Koruga, Đuro

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  • Koruga, Đuro (3)
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Author's Bibliography

Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins

Lisul, Bogdan; Jelovac, Drago; Petrović, Milan; Tepavčević, Zvezdana; Koruga, Đuro; Grga, Đurica

(Springer Heidelberg, Heidelberg, 2019)

TY  - JOUR
AU  - Lisul, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Tepavčević, Zvezdana
AU  - Koruga, Đuro
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2424
AB  - PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical & Biological Engineering
T1  - Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins
VL  - 39
IS  - 6
SP  - 874
EP  - 884
DO  - 10.1007/s40846-019-00473-y
ER  - 
@article{
author = "Lisul, Bogdan and Jelovac, Drago and Petrović, Milan and Tepavčević, Zvezdana and Koruga, Đuro and Grga, Đurica",
year = "2019",
abstract = "PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical & Biological Engineering",
title = "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins",
volume = "39",
number = "6",
pages = "874-884",
doi = "10.1007/s40846-019-00473-y"
}
Lisul, B., Jelovac, D., Petrović, M., Tepavčević, Z., Koruga, Đ.,& Grga, Đ.. (2019). Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering
Springer Heidelberg, Heidelberg., 39(6), 874-884.
https://doi.org/10.1007/s40846-019-00473-y
Lisul B, Jelovac D, Petrović M, Tepavčević Z, Koruga Đ, Grga Đ. Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering. 2019;39(6):874-884.
doi:10.1007/s40846-019-00473-y .
Lisul, Bogdan, Jelovac, Drago, Petrović, Milan, Tepavčević, Zvezdana, Koruga, Đuro, Grga, Đurica, "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins" in Journal of Medical & Biological Engineering, 39, no. 6 (2019):874-884,
https://doi.org/10.1007/s40846-019-00473-y . .
2
2

Dental calculus: Nanocharacterization

Grga, Đurica; Marjanović, Marina; Hut, Igor; Dželetović, Bojan; Koruga, Đuro

(Srpsko lekarsko društvo - Stomatološka sekcija, Beograd, 2012)

