TY  - JOUR
AU  - Velicković, Milena
AU  - Pejnović, Nada
AU  - Petrović, Renata
AU  - Mitrović, Slobodanka
AU  - Jeftić, Ilija
AU  - Kanjevac, Tatjana
AU  - Lukić, Aleksandra
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2135
AB  - BACKGROUND: Interleukin-33 (IL-33) is a recently identified cytokine belonging to the IL-1 family and ligand for the IL-1 receptor-related protein ST2. IL-33/ST2 signaling plays a critical role in allergy, autoimmunity, and chronic inflammatory disorders, but its role in the pathogenesis of periapical lesions is unknown. We aimed to investigate the expression patterns of IL-33 and ST2 in human periapical lesions. METHODS: Periapical lesions (n = 36) and healthy periapical tissues (n = 10) were evaluated by immunohistochemistry using antibodies specific for human IL-33 and ST2. Lesion samples were further analyzed by double immunofluorescence to assess IL-33/ST2 co-expression. RESULTS: The numbers of IL-33- and ST2-positive fibroblasts were significantly higher in periapical lesions compared to healthy periapical tissues (both P  lt  0.05), while the numbers of IL-33-and ST2-positive endothelial cells were similar (both P > 0.05). There were no significant differences in the numbers of IL-33-and ST2-positive fibroblasts and endothelial cells between periapical granulomas and radicular cysts (all P > 0.05). Similarly, numbers of ST2-positive mononuclear cells did not differ between periapical granulomas and radicular cysts (P > 0.05). The majority of epithelial cells in radicular cysts were IL-33 positive, while the small proportion of epithelial cells was ST2 positive. Double immunofluorescence analysis revealed IL-33/ST2 co-expression in fibroblasts and endothelial cells. CONCLUSIONS: IL-33 and ST2 are expressed in periapical granulomas and radicular cysts. Increased numbers of IL-33-and ST2-positive fibroblasts in periapical lesions when compared to healthy periapical tissues suggest that IL-33/ST2 signaling may be involved in periapical inflammation and tissue fibrosis.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts
VL  - 45
IS  - 1
SP  - 70
EP  - 76
DO  - 10.1111/jop.12312
ER  - 

@article{
author = "Velicković, Milena and Pejnović, Nada and Petrović, Renata and Mitrović, Slobodanka and Jeftić, Ilija and Kanjevac, Tatjana and Lukić, Aleksandra",
year = "2016",
abstract = "BACKGROUND: Interleukin-33 (IL-33) is a recently identified cytokine belonging to the IL-1 family and ligand for the IL-1 receptor-related protein ST2. IL-33/ST2 signaling plays a critical role in allergy, autoimmunity, and chronic inflammatory disorders, but its role in the pathogenesis of periapical lesions is unknown. We aimed to investigate the expression patterns of IL-33 and ST2 in human periapical lesions. METHODS: Periapical lesions (n = 36) and healthy periapical tissues (n = 10) were evaluated by immunohistochemistry using antibodies specific for human IL-33 and ST2. Lesion samples were further analyzed by double immunofluorescence to assess IL-33/ST2 co-expression. RESULTS: The numbers of IL-33- and ST2-positive fibroblasts were significantly higher in periapical lesions compared to healthy periapical tissues (both P  lt  0.05), while the numbers of IL-33-and ST2-positive endothelial cells were similar (both P > 0.05). There were no significant differences in the numbers of IL-33-and ST2-positive fibroblasts and endothelial cells between periapical granulomas and radicular cysts (all P > 0.05). Similarly, numbers of ST2-positive mononuclear cells did not differ between periapical granulomas and radicular cysts (P > 0.05). The majority of epithelial cells in radicular cysts were IL-33 positive, while the small proportion of epithelial cells was ST2 positive. Double immunofluorescence analysis revealed IL-33/ST2 co-expression in fibroblasts and endothelial cells. CONCLUSIONS: IL-33 and ST2 are expressed in periapical granulomas and radicular cysts. Increased numbers of IL-33-and ST2-positive fibroblasts in periapical lesions when compared to healthy periapical tissues suggest that IL-33/ST2 signaling may be involved in periapical inflammation and tissue fibrosis.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts",
volume = "45",
number = "1",
pages = "70-76",
doi = "10.1111/jop.12312"
}

Velicković, M., Pejnović, N., Petrović, R., Mitrović, S., Jeftić, I., Kanjevac, T.,& Lukić, A.. (2016). Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 45(1), 70-76.
https://doi.org/10.1111/jop.12312

Velicković M, Pejnović N, Petrović R, Mitrović S, Jeftić I, Kanjevac T, Lukić A. Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts. in Journal of Oral Pathology & Medicine. 2016;45(1):70-76.
doi:10.1111/jop.12312 .

