TY  - JOUR
AU  - Marković-Vasiljković, Biljana
AU  - Antić, Svetlana
AU  - Jelovac, Drago
PY  - 2023
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3286
AB  - Background/Aim. The depth of invasion of oral cavity car cinoma (OCC) and the nodal involvement define the treat ment selection, outcome, and prognosis of the disease. In de termining the stage of OCC, the most widely applied methods 
are computerized tomography (CT) and magnetic resonance 
imaging (MRI), whose limitations can be overcome to some 
extent by using intraoral ultrasound (IOUS). The aim of the 
study was to evaluate the imaging presentation of early-stage 
OCC, determine the depth of invasion (DOI) and the greatest 
diameter (GD) of the tumor using the IOUS and CT meth ods, and compare them with histopathological (HP) findings. 
Methods. The study was designed as a prospective one, with 
a time limitation of three months. Eleven patients with clinical 
early-stage OCC underwent a native CT examination of the 
head and neck as well as a contrast-enhanced phase, and then 
IOUS of the lesion was performed. Using both methods, DOI 
and GD values were measured, and the values were correlated 
with HP findings. The analysis of the obtained data was per formed using the statistical package SPSS 22 and Pearson cor relation coefficient. Results. A significant correlation (p = 
0.001) was established between the DOI values measured by 
IOUS and CT examination with the measurements obtained 
by HP processing. On the other hand, by comparing the GD 
measured on IOUS and CT examination, no correlation was 
established with the HP report. Conclusion. Measurements 
of DOI obtained by IOUS significantly correlated with those 
in the HP report, while overcoming the limitations of the CT 
method in the evaluation of small-sized tumors and tumors 
that cannot be shown due to artifacts.
AB  - Uvod/Cilj. Dubina invazije karcinoma usne duplje i zah-vaćenost regionalnih limfnih čvorova definišu terapijski modalitet, ishod lečenja i prognozu bolesti. U određivanju stadijuma karcinoma usne duplje, najšire primenjivane metode su kompjuterizovana tomografija (KT) i magnetna rezonanca (MR), čija ograničenja se donekle mogu prevazići upotrebom intraoralnog ultrazvuka (IOUZ). Cilj rada bio je da se proceni vizuelni prikaz karcinoma usne duplje ranog stadijuma, odredi dubina invazije (DI) i najveći dijametar tumora (NDT) metodama IOUZ i KT, a zatim da se uporede sa histopatološkim (HP) nalazom. Metode. Studija je dizajnirana kao prospektivna sa vremenskim ograničen-jem od tri meseca. Kod 11 bolesnika sa ranim kliničkim sta-dijumom karcinoma usne duplje, urađen je nativni i postkontrastni pregled glave i vrata pomoću KT, a potom pregled lezije metodom IOUZ. Koristeći obe metode me-rene su vrednosti DI i NDT, koje su potom korelisane sa HP nalazom. Analiza dobijenih podataka izvršena je upo-trebom statističkog paketa SPSS 22 i Pearson-ovog koeficijenta korelacije. Rezultati. Ustanovljena je značajna korelacija (p = 0,001) između vrednosti DI izmerenih pomoću metoda IOUZ i KT, sa merama dobijenim HP ob-radom. Sa druge strane, upoređivanjem vrednosti za NDT izmerenih na IOUZ i KT pregledu, nije ustanovljena korel-acija sa HP izveštajem. Zaključak. Mere DI dobijene metodom IOUZ značajno su korelisale sa onim u HP izveštaju, uz prevazilaženje ograničenja KT metode u evaluaciji tumora malih dimenzija i tumora koji se zbog artefakata ne mogu prikazati.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Comparative assessment of the depth of invasion of early-stage oral cavity carcinomas based on intraoral ultrasound and computerized tomography findings
T1  - Komparativna procena dubine invazije tumora usne duplje u ranom stadijumu na osnovu nalaza intraoralnog ultrazvuka i kompjuterizovane tomografije
VL  - 80
IS  - 11
SP  - 921
EP  - 926
DO  - 10.2298/VSP221202048M
ER  - 

@article{
author = "Marković-Vasiljković, Biljana and Antić, Svetlana and Jelovac, Drago",
year = "2023",
abstract = "Background/Aim. The depth of invasion of oral cavity car cinoma (OCC) and the nodal involvement define the treat ment selection, outcome, and prognosis of the disease. In de termining the stage of OCC, the most widely applied methods 
are computerized tomography (CT) and magnetic resonance 
imaging (MRI), whose limitations can be overcome to some 
extent by using intraoral ultrasound (IOUS). The aim of the 
study was to evaluate the imaging presentation of early-stage 
OCC, determine the depth of invasion (DOI) and the greatest 
diameter (GD) of the tumor using the IOUS and CT meth ods, and compare them with histopathological (HP) findings. 
Methods. The study was designed as a prospective one, with 
a time limitation of three months. Eleven patients with clinical 
early-stage OCC underwent a native CT examination of the 
head and neck as well as a contrast-enhanced phase, and then 
IOUS of the lesion was performed. Using both methods, DOI 
and GD values were measured, and the values were correlated 
with HP findings. The analysis of the obtained data was per formed using the statistical package SPSS 22 and Pearson cor relation coefficient. Results. A significant correlation (p = 
0.001) was established between the DOI values measured by 
IOUS and CT examination with the measurements obtained 
by HP processing. On the other hand, by comparing the GD 
measured on IOUS and CT examination, no correlation was 
established with the HP report. Conclusion. Measurements 
of DOI obtained by IOUS significantly correlated with those 
in the HP report, while overcoming the limitations of the CT 
method in the evaluation of small-sized tumors and tumors 
that cannot be shown due to artifacts., Uvod/Cilj. Dubina invazije karcinoma usne duplje i zah-vaćenost regionalnih limfnih čvorova definišu terapijski modalitet, ishod lečenja i prognozu bolesti. U određivanju stadijuma karcinoma usne duplje, najšire primenjivane metode su kompjuterizovana tomografija (KT) i magnetna rezonanca (MR), čija ograničenja se donekle mogu prevazići upotrebom intraoralnog ultrazvuka (IOUZ). Cilj rada bio je da se proceni vizuelni prikaz karcinoma usne duplje ranog stadijuma, odredi dubina invazije (DI) i najveći dijametar tumora (NDT) metodama IOUZ i KT, a zatim da se uporede sa histopatološkim (HP) nalazom. Metode. Studija je dizajnirana kao prospektivna sa vremenskim ograničen-jem od tri meseca. Kod 11 bolesnika sa ranim kliničkim sta-dijumom karcinoma usne duplje, urađen je nativni i postkontrastni pregled glave i vrata pomoću KT, a potom pregled lezije metodom IOUZ. Koristeći obe metode me-rene su vrednosti DI i NDT, koje su potom korelisane sa HP nalazom. Analiza dobijenih podataka izvršena je upo-trebom statističkog paketa SPSS 22 i Pearson-ovog koeficijenta korelacije. Rezultati. Ustanovljena je značajna korelacija (p = 0,001) između vrednosti DI izmerenih pomoću metoda IOUZ i KT, sa merama dobijenim HP ob-radom. Sa druge strane, upoređivanjem vrednosti za NDT izmerenih na IOUZ i KT pregledu, nije ustanovljena korel-acija sa HP izveštajem. Zaključak. Mere DI dobijene metodom IOUZ značajno su korelisale sa onim u HP izveštaju, uz prevazilaženje ograničenja KT metode u evaluaciji tumora malih dimenzija i tumora koji se zbog artefakata ne mogu prikazati.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Comparative assessment of the depth of invasion of early-stage oral cavity carcinomas based on intraoral ultrasound and computerized tomography findings, Komparativna procena dubine invazije tumora usne duplje u ranom stadijumu na osnovu nalaza intraoralnog ultrazvuka i kompjuterizovane tomografije",
volume = "80",
number = "11",
pages = "921-926",
doi = "10.2298/VSP221202048M"
}

Marković-Vasiljković, B., Antić, S.,& Jelovac, D.. (2023). Comparative assessment of the depth of invasion of early-stage oral cavity carcinomas based on intraoral ultrasound and computerized tomography findings. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 80(11), 921-926.
https://doi.org/10.2298/VSP221202048M

Marković-Vasiljković B, Antić S, Jelovac D. Comparative assessment of the depth of invasion of early-stage oral cavity carcinomas based on intraoral ultrasound and computerized tomography findings. in Vojnosanitetski pregled. 2023;80(11):921-926.
doi:10.2298/VSP221202048M .

Marković-Vasiljković, Biljana, Antić, Svetlana, Jelovac, Drago, "Comparative assessment of the depth of invasion of early-stage oral cavity carcinomas based on intraoral ultrasound and computerized tomography findings" in Vojnosanitetski pregled, 80, no. 11 (2023):921-926,
https://doi.org/10.2298/VSP221202048M . .

TY  - JOUR
AU  - Antić, Svetlana
AU  - Marković-Vasiljković, Biljana
AU  - Dželetović, Bojan
AU  - Jelovac, Drago
AU  - Kuzmanović-Pfićer, Jovana
PY  - 2022
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3290
AB  - Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended.
PB  - Faculdade de Odontologia de Bauru da Universidade de Sao Paulo
T2  - Journal of Applied Oral Science
T1  - Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study
VL  - 30
SP  - e20220329
DO  - 10.1590/1678-7757-2022-0329
ER  - 

@article{
author = "Antić, Svetlana and Marković-Vasiljković, Biljana and Dželetović, Bojan and Jelovac, Drago and Kuzmanović-Pfićer, Jovana",
year = "2022",
abstract = "Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended.",
publisher = "Faculdade de Odontologia de Bauru da Universidade de Sao Paulo",
journal = "Journal of Applied Oral Science",
title = "Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study",
volume = "30",
pages = "e20220329",
doi = "10.1590/1678-7757-2022-0329"
}

Antić, S., Marković-Vasiljković, B., Dželetović, B., Jelovac, D.,& Kuzmanović-Pfićer, J.. (2022). Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study. in Journal of Applied Oral Science
Faculdade de Odontologia de Bauru da Universidade de Sao Paulo., 30, e20220329.
https://doi.org/10.1590/1678-7757-2022-0329

Antić S, Marković-Vasiljković B, Dželetović B, Jelovac D, Kuzmanović-Pfićer J. Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study. in Journal of Applied Oral Science. 2022;30:e20220329.
doi:10.1590/1678-7757-2022-0329 .

Antić, Svetlana, Marković-Vasiljković, Biljana, Dželetović, Bojan, Jelovac, Drago, Kuzmanović-Pfićer, Jovana, "Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study" in Journal of Applied Oral Science, 30 (2022):e20220329,
https://doi.org/10.1590/1678-7757-2022-0329 . .

TY  - JOUR
AU  - Milošević-Marković, Maja
AU  - Lazarević, Miloš
AU  - Toljić, Boško
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Jelovac, Drago
AU  - Jovanović, Svetlana
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3283
AB  - Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.
PB  - TECH SCIENCE PRESS
T2  - BIOCELL
T1  - Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential
VL  - 45
IS  - 6
SP  - 1543
EP  - 1550
DO  - 10.32604/biocell.2021.015060
ER  - 

@article{
author = "Milošević-Marković, Maja and Lazarević, Miloš and Toljić, Boško and Petrović, Milan and Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Jelovac, Drago and Jovanović, Svetlana and Milašin, Jelena",
year = "2021",
abstract = "Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.",
publisher = "TECH SCIENCE PRESS",
journal = "BIOCELL",
title = "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential",
volume = "45",
number = "6",
pages = "1543-1550",
doi = "10.32604/biocell.2021.015060"
}

Milošević-Marković, M., Lazarević, M., Toljić, B., Petrović, M., Vukadinović, M., Jezdić, Z., Aničić, B., Jelovac, D., Jovanović, S.,& Milašin, J.. (2021). Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL
TECH SCIENCE PRESS., 45(6), 1543-1550.
https://doi.org/10.32604/biocell.2021.015060

Milošević-Marković M, Lazarević M, Toljić B, Petrović M, Vukadinović M, Jezdić Z, Aničić B, Jelovac D, Jovanović S, Milašin J. Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL. 2021;45(6):1543-1550.
doi:10.32604/biocell.2021.015060 .

Milošević-Marković, Maja, Lazarević, Miloš, Toljić, Boško, Petrović, Milan, Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Jelovac, Drago, Jovanović, Svetlana, Milašin, Jelena, "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential" in BIOCELL, 45, no. 6 (2021):1543-1550,
https://doi.org/10.32604/biocell.2021.015060 . .

