TY  - JOUR
AU  - Perić, Tamara
AU  - Marković, Dejan
AU  - Petrović, Bojan
AU  - Radojević, Vesna J.
AU  - Todorović, Tatjana
AU  - Anđelski-Radičević, Biljana
AU  - Jančić-Heinemann, Radmila M.
AU  - Susić, Gordana
AU  - Peri'-Popadić, Aleksandra
AU  - Tomić-Spirić, Vesna
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1998
AB  - The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome
VL  - 19
IS  - 9
SP  - 2153
EP  - 2165
DO  - 10.1007/s00784-015-1444-1
ER  - 

@article{
author = "Perić, Tamara and Marković, Dejan and Petrović, Bojan and Radojević, Vesna J. and Todorović, Tatjana and Anđelski-Radičević, Biljana and Jančić-Heinemann, Radmila M. and Susić, Gordana and Peri'-Popadić, Aleksandra and Tomić-Spirić, Vesna",
year = "2015",
abstract = "The purpose of this study was to evaluate efficacy of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) containing pastes among individuals with Sjogren's syndrome (SS). Thirty patients were randomised into three groups: CPP-ACP, CPP-ACFP, and 0.05 % NaF to be used two times a day during a 28-day experimental period. Saliva was analysed for flow rate, pH, buffering capacity and mineral concentrations. Dental plaque was examined for pH. Following the formation of artificial carious lesion, participants wore enamel slabs for an in situ remineralisation study. Remineralisation potential was examined using scanning electron microscope (SEM) and energy dispersive spectroscopic (EDS) technique. SE microphotographs were subsequently analysed for area, diameter, perimeter, roundness and the number of enamel defects and percentage of tooth surface affected by defects. At the end of the experimental period, a slight increase of salivary pH could have been observed. No differences in mineral composition of saliva were noted. The use of CPP-ACP and CPP-ACFP contributed to a significant rise of plaque pH. Image analysis revealed excessive reduction of defects' dimensions in the three experimental groups, and a decrease of the number of enamel defects in the CPP-ACP and CPP-ACFP groups. The EDS analysis did not show differences in Ca/P, Ca/O and P/O ratios in any of the treatment groups. CPP-ACP and CPP-ACFP hold promise as remineralising agents for patients with SS. Pastes containing CPP-ACP/CPP-ACFP show enhanced remineralisation potential compared with NaF mouthrinse in patients with SS.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome",
volume = "19",
number = "9",
pages = "2153-2165",
doi = "10.1007/s00784-015-1444-1"
}

Perić, T., Marković, D., Petrović, B., Radojević, V. J., Todorović, T., Anđelski-Radičević, B., Jančić-Heinemann, R. M., Susić, G., Peri'-Popadić, A.,& Tomić-Spirić, V.. (2015). Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 19(9), 2153-2165.
https://doi.org/10.1007/s00784-015-1444-1

Perić T, Marković D, Petrović B, Radojević VJ, Todorović T, Anđelski-Radičević B, Jančić-Heinemann RM, Susić G, Peri'-Popadić A, Tomić-Spirić V. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome. in Clinical Oral Investigations. 2015;19(9):2153-2165.
doi:10.1007/s00784-015-1444-1 .

Perić, Tamara, Marković, Dejan, Petrović, Bojan, Radojević, Vesna J., Todorović, Tatjana, Anđelski-Radičević, Biljana, Jančić-Heinemann, Radmila M., Susić, Gordana, Peri'-Popadić, Aleksandra, Tomić-Spirić, Vesna, "Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjogren's syndrome" in Clinical Oral Investigations, 19, no. 9 (2015):2153-2165,
https://doi.org/10.1007/s00784-015-1444-1 . .

TY  - JOUR
AU  - Novaković, N.
AU  - Todorović, Tatjana
AU  - Rakić, Mia
AU  - Milinković, Iva
AU  - Dožić, Ivan
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Čakić, Saša
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1880
AB  - Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Periodontal Research
T1  - Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome
VL  - 49
IS  - 1
SP  - 129
EP  - 136
DO  - 10.1111/jre.12088
ER  - 

@article{
author = "Novaković, N. and Todorović, Tatjana and Rakić, Mia and Milinković, Iva and Dožić, Ivan and Janković, Saša and Aleksić, Zoran and Čakić, Saša",
year = "2014",
abstract = "Background and objective: One of the major pathologic patterns in periodontitis represents an imbalance among the production of free radicals and local antioxidants resulting in periodontal tissue destruction. The objective of the study was to investigate the influence of non-surgical periodontal treatment on salivary antioxidants and to evaluate their capacity as biomarkers reflecting periodontal tissue condition and therapy outcome. Material and Methods: Sixty-three systemically healthy non-smokers, including 21 periodontally healthy subjects (HC) and 42 patients with current chronic periodontitis fulfilled the inclusion criteria. Half of the patients received scaling and root planing (SRP) and the other half received only oral hygiene instructions. Full mouth clinical measurements, including gingival index (GI), plaque index (PI), periodontal pocket depth, clinical attachment level and saliva sampling were performed at baseline visit and 2 mo after treatment/baseline visit. Total antioxidant capacity (TAOC), albumins (ALB), uric acid (UA), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were evaluated in saliva samples using commercial kits. Results: All measured antioxidants were affected by treatment resulting in significant increase in TAOC (p  lt  0.005), ALB (p  lt  0.001), UA (p  lt  0.001) and GPX (p  lt  0.001) and decrease of SOD (p  lt  0.005) in response to SRP, where no differences were observed for any of parameters in the oral hygiene instructions group. Comparison of antioxidant levels between the HC and SRP group showed that before treatment ALB were significantly higher in HC when compared to the SRP group (p = 0.039), and GXP (p = 0.000) and SOD (p = 0.021) levels were significantly higher in the SRP group. Comparison of values after treatment showed that TAOC was significantly higher in the HC than in the SRP group (p = 0.001), but UA was, inversely, significantly higher in the SRP group (p = 0.034). All clinical parameters except clinical attachment level were significantly decreased after SRP and significant correlations were observed between SOD and GI (p = 0.017), SOD and PI (p = 0.011), GPX and GI (p = 0.003) and GPX and PI (p = 0.008). Conclusion: Non-surgical periodontal treatment affected salivary TAOC, ALB, UA, SOD and GPX; moreover, these biochemical parameters convincingly reflected periodontal status and tissue response on treatment.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Periodontal Research",
title = "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome",
volume = "49",
number = "1",
pages = "129-136",
doi = "10.1111/jre.12088"
}

Novaković, N., Todorović, T., Rakić, M., Milinković, I., Dožić, I., Janković, S., Aleksić, Z.,& Čakić, S.. (2014). Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research
Wiley-Blackwell, Hoboken., 49(1), 129-136.
https://doi.org/10.1111/jre.12088

Novaković N, Todorović T, Rakić M, Milinković I, Dožić I, Janković S, Aleksić Z, Čakić S. Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome. in Journal of Periodontal Research. 2014;49(1):129-136.
doi:10.1111/jre.12088 .

Novaković, N., Todorović, Tatjana, Rakić, Mia, Milinković, Iva, Dožić, Ivan, Janković, Saša, Aleksić, Zoran, Čakić, Saša, "Salivary antioxidants as periodontal biomarkers in evaluation of tissue status and treatment outcome" in Journal of Periodontal Research, 49, no. 1 (2014):129-136,
https://doi.org/10.1111/jre.12088 . .

TY  - JOUR
AU  - Ilić, Dragan
AU  - Obradović-Đuričić, Kosovka
AU  - Antonijević, Đorđe
AU  - Todorović, Tatjana
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1898
AB  - Introduction Antioxidants protect against reactive oxygen species and expose beneficial anti-inflammatory activity when in contact with biological tissues. Dental materials that are used as temporary luting on fixed dental restorations are often in contact with injured gingival tissue, hence they should contain anti-inflammatory characteristics that are essential after prosthetic procedures preceding cementation of final restauration. Objective The aim of this study was to investigate the antioxidant effect through the oxidation inhibition (OI) of mixed dental cement for temporary luting or their liquid component. Methods Eight study groups were prepared each by ten samples: 1) ex tempore preparation of zinc-oxide eugenol paste (Kariofil Z Galenika, Serbia), 2) Viko Temp paste (Galenika, Serbia), 3) Temp Bond NE paste (Kerr, Germany), 4) ScutaBond (ESPE, Germany), 5) Cp-CAP paste (Germany, Lege Artis) and oil component of 6) Kariofil Z, 7) Viko Temp and 8) Cp-CAP. The samples were subjected to spectrophotometer to measure OI 2,2'-azino-di-(3-ethyl-benzthiazoline-6-sulphonic acid) (ABTS) using Randox kit, United Kingdom. The control samples were pure ascorbic acid (1% w/v). Results High values of OI exposed materials (groups 1, 5, 6, 7, 8) with content of eugenol (or its derivates) in the range of 100-88.8% were statistically more significant than the values of non-eugenol substances (groups 2, 3, 4) with the range of 8.2-43.5%. Conclusion Eugenol containing temporary fixation materials show significant antioxidative properties and therefore they may be used in those clinical situations where surrounding gingival tissue is injured during restorative procedure.
AB  - Uvod Antioksidansi štite živa tkiva od reaktivnih kiseonikovih slobodnih radikala, čime ispoljavaju poželjno antiinflamatorno dejstvo u kontaktu sa živim tkivom. Stomatološki materijali koji služe za privremeno cementiranje protetičkih restauracija često su u kontaktu s lediranim tkivom gingive, pa stoga treba da poseduju poželjne antiinflamatorne osobine, vrlo bitne nakon protetičkih procedura koje prethode cementiranju fiksnih restauracija. Cilj rada Cilj ispitivanja je bio da se pomoću zabeleženih vrednosti inhibicije oksidacije (IO) utvrdi antioksidativni efekat nekoliko pripremljenih preparata za privremeno cementiranje i njihovih tečnih komponenata. Metode rada Po deset uzoraka je pripremljeno u osam eksperimentalnih grupa: 1) ex tempore zamešana cink-oksidna (ZnO) eugenol pasta (Kariofil Z Galenika, Srbija); 2) pasta Viko Temp (Galenika, Srbija); 3) pasta Temp Bond NE (Kerr, Nemačka); 4) pasta ScutaBond (ESPE, Nemačka); i 5) pasta Cp-CAP (Lege Artis, Nemačka); njihove tečne komponente: 6) ulje Kariofil Z; 7) ulje Viko Temp; i 8) ulje Cp-CAP. Uzorci su podvrgnuti spektrofotometru radi merenja vrednosti IO na ABTS primenom seta reagensa (Randox kit, Velika Britanija). Kontrolnu grupu su činili uzorci čiste askorbinske kiseline (1% w/v). Rezultati Visoke vrednosti IO ispoljili su uzorci u grupama eugenolnih materijala 1, 5, 6, 7 i 8 u rasponu od 88,8% do 100%, što je bilo statistički značajno u odnosu na niže vrednosti kod neeugenolnih materijala (raspon 8,2-43,5%) u grupama 2, 3 i 4. Zaključak Nije zabeležena statistička značajna razlika u vrednostima IO međusobnim poređenjem eugenolnih grupa (p>0,05). Poređenjem vrednosti IO između neeugenolnih grupa, samo je kod grupe 4 utvrđena statistički značajna razlika prema grupama 2 i 3 (p lt 0,01). Poređenjem uzoraka 2 i 3 zabeležena je statistički beznačajna razlika za vrednosti IO (p>0,05).
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Eugenol-based temporary luting cement possesses antioxidative properties
T1  - Privremeni cementi na bazi eugenola imaju antioksidativno dejstvo
VL  - 142
IS  - 11-12
SP  - 669
EP  - 674
DO  - 10.2298/SARH1412669I
ER  - 