TY  - JOUR
AU  - Grga, Đurica
AU  - Marjanović, Marina
AU  - Hut, Igor
AU  - Dželetović, Bojan
AU  - Koruga, Đuro
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1721
AB  - Emerging technologies and new nanoscale information have potential to transform dental practice by improving all aspects of diagnostics and therapy. Nanocharacterization allows understanding of oral diseases at molecular and cellular levels which eventually can increase the success of prevention and treatment. Opto-magnetic spectroscopy (OMS) is a promising new technique based on light-matter interaction which allows insight into the quantum state of matter. Since biomolecules and tissues are usually paramagnetic or diamagnetic materials it is possible to determine the dynamics of para-and diamagnetism at different teeth structures using that method. The topography of the surface of a sample can be obtained with a very high resolution using atomic force microscopy (AFM), which allows observation of minimal changes up to 10 nm, while magnetic force microscopy (MFM) is used to record the magnetic field gradient and its distribution over the surface of a sample. The aim of this study was to determine the possibility of AFM and MFM for the characterization of dental calculus, and a potential application of OMS for the detection of subgingival dental calculus.
AB  - Inovativne tehnologije i nove informacije na nanonivou imaju potencijal da poboljšaju stomatološku praksu, unapređujući sve aspekte dijagnostike i terapije. Nanokarakterizacija omogućava razumevanje razvoja oboljenja na ćelijskom i molekularnom nivou, što za krajnji rezultat može imati poboljšanje prevencije i uspeha lečenja. Optomagnetna spektroskopija (engl. opto-magnetic spectroscopy - OMS) je nova tehnika koja obećava, a zasnovana je na interakciji svetlosti i materije koja omogućava uvid u kvantno stanje materije. S obzirom na to da biomolekuli i tkiva mogu ispoljavati osobine paramagnetičnosti, odnosno dijamagnetičnosti, ovom metodom moguće je utvrditi dinamiku paramagnetizma i dijamagnetizma na različitim strukturama zuba. Pomoću mikroskopije atomskih sila (engl. atomic force microscopy - AFM) moguće je dobiti topografiju površine uzorka vrlo visoke rezolucije, čime se uočavaju i najmanje promene sve do 10 nm, dok se mikroskopija magnetnih sila (engl. magnetic force microscopy - MFM) koristi za snimanje gradijenta magnetnog polja i njegove raspodele po površini uzorka. Cilj ovog rada bio je da prikaže mogućnosti primene AFM i MFM za karakterizaciju zubnog kamenca, kao i primene OMS za otkrivanje subgingivalnog kalkulusa.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Dental calculus: Nanocharacterization
T1  - Zubni kamenac - karakterizacija na nanonivou
VL  - 59
IS  - 3
SP  - 154
EP  - 159
DO  - 10.2298/SGS1203154G
ER  - 
@article{
author = "Grga, Đurica and Marjanović, Marina and Hut, Igor and Dželetović, Bojan and Koruga, Đuro",
year = "2012",
abstract = "Emerging technologies and new nanoscale information have potential to transform dental practice by improving all aspects of diagnostics and therapy. Nanocharacterization allows understanding of oral diseases at molecular and cellular levels which eventually can increase the success of prevention and treatment. Opto-magnetic spectroscopy (OMS) is a promising new technique based on light-matter interaction which allows insight into the quantum state of matter. Since biomolecules and tissues are usually paramagnetic or diamagnetic materials it is possible to determine the dynamics of para-and diamagnetism at different teeth structures using that method. The topography of the surface of a sample can be obtained with a very high resolution using atomic force microscopy (AFM), which allows observation of minimal changes up to 10 nm, while magnetic force microscopy (MFM) is used to record the magnetic field gradient and its distribution over the surface of a sample. The aim of this study was to determine the possibility of AFM and MFM for the characterization of dental calculus, and a potential application of OMS for the detection of subgingival dental calculus., Inovativne tehnologije i nove informacije na nanonivou imaju potencijal da poboljšaju stomatološku praksu, unapređujući sve aspekte dijagnostike i terapije. Nanokarakterizacija omogućava razumevanje razvoja oboljenja na ćelijskom i molekularnom nivou, što za krajnji rezultat može imati poboljšanje prevencije i uspeha lečenja. Optomagnetna spektroskopija (engl. opto-magnetic spectroscopy - OMS) je nova tehnika koja obećava, a zasnovana je na interakciji svetlosti i materije koja omogućava uvid u kvantno stanje materije. S obzirom na to da biomolekuli i tkiva mogu ispoljavati osobine paramagnetičnosti, odnosno dijamagnetičnosti, ovom metodom moguće je utvrditi dinamiku paramagnetizma i dijamagnetizma na različitim strukturama zuba. Pomoću mikroskopije atomskih sila (engl. atomic force microscopy - AFM) moguće je dobiti topografiju površine uzorka vrlo visoke rezolucije, čime se uočavaju i najmanje promene sve do 10 nm, dok se mikroskopija magnetnih sila (engl. magnetic force microscopy - MFM) koristi za snimanje gradijenta magnetnog polja i njegove raspodele po površini uzorka. Cilj ovog rada bio je da prikaže mogućnosti primene AFM i MFM za karakterizaciju zubnog kamenca, kao i primene OMS za otkrivanje subgingivalnog kalkulusa.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Dental calculus: Nanocharacterization, Zubni kamenac - karakterizacija na nanonivou",
volume = "59",
number = "3",
pages = "154-159",
doi = "10.2298/SGS1203154G"
}
Grga, Đ., Marjanović, M., Hut, I., Dželetović, B.,& Koruga, Đ.. (2012). Dental calculus: Nanocharacterization. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 59(3), 154-159.
https://doi.org/10.2298/SGS1203154G
Grga Đ, Marjanović M, Hut I, Dželetović B, Koruga Đ. Dental calculus: Nanocharacterization. in Stomatološki glasnik Srbije. 2012;59(3):154-159.
doi:10.2298/SGS1203154G .
Grga, Đurica, Marjanović, Marina, Hut, Igor, Dželetović, Bojan, Koruga, Đuro, "Dental calculus: Nanocharacterization" in Stomatološki glasnik Srbije, 59, no. 3 (2012):154-159,
https://doi.org/10.2298/SGS1203154G . .

