TY  - JOUR
AU  - Igić, Marija
AU  - Mihailović, Dragan
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Apostolović, Mirjana
AU  - Kostadinović, Ljiljana
AU  - Tricković-Janjić, Olivera
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1691
AB  - Gingival epithelial cells are the first physical barrier against periodontal pathogenic microorganisms. Bacterial products may penetrate the epithelium and directly disturb its integrity. We investigated the clinical and cytomorphological status of the gingiva in children with gingivitis before and after low-level laser therapy. The study enrolled 130 children divided into three groups: group 1 comprised 50 children with chronic catarrhal gingivitis who received basic treatment, group 2 comprised 50 children with chronic catarrhal gingivitis who received low-level laser treatment in addition to basic treatment, and group 3 comprised 30 children with healthy gingiva as controls. Oral hygiene and the status of the gingiva were assessed using the appropriate indexes before and after treatment. Inflammation of the gingiva was monitored by cytomorphometric evaluation. Cytomorphometric analysis revealed a statistically significant difference (p  lt  0.001) in the size of the nuclei of the stratified squamous epithelial cells of the gingiva before and after treatment in chronic catarrhal gingivitis. Evaluation using clinical parameters showed that treatment of gingivitis with basic treatment was successful. Cytomorphometric analysis showed that after basic treatment the nuclei of the stratified squamous epithelial cells of the gingiva were reduced in size, although not to the size found in healthy gingiva. However, after adjuvant low-level laser therapy, the size of the nuclei of the stratified squamous epithelial cells in the gingiva matched the size of the nuclei in the cells in healthy gingiva.
PB  - Springer London Ltd, London
T2  - Lasers in Medical Science
T1  - Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children
VL  - 27
IS  - 4
SP  - 843
EP  - 848
DO  - 10.1007/s10103-011-0993-z
ER  - 

@article{
author = "Igić, Marija and Mihailović, Dragan and Kesić, Ljiljana and Milašin, Jelena and Apostolović, Mirjana and Kostadinović, Ljiljana and Tricković-Janjić, Olivera",
year = "2012",
abstract = "Gingival epithelial cells are the first physical barrier against periodontal pathogenic microorganisms. Bacterial products may penetrate the epithelium and directly disturb its integrity. We investigated the clinical and cytomorphological status of the gingiva in children with gingivitis before and after low-level laser therapy. The study enrolled 130 children divided into three groups: group 1 comprised 50 children with chronic catarrhal gingivitis who received basic treatment, group 2 comprised 50 children with chronic catarrhal gingivitis who received low-level laser treatment in addition to basic treatment, and group 3 comprised 30 children with healthy gingiva as controls. Oral hygiene and the status of the gingiva were assessed using the appropriate indexes before and after treatment. Inflammation of the gingiva was monitored by cytomorphometric evaluation. Cytomorphometric analysis revealed a statistically significant difference (p  lt  0.001) in the size of the nuclei of the stratified squamous epithelial cells of the gingiva before and after treatment in chronic catarrhal gingivitis. Evaluation using clinical parameters showed that treatment of gingivitis with basic treatment was successful. Cytomorphometric analysis showed that after basic treatment the nuclei of the stratified squamous epithelial cells of the gingiva were reduced in size, although not to the size found in healthy gingiva. However, after adjuvant low-level laser therapy, the size of the nuclei of the stratified squamous epithelial cells in the gingiva matched the size of the nuclei in the cells in healthy gingiva.",
publisher = "Springer London Ltd, London",
journal = "Lasers in Medical Science",
title = "Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children",
volume = "27",
number = "4",
pages = "843-848",
doi = "10.1007/s10103-011-0993-z"
}

Igić, M., Mihailović, D., Kesić, L., Milašin, J., Apostolović, M., Kostadinović, L.,& Tricković-Janjić, O.. (2012). Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children. in Lasers in Medical Science
Springer London Ltd, London., 27(4), 843-848.
https://doi.org/10.1007/s10103-011-0993-z

Igić M, Mihailović D, Kesić L, Milašin J, Apostolović M, Kostadinović L, Tricković-Janjić O. Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children. in Lasers in Medical Science. 2012;27(4):843-848.
doi:10.1007/s10103-011-0993-z .