@article{
author = "Ilić, Dragan and Obradović-Đuričić, Kosovka and Antonijević, Đorđe and Todorović, Tatjana",
year = "2014",
abstract = "Introduction Antioxidants protect against reactive oxygen species and expose beneficial anti-inflammatory activity when in contact with biological tissues. Dental materials that are used as temporary luting on fixed dental restorations are often in contact with injured gingival tissue, hence they should contain anti-inflammatory characteristics that are essential after prosthetic procedures preceding cementation of final restauration. Objective The aim of this study was to investigate the antioxidant effect through the oxidation inhibition (OI) of mixed dental cement for temporary luting or their liquid component. Methods Eight study groups were prepared each by ten samples: 1) ex tempore preparation of zinc-oxide eugenol paste (Kariofil Z Galenika, Serbia), 2) Viko Temp paste (Galenika, Serbia), 3) Temp Bond NE paste (Kerr, Germany), 4) ScutaBond (ESPE, Germany), 5) Cp-CAP paste (Germany, Lege Artis) and oil component of 6) Kariofil Z, 7) Viko Temp and 8) Cp-CAP. The samples were subjected to spectrophotometer to measure OI 2,2'-azino-di-(3-ethyl-benzthiazoline-6-sulphonic acid) (ABTS) using Randox kit, United Kingdom. The control samples were pure ascorbic acid (1% w/v). Results High values of OI exposed materials (groups 1, 5, 6, 7, 8) with content of eugenol (or its derivates) in the range of 100-88.8% were statistically more significant than the values of non-eugenol substances (groups 2, 3, 4) with the range of 8.2-43.5%. Conclusion Eugenol containing temporary fixation materials show significant antioxidative properties and therefore they may be used in those clinical situations where surrounding gingival tissue is injured during restorative procedure., Uvod Antioksidansi štite živa tkiva od reaktivnih kiseonikovih slobodnih radikala, čime ispoljavaju poželjno antiinflamatorno dejstvo u kontaktu sa živim tkivom. Stomatološki materijali koji služe za privremeno cementiranje protetičkih restauracija često su u kontaktu s lediranim tkivom gingive, pa stoga treba da poseduju poželjne antiinflamatorne osobine, vrlo bitne nakon protetičkih procedura koje prethode cementiranju fiksnih restauracija. Cilj rada Cilj ispitivanja je bio da se pomoću zabeleženih vrednosti inhibicije oksidacije (IO) utvrdi antioksidativni efekat nekoliko pripremljenih preparata za privremeno cementiranje i njihovih tečnih komponenata. Metode rada Po deset uzoraka je pripremljeno u osam eksperimentalnih grupa: 1) ex tempore zamešana cink-oksidna (ZnO) eugenol pasta (Kariofil Z Galenika, Srbija); 2) pasta Viko Temp (Galenika, Srbija); 3) pasta Temp Bond NE (Kerr, Nemačka); 4) pasta ScutaBond (ESPE, Nemačka); i 5) pasta Cp-CAP (Lege Artis, Nemačka); njihove tečne komponente: 6) ulje Kariofil Z; 7) ulje Viko Temp; i 8) ulje Cp-CAP. Uzorci su podvrgnuti spektrofotometru radi merenja vrednosti IO na ABTS primenom seta reagensa (Randox kit, Velika Britanija). Kontrolnu grupu su činili uzorci čiste askorbinske kiseline (1% w/v). Rezultati Visoke vrednosti IO ispoljili su uzorci u grupama eugenolnih materijala 1, 5, 6, 7 i 8 u rasponu od 88,8% do 100%, što je bilo statistički značajno u odnosu na niže vrednosti kod neeugenolnih materijala (raspon 8,2-43,5%) u grupama 2, 3 i 4. Zaključak Nije zabeležena statistička značajna razlika u vrednostima IO međusobnim poređenjem eugenolnih grupa (p>0,05). Poređenjem vrednosti IO između neeugenolnih grupa, samo je kod grupe 4 utvrđena statistički značajna razlika prema grupama 2 i 3 (p lt 0,01). Poređenjem uzoraka 2 i 3 zabeležena je statistički beznačajna razlika za vrednosti IO (p>0,05).",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Eugenol-based temporary luting cement possesses antioxidative properties, Privremeni cementi na bazi eugenola imaju antioksidativno dejstvo",
volume = "142",
number = "11-12",
pages = "669-674",
doi = "10.2298/SARH1412669I"
}

Ilić, D., Obradović-Đuričić, K., Antonijević, Đ.,& Todorović, T.. (2014). Eugenol-based temporary luting cement possesses antioxidative properties. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(11-12), 669-674.
https://doi.org/10.2298/SARH1412669I

Ilić D, Obradović-Đuričić K, Antonijević Đ, Todorović T. Eugenol-based temporary luting cement possesses antioxidative properties. in Srpski arhiv za celokupno lekarstvo. 2014;142(11-12):669-674.
doi:10.2298/SARH1412669I .

Ilić, Dragan, Obradović-Đuričić, Kosovka, Antonijević, Đorđe, Todorović, Tatjana, "Eugenol-based temporary luting cement possesses antioxidative properties" in Srpski arhiv za celokupno lekarstvo, 142, no. 11-12 (2014):669-674,
https://doi.org/10.2298/SARH1412669I . .

TY  - JOUR
AU  - Novaković, Nada
AU  - Čakić, Saša
AU  - Todorović, Tatjana
AU  - Anđelski-Radičević, Biljana
AU  - Dožić, Ivan
AU  - Petrović, Vanja
AU  - Perunović, Neda
AU  - Špadijer-Gostović, Aleksandra
AU  - Kadović-Sretenović, Jana
AU  - Čolak, Emina
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1796
AB  - Introduction. Oxidative stress and antioxidants play an important role in the pathogenesis of inflammatory disease, including chronic periodontitis (CP). Saliva contains enzymatic (glutathione peroxidase - GPx, superoxide dismutase - SOD, etc.) and non-enzymatic (albumin - ALB, uric acid - UA, glutathione, etc.) antioxidants. Objective. The aims of this study were to investigate: a) level of SOD, GPx, UA, ALB and total antioxidative status (TAS) of saliva in CP patients before and after non-surgical treatment, and b) correlations between clinical periodontal parameters and levels of salivary antioxidants. Methods. Saliva was collected from 21 CP patients before and after non-surgical treatment. The condition of periodontium was assessed by plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss. Level of investigated antioxidants (except GPx) and TAS was determined using colorimetric method and commercial kits. GPx activity was determined using UV method and commercial kits. Results. After the treatment significant increase of UA, ALB, Gpx, TAS was detected (p lt 0.01) and decrease of SOD activity (p>0.05). A significant correlation was observed between GPx and PI (r=0.575, p=0.008), SOD and GI (r=0.525, p=0.017) before therapy, and SOD and bleeding on probing (BP) (r=0.59, p=0.006), TAS and BP (r=0.453, p=0.045) after therapy. Conclusion. These data suggest that levels of salivary antioxidants generally increase after non-surgical periodontal treatment. Correlation between some clinical periodontal parameters and level of salivary antioxidants was found.
AB  - Uvod. Oksidativni stres i antioksidansi igraju važnu ulogu u patogenezi zapaljenjskih oboljenja, uključujući i hroničnu parodontopatiju. Pljuvačka sadrži enzimske antioksidanse, kao što su glutation-peroksidaza (GPx) i superoksid-dismutaza (SOD), i neenzimske antioksidanse, poput albumina (ALB), mokraćne kiseline (UA), glutationa itd. Cilj rada. Cilj istraživanja bio je da se ispitaju nivoi SOD, GPx, UA i ALB i utvrdi ukupan antioksidantni status pljuvačke (TAS) kod osoba s hroničnom parodontopatijom pre i posle kauzalne terapije, te ustanove korelacije između kliničkih pokazatelja stanja parodoncijuma i nivoa antioksidansa u pljuvački. Metode rada. Pljuvačka je sakupljena od 21 pacijenta s hroničnom parodontopatijom pre i posle kauzalne terapije. Stanje parodoncijuma je procenjivano pomoću: plak-indeksa (PI), gingivalnog indeksa (GI), indeksa krvarenja gingive (BP), dubine parodontalnog džepa i nivoa pripojnog epitela. Nivo ispitivanih antioksidansa (osim GPx) i TAS određivan je pomoću kolorimetrijske metode i komercijalnih reagensa. GPx je određivan primenom UV metode i komercijalnih reagensa. Rezultati. Nakon terapije ustanovljeni su značajno povećanje koncentracije UA, GPx i TAS (p lt 0,01) i smanjenje aktivnosti SOD (p>0,05). Primećena je i značajna korelacija između GPx i PI (r=0,575; p=0,008), te SOD i GI (r=0,525; p=0,017) pre terapije, odnosno SOD i BP (r=0,59; p=0,006), kao i TAS i BP (r=0,453; p=0,045) posle nje. Zaključak. Dobijeni nalazi pokazuju da se nivoi antioksidansa u pljuvački povećavaju nakon kauzalne terapije parodontopatije. Uočene su pozitivne korelacije između kliničkih pokazatelja stanja parodoncijuma i ispitivanih koncentracija antioksidansa u pljuvački.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Antioxidative status of saliva before and after non-surgical periodontal treatment
T1  - Antioksidantni status pljuvačke pre i posle kauzalne terapije parodontopatije
VL  - 141
IS  - 3-4
SP  - 163
EP  - 168
DO  - 10.2298/SARH1304163N
ER  - 