TY  - JOUR
AU  - Čarkić, Jelena
AU  - Nikolić, Nadja
AU  - Nišević, Jelena
AU  - Lazarević, Miloš
AU  - Kuzmanović-Pfićer, Jovana
AU  - Jelovac, Drago
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2567
AB  - Oral carcinoma is the sixth most common malignancy worldwide, with survival rates of approximately 50%. The major type of oral cancer, present in 90% of the cases, is oral squamous cell carcinoma (OSCC). The genetic background predisposing an individual to OSCC is complex and largely unknown. Studies have suggested that endothelial nitric oxide synthase (eNOS) gene polymorphisms modulate the cancer risk, prompting us to assess the impact of three functional eNOS gene polymorphisms on OSCC risk. The present study included 50 patients with OSCC and 110 controls. Polymerase chain reaction and restriction fragment length polymorphism analysis were used for genotyping of single-nucleotide polymorphisms -786 T/C (rs2070744) and 894 G/T (rs1799983) and variable number of tandem repeats (VNTR) intron 4b/a polymorphism. Homozygous carriers of -786 T/C and intron 4b/a VNTR variant alleles paired with a significant increase of oral cancer risk [odds ratio (OR): 3.63, 95% confidence interval (CI): 1.08-12.21; P = 0.045 and OR: 11.29, 95% CI: 2.71-47.11; P < 0.001, respectively]. When combined, CC and 4b4a genotypes together led to a 21-fold OSCC risk increase (OR: 21, 95% CI: 2.07-213.29; P = 0.006). Haplotype analysis showed that the C-G-4b haplotype conferred an 11-fold increase in OSCC risk. In conclusion, eNOS polymorphisms considerably influence levels of OSCC risk in the Serbian population.
PB  - Nihon University, School of Dentistry, Japan
T2  - Journal of Oral Science
T1  - Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in Serbian population
VL  - 62
IS  - 3
SP  - 322
EP  - 326
DO  - 10.2334/josnusd.19-0310
ER  - 

@article{
author = "Čarkić, Jelena and Nikolić, Nadja and Nišević, Jelena and Lazarević, Miloš and Kuzmanović-Pfićer, Jovana and Jelovac, Drago and Milašin, Jelena",
year = "2020",
abstract = "Oral carcinoma is the sixth most common malignancy worldwide, with survival rates of approximately 50%. The major type of oral cancer, present in 90% of the cases, is oral squamous cell carcinoma (OSCC). The genetic background predisposing an individual to OSCC is complex and largely unknown. Studies have suggested that endothelial nitric oxide synthase (eNOS) gene polymorphisms modulate the cancer risk, prompting us to assess the impact of three functional eNOS gene polymorphisms on OSCC risk. The present study included 50 patients with OSCC and 110 controls. Polymerase chain reaction and restriction fragment length polymorphism analysis were used for genotyping of single-nucleotide polymorphisms -786 T/C (rs2070744) and 894 G/T (rs1799983) and variable number of tandem repeats (VNTR) intron 4b/a polymorphism. Homozygous carriers of -786 T/C and intron 4b/a VNTR variant alleles paired with a significant increase of oral cancer risk [odds ratio (OR): 3.63, 95% confidence interval (CI): 1.08-12.21; P = 0.045 and OR: 11.29, 95% CI: 2.71-47.11; P < 0.001, respectively]. When combined, CC and 4b4a genotypes together led to a 21-fold OSCC risk increase (OR: 21, 95% CI: 2.07-213.29; P = 0.006). Haplotype analysis showed that the C-G-4b haplotype conferred an 11-fold increase in OSCC risk. In conclusion, eNOS polymorphisms considerably influence levels of OSCC risk in the Serbian population.",
publisher = "Nihon University, School of Dentistry, Japan",
journal = "Journal of Oral Science",
title = "Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in Serbian population",
volume = "62",
number = "3",
pages = "322-326",
doi = "10.2334/josnusd.19-0310"
}

Čarkić, J., Nikolić, N., Nišević, J., Lazarević, M., Kuzmanović-Pfićer, J., Jelovac, D.,& Milašin, J.. (2020). Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in Serbian population. in Journal of Oral Science
Nihon University, School of Dentistry, Japan., 62(3), 322-326.
https://doi.org/10.2334/josnusd.19-0310

Čarkić J, Nikolić N, Nišević J, Lazarević M, Kuzmanović-Pfićer J, Jelovac D, Milašin J. Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in Serbian population. in Journal of Oral Science. 2020;62(3):322-326.
doi:10.2334/josnusd.19-0310 .

Čarkić, Jelena, Nikolić, Nadja, Nišević, Jelena, Lazarević, Miloš, Kuzmanović-Pfićer, Jovana, Jelovac, Drago, Milašin, Jelena, "Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in Serbian population" in Journal of Oral Science, 62, no. 3 (2020):322-326,
https://doi.org/10.2334/josnusd.19-0310 . .

TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Jelovac, Drago
AU  - Milenković, Sanja
AU  - Tepavčević, Zvezdana
AU  - Baldan, Federica
AU  - Suboticki, Tijana
AU  - Toljić, Boško
AU  - Trišić, Dijana
AU  - Dragović, Miroslav
AU  - Damante, Giuseppe
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2484
AB  - Epithelial to mesenchymal transition (EMT) is a feature of several types of human cancer, including oral squamous cell carcinoma (OSCC). In the present study, tumor and margin cell cultures obtained from patients with OSCC were used to determine the expression patterns of certain EMT-associated markers, including vimentin, alpha -smooth muscle actin, SLUG and SNAIL. In addition, other EMT-associated features, including clonal, proliferative and migratory potential were compared between the two cell types. Cell cultures were generated from tumor and margin tissue samples from 6 patients and cultured up to the fifth passage. EMT marker expression was assessed by reverse transcription-quantitative PCR. Cell proliferation, colony formation and scratch wound healing assays were conducted to characterize the two cell types in terms of proliferation rates, clonality and motility. All of the studied markers were expressed in tumor and margin cells. Although no significant differences were noted with regard to the aforementioned markers, their expression tended to be higher in margin cultures than in tumor cultures. The expressions of the EMT markers were also higher in the fifth passage compared with those noted at the first with a few exceptions. The rates of proliferation and cell migration were decreased during passages, while the number of colonies was increased in both types of cell culture. Tumor and margin cells indicated certain similarities with regard to EMT transition characteristics.
PB  - SPANDIDOS PUBL LTD, ATHENS
T2  - Oncology Letters
T1  - Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study
VL  - 19
IS  - 6
SP  - 3743
EP  - 3750
DO  - 10.3892/ol.2020.11494
ER  - 

@article{
author = "Lazarević, Miloš and Milošević, Maja and Jelovac, Drago and Milenković, Sanja and Tepavčević, Zvezdana and Baldan, Federica and Suboticki, Tijana and Toljić, Boško and Trišić, Dijana and Dragović, Miroslav and Damante, Giuseppe and Milašin, Jelena",
year = "2020",
abstract = "Epithelial to mesenchymal transition (EMT) is a feature of several types of human cancer, including oral squamous cell carcinoma (OSCC). In the present study, tumor and margin cell cultures obtained from patients with OSCC were used to determine the expression patterns of certain EMT-associated markers, including vimentin, alpha -smooth muscle actin, SLUG and SNAIL. In addition, other EMT-associated features, including clonal, proliferative and migratory potential were compared between the two cell types. Cell cultures were generated from tumor and margin tissue samples from 6 patients and cultured up to the fifth passage. EMT marker expression was assessed by reverse transcription-quantitative PCR. Cell proliferation, colony formation and scratch wound healing assays were conducted to characterize the two cell types in terms of proliferation rates, clonality and motility. All of the studied markers were expressed in tumor and margin cells. Although no significant differences were noted with regard to the aforementioned markers, their expression tended to be higher in margin cultures than in tumor cultures. The expressions of the EMT markers were also higher in the fifth passage compared with those noted at the first with a few exceptions. The rates of proliferation and cell migration were decreased during passages, while the number of colonies was increased in both types of cell culture. Tumor and margin cells indicated certain similarities with regard to EMT transition characteristics.",
publisher = "SPANDIDOS PUBL LTD, ATHENS",
journal = "Oncology Letters",
title = "Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study",
volume = "19",
number = "6",
pages = "3743-3750",
doi = "10.3892/ol.2020.11494"
}

Lazarević, M., Milošević, M., Jelovac, D., Milenković, S., Tepavčević, Z., Baldan, F., Suboticki, T., Toljić, B., Trišić, D., Dragović, M., Damante, G.,& Milašin, J.. (2020). Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study. in Oncology Letters
SPANDIDOS PUBL LTD, ATHENS., 19(6), 3743-3750.
https://doi.org/10.3892/ol.2020.11494

Lazarević M, Milošević M, Jelovac D, Milenković S, Tepavčević Z, Baldan F, Suboticki T, Toljić B, Trišić D, Dragović M, Damante G, Milašin J. Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study. in Oncology Letters. 2020;19(6):3743-3750.
doi:10.3892/ol.2020.11494 .

Lazarević, Miloš, Milošević, Maja, Jelovac, Drago, Milenković, Sanja, Tepavčević, Zvezdana, Baldan, Federica, Suboticki, Tijana, Toljić, Boško, Trišić, Dijana, Dragović, Miroslav, Damante, Giuseppe, Milašin, Jelena, "Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study" in Oncology Letters, 19, no. 6 (2020):3743-3750,
https://doi.org/10.3892/ol.2020.11494 . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Jelovac, Drago
AU  - Antić, Svetlana
AU  - Antunović, Marija
AU  - Lukić, Nikola
AU  - Sabani, Melvil
AU  - Mudrak, Joerg
AU  - Jezdić, Zoran
AU  - Pucar, Ana
AU  - Stefanović, Aleksandar
AU  - Kuzmanović, Čedomir
AU  - Nikolić, Danilo
AU  - Konstantinović, Vitomir
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2443
AB  - This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies
VL  - 2019
DO  - 10.1155/2019/8345309
ER  - 

@article{
author = "Petrović, Milan and Jelovac, Drago and Antić, Svetlana and Antunović, Marija and Lukić, Nikola and Sabani, Melvil and Mudrak, Joerg and Jezdić, Zoran and Pucar, Ana and Stefanović, Aleksandar and Kuzmanović, Čedomir and Nikolić, Danilo and Konstantinović, Vitomir",
year = "2019",
abstract = "This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies",
volume = "2019",
doi = "10.1155/2019/8345309"
}

Petrović, M., Jelovac, D., Antić, S., Antunović, M., Lukić, N., Sabani, M., Mudrak, J., Jezdić, Z., Pucar, A., Stefanović, A., Kuzmanović, Č., Nikolić, D.,& Konstantinović, V.. (2019). Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International
Hindawi Ltd, London., 2019.
https://doi.org/10.1155/2019/8345309

Petrović M, Jelovac D, Antić S, Antunović M, Lukić N, Sabani M, Mudrak J, Jezdić Z, Pucar A, Stefanović A, Kuzmanović Č, Nikolić D, Konstantinović V. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International. 2019;2019.
doi:10.1155/2019/8345309 .

