TY  - JOUR
AU  - Brković, Božidar
AU  - Gardašević, Milka
AU  - Roganović, Jelena
AU  - Jović, N.
AU  - Todorović, L.
AU  - Stojić, Dragica
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1426
AB  - The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects
VL  - 37
IS  - 2
SP  - 149
EP  - 155
DO  - 10.1016/j.ijom.2007.07.019
ER  - 

@article{
author = "Brković, Božidar and Gardašević, Milka and Roganović, Jelena and Jović, N. and Todorović, L. and Stojić, Dragica",
year = "2008",
abstract = "The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 mu g/ml; n = 20) or epinephrine (12.5 mu g/ml; n = 20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine + clonidine were similar to those obtained with lidocaine + epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine + clonidine group and significant increase in heart rate in the lidocaine + epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5) M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine + clonidine combination could be a useful and safe alternative to lidocaine + epinephrine for intraoral infiltration anaesthesia.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects",
volume = "37",
number = "2",
pages = "149-155",
doi = "10.1016/j.ijom.2007.07.019"
}

Brković, B., Gardašević, M., Roganović, J., Jović, N., Todorović, L.,& Stojić, D.. (2008). Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 37(2), 149-155.
https://doi.org/10.1016/j.ijom.2007.07.019

Brković B, Gardašević M, Roganović J, Jović N, Todorović L, Stojić D. Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. in International Journal of Oral & Maxillofacial Surgery. 2008;37(2):149-155.
doi:10.1016/j.ijom.2007.07.019 .

Brković, Božidar, Gardašević, Milka, Roganović, Jelena, Jović, N., Todorović, L., Stojić, Dragica, "Lidocaine plus clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects" in International Journal of Oral & Maxillofacial Surgery, 37, no. 2 (2008):149-155,
https://doi.org/10.1016/j.ijom.2007.07.019 . .

TY  - JOUR
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
AU  - Jovanović, T.
AU  - Todorović, L.
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1330
AB  - Introduction: Recent studies suggest that some viruses, including human cytomegalovirus (CMV), may be involved in the pathogenesis of periapical lesions. Since periapical cysts (PCs) represent the next stage in the evolution of periapical granuloma, it seemed reasonable to investigate the presence of CMV in PCs and any possible relationship between its presence and the clinical features of those cysts, as well as to compare the results obtained with corresponding findings in non-inflammatory lesions, like odontogenic keratocysts (OKCs). Methods: Samples of 33 PCs and 10 OKCs, obtained at the time of surgery, were used for the detection of CMV DNA by polymerase chain reaction. Presence of the virus was correlated with clinical and radiographic features of the cysts. Results: CMV was detected in 18 PCs (54.5%) and six OKCs (60%). The presence of CMV was more frequent in cyst samples collected from patients who reported previous episodes of acute infection. The presence of sinus tract was more frequent in CMV-positive cysts and CMV presence was less frequent in a group of cysts showing signs of acute inflammation at the time of sample collection. The mean sizes of CMV-positive and CMV-negative PCs were almost the same; CMV-positive OKCs were slightly larger than CMV-negative OKCs. None of these results proved to be statistically significant. Conclusion: The presence of CMV in the cystic wall is a common feature of both inflammatory and non-inflammatory odontogenic cysts. Although this study has not proved that CMV affects pathogenesis of odontogenic cysts, such a possibility could not be ruled out.
PB  - Blackwell Publishing, Oxford
T2  - Oral Microbiology & Immunology
T1  - Human cytomegalovirus is present in odontogenic cysts
VL  - 22
IS  - 5
SP  - 347
EP  - 351
DO  - 10.1111/j.1399-302X.2007.00369.x
ER  - 

@article{
author = "Andrić, Miroslav and Milašin, Jelena and Jovanović, T. and Todorović, L.",
year = "2007",
abstract = "Introduction: Recent studies suggest that some viruses, including human cytomegalovirus (CMV), may be involved in the pathogenesis of periapical lesions. Since periapical cysts (PCs) represent the next stage in the evolution of periapical granuloma, it seemed reasonable to investigate the presence of CMV in PCs and any possible relationship between its presence and the clinical features of those cysts, as well as to compare the results obtained with corresponding findings in non-inflammatory lesions, like odontogenic keratocysts (OKCs). Methods: Samples of 33 PCs and 10 OKCs, obtained at the time of surgery, were used for the detection of CMV DNA by polymerase chain reaction. Presence of the virus was correlated with clinical and radiographic features of the cysts. Results: CMV was detected in 18 PCs (54.5%) and six OKCs (60%). The presence of CMV was more frequent in cyst samples collected from patients who reported previous episodes of acute infection. The presence of sinus tract was more frequent in CMV-positive cysts and CMV presence was less frequent in a group of cysts showing signs of acute inflammation at the time of sample collection. The mean sizes of CMV-positive and CMV-negative PCs were almost the same; CMV-positive OKCs were slightly larger than CMV-negative OKCs. None of these results proved to be statistically significant. Conclusion: The presence of CMV in the cystic wall is a common feature of both inflammatory and non-inflammatory odontogenic cysts. Although this study has not proved that CMV affects pathogenesis of odontogenic cysts, such a possibility could not be ruled out.",
publisher = "Blackwell Publishing, Oxford",
journal = "Oral Microbiology & Immunology",
title = "Human cytomegalovirus is present in odontogenic cysts",
volume = "22",
number = "5",
pages = "347-351",
doi = "10.1111/j.1399-302X.2007.00369.x"
}