@article{
author = "Novaković, Nada and Čakić, Saša and Todorović, Tatjana and Anđelski-Radičević, Biljana and Dožić, Ivan and Petrović, Vanja and Perunović, Neda and Špadijer-Gostović, Aleksandra and Kadović-Sretenović, Jana and Čolak, Emina",
year = "2013",
abstract = "Introduction. Oxidative stress and antioxidants play an important role in the pathogenesis of inflammatory disease, including chronic periodontitis (CP). Saliva contains enzymatic (glutathione peroxidase - GPx, superoxide dismutase - SOD, etc.) and non-enzymatic (albumin - ALB, uric acid - UA, glutathione, etc.) antioxidants. Objective. The aims of this study were to investigate: a) level of SOD, GPx, UA, ALB and total antioxidative status (TAS) of saliva in CP patients before and after non-surgical treatment, and b) correlations between clinical periodontal parameters and levels of salivary antioxidants. Methods. Saliva was collected from 21 CP patients before and after non-surgical treatment. The condition of periodontium was assessed by plaque index, gingival index, bleeding on probing, probing depth and clinical attachment loss. Level of investigated antioxidants (except GPx) and TAS was determined using colorimetric method and commercial kits. GPx activity was determined using UV method and commercial kits. Results. After the treatment significant increase of UA, ALB, Gpx, TAS was detected (p lt 0.01) and decrease of SOD activity (p>0.05). A significant correlation was observed between GPx and PI (r=0.575, p=0.008), SOD and GI (r=0.525, p=0.017) before therapy, and SOD and bleeding on probing (BP) (r=0.59, p=0.006), TAS and BP (r=0.453, p=0.045) after therapy. Conclusion. These data suggest that levels of salivary antioxidants generally increase after non-surgical periodontal treatment. Correlation between some clinical periodontal parameters and level of salivary antioxidants was found., Uvod. Oksidativni stres i antioksidansi igraju važnu ulogu u patogenezi zapaljenjskih oboljenja, uključujući i hroničnu parodontopatiju. Pljuvačka sadrži enzimske antioksidanse, kao što su glutation-peroksidaza (GPx) i superoksid-dismutaza (SOD), i neenzimske antioksidanse, poput albumina (ALB), mokraćne kiseline (UA), glutationa itd. Cilj rada. Cilj istraživanja bio je da se ispitaju nivoi SOD, GPx, UA i ALB i utvrdi ukupan antioksidantni status pljuvačke (TAS) kod osoba s hroničnom parodontopatijom pre i posle kauzalne terapije, te ustanove korelacije između kliničkih pokazatelja stanja parodoncijuma i nivoa antioksidansa u pljuvački. Metode rada. Pljuvačka je sakupljena od 21 pacijenta s hroničnom parodontopatijom pre i posle kauzalne terapije. Stanje parodoncijuma je procenjivano pomoću: plak-indeksa (PI), gingivalnog indeksa (GI), indeksa krvarenja gingive (BP), dubine parodontalnog džepa i nivoa pripojnog epitela. Nivo ispitivanih antioksidansa (osim GPx) i TAS određivan je pomoću kolorimetrijske metode i komercijalnih reagensa. GPx je određivan primenom UV metode i komercijalnih reagensa. Rezultati. Nakon terapije ustanovljeni su značajno povećanje koncentracije UA, GPx i TAS (p lt 0,01) i smanjenje aktivnosti SOD (p>0,05). Primećena je i značajna korelacija između GPx i PI (r=0,575; p=0,008), te SOD i GI (r=0,525; p=0,017) pre terapije, odnosno SOD i BP (r=0,59; p=0,006), kao i TAS i BP (r=0,453; p=0,045) posle nje. Zaključak. Dobijeni nalazi pokazuju da se nivoi antioksidansa u pljuvački povećavaju nakon kauzalne terapije parodontopatije. Uočene su pozitivne korelacije između kliničkih pokazatelja stanja parodoncijuma i ispitivanih koncentracija antioksidansa u pljuvački.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Antioxidative status of saliva before and after non-surgical periodontal treatment, Antioksidantni status pljuvačke pre i posle kauzalne terapije parodontopatije",
volume = "141",
number = "3-4",
pages = "163-168",
doi = "10.2298/SARH1304163N"
}

Novaković, N., Čakić, S., Todorović, T., Anđelski-Radičević, B., Dožić, I., Petrović, V., Perunović, N., Špadijer-Gostović, A., Kadović-Sretenović, J.,& Čolak, E.. (2013). Antioxidative status of saliva before and after non-surgical periodontal treatment. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(3-4), 163-168.
https://doi.org/10.2298/SARH1304163N

Novaković N, Čakić S, Todorović T, Anđelski-Radičević B, Dožić I, Petrović V, Perunović N, Špadijer-Gostović A, Kadović-Sretenović J, Čolak E. Antioxidative status of saliva before and after non-surgical periodontal treatment. in Srpski arhiv za celokupno lekarstvo. 2013;141(3-4):163-168.
doi:10.2298/SARH1304163N .

Novaković, Nada, Čakić, Saša, Todorović, Tatjana, Anđelski-Radičević, Biljana, Dožić, Ivan, Petrović, Vanja, Perunović, Neda, Špadijer-Gostović, Aleksandra, Kadović-Sretenović, Jana, Čolak, Emina, "Antioxidative status of saliva before and after non-surgical periodontal treatment" in Srpski arhiv za celokupno lekarstvo, 141, no. 3-4 (2013):163-168,
https://doi.org/10.2298/SARH1304163N . .

TY  - JOUR
AU  - Anđelski-Radičević, Biljana
AU  - Dožić, Radica
AU  - Todorović, Tatjana
AU  - Dožić, Ivan
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1726
AB  - Diabetes mellitus is metabolic syndrome characterized by disorder in metabolism of carbon hydrates, lipids and proteins. The diagnosis of diabetes is established by measuring the blood glucose level using standardized methods. Frequent monitoring of blood glucose level could be inconvenient for patients because of possible pain during blood sample taking. In the last few years biological materials with non invasive sampling, like saliva, have been analyzed. Research has confirmed that some organic and inorganic components of saliva are modified in diabetic patients (glucose, lipid and protein components, oxidative stress markers, electrolytes). Beside other markers, the analysis of glucose in saliva is an attempt to find a non-invasive and painless way for frequent monitoring of glucose concentration in diabetic patients. Collecting saliva is simple and economical, it neither requires expensive equipment nor specially trained staff. Saliva can be taken many times and in unlimited quantity. In regards to the data about the possibilities for using saliva as biological sample in monitoring diabetes mellitus, which could be alternative to blood serum or plasma, the conclusion is that saliva becomes more important in this context.
AB  - Diabetes mellitus (DM) ili šećerna bolest je metabolički sindrom koji se odlikuje poremećajem metabolizma ugljenih hidrata, lipida i proteina. Dijagnoza dijabetesa postavlja se određivanjem koncentracije glukoze u krvnom serumu standardizovanim metodama. Često merenje nivoa šećera u krvi izaziva nelagodnost kod bolesnika tokom postupka venepunkcije. Poslednjih godi na sve više se analiziraju biološki materijali, kao što je pljuvačka, čiji je postupak prikupljanja neinvazivan. Na osnovu brojnih istraživanja dokazano je da dolazi do modifikacije organskih i neorganskih sastojaka pljuvačke (glukoza, lipidne i proteinske komponente, markeri oksidativnog stresa, elektroliti) kod osoba obolelih od DM. Pored ostalih markera, analiza glukoze u pljuvački je pokušaj da se pronađe neinvazivan i bezbolan način za često merenje glikemije kod ovih bolesnika. Prikupljanje pljuvačke jednostavno je za bolesnika, ne zahteva skupu opremu, niti posebno obučeno osoblje. Takođe, moguće je pljuvačku uzeti nekoliko puta i u neograničenim količinama. Na osnovu podataka o mogućnostima korišćenja pljuvačke kao biološkog uzorka u dijagnostikovanju DM, koji bi bio alternativa krvnom serumu, tj. plazmi, nameće se zaključak da ovaj sekret sve više dobija značaja u pomenutom kontekstu.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Biochemical markers in saliva of patients with diabetes mellitus
T1  - Biohemijski markeri u pljuvački osoba sa šećernom bolešću
VL  - 59
IS  - 4
SP  - 198
EP  - 204
DO  - 10.2298/SGS1204198A
ER  - 

@article{
author = "Anđelski-Radičević, Biljana and Dožić, Radica and Todorović, Tatjana and Dožić, Ivan",
year = "2012",
abstract = "Diabetes mellitus is metabolic syndrome characterized by disorder in metabolism of carbon hydrates, lipids and proteins. The diagnosis of diabetes is established by measuring the blood glucose level using standardized methods. Frequent monitoring of blood glucose level could be inconvenient for patients because of possible pain during blood sample taking. In the last few years biological materials with non invasive sampling, like saliva, have been analyzed. Research has confirmed that some organic and inorganic components of saliva are modified in diabetic patients (glucose, lipid and protein components, oxidative stress markers, electrolytes). Beside other markers, the analysis of glucose in saliva is an attempt to find a non-invasive and painless way for frequent monitoring of glucose concentration in diabetic patients. Collecting saliva is simple and economical, it neither requires expensive equipment nor specially trained staff. Saliva can be taken many times and in unlimited quantity. In regards to the data about the possibilities for using saliva as biological sample in monitoring diabetes mellitus, which could be alternative to blood serum or plasma, the conclusion is that saliva becomes more important in this context., Diabetes mellitus (DM) ili šećerna bolest je metabolički sindrom koji se odlikuje poremećajem metabolizma ugljenih hidrata, lipida i proteina. Dijagnoza dijabetesa postavlja se određivanjem koncentracije glukoze u krvnom serumu standardizovanim metodama. Često merenje nivoa šećera u krvi izaziva nelagodnost kod bolesnika tokom postupka venepunkcije. Poslednjih godi na sve više se analiziraju biološki materijali, kao što je pljuvačka, čiji je postupak prikupljanja neinvazivan. Na osnovu brojnih istraživanja dokazano je da dolazi do modifikacije organskih i neorganskih sastojaka pljuvačke (glukoza, lipidne i proteinske komponente, markeri oksidativnog stresa, elektroliti) kod osoba obolelih od DM. Pored ostalih markera, analiza glukoze u pljuvački je pokušaj da se pronađe neinvazivan i bezbolan način za često merenje glikemije kod ovih bolesnika. Prikupljanje pljuvačke jednostavno je za bolesnika, ne zahteva skupu opremu, niti posebno obučeno osoblje. Takođe, moguće je pljuvačku uzeti nekoliko puta i u neograničenim količinama. Na osnovu podataka o mogućnostima korišćenja pljuvačke kao biološkog uzorka u dijagnostikovanju DM, koji bi bio alternativa krvnom serumu, tj. plazmi, nameće se zaključak da ovaj sekret sve više dobija značaja u pomenutom kontekstu.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Biochemical markers in saliva of patients with diabetes mellitus, Biohemijski markeri u pljuvački osoba sa šećernom bolešću",
volume = "59",
number = "4",
pages = "198-204",
doi = "10.2298/SGS1204198A"
}

Anđelski-Radičević, B., Dožić, R., Todorović, T.,& Dožić, I.. (2012). Biochemical markers in saliva of patients with diabetes mellitus. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 59(4), 198-204.
https://doi.org/10.2298/SGS1204198A

Anđelski-Radičević B, Dožić R, Todorović T, Dožić I. Biochemical markers in saliva of patients with diabetes mellitus. in Stomatološki glasnik Srbije. 2012;59(4):198-204.
doi:10.2298/SGS1204198A .

Anđelski-Radičević, Biljana, Dožić, Radica, Todorović, Tatjana, Dožić, Ivan, "Biochemical markers in saliva of patients with diabetes mellitus" in Stomatološki glasnik Srbije, 59, no. 4 (2012):198-204,
https://doi.org/10.2298/SGS1204198A . .