Petrović, Milan, Jelovac, Drago, Antić, Svetlana, Antunović, Marija, Lukić, Nikola, Sabani, Melvil, Mudrak, Joerg, Jezdić, Zoran, Pucar, Ana, Stefanović, Aleksandar, Kuzmanović, Čedomir, Nikolić, Danilo, Konstantinović, Vitomir, "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies" in Biomed Research International, 2019 (2019),
https://doi.org/10.1155/2019/8345309 . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Pezzana, Andrea
AU  - Benech, Arnaldo
AU  - Corre, Pierre
AU  - Bertin, Helios
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Petrov, Petko
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Romanova, Anna
AU  - Shuminsky, Eugen
AU  - Dediol, Emil
AU  - Tarle, Marko
AU  - Konstantinović, Vitomir
AU  - Jelovac, Drago
AU  - Karagozoglu, Hakki K.
AU  - Forouzanfar, Tymour
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2451
AB  - Purpose: The aim of this study was to analyze the demographic variables and causes and characteristics of mandibular angle fractures managed at several European departments of maxillofacial surgery. Materials and Methods: This study was based on a multicenter systematic database that allowed the recording of data from all patients with mandibular angle fractures between January 1, 2013, and December 31, 2017. The following data were recorded: gender, age, etiology, side of angle fracture, associated mandibular fractures, presence of third molar, intermaxillary fixation, and osteosynthesis. Results: The study included 1,162 patients (1,045 male and 117 female patients). A significant association was found between the presence of a third molar and the diagnosis of an isolated angle fracture (P  lt  .0000005). Furthermore, assaults were associated with the presence of voluptuary habits (P  lt  .00005), a younger mean age (P  lt  .00000005), male gender (P  lt  .00000005), and left- sided angle fractures (P  lt  .00000005). Conclusions: Assaults and falls actually represent the most frequent causes of angle fractures. The presence of a third molar may let the force completely disperse during the determination of the angle fracture, finding a point of weakness.
PB  - W B Saunders Co-Elsevier Inc, Philadelphia
T2  - Journal of Oral & Maxillofacial Surgery
T1  - The 'European Mandibular Angle'' Research Project: The Epidemiologic Results From a Multicenter European Collaboration
VL  - 77
IS  - 4
DO  - 10.1016/j.joms.2018.12.013
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Pezzana, Andrea and Benech, Arnaldo and Corre, Pierre and Bertin, Helios and Pechalova, Petia and Pavlov, Nikolai and Petrov, Petko and Tamme, Tiia and Kopchak, Andrey and Romanova, Anna and Shuminsky, Eugen and Dediol, Emil and Tarle, Marko and Konstantinović, Vitomir and Jelovac, Drago and Karagozoglu, Hakki K. and Forouzanfar, Tymour",
year = "2019",
abstract = "Purpose: The aim of this study was to analyze the demographic variables and causes and characteristics of mandibular angle fractures managed at several European departments of maxillofacial surgery. Materials and Methods: This study was based on a multicenter systematic database that allowed the recording of data from all patients with mandibular angle fractures between January 1, 2013, and December 31, 2017. The following data were recorded: gender, age, etiology, side of angle fracture, associated mandibular fractures, presence of third molar, intermaxillary fixation, and osteosynthesis. Results: The study included 1,162 patients (1,045 male and 117 female patients). A significant association was found between the presence of a third molar and the diagnosis of an isolated angle fracture (P  lt  .0000005). Furthermore, assaults were associated with the presence of voluptuary habits (P  lt  .00005), a younger mean age (P  lt  .00000005), male gender (P  lt  .00000005), and left- sided angle fractures (P  lt  .00000005). Conclusions: Assaults and falls actually represent the most frequent causes of angle fractures. The presence of a third molar may let the force completely disperse during the determination of the angle fracture, finding a point of weakness.",
publisher = "W B Saunders Co-Elsevier Inc, Philadelphia",
journal = "Journal of Oral & Maxillofacial Surgery",
title = "The 'European Mandibular Angle'' Research Project: The Epidemiologic Results From a Multicenter European Collaboration",
volume = "77",
number = "4",
doi = "10.1016/j.joms.2018.12.013"
}

Brucoli, M., Boffano, P., Pezzana, A., Benech, A., Corre, P., Bertin, H., Pechalova, P., Pavlov, N., Petrov, P., Tamme, T., Kopchak, A., Romanova, A., Shuminsky, E., Dediol, E., Tarle, M., Konstantinović, V., Jelovac, D., Karagozoglu, H. K.,& Forouzanfar, T.. (2019). The 'European Mandibular Angle'' Research Project: The Epidemiologic Results From a Multicenter European Collaboration. in Journal of Oral & Maxillofacial Surgery
W B Saunders Co-Elsevier Inc, Philadelphia., 77(4).
https://doi.org/10.1016/j.joms.2018.12.013

Brucoli M, Boffano P, Pezzana A, Benech A, Corre P, Bertin H, Pechalova P, Pavlov N, Petrov P, Tamme T, Kopchak A, Romanova A, Shuminsky E, Dediol E, Tarle M, Konstantinović V, Jelovac D, Karagozoglu HK, Forouzanfar T. The 'European Mandibular Angle'' Research Project: The Epidemiologic Results From a Multicenter European Collaboration. in Journal of Oral & Maxillofacial Surgery. 2019;77(4).
doi:10.1016/j.joms.2018.12.013 .

Brucoli, Matteo, Boffano, Paolo, Pezzana, Andrea, Benech, Arnaldo, Corre, Pierre, Bertin, Helios, Pechalova, Petia, Pavlov, Nikolai, Petrov, Petko, Tamme, Tiia, Kopchak, Andrey, Romanova, Anna, Shuminsky, Eugen, Dediol, Emil, Tarle, Marko, Konstantinović, Vitomir, Jelovac, Drago, Karagozoglu, Hakki K., Forouzanfar, Tymour, "The 'European Mandibular Angle'' Research Project: The Epidemiologic Results From a Multicenter European Collaboration" in Journal of Oral & Maxillofacial Surgery, 77, no. 4 (2019),
https://doi.org/10.1016/j.joms.2018.12.013 . .

TY  - JOUR
AU  - Lisul, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Tepavčević, Zvezdana
AU  - Koruga, Đuro
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2424
AB  - PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical & Biological Engineering
T1  - Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins
VL  - 39
IS  - 6
SP  - 874
EP  - 884
DO  - 10.1007/s40846-019-00473-y
ER  - 

@article{
author = "Lisul, Bogdan and Jelovac, Drago and Petrović, Milan and Tepavčević, Zvezdana and Koruga, Đuro and Grga, Đurica",
year = "2019",
abstract = "PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical & Biological Engineering",
title = "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins",
volume = "39",
number = "6",
pages = "874-884",
doi = "10.1007/s40846-019-00473-y"
}

Lisul, B., Jelovac, D., Petrović, M., Tepavčević, Z., Koruga, Đ.,& Grga, Đ.. (2019). Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering
Springer Heidelberg, Heidelberg., 39(6), 874-884.
https://doi.org/10.1007/s40846-019-00473-y

Lisul B, Jelovac D, Petrović M, Tepavčević Z, Koruga Đ, Grga Đ. Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering. 2019;39(6):874-884.
doi:10.1007/s40846-019-00473-y .

Lisul, Bogdan, Jelovac, Drago, Petrović, Milan, Tepavčević, Zvezdana, Koruga, Đuro, Grga, Đurica, "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins" in Journal of Medical & Biological Engineering, 39, no. 6 (2019):874-884,
https://doi.org/10.1007/s40846-019-00473-y . .

TY  - JOUR
AU  - Brucoli, Matteo
AU  - Boffano, Paolo
AU  - Pezzana, Andrea
AU  - Benech, Arnaldo
AU  - Cone, Pierre
AU  - Bertin, Helios
AU  - Pechalova, Petia
AU  - Pavlov, Nikolai
AU  - Petrov, Petko
AU  - Tamme, Tiia
AU  - Kopchak, Andrey
AU  - Romanova, Anna
AU  - Shuminsky, Eugen
AU  - Dediol, Emil
AU  - Tarle, Marko
AU  - Konstantinović, Vitomir
AU  - Jelovac, Drago
AU  - Karagozoglu, Hakki K.
AU  - Forouzanfar, Tymour
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2398
AB  - Objective. The aim of this study was to analyze the complications and outcomes of surgical treatment of angle fractures managed at departments of maxillofacial surgery in several European countries. Study Design. Patients hospitalized with unilateral isolated angle fractures between 2013 and 2017 were included. The following data were recorded: gender and age of patients, fracture etiology, presence of the third molar, maxillomandibular fixation, osteosynthesis technique, and complications. Results. In total, 489 patients were included in the study. The Champy technique was found to be the most frequently chosen osteosynthesis technique. Sixty complications were observed, at a rate of 12.3%. Complications were associated with the absence of third molars (P  lt  .05). Instead, the Champy technique was associated with fewer complications (P  lt  .05), in comparison with the other adopted techniques. Conclusions. The management of angle fractures still represents a challenging task with a significant complication rate. The Champy technique still seems to be a valid option for the treatment of such injuries.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - The 'European Mandibular Angle' research project: the analysis of complications after unilateral Angle fractures
VL  - 128
IS  - 1
SP  - 14
EP  - 17
DO  - 10.1016/j.oooo.2019.02.027
ER  - 

@article{
author = "Brucoli, Matteo and Boffano, Paolo and Pezzana, Andrea and Benech, Arnaldo and Cone, Pierre and Bertin, Helios and Pechalova, Petia and Pavlov, Nikolai and Petrov, Petko and Tamme, Tiia and Kopchak, Andrey and Romanova, Anna and Shuminsky, Eugen and Dediol, Emil and Tarle, Marko and Konstantinović, Vitomir and Jelovac, Drago and Karagozoglu, Hakki K. and Forouzanfar, Tymour",
year = "2019",
abstract = "Objective. The aim of this study was to analyze the complications and outcomes of surgical treatment of angle fractures managed at departments of maxillofacial surgery in several European countries. Study Design. Patients hospitalized with unilateral isolated angle fractures between 2013 and 2017 were included. The following data were recorded: gender and age of patients, fracture etiology, presence of the third molar, maxillomandibular fixation, osteosynthesis technique, and complications. Results. In total, 489 patients were included in the study. The Champy technique was found to be the most frequently chosen osteosynthesis technique. Sixty complications were observed, at a rate of 12.3%. Complications were associated with the absence of third molars (P  lt  .05). Instead, the Champy technique was associated with fewer complications (P  lt  .05), in comparison with the other adopted techniques. Conclusions. The management of angle fractures still represents a challenging task with a significant complication rate. The Champy technique still seems to be a valid option for the treatment of such injuries.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "The 'European Mandibular Angle' research project: the analysis of complications after unilateral Angle fractures",
volume = "128",
number = "1",
pages = "14-17",
doi = "10.1016/j.oooo.2019.02.027"
}

Brucoli, M., Boffano, P., Pezzana, A., Benech, A., Cone, P., Bertin, H., Pechalova, P., Pavlov, N., Petrov, P., Tamme, T., Kopchak, A., Romanova, A., Shuminsky, E., Dediol, E., Tarle, M., Konstantinović, V., Jelovac, D., Karagozoglu, H. K.,& Forouzanfar, T.. (2019). The 'European Mandibular Angle' research project: the analysis of complications after unilateral Angle fractures. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 128(1), 14-17.
https://doi.org/10.1016/j.oooo.2019.02.027

Brucoli M, Boffano P, Pezzana A, Benech A, Cone P, Bertin H, Pechalova P, Pavlov N, Petrov P, Tamme T, Kopchak A, Romanova A, Shuminsky E, Dediol E, Tarle M, Konstantinović V, Jelovac D, Karagozoglu HK, Forouzanfar T. The 'European Mandibular Angle' research project: the analysis of complications after unilateral Angle fractures. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2019;128(1):14-17.
doi:10.1016/j.oooo.2019.02.027 .

Brucoli, Matteo, Boffano, Paolo, Pezzana, Andrea, Benech, Arnaldo, Cone, Pierre, Bertin, Helios, Pechalova, Petia, Pavlov, Nikolai, Petrov, Petko, Tamme, Tiia, Kopchak, Andrey, Romanova, Anna, Shuminsky, Eugen, Dediol, Emil, Tarle, Marko, Konstantinović, Vitomir, Jelovac, Drago, Karagozoglu, Hakki K., Forouzanfar, Tymour, "The 'European Mandibular Angle' research project: the analysis of complications after unilateral Angle fractures" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 128, no. 1 (2019):14-17,
https://doi.org/10.1016/j.oooo.2019.02.027 . .