Igić, Marija, Mihailović, Dragan, Kesić, Ljiljana, Milašin, Jelena, Apostolović, Mirjana, Kostadinović, Ljiljana, Tricković-Janjić, Olivera, "Cytomorphometric and clinical investigation of the gingiva before and after low-level laser therapy of gingivitis in children" in Lasers in Medical Science, 27, no. 4 (2012):843-848,
https://doi.org/10.1007/s10103-011-0993-z . .

TY  - JOUR
AU  - Igić, Marija
AU  - Mihailović, Dragan
AU  - Kesić, Ljiljana
AU  - Apostolović, Mirjana
AU  - Kostadinović, Ljiljana
AU  - Tričković-Janjić, Olivera
AU  - Milašin, Jelena
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1647
AB  - Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect.
AB  - Uvod/Cilj. Gingivitis je česta pojava kod dece i može se smatrati faktorom rizika od nastanka i progresije oboljenja ostalih parodontalnih tkiva. Zato je potrebno blagovremeno i adekvatno reagovati kako ne bi došlo do progresije bolesti i nastanka parodontopatije. Cilj rada bio je da se utvrdi efikasnost primene hijaluronske kiseline u terapiji hroničnih gingivitisa kod dece. Metode. Ispitivanjem je bilo obuhvaćeno 130 dece sa stalnom denticijom. Svi ispitanici bili su podeljeni u tri grupe: grupa I - 50 ispitanika sa hroničnim gingivitisom kod kojih je primenjena samo bazična terapija; grupa II - 50 ispitanika sa hroničnim gingivitisom, kod kojih je uz bazičnu terapiju primenjena i terapija hijaluronskom kiselinom; grupa III - 30 ispitanika sa zdravom gingivom (kontrolna grupa). Procena stanja oralne higijene, stanja zdravlja gingive i parodoncijuma vršena je uz pomoć odgovarajućih indeksa pre i posle terapije. Inflamacija gingive praćena je citomorfometrijskim ispitivanjima. Rezultati. Pre terapije, vrednosti indeksa plaka (PI) bile su visoke: u grupi I 1,94, a u grupi II 1,68. Nakon terapije u obe grupe vrednosti PI iznosile su 0. U grupi III vrednost PI bila je 0,17. Indeks krvarenja (IKR) u grupi I pre terapije bio je 2,02, a posle terapije 0,32; u grupi II IKR pre terapije bio je 1,74, a posle terapije 0,16. U grupi III IKR bio je 0. U grupi I, pre terapije, Community Periodontal Index of Treatment Needs (CPITN) bio je 1,66, a posle terapije 0,32; u grupi II pre terapije CPITN bio je 1,5, a posle terapije 0,24. U grupi III CPITN indeks bio je 0. Kod ispitanika grupe I nakon terapije citomorfometrijskim ispitivanjem utvrđeno je da je došlo do smanjenja veličine jedara pločasto slojevitog epitela gingive, ali ne u tolikoj meri kao kod ispitanika grupe II. Zaključak. Bazičnom terapijom može se uspešno sanirati hronični gingivitis kod dece. Primena hijaluronske kiseline uz bazičnu terapiju može bitno poboljšati ovaj efekat.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children
T1  - Efikasnost hijaluronske kiseline u terapiji hroničnog gingivitisa kod dece
VL  - 68
IS  - 12
SP  - 1021
EP  - 1025
DO  - 10.2298/VSP1112021I
ER  - 