TY  - JOUR
AU  - Dožić, Ivan
AU  - Todorović, Tatjana
AU  - Čolić, Miodrag
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1703
AB  - Introduction. Submandibular salivary gland is a part of the neuro-immune-endocrine system. It contains biological factors which regulate a number of functions in the body including the modulation of thymus function. Objective. The aim of the study was to investigate immunophenotypic characteristics of submandibular salivary glands of rats during ontogenesis, using the panels of monoclonal antibodies and to compare with the phenotypic characteristics of epithelial components of the thymus. Methods. Submandibular salivary glands and thymus were obtained from 1, 30 and 60 days old male AO (Albino, Oxford) rats. Streptavidin-biotin peroxidase method was used for staining. Results. Immunohistochemical analysis of rat submandibular salivary glands showed phenotypic heterogeneity of particular components of this gland during the postnatal development. We demonstrated that rat submandibular salivary glands share common antigens with rat thymic epithelial cells, but the observed phenotypic similarity between the individual regions was considered much more significant. Our data showed that the phenotypic similarity between duct epithelial cells and subcapsular epithelial cells and most medullary cells, whereas cortical epithelial cells are phenotypically similar to acinar cells. Conclusion. This immunohistological study showed phenotypic complexity of the submandibular salivary gland and similarity to the thymus that opens new perspectives in studying phenotypic similarities between this gland and lymphatic organs.
AB  - Uvod. Submandibularna pljuvačna žlezda je deo neuroimunoendokrinog sistema koja posredstvom bioloških faktora reguliše mnoge funkcije u organizmu, uključujući i modulaciju funkcije timusa. Cilj rada. Cilj rada bio je da se ispitaju imunofenotipske odlike submandibularne pljuvačne žlezde pacova tokom ontogeneze pomoću panela monoklonskih antitela i uporede s fenotipskim svojstvima epitelnih komponenti timusa. Metode rada. Istraživanja su rađena na pacovima soja AO (Albino Oxford), muškog pola, starosti od jednog, 30 i 60 dana. Za fenotipsku analizu korišćena je streptavidin-biotin- peroksidazna metoda bojenja. Rezultati. Ova imunohistološka studija ukazuje na heterogenost fenotipskih odlika pojedinih komponenti submandibularne pljuvačne žlezde tokom postnatalnog razvoja. Takođe je ustanovljeno da submandibularna pljuvačna žlezda i timus imaju zajedničke antigene, ali je mnogo značajnija fenotipska sličnost između pojedinih regiona u oba ispitivana organa. Epitelne ćelije izvodnih kanala submandibularne pljuvačne žlezde su fenotipski slične epitelnim ćelijama subkapsularne i većini ćelija u meduli timusa. Epitelne ćelije acinusa su fenotipski slične epitelnim ćelijama korteksa timusa. Zaključak. Fenotipska kompleksnost submandibularne pljuvačne žlezde i sličnost s timusom otvara nove mogućnosti za analizu fenotipske sličnosti između ove žlezde i limfatičnih organa.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Common immunophenotypic features of submandibular salivary glands and thymus in rats
T1  - Zajedničke imunofenotipske odlike podvilične pljuvačne žlezde i grudne žlezde pacova
VL  - 140
IS  - 5-6
SP  - 270
EP  - 277
DO  - 10.2298/SARH1206270D
ER  - 

@article{
author = "Dožić, Ivan and Todorović, Tatjana and Čolić, Miodrag",
year = "2012",
abstract = "Introduction. Submandibular salivary gland is a part of the neuro-immune-endocrine system. It contains biological factors which regulate a number of functions in the body including the modulation of thymus function. Objective. The aim of the study was to investigate immunophenotypic characteristics of submandibular salivary glands of rats during ontogenesis, using the panels of monoclonal antibodies and to compare with the phenotypic characteristics of epithelial components of the thymus. Methods. Submandibular salivary glands and thymus were obtained from 1, 30 and 60 days old male AO (Albino, Oxford) rats. Streptavidin-biotin peroxidase method was used for staining. Results. Immunohistochemical analysis of rat submandibular salivary glands showed phenotypic heterogeneity of particular components of this gland during the postnatal development. We demonstrated that rat submandibular salivary glands share common antigens with rat thymic epithelial cells, but the observed phenotypic similarity between the individual regions was considered much more significant. Our data showed that the phenotypic similarity between duct epithelial cells and subcapsular epithelial cells and most medullary cells, whereas cortical epithelial cells are phenotypically similar to acinar cells. Conclusion. This immunohistological study showed phenotypic complexity of the submandibular salivary gland and similarity to the thymus that opens new perspectives in studying phenotypic similarities between this gland and lymphatic organs., Uvod. Submandibularna pljuvačna žlezda je deo neuroimunoendokrinog sistema koja posredstvom bioloških faktora reguliše mnoge funkcije u organizmu, uključujući i modulaciju funkcije timusa. Cilj rada. Cilj rada bio je da se ispitaju imunofenotipske odlike submandibularne pljuvačne žlezde pacova tokom ontogeneze pomoću panela monoklonskih antitela i uporede s fenotipskim svojstvima epitelnih komponenti timusa. Metode rada. Istraživanja su rađena na pacovima soja AO (Albino Oxford), muškog pola, starosti od jednog, 30 i 60 dana. Za fenotipsku analizu korišćena je streptavidin-biotin- peroksidazna metoda bojenja. Rezultati. Ova imunohistološka studija ukazuje na heterogenost fenotipskih odlika pojedinih komponenti submandibularne pljuvačne žlezde tokom postnatalnog razvoja. Takođe je ustanovljeno da submandibularna pljuvačna žlezda i timus imaju zajedničke antigene, ali je mnogo značajnija fenotipska sličnost između pojedinih regiona u oba ispitivana organa. Epitelne ćelije izvodnih kanala submandibularne pljuvačne žlezde su fenotipski slične epitelnim ćelijama subkapsularne i većini ćelija u meduli timusa. Epitelne ćelije acinusa su fenotipski slične epitelnim ćelijama korteksa timusa. Zaključak. Fenotipska kompleksnost submandibularne pljuvačne žlezde i sličnost s timusom otvara nove mogućnosti za analizu fenotipske sličnosti između ove žlezde i limfatičnih organa.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Common immunophenotypic features of submandibular salivary glands and thymus in rats, Zajedničke imunofenotipske odlike podvilične pljuvačne žlezde i grudne žlezde pacova",
volume = "140",
number = "5-6",
pages = "270-277",
doi = "10.2298/SARH1206270D"
}

Dožić, I., Todorović, T.,& Čolić, M.. (2012). Common immunophenotypic features of submandibular salivary glands and thymus in rats. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(5-6), 270-277.
https://doi.org/10.2298/SARH1206270D

Dožić I, Todorović T, Čolić M. Common immunophenotypic features of submandibular salivary glands and thymus in rats. in Srpski arhiv za celokupno lekarstvo. 2012;140(5-6):270-277.
doi:10.2298/SARH1206270D .

Dožić, Ivan, Todorović, Tatjana, Čolić, Miodrag, "Common immunophenotypic features of submandibular salivary glands and thymus in rats" in Srpski arhiv za celokupno lekarstvo, 140, no. 5-6 (2012):270-277,
https://doi.org/10.2298/SARH1206270D . .

TY  - JOUR
AU  - Petković-Ćurčin, Aleksandra
AU  - Matić, Smiljana
AU  - Vojvodić, Danilo
AU  - Stamatović, Novak
AU  - Todorović, Tatjana
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1649
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Cytokines in pathogenesis of peri-implantitis
T1  - Uloga citokina u patogenezi periimplantitisa
VL  - 68
IS  - 5
SP  - 435
EP  - 440
DO  - 10.2298/VSP1105435P
ER  - 

@article{
author = "Petković-Ćurčin, Aleksandra and Matić, Smiljana and Vojvodić, Danilo and Stamatović, Novak and Todorović, Tatjana",
year = "2011",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Cytokines in pathogenesis of peri-implantitis, Uloga citokina u patogenezi periimplantitisa",
volume = "68",
number = "5",
pages = "435-440",
doi = "10.2298/VSP1105435P"
}

Petković-Ćurčin, A., Matić, S., Vojvodić, D., Stamatović, N.,& Todorović, T.. (2011). Cytokines in pathogenesis of peri-implantitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 68(5), 435-440.
https://doi.org/10.2298/VSP1105435P

Petković-Ćurčin A, Matić S, Vojvodić D, Stamatović N, Todorović T. Cytokines in pathogenesis of peri-implantitis. in Vojnosanitetski pregled. 2011;68(5):435-440.
doi:10.2298/VSP1105435P .

Petković-Ćurčin, Aleksandra, Matić, Smiljana, Vojvodić, Danilo, Stamatović, Novak, Todorović, Tatjana, "Cytokines in pathogenesis of peri-implantitis" in Vojnosanitetski pregled, 68, no. 5 (2011):435-440,
https://doi.org/10.2298/VSP1105435P . .

TY  - JOUR
AU  - Dožić, Ivan
AU  - Todorović, Tatjana
AU  - Dožić, Branko
AU  - Čolić, Miodrag
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1471
AB  - Cytokeratins (CK) are a group of proteins comprised of at least 20 different skeletal polypeptides specific for simple and complex epithelia of almost all tissues. Until recently only a few antibodies for cytoskeletal proteins were available and thus it was very difficult to visualize all the components of postnatal cytodifferentiation of salivary glands. Therefore, morphologic and immunophenotypic features of the CK polypeptides, have been analized within the rat submandibular salivary glands (SSG) during postnatal development. SSG were obtained from 1, 30 and 60 days old, male, AO rats. Streptavidin-biotin immunoperoxidase method was used for immunohistochemistry. Cryostat sections were fixed in acetone and incubated with monoclonal antibodies (mAbs) which specifically react with CK polypeptides (CK7, CK8, CK18, CK kidney, K8.12, K8.13) and rat epithelium (PT13D11). Immunohistochemical analysis of the rat SSG showed phenotypic heterogeneity of particular components of this gland during postnatal development. Regarding CK profiles it was shown that epithelial cells of the acini expressed CK18, whereas epithelial cells of the duct expressed K8.12 and K8.13 mAbs. Epithelial cells of the acini were not stained by K8.12 and PT13D11 mAbs. Intercalated ducts were strongly CK kidney+ and PT13D11+. Myoepithelial cells of the acini were stained by K8.13 mAbs, whereas these cells were not stained by mAbs specific for simple epithelia. This immunohistological study showed that the heterogeneity expression of CK polypeptides might also be useful to further understand the origin of epithelial SSG cells, as well as their development and function.
AB  - Citokeratini (CK) su grupa složenih proteina koji se sastoje od najmanje 20 različitih polipeptida citoskeleta, specifični za običan i složeni epitel skoro svih tkiva. Do skoro je bilo dostupno samo nekoliko antitela specifičnih za proteine citoskeleta i zbog toga je bila otežana vizualizacija komponenti postnatalne citodiferencijacije pljuvačnih žlezda. U ovoj studiji su, pomoću panela monoklonskih antitela (mAt), analizirane morfološke i imunofenotipske osobine CK polipeptida, u submandibularnoj pljuvač noj žlezdi (SPŽ) pacova tokom ontogeneze. Submandiblarne pljuvačne žlezde uzimane su od soja AO pacova, muškog pola, starosti 1, 30 i 60 dana. U ovom radu korišćena je imunohistohemijska metoda streptavidin-biotin peroksidaznog bojenja. Tkivni preseci fiksirani su u acetonu i inkubirani sa mAt specifičnim za CK polipeptide (CK7, CK 8, CK 18, CK bubrega, K8.12, K8.13) i epitel pacova (PT13D11). U ovoj imunohistohemijskoj analizi, ekspresija anti -CK antitela na SPŽ pacova, pokazuje fenotipsku heterogenost određenih komponenti ove žlezde tokom postnatalnog perioda. Epitelne ćelije acinusa su CK18+, dok epitelne ćelije kanalića imaju izražene CK definisane sa K8.12 i K8.13 mAt. Epitelne ćelije acinusa nisu bile obojene sa K8.12 i PT13D11 mAt. Umetnuti kanali su bili izrazito CK bubrega+ i PT13D11+. Mioepitelne ćelije acinusa su bile obojene sa K8.13 i PT13D11 mAt, dok su ove ćelije imale negativnu reakciju sa mAt specifičnim za obični epitel. Ova imunohistohemijska studija pokazuje heterogenost u ekspresiji CK polipeptida i može poslužiti za razumevanje porekla, razvoja i funkcije epitelnih ćelija SPŽ pacova.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Immunohistochemical identification of cytokeratins in the rat submandibular salivary glands during ontogenesis
T1  - Imunohistohemijska identifikacija citokeratina u submandibularnoj pljuvačnoj žlezdi pacova u toku ontogeneze
VL  - 59
IS  - 1
SP  - 69
EP  - 80
DO  - 10.2298/AVB0901069D
ER  - 

