TY  - JOUR
AU  - Trifunović, Jovanka
AU  - Basta-Jovanović, Gordana
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Marjanović, Ana
AU  - Branković, Marija
AU  - Radojević-Škodrić, Sanja
AU  - Prvanović, Mirjana
AU  - Jovanović, Aleksandar
AU  - Džamić, Zoran
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2272
AB  - Purpose: Renal cell carcinoma (RCC) is the most common renal cancer in adults and includes several subtypes that may be distinguished by their histology, genetic background, clinical course and responses to treatment. Human telomerase reverse transcriptase (hTERT), a crucial enzyme for telomere maintenance, has been linked to RCC development. The purpose of this study was to search for genetic and epigenetic alterations in hTERT (promoter mutations and methylation and gene amplification), and to establish a possible association between molecular and clinico-pathological characteristics of RCC. Methods: DNA was extracted from 31 formalin fixed, para,, n-embedded tumor samples and 23 blood samples from 54 patients with RCC. Polymerase chain reaction (PCR) products were sequenced and analyzed using the Sequencher software. HTERT amplification was determined by quantitative PCR, while the promoter methylation status was assessed by methylation specific PCR. Statistical analysis was performed using SPSS. Results: No mutations could be detected in the hTERT promoter but only a single nucleotide polymorphism (SNP) (-245 T > C). In 54 analyzed RCC cases, the variant allele C was present in homozygous or heterozygous form in 48% of the patients. The C allele was significantly more frequent in low grade tumors (p=0.046). Gene amplification was detected in 19.4% of the 31 RCCs and hTERT methylation in 54.8% of the 31 samples. An association was established between methylation and histological type of RCC (p=0.047). Conclusions: HTERT seems to be implicated in RCC pathogenesis since the promoter polymorphism exerts a modulation effect on tumor behavior. In addition, hTERT promoter methylation status is related to RCC histology.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - HTERT promoter methylation and single nucleotide polymorphism (-245 T > C) affect renal cell carcinoma behavior in Serbian population
VL  - 23
IS  - 6
SP  - 1887
EP  - 1892
UR  - https://hdl.handle.net/21.15107/rcub_smile_2272
ER  - 

@article{
author = "Trifunović, Jovanka and Basta-Jovanović, Gordana and Nikolić, Nadja and Čarkić, Jelena and Marjanović, Ana and Branković, Marija and Radojević-Škodrić, Sanja and Prvanović, Mirjana and Jovanović, Aleksandar and Džamić, Zoran and Milašin, Jelena",
year = "2018",
abstract = "Purpose: Renal cell carcinoma (RCC) is the most common renal cancer in adults and includes several subtypes that may be distinguished by their histology, genetic background, clinical course and responses to treatment. Human telomerase reverse transcriptase (hTERT), a crucial enzyme for telomere maintenance, has been linked to RCC development. The purpose of this study was to search for genetic and epigenetic alterations in hTERT (promoter mutations and methylation and gene amplification), and to establish a possible association between molecular and clinico-pathological characteristics of RCC. Methods: DNA was extracted from 31 formalin fixed, para,, n-embedded tumor samples and 23 blood samples from 54 patients with RCC. Polymerase chain reaction (PCR) products were sequenced and analyzed using the Sequencher software. HTERT amplification was determined by quantitative PCR, while the promoter methylation status was assessed by methylation specific PCR. Statistical analysis was performed using SPSS. Results: No mutations could be detected in the hTERT promoter but only a single nucleotide polymorphism (SNP) (-245 T > C). In 54 analyzed RCC cases, the variant allele C was present in homozygous or heterozygous form in 48% of the patients. The C allele was significantly more frequent in low grade tumors (p=0.046). Gene amplification was detected in 19.4% of the 31 RCCs and hTERT methylation in 54.8% of the 31 samples. An association was established between methylation and histological type of RCC (p=0.047). Conclusions: HTERT seems to be implicated in RCC pathogenesis since the promoter polymorphism exerts a modulation effect on tumor behavior. In addition, hTERT promoter methylation status is related to RCC histology.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "HTERT promoter methylation and single nucleotide polymorphism (-245 T > C) affect renal cell carcinoma behavior in Serbian population",
volume = "23",
number = "6",
pages = "1887-1892",
url = "https://hdl.handle.net/21.15107/rcub_smile_2272"
}

Trifunović, J., Basta-Jovanović, G., Nikolić, N., Čarkić, J., Marjanović, A., Branković, M., Radojević-Škodrić, S., Prvanović, M., Jovanović, A., Džamić, Z.,& Milašin, J.. (2018). HTERT promoter methylation and single nucleotide polymorphism (-245 T > C) affect renal cell carcinoma behavior in Serbian population. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 23(6), 1887-1892.
https://hdl.handle.net/21.15107/rcub_smile_2272