TY  - JOUR
AU  - Eljabo, Najib
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Jelovac, Drago
AU  - Lazarević, M.
AU  - Tanić, Nasta
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2301
AB  - Despite adequate surgical resection, oral squamous cell carcinoma (OSCC) shows a high rate of recurrence and metastasis, which could be explained by the presence of molecular alterations in seemingly normal tumour margins and the entire oral mucosa. The aims of this study were (1) to assess the presence of gene amplification (c-Myc and HER2) and promoter methylation (p14 and p16) in the tumours, tumour margins, and unaffected oral mucosa of 40 OSCC patients, and (2) to evaluate the possibility of using these alterations as prognostic markers. c-Myc and HER2 genes were quantified by means of real-time PCR (qPCR), and p14 and p16 methylation status was determined by methylation-specific PCR (MSP PCR). All tissues examined exhibited molecular alterations in various proportions. Tumour tissues, as expected, showed the highest prevalence of alterations, while oral mucosa showed the lowest. Multiple alterations (co-alterations) in tumours and tumour margins were significantly more frequent than in unaffected oral mucosa (P  lt  0.001 and P = 0.027, respectively). HER2 amplification in margin tissue (P  lt  0.001) and swabs (P = 0.013), as well as the existence of three co-alterations in margins (P = 0.001) and macroscopically unaffected oral mucosa (P  lt  0.001) were correlated with shorter disease-specific survival.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Genetic and epigenetic alterations in the tumour, tumour margins, and normal buccal mucosa of patients with oral cancer
VL  - 47
IS  - 8
SP  - 976
EP  - 982
DO  - 10.1016/j.ijom.2018.01.020
ER  - 

@article{
author = "Eljabo, Najib and Nikolić, Nadja and Čarkić, Jelena and Jelovac, Drago and Lazarević, M. and Tanić, Nasta and Milašin, Jelena",
year = "2018",
abstract = "Despite adequate surgical resection, oral squamous cell carcinoma (OSCC) shows a high rate of recurrence and metastasis, which could be explained by the presence of molecular alterations in seemingly normal tumour margins and the entire oral mucosa. The aims of this study were (1) to assess the presence of gene amplification (c-Myc and HER2) and promoter methylation (p14 and p16) in the tumours, tumour margins, and unaffected oral mucosa of 40 OSCC patients, and (2) to evaluate the possibility of using these alterations as prognostic markers. c-Myc and HER2 genes were quantified by means of real-time PCR (qPCR), and p14 and p16 methylation status was determined by methylation-specific PCR (MSP PCR). All tissues examined exhibited molecular alterations in various proportions. Tumour tissues, as expected, showed the highest prevalence of alterations, while oral mucosa showed the lowest. Multiple alterations (co-alterations) in tumours and tumour margins were significantly more frequent than in unaffected oral mucosa (P  lt  0.001 and P = 0.027, respectively). HER2 amplification in margin tissue (P  lt  0.001) and swabs (P = 0.013), as well as the existence of three co-alterations in margins (P = 0.001) and macroscopically unaffected oral mucosa (P  lt  0.001) were correlated with shorter disease-specific survival.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Genetic and epigenetic alterations in the tumour, tumour margins, and normal buccal mucosa of patients with oral cancer",
volume = "47",
number = "8",
pages = "976-982",
doi = "10.1016/j.ijom.2018.01.020"
}

Eljabo, N., Nikolić, N., Čarkić, J., Jelovac, D., Lazarević, M., Tanić, N.,& Milašin, J.. (2018). Genetic and epigenetic alterations in the tumour, tumour margins, and normal buccal mucosa of patients with oral cancer. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 47(8), 976-982.
https://doi.org/10.1016/j.ijom.2018.01.020

Eljabo N, Nikolić N, Čarkić J, Jelovac D, Lazarević M, Tanić N, Milašin J. Genetic and epigenetic alterations in the tumour, tumour margins, and normal buccal mucosa of patients with oral cancer. in International Journal of Oral & Maxillofacial Surgery. 2018;47(8):976-982.
doi:10.1016/j.ijom.2018.01.020 .

Eljabo, Najib, Nikolić, Nadja, Čarkić, Jelena, Jelovac, Drago, Lazarević, M., Tanić, Nasta, Milašin, Jelena, "Genetic and epigenetic alterations in the tumour, tumour margins, and normal buccal mucosa of patients with oral cancer" in International Journal of Oral & Maxillofacial Surgery, 47, no. 8 (2018):976-982,
https://doi.org/10.1016/j.ijom.2018.01.020 . .

TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Trišić, Dijana
AU  - Toljić, Boško
AU  - Simonović, Jelena
AU  - Nikolić, Nadja
AU  - Miković, Nikola
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2271
AB  - Purpose: Recent evidence suggests that small subpopulations of stem-like cells are accountable for tumour initiation, progression and metastasis. Until now, studies were focused exclusively on the characterization of these cell populations within the tumour itself, while tumour margins were neglected, although it is known that the histological and molecular status of tumour margins may play a significant role in the course of the disease. Therefore, the aims of the study were to isolate cells from oral squamous cell carcinomas and their respective margins, to characterize these cells using specific markers, to assess their self-renewal potential and determine their chemoresistance. Methods: Cell cultures were obtained from 12 tissue specimens (6 tumours and 6 margins). Total RNA was extracted and gene expression analysis was done by real-time PCR (RTPCR). Flow cytometry, immunocytometry, sphere formation and MTT assays were also applied. Results: With minor differences, cells originating from both tumours and tumour margins showed the presence of stem cell markers CD133, Nanog, Sox2, CD44, and Oct4, had the capacity to form spheroids and showed chemoresistance. Conclusions: Subpopulations of margin cells appeared to have sternness properties which might raise the question of re-evaluation of optimal surgical management.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma
VL  - 23
IS  - 6
SP  - 1686
EP  - 1692
UR  - https://hdl.handle.net/21.15107/rcub_smile_2271
ER  - 

@article{
author = "Lazarević, Miloš and Milošević, Maja and Trišić, Dijana and Toljić, Boško and Simonović, Jelena and Nikolić, Nadja and Miković, Nikola and Jelovac, Drago and Petrović, Milan and Vukadinović, Miroslav and Milašin, Jelena",
year = "2018",
abstract = "Purpose: Recent evidence suggests that small subpopulations of stem-like cells are accountable for tumour initiation, progression and metastasis. Until now, studies were focused exclusively on the characterization of these cell populations within the tumour itself, while tumour margins were neglected, although it is known that the histological and molecular status of tumour margins may play a significant role in the course of the disease. Therefore, the aims of the study were to isolate cells from oral squamous cell carcinomas and their respective margins, to characterize these cells using specific markers, to assess their self-renewal potential and determine their chemoresistance. Methods: Cell cultures were obtained from 12 tissue specimens (6 tumours and 6 margins). Total RNA was extracted and gene expression analysis was done by real-time PCR (RTPCR). Flow cytometry, immunocytometry, sphere formation and MTT assays were also applied. Results: With minor differences, cells originating from both tumours and tumour margins showed the presence of stem cell markers CD133, Nanog, Sox2, CD44, and Oct4, had the capacity to form spheroids and showed chemoresistance. Conclusions: Subpopulations of margin cells appeared to have sternness properties which might raise the question of re-evaluation of optimal surgical management.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma",
volume = "23",
number = "6",
pages = "1686-1692",
url = "https://hdl.handle.net/21.15107/rcub_smile_2271"
}

Lazarević, M., Milošević, M., Trišić, D., Toljić, B., Simonović, J., Nikolić, N., Miković, N., Jelovac, D., Petrović, M., Vukadinović, M.,& Milašin, J.. (2018). Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(6), 1686-1692.
https://hdl.handle.net/21.15107/rcub_smile_2271

Lazarević M, Milošević M, Trišić D, Toljić B, Simonović J, Nikolić N, Miković N, Jelovac D, Petrović M, Vukadinović M, Milašin J. Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma. in Journal of BUON. 2018;23(6):1686-1692.
https://hdl.handle.net/21.15107/rcub_smile_2271 .

Lazarević, Miloš, Milošević, Maja, Trišić, Dijana, Toljić, Boško, Simonović, Jelena, Nikolić, Nadja, Miković, Nikola, Jelovac, Drago, Petrović, Milan, Vukadinović, Miroslav, Milašin, Jelena, "Putative cancer stem cells are present in surgical margins of oral squamous cell carcinoma" in Journal of BUON, 23, no. 6 (2018):1686-1692,
https://hdl.handle.net/21.15107/rcub_smile_2271 .

TY  - JOUR
AU  - Ilić, Branislav
AU  - Nikolić, Nadja
AU  - Andrić, Miroslav
AU  - Jelovac, Drago
AU  - Miličić, Biljana
AU  - Jozić, Tanja
AU  - Krstić, Slobodan
AU  - Milašin, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2190
AB  - BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P  lt  0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P  lt  0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development
VL  - 46
IS  - 4
SP  - 292
EP  - 296
DO  - 10.1111/jop.12564
ER  - 

@article{
author = "Ilić, Branislav and Nikolić, Nadja and Andrić, Miroslav and Jelovac, Drago and Miličić, Biljana and Jozić, Tanja and Krstić, Slobodan and Milašin, Jelena",
year = "2017",
abstract = "BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P  lt  0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P  lt  0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development",
volume = "46",
number = "4",
pages = "292-296",
doi = "10.1111/jop.12564"
}

Ilić, B., Nikolić, N., Andrić, M., Jelovac, D., Miličić, B., Jozić, T., Krstić, S.,& Milašin, J.. (2017). TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 46(4), 292-296.
https://doi.org/10.1111/jop.12564

Ilić B, Nikolić N, Andrić M, Jelovac D, Miličić B, Jozić T, Krstić S, Milašin J. TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine. 2017;46(4):292-296.
doi:10.1111/jop.12564 .

Ilić, Branislav, Nikolić, Nadja, Andrić, Miroslav, Jelovac, Drago, Miličić, Biljana, Jozić, Tanja, Krstić, Slobodan, Milašin, Jelena, "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development" in Journal of Oral Pathology & Medicine, 46, no. 4 (2017):292-296,
https://doi.org/10.1111/jop.12564 . .

TY  - JOUR
AU  - Antić, Svetlana
AU  - Miličić, Biljana
AU  - Jelovac, Drago
AU  - Đurić, Marija
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2092
AB  - BackgroundPrevious studies have shown the influence of the mandibular third molar on mandibular angle and condylar fractures, but have not comparatively analyzed the impact of the injury mechanism on these fractures. The purpose of this study was to evaluate the influence of the lower third molar (M3) and injury-related factors (fracture etiology and site of impact of the traumatic force) on the risk of mandibular angle and condylar fractures. Material and methodsThe study included 615 patients who sustained a mandibular fracture in a 13-year period (from January 2000 to December 2013). The independent variables were presence, position and the root number of the M3, fracture etiology, and site of impact of the force. The outcome variables were mandibular angle and condylar fractures. Other variables included in the study were patients' gender and age. The data were analyzed using the chi-square test. Univariate and multivariate binary logistic regression analyses were used to evaluate the relationship between angle and condylar fractures and to show potential determinants. ResultsAngle fractures were significantly influenced by the M3, site of impact, and age, but the main predictors were the eruption status and vertical position of the M3 (classified by Pell and Gregory) and site of impact of the force. Condylar fractures were significantly influenced by the M3 and site of impact of the force, but only the last showed as a predictor. ConclusionsFactors related to the M3 showed more significant influence on angle fractures than on condylar fractures.
PB  - Wiley, Hoboken
T2  - Dental Traumatology
T1  - Impact of the lower third molar and injury mechanism on the risk of mandibular angle and condylar fractures
VL  - 32
IS  - 4
SP  - 286
EP  - 295
DO  - 10.1111/edt.12259
ER  - 

@article{
author = "Antić, Svetlana and Miličić, Biljana and Jelovac, Drago and Đurić, Marija",
year = "2016",
abstract = "BackgroundPrevious studies have shown the influence of the mandibular third molar on mandibular angle and condylar fractures, but have not comparatively analyzed the impact of the injury mechanism on these fractures. The purpose of this study was to evaluate the influence of the lower third molar (M3) and injury-related factors (fracture etiology and site of impact of the traumatic force) on the risk of mandibular angle and condylar fractures. Material and methodsThe study included 615 patients who sustained a mandibular fracture in a 13-year period (from January 2000 to December 2013). The independent variables were presence, position and the root number of the M3, fracture etiology, and site of impact of the force. The outcome variables were mandibular angle and condylar fractures. Other variables included in the study were patients' gender and age. The data were analyzed using the chi-square test. Univariate and multivariate binary logistic regression analyses were used to evaluate the relationship between angle and condylar fractures and to show potential determinants. ResultsAngle fractures were significantly influenced by the M3, site of impact, and age, but the main predictors were the eruption status and vertical position of the M3 (classified by Pell and Gregory) and site of impact of the force. Condylar fractures were significantly influenced by the M3 and site of impact of the force, but only the last showed as a predictor. ConclusionsFactors related to the M3 showed more significant influence on angle fractures than on condylar fractures.",
publisher = "Wiley, Hoboken",
journal = "Dental Traumatology",
title = "Impact of the lower third molar and injury mechanism on the risk of mandibular angle and condylar fractures",
volume = "32",
number = "4",
pages = "286-295",
doi = "10.1111/edt.12259"
}

Antić, S., Miličić, B., Jelovac, D.,& Đurić, M.. (2016). Impact of the lower third molar and injury mechanism on the risk of mandibular angle and condylar fractures. in Dental Traumatology
Wiley, Hoboken., 32(4), 286-295.
https://doi.org/10.1111/edt.12259

Antić S, Miličić B, Jelovac D, Đurić M. Impact of the lower third molar and injury mechanism on the risk of mandibular angle and condylar fractures. in Dental Traumatology. 2016;32(4):286-295.
doi:10.1111/edt.12259 .