Andrić, M., Milašin, J., Jovanović, T.,& Todorović, L.. (2007). Human cytomegalovirus is present in odontogenic cysts. in Oral Microbiology & Immunology
Blackwell Publishing, Oxford., 22(5), 347-351.
https://doi.org/10.1111/j.1399-302X.2007.00369.x

Andrić M, Milašin J, Jovanović T, Todorović L. Human cytomegalovirus is present in odontogenic cysts. in Oral Microbiology & Immunology. 2007;22(5):347-351.
doi:10.1111/j.1399-302X.2007.00369.x .

Andrić, Miroslav, Milašin, Jelena, Jovanović, T., Todorović, L., "Human cytomegalovirus is present in odontogenic cysts" in Oral Microbiology & Immunology, 22, no. 5 (2007):347-351,
https://doi.org/10.1111/j.1399-302X.2007.00369.x . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Todorović, L.
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1304
AB  - Objectives: Postoperative pain is a common phenomenon after surgical extraction of lower third molars (LTM), and its successful control is an essential part of routine oral surgery. The aims of the study were twofold: (1) to evaluate the postoperative analgesic efficacy, comparing long-acting and intermediate-acting local anesthetics; and (2) to compare the use of low-power laser irradiation and the nonsteroid anti-inflammatory drug diclofenac, which are claimed to be among the most successful aids in postoperative pain control. Study design: A twofold study of 102 patients of both sexes undergoing surgical extraction of LTM was conducted. In the first part of the study, 12 patients with bilaterally impacted LTMs were treated in a double-blind crossover fashion; local anesthesia was achieved with 0.5% bupivacaine plain or 2% lidocaine with 1:80.000 epinephrine. In the second part of the study, 90 patients undergoing LTM surgical extraction with local anesthesia received postoperative low-power laser irradiation (30 patients) and a preoperative single dose of 100 mg diclofenac (30 patients), or only regular postoperative recommendations (30 patients). Results: The results of the first part of the study showed a strikingly better postoperative analgesic effect of bupivacaine than lidocaine/epinephrine (11 out of 12; 4 out of 12, respectively, patients without postoperative pain). In the second part of the study, low-power laser irradiation significantly reduced postoperative pain intensity in patients premedicated with diclofenac, compared with the controls. Conclusion: Provided that basic principles of surgical practice have been achieved, the use of long-acting local anesthetics and low-power laser irradiation enables the best postoperative analgesic effect and the most comfortable postoperative course after surgical extraction of LTMs.
PB  - Mosby Inc.
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
T1  - Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac
VL  - 102
IS  - 5
SP  - e4
EP  - e8
DO  - 10.1016/j.tripleo.2006.02.024
ER  - 

@article{
author = "Marković, Aleksa and Todorović, L.",
year = "2006",
abstract = "Objectives: Postoperative pain is a common phenomenon after surgical extraction of lower third molars (LTM), and its successful control is an essential part of routine oral surgery. The aims of the study were twofold: (1) to evaluate the postoperative analgesic efficacy, comparing long-acting and intermediate-acting local anesthetics; and (2) to compare the use of low-power laser irradiation and the nonsteroid anti-inflammatory drug diclofenac, which are claimed to be among the most successful aids in postoperative pain control. Study design: A twofold study of 102 patients of both sexes undergoing surgical extraction of LTM was conducted. In the first part of the study, 12 patients with bilaterally impacted LTMs were treated in a double-blind crossover fashion; local anesthesia was achieved with 0.5% bupivacaine plain or 2% lidocaine with 1:80.000 epinephrine. In the second part of the study, 90 patients undergoing LTM surgical extraction with local anesthesia received postoperative low-power laser irradiation (30 patients) and a preoperative single dose of 100 mg diclofenac (30 patients), or only regular postoperative recommendations (30 patients). Results: The results of the first part of the study showed a strikingly better postoperative analgesic effect of bupivacaine than lidocaine/epinephrine (11 out of 12; 4 out of 12, respectively, patients without postoperative pain). In the second part of the study, low-power laser irradiation significantly reduced postoperative pain intensity in patients premedicated with diclofenac, compared with the controls. Conclusion: Provided that basic principles of surgical practice have been achieved, the use of long-acting local anesthetics and low-power laser irradiation enables the best postoperative analgesic effect and the most comfortable postoperative course after surgical extraction of LTMs.",
publisher = "Mosby Inc.",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology",
title = "Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac",
volume = "102",
number = "5",
pages = "e4-e8",
doi = "10.1016/j.tripleo.2006.02.024"
}