Trifunović J, Basta-Jovanović G, Nikolić N, Čarkić J, Marjanović A, Branković M, Radojević-Škodrić S, Prvanović M, Jovanović A, Džamić Z, Milašin J. HTERT promoter methylation and single nucleotide polymorphism (-245 T > C) affect renal cell carcinoma behavior in Serbian population. in Journal of BUON. 2018;23(6):1887-1892.
https://hdl.handle.net/21.15107/rcub_smile_2272 .

Trifunović, Jovanka, Basta-Jovanović, Gordana, Nikolić, Nadja, Čarkić, Jelena, Marjanović, Ana, Branković, Marija, Radojević-Škodrić, Sanja, Prvanović, Mirjana, Jovanović, Aleksandar, Džamić, Zoran, Milašin, Jelena, "HTERT promoter methylation and single nucleotide polymorphism (-245 T > C) affect renal cell carcinoma behavior in Serbian population" in Journal of BUON, 23, no. 6 (2018):1887-1892,
https://hdl.handle.net/21.15107/rcub_smile_2272 .

TY  - CONF
AU  - Miloševski-Lomić, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Basta-Jovanović, Gordana
AU  - Kostić, Mirjana
AU  - Miličić, Biljana
AU  - Paripović, Dušan
AU  - Nikolovski, SrDan
AU  - Spasojević-Dimitrijeva, Brankica
AU  - Gojović, Ivana
AU  - Cvetković, Mirjana
AU  - Kruscić, Divna
AU  - Peco-Antić, Amira
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2320
PB  - Springer, New York
C3  - Pediatric Nephrology
T1  - Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies
VL  - 33
IS  - 10
SP  - 1873
EP  - 1873
UR  - https://hdl.handle.net/21.15107/rcub_smile_2320
ER  - 

@conference{
author = "Miloševski-Lomić, Gordana and Radojević-Škodrić, Sanja and Basta-Jovanović, Gordana and Kostić, Mirjana and Miličić, Biljana and Paripović, Dušan and Nikolovski, SrDan and Spasojević-Dimitrijeva, Brankica and Gojović, Ivana and Cvetković, Mirjana and Kruscić, Divna and Peco-Antić, Amira",
year = "2018",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies",
volume = "33",
number = "10",
pages = "1873-1873",
url = "https://hdl.handle.net/21.15107/rcub_smile_2320"
}

Miloševski-Lomić, G., Radojević-Škodrić, S., Basta-Jovanović, G., Kostić, M., Miličić, B., Paripović, D., Nikolovski, S., Spasojević-Dimitrijeva, B., Gojović, I., Cvetković, M., Kruscić, D.,& Peco-Antić, A.. (2018). Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies. in Pediatric Nephrology
Springer, New York., 33(10), 1873-1873.
https://hdl.handle.net/21.15107/rcub_smile_2320

Miloševski-Lomić G, Radojević-Škodrić S, Basta-Jovanović G, Kostić M, Miličić B, Paripović D, Nikolovski S, Spasojević-Dimitrijeva B, Gojović I, Cvetković M, Kruscić D, Peco-Antić A. Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies. in Pediatric Nephrology. 2018;33(10):1873-1873.
https://hdl.handle.net/21.15107/rcub_smile_2320 .

Miloševski-Lomić, Gordana, Radojević-Škodrić, Sanja, Basta-Jovanović, Gordana, Kostić, Mirjana, Miličić, Biljana, Paripović, Dušan, Nikolovski, SrDan, Spasojević-Dimitrijeva, Brankica, Gojović, Ivana, Cvetković, Mirjana, Kruscić, Divna, Peco-Antić, Amira, "Tubulointerstitial expression of kidney injury molecule-1 in children with chronic glomerulopathies" in Pediatric Nephrology, 33, no. 10 (2018):1873-1873,
https://hdl.handle.net/21.15107/rcub_smile_2320 .

