Lugonja NM, Stanković DM, Miličić B, Spasić SD, Marinković V, Vrvić MM. Electrochemical monitoring of the breast milk quality. in Food Chemistry. 2018;240:567-572.
doi:10.1016/j.foodchem.2017.07.164 .

Lugonja, N. M., Stanković, D. M., Miličić, Biljana, Spasić, S. D., Marinković, V., Vrvić, M. M., "Electrochemical monitoring of the breast milk quality" in Food Chemistry, 240 (2018):567-572,
https://doi.org/10.1016/j.foodchem.2017.07.164 . .

TY  - JOUR
AU  - Stojanović, Marina
AU  - Kalezić, Nevena
AU  - Miličić, Biljana
AU  - Tosković, Anka R.
AU  - Stevanović, Ksenija
AU  - Antonijević, Vesna
AU  - Lakićević, Mirko
AU  - Bagi, Bojan
AU  - Živaljević, Vladan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2328
AB  - Introduction/Objective Intraoperative variations in blood pressure and/or cardiac dysrhythmias (IOVBP/CD) represent one of the most common causes of morbidity and mortality in surgical patients. The aim of the study was to determine the incidence and risk factors for IOVBP/CD in thyroid surgery patients with comorbidities. Methods The study included 1,252 euthyroid patients with ASA 2 and ASA 3 status (American Society of Anesthesiologists - physical status classification) who underwent thyroid surgery. The following risk factors were examined: sex, age, body mass index (BMI), ASA status, admission diagnoses, type of operation, duration of surgery, time under general anesthesia, difficult intubation of trachea, and coexisting diseases - hypertension, cardiomyopathy, cardiac arrhythmias, angina pectoris, diabetes mellitus, kidney disease. The following intraoperative events were recorded: hypertension, severe hypertension, hypotension, and cardiac arrhythmias. We used Pearson χ2 square test, univariate, and multivariate logistic regression for statistical analysis. Results The majority of patients were female (86.3%). In 903 (72.1%) patients IOVBP/CD were detected. The most common problem was intraoperative hypertension (61.4%). Eight risk factors for IOVBP/CD were registered by univariate analysis: advanced age, ASA 3 status, BMI > 25 kg/m2, duration of surgery, time under general anesthesia, hypertension, and cardiomyopathy as a coexisting disease. The multivariate regression model identified three independent predictors for IOVBP/CD: age, hypertension, and cardiomyopathy. Conclusion IOVBP/CD are common in thyroid surgery. The most common is intraoperative hypertension. Older age, hypertension, and cardiomyopathy as a coexisting disease are independent risk factors for IOVBP/CD.
AB  - Uvod/Cilj Intraoperativne varijacije krvnog pritiska i/ ili srčane disritmije (IVKP/SD) jedan su od najčešćih uzročnika morbiditeta i mortaliteta hirurških bolesnika. Cilj studije je bio da ispita učestalost i faktore rizika za pojavu IVKP/SD u tireoidnoj hirurgiji kod bolesnika sa komorbiditetima. Metode Ispitivanje je obuhvatilo 1252 eutireoidna bolesnika ASA 2 i ASA 3 statusa podvrgnutih tireoidnoj hirurgiji. Ispitivan je uticaj sledećih faktora rizika: pol, starost, indeks telesne mase (ITM), ASA status, prijemna dijagnoza, tip operacije, trajanje operacije, trajanje anestezije, otežana intubacija traheje, kao i komorbiditeti: hipertenzija, kardiomiopatija, srčane aritmije, angina pektoris, dijabetes melitus, bolesti bubrega. Registrovani su intraoperativno: hipertenzija, hipertenzivna kriza, hipotenzija i srčane aritmije. Korišćen je Pirsonov χ2-test, univarijantna i multivarijantna regresiona analiza za statističku obradu podataka. Rezultati Većinu bolesnika su činile žene (86,3%). IVKP/ SD su registrovani kod 903 (72,1%) bolesnika. Najčešći poremećaj je bila intraoperativna hipertenzija - 61,4%. Univarijantnom analizom je registrovano sedam faktora rizika za pojavu IVKP/SD: godine života, ASA 3 status, ITM > 25 kg/m2, trajanje hirurgije, trajanje anestezije, hipertenzija i kardiomiopatija kao komorbiditet. Multivarijantnom regresionom analizom izdvojila su se tri nezavisna prediktora pojave IVKP/SD: godine starosti, hipertenzija i kardiomiopatija. Zaključak IVKP/SD su česte u tireoidnoj hirurgiji. Najčešća je intraoperativna hipertenzija. Starije životno doba, hipertenzija i kardiomiopatija kao koegzistirajuće bolesti su nezavisni faktori rizika za pojavu IVKP/SD.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Risk factors for intraoperative variations in blood pressure and cardiac dysrhythmia during thyroid surgery
T1  - Faktori rizika za pojavu intraoperativnih varijacija vrednosti krvnog pritiska i srčanih disritmija tokom tireoidne hirurgije
VL  - 146
IS  - 3-4
SP  - 163
EP  - 168
DO  - 10.2298/SARH170522156S
ER  - 