Deformations of the manual endodontic instruments during root canal instrumentation

Nešković, Jelica; Damjanov, Marija; Živković, Slavoljub; Grga, Đurica; Koruga, Đuro; Kojić, Dušan

(Srpsko lekarsko društvo - Stomatološka sekcija, Beograd, 2010)

TY  - JOUR
AU  - Nešković, Jelica
AU  - Damjanov, Marija
AU  - Živković, Slavoljub
AU  - Grga, Đurica
AU  - Koruga, Đuro
AU  - Kojić, Dušan
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1525
AB  - Introduction. Mechanical instrumentation of the complex root canal system is very demanding procedure which requires use of the various manual and rotary instruments. The aim of this study was to assess the frequency and to verify the possible deformation of the working part of endodontic instruments after their multiple clinical use. Material and Methods. New sets of the manual endodontic instruments (reamers, K-files and Hedstroem) used in routine clinical use (44 instruments) and for root canal instrumentation of extracted teeth (44 instruments) were included in the study. Instrumentation was performed by Step-Back technique and constant irrigation with 0.5% NaOCl solution, 10 ml for each root canal. All the instruments were used 10 times and after use sterilized in a dry sterilizer or autoclave. The working parts of deformed instruments were analyzed using optimagnetic print. Results. The results obtained after clinical use showed deformations of the working part of the reamers in 50%, K-files in 43% and Hedstroem in 66.7% of used instruments. After instrumentation the canal of the extracted teeth, deformations were observed in 87.5% of the reamers, in 50% of the K-files and in 62.5% of Hedstroem files. The difference in frequency of the deformations was not statistically significant. On the instruments used for the preparation the canals of the extracted teeth and sterilized in autoclave, malformations were observed in 86.4%, comparing to the instruments sterilized in a dry sterilizer where malformations of the working part were registered in 59.1% of the cases. That difference was statistically significant (χ2=5.250; p=0.072). Conclusion. Multiple use of the manual endodontic instruments in clinical conditions leads to increased frequency of malformations of the working part in all types of manual endodontic instruments.
AB  - Uvod. Mehanička instrumentacija složenog kanalskog sistema zuba je vrlo težak i komplikovan zahvat i zahteva primenu različitih ručnih i mašinskih rotirajućih instrumenata. Cilj rada je bio da se utvrdi učestalost deformacija radnog dela ručnih endodontskih instrumenata posle njihove višekratne kliničke primene. Materijal i metode rada. U istraživanju su korišćeni setovi novih ručnih endodontskih instrumenata (proširivači tipa K, turpije tipa K, turpije tipa H) koji su korišćeni u rutinskoj kliničkoj primeni (44 instrumenta) i za instrumentaciju kanala ekstrahovanih zuba (44 instrumenta). Kod svih kanala instrumentacija je urađena tzv. step-back tehnikom uz stalnu irigaciju rastvorom NaOCl od 0,5% u količini od 10 ml za svaki kanal. Svi instrumenti su korišćeni deset puta i nakon primene sterilisani u suvom sterilizatoru, odnosno autoklavu. Preseci deformisanih radnih delova instrumenata su analizirani metodom optimagnetnog otiska. Rezultati. Rezultati istraživanja su nakon kliničke primene ukazali na deformacije radnog dela proširivača tipa K kod 50%, turpija tipa K kod 43% i turpija tipa H kod 66,7% korišćenih instrumenata. Nakon instrumentacije kanala ekstrahovanih zuba deformacije kod proširivača su uočene u 87,5%, kod turpija tipa K u 50%, a kod turpija tipa H u 62,5% slučajeva. Razlika u učestalosti deformacija nije bila statistički značajna. Kod instrumenata korišćenih za preparaciju kanala ekstrahovanih zuba i sterilisanih u autoklavu deformacija radnog dela je uočena kod 86,4% njih, a kod sterilisanih u suvom sterilizatoru kod 59,1% instrumenata. Ova razlika je bila statistički značajna (χ2=5,250; p=0,072). Zaključak. Višekratna primena ručnih endodontskih instrumenata u kliničkim uslovima dovodi do povećane učestalosti deformacija radnog dela svih tipova ovih instrumenata.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Deformations of the manual endodontic instruments during root canal instrumentation
T1  - Deformacije ručnih endodontskih instrumenata tokom instrumentacije kanala korena zuba
VL  - 57
IS  - 1
SP  - 21
EP  - 29
DO  - 10.2298/SGS1001021N
ER  - 
@article{
author = "Nešković, Jelica and Damjanov, Marija and Živković, Slavoljub and Grga, Đurica and Koruga, Đuro and Kojić, Dušan",
year = "2010",