TY  - JOUR
AU  - Bogdanović, Ljiljana
AU  - Lazić, Miodrag
AU  - Bogdanović, Jelena
AU  - Soldatović, Ivan
AU  - Nikolić, Nadja
AU  - Radunović, Milena
AU  - Radojević-Škodrić, Sanja
AU  - Milašin, Jelena
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2182
AB  - Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population
VL  - 22
IS  - 1
SP  - 270
EP  - 277
UR  - https://hdl.handle.net/21.15107/rcub_smile_2182
ER  - 

@article{
author = "Bogdanović, Ljiljana and Lazić, Miodrag and Bogdanović, Jelena and Soldatović, Ivan and Nikolić, Nadja and Radunović, Milena and Radojević-Škodrić, Sanja and Milašin, Jelena and Basta-Jovanović, Gordana",
year = "2017",
abstract = "Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population",
volume = "22",
number = "1",
pages = "270-277",
url = "https://hdl.handle.net/21.15107/rcub_smile_2182"
}

Bogdanović, L., Lazić, M., Bogdanović, J., Soldatović, I., Nikolić, N., Radunović, M., Radojević-Škodrić, S., Milašin, J.,& Basta-Jovanović, G.. (2017). Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(1), 270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182

Bogdanović L, Lazić M, Bogdanović J, Soldatović I, Nikolić N, Radunović M, Radojević-Škodrić S, Milašin J, Basta-Jovanović G. Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON. 2017;22(1):270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182 .

Bogdanović, Ljiljana, Lazić, Miodrag, Bogdanović, Jelena, Soldatović, Ivan, Nikolić, Nadja, Radunović, Milena, Radojević-Škodrić, Sanja, Milašin, Jelena, Basta-Jovanović, Gordana, "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population" in Journal of BUON, 22, no. 1 (2017):270-277,
https://hdl.handle.net/21.15107/rcub_smile_2182 .

TY  - JOUR
AU  - Latić, Dragana
AU  - Radojević-Škodrić, Sanja
AU  - Nikolić, Srđan
AU  - Prvanović, Mirjana
AU  - Lazić, Miodrag
AU  - Džamić, Zoran
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Vuković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2206
AB  - Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
VL  - 22
IS  - 5
SP  - 1322
EP  - 1327
UR  - https://hdl.handle.net/21.15107/rcub_smile_2206
ER  - 

@article{
author = "Latić, Dragana and Radojević-Škodrić, Sanja and Nikolić, Srđan and Prvanović, Mirjana and Lazić, Miodrag and Džamić, Zoran and Bogdanović, Ljiljana and Radunović, Milena and Vuković, Marina",
year = "2017",
abstract = "Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma",
volume = "22",
number = "5",
pages = "1322-1327",
url = "https://hdl.handle.net/21.15107/rcub_smile_2206"
}

Latić, D., Radojević-Škodrić, S., Nikolić, S., Prvanović, M., Lazić, M., Džamić, Z., Bogdanović, L., Radunović, M.,& Vuković, M.. (2017). Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(5), 1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206

Latić D, Radojević-Škodrić S, Nikolić S, Prvanović M, Lazić M, Džamić Z, Bogdanović L, Radunović M, Vuković M. Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON. 2017;22(5):1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206 .

Latić, Dragana, Radojević-Škodrić, Sanja, Nikolić, Srđan, Prvanović, Mirjana, Lazić, Miodrag, Džamić, Zoran, Bogdanović, Ljiljana, Radunović, Milena, Vuković, Marina, "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma" in Journal of BUON, 22, no. 5 (2017):1322-1327,
https://hdl.handle.net/21.15107/rcub_smile_2206 .

TY  - JOUR
AU  - Čarkić, Jelena
AU  - Nikolić, Nadja
AU  - Radojević-Škodrić, Sanja
AU  - Kuzmanović-Pfićer, Jovana
AU  - Brajović, Gavrilo
AU  - Antunović, Marija
AU  - Milašin, Jelena
AU  - Popović, Branka
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2115
AB  - The aim of this study was to assess TERT-CLPTM1L single-nucleotide polymorphisms (SNPs) (rs402710 C/T in the CLPTM1L gene; rs2736100 A/C and rs2736098 G/A in the TERT gene) as risk factors for development of oral squamous cell carcinoma (OSCC), and to investigate the relationship between the analyzed polymorphisms, relative telomere length (RTL), telomerase expression and clinicopathologic characteristics of OSCC in a Serbian population. Paraffin-embedded tumor samples and buccal swabs from cancer-free controls were genotyped using PCR-RFLP, while tumor RTL values and telomerase expression were estimated by real-time PCR and immunohistochemistry, respectively. CLPTM1L rs402710 and TERT rs2736100 polymorphisms were associated with a significantly increased risk of OSCC, and TERT rs2736098 with a significantly decreased risk. No significant association was found between TERT-CLPTM1L polymorphisms, tumor RTL values, telomerase expression, and clinicopathologic features, although a trend towards longer telomeres was evident in telomerase-positive samples and less advanced tumors. Kaplan-Meier survival analysis showed that patients with longer telomeres in their tumors had significantly better overall survival than patients with shorter telomeres. Our research seems to provide strong evidence for an association between CLPTMIL rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers.
PB  - Nihon Univ, School Dentistry, Toyko
T2  - Journal of Oral Science
T1  - The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma
VL  - 58
IS  - 4
SP  - 449
EP  - 458
DO  - 10.2334/josnusd.16-0108
ER  - 