@article{
author = "Igić, Marija and Mihailović, Dragan and Kesić, Ljiljana and Apostolović, Mirjana and Kostadinović, Ljiljana and Tričković-Janjić, Olivera and Milašin, Jelena",
year = "2011",
abstract = "Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect., Uvod/Cilj. Gingivitis je česta pojava kod dece i može se smatrati faktorom rizika od nastanka i progresije oboljenja ostalih parodontalnih tkiva. Zato je potrebno blagovremeno i adekvatno reagovati kako ne bi došlo do progresije bolesti i nastanka parodontopatije. Cilj rada bio je da se utvrdi efikasnost primene hijaluronske kiseline u terapiji hroničnih gingivitisa kod dece. Metode. Ispitivanjem je bilo obuhvaćeno 130 dece sa stalnom denticijom. Svi ispitanici bili su podeljeni u tri grupe: grupa I - 50 ispitanika sa hroničnim gingivitisom kod kojih je primenjena samo bazična terapija; grupa II - 50 ispitanika sa hroničnim gingivitisom, kod kojih je uz bazičnu terapiju primenjena i terapija hijaluronskom kiselinom; grupa III - 30 ispitanika sa zdravom gingivom (kontrolna grupa). Procena stanja oralne higijene, stanja zdravlja gingive i parodoncijuma vršena je uz pomoć odgovarajućih indeksa pre i posle terapije. Inflamacija gingive praćena je citomorfometrijskim ispitivanjima. Rezultati. Pre terapije, vrednosti indeksa plaka (PI) bile su visoke: u grupi I 1,94, a u grupi II 1,68. Nakon terapije u obe grupe vrednosti PI iznosile su 0. U grupi III vrednost PI bila je 0,17. Indeks krvarenja (IKR) u grupi I pre terapije bio je 2,02, a posle terapije 0,32; u grupi II IKR pre terapije bio je 1,74, a posle terapije 0,16. U grupi III IKR bio je 0. U grupi I, pre terapije, Community Periodontal Index of Treatment Needs (CPITN) bio je 1,66, a posle terapije 0,32; u grupi II pre terapije CPITN bio je 1,5, a posle terapije 0,24. U grupi III CPITN indeks bio je 0. Kod ispitanika grupe I nakon terapije citomorfometrijskim ispitivanjem utvrđeno je da je došlo do smanjenja veličine jedara pločasto slojevitog epitela gingive, ali ne u tolikoj meri kao kod ispitanika grupe II. Zaključak. Bazičnom terapijom može se uspešno sanirati hronični gingivitis kod dece. Primena hijaluronske kiseline uz bazičnu terapiju može bitno poboljšati ovaj efekat.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children, Efikasnost hijaluronske kiseline u terapiji hroničnog gingivitisa kod dece",
volume = "68",
number = "12",
pages = "1021-1025",
doi = "10.2298/VSP1112021I"
}

Igić, M., Mihailović, D., Kesić, L., Apostolović, M., Kostadinović, L., Tričković-Janjić, O.,& Milašin, J.. (2011). Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 68(12), 1021-1025.
https://doi.org/10.2298/VSP1112021I

Igić M, Mihailović D, Kesić L, Apostolović M, Kostadinović L, Tričković-Janjić O, Milašin J. Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. in Vojnosanitetski pregled. 2011;68(12):1021-1025.
doi:10.2298/VSP1112021I .

Igić, Marija, Mihailović, Dragan, Kesić, Ljiljana, Apostolović, Mirjana, Kostadinović, Ljiljana, Tričković-Janjić, Olivera, Milašin, Jelena, "Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children" in Vojnosanitetski pregled, 68, no. 12 (2011):1021-1025,
https://doi.org/10.2298/VSP1112021I . .

