TY  - JOUR
AU  - Đukić, Ljiljana
AU  - Roganović, Jelena
AU  - Brajović, Milan
AU  - Bokonjić, Dejan
AU  - Stojić, Dragica
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1961
AB  - ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity
VL  - 21
IS  - 5
SP  - 619
EP  - 625
DO  - 10.1111/odi.12325
ER  - 

@article{
author = "Đukić, Ljiljana and Roganović, Jelena and Brajović, Milan and Bokonjić, Dejan and Stojić, Dragica",
year = "2015",
abstract = "ObjectiveThe present cross-sectional study aimed to determine the effect of first-line anti-hypertensive drugs (enalapril, metoprolol, and combinations of enalapril with metoprolol and/or hydrochlorothiazide) on salivary gland function and salivary total antioxidant capacity (TAC) in hypertensive patients with/without diabetes mellitus (DM) type 2. Materials and MethodsSalivary gland function was measured as xerostomia (interview) and unstimulated whole saliva flow rate (UWSFR) in 447 subjects (387 hypertensive and 60 healthy). Salivary TAC was evaluated by spectrophotometric assay. ResultsEnalapril is not xerogenic, while metoprolol and drug combinations are. In the presence of DM type 2, all drugs, except metoprolol, had pronounced xerogenic effect. Binary logistic regression analysis found enalapril to be significantly associated with decreased risk of xerogenic effect development, while DM type 2 with increased risk. In the presence of enalapril in hypertensive patients with/without DM type 2 salivary TAC was similar to that in healthy subjects, while for metoprolol was reduced. ConclusionsEnalapril is not xerogenic but is antioxidant, which moderately reduces the risk of xerogenic effect development even in the presence of DM type 2. However, metoprolol and drug combinations exhibit xerogenic effect. In DM type 2, xerogenic effect of all drugs was pronounced except of metoprolol.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity",
volume = "21",
number = "5",
pages = "619-625",
doi = "10.1111/odi.12325"
}

Đukić, L., Roganović, J., Brajović, M., Bokonjić, D.,& Stojić, D.. (2015). The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity. in Oral Diseases
Wiley, Hoboken., 21(5), 619-625.
https://doi.org/10.1111/odi.12325

Đukić L, Roganović J, Brajović M, Bokonjić D, Stojić D. The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity. in Oral Diseases. 2015;21(5):619-625.
doi:10.1111/odi.12325 .

Đukić, Ljiljana, Roganović, Jelena, Brajović, Milan, Bokonjić, Dejan, Stojić, Dragica, "The effects of anti-hypertensives and type 2 diabetes on salivary flow and total antioxidant capacity" in Oral Diseases, 21, no. 5 (2015):619-625,
https://doi.org/10.1111/odi.12325 . .

TY  - JOUR
AU  - Erceg, Predrag
AU  - Despotović, Nebojša
AU  - Milošević, Dragoslav P.
AU  - Soldatović, Ivan
AU  - Zdravković, Sanja
AU  - Tomić, Snezana
AU  - Marković, Ivana
AU  - Mihajlović, Gordana
AU  - Brajović, Milan
AU  - Bojović, Ognjen
AU  - Potić, Bojana
AU  - Davidović, Mladen
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1849
AB  - Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL in elderly heart failure subjects have included mostly outpatients, and little is known about determinants of HRQOL in hospitalized elderly population, especially in Serbia. In this study, we tried to identify factors that influence HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Methods: The study population consisted of 136 patients aged 65 years or older hospitalized for chronic heart failure. HRQOL was assessed using the Minnesota Living with Heart Failure questionnaire. Predictors of HRQOL were identified by multiple linear regression analysis. Results: Univariate analysis showed that patients with lower income, a longer history of chronic heart failure, and longer length of hospital stay, as well as those receiving aldosterone antagonists and digoxin, taking multiple medications, in a higher NYHA class, and showing signs of depression and cognitive impairment had significantly worse HRQOL. Presence of depressive symptoms (P lt 0.001), higher NYHA class (P=0.021), lower income (P=0.029), and longer duration of heart failure (P=0.049) were independent predictors of poor HRQOL. Conclusion: Depressive symptoms, higher NYHA class, lower income, and longer duration of chronic heart failure are independent predictors of poor HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Further, there is an association between multiple medication usage and poor HRQOL, as well as a negative impact of cognitive impairment on HRQOL. Hence, measures should be implemented to identify such patients, especially those with depressive symptoms, and appropriate interventions undertaken in order to improve their HRQOL.
PB  - Dove Medical Press Ltd, Albany
T2  - Clinical Interventions in Aging
T1  - Health-related quality of life in elderly patients hospitalized with chronic heart failure
VL  - 8
SP  - 1539
EP  - 1546
DO  - 10.2147/CIA.S53305
ER  - 