Antić, Svetlana, Miličić, Biljana, Jelovac, Drago, Đurić, Marija, "Impact of the lower third molar and injury mechanism on the risk of mandibular angle and condylar fractures" in Dental Traumatology, 32, no. 4 (2016):286-295,
https://doi.org/10.1111/edt.12259 . .

TY  - JOUR
AU  - Jelovac, Drago
AU  - Tepavčević, Zvezdana
AU  - Nikolić, Nadja
AU  - Ilić, Branislav
AU  - Eljabo, Najib
AU  - Popović, Branka
AU  - Čarkić, Jelena
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2180
AB  - The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P = 0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma
VL  - 45
IS  - 6
SP  - 700
EP  - 705
DO  - 10.1016/j.ijom.2015.11.014
ER  - 

@article{
author = "Jelovac, Drago and Tepavčević, Zvezdana and Nikolić, Nadja and Ilić, Branislav and Eljabo, Najib and Popović, Branka and Čarkić, Jelena and Konstantinović, Vitomir and Vukadinović, Miroslav and Miličić, Biljana and Milašin, Jelena",
year = "2016",
abstract = "The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P = 0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma",
volume = "45",
number = "6",
pages = "700-705",
doi = "10.1016/j.ijom.2015.11.014"
}

Jelovac, D., Tepavčević, Z., Nikolić, N., Ilić, B., Eljabo, N., Popović, B., Čarkić, J., Konstantinović, V., Vukadinović, M., Miličić, B.,& Milašin, J.. (2016). The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 45(6), 700-705.
https://doi.org/10.1016/j.ijom.2015.11.014

Jelovac D, Tepavčević Z, Nikolić N, Ilić B, Eljabo N, Popović B, Čarkić J, Konstantinović V, Vukadinović M, Miličić B, Milašin J. The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery. 2016;45(6):700-705.
doi:10.1016/j.ijom.2015.11.014 .

Jelovac, Drago, Tepavčević, Zvezdana, Nikolić, Nadja, Ilić, Branislav, Eljabo, Najib, Popović, Branka, Čarkić, Jelena, Konstantinović, Vitomir, Vukadinović, Miroslav, Miličić, Biljana, Milašin, Jelena, "The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma" in International Journal of Oral & Maxillofacial Surgery, 45, no. 6 (2016):700-705,
https://doi.org/10.1016/j.ijom.2015.11.014 . .

TY  - THES
AU  - Jelovac, Drago
PY  - 2015
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=2703
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:10825/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47603983
UR  - http://nardus.mpn.gov.rs/123456789/5061
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/984
AB  - Karcinom pločasto slojevitog epitela usne duplje - oralni planocelularni karcinom (OPK) je invazivna patološka lezija epitela različitog stepena skvamozne diferencijacije koji se odlikuje ranim i ekstenzivnim metastazama. Ključni faktor za tok bolesti i ishod hirurškog lečenja kod pacijenata sa planocelularnim karcinomom glave i vrata je pravovremena dijagnoza i adekvatno hirurško lečenje. Postoje brojni dokazi da je prisustvo malignih ćelija u hirurškim marginama u direktnoj vezi sa povećanim rizikom za razvoj recidiva bolesti kao i manjom stopom preživljavanja. Za sada ne postoje jedinstveni kriterijumi koji definišu šta je „čista“ odnosno histološki negativna hirurška margina kod OPK. U literaturi ima mnogo kontradiktornih podataka vezanih za uticaj statusa margina na ishod hirurškog lečenja zbog ograničenog dometa histopatološke analize. Predmet ove studije je molekularno-genetička analiza histološki negativnih margina OPK, kao potencijalno relevantan parametar sa stanovišta procene ishoda hirurške intervencije. Istraživanje je obuhvatilo analizu gena TP53, H-ras, c-myc i c-erb B2 koji imaju značajnu ulogu u malignoj transformaciji ćelija. Nakon histopatološke verifikacije da u graničnom tkivu nema prodora malignih ćelija, pristupilo se daljoj molekularno genetičkoj analizi graničnog tkiva. Studijom je obuhvaćeno 50 pacijenata. Skrining tačkastih mutacija u egzonima 5-7 TP53gena i H- ras gena, urađen je pomoću PCR-SSCP metode (lančana reakcija polimeraze i konformacioni polimorfizam jednolančane DNK) a uzorci koji su pokazali izmenjenu elektroforetsku pokretljivost su (komercijalno) sekvencirani. Dobijene sekvence upoređivane su sa bazom podataka NCBI GeneBank. Za analizu genske amplifikacije (c-myc i c-erbB2) korišćena je metoda diferencijalnog PCR-a, kao i metoda relativne kvantifikacije na real-time PCR aparatu, upotrebom kontrolnog («house-keeping»)gena...
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Analysis of alterations of oncogenes and tumorsuppressor genes in histologically free margins of oral squamous cell carcinoma
T1  - Analiza alteracija onkogena i tumorsupresornih gena u histološki negativnim marginama planocelularnih karcinoma usne duplje
UR  - https://hdl.handle.net/21.15107/rcub_nardus_5061
ER  - 

@phdthesis{
author = "Jelovac, Drago",
year = "2015",
abstract = "Karcinom pločasto slojevitog epitela usne duplje - oralni planocelularni karcinom (OPK) je invazivna patološka lezija epitela različitog stepena skvamozne diferencijacije koji se odlikuje ranim i ekstenzivnim metastazama. Ključni faktor za tok bolesti i ishod hirurškog lečenja kod pacijenata sa planocelularnim karcinomom glave i vrata je pravovremena dijagnoza i adekvatno hirurško lečenje. Postoje brojni dokazi da je prisustvo malignih ćelija u hirurškim marginama u direktnoj vezi sa povećanim rizikom za razvoj recidiva bolesti kao i manjom stopom preživljavanja. Za sada ne postoje jedinstveni kriterijumi koji definišu šta je „čista“ odnosno histološki negativna hirurška margina kod OPK. U literaturi ima mnogo kontradiktornih podataka vezanih za uticaj statusa margina na ishod hirurškog lečenja zbog ograničenog dometa histopatološke analize. Predmet ove studije je molekularno-genetička analiza histološki negativnih margina OPK, kao potencijalno relevantan parametar sa stanovišta procene ishoda hirurške intervencije. Istraživanje je obuhvatilo analizu gena TP53, H-ras, c-myc i c-erb B2 koji imaju značajnu ulogu u malignoj transformaciji ćelija. Nakon histopatološke verifikacije da u graničnom tkivu nema prodora malignih ćelija, pristupilo se daljoj molekularno genetičkoj analizi graničnog tkiva. Studijom je obuhvaćeno 50 pacijenata. Skrining tačkastih mutacija u egzonima 5-7 TP53gena i H- ras gena, urađen je pomoću PCR-SSCP metode (lančana reakcija polimeraze i konformacioni polimorfizam jednolančane DNK) a uzorci koji su pokazali izmenjenu elektroforetsku pokretljivost su (komercijalno) sekvencirani. Dobijene sekvence upoređivane su sa bazom podataka NCBI GeneBank. Za analizu genske amplifikacije (c-myc i c-erbB2) korišćena je metoda diferencijalnog PCR-a, kao i metoda relativne kvantifikacije na real-time PCR aparatu, upotrebom kontrolnog («house-keeping»)gena...",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Analysis of alterations of oncogenes and tumorsuppressor genes in histologically free margins of oral squamous cell carcinoma, Analiza alteracija onkogena i tumorsupresornih gena u histološki negativnim marginama planocelularnih karcinoma usne duplje",
url = "https://hdl.handle.net/21.15107/rcub_nardus_5061"
}

Jelovac, D.. (2015). Analysis of alterations of oncogenes and tumorsuppressor genes in histologically free margins of oral squamous cell carcinoma. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_nardus_5061

Jelovac D. Analysis of alterations of oncogenes and tumorsuppressor genes in histologically free margins of oral squamous cell carcinoma. 2015;.
https://hdl.handle.net/21.15107/rcub_nardus_5061 .

Jelovac, Drago, "Analysis of alterations of oncogenes and tumorsuppressor genes in histologically free margins of oral squamous cell carcinoma" (2015),
https://hdl.handle.net/21.15107/rcub_nardus_5061 .

TY  - JOUR
AU  - Jaćimović, Jelena
AU  - Krstev, Cvetana
AU  - Jelovac, Drago
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1992
AB  - This paper presents an automatic de-identification system for Serbian, based on the adaptation of the existing rule-based named entity recognition system. Built on a finite-state methodology and lexical resources, the system is designed to detect and replace all the explicit personal protected health information present in the medical narrative texts, while still preserving all the relevant medical concepts. The results of a preliminary evaluation demonstrate the usefulness of this method both in preserving patient privacy and the de-identified document interoperability.
PB  - Slovensko Drustvo Informatika, Ljubljana
T2  - Informatica - Journal of Computing & Informatics
T1  - A Rule-Based System for Automatic De-identification of Medical Narrative Texts
VL  - 39
IS  - 1
SP  - 43
EP  - 51
UR  - https://hdl.handle.net/21.15107/rcub_smile_1992
ER  - 

@article{
author = "Jaćimović, Jelena and Krstev, Cvetana and Jelovac, Drago",
year = "2015",
abstract = "This paper presents an automatic de-identification system for Serbian, based on the adaptation of the existing rule-based named entity recognition system. Built on a finite-state methodology and lexical resources, the system is designed to detect and replace all the explicit personal protected health information present in the medical narrative texts, while still preserving all the relevant medical concepts. The results of a preliminary evaluation demonstrate the usefulness of this method both in preserving patient privacy and the de-identified document interoperability.",
publisher = "Slovensko Drustvo Informatika, Ljubljana",
journal = "Informatica - Journal of Computing & Informatics",
title = "A Rule-Based System for Automatic De-identification of Medical Narrative Texts",
volume = "39",
number = "1",
pages = "43-51",
url = "https://hdl.handle.net/21.15107/rcub_smile_1992"
}

Jaćimović, J., Krstev, C.,& Jelovac, D.. (2015). A Rule-Based System for Automatic De-identification of Medical Narrative Texts. in Informatica - Journal of Computing & Informatics
Slovensko Drustvo Informatika, Ljubljana., 39(1), 43-51.
https://hdl.handle.net/21.15107/rcub_smile_1992

Jaćimović J, Krstev C, Jelovac D. A Rule-Based System for Automatic De-identification of Medical Narrative Texts. in Informatica - Journal of Computing & Informatics. 2015;39(1):43-51.
https://hdl.handle.net/21.15107/rcub_smile_1992 .

Jaćimović, Jelena, Krstev, Cvetana, Jelovac, Drago, "A Rule-Based System for Automatic De-identification of Medical Narrative Texts" in Informatica - Journal of Computing & Informatics, 39, no. 1 (2015):43-51,
https://hdl.handle.net/21.15107/rcub_smile_1992 .

TY  - JOUR
AU  - Gavrić, Miodrag
AU  - Antić, Svetlana
AU  - Jelovac, Drago
AU  - Zarev, Anita I.
AU  - Petrović, Milan
AU  - Golubović, Mileta
AU  - Antunović, Marija
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1906
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis
T1  - Osteonekroza vilica kao ozbiljan neželjeni efekat terapije bisfosfonatima i njegova nejasna etiopatogeneza
VL  - 71
IS  - 8
SP  - 772
EP  - 776
DO  - 10.2298/VSP121211025G
ER  - 

@article{
author = "Gavrić, Miodrag and Antić, Svetlana and Jelovac, Drago and Zarev, Anita I. and Petrović, Milan and Golubović, Mileta and Antunović, Marija",
year = "2014",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis, Osteonekroza vilica kao ozbiljan neželjeni efekat terapije bisfosfonatima i njegova nejasna etiopatogeneza",
volume = "71",
number = "8",
pages = "772-776",
doi = "10.2298/VSP121211025G"
}

Gavrić, M., Antić, S., Jelovac, D., Zarev, A. I., Petrović, M., Golubović, M.,& Antunović, M.. (2014). Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(8), 772-776.
https://doi.org/10.2298/VSP121211025G

Gavrić M, Antić S, Jelovac D, Zarev AI, Petrović M, Golubović M, Antunović M. Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis. in Vojnosanitetski pregled. 2014;71(8):772-776.
doi:10.2298/VSP121211025G .

Gavrić, Miodrag, Antić, Svetlana, Jelovac, Drago, Zarev, Anita I., Petrović, Milan, Golubović, Mileta, Antunović, Marija, "Osteonecrosis of the jaw as a serious adverse effect of bisphosphonate therapy and its indistinct etiopathogenesis" in Vojnosanitetski pregled, 71, no. 8 (2014):772-776,
https://doi.org/10.2298/VSP121211025G . .