@article{
author = "Čarkić, Jelena and Nikolić, Nadja and Radojević-Škodrić, Sanja and Kuzmanović-Pfićer, Jovana and Brajović, Gavrilo and Antunović, Marija and Milašin, Jelena and Popović, Branka",
year = "2016",
abstract = "The aim of this study was to assess TERT-CLPTM1L single-nucleotide polymorphisms (SNPs) (rs402710 C/T in the CLPTM1L gene; rs2736100 A/C and rs2736098 G/A in the TERT gene) as risk factors for development of oral squamous cell carcinoma (OSCC), and to investigate the relationship between the analyzed polymorphisms, relative telomere length (RTL), telomerase expression and clinicopathologic characteristics of OSCC in a Serbian population. Paraffin-embedded tumor samples and buccal swabs from cancer-free controls were genotyped using PCR-RFLP, while tumor RTL values and telomerase expression were estimated by real-time PCR and immunohistochemistry, respectively. CLPTM1L rs402710 and TERT rs2736100 polymorphisms were associated with a significantly increased risk of OSCC, and TERT rs2736098 with a significantly decreased risk. No significant association was found between TERT-CLPTM1L polymorphisms, tumor RTL values, telomerase expression, and clinicopathologic features, although a trend towards longer telomeres was evident in telomerase-positive samples and less advanced tumors. Kaplan-Meier survival analysis showed that patients with longer telomeres in their tumors had significantly better overall survival than patients with shorter telomeres. Our research seems to provide strong evidence for an association between CLPTMIL rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers.",
publisher = "Nihon Univ, School Dentistry, Toyko",
journal = "Journal of Oral Science",
title = "The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma",
volume = "58",
number = "4",
pages = "449-458",
doi = "10.2334/josnusd.16-0108"
}

Čarkić, J., Nikolić, N., Radojević-Škodrić, S., Kuzmanović-Pfićer, J., Brajović, G., Antunović, M., Milašin, J.,& Popović, B.. (2016). The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma. in Journal of Oral Science
Nihon Univ, School Dentistry, Toyko., 58(4), 449-458.
https://doi.org/10.2334/josnusd.16-0108

Čarkić J, Nikolić N, Radojević-Škodrić S, Kuzmanović-Pfićer J, Brajović G, Antunović M, Milašin J, Popović B. The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma. in Journal of Oral Science. 2016;58(4):449-458.
doi:10.2334/josnusd.16-0108 .

Čarkić, Jelena, Nikolić, Nadja, Radojević-Škodrić, Sanja, Kuzmanović-Pfićer, Jovana, Brajović, Gavrilo, Antunović, Marija, Milašin, Jelena, Popović, Branka, "The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma" in Journal of Oral Science, 58, no. 4 (2016):449-458,
https://doi.org/10.2334/josnusd.16-0108 . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Prostran, Milica S.
AU  - Naumović, R.
AU  - Simić-Ogrizović, Sanja
AU  - Radojević-Škodrić, Sanja
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2094
AB  - Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation
VL  - 23
IS  - 19
SP  - 2012
EP  - 2017
DO  - 10.2174/092986732319160719192019
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Bogdanović, Ljiljana and Radunović, Milena and Prostran, Milica S. and Naumović, R. and Simić-Ogrizović, Sanja and Radojević-Škodrić, Sanja",
year = "2016",
abstract = "Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation",
volume = "23",
number = "19",
pages = "2012-2017",
doi = "10.2174/092986732319160719192019"
}

Basta-Jovanović, G., Bogdanović, L., Radunović, M., Prostran, M. S., Naumović, R., Simić-Ogrizović, S.,& Radojević-Škodrić, S.. (2016). Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 23(19), 2012-2017.
https://doi.org/10.2174/092986732319160719192019

Basta-Jovanović G, Bogdanović L, Radunović M, Prostran MS, Naumović R, Simić-Ogrizović S, Radojević-Škodrić S. Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry. 2016;23(19):2012-2017.
doi:10.2174/092986732319160719192019 .