@article{
author = "Dožić, Ivan and Todorović, Tatjana and Dožić, Branko and Čolić, Miodrag",
year = "2009",
abstract = "Cytokeratins (CK) are a group of proteins comprised of at least 20 different skeletal polypeptides specific for simple and complex epithelia of almost all tissues. Until recently only a few antibodies for cytoskeletal proteins were available and thus it was very difficult to visualize all the components of postnatal cytodifferentiation of salivary glands. Therefore, morphologic and immunophenotypic features of the CK polypeptides, have been analized within the rat submandibular salivary glands (SSG) during postnatal development. SSG were obtained from 1, 30 and 60 days old, male, AO rats. Streptavidin-biotin immunoperoxidase method was used for immunohistochemistry. Cryostat sections were fixed in acetone and incubated with monoclonal antibodies (mAbs) which specifically react with CK polypeptides (CK7, CK8, CK18, CK kidney, K8.12, K8.13) and rat epithelium (PT13D11). Immunohistochemical analysis of the rat SSG showed phenotypic heterogeneity of particular components of this gland during postnatal development. Regarding CK profiles it was shown that epithelial cells of the acini expressed CK18, whereas epithelial cells of the duct expressed K8.12 and K8.13 mAbs. Epithelial cells of the acini were not stained by K8.12 and PT13D11 mAbs. Intercalated ducts were strongly CK kidney+ and PT13D11+. Myoepithelial cells of the acini were stained by K8.13 mAbs, whereas these cells were not stained by mAbs specific for simple epithelia. This immunohistological study showed that the heterogeneity expression of CK polypeptides might also be useful to further understand the origin of epithelial SSG cells, as well as their development and function., Citokeratini (CK) su grupa složenih proteina koji se sastoje od najmanje 20 različitih polipeptida citoskeleta, specifični za običan i složeni epitel skoro svih tkiva. Do skoro je bilo dostupno samo nekoliko antitela specifičnih za proteine citoskeleta i zbog toga je bila otežana vizualizacija komponenti postnatalne citodiferencijacije pljuvačnih žlezda. U ovoj studiji su, pomoću panela monoklonskih antitela (mAt), analizirane morfološke i imunofenotipske osobine CK polipeptida, u submandibularnoj pljuvač noj žlezdi (SPŽ) pacova tokom ontogeneze. Submandiblarne pljuvačne žlezde uzimane su od soja AO pacova, muškog pola, starosti 1, 30 i 60 dana. U ovom radu korišćena je imunohistohemijska metoda streptavidin-biotin peroksidaznog bojenja. Tkivni preseci fiksirani su u acetonu i inkubirani sa mAt specifičnim za CK polipeptide (CK7, CK 8, CK 18, CK bubrega, K8.12, K8.13) i epitel pacova (PT13D11). U ovoj imunohistohemijskoj analizi, ekspresija anti -CK antitela na SPŽ pacova, pokazuje fenotipsku heterogenost određenih komponenti ove žlezde tokom postnatalnog perioda. Epitelne ćelije acinusa su CK18+, dok epitelne ćelije kanalića imaju izražene CK definisane sa K8.12 i K8.13 mAt. Epitelne ćelije acinusa nisu bile obojene sa K8.12 i PT13D11 mAt. Umetnuti kanali su bili izrazito CK bubrega+ i PT13D11+. Mioepitelne ćelije acinusa su bile obojene sa K8.13 i PT13D11 mAt, dok su ove ćelije imale negativnu reakciju sa mAt specifičnim za obični epitel. Ova imunohistohemijska studija pokazuje heterogenost u ekspresiji CK polipeptida i može poslužiti za razumevanje porekla, razvoja i funkcije epitelnih ćelija SPŽ pacova.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Immunohistochemical identification of cytokeratins in the rat submandibular salivary glands during ontogenesis, Imunohistohemijska identifikacija citokeratina u submandibularnoj pljuvačnoj žlezdi pacova u toku ontogeneze",
volume = "59",
number = "1",
pages = "69-80",
doi = "10.2298/AVB0901069D"
}

Dožić, I., Todorović, T., Dožić, B.,& Čolić, M.. (2009). Immunohistochemical identification of cytokeratins in the rat submandibular salivary glands during ontogenesis. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(1), 69-80.
https://doi.org/10.2298/AVB0901069D

Dožić I, Todorović T, Dožić B, Čolić M. Immunohistochemical identification of cytokeratins in the rat submandibular salivary glands during ontogenesis. in Acta veterinaria. 2009;59(1):69-80.
doi:10.2298/AVB0901069D .

Dožić, Ivan, Todorović, Tatjana, Dožić, Branko, Čolić, Miodrag, "Immunohistochemical identification of cytokeratins in the rat submandibular salivary glands during ontogenesis" in Acta veterinaria, 59, no. 1 (2009):69-80,
https://doi.org/10.2298/AVB0901069D . .

TY  - JOUR
AU  - Anđelski-Radičević, Biljana
AU  - Zelić, Obrad
AU  - Mirković, Silvija
AU  - Todorović, Tatjana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1417
AB  - Background/Aim. Diabetes mellitus (DM) as a complex metabolic disease influences functioning of numerous organs. Therefore, frequent diabetic complication is chronic periodontitis. The aim of the study was to investigate the influence of various risk factors, like age, sex, duration of DM, oral hygiene, on oral manifestations of diabetes. Methods. The group of diabetics included 52 adult patients, 18-79-year of age, both sexes (33 females, 19 males) out of which 35 patients were with diabetes mellitus type I and 17 with type II. Mean age of the patients was 54.6 years and the mean duration of diabetes was 11.1 years. The controls consited of 67 volunteers from the city of Belgrade, 19-24-year of age, both sexes (47 females, 20 males) with no paradonthopathy and non-systemic diseases. Estimation of periodontal status of the patients was performed by measuring dental plaque index, gingival index and periodontal pockets' depth. Results. The results suggest an increased incidence and severity of periodontitis in diabetic patients. It was established that duration of diabetes, patients' age and bad oral hygiene had a negative influence on status of remained teeth in diabetics, while the sex had no influence on parameters monitored. Conclusion. Indices of oral hygiene level and periodontal status (dental plaque index, gingival index and periodontal pockets' depth) were significantly worsened in patients with diabetes. Negative influence on remained teeth had patients' age (>50 years), duration of diabetes (> 20 years) and bad oral hygiene. About half of the patients had a total or partial bridge suggesting that periodontitis is significant complication of diabetes mellitus.
AB  - Uvod/Cilj. Diabetes mellitus (DM) kao oboljenje u čijoj osnovi jeste metabolički poremećaj odražava se na funkcionisanje brojnih organa. Stoga, česte manifestacije dijabetesa predstavljaju i gingivitis i parodontopatija. Cilj rada bio je da se ispita uticaj različitih faktora (pol, starost, trajanje DM, higijena usta i zuba) na oralne manifestacije dijabetesa. Metode. Ispitana je grupa bolesnika obolelih od DM i kontrolna grupa zdravih osoba. Grupu ispitanika činila su 52 odrasla bolesnika, starosti 18-79 godina, oba pola (33 žene i 19 muškaraca), obolela od dijabetesa melitusa tip 1 (35 ispitanika) i tip 2 (17 ispitanika), lečena u Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Srednja starost ispitanika bila je 54,6 godina, a srednje trajanje dijabetesa 11,1 godina. Kontrolna grupa formirana je od 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta Univerziteta u Beogradu, starosti 19-24 godine, oba pola (47 ženskih i 20 muških), bez parodontopatije i sistemskih bolesti. Status periodoncijuma bolesnika definisan je na osnovu merenja indeksa plaka, gingivnog indeksa i dubine periodontnih džepova. Rezultati. Dobijeni rezultati ukazuju na povećanu učestalost i težinu parodontopatije kod bolesnika sa dijabetesom. Utvrđeno je da značajan negativni uticaj na stanje preostalih zuba kod bolesnika sa dijabetesom imaju dužina trajanja bolesti, starost bolesnika i loša oralna higijena, dok je pol bez uticaja na posmatrane promene. Zaključak. Pokazatelji nivoa oralne higijene i stanje periodontnog tkiva (indeks dentalnog plaka, gingivni indeks, dubina periodontnih džepova) značajno su pogoršani kod dijabetesnih bolesnika. Negativan uticaj na broj preostalih zuba imaju starost (> 50 godina), dužina trajanja dijabetesa (> 20 godina) i loša oralna higijena. Polovinu ispitanih bolesnika zbog gubitka svih ili velikog broja zuba nosi parcijalnu ili totalnu protezu, što pokazuje da je parodontopatija značajna komplikacija DM.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Periodontal condition in diabetics in Belgrade
T1  - Stanje tkiva periodoncijuma kod bolesnika sa dijabetesom melitusom u populaciji Beograda
VL  - 65
IS  - 11
SP  - 799
EP  - 802
DO  - 10.2298/VSP0811799A
ER  - 

@article{
author = "Anđelski-Radičević, Biljana and Zelić, Obrad and Mirković, Silvija and Todorović, Tatjana",
year = "2008",
abstract = "Background/Aim. Diabetes mellitus (DM) as a complex metabolic disease influences functioning of numerous organs. Therefore, frequent diabetic complication is chronic periodontitis. The aim of the study was to investigate the influence of various risk factors, like age, sex, duration of DM, oral hygiene, on oral manifestations of diabetes. Methods. The group of diabetics included 52 adult patients, 18-79-year of age, both sexes (33 females, 19 males) out of which 35 patients were with diabetes mellitus type I and 17 with type II. Mean age of the patients was 54.6 years and the mean duration of diabetes was 11.1 years. The controls consited of 67 volunteers from the city of Belgrade, 19-24-year of age, both sexes (47 females, 20 males) with no paradonthopathy and non-systemic diseases. Estimation of periodontal status of the patients was performed by measuring dental plaque index, gingival index and periodontal pockets' depth. Results. The results suggest an increased incidence and severity of periodontitis in diabetic patients. It was established that duration of diabetes, patients' age and bad oral hygiene had a negative influence on status of remained teeth in diabetics, while the sex had no influence on parameters monitored. Conclusion. Indices of oral hygiene level and periodontal status (dental plaque index, gingival index and periodontal pockets' depth) were significantly worsened in patients with diabetes. Negative influence on remained teeth had patients' age (>50 years), duration of diabetes (> 20 years) and bad oral hygiene. About half of the patients had a total or partial bridge suggesting that periodontitis is significant complication of diabetes mellitus., Uvod/Cilj. Diabetes mellitus (DM) kao oboljenje u čijoj osnovi jeste metabolički poremećaj odražava se na funkcionisanje brojnih organa. Stoga, česte manifestacije dijabetesa predstavljaju i gingivitis i parodontopatija. Cilj rada bio je da se ispita uticaj različitih faktora (pol, starost, trajanje DM, higijena usta i zuba) na oralne manifestacije dijabetesa. Metode. Ispitana je grupa bolesnika obolelih od DM i kontrolna grupa zdravih osoba. Grupu ispitanika činila su 52 odrasla bolesnika, starosti 18-79 godina, oba pola (33 žene i 19 muškaraca), obolela od dijabetesa melitusa tip 1 (35 ispitanika) i tip 2 (17 ispitanika), lečena u Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Srednja starost ispitanika bila je 54,6 godina, a srednje trajanje dijabetesa 11,1 godina. Kontrolna grupa formirana je od 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta Univerziteta u Beogradu, starosti 19-24 godine, oba pola (47 ženskih i 20 muških), bez parodontopatije i sistemskih bolesti. Status periodoncijuma bolesnika definisan je na osnovu merenja indeksa plaka, gingivnog indeksa i dubine periodontnih džepova. Rezultati. Dobijeni rezultati ukazuju na povećanu učestalost i težinu parodontopatije kod bolesnika sa dijabetesom. Utvrđeno je da značajan negativni uticaj na stanje preostalih zuba kod bolesnika sa dijabetesom imaju dužina trajanja bolesti, starost bolesnika i loša oralna higijena, dok je pol bez uticaja na posmatrane promene. Zaključak. Pokazatelji nivoa oralne higijene i stanje periodontnog tkiva (indeks dentalnog plaka, gingivni indeks, dubina periodontnih džepova) značajno su pogoršani kod dijabetesnih bolesnika. Negativan uticaj na broj preostalih zuba imaju starost (> 50 godina), dužina trajanja dijabetesa (> 20 godina) i loša oralna higijena. Polovinu ispitanih bolesnika zbog gubitka svih ili velikog broja zuba nosi parcijalnu ili totalnu protezu, što pokazuje da je parodontopatija značajna komplikacija DM.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Periodontal condition in diabetics in Belgrade, Stanje tkiva periodoncijuma kod bolesnika sa dijabetesom melitusom u populaciji Beograda",
volume = "65",
number = "11",
pages = "799-802",
doi = "10.2298/VSP0811799A"
}