TY  - CONF
AU  - Jaćimović, Jelena
AU  - Krstev, Cvetana
AU  - Jelovac, Drago
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2533
AB  - This paper presents an automatic de-identification system for Serbian, grounded on a rapid adaptation of the existing named entity recognition system. Based on a finite-state methodology and lexical resources, the system is designed to detect and replace all explicit personal protected health information present in the medical narrative texts, while still preserving all the relevant medical concepts. The results of a preliminary evaluation demonstrate the usefulness of this method both in preserving patient privacy and the de- identified document interoperability.
PB  - Jožef Stefan Institute, Ljubljana, Slovenia
C3  - Proceedings of the 17th International Multiconference INFORMATION SOCIETY – IS 2014, Language Technologies, October 9th−10th, 2014, Ljubljana, Slovenia
T1  - Automatic de-identification of protected health information
VL  - G
SP  - 73
EP  - 78
UR  - https://hdl.handle.net/21.15107/rcub_smile_2533
ER  - 

@conference{
author = "Jaćimović, Jelena and Krstev, Cvetana and Jelovac, Drago",
year = "2014",
abstract = "This paper presents an automatic de-identification system for Serbian, grounded on a rapid adaptation of the existing named entity recognition system. Based on a finite-state methodology and lexical resources, the system is designed to detect and replace all explicit personal protected health information present in the medical narrative texts, while still preserving all the relevant medical concepts. The results of a preliminary evaluation demonstrate the usefulness of this method both in preserving patient privacy and the de- identified document interoperability.",
publisher = "Jožef Stefan Institute, Ljubljana, Slovenia",
journal = "Proceedings of the 17th International Multiconference INFORMATION SOCIETY – IS 2014, Language Technologies, October 9th−10th, 2014, Ljubljana, Slovenia",
title = "Automatic de-identification of protected health information",
volume = "G",
pages = "73-78",
url = "https://hdl.handle.net/21.15107/rcub_smile_2533"
}

Jaćimović, J., Krstev, C.,& Jelovac, D.. (2014). Automatic de-identification of protected health information. in Proceedings of the 17th International Multiconference INFORMATION SOCIETY – IS 2014, Language Technologies, October 9th−10th, 2014, Ljubljana, Slovenia
Jožef Stefan Institute, Ljubljana, Slovenia., G, 73-78.
https://hdl.handle.net/21.15107/rcub_smile_2533

Jaćimović J, Krstev C, Jelovac D. Automatic de-identification of protected health information. in Proceedings of the 17th International Multiconference INFORMATION SOCIETY – IS 2014, Language Technologies, October 9th−10th, 2014, Ljubljana, Slovenia. 2014;G:73-78.
https://hdl.handle.net/21.15107/rcub_smile_2533 .

Jaćimović, Jelena, Krstev, Cvetana, Jelovac, Drago, "Automatic de-identification of protected health information" in Proceedings of the 17th International Multiconference INFORMATION SOCIETY – IS 2014, Language Technologies, October 9th−10th, 2014, Ljubljana, Slovenia, G (2014):73-78,
https://hdl.handle.net/21.15107/rcub_smile_2533 .

TY  - JOUR
AU  - Kostić, Marija
AU  - Nikolić, Nadja
AU  - Ilić, Branislav
AU  - Jelovac, Drago
AU  - Trakilović, Slobodanka
AU  - Božović, Maja
AU  - Milašin, Jelena
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1793
AB  - Tumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors. We have investigated whether polymorphisms in TNF-alpha (-308G>A), TNF receptor 1 (36A>G) and TNF receptor 2 (676T>G) genes modulate the susceptibility for oral squamous cell carcinomas (OSCCs) and basal cell carcinomas (BCCs) of the skin, two frequent types of head and neck cancers. Genotyping was done on 50 OSCC patients, 50 BCC patients and 60 healthy individuals, using PCR/RFLP. A significant difference in genotype and allele frequencies was found between patients and controls for the TNF-R2 polymorphism, in both OSCC and BCC. There was no statistically significant difference between patients and controls for TNF-alpha and TNF-R1 polymorphisms. Carriers of G allele had an approximately 2.5- and 5-fold higher risk for OSCC and BCC, respectively, in the Serbian population.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population
VL  - 65
IS  - 1
SP  - 387
EP  - 393
DO  - 10.2298/ABS1301387K
ER  - 

@article{
author = "Kostić, Marija and Nikolić, Nadja and Ilić, Branislav and Jelovac, Drago and Trakilović, Slobodanka and Božović, Maja and Milašin, Jelena",
year = "2013",
abstract = "Tumor necrosis factor (TNF) which exerts its effects through two different receptors known as TNF-R1 and TNF-R2, is a major proinflammatory cytokine involved in the pathogenesis of different types of tumors. We have investigated whether polymorphisms in TNF-alpha (-308G>A), TNF receptor 1 (36A>G) and TNF receptor 2 (676T>G) genes modulate the susceptibility for oral squamous cell carcinomas (OSCCs) and basal cell carcinomas (BCCs) of the skin, two frequent types of head and neck cancers. Genotyping was done on 50 OSCC patients, 50 BCC patients and 60 healthy individuals, using PCR/RFLP. A significant difference in genotype and allele frequencies was found between patients and controls for the TNF-R2 polymorphism, in both OSCC and BCC. There was no statistically significant difference between patients and controls for TNF-alpha and TNF-R1 polymorphisms. Carriers of G allele had an approximately 2.5- and 5-fold higher risk for OSCC and BCC, respectively, in the Serbian population.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population",
volume = "65",
number = "1",
pages = "387-393",
doi = "10.2298/ABS1301387K"
}

Kostić, M., Nikolić, N., Ilić, B., Jelovac, D., Trakilović, S., Božović, M.,& Milašin, J.. (2013). Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 65(1), 387-393.
https://doi.org/10.2298/ABS1301387K

Kostić M, Nikolić N, Ilić B, Jelovac D, Trakilović S, Božović M, Milašin J. Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population. in Archives of Biological Sciences. 2013;65(1):387-393.
doi:10.2298/ABS1301387K .

Kostić, Marija, Nikolić, Nadja, Ilić, Branislav, Jelovac, Drago, Trakilović, Slobodanka, Božović, Maja, Milašin, Jelena, "Association of TNF-R2 (676T>G) single nucleotide polymorphism with head and neck cancer risk in the Serbian population" in Archives of Biological Sciences, 65, no. 1 (2013):387-393,
https://doi.org/10.2298/ABS1301387K . .

TY  - JOUR
AU  - Golubović, Mileta
AU  - Petrović, Milan
AU  - Jelovac, Drago
AU  - Nenezić, Dragoslav U.
AU  - Antunović, Marija
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1718
AB  - Introduction. Ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior. Their frequency is low (they account for 1% of all head and neck tumors and about 11% of tumors of dental origin). Malignant variations of ameloblastoma are malignant ameloblastoma and ameloblastic carcinoma. They constitute less than 1% of all ameloblastomas. We presented a case of malignant ameloblastoma of the mandible with neck metastasis. Case report. A patient, aged 72, presented with the following symptoms: pain in the lower jaw, swelling in the left submandibular area and difficult mouth opening. The patient was admitted to the Department of Oral and Maxillofacial Surgery, Clinical Center of Montenegro, two months after he had noticed the symptoms. Panoramic radiography (OPG) showed that both jaws were partially toothless with terminal stage of periodontitis of the remaining teeth. Also, OPG showed sharply limited semicircular defect in the retromolar region and along the front edge of the mandible rami. Conventional histopathologic examination of the neck masses showed malignant ameloblastoma which contained central fields of squamous differentiation. Immunoreactivity of several markers was determined using immunohistochemical analyses. After these diagnostic methods a definite histopathology diagnosis was made: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Conclusion. It is not possible to distinguish conventional, ie intraosseous, ameloblastoma from malignant ameloblastoma according to histopathologic features. It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological and pathohistological diagnostic procedures, such as immunohistochemical analysis. A timely and correct diagnosis and treatment of malignant ameloblastoma require a multidisciplinary approach.
AB  - Uvod. Ameloblastomi su odontogeni epitelni tumori, lokalno invazivni, sporog rasta, i u većini slučajeva pokazuju benigno ponašanje. Veoma su rijetki. Njihova učestalost je 1% u grupi tumora glave i vrata, kao i 11% kod tumora koji potiču od zubnih tkiva. Maligne varijante ameloblastoma su maligni ameloblastom i ameloblastički karcinom. Oni čine manje od 1% svih ameloblastoma. U radu je prikazan bolesnik sa malignim ameloblastomom donje vilice sa metastazom na vratu. Prikaz bolesnika. Prve subjektivne tegobe bolesnika, starog 72 godine, manifestovale su se kao bolovi u predelu donje vilice, otok u podviličnom predelu sa leve strane i otežano otvaranje usta. Bolesnik je primljen u Odeljenje oralne i maksilofacijalne hirurgije Kliničkog centra Crne Gore dva meseca nakon što je primetio prve tegobe. Ortopantomografski snimak pokazao je suptotalnu bezubost obeju vilica sa terminalnim stadijumom parodontopatije na preostalim zubima. U retromolarnoj regiji i duž prednje ivice ramusa donje vilice, uočen je jasno ograničen polukružni defekt. Biopsija promene na vratu pokazala je metastazu malignog ameloblastoma, sa prisutnim centralnim poljima skvamozne diferencijacije. Imunohistohemijskom analizom određivana je imunoreaktivnost više markera. Nakon ovih dijagnostičkih metoda postavljena je definitivna patohistološka dijagnoza: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Zaključak. Na osnovu histopatološkog nalaza nije moguće razlikovati konvencionalni, tj. intraosealni, ameloblastom od malignog ameloblastoma. Zbog toga je potrebno obratiti posebnu pažnju, naro čito kod bolesnika starijeg životnog doba, i sprovesti sve dodatne kliničke, radiološke i histopatološke, ali i imunohistohemijske dijagnostičke procedure. Za postavljanje blagovremene i tačne dijagnoze, kao i sprovođenje adekvatnog terapijskog tretmana malignog ameloblastoma, neophodan je multidisciplinarni pristup.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma
T1  - Metastaza malignog ameloblastoma na vratu - radiološka i patohistološka dilema
VL  - 69
IS  - 5
SP  - 444
EP  - 448
DO  - 10.2298/VSP1205444G
ER  - 

@article{
author = "Golubović, Mileta and Petrović, Milan and Jelovac, Drago and Nenezić, Dragoslav U. and Antunović, Marija",
year = "2012",
abstract = "Introduction. Ameloblastomas are odontogenic epithelial, locally invasive tumors of slow growth and mostly of benign behavior. Their frequency is low (they account for 1% of all head and neck tumors and about 11% of tumors of dental origin). Malignant variations of ameloblastoma are malignant ameloblastoma and ameloblastic carcinoma. They constitute less than 1% of all ameloblastomas. We presented a case of malignant ameloblastoma of the mandible with neck metastasis. Case report. A patient, aged 72, presented with the following symptoms: pain in the lower jaw, swelling in the left submandibular area and difficult mouth opening. The patient was admitted to the Department of Oral and Maxillofacial Surgery, Clinical Center of Montenegro, two months after he had noticed the symptoms. Panoramic radiography (OPG) showed that both jaws were partially toothless with terminal stage of periodontitis of the remaining teeth. Also, OPG showed sharply limited semicircular defect in the retromolar region and along the front edge of the mandible rami. Conventional histopathologic examination of the neck masses showed malignant ameloblastoma which contained central fields of squamous differentiation. Immunoreactivity of several markers was determined using immunohistochemical analyses. After these diagnostic methods a definite histopathology diagnosis was made: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Conclusion. It is not possible to distinguish conventional, ie intraosseous, ameloblastoma from malignant ameloblastoma according to histopathologic features. It is necessary to pay special attention, especially in elderly patients, and to carry out further clinical, radiological and pathohistological diagnostic procedures, such as immunohistochemical analysis. A timely and correct diagnosis and treatment of malignant ameloblastoma require a multidisciplinary approach., Uvod. Ameloblastomi su odontogeni epitelni tumori, lokalno invazivni, sporog rasta, i u većini slučajeva pokazuju benigno ponašanje. Veoma su rijetki. Njihova učestalost je 1% u grupi tumora glave i vrata, kao i 11% kod tumora koji potiču od zubnih tkiva. Maligne varijante ameloblastoma su maligni ameloblastom i ameloblastički karcinom. Oni čine manje od 1% svih ameloblastoma. U radu je prikazan bolesnik sa malignim ameloblastomom donje vilice sa metastazom na vratu. Prikaz bolesnika. Prve subjektivne tegobe bolesnika, starog 72 godine, manifestovale su se kao bolovi u predelu donje vilice, otok u podviličnom predelu sa leve strane i otežano otvaranje usta. Bolesnik je primljen u Odeljenje oralne i maksilofacijalne hirurgije Kliničkog centra Crne Gore dva meseca nakon što je primetio prve tegobe. Ortopantomografski snimak pokazao je suptotalnu bezubost obeju vilica sa terminalnim stadijumom parodontopatije na preostalim zubima. U retromolarnoj regiji i duž prednje ivice ramusa donje vilice, uočen je jasno ograničen polukružni defekt. Biopsija promene na vratu pokazala je metastazu malignog ameloblastoma, sa prisutnim centralnim poljima skvamozne diferencijacije. Imunohistohemijskom analizom određivana je imunoreaktivnost više markera. Nakon ovih dijagnostičkih metoda postavljena je definitivna patohistološka dijagnoza: Ameloblastoma metastaticum in textus fibroadiposus regio colli (typus acanthomatosus). Zaključak. Na osnovu histopatološkog nalaza nije moguće razlikovati konvencionalni, tj. intraosealni, ameloblastom od malignog ameloblastoma. Zbog toga je potrebno obratiti posebnu pažnju, naro čito kod bolesnika starijeg životnog doba, i sprovesti sve dodatne kliničke, radiološke i histopatološke, ali i imunohistohemijske dijagnostičke procedure. Za postavljanje blagovremene i tačne dijagnoze, kao i sprovođenje adekvatnog terapijskog tretmana malignog ameloblastoma, neophodan je multidisciplinarni pristup.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma, Metastaza malignog ameloblastoma na vratu - radiološka i patohistološka dilema",
volume = "69",
number = "5",
pages = "444-448",
doi = "10.2298/VSP1205444G"
}