@article{
author = "Stojanović, Marina and Kalezić, Nevena and Miličić, Biljana and Tosković, Anka R. and Stevanović, Ksenija and Antonijević, Vesna and Lakićević, Mirko and Bagi, Bojan and Živaljević, Vladan",
year = "2018",
abstract = "Introduction/Objective Intraoperative variations in blood pressure and/or cardiac dysrhythmias (IOVBP/CD) represent one of the most common causes of morbidity and mortality in surgical patients. The aim of the study was to determine the incidence and risk factors for IOVBP/CD in thyroid surgery patients with comorbidities. Methods The study included 1,252 euthyroid patients with ASA 2 and ASA 3 status (American Society of Anesthesiologists - physical status classification) who underwent thyroid surgery. The following risk factors were examined: sex, age, body mass index (BMI), ASA status, admission diagnoses, type of operation, duration of surgery, time under general anesthesia, difficult intubation of trachea, and coexisting diseases - hypertension, cardiomyopathy, cardiac arrhythmias, angina pectoris, diabetes mellitus, kidney disease. The following intraoperative events were recorded: hypertension, severe hypertension, hypotension, and cardiac arrhythmias. We used Pearson χ2 square test, univariate, and multivariate logistic regression for statistical analysis. Results The majority of patients were female (86.3%). In 903 (72.1%) patients IOVBP/CD were detected. The most common problem was intraoperative hypertension (61.4%). Eight risk factors for IOVBP/CD were registered by univariate analysis: advanced age, ASA 3 status, BMI > 25 kg/m2, duration of surgery, time under general anesthesia, hypertension, and cardiomyopathy as a coexisting disease. The multivariate regression model identified three independent predictors for IOVBP/CD: age, hypertension, and cardiomyopathy. Conclusion IOVBP/CD are common in thyroid surgery. The most common is intraoperative hypertension. Older age, hypertension, and cardiomyopathy as a coexisting disease are independent risk factors for IOVBP/CD., Uvod/Cilj Intraoperativne varijacije krvnog pritiska i/ ili srčane disritmije (IVKP/SD) jedan su od najčešćih uzročnika morbiditeta i mortaliteta hirurških bolesnika. Cilj studije je bio da ispita učestalost i faktore rizika za pojavu IVKP/SD u tireoidnoj hirurgiji kod bolesnika sa komorbiditetima. Metode Ispitivanje je obuhvatilo 1252 eutireoidna bolesnika ASA 2 i ASA 3 statusa podvrgnutih tireoidnoj hirurgiji. Ispitivan je uticaj sledećih faktora rizika: pol, starost, indeks telesne mase (ITM), ASA status, prijemna dijagnoza, tip operacije, trajanje operacije, trajanje anestezije, otežana intubacija traheje, kao i komorbiditeti: hipertenzija, kardiomiopatija, srčane aritmije, angina pektoris, dijabetes melitus, bolesti bubrega. Registrovani su intraoperativno: hipertenzija, hipertenzivna kriza, hipotenzija i srčane aritmije. Korišćen je Pirsonov χ2-test, univarijantna i multivarijantna regresiona analiza za statističku obradu podataka. Rezultati Većinu bolesnika su činile žene (86,3%). IVKP/ SD su registrovani kod 903 (72,1%) bolesnika. Najčešći poremećaj je bila intraoperativna hipertenzija - 61,4%. Univarijantnom analizom je registrovano sedam faktora rizika za pojavu IVKP/SD: godine života, ASA 3 status, ITM > 25 kg/m2, trajanje hirurgije, trajanje anestezije, hipertenzija i kardiomiopatija kao komorbiditet. Multivarijantnom regresionom analizom izdvojila su se tri nezavisna prediktora pojave IVKP/SD: godine starosti, hipertenzija i kardiomiopatija. Zaključak IVKP/SD su česte u tireoidnoj hirurgiji. Najčešća je intraoperativna hipertenzija. Starije životno doba, hipertenzija i kardiomiopatija kao koegzistirajuće bolesti su nezavisni faktori rizika za pojavu IVKP/SD.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Risk factors for intraoperative variations in blood pressure and cardiac dysrhythmia during thyroid surgery, Faktori rizika za pojavu intraoperativnih varijacija vrednosti krvnog pritiska i srčanih disritmija tokom tireoidne hirurgije",
volume = "146",
number = "3-4",
pages = "163-168",
doi = "10.2298/SARH170522156S"
}

