TY  - JOUR
AU  - De Marco, Patrizia
AU  - Zara, Susi
AU  - De Colli, Marianna
AU  - Radunović, Milena
AU  - Lazović, Vladimir
AU  - Ettorre, Valeria
AU  - Di Crescenzo, Antonello
AU  - Piattelli, Adriano
AU  - Cataldi, Amelia
AU  - Fontana, Antonella
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2218
AB  - Commercial collagen membranes are used in oral surgical procedures as scaffolds for bone deposition in guided bone regeneration. Here, we have enriched them with graphene oxide (GO) via a simple non-covalent functionalization, exploiting the capacity of oxygenated carbon functional moieties of GO to interact through hydrogen bonding with collagen. In the present paper, the GO-coated membranes have been characterized in terms of stability, nano-roughness, biocompatibility and induction of inflammatory response in human primary gingival fibroblast cells. The obtained coated membranes are demonstrated not to leak GO in the bulk solution, and to change some features of the membrane, such as stiffness and adhesion between the membrane and the atomic force microscopy (AFM) tip. Moreover, the presence of GO increases the roughness and the total surface exposed to the cells, as demonstrated by AFM analyses. The obtained material is biocompatible, and does not induce inflammation in the tested cells.
PB  - Iop Publishing Ltd, Bristol
T2  - Biomedical Materials
T1  - Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts
VL  - 12
IS  - 5
DO  - 10.1088/1748-605X/aa7907
ER  - 

@article{
author = "De Marco, Patrizia and Zara, Susi and De Colli, Marianna and Radunović, Milena and Lazović, Vladimir and Ettorre, Valeria and Di Crescenzo, Antonello and Piattelli, Adriano and Cataldi, Amelia and Fontana, Antonella",
year = "2017",
abstract = "Commercial collagen membranes are used in oral surgical procedures as scaffolds for bone deposition in guided bone regeneration. Here, we have enriched them with graphene oxide (GO) via a simple non-covalent functionalization, exploiting the capacity of oxygenated carbon functional moieties of GO to interact through hydrogen bonding with collagen. In the present paper, the GO-coated membranes have been characterized in terms of stability, nano-roughness, biocompatibility and induction of inflammatory response in human primary gingival fibroblast cells. The obtained coated membranes are demonstrated not to leak GO in the bulk solution, and to change some features of the membrane, such as stiffness and adhesion between the membrane and the atomic force microscopy (AFM) tip. Moreover, the presence of GO increases the roughness and the total surface exposed to the cells, as demonstrated by AFM analyses. The obtained material is biocompatible, and does not induce inflammation in the tested cells.",
publisher = "Iop Publishing Ltd, Bristol",
journal = "Biomedical Materials",
title = "Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts",
volume = "12",
number = "5",
doi = "10.1088/1748-605X/aa7907"
}

De Marco, P., Zara, S., De Colli, M., Radunović, M., Lazović, V., Ettorre, V., Di Crescenzo, A., Piattelli, A., Cataldi, A.,& Fontana, A.. (2017). Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts. in Biomedical Materials
Iop Publishing Ltd, Bristol., 12(5).
https://doi.org/10.1088/1748-605X/aa7907

De Marco P, Zara S, De Colli M, Radunović M, Lazović V, Ettorre V, Di Crescenzo A, Piattelli A, Cataldi A, Fontana A. Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts. in Biomedical Materials. 2017;12(5).
doi:10.1088/1748-605X/aa7907 .

De Marco, Patrizia, Zara, Susi, De Colli, Marianna, Radunović, Milena, Lazović, Vladimir, Ettorre, Valeria, Di Crescenzo, Antonello, Piattelli, Adriano, Cataldi, Amelia, Fontana, Antonella, "Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts" in Biomedical Materials, 12, no. 5 (2017),
https://doi.org/10.1088/1748-605X/aa7907 . .