Golubović, M., Petrović, M., Jelovac, D., Nenezić, D. U.,& Antunović, M.. (2012). Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 69(5), 444-448.
https://doi.org/10.2298/VSP1205444G

Golubović M, Petrović M, Jelovac D, Nenezić DU, Antunović M. Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma. in Vojnosanitetski pregled. 2012;69(5):444-448.
doi:10.2298/VSP1205444G .

Golubović, Mileta, Petrović, Milan, Jelovac, Drago, Nenezić, Dragoslav U., Antunović, Marija, "Malignant ameloblastoma metastasis to the neck: Radiological and pathohistological dilemma" in Vojnosanitetski pregled, 69, no. 5 (2012):444-448,
https://doi.org/10.2298/VSP1205444G . .

TY  - JOUR
AU  - Brinkmann, Ole
AU  - Kastratović, Dragana A.
AU  - Dimitrijević, Milovan
AU  - Konstantinović, Vitomir
AU  - Jelovac, Drago
AU  - Antić, Jadranka
AU  - Nesić, Vladimir S.
AU  - Marković, Srđan Z.
AU  - Martinović, Željko
AU  - Akin, David
AU  - Spielmann, Nadine
AU  - Zhou, Hui
AU  - Wong, David T.
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1608
AB  - Early detection of oral squamous cell cancer (OSCC) is the key to improve the low 5-year survival rate. Using proteomic and genomic technologies we have previously discovered and validated salivary OSCC markers in American patients. The question arises whether these biomarkers are discriminatory in cohorts of different ethnic background. Six transcriptome (DUSP1, IL8, IL1B, OAZ1, SAT1, and S100P) and three proteome (IL1B, IL8, and M2BP) biomarkers were tested on 18 early and 17 late stage OSCC patients and 51 healthy controls with quantitative PCR and ELISA. Four transcriptome (IL8, IL1B, SAT1, and S100P) and all proteome biomarkers were significantly elevated (p  lt  0.05) in OSCC patients. The combination of markers yielded an AUC of 0.86, 0.85 and 0.88 for OSCC total, T1-T2, and T3-T4, respectively. The sensitivity/specificity for OSCC total was 0.89/0.78, for T1-T2 0.67/0.96, and for T3-T4 0.82/0.84. In conclusion, seven of the nine salivary biomarkers (three proteins and four mRNAs) were validated and performed strongest in late stage cancer. Patient-based salivary diagnostics is a highly promising approach for OSCC detection. This study shows that previously discovered and validated salivary OSCC biomarkers are discriminatory and reproducible in a different ethnic cohort. These findings support the feasibility to implement multi-center, multi-ethnicity clinical trials towards the pivotal validation of salivary biomarkers for OSCC detection.
PB  - Elsevier Science Bv, Amsterdam
T2  - Oral Oncology
T1  - Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population
VL  - 47
IS  - 1
SP  - 51
EP  - 55
DO  - 10.1016/j.oraloncology.2010.10.009
ER  - 

@article{
author = "Brinkmann, Ole and Kastratović, Dragana A. and Dimitrijević, Milovan and Konstantinović, Vitomir and Jelovac, Drago and Antić, Jadranka and Nesić, Vladimir S. and Marković, Srđan Z. and Martinović, Željko and Akin, David and Spielmann, Nadine and Zhou, Hui and Wong, David T.",
year = "2011",
abstract = "Early detection of oral squamous cell cancer (OSCC) is the key to improve the low 5-year survival rate. Using proteomic and genomic technologies we have previously discovered and validated salivary OSCC markers in American patients. The question arises whether these biomarkers are discriminatory in cohorts of different ethnic background. Six transcriptome (DUSP1, IL8, IL1B, OAZ1, SAT1, and S100P) and three proteome (IL1B, IL8, and M2BP) biomarkers were tested on 18 early and 17 late stage OSCC patients and 51 healthy controls with quantitative PCR and ELISA. Four transcriptome (IL8, IL1B, SAT1, and S100P) and all proteome biomarkers were significantly elevated (p  lt  0.05) in OSCC patients. The combination of markers yielded an AUC of 0.86, 0.85 and 0.88 for OSCC total, T1-T2, and T3-T4, respectively. The sensitivity/specificity for OSCC total was 0.89/0.78, for T1-T2 0.67/0.96, and for T3-T4 0.82/0.84. In conclusion, seven of the nine salivary biomarkers (three proteins and four mRNAs) were validated and performed strongest in late stage cancer. Patient-based salivary diagnostics is a highly promising approach for OSCC detection. This study shows that previously discovered and validated salivary OSCC biomarkers are discriminatory and reproducible in a different ethnic cohort. These findings support the feasibility to implement multi-center, multi-ethnicity clinical trials towards the pivotal validation of salivary biomarkers for OSCC detection.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Oral Oncology",
title = "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population",
volume = "47",
number = "1",
pages = "51-55",
doi = "10.1016/j.oraloncology.2010.10.009"
}

Brinkmann, O., Kastratović, D. A., Dimitrijević, M., Konstantinović, V., Jelovac, D., Antić, J., Nesić, V. S., Marković, S. Z., Martinović, Ž., Akin, D., Spielmann, N., Zhou, H.,& Wong, D. T.. (2011). Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. in Oral Oncology
Elsevier Science Bv, Amsterdam., 47(1), 51-55.
https://doi.org/10.1016/j.oraloncology.2010.10.009

Brinkmann O, Kastratović DA, Dimitrijević M, Konstantinović V, Jelovac D, Antić J, Nesić VS, Marković SZ, Martinović Ž, Akin D, Spielmann N, Zhou H, Wong DT. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. in Oral Oncology. 2011;47(1):51-55.
doi:10.1016/j.oraloncology.2010.10.009 .

Brinkmann, Ole, Kastratović, Dragana A., Dimitrijević, Milovan, Konstantinović, Vitomir, Jelovac, Drago, Antić, Jadranka, Nesić, Vladimir S., Marković, Srđan Z., Martinović, Željko, Akin, David, Spielmann, Nadine, Zhou, Hui, Wong, David T., "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population" in Oral Oncology, 47, no. 1 (2011):51-55,
https://doi.org/10.1016/j.oraloncology.2010.10.009 . .

TY  - JOUR
AU  - Konstantinović, Vitomir
AU  - Puzović, Dragana
AU  - Aničić, Boban
AU  - Jelovac, Drago
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1557
AB  - The aim of this article was the epidemiological, clinical, and forensic evaluation of the chainsaw, circular saw, and grinding saw maxillofacial injuries. A retrospective analysis of the medical records at the Clinic of Maxillofacial Surgery, School of Dentistry, University of Belgrade, was performed. A total of 133 patients were treated during a period of 19 years (1989-2008). Grinding saw injuries were more frequent (62%) in comparison to chainsaw and circular saw injuries that were present in 23% and 15% of patients, respectively. All injured individuals were men, and most of them were aged 31 to 40 years. Accident by self injuring was the only mechanism of all the analyzed injuries. There were no suicide or homicide attempts. Isolated injuries of the facial soft tissues, which were mainly lacerations, were present in most patients. Less frequently, soft tissues injuries were compounded with bone fractures of the face and teeth injuries. Surgical debridement, revision, and suturing were performed in all patients where only soft tissues were injured. Patients with compound injuries of the soft tissues, facial bones, and teeth were treated according to the common surgical protocol for the type of the injuries. Most often, these injuries were accidental without fatalities. The number of these injuries increased in the recent years owing to the "do-it-yourselfers" for home hobbies. To avoid these types of injuries, users should be carefully instructed, and attention should be paid to the use of accurately guarded saws and appropriate safety equipment.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Craniofacial Surgery
T1  - Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region
VL  - 21
IS  - 4
SP  - 1029
EP  - 1032
DO  - 10.1097/SCS.0b013e3181e432bd
ER  - 

@article{
author = "Konstantinović, Vitomir and Puzović, Dragana and Aničić, Boban and Jelovac, Drago",
year = "2010",
abstract = "The aim of this article was the epidemiological, clinical, and forensic evaluation of the chainsaw, circular saw, and grinding saw maxillofacial injuries. A retrospective analysis of the medical records at the Clinic of Maxillofacial Surgery, School of Dentistry, University of Belgrade, was performed. A total of 133 patients were treated during a period of 19 years (1989-2008). Grinding saw injuries were more frequent (62%) in comparison to chainsaw and circular saw injuries that were present in 23% and 15% of patients, respectively. All injured individuals were men, and most of them were aged 31 to 40 years. Accident by self injuring was the only mechanism of all the analyzed injuries. There were no suicide or homicide attempts. Isolated injuries of the facial soft tissues, which were mainly lacerations, were present in most patients. Less frequently, soft tissues injuries were compounded with bone fractures of the face and teeth injuries. Surgical debridement, revision, and suturing were performed in all patients where only soft tissues were injured. Patients with compound injuries of the soft tissues, facial bones, and teeth were treated according to the common surgical protocol for the type of the injuries. Most often, these injuries were accidental without fatalities. The number of these injuries increased in the recent years owing to the "do-it-yourselfers" for home hobbies. To avoid these types of injuries, users should be carefully instructed, and attention should be paid to the use of accurately guarded saws and appropriate safety equipment.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Craniofacial Surgery",
title = "Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region",
volume = "21",
number = "4",
pages = "1029-1032",
doi = "10.1097/SCS.0b013e3181e432bd"
}

Konstantinović, V., Puzović, D., Aničić, B.,& Jelovac, D.. (2010). Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region. in Journal of Craniofacial Surgery
Lippincott Williams & Wilkins, Philadelphia., 21(4), 1029-1032.
https://doi.org/10.1097/SCS.0b013e3181e432bd

Konstantinović V, Puzović D, Aničić B, Jelovac D. Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region. in Journal of Craniofacial Surgery. 2010;21(4):1029-1032.
doi:10.1097/SCS.0b013e3181e432bd .

Konstantinović, Vitomir, Puzović, Dragana, Aničić, Boban, Jelovac, Drago, "Epidemiological, Clinical, and Forensic Aspects of Chainsaw, Circular Saw, and Grinding Saw Injuries in the Maxillofacial Region" in Journal of Craniofacial Surgery, 21, no. 4 (2010):1029-1032,
https://doi.org/10.1097/SCS.0b013e3181e432bd . .

