TY  - JOUR
AU  - Petković, A. B.
AU  - Matić, S. M.
AU  - Stamatović, Novak
AU  - Vojvodić, Danilo
AU  - Todorović, T. M.
AU  - Lazić, Z. R.
AU  - Kozomara, Ružica
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1594
AB  - Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition
VL  - 39
IS  - 5
SP  - 478
EP  - 485
DO  - 10.1016/j.ijom.2010.01.014
ER  - 

@article{
author = "Petković, A. B. and Matić, S. M. and Stamatović, Novak and Vojvodić, Danilo and Todorović, T. M. and Lazić, Z. R. and Kozomara, Ružica",
year = "2010",
abstract = "Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition",
volume = "39",
number = "5",
pages = "478-485",
doi = "10.1016/j.ijom.2010.01.014"
}

Petković, A. B., Matić, S. M., Stamatović, N., Vojvodić, D., Todorović, T. M., Lazić, Z. R.,& Kozomara, R.. (2010). Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 39(5), 478-485.
https://doi.org/10.1016/j.ijom.2010.01.014

Petković AB, Matić SM, Stamatović N, Vojvodić D, Todorović TM, Lazić ZR, Kozomara R. Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition. in International Journal of Oral & Maxillofacial Surgery. 2010;39(5):478-485.
doi:10.1016/j.ijom.2010.01.014 .

Petković, A. B., Matić, S. M., Stamatović, Novak, Vojvodić, Danilo, Todorović, T. M., Lazić, Z. R., Kozomara, Ružica, "Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition" in International Journal of Oral & Maxillofacial Surgery, 39, no. 5 (2010):478-485,
https://doi.org/10.1016/j.ijom.2010.01.014 . .