Stojanović, M., Kalezić, N., Miličić, B., Tosković, A. R., Stevanović, K., Antonijević, V., Lakićević, M., Bagi, B.,& Živaljević, V.. (2018). Risk factors for intraoperative variations in blood pressure and cardiac dysrhythmia during thyroid surgery. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 146(3-4), 163-168.
https://doi.org/10.2298/SARH170522156S

Stojanović M, Kalezić N, Miličić B, Tosković AR, Stevanović K, Antonijević V, Lakićević M, Bagi B, Živaljević V. Risk factors for intraoperative variations in blood pressure and cardiac dysrhythmia during thyroid surgery. in Srpski arhiv za celokupno lekarstvo. 2018;146(3-4):163-168.
doi:10.2298/SARH170522156S .

Stojanović, Marina, Kalezić, Nevena, Miličić, Biljana, Tosković, Anka R., Stevanović, Ksenija, Antonijević, Vesna, Lakićević, Mirko, Bagi, Bojan, Živaljević, Vladan, "Risk factors for intraoperative variations in blood pressure and cardiac dysrhythmia during thyroid surgery" in Srpski arhiv za celokupno lekarstvo, 146, no. 3-4 (2018):163-168,
https://doi.org/10.2298/SARH170522156S . .

TY  - JOUR
AU  - Cvetković, Ana
AU  - Kalezić, Nevena
AU  - Miličić, Biljana
AU  - Nikolić, Srđan
AU  - Zegarac, Milan
AU  - Gavrilović, Dušica
AU  - Stojiljković, Dejan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2322
AB  - Purpose: The purpose of this study was to compare two groups in postoperative recovery, whether there were any complications and whether the length of their hospital stay differed. One group received intraoperatively a combination of crystalloids and a small colloid dose, while the other group received only the crystalloids intraoperatively. Methods: This randomized prospective study included 80 patients with colorectal cancer prepared for major elective colorectal surgery. The patients were randomly assigned to either the control group (CG) which received only crystalloid solutions intraoperatively or to the research group (RG) which received a combination of colloid and crystalloid solutions. Regional and general endotracheal anesthesia techniques were combined in all patients. Goal-directed fluid therapy was administered to patients in both groups. After extubation, patients were transferred in the Intensive Care Unit (ICU). We measured the administered fluids, fluid balance, the volume of received red packed cells (RPC) and fresh frozen plasma (FFP). Recorded were the first bowel movement, the first flatus, the tolerance on oral food, complications by Clavian-Dindo classification, days of patient's recovery delay in the ICU, Surgery Department (SD) and the total length of hospital stay (LOS). Results: Statistically significant differences were present in all parameters of postoperative recovery. RG patients showed better results relative to the CG patients. RG patients were faster in restoring bowel movement and peristalsis, get the first postoperative stool and re-acquire oral food tolerance. According to the Clavian-Dindo classification of complications, no significant difference between these two groups was noted. Conclusions: Goal-directed colloid-crystalloid therapy significantly improved postoperative recovery.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery
VL  - 23
IS  - 5
SP  - 1369
EP  - 1379
UR  - https://hdl.handle.net/21.15107/rcub_smile_2322
ER  - 