Basta-Jovanović, Gordana, Bogdanović, Ljiljana, Radunović, Milena, Prostran, Milica S., Naumović, R., Simić-Ogrizović, Sanja, Radojević-Škodrić, Sanja, "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation" in Current Medicinal Chemistry, 23, no. 19 (2016):2012-2017,
https://doi.org/10.2174/092986732319160719192019 . .

TY  - JOUR
AU  - Radunović, Milena
AU  - Tomanović, Nada
AU  - Novaković, Ivana
AU  - Boričić, Ivan
AU  - Milenković, Sanja
AU  - Dimitrijević, Milovan
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, Ljiljana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2077
AB  - Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer
VL  - 21
IS  - 6
SP  - 1530
EP  - 1536
UR  - https://hdl.handle.net/21.15107/rcub_smile_2077
ER  - 

@article{
author = "Radunović, Milena and Tomanović, Nada and Novaković, Ivana and Boričić, Ivan and Milenković, Sanja and Dimitrijević, Milovan and Radojević-Škodrić, Sanja and Bogdanović, Ljiljana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer",
volume = "21",
number = "6",
pages = "1530-1536",
url = "https://hdl.handle.net/21.15107/rcub_smile_2077"
}

Radunović, M., Tomanović, N., Novaković, I., Boričić, I., Milenković, S., Dimitrijević, M., Radojević-Škodrić, S., Bogdanović, L.,& Basta-Jovanović, G.. (2016). Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(6), 1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077

Radunović M, Tomanović N, Novaković I, Boričić I, Milenković S, Dimitrijević M, Radojević-Škodrić S, Bogdanović L, Basta-Jovanović G. Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON. 2016;21(6):1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077 .

Radunović, Milena, Tomanović, Nada, Novaković, Ivana, Boričić, Ivan, Milenković, Sanja, Dimitrijević, Milovan, Radojević-Škodrić, Sanja, Bogdanović, Ljiljana, Basta-Jovanović, Gordana, "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer" in Journal of BUON, 21, no. 6 (2016):1530-1536,
https://hdl.handle.net/21.15107/rcub_smile_2077 .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Basta-Jovanović, Gordana
AU  - Brašanac, Dimitrije
AU  - Nikolić, Nadja
AU  - Bogdanović, Ljiljana
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1744
AB  - Survivin, an apoptotic inhibitor, is overexpressed in various types of cancer. Mechanisms of survivin upregulation are still poorly understood, but single nucleotide polymorphisms in the survivin gene promoter have been shown to modulate survivin expression and consequently the risk for some types of cancer. The aim of the present study was to investigate whether survivin promoter -31 G/C and -241 C/T polymorphisms could represent susceptibility factors for Wilms tumor (WT) development in Serbian population. Genotype and allele frequencies for the 2 polymorphisms in survivin promoter have been analyzed by polymerase chain reaction/restriction fragment length polymorphism in 59 WT patients and 82 controls. The frequencies of alleles and genotypes were significantly different between patients and controls for the -31 G/C polymorphism. Individuals with CC and CG genotypes had significantly decreased risk of WT compared with GG individuals (odds ratio 0.26, 95% confidence interval, 0.07-0.96; odds ratio 0.30, 95% confidence interval, 0.15-0.60). There was also a statistically significant difference in genotype frequencies between intermediate and high-risk prognostic groups (P = 0.015). The -241 C/T polymorphism did not show association with WT susceptibility. Our findings suggest that the G allele at -31 survivin gene promoter position is associated with a significantly higher cancer risk in Serbian children, with a gene dosage effect.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Pediatric Hematology Oncology
T1  - Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children
VL  - 34
IS  - 8
SP  - E310
EP  - E314
DO  - 10.1097/MPH.0b013e31825d3076
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Basta-Jovanović, Gordana and Brašanac, Dimitrije and Nikolić, Nadja and Bogdanović, Ljiljana and Miličić, Biljana and Milašin, Jelena",
year = "2012",
abstract = "Survivin, an apoptotic inhibitor, is overexpressed in various types of cancer. Mechanisms of survivin upregulation are still poorly understood, but single nucleotide polymorphisms in the survivin gene promoter have been shown to modulate survivin expression and consequently the risk for some types of cancer. The aim of the present study was to investigate whether survivin promoter -31 G/C and -241 C/T polymorphisms could represent susceptibility factors for Wilms tumor (WT) development in Serbian population. Genotype and allele frequencies for the 2 polymorphisms in survivin promoter have been analyzed by polymerase chain reaction/restriction fragment length polymorphism in 59 WT patients and 82 controls. The frequencies of alleles and genotypes were significantly different between patients and controls for the -31 G/C polymorphism. Individuals with CC and CG genotypes had significantly decreased risk of WT compared with GG individuals (odds ratio 0.26, 95% confidence interval, 0.07-0.96; odds ratio 0.30, 95% confidence interval, 0.15-0.60). There was also a statistically significant difference in genotype frequencies between intermediate and high-risk prognostic groups (P = 0.015). The -241 C/T polymorphism did not show association with WT susceptibility. Our findings suggest that the G allele at -31 survivin gene promoter position is associated with a significantly higher cancer risk in Serbian children, with a gene dosage effect.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Pediatric Hematology Oncology",
title = "Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children",
volume = "34",
number = "8",
pages = "E310-E314",
doi = "10.1097/MPH.0b013e31825d3076"
}