Anđelski-Radičević, B., Zelić, O., Mirković, S.,& Todorović, T.. (2008). Periodontal condition in diabetics in Belgrade. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 65(11), 799-802.
https://doi.org/10.2298/VSP0811799A

Anđelski-Radičević B, Zelić O, Mirković S, Todorović T. Periodontal condition in diabetics in Belgrade. in Vojnosanitetski pregled. 2008;65(11):799-802.
doi:10.2298/VSP0811799A .

Anđelski-Radičević, Biljana, Zelić, Obrad, Mirković, Silvija, Todorović, Tatjana, "Periodontal condition in diabetics in Belgrade" in Vojnosanitetski pregled, 65, no. 11 (2008):799-802,
https://doi.org/10.2298/VSP0811799A . .

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Vujanović, Dragana
AU  - Dožić, Ivan
AU  - Petković-Ćurčin, Aleksandra
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1441
AB  - Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.
T2  - Magnesium Research
T1  - Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication
VL  - 21
IS  - 1
SP  - 43
EP  - 50
DO  - 10.1684/mrh.2008.0122
ER  - 

@article{
author = "Todorović, Tatjana and Vujanović, Dragana and Dožić, Ivan and Petković-Ćurčin, Aleksandra",
year = "2008",
abstract = "Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.",
journal = "Magnesium Research",
title = "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication",
volume = "21",
number = "1",
pages = "43-50",
doi = "10.1684/mrh.2008.0122"
}

Todorović, T., Vujanović, D., Dožić, I.,& Petković-Ćurčin, A.. (2008). Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research, 21(1), 43-50.
https://doi.org/10.1684/mrh.2008.0122

Todorović T, Vujanović D, Dožić I, Petković-Ćurčin A. Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research. 2008;21(1):43-50.
doi:10.1684/mrh.2008.0122 .

Todorović, Tatjana, Vujanović, Dragana, Dožić, Ivan, Petković-Ćurčin, Aleksandra, "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication" in Magnesium Research, 21, no. 1 (2008):43-50,
https://doi.org/10.1684/mrh.2008.0122 . .

TY  - JOUR
AU  - Anđelski-Radičević, Biljana
AU  - Mirković, Silvija
AU  - Todorović, Tatjana
AU  - Zelić, Obrad
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1283
AB  - Introduction: Diabetic patients, beside numerous acute and chronic complications, often have oral manifestations of the disease. Aim: The aim of the study was to establish changes in saliva of diabetic patients in relation to healthy population in order to use saliva in the disease monitoring, as well as the changes depending on the type of diabetes. Materials and methods: The study comprised 52 adult patients of both sexes and at the age between 18 and 79 with Diabetes mellitus type 1 and 2 who were treated at the Institute for endocrinology, diabetes and metabolic disorders of the Clinical center of Serbia. The control group consisted of 67 volunteers from Belgrade, students at the School of Dentistry, aged between 19 and 24. The whole of unstimulated and stimulated saliva was collected and biochemical parameters (glucose, total proteins, albumin, sodium and potassium) were determined by methods commonly used for serum. Results: The results showed that salivary potassium level was increased in saliva of diabetic patients, that of sodium and total proteins was decreased, and glucose and albumin did not show changes compared to the control group. Concentrations of total proteins and potassium were higher in patients with DM type 2, and sodium was higher in DM type 1 (p = 0.05). Conclusion: Diabetic patients often have changes in biochemical composition of saliva.
AB  - Uvod: Kod obolelih od Diabetes mellitus-a (DM), pored brojnih akutnih i hroničnih komplikacija, dolazi i do poremećaja oralne homeostaze. Cilj: Cilj rada bio je da se utvrde promene u biohemijskom sastavu salive dijabetesnih bolesnika u odnosu na zdravu populaciju radi eventualnog korišćenja salive u praćenju toka bolesti, odnosno da se utvrde promene u salivi u odnosu na tip dijabetesa. Materijal i metode: Istraživanje je obuhvatilo 52 odrasla pacijenta oba pola, uzrasta 18-79 godina, obolelih od DM - tip 1 i tip 2, lečenih na Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Kontrolnu grupu činilo je 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta u Beogradu, uzrasta 19-24 godine. Sakupljana je ukupna nestimulisana i stimulisana saliva, a biohemijski parametri (glukoza, ukupni proteini, albumin, natrijum i kalijum) određeni su referentnim metodama za serum. Rezultati: Dobijeni rezultati su pokazali da je u salivi obolelih od dijabetesa koncentracija kalijuma povišena, koncentracija natrijuma i ukupnih proteina snižena, a glukoze i albumina nepromenjena u odnosu na kontrolnu grupu. Koncentracije proteina i kalijuma više su kod obolelih od DM tip 2 nego kod DM tip 1, a koncentracija natrijuma viša je kod DM tip 1 (p = 0.05). Zaključak: Biohemijski sastav salive je ukazao na promene kod dijabetesnih bolesnika.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Changes in the biochemical composition of saliva in diabetic patients
T1  - Promene biohemijskog sastava salive kod dijabetičara
VL  - 53
IS  - 4
SP  - 209
EP  - 216
DO  - 10.2298/SGS0604209A
ER  - 

@article{
author = "Anđelski-Radičević, Biljana and Mirković, Silvija and Todorović, Tatjana and Zelić, Obrad",
year = "2006",
abstract = "Introduction: Diabetic patients, beside numerous acute and chronic complications, often have oral manifestations of the disease. Aim: The aim of the study was to establish changes in saliva of diabetic patients in relation to healthy population in order to use saliva in the disease monitoring, as well as the changes depending on the type of diabetes. Materials and methods: The study comprised 52 adult patients of both sexes and at the age between 18 and 79 with Diabetes mellitus type 1 and 2 who were treated at the Institute for endocrinology, diabetes and metabolic disorders of the Clinical center of Serbia. The control group consisted of 67 volunteers from Belgrade, students at the School of Dentistry, aged between 19 and 24. The whole of unstimulated and stimulated saliva was collected and biochemical parameters (glucose, total proteins, albumin, sodium and potassium) were determined by methods commonly used for serum. Results: The results showed that salivary potassium level was increased in saliva of diabetic patients, that of sodium and total proteins was decreased, and glucose and albumin did not show changes compared to the control group. Concentrations of total proteins and potassium were higher in patients with DM type 2, and sodium was higher in DM type 1 (p = 0.05). Conclusion: Diabetic patients often have changes in biochemical composition of saliva., Uvod: Kod obolelih od Diabetes mellitus-a (DM), pored brojnih akutnih i hroničnih komplikacija, dolazi i do poremećaja oralne homeostaze. Cilj: Cilj rada bio je da se utvrde promene u biohemijskom sastavu salive dijabetesnih bolesnika u odnosu na zdravu populaciju radi eventualnog korišćenja salive u praćenju toka bolesti, odnosno da se utvrde promene u salivi u odnosu na tip dijabetesa. Materijal i metode: Istraživanje je obuhvatilo 52 odrasla pacijenta oba pola, uzrasta 18-79 godina, obolelih od DM - tip 1 i tip 2, lečenih na Institutu za endokrinologiju, dijabetes i bolesti metabolizma Kliničkog centra Srbije. Kontrolnu grupu činilo je 67 dobrovoljaca iz Beograda, studenata Stomatološkog fakulteta u Beogradu, uzrasta 19-24 godine. Sakupljana je ukupna nestimulisana i stimulisana saliva, a biohemijski parametri (glukoza, ukupni proteini, albumin, natrijum i kalijum) određeni su referentnim metodama za serum. Rezultati: Dobijeni rezultati su pokazali da je u salivi obolelih od dijabetesa koncentracija kalijuma povišena, koncentracija natrijuma i ukupnih proteina snižena, a glukoze i albumina nepromenjena u odnosu na kontrolnu grupu. Koncentracije proteina i kalijuma više su kod obolelih od DM tip 2 nego kod DM tip 1, a koncentracija natrijuma viša je kod DM tip 1 (p = 0.05). Zaključak: Biohemijski sastav salive je ukazao na promene kod dijabetesnih bolesnika.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Changes in the biochemical composition of saliva in diabetic patients, Promene biohemijskog sastava salive kod dijabetičara",
volume = "53",
number = "4",
pages = "209-216",
doi = "10.2298/SGS0604209A"
}

Anđelski-Radičević, B., Mirković, S., Todorović, T.,& Zelić, O.. (2006). Changes in the biochemical composition of saliva in diabetic patients. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 53(4), 209-216.
https://doi.org/10.2298/SGS0604209A

Anđelski-Radičević B, Mirković S, Todorović T, Zelić O. Changes in the biochemical composition of saliva in diabetic patients. in Stomatološki glasnik Srbije. 2006;53(4):209-216.
doi:10.2298/SGS0604209A .

Anđelski-Radičević, Biljana, Mirković, Silvija, Todorović, Tatjana, Zelić, Obrad, "Changes in the biochemical composition of saliva in diabetic patients" in Stomatološki glasnik Srbije, 53, no. 4 (2006):209-216,
https://doi.org/10.2298/SGS0604209A . .