TY  - JOUR
AU  - Golubović, Mileta
AU  - Ašanin, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Antunović, Marija
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1536
AB  - The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor size among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter.
AB  - Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma
T1  - Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti
VL  - 67
IS  - 1
SP  - 19
EP  - 24
DO  - 10.2298/VSP1001019G
ER  - 

@article{
author = "Golubović, Mileta and Ašanin, Bogdan and Jelovac, Drago and Petrović, Milan and Antunović, Marija",
year = "2010",
abstract = "The most common malignancy of the lip is squamous cell carcinoma (SCC). In our population, according to epidemiological data, almost a half of all (45%) SCC of oral mucous tissue spreads over the lower and upper lip. The aim of this study was to estimate prognostic importance of histopathologic characteristics - histologic grade, nuclear grade and tumor size in relation to the appearance of lymph node metastases and relapse in SCC of the lip. Methods. In the retrospective- prospective study 70 cases of lower and upper lip SCC were analyzed. They were diagnosed from 2002 to 2006 in the Clinic of Maxillofacial Surgery, Clinical Center of Montenegro. The data about localization of the carcinomas, histopathologic characteristics and lymph node status were taken from medical files of the patients. The patients were followed up in a 3-year period and the disease relapse or/and metastatic disease appearance were registereds. Results. There was statistically significant difference in tumor size among the patients with and without disease relapse (p = 0.027). Logistic regression analysis showed that the tumor size is a statistically significant factor (R = 0.186; p = 0.011) for the appearance of regional lymph node metastases. Relative risk [exp (B)] for the appearance of regional lymph node metastases in relation to tumor size was 2.807. Conclusion. Histologic and nuclear grade of lip SCC are not prognostic factors for the appearance of the disease relapse and regional lymph node metastases. Tumor size is a predictive factor of the relapse appearance, as well as for lymph node metastases appearance. In clinical practice, tumor size is a factor that classifies patients with lip SCC into the groups of higher and smaller risk of relapse appearance and for lymph node metastases appearance. Our results suggest that, risk for lymph node metastases appearance increases 2.8 times with increasing of the tumor size over 2 cm in diameter., Uvod/Cilj. Planocelularni karcinom (PCC) je najčešće maligno oboljenje usne. Prema epidemiološkim podacima, u našoj populaciji skoro polovina (45%) PCC sluzokože usne duplje zahvata i donju i gornju usnu. Cilj ovog rada bio je utvrđivanje prognostičkog značaja histopatoloških karakteristika PCC usne: histološkog gradusa, nuklearnog gradusa i veličine tumora za pojavu recidiva bolesti i metastaza u regionalnim limfnim čvorovima. Metode. U retrospektivno-prospektivnoj studiji analizirano je 70 bolesnika sa PCC donje i gornje usne, dijagnostikovanim u periodu od 2002. do 2006. godine u Klinici za maksilofacijalnu hirurgiju Kliničkog centra Crne Gore. Podaci o lokalizaciji neoplazmi, životnom dobu i polu bolesnika, kao i o histopatološkim karakteristikama neoplazmi uzeti su iz uputnika za histopatološki pregled. Tokom tri godine, na redovnim postoperativnim kliničkim kontrolama, registrovana je eventualna pojava recidiva i/ili metastatske bolesti. Rezultati. Veličina tumora se statistički značajno razlikovala između ispitanika sa i bez recidiva bolesti (p = 0,027). Logističkom regresionom analizom utvrđeno je da je veličina tumora bila statistički značajan faktor (p = 0,011, R = 0,186) za pojavu metastaza u regionalnim limfnim čvorovima. Relativni rizik [exp (B)] od pojave metastaze u regionalnim limfnim čvorovima u odnosu na veličinu tumora iznosio je 2,807. Zaključak. Histološki i nuklearni gradusi tumora nisu prognostički faktori pojave recidiva i metastatske bolesti PCC usne. Veličina tumora predstavlja prognostički faktor za pojavu recidiva i regionalnih metastaza PCC usne, tj. faktor koji omogućava podelu bolesnika sa karcinomom usne u grupu sa većim, odnosno manjim rizikom od pojave recidiva i/ili metastatske bolesti. Prema našim rezultatima, sa povećanjem veličine PCC usne iznad 2 cm rizik od pojave regionalnih metastaza povećava se 2,8 puta.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma, Povezanost histopatoloških karakteristika karcinoma usne sa progresijom bolesti",
volume = "67",
number = "1",
pages = "19-24",
doi = "10.2298/VSP1001019G"
}

Golubović, M., Ašanin, B., Jelovac, D., Petrović, M.,& Antunović, M.. (2010). Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 67(1), 19-24.
https://doi.org/10.2298/VSP1001019G

Golubović M, Ašanin B, Jelovac D, Petrović M, Antunović M. Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma. in Vojnosanitetski pregled. 2010;67(1):19-24.
doi:10.2298/VSP1001019G .

Golubović, Mileta, Ašanin, Bogdan, Jelovac, Drago, Petrović, Milan, Antunović, Marija, "Correlation between disease progression and histopathologic criterions of the lip squamous cell carcinoma" in Vojnosanitetski pregled, 67, no. 1 (2010):19-24,
https://doi.org/10.2298/VSP1001019G . .

TY  - THES
AU  - Jelovac, Drago
PY  - 2009
UR  - https://plus.sr.cobiss.net/opac7/bib/1024166286
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/492
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Analiza p53 gena u histološki negativnim marginama skvamocelularnih karcinoma usne duplje
UR  - https://hdl.handle.net/21.15107/rcub_smile_492
ER  - 

@mastersthesis{
author = "Jelovac, Drago",
year = "2009",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Analiza p53 gena u histološki negativnim marginama skvamocelularnih karcinoma usne duplje",
url = "https://hdl.handle.net/21.15107/rcub_smile_492"
}

Jelovac, D.. (2009). Analiza p53 gena u histološki negativnim marginama skvamocelularnih karcinoma usne duplje. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_492

Jelovac D. Analiza p53 gena u histološki negativnim marginama skvamocelularnih karcinoma usne duplje. 2009;.
https://hdl.handle.net/21.15107/rcub_smile_492 .

Jelovac, Drago, "Analiza p53 gena u histološki negativnim marginama skvamocelularnih karcinoma usne duplje" (2009),
https://hdl.handle.net/21.15107/rcub_smile_492 .

TY  - JOUR
AU  - Popović, Branka
AU  - Jekić, Biljana
AU  - Jelovac, Drago
AU  - Novaković, Ivana
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1470
AB  - Introduction. p53 gene is the most common tumor suppressor gene involved in pathogenesis oral squamous cell carcinoma (OSCC). Protein product of p53 gene contributes to cell cycle control and apoptosis. p53 gene mutations may lead to uncontrolled cell growth. The aim of this study was to determine the incidence of mutation in DNA-binding domain of p53 gene. Materials and Methods. In the 60 specimens, the presence of point mutation in exons 5, 6, 7 and 8 was detected using PCR-SSCP method. To confirm the presence of p53 mutation found by SSCP method, five samples were analyzed by sequencing of exon 5. Results. Point mutation affecting exons 5, 6, 7 and 8 were found in 60% of analyzed samples. A higher incidence of mutation was detected in exon 7 and 8 (60%), than in exon 5 and 6. Sequencing of exon 5, confirmed the presence of mutations revealed by SSCP method. Study of associations showed an increase of p53 mutations in poor differentiated and carcinoma of higher clinical stages. Conclusion. p53 gene is one of major factor in control of cell cycle and has important role in pathogenesis of oral squamous cell carcinoma.
AB  - Uvod. TP53 je ključni tumor-supresorski gen uključen u patogenezu oralnih skvamocelularnih karcinoma (OSCK). Proteinski proizvod gena p53 zadužen je za kontrolu ćelijskog ciklusa i apoptozu, a mutacije u TP53 mogu dovesti do nekontrolisane proliferacije ćelija. Cilj ovog rada je bio da se utvrdi zastupljenost tačkastih mutacija u regionu gena p53 koji se vezuje za DNK, odnosno proceni uloga ovoga gena u patogenezi OSCK. Materijal i metode rada. U 60 uzoraka OSCK su korišćenjem metode lančane reakcije polimeraze i polimorfizma jednolančanih fragmenata DNK (PCR-SSCP) ispitane tačkaste mutacije u egzonima 5, 6, 7 i 8 gena p53. Pet slučajno odabranih uzoraka u kojima je otkrivena mutacija naknadno je podvrgnuto sekvenciranju radi potvrde validnosti metode PCR-SSCP. Rezultati. Tačkaste mutacije u nekom od analiziranih egzona gena p53 utvrđene su u 60% uzoraka OSCK. Veća učestalost mutacija zabeležena je u egzonima 7 i 8. Sekvenciranje je potvrdilo mutacije otkrivene metodom SSCP. Studija asocijacije pokazuje povećanje broja mutacija gena p53 kod slabo diferenciranih i karcinoma viših kliničkih stadijuma. Zaključak. Gen p53, jedan od glavnih kontrolora ćelijskog ciklusa, ima značajnu ulogu i u patogenezi karcinoma oralne duplje.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Mutation status of p53 gene in oral squamous cell carcinoma
T1  - Mutacioni status gena p53 u oralnim skvamocelularnim karcinomima
VL  - 56
IS  - 4
SP  - 171
EP  - 175
DO  - 10.2298/SGS0904171P
ER  - 

@article{
author = "Popović, Branka and Jekić, Biljana and Jelovac, Drago and Novaković, Ivana",
year = "2009",
abstract = "Introduction. p53 gene is the most common tumor suppressor gene involved in pathogenesis oral squamous cell carcinoma (OSCC). Protein product of p53 gene contributes to cell cycle control and apoptosis. p53 gene mutations may lead to uncontrolled cell growth. The aim of this study was to determine the incidence of mutation in DNA-binding domain of p53 gene. Materials and Methods. In the 60 specimens, the presence of point mutation in exons 5, 6, 7 and 8 was detected using PCR-SSCP method. To confirm the presence of p53 mutation found by SSCP method, five samples were analyzed by sequencing of exon 5. Results. Point mutation affecting exons 5, 6, 7 and 8 were found in 60% of analyzed samples. A higher incidence of mutation was detected in exon 7 and 8 (60%), than in exon 5 and 6. Sequencing of exon 5, confirmed the presence of mutations revealed by SSCP method. Study of associations showed an increase of p53 mutations in poor differentiated and carcinoma of higher clinical stages. Conclusion. p53 gene is one of major factor in control of cell cycle and has important role in pathogenesis of oral squamous cell carcinoma., Uvod. TP53 je ključni tumor-supresorski gen uključen u patogenezu oralnih skvamocelularnih karcinoma (OSCK). Proteinski proizvod gena p53 zadužen je za kontrolu ćelijskog ciklusa i apoptozu, a mutacije u TP53 mogu dovesti do nekontrolisane proliferacije ćelija. Cilj ovog rada je bio da se utvrdi zastupljenost tačkastih mutacija u regionu gena p53 koji se vezuje za DNK, odnosno proceni uloga ovoga gena u patogenezi OSCK. Materijal i metode rada. U 60 uzoraka OSCK su korišćenjem metode lančane reakcije polimeraze i polimorfizma jednolančanih fragmenata DNK (PCR-SSCP) ispitane tačkaste mutacije u egzonima 5, 6, 7 i 8 gena p53. Pet slučajno odabranih uzoraka u kojima je otkrivena mutacija naknadno je podvrgnuto sekvenciranju radi potvrde validnosti metode PCR-SSCP. Rezultati. Tačkaste mutacije u nekom od analiziranih egzona gena p53 utvrđene su u 60% uzoraka OSCK. Veća učestalost mutacija zabeležena je u egzonima 7 i 8. Sekvenciranje je potvrdilo mutacije otkrivene metodom SSCP. Studija asocijacije pokazuje povećanje broja mutacija gena p53 kod slabo diferenciranih i karcinoma viših kliničkih stadijuma. Zaključak. Gen p53, jedan od glavnih kontrolora ćelijskog ciklusa, ima značajnu ulogu i u patogenezi karcinoma oralne duplje.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Mutation status of p53 gene in oral squamous cell carcinoma, Mutacioni status gena p53 u oralnim skvamocelularnim karcinomima",
volume = "56",
number = "4",
pages = "171-175",
doi = "10.2298/SGS0904171P"
}

Popović, B., Jekić, B., Jelovac, D.,& Novaković, I.. (2009). Mutation status of p53 gene in oral squamous cell carcinoma. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 56(4), 171-175.
https://doi.org/10.2298/SGS0904171P

Popović B, Jekić B, Jelovac D, Novaković I. Mutation status of p53 gene in oral squamous cell carcinoma. in Stomatološki glasnik Srbije. 2009;56(4):171-175.
doi:10.2298/SGS0904171P .

Popović, Branka, Jekić, Biljana, Jelovac, Drago, Novaković, Ivana, "Mutation status of p53 gene in oral squamous cell carcinoma" in Stomatološki glasnik Srbije, 56, no. 4 (2009):171-175,
https://doi.org/10.2298/SGS0904171P . .