Radojević-Škodrić, S., Basta-Jovanović, G., Brašanac, D., Nikolić, N., Bogdanović, L., Miličić, B.,& Milašin, J.. (2012). Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children. in Journal of Pediatric Hematology Oncology
Lippincott Williams & Wilkins, Philadelphia., 34(8), E310-E314.
https://doi.org/10.1097/MPH.0b013e31825d3076

Radojević-Škodrić S, Basta-Jovanović G, Brašanac D, Nikolić N, Bogdanović L, Miličić B, Milašin J. Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children. in Journal of Pediatric Hematology Oncology. 2012;34(8):E310-E314.
doi:10.1097/MPH.0b013e31825d3076 .

Radojević-Škodrić, Sanja, Basta-Jovanović, Gordana, Brašanac, Dimitrije, Nikolić, Nadja, Bogdanović, Ljiljana, Miličić, Biljana, Milašin, Jelena, "Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children" in Journal of Pediatric Hematology Oncology, 34, no. 8 (2012):E310-E314,
https://doi.org/10.1097/MPH.0b013e31825d3076 . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuricić, S.
AU  - Milašin, Jelena
AU  - Bogdanović, L.
AU  - Oprić, D.
AU  - Savin, M.
AU  - Baralić, I.
AU  - Jovanović, M.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1747
AB  - Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Prognostic value of survivin expression in Wilms tumor
VL  - 17
IS  - 1
SP  - 168
EP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_smile_1747
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuricić, S. and Milašin, Jelena and Bogdanović, L. and Oprić, D. and Savin, M. and Baralić, I. and Jovanović, M.",
year = "2012",
abstract = "Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Prognostic value of survivin expression in Wilms tumor",
volume = "17",
number = "1",
pages = "168-173",
url = "https://hdl.handle.net/21.15107/rcub_smile_1747"
}

Basta-Jovanović, G., Radojević-Škodrić, S., Brašanac, D., Đuricić, S., Milašin, J., Bogdanović, L., Oprić, D., Savin, M., Baralić, I.,& Jovanović, M.. (2012). Prognostic value of survivin expression in Wilms tumor. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747

Basta-Jovanović G, Radojević-Škodrić S, Brašanac D, Đuricić S, Milašin J, Bogdanović L, Oprić D, Savin M, Baralić I, Jovanović M. Prognostic value of survivin expression in Wilms tumor. in Journal of BUON. 2012;17(1):168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747 .

Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Brašanac, Dimitrije, Đuricić, S., Milašin, Jelena, Bogdanović, L., Oprić, D., Savin, M., Baralić, I., Jovanović, M., "Prognostic value of survivin expression in Wilms tumor" in Journal of BUON, 17, no. 1 (2012):168-173,
https://hdl.handle.net/21.15107/rcub_smile_1747 .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Suzić, S.
AU  - Savin, M.
AU  - Petronijević, Nataša
AU  - Radonjić, N.
AU  - Signuričić, S.
AU  - Vučković, Mila
AU  - Radojević-Škodrić, Sanja
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1408
AB  - Proliferative disorders including tumors are recognized as diseases of the cell cycle in which the crucial role belongs to the cyclin-dependent kinase family. The aim of this study was to investigate the expression of protein p16 in the normal kidney, and in Wilms tumor by immunohistochemistry to correlate the obtained results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/III, showing no statistically significant correlation (p > 0.05). Intermediate risk groups of Wilms tumor showed more frequent p16 expression in comparison with high risk cases, showing no statistical significance (p > 0.05). Protein p16 expression was detected in all histologic types of Wilms tumor with the highest expression in the predominantly blastemal type (50%). There was a statistically significant difference between p16 expression in this and its expression in other histological types (p  lt  0.05). The correlation between p16 expression and the predominantly blastemal histological type was statistically significant and showed that in such cases tumor cells can proliferate even in the presence of p16.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria
T1  - Immunohistochemical expression of protein p16 in Wilms' tumor
VL  - 58
IS  - 4
SP  - 297
EP  - 306
DO  - 10.2298/AVB0804297B
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Suzić, S. and Savin, M. and Petronijević, Nataša and Radonjić, N. and Signuričić, S. and Vučković, Mila and Radojević-Škodrić, Sanja",
year = "2008",
abstract = "Proliferative disorders including tumors are recognized as diseases of the cell cycle in which the crucial role belongs to the cyclin-dependent kinase family. The aim of this study was to investigate the expression of protein p16 in the normal kidney, and in Wilms tumor by immunohistochemistry to correlate the obtained results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/III, showing no statistically significant correlation (p > 0.05). Intermediate risk groups of Wilms tumor showed more frequent p16 expression in comparison with high risk cases, showing no statistical significance (p > 0.05). Protein p16 expression was detected in all histologic types of Wilms tumor with the highest expression in the predominantly blastemal type (50%). There was a statistically significant difference between p16 expression in this and its expression in other histological types (p  lt  0.05). The correlation between p16 expression and the predominantly blastemal histological type was statistically significant and showed that in such cases tumor cells can proliferate even in the presence of p16.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria",
title = "Immunohistochemical expression of protein p16 in Wilms' tumor",
volume = "58",
number = "4",
pages = "297-306",
doi = "10.2298/AVB0804297B"
}

Basta-Jovanović, G., Suzić, S., Savin, M., Petronijević, N., Radonjić, N., Signuričić, S., Vučković, M.,& Radojević-Škodrić, S.. (2008). Immunohistochemical expression of protein p16 in Wilms' tumor. in Acta Veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(4), 297-306.
https://doi.org/10.2298/AVB0804297B

Basta-Jovanović G, Suzić S, Savin M, Petronijević N, Radonjić N, Signuričić S, Vučković M, Radojević-Škodrić S. Immunohistochemical expression of protein p16 in Wilms' tumor. in Acta Veterinaria. 2008;58(4):297-306.
doi:10.2298/AVB0804297B .

Basta-Jovanović, Gordana, Suzić, S., Savin, M., Petronijević, Nataša, Radonjić, N., Signuričić, S., Vučković, Mila, Radojević-Škodrić, Sanja, "Immunohistochemical expression of protein p16 in Wilms' tumor" in Acta Veterinaria, 58, no. 4 (2008):297-306,
https://doi.org/10.2298/AVB0804297B . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Gvozdenović, E.
AU  - Dimitrijević, I.
AU  - Brašanac, Dimitrije
AU  - Vučković, Mila
AU  - Kalezić, Nevena
AU  - Baralić, I.
AU  - Radojević-Škodrić, Sanja
AU  - Arsić, D.
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1395
AB  - The aim of our study was to investigate the expression of γ-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of γ-catenin was detected in 14 cases. There was a weak inverse relationship between γ-catenin expression and tumor stage. Expression of γ-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor γ-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of γ-catenin and unfavorable outcome.
T2  - Fetal & Pediatric Pathology
T1  - Immunohistochemical analysis of gamma catenin in Wilms' tumors
VL  - 27
IS  - 2
SP  - 63
EP  - 70
DO  - 10.1080/15513810802028704
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Gvozdenović, E. and Dimitrijević, I. and Brašanac, Dimitrije and Vučković, Mila and Kalezić, Nevena and Baralić, I. and Radojević-Škodrić, Sanja and Arsić, D.",
year = "2008",
abstract = "The aim of our study was to investigate the expression of γ-catenin in normal kidney and in Wilms' tumor by immunohistochemistry and to correlate the results with tumor stage, histological type, and prognostic group. We investigated 28 cases of Wilms' tumor, 2 Wilms' tumor metastases in lungs, and 1 specimen of normal renal tissue. Expression of γ-catenin was detected in 14 cases. There was a weak inverse relationship between γ-catenin expression and tumor stage. Expression of γ-catenin was detected in various histologic types of Wilms' tumor, but there was no statistically significant correlation, except in cases with diffuse anaplasia that were negative. In 2 metastatic cases and in the case of bilateral Wilms' tumor γ-catenin immunostaining was not observed Our findings suggest an absence of strong correlation between the loss of γ-catenin and unfavorable outcome.",
journal = "Fetal & Pediatric Pathology",
title = "Immunohistochemical analysis of gamma catenin in Wilms' tumors",
volume = "27",
number = "2",
pages = "63-70",
doi = "10.1080/15513810802028704"
}