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Dožić, Ivan
AU  - Pavlica, Dušan
AU  - Marković, Dejan
AU  - Ivanović, Mirjana
AU  - Brajović, Gavrilo
AU  - Stefanović, Gordana
AU  - Mirković, Silvija
AU  - Anđelski, Biljana
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1233
AB  - Saliva is a secretion of the salivary and mucous glands and is of major importance in the maintainance of oral health. Over the last few decades, saliva has been evaluated as a diagnostic fluid in medicine for determining systemic disease markers as well as for monitoring numerous drugs, narcotics, and hormones. The biochemical analysis of saliva is particularly important in dentistry. The estimation of the risk of appearance and diagnosis of disease, monitoring of disease progression, evaluation of therapy efficacy for caries, periodontitis, premalignant and malignant oral lesions, as well as infectious diseases of the oral cavity, can be assessed by analyzing different constituent: of saliva, individuals at risk of caries can be identified using test: that determine saliva flow rate, saliva buffer capacity, and colonization of the oral cavity by cariogenic bacteria. Today, these rapid and simple diagnostic tests are used routinely in caries risk determination. The study and use of saliva-based diagnostics have increased over the last few decades. Clinical testing of saliva shows much promise. However, there is a need for much additional research in this area, before the true clinical value of saliva as a diagnostic fluid in dentistry can be determined.
AB  - Pljuvačka je sekret pljuvačnih i mukoznih žlezda koji je značajan za održavanje oralnog zdravlja. Poslednjih decenija sve više se razmatra mogućnost njene primene kao zamena krvi, odnosno krvnom serumu i plazme, radi dokazivanja pokazatelja sistemskih oboljenja, kao i za nadgledanje primene lekova, droga i hormona. Analiziranje biohemijskog sastava pljuvačke posebno je značajno u stomatologiji za procenu rizika nastanka, praćenja toka bolesti i kontrole rezultata primenjenog lečenja zubnog karijesa, parodontopatije, oralnih karcinoma i infektivnih oboljenja usne duplje. U proceni rizika nastanka karijesa na zubima rutinski se izvode ispitivanja kojima se određuju količina izlučene pljuvačke, njen puferski kapacitet i stepen kolonizacije usne duplje kariogenim vrstama bakterija. Jednostavnost izvođenja ovih ispitivanja omogućava da ih u stomatološkoj ordinaciji primenjuje lekar praktičar, što predstavlja veliku pomoć u proceni rizika za nastanak zubnog karijesa. Zbog bliskog kontakta s oralnim tkivima, pljuvačka sadrži brojne biohemijske pokazatelje patoloških procesa lokalizovanih u ovim tkivima (enzimi, imunoglobulini, ostali proteini, fenotipski pokazatelji). Ispitivanje pomenutih pokazatelja je značajno kao dopuna kliničkom dijagnostikovanju ukoliko ono ne pruža dovoljno informacija.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Use of saliva as a diagnostic fluid in dentistry
T1  - Mogućnosti upotrebe pljuvačke kao dijagnostičke tečnosti u stomatologiji
VL  - 133
IS  - 7-8
SP  - 372
EP  - 378
DO  - 10.2298/SARH0508372T
ER  - 

@article{
author = "Todorović, Tatjana and Dožić, Ivan and Pavlica, Dušan and Marković, Dejan and Ivanović, Mirjana and Brajović, Gavrilo and Stefanović, Gordana and Mirković, Silvija and Anđelski, Biljana",
year = "2005",
abstract = "Saliva is a secretion of the salivary and mucous glands and is of major importance in the maintainance of oral health. Over the last few decades, saliva has been evaluated as a diagnostic fluid in medicine for determining systemic disease markers as well as for monitoring numerous drugs, narcotics, and hormones. The biochemical analysis of saliva is particularly important in dentistry. The estimation of the risk of appearance and diagnosis of disease, monitoring of disease progression, evaluation of therapy efficacy for caries, periodontitis, premalignant and malignant oral lesions, as well as infectious diseases of the oral cavity, can be assessed by analyzing different constituent: of saliva, individuals at risk of caries can be identified using test: that determine saliva flow rate, saliva buffer capacity, and colonization of the oral cavity by cariogenic bacteria. Today, these rapid and simple diagnostic tests are used routinely in caries risk determination. The study and use of saliva-based diagnostics have increased over the last few decades. Clinical testing of saliva shows much promise. However, there is a need for much additional research in this area, before the true clinical value of saliva as a diagnostic fluid in dentistry can be determined., Pljuvačka je sekret pljuvačnih i mukoznih žlezda koji je značajan za održavanje oralnog zdravlja. Poslednjih decenija sve više se razmatra mogućnost njene primene kao zamena krvi, odnosno krvnom serumu i plazme, radi dokazivanja pokazatelja sistemskih oboljenja, kao i za nadgledanje primene lekova, droga i hormona. Analiziranje biohemijskog sastava pljuvačke posebno je značajno u stomatologiji za procenu rizika nastanka, praćenja toka bolesti i kontrole rezultata primenjenog lečenja zubnog karijesa, parodontopatije, oralnih karcinoma i infektivnih oboljenja usne duplje. U proceni rizika nastanka karijesa na zubima rutinski se izvode ispitivanja kojima se određuju količina izlučene pljuvačke, njen puferski kapacitet i stepen kolonizacije usne duplje kariogenim vrstama bakterija. Jednostavnost izvođenja ovih ispitivanja omogućava da ih u stomatološkoj ordinaciji primenjuje lekar praktičar, što predstavlja veliku pomoć u proceni rizika za nastanak zubnog karijesa. Zbog bliskog kontakta s oralnim tkivima, pljuvačka sadrži brojne biohemijske pokazatelje patoloških procesa lokalizovanih u ovim tkivima (enzimi, imunoglobulini, ostali proteini, fenotipski pokazatelji). Ispitivanje pomenutih pokazatelja je značajno kao dopuna kliničkom dijagnostikovanju ukoliko ono ne pruža dovoljno informacija.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Use of saliva as a diagnostic fluid in dentistry, Mogućnosti upotrebe pljuvačke kao dijagnostičke tečnosti u stomatologiji",
volume = "133",
number = "7-8",
pages = "372-378",
doi = "10.2298/SARH0508372T"
}

Todorović, T., Dožić, I., Pavlica, D., Marković, D., Ivanović, M., Brajović, G., Stefanović, G., Mirković, S.,& Anđelski, B.. (2005). Use of saliva as a diagnostic fluid in dentistry. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 133(7-8), 372-378.
https://doi.org/10.2298/SARH0508372T

Todorović T, Dožić I, Pavlica D, Marković D, Ivanović M, Brajović G, Stefanović G, Mirković S, Anđelski B. Use of saliva as a diagnostic fluid in dentistry. in Srpski arhiv za celokupno lekarstvo. 2005;133(7-8):372-378.
doi:10.2298/SARH0508372T .

Todorović, Tatjana, Dožić, Ivan, Pavlica, Dušan, Marković, Dejan, Ivanović, Mirjana, Brajović, Gavrilo, Stefanović, Gordana, Mirković, Silvija, Anđelski, Biljana, "Use of saliva as a diagnostic fluid in dentistry" in Srpski arhiv za celokupno lekarstvo, 133, no. 7-8 (2005):372-378,
https://doi.org/10.2298/SARH0508372T . .

TY  - JOUR
AU  - Dožić, Ivan
AU  - Todorović, Tatjana
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1256
AB  - Among the many functions of human saliva, its digestive and protective properties have attracted the most interest. Human saliva contains a number of physical, physicochemical and chemical agents that protect oral tissues against by various microorganisms and their metabolic products. Among such protective factors, the flushing effect of saliva flow is the most important one, not only because it so effectively removes exogenous and endogenous microorganisms and their products into the gut but also because a steady supply of saliva guarantees continuous presence of both non-immune and immune factors in the mouth. The most important antimicrobial peptides in saliva are: histatins, defensins, lactoferrin, cathelicidins, mucins, calprotectin, lysozyme, oral peroxidase. Antimicrobial peptides are components of complex host secretions, acting synergisticaly with other innate defence molecules to combat infection and control resident microbial populations throughout the oral cavity.
AB  - Pored uloge pljuvačke u samočišćenju oralne sredine, održavanju fizioloških vrednosti Ph, održavanju integriteta čvrstih i mekih tkiva oralne sredine, ovaj sekret ispoljava i značajnu antimikrobnu zaštitu oralnih tkiva. Pljuvačka sadrži brojne fizičke, fizičko-hemijske i hemijske agense koji učestvuju u zaštiti oralnih tkiva od mikroorganizama i njihovih produkata, s obzirom na činjenicu da usna duplja predstavlja „ulazna vrata“ organizma za patogene. Antimikrobni proteini pljuvačke predstavljaju glavne faktore nespecifične humoralne antimikrobne zaštite oralne sredine. Poreklom su iz pljuvačnih žlezda, epitelnih ćelija oralne mukoze i leukocita. Najznačajniji antimikrobni proteini pljuvačke su: histatini, defenzini, lakoferin, katelicidini, mucini, kalprotektin, lizozim, oralna peroksidaza. Pored toga što sprečavaju kolonizaciju oralne mukoze patogenim mikroorganizmima i održavanje normalne oralne bakterijske flore, ovi sastojci pljuvačke imaju i značaj u održavanju opšteg zdravlja organizma, jer sprečavaju transmisiju patogena u unutrašnju sredinu domaćina.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Antimicrobial peptides of human saliva
T1  - Antimikrobni proteini pljuvačke
VL  - 52
IS  - 4
SP  - 208
EP  - 216
DO  - 10.2298/SGS0504208D
ER  - 

@article{
author = "Dožić, Ivan and Todorović, Tatjana",
year = "2005",
abstract = "Among the many functions of human saliva, its digestive and protective properties have attracted the most interest. Human saliva contains a number of physical, physicochemical and chemical agents that protect oral tissues against by various microorganisms and their metabolic products. Among such protective factors, the flushing effect of saliva flow is the most important one, not only because it so effectively removes exogenous and endogenous microorganisms and their products into the gut but also because a steady supply of saliva guarantees continuous presence of both non-immune and immune factors in the mouth. The most important antimicrobial peptides in saliva are: histatins, defensins, lactoferrin, cathelicidins, mucins, calprotectin, lysozyme, oral peroxidase. Antimicrobial peptides are components of complex host secretions, acting synergisticaly with other innate defence molecules to combat infection and control resident microbial populations throughout the oral cavity., Pored uloge pljuvačke u samočišćenju oralne sredine, održavanju fizioloških vrednosti Ph, održavanju integriteta čvrstih i mekih tkiva oralne sredine, ovaj sekret ispoljava i značajnu antimikrobnu zaštitu oralnih tkiva. Pljuvačka sadrži brojne fizičke, fizičko-hemijske i hemijske agense koji učestvuju u zaštiti oralnih tkiva od mikroorganizama i njihovih produkata, s obzirom na činjenicu da usna duplja predstavlja „ulazna vrata“ organizma za patogene. Antimikrobni proteini pljuvačke predstavljaju glavne faktore nespecifične humoralne antimikrobne zaštite oralne sredine. Poreklom su iz pljuvačnih žlezda, epitelnih ćelija oralne mukoze i leukocita. Najznačajniji antimikrobni proteini pljuvačke su: histatini, defenzini, lakoferin, katelicidini, mucini, kalprotektin, lizozim, oralna peroksidaza. Pored toga što sprečavaju kolonizaciju oralne mukoze patogenim mikroorganizmima i održavanje normalne oralne bakterijske flore, ovi sastojci pljuvačke imaju i značaj u održavanju opšteg zdravlja organizma, jer sprečavaju transmisiju patogena u unutrašnju sredinu domaćina.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Antimicrobial peptides of human saliva, Antimikrobni proteini pljuvačke",
volume = "52",
number = "4",
pages = "208-216",
doi = "10.2298/SGS0504208D"
}

Dožić, I.,& Todorović, T.. (2005). Antimicrobial peptides of human saliva. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 52(4), 208-216.
https://doi.org/10.2298/SGS0504208D

Dožić I, Todorović T. Antimicrobial peptides of human saliva. in Stomatološki glasnik Srbije. 2005;52(4):208-216.
doi:10.2298/SGS0504208D .