@article{
author = "Cvetković, Ana and Kalezić, Nevena and Miličić, Biljana and Nikolić, Srđan and Zegarac, Milan and Gavrilović, Dušica and Stojiljković, Dejan",
year = "2018",
abstract = "Purpose: The purpose of this study was to compare two groups in postoperative recovery, whether there were any complications and whether the length of their hospital stay differed. One group received intraoperatively a combination of crystalloids and a small colloid dose, while the other group received only the crystalloids intraoperatively. Methods: This randomized prospective study included 80 patients with colorectal cancer prepared for major elective colorectal surgery. The patients were randomly assigned to either the control group (CG) which received only crystalloid solutions intraoperatively or to the research group (RG) which received a combination of colloid and crystalloid solutions. Regional and general endotracheal anesthesia techniques were combined in all patients. Goal-directed fluid therapy was administered to patients in both groups. After extubation, patients were transferred in the Intensive Care Unit (ICU). We measured the administered fluids, fluid balance, the volume of received red packed cells (RPC) and fresh frozen plasma (FFP). Recorded were the first bowel movement, the first flatus, the tolerance on oral food, complications by Clavian-Dindo classification, days of patient's recovery delay in the ICU, Surgery Department (SD) and the total length of hospital stay (LOS). Results: Statistically significant differences were present in all parameters of postoperative recovery. RG patients showed better results relative to the CG patients. RG patients were faster in restoring bowel movement and peristalsis, get the first postoperative stool and re-acquire oral food tolerance. According to the Clavian-Dindo classification of complications, no significant difference between these two groups was noted. Conclusions: Goal-directed colloid-crystalloid therapy significantly improved postoperative recovery.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery",
volume = "23",
number = "5",
pages = "1369-1379",
url = "https://hdl.handle.net/21.15107/rcub_smile_2322"
}

Cvetković, A., Kalezić, N., Miličić, B., Nikolić, S., Zegarac, M., Gavrilović, D.,& Stojiljković, D.. (2018). The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(5), 1369-1379.
https://hdl.handle.net/21.15107/rcub_smile_2322

Cvetković A, Kalezić N, Miličić B, Nikolić S, Zegarac M, Gavrilović D, Stojiljković D. The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery. in Journal of BUON. 2018;23(5):1369-1379.
https://hdl.handle.net/21.15107/rcub_smile_2322 .

Cvetković, Ana, Kalezić, Nevena, Miličić, Biljana, Nikolić, Srđan, Zegarac, Milan, Gavrilović, Dušica, Stojiljković, Dejan, "The impact of different infusion solutions on postoperative recovery following colorectal cancer surgery" in Journal of BUON, 23, no. 5 (2018):1369-1379,
https://hdl.handle.net/21.15107/rcub_smile_2322 .

TY  - CONF
AU  - Miloševski-Lomić, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Basta-Jovanović, Gordana
AU  - Kostić, Mirjana
AU  - Miličić, Biljana
AU  - Paripović, Dušan
AU  - Nikolovski, SrDan
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Gojović, Ivana
AU  - Cvetković, Mirjana
AU  - Kruscić, Divna
AU  - Peco-Antić, Amira
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2320
PB  - Springer, New York
C3  - Pediatric Nephrology
T1  - Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies
VL  - 33
IS  - 10
SP  - 1873
EP  - 1873
UR  - https://hdl.handle.net/21.15107/rcub_smile_2320
ER  - 

@conference{
author = "Miloševski-Lomić, Gordana and Radojević-Škodrić, Sanja and Basta-Jovanović, Gordana and Kostić, Mirjana and Miličić, Biljana and Paripović, Dušan and Nikolovski, SrDan and Spasojević-Dimitrijeva, Brankica and Gojović, Ivana and Cvetković, Mirjana and Kruscić, Divna and Peco-Antić, Amira",
year = "2018",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies",
volume = "33",
number = "10",
pages = "1873-1873",
url = "https://hdl.handle.net/21.15107/rcub_smile_2320"
}

Miloševski-Lomić, G., Radojević-Škodrić, S., Basta-Jovanović, G., Kostić, M., Miličić, B., Paripović, D., Nikolovski, S., Spasojević-Dimitrijeva, B., Gojović, I., Cvetković, M., Kruscić, D.,& Peco-Antić, A.. (2018). Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies. in Pediatric Nephrology
Springer, New York., 33(10), 1873-1873.
https://hdl.handle.net/21.15107/rcub_smile_2320

Miloševski-Lomić G, Radojević-Škodrić S, Basta-Jovanović G, Kostić M, Miličić B, Paripović D, Nikolovski S, Spasojević-Dimitrijeva B, Gojović I, Cvetković M, Kruscić D, Peco-Antić A. Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies. in Pediatric Nephrology. 2018;33(10):1873-1873.
https://hdl.handle.net/21.15107/rcub_smile_2320 .