abstract = "Introduction. Mechanical instrumentation of the complex root canal system is very demanding procedure which requires use of the various manual and rotary instruments. The aim of this study was to assess the frequency and to verify the possible deformation of the working part of endodontic instruments after their multiple clinical use. Material and Methods. New sets of the manual endodontic instruments (reamers, K-files and Hedstroem) used in routine clinical use (44 instruments) and for root canal instrumentation of extracted teeth (44 instruments) were included in the study. Instrumentation was performed by Step-Back technique and constant irrigation with 0.5% NaOCl solution, 10 ml for each root canal. All the instruments were used 10 times and after use sterilized in a dry sterilizer or autoclave. The working parts of deformed instruments were analyzed using optimagnetic print. Results. The results obtained after clinical use showed deformations of the working part of the reamers in 50%, K-files in 43% and Hedstroem in 66.7% of used instruments. After instrumentation the canal of the extracted teeth, deformations were observed in 87.5% of the reamers, in 50% of the K-files and in 62.5% of Hedstroem files. The difference in frequency of the deformations was not statistically significant. On the instruments used for the preparation the canals of the extracted teeth and sterilized in autoclave, malformations were observed in 86.4%, comparing to the instruments sterilized in a dry sterilizer where malformations of the working part were registered in 59.1% of the cases. That difference was statistically significant (χ2=5.250; p=0.072). Conclusion. Multiple use of the manual endodontic instruments in clinical conditions leads to increased frequency of malformations of the working part in all types of manual endodontic instruments., Uvod. Mehanička instrumentacija složenog kanalskog sistema zuba je vrlo težak i komplikovan zahvat i zahteva primenu različitih ručnih i mašinskih rotirajućih instrumenata. Cilj rada je bio da se utvrdi učestalost deformacija radnog dela ručnih endodontskih instrumenata posle njihove višekratne kliničke primene. Materijal i metode rada. U istraživanju su korišćeni setovi novih ručnih endodontskih instrumenata (proširivači tipa K, turpije tipa K, turpije tipa H) koji su korišćeni u rutinskoj kliničkoj primeni (44 instrumenta) i za instrumentaciju kanala ekstrahovanih zuba (44 instrumenta). Kod svih kanala instrumentacija je urađena tzv. step-back tehnikom uz stalnu irigaciju rastvorom NaOCl od 0,5% u količini od 10 ml za svaki kanal. Svi instrumenti su korišćeni deset puta i nakon primene sterilisani u suvom sterilizatoru, odnosno autoklavu. Preseci deformisanih radnih delova instrumenata su analizirani metodom optimagnetnog otiska. Rezultati. Rezultati istraživanja su nakon kliničke primene ukazali na deformacije radnog dela proširivača tipa K kod 50%, turpija tipa K kod 43% i turpija tipa H kod 66,7% korišćenih instrumenata. Nakon instrumentacije kanala ekstrahovanih zuba deformacije kod proširivača su uočene u 87,5%, kod turpija tipa K u 50%, a kod turpija tipa H u 62,5% slučajeva. Razlika u učestalosti deformacija nije bila statistički značajna. Kod instrumenata korišćenih za preparaciju kanala ekstrahovanih zuba i sterilisanih u autoklavu deformacija radnog dela je uočena kod 86,4% njih, a kod sterilisanih u suvom sterilizatoru kod 59,1% instrumenata. Ova razlika je bila statistički značajna (χ2=5,250; p=0,072). Zaključak. Višekratna primena ručnih endodontskih instrumenata u kliničkim uslovima dovodi do povećane učestalosti deformacija radnog dela svih tipova ovih instrumenata.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Deformations of the manual endodontic instruments during root canal instrumentation, Deformacije ručnih endodontskih instrumenata tokom instrumentacije kanala korena zuba",
volume = "57",
number = "1",
pages = "21-29",
doi = "10.2298/SGS1001021N"
}
Nešković, J., Damjanov, M., Živković, S., Grga, Đ., Koruga, Đ.,& Kojić, D.. (2010). Deformations of the manual endodontic instruments during root canal instrumentation. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 57(1), 21-29.
https://doi.org/10.2298/SGS1001021N
Nešković J, Damjanov M, Živković S, Grga Đ, Koruga Đ, Kojić D. Deformations of the manual endodontic instruments during root canal instrumentation. in Stomatološki glasnik Srbije. 2010;57(1):21-29.
doi:10.2298/SGS1001021N .
Nešković, Jelica, Damjanov, Marija, Živković, Slavoljub, Grga, Đurica, Koruga, Đuro, Kojić, Dušan, "Deformations of the manual endodontic instruments during root canal instrumentation" in Stomatološki glasnik Srbije, 57, no. 1 (2010):21-29,
https://doi.org/10.2298/SGS1001021N . .
1