Dožić, Ivan, Todorović, Tatjana, "Antimicrobial peptides of human saliva" in Stomatološki glasnik Srbije, 52, no. 4 (2005):208-216,
https://doi.org/10.2298/SGS0504208D . .

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Dožić, Ivan
AU  - Mandić, Bojan
AU  - Marjanović, Marjan
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1253
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Antioxidant role of saliva in maintaining oral health
T1  - Antioksidativna uloga pljuvačke u očuvanju zdravlja usta
VL  - 62
IS  - 7-8
SP  - 575
EP  - 579
DO  - 10.2298/VSP0508575T
ER  - 

@article{
author = "Todorović, Tatjana and Dožić, Ivan and Mandić, Bojan and Marjanović, Marjan",
year = "2005",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Antioxidant role of saliva in maintaining oral health, Antioksidativna uloga pljuvačke u očuvanju zdravlja usta",
volume = "62",
number = "7-8",
pages = "575-579",
doi = "10.2298/VSP0508575T"
}

Todorović, T., Dožić, I., Mandić, B.,& Marjanović, M.. (2005). Antioxidant role of saliva in maintaining oral health. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 62(7-8), 575-579.
https://doi.org/10.2298/VSP0508575T

Todorović T, Dožić I, Mandić B, Marjanović M. Antioxidant role of saliva in maintaining oral health. in Vojnosanitetski pregled. 2005;62(7-8):575-579.
doi:10.2298/VSP0508575T .

Todorović, Tatjana, Dožić, Ivan, Mandić, Bojan, Marjanović, Marjan, "Antioxidant role of saliva in maintaining oral health" in Vojnosanitetski pregled, 62, no. 7-8 (2005):575-579,
https://doi.org/10.2298/VSP0508575T . .

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Dožić, Ivan
AU  - Vujanović, Dragana
AU  - Pejović, J.
AU  - Marjanović, Marjan
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1240
AB  - In this paper, the influence of chronic lead intoxication on the activity of serum enzymes aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP) was examined. The experiment was performed on 130 adult female DA rats and 80 young rats. Rats were treated by lead-acetate 100 and 30 mg Pb per kg body weight for 10, 20, 30, 40, 50 and 60 days. Young rats (offspring of studied female rats) were treated with lead only through the placenta and mother's milk. The activities of serum AST, ALT and ALP were determined spectrophotomerically by IFCC method. The activity of examined serum enzymes was significantly increased in conditions of chronic lead intoxication in female rats and their offspring in relation to the control group. The activity of serum AST, ALT and ALP was in a positive correlation with the time of intoxication. There were no significant differences between the activities of enzymes AST and ALT in the serum and the amount of lead. The activity of ALP was significantly higher in serum of rats treated with higher amounts of lead. Increased AST, ALT and ALP activity in serum is most likely the consequence of lead hepatotoxicity.
AB  - U ovom radu su prikazani rezultati ispitivanja uticaja hroničnog trovanja olovom na aktivnost enzima aspartat i alanin aminotransferaze (AST i ALT) kao i alkalne fosfataze (ALP) u krvnom serumu pacova. Eksperiment je izveden na 130 ženki pacova i njihovih 80 mladunaca. Ženke su tretirane olovo-acetatom oralno putem pijaće vode u dve doze-100 i 30 mg/kg TM dnevno u trajanju od 10,20,30, 40, 50 i 60 dana, dok su njihovi mladunci olovo primali samo preko placente i putem mleka. Nakon žrtvovanja, od životinja je uzimana krv i u krvnom serumu je spektrofotometrijski, na automatskom analizatoru Hitachi 911, određivana aktivnost enzima AST, ALT i ALR Dobijeni rezultati su ukazali da hronično trovanje olovom ima za posledicu značajno povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki pacova, pri čemu se aktivnost navedenih enzima linearno povećavala sa povećanjem vremena intoksikacije. Nisu zapažene značajne razlike u aktivnosti enzima AST i ALT u odnosu na primenjenu dozu olova, dok je u slučaju ALP ustanovljeno da veća doza olova ima za posledicu značajnije povećanje aktivnosti ovog enzima u krvnom serumu. U mladunaca ženki koje su tokom trudnoće i laktacije primale olovo, takođe je ustanovljeno značajno povećanje aktivnosti navedenih enzima u krvnom serumu u odnosu na kontrolnu grupu. Nisu ustanovljene značajne razlike u aktivnosti AST, ALT i ALP u serumu mladunaca u pogledu doze olova koje su njihove majke primale. Povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki i mladunaca je najverovatnije posledica hepatotoksičnog dejstva olova udruženog sa intrahepatičkom holestazom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The influence of chronic lead poisoning on the activity of some serum enzymes in rats
T1  - Uticaj hroničnog trovanja olovom na aktivnost nekih enzima u krvnom serumu pacova
VL  - 55
IS  - 5-6
SP  - 471
EP  - 482
DO  - 10.2298/AVB0506471T
ER  - 

@article{
author = "Todorović, Tatjana and Dožić, Ivan and Vujanović, Dragana and Pejović, J. and Marjanović, Marjan",
year = "2005",
abstract = "In this paper, the influence of chronic lead intoxication on the activity of serum enzymes aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP) was examined. The experiment was performed on 130 adult female DA rats and 80 young rats. Rats were treated by lead-acetate 100 and 30 mg Pb per kg body weight for 10, 20, 30, 40, 50 and 60 days. Young rats (offspring of studied female rats) were treated with lead only through the placenta and mother's milk. The activities of serum AST, ALT and ALP were determined spectrophotomerically by IFCC method. The activity of examined serum enzymes was significantly increased in conditions of chronic lead intoxication in female rats and their offspring in relation to the control group. The activity of serum AST, ALT and ALP was in a positive correlation with the time of intoxication. There were no significant differences between the activities of enzymes AST and ALT in the serum and the amount of lead. The activity of ALP was significantly higher in serum of rats treated with higher amounts of lead. Increased AST, ALT and ALP activity in serum is most likely the consequence of lead hepatotoxicity., U ovom radu su prikazani rezultati ispitivanja uticaja hroničnog trovanja olovom na aktivnost enzima aspartat i alanin aminotransferaze (AST i ALT) kao i alkalne fosfataze (ALP) u krvnom serumu pacova. Eksperiment je izveden na 130 ženki pacova i njihovih 80 mladunaca. Ženke su tretirane olovo-acetatom oralno putem pijaće vode u dve doze-100 i 30 mg/kg TM dnevno u trajanju od 10,20,30, 40, 50 i 60 dana, dok su njihovi mladunci olovo primali samo preko placente i putem mleka. Nakon žrtvovanja, od životinja je uzimana krv i u krvnom serumu je spektrofotometrijski, na automatskom analizatoru Hitachi 911, određivana aktivnost enzima AST, ALT i ALR Dobijeni rezultati su ukazali da hronično trovanje olovom ima za posledicu značajno povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki pacova, pri čemu se aktivnost navedenih enzima linearno povećavala sa povećanjem vremena intoksikacije. Nisu zapažene značajne razlike u aktivnosti enzima AST i ALT u odnosu na primenjenu dozu olova, dok je u slučaju ALP ustanovljeno da veća doza olova ima za posledicu značajnije povećanje aktivnosti ovog enzima u krvnom serumu. U mladunaca ženki koje su tokom trudnoće i laktacije primale olovo, takođe je ustanovljeno značajno povećanje aktivnosti navedenih enzima u krvnom serumu u odnosu na kontrolnu grupu. Nisu ustanovljene značajne razlike u aktivnosti AST, ALT i ALP u serumu mladunaca u pogledu doze olova koje su njihove majke primale. Povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki i mladunaca je najverovatnije posledica hepatotoksičnog dejstva olova udruženog sa intrahepatičkom holestazom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The influence of chronic lead poisoning on the activity of some serum enzymes in rats, Uticaj hroničnog trovanja olovom na aktivnost nekih enzima u krvnom serumu pacova",
volume = "55",
number = "5-6",
pages = "471-482",
doi = "10.2298/AVB0506471T"
}

Todorović, T., Dožić, I., Vujanović, D., Pejović, J.,& Marjanović, M.. (2005). The influence of chronic lead poisoning on the activity of some serum enzymes in rats. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 55(5-6), 471-482.
https://doi.org/10.2298/AVB0506471T

Todorović T, Dožić I, Vujanović D, Pejović J, Marjanović M. The influence of chronic lead poisoning on the activity of some serum enzymes in rats. in Acta veterinaria. 2005;55(5-6):471-482.
doi:10.2298/AVB0506471T .

Todorović, Tatjana, Dožić, Ivan, Vujanović, Dragana, Pejović, J., Marjanović, Marjan, "The influence of chronic lead poisoning on the activity of some serum enzymes in rats" in Acta veterinaria, 55, no. 5-6 (2005):471-482,
https://doi.org/10.2298/AVB0506471T . .

TY  - THES
AU  - Todorović, Tatjana
PY  - 1998
UR  - https://plus.sr.cobiss.net/opac7/bib/18491407
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/340
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Ispitivanje uticaja hroničnog trovanja olovom na sadržaj minerala u tkivima pacova
UR  - https://hdl.handle.net/21.15107/rcub_smile_340
ER  - 

@phdthesis{
author = "Todorović, Tatjana",
year = "1998",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Ispitivanje uticaja hroničnog trovanja olovom na sadržaj minerala u tkivima pacova",
url = "https://hdl.handle.net/21.15107/rcub_smile_340"
}

Todorović, T.. (1998). Ispitivanje uticaja hroničnog trovanja olovom na sadržaj minerala u tkivima pacova. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_340

Todorović T. Ispitivanje uticaja hroničnog trovanja olovom na sadržaj minerala u tkivima pacova. 1998;.
https://hdl.handle.net/21.15107/rcub_smile_340 .

Todorović, Tatjana, "Ispitivanje uticaja hroničnog trovanja olovom na sadržaj minerala u tkivima pacova" (1998),
https://hdl.handle.net/21.15107/rcub_smile_340 .

TY  - THES
AU  - Todorović, Tatjana
PY  - 1992
UR  - https://plus.sr.cobiss.net/opac7/bib/1024060814
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/276
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Uloga salivarnih makroelektrolita kalcijuma, magnezijuma i fosfora u pojavi karijesa zuba u dece
UR  - https://hdl.handle.net/21.15107/rcub_smile_276
ER  - 

@mastersthesis{
author = "Todorović, Tatjana",
year = "1992",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Uloga salivarnih makroelektrolita kalcijuma, magnezijuma i fosfora u pojavi karijesa zuba u dece",
url = "https://hdl.handle.net/21.15107/rcub_smile_276"
}

Todorović, T.. (1992). Uloga salivarnih makroelektrolita kalcijuma, magnezijuma i fosfora u pojavi karijesa zuba u dece. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_276

Todorović T. Uloga salivarnih makroelektrolita kalcijuma, magnezijuma i fosfora u pojavi karijesa zuba u dece. 1992;.
https://hdl.handle.net/21.15107/rcub_smile_276 .

Todorović, Tatjana, "Uloga salivarnih makroelektrolita kalcijuma, magnezijuma i fosfora u pojavi karijesa zuba u dece" (1992),
https://hdl.handle.net/21.15107/rcub_smile_276 .