Miloševski-Lomić, Gordana, Radojević-Škodrić, Sanja, Basta-Jovanović, Gordana, Kostić, Mirjana, Miličić, Biljana, Paripović, Dušan, Nikolovski, SrDan, Spasojević-Dimitrijeva, Brankica, Gojović, Ivana, Cvetković, Mirjana, Kruscić, Divna, Peco-Antić, Amira, "Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies" in Pediatric Nephrology, 33, no. 10 (2018):1873-1873,
https://hdl.handle.net/21.15107/rcub_smile_2320 .

TY  - JOUR
AU  - Milovanović, Tamara
AU  - Copertino, Ana
AU  - Boričić, Ivan
AU  - Miličić, Biljana
AU  - Pavlović-Marković, Aleksandra
AU  - Krstić, Miodrag
AU  - Matović, Vera
AU  - Popović, Dušan Đ.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2294
AB  - In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p  lt  0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures.
AB  - Prethodnih decenija otkrivene su neinvanzivne metode za procenu i praćenje fibroze jetre kod hroničnih bolesti jetre. Cilj ove studije bila je procena dijagnostičke preciznosti neinvanzivnih metoda za određivanje fibroze jetre [tranzijentna elastografija (TE) i biohemijski markeri], pri čemu je kao zlatni standard korišćena biopsija jetre kod bolesnika sa primarnom bilijarnom cirozom. Metode. U studiju su bila uključena 122 bolesnika kod kojih su istog dana urađene biohemijske analize i biopsija jetre, a mesec dana kasnije urađena je TE. Za procenu fibroze jetre korišćen je METAVIR skor, a sve preparate biopsija proverio je jedan patolog. APRI skor - odnos aspartat aminotransferaze (AST) i trombocita, Forns indeks, odnos AST i alanin transaminaze (ALT) i TE poređene su sa stepenom fiboze jetre dobijene na osnovu biopsija jetre u cilju dobijanja najboljeg neinvanzivnog markera u proceni fibroze jetre. Rezultati. Dokazana je statistička značajnost (p  lt  0.05) za APRI skor, Forns indeks i TE za procenu stepena fibroze jetre. TE je imala najbolji dijagnostički učinak u poređenju sa ostalim markerima koje smo istraživali. Optimalne granične vrednosti za TE bile su 4.25 i 5.9 kPa za dijagnozu fibroze jetre i razlikovanje slabe/umerene i uznapredovale fibroze. Površina ispod krive operativnih karakteristka (AUROC) za TE bila je 0.963 i 0.865. Zaključak. Na osnovu rezultata ove studije proizilazili su APRI skor, Forns indeks i TE adekvatni dijagnostički markeri fibroze jetre kod bolesnika sa primarnom biijarnom cirozom, ali je TE najsenzitivniji i najspecifičniji parametar. Koristeći neinvanzivne parametre i metode u svakodnevnoj kliničkoj praksi može se smanjiti, ali ne i potpuno izbaciti, potreba za invanzivnim dijagnostičkim procedurama.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis
T1  - Tranzijentna elastografija u neinvazivnoj proceni fibroze jetre kod bolesnika sa primarnom bilijarnom cirozom
VL  - 75
IS  - 4
SP  - 374
EP  - 379
DO  - 10.2298/VSP160409337A
ER  - 