@article{
author = "Erceg, Predrag and Despotović, Nebojša and Milošević, Dragoslav P. and Soldatović, Ivan and Zdravković, Sanja and Tomić, Snezana and Marković, Ivana and Mihajlović, Gordana and Brajović, Milan and Bojović, Ognjen and Potić, Bojana and Davidović, Mladen",
year = "2013",
abstract = "Background: Chronic heart failure is a very common condition in the elderly, characterized not only by high mortality rates, but also by a strong impact on health-related quality of life (HRQOL). Previous studies of HRQOL in elderly heart failure subjects have included mostly outpatients, and little is known about determinants of HRQOL in hospitalized elderly population, especially in Serbia. In this study, we tried to identify factors that influence HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Methods: The study population consisted of 136 patients aged 65 years or older hospitalized for chronic heart failure. HRQOL was assessed using the Minnesota Living with Heart Failure questionnaire. Predictors of HRQOL were identified by multiple linear regression analysis. Results: Univariate analysis showed that patients with lower income, a longer history of chronic heart failure, and longer length of hospital stay, as well as those receiving aldosterone antagonists and digoxin, taking multiple medications, in a higher NYHA class, and showing signs of depression and cognitive impairment had significantly worse HRQOL. Presence of depressive symptoms (P lt 0.001), higher NYHA class (P=0.021), lower income (P=0.029), and longer duration of heart failure (P=0.049) were independent predictors of poor HRQOL. Conclusion: Depressive symptoms, higher NYHA class, lower income, and longer duration of chronic heart failure are independent predictors of poor HRQOL in elderly patients hospitalized with chronic heart failure in Serbia. Further, there is an association between multiple medication usage and poor HRQOL, as well as a negative impact of cognitive impairment on HRQOL. Hence, measures should be implemented to identify such patients, especially those with depressive symptoms, and appropriate interventions undertaken in order to improve their HRQOL.",
publisher = "Dove Medical Press Ltd, Albany",
journal = "Clinical Interventions in Aging",
title = "Health-related quality of life in elderly patients hospitalized with chronic heart failure",
volume = "8",
pages = "1539-1546",
doi = "10.2147/CIA.S53305"
}

Erceg, P., Despotović, N., Milošević, D. P., Soldatović, I., Zdravković, S., Tomić, S., Marković, I., Mihajlović, G., Brajović, M., Bojović, O., Potić, B.,& Davidović, M.. (2013). Health-related quality of life in elderly patients hospitalized with chronic heart failure. in Clinical Interventions in Aging
Dove Medical Press Ltd, Albany., 8, 1539-1546.
https://doi.org/10.2147/CIA.S53305

Erceg P, Despotović N, Milošević DP, Soldatović I, Zdravković S, Tomić S, Marković I, Mihajlović G, Brajović M, Bojović O, Potić B, Davidović M. Health-related quality of life in elderly patients hospitalized with chronic heart failure. in Clinical Interventions in Aging. 2013;8:1539-1546.
doi:10.2147/CIA.S53305 .

Erceg, Predrag, Despotović, Nebojša, Milošević, Dragoslav P., Soldatović, Ivan, Zdravković, Sanja, Tomić, Snezana, Marković, Ivana, Mihajlović, Gordana, Brajović, Milan, Bojović, Ognjen, Potić, Bojana, Davidović, Mladen, "Health-related quality of life in elderly patients hospitalized with chronic heart failure" in Clinical Interventions in Aging, 8 (2013):1539-1546,
https://doi.org/10.2147/CIA.S53305 . .