Marković, A.,& Todorović, L.. (2006). Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology
Mosby Inc.., 102(5), e4-e8.
https://doi.org/10.1016/j.tripleo.2006.02.024

Marković A, Todorović L. Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology. 2006;102(5):e4-e8.
doi:10.1016/j.tripleo.2006.02.024 .

Marković, Aleksa, Todorović, L., "Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontology, 102, no. 5 (2006):e4-e8,
https://doi.org/10.1016/j.tripleo.2006.02.024 . .

TY  - JOUR
AU  - Brković, Božidar
AU  - Todorović, L
AU  - Stojić, D.
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1246
AB  - The admixture of clonidine or epinephrine to lidocaine for inferior alveolar nerve block was studied with regard to onset, duration, intensity of anaesthesia, postoperative analgesia, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), ST segment depression 1 mm and cardiac arrhythmias. Forty healthy patients (ASA I) received 2 ml 2% lidocaine with clonidine (15 mg/ml; n = 20) or epinephrine (12.5 mg/ml; n = 20) in a doubleblind fashion for lower third molar surgery. Duration and intensity were not different between groups, while onset was significantly different by subjective evaluation. The need for postoperative pain medication was significantly lower in the clonidine group. There was a significant decrease in SBP and MAP in both groups 35 min after administration of anaesthesia compared with basal values, while DBP was significantly lower only in the clonidine group. There was no significant difference in SBP, DBP and MAP between groups. HR was significantly increased in the epinephrine group 5 min after administration of anaesthesia and during surgery compared with the clonidine group and with basal values. The presented data suggest that clonidine could be a useful and safe alternative to epinephrine for intraoral block anaesthesia.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery
VL  - 34
IS  - 4
SP  - 401
EP  - 406
DO  - 10.1016/j.ijom.2004.06.014
ER  - 

@article{
author = "Brković, Božidar and Todorović, L and Stojić, D.",
year = "2005",
abstract = "The admixture of clonidine or epinephrine to lidocaine for inferior alveolar nerve block was studied with regard to onset, duration, intensity of anaesthesia, postoperative analgesia, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), ST segment depression 1 mm and cardiac arrhythmias. Forty healthy patients (ASA I) received 2 ml 2% lidocaine with clonidine (15 mg/ml; n = 20) or epinephrine (12.5 mg/ml; n = 20) in a doubleblind fashion for lower third molar surgery. Duration and intensity were not different between groups, while onset was significantly different by subjective evaluation. The need for postoperative pain medication was significantly lower in the clonidine group. There was a significant decrease in SBP and MAP in both groups 35 min after administration of anaesthesia compared with basal values, while DBP was significantly lower only in the clonidine group. There was no significant difference in SBP, DBP and MAP between groups. HR was significantly increased in the epinephrine group 5 min after administration of anaesthesia and during surgery compared with the clonidine group and with basal values. The presented data suggest that clonidine could be a useful and safe alternative to epinephrine for intraoral block anaesthesia.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery",
volume = "34",
number = "4",
pages = "401-406",
doi = "10.1016/j.ijom.2004.06.014"
}

Brković, B., Todorović, L.,& Stojić, D.. (2005). Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 34(4), 401-406.
https://doi.org/10.1016/j.ijom.2004.06.014

Brković B, Todorović L, Stojić D. Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery. in International Journal of Oral & Maxillofacial Surgery. 2005;34(4):401-406.
doi:10.1016/j.ijom.2004.06.014 .

Brković, Božidar, Todorović, L, Stojić, D., "Comparison of clonidine and epinephrine in lidocaine anaesthesia for lower third molar surgery" in International Journal of Oral & Maxillofacial Surgery, 34, no. 4 (2005):401-406,
https://doi.org/10.1016/j.ijom.2004.06.014 . .