@article{
author = "Milovanović, Tamara and Copertino, Ana and Boričić, Ivan and Miličić, Biljana and Pavlović-Marković, Aleksandra and Krstić, Miodrag and Matović, Vera and Popović, Dušan Đ.",
year = "2018",
abstract = "In recent decades noninvasive methods for the assessment and monitoring of liver fibrosis have been developed and evaluated in numerous chronic liver diseases. The aim of this study was to evaluate the diagnostic accuracy of noninvasive markers for fibrosis assessment transient elastography (TE) and biochemical markers using liver biopsy as reference in patients with primary biliary cirrhosis (PBC). Methods. One hundred and twenty-two patients underwent both liver biopsy and blood tests on the same day and TE in a month following the biopsy and the tests. Liver biopsies were reviewed by a single pathologist using the METAVIR scoring system for assessment of liver fibrosis. Aspartate aminotransferase (AST), platelet ratio index (APRI), Forns scores, AST and alanine transaminase (ALT) ratio and TE were compared with liver fibrosis stage in order to determine the best noninvasive marker of liver fibrosis. Results. There was a statistically significant difference (p  lt  0.05) for the APRI score, Forns index and TE according to stages of liver fibrosis. TE showed superior diagnostic performance when compared to other surrogate markers of liver fibrosis that were investigated. Optimal cut-off for TE were 4.25 and 5.9 kPa for diagnosing the presence of fibrosis and distinguishing mild/moderate and advanced stages of fibrosis respectively. The areas under the receiver operating characteristic (AUROC) of TE were 0.963 and 0.865, respectively. Conclusion. Based on our investigation the APRI score, Forns index and TE adequately predict fibrosis stage in patients with primary biliary cirrhosis, but the most sensitive and specific parameter appears to be TE. Using noninvasive markers and methods in the evaluation of patients in daily clinical practice may reduce, but not eliminate, the need for invasive diagnostic procedures., Prethodnih decenija otkrivene su neinvanzivne metode za procenu i praćenje fibroze jetre kod hroničnih bolesti jetre. Cilj ove studije bila je procena dijagnostičke preciznosti neinvanzivnih metoda za određivanje fibroze jetre [tranzijentna elastografija (TE) i biohemijski markeri], pri čemu je kao zlatni standard korišćena biopsija jetre kod bolesnika sa primarnom bilijarnom cirozom. Metode. U studiju su bila uključena 122 bolesnika kod kojih su istog dana urađene biohemijske analize i biopsija jetre, a mesec dana kasnije urađena je TE. Za procenu fibroze jetre korišćen je METAVIR skor, a sve preparate biopsija proverio je jedan patolog. APRI skor - odnos aspartat aminotransferaze (AST) i trombocita, Forns indeks, odnos AST i alanin transaminaze (ALT) i TE poređene su sa stepenom fiboze jetre dobijene na osnovu biopsija jetre u cilju dobijanja najboljeg neinvanzivnog markera u proceni fibroze jetre. Rezultati. Dokazana je statistička značajnost (p  lt  0.05) za APRI skor, Forns indeks i TE za procenu stepena fibroze jetre. TE je imala najbolji dijagnostički učinak u poređenju sa ostalim markerima koje smo istraživali. Optimalne granične vrednosti za TE bile su 4.25 i 5.9 kPa za dijagnozu fibroze jetre i razlikovanje slabe/umerene i uznapredovale fibroze. Površina ispod krive operativnih karakteristka (AUROC) za TE bila je 0.963 i 0.865. Zaključak. Na osnovu rezultata ove studije proizilazili su APRI skor, Forns indeks i TE adekvatni dijagnostički markeri fibroze jetre kod bolesnika sa primarnom biijarnom cirozom, ali je TE najsenzitivniji i najspecifičniji parametar. Koristeći neinvanzivne parametre i metode u svakodnevnoj kliničkoj praksi može se smanjiti, ali ne i potpuno izbaciti, potreba za invanzivnim dijagnostičkim procedurama.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis, Tranzijentna elastografija u neinvazivnoj proceni fibroze jetre kod bolesnika sa primarnom bilijarnom cirozom",
volume = "75",
number = "4",
pages = "374-379",
doi = "10.2298/VSP160409337A"
}

Milovanović, T., Copertino, A., Boričić, I., Miličić, B., Pavlović-Marković, A., Krstić, M., Matović, V.,& Popović, D. Đ.. (2018). Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(4), 374-379.
https://doi.org/10.2298/VSP160409337A

Milovanović T, Copertino A, Boričić I, Miličić B, Pavlović-Marković A, Krstić M, Matović V, Popović DĐ. Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis. in Vojnosanitetski pregled. 2018;75(4):374-379.
doi:10.2298/VSP160409337A .

Milovanović, Tamara, Copertino, Ana, Boričić, Ivan, Miličić, Biljana, Pavlović-Marković, Aleksandra, Krstić, Miodrag, Matović, Vera, Popović, Dušan Đ., "Transient elastography for noninvasive assessment of liver fibrosis in patients with primary biliary cirrhosis" in Vojnosanitetski pregled, 75, no. 4 (2018):374-379,
https://doi.org/10.2298/VSP160409337A . .