TY  - JOUR
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Igić, Marija
AU  - Obradović, Radmila
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1380
AB  - The periodontal disease is a chronic, degenerative disease which is localised on the gingiva, periodontal ligament, cementum and alveolar bone. The main etiological factor is oral biofilm with microorganisms. The search for the pathogens of periodontal diseases has been underway for more than 100 years, and continues up today. The currently recognized key Gram negative periodontopathogens include: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus.All bacteria in the periodontal pocket could damage periodontal tissues, and good knowledge of these as well as an adequate treatment could be helpful in treatment of this disease. A full understanding of the microbial factors, their pathogenicity as well as host factors are of the essential importance for pathogenesis of periodontal disease. In this way, it could be possible to treat the periodontal patients adequately.
AB  - Parodontopatija predstavlja hroničnu, destruktivnu bolest, koja zahvata čitav potporni aparat zuba (gingiva, cement, alveolarna kost i periodoncijum). Glavni etiološki faktor u nastanku ovog oboljenja je oralni biofilm sa mikroorganizmima. Poslednjih 100 godina istraživači ispituju sastav mikrobiološke flore parodontalnog džepa. Do danas ključni Gram negativni periodontopatogeni su: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus. Sve prisutne bakterije u parodontalnom džepu mogu oštetiti parodontalna tkiva, i dobro poznavanje mikroorganizama omogućava i adekvatan tretman parodontopatije. Potpuno poznavanje mikroroganizama, njihove patogenosti, kao i poznavanje odgovora domaćina su osnovni za razumevanje patogeneze parodontopatije. ovo bi omogućilo i lečenje pacijenata sa parodontopatijom na odgovarajući način.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Medicine & Biology
T1  - Microbial etiology of periodontal disease: Mini review
T1  - Mikrobiološka etiologija parodontopatije
VL  - 15
IS  - 1
SP  - 1
EP  - 6
UR  - https://hdl.handle.net/21.15107/rcub_smile_1380
ER  - 

@article{
author = "Kesić, Ljiljana and Milašin, Jelena and Igić, Marija and Obradović, Radmila",
year = "2008",
abstract = "The periodontal disease is a chronic, degenerative disease which is localised on the gingiva, periodontal ligament, cementum and alveolar bone. The main etiological factor is oral biofilm with microorganisms. The search for the pathogens of periodontal diseases has been underway for more than 100 years, and continues up today. The currently recognized key Gram negative periodontopathogens include: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus.All bacteria in the periodontal pocket could damage periodontal tissues, and good knowledge of these as well as an adequate treatment could be helpful in treatment of this disease. A full understanding of the microbial factors, their pathogenicity as well as host factors are of the essential importance for pathogenesis of periodontal disease. In this way, it could be possible to treat the periodontal patients adequately., Parodontopatija predstavlja hroničnu, destruktivnu bolest, koja zahvata čitav potporni aparat zuba (gingiva, cement, alveolarna kost i periodoncijum). Glavni etiološki faktor u nastanku ovog oboljenja je oralni biofilm sa mikroorganizmima. Poslednjih 100 godina istraživači ispituju sastav mikrobiološke flore parodontalnog džepa. Do danas ključni Gram negativni periodontopatogeni su: Porphyromonas gingivalis, Prevotella intermedia, Bacteroides forsythus, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Capnocytophaga species, Campylobacter rectus. Sve prisutne bakterije u parodontalnom džepu mogu oštetiti parodontalna tkiva, i dobro poznavanje mikroorganizama omogućava i adekvatan tretman parodontopatije. Potpuno poznavanje mikroroganizama, njihove patogenosti, kao i poznavanje odgovora domaćina su osnovni za razumevanje patogeneze parodontopatije. ovo bi omogućilo i lečenje pacijenata sa parodontopatijom na odgovarajući način.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Medicine & Biology",
title = "Microbial etiology of periodontal disease: Mini review, Mikrobiološka etiologija parodontopatije",
volume = "15",
number = "1",
pages = "1-6",
url = "https://hdl.handle.net/21.15107/rcub_smile_1380"
}

Kesić, L., Milašin, J., Igić, M.,& Obradović, R.. (2008). Microbial etiology of periodontal disease: Mini review. in Facta universitatis - series: Medicine & Biology
Univerzitet u Nišu, Niš., 15(1), 1-6.
https://hdl.handle.net/21.15107/rcub_smile_1380

Kesić L, Milašin J, Igić M, Obradović R. Microbial etiology of periodontal disease: Mini review. in Facta universitatis - series: Medicine & Biology. 2008;15(1):1-6.
https://hdl.handle.net/21.15107/rcub_smile_1380 .

Kesić, Ljiljana, Milašin, Jelena, Igić, Marija, Obradović, Radmila, "Microbial etiology of periodontal disease: Mini review" in Facta universitatis - series: Medicine & Biology, 15, no. 1 (2008):1-6,
https://hdl.handle.net/21.15107/rcub_smile_1380 .