Velicković, Milena, Pejnović, Nada, Petrović, Renata, Mitrović, Slobodanka, Jeftić, Ilija, Kanjevac, Tatjana, Lukić, Aleksandra, "Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts" in Journal of Oral Pathology & Medicine, 45, no. 1 (2016):70-76,
https://doi.org/10.1111/jop.12312 . .

TY  - JOUR
AU  - Krstić, Viktor A.
AU  - Milosavljević, Miloš Z.
AU  - Mitrović, Slobodanka
AU  - Azanjac, Goran Lj.
AU  - Knežević, Milan G.
AU  - Konstantinović, Vitomir
AU  - Nedović, Jasmina R.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1739
AB  - Synovial sarcomas are malignant tumors of mesenchymal origin, extremely rarely located in the area of the head and neck. Histologically they can be monophasic, biphasic or poorly differentiated with numerous differential diagnostic dilemmas. A 54-year-old male with synovial sarcoma of the carotid space is presented. The patient refused suggested postoperative radiotherapy and, nine months after the primary surgery, local relapse was verified. Following surgical resection of the local relapse, postoperative radiotherapy treatment was utilized. Ten months after the second surgery, secondary deposits in the lungs were radiographically confirmed, and local recurrence was noticed again. Treatment was continued with symptomatic therapy and eleven months later patient died. Synovial sarcomas of the carotid space are extremely rare, with complex surgical approaches and pathohistological differential diagnostic dilemmas. Diagnosis requires determination of the immunophenotype of the tumor cells, whereas therapy requires an aggressive surgical approach and postoperative radiotherapy.
PB  - Versita, Warsaw
T2  - Central European Journal of Medicine
T1  - Synovial sarcoma of carotid space
VL  - 7
IS  - 4
SP  - 497
EP  - 502
DO  - 10.2478/s11536-012-0004-1
ER  - 

@article{
author = "Krstić, Viktor A. and Milosavljević, Miloš Z. and Mitrović, Slobodanka and Azanjac, Goran Lj. and Knežević, Milan G. and Konstantinović, Vitomir and Nedović, Jasmina R.",
year = "2012",
abstract = "Synovial sarcomas are malignant tumors of mesenchymal origin, extremely rarely located in the area of the head and neck. Histologically they can be monophasic, biphasic or poorly differentiated with numerous differential diagnostic dilemmas. A 54-year-old male with synovial sarcoma of the carotid space is presented. The patient refused suggested postoperative radiotherapy and, nine months after the primary surgery, local relapse was verified. Following surgical resection of the local relapse, postoperative radiotherapy treatment was utilized. Ten months after the second surgery, secondary deposits in the lungs were radiographically confirmed, and local recurrence was noticed again. Treatment was continued with symptomatic therapy and eleven months later patient died. Synovial sarcomas of the carotid space are extremely rare, with complex surgical approaches and pathohistological differential diagnostic dilemmas. Diagnosis requires determination of the immunophenotype of the tumor cells, whereas therapy requires an aggressive surgical approach and postoperative radiotherapy.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Medicine",
title = "Synovial sarcoma of carotid space",
volume = "7",
number = "4",
pages = "497-502",
doi = "10.2478/s11536-012-0004-1"
}

Krstić, V. A., Milosavljević, M. Z., Mitrović, S., Azanjac, G. Lj., Knežević, M. G., Konstantinović, V.,& Nedović, J. R.. (2012). Synovial sarcoma of carotid space. in Central European Journal of Medicine
Versita, Warsaw., 7(4), 497-502.
https://doi.org/10.2478/s11536-012-0004-1

Krstić VA, Milosavljević MZ, Mitrović S, Azanjac GL, Knežević MG, Konstantinović V, Nedović JR. Synovial sarcoma of carotid space. in Central European Journal of Medicine. 2012;7(4):497-502.
doi:10.2478/s11536-012-0004-1 .

Krstić, Viktor A., Milosavljević, Miloš Z., Mitrović, Slobodanka, Azanjac, Goran Lj., Knežević, Milan G., Konstantinović, Vitomir, Nedović, Jasmina R., "Synovial sarcoma of carotid space" in Central European Journal of Medicine, 7, no. 4 (2012):497-502,
https://doi.org/10.2478/s11536-012-0004-1 . .