Basta-Jovanović, G., Gvozdenović, E., Dimitrijević, I., Brašanac, D., Vučković, M., Kalezić, N., Baralić, I., Radojević-Škodrić, S.,& Arsić, D.. (2008). Immunohistochemical analysis of gamma catenin in Wilms' tumors. in Fetal & Pediatric Pathology, 27(2), 63-70.
https://doi.org/10.1080/15513810802028704

Basta-Jovanović G, Gvozdenović E, Dimitrijević I, Brašanac D, Vučković M, Kalezić N, Baralić I, Radojević-Škodrić S, Arsić D. Immunohistochemical analysis of gamma catenin in Wilms' tumors. in Fetal & Pediatric Pathology. 2008;27(2):63-70.
doi:10.1080/15513810802028704 .

Basta-Jovanović, Gordana, Gvozdenović, E., Dimitrijević, I., Brašanac, Dimitrije, Vučković, Mila, Kalezić, Nevena, Baralić, I., Radojević-Škodrić, Sanja, Arsić, D., "Immunohistochemical analysis of gamma catenin in Wilms' tumors" in Fetal & Pediatric Pathology, 27, no. 2 (2008):63-70,
https://doi.org/10.1080/15513810802028704 . .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Jovanović, M.
AU  - Bogdanović, L.
AU  - Bogdanović, R.
AU  - Ležaić, Višnja
AU  - Nesić, V.
AU  - Dikman, S.
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1393
AB  - INTRODUCTION: Two types of hereditary nephritis, nonprogressive and progressive, clinically present as asymptomatic haematuria, sometimes combined with proteinuria. At the onset, in both types, light microscopic changes are minimal, immunofluorescence findings are negative, and diagnosis can be made only upon electron microscopic findings that are considered to be specific. OBJECTIVE: The aim of this study was to determine the significance of Goodpasture antigen detection in diagnosis of progressive and nonprogressive hereditary nephritis in its early phase. METHOD: Analysis of renal biopsy specimens was done in patients with hereditary nephritis that were followed from 1990 to 2005. Progression of renal disease was examined in 14 patients with Alport's syndrome, 10 patients with thin basement membrane disease, and 6 patients with unclassified hereditary nephritis diagnosed. For all these cases, indirect immunofluorescence study with serum from a patient with high titer of Goodpasture autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane was performed. RESULTS: In 11 out of 14 cases diagnosed as Alport's syndrome, there was negative staining with Goodpasture serum, and in 3 additional cases with Alport's syndrome, expression of Goodpasture antigen in glomerular basement membrane and thin basement membrane was highly reduced. In all 10 patients with thin basement membrane disease, immunofluorescence showed intensive, bright linear staining with Goodpasture serum along glomerular and tubular basement membrane. In 2 out of 6 patients with unclassified hereditary nephritis, Goodpasture antigen expression was very strong, in one patient it was very reduced, and in 3 patients it was negative. CONCLUSION: The results of our study show that Goodpasture antigen detection plays a very important role in differential diagnosis of progressive and nonpregressive hereditary nephritis, particularly in early phases of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The significance of Goodpasture antigen in hereditary nephritis
VL  - 136 Suppl 4
SP  - 282
EP  - 286
DO  - 10.2298/SARH08S4282B
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Jovanović, M. and Bogdanović, L. and Bogdanović, R. and Ležaić, Višnja and Nesić, V. and Dikman, S.",
year = "2008",
abstract = "INTRODUCTION: Two types of hereditary nephritis, nonprogressive and progressive, clinically present as asymptomatic haematuria, sometimes combined with proteinuria. At the onset, in both types, light microscopic changes are minimal, immunofluorescence findings are negative, and diagnosis can be made only upon electron microscopic findings that are considered to be specific. OBJECTIVE: The aim of this study was to determine the significance of Goodpasture antigen detection in diagnosis of progressive and nonprogressive hereditary nephritis in its early phase. METHOD: Analysis of renal biopsy specimens was done in patients with hereditary nephritis that were followed from 1990 to 2005. Progression of renal disease was examined in 14 patients with Alport's syndrome, 10 patients with thin basement membrane disease, and 6 patients with unclassified hereditary nephritis diagnosed. For all these cases, indirect immunofluorescence study with serum from a patient with high titer of Goodpasture autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane was performed. RESULTS: In 11 out of 14 cases diagnosed as Alport's syndrome, there was negative staining with Goodpasture serum, and in 3 additional cases with Alport's syndrome, expression of Goodpasture antigen in glomerular basement membrane and thin basement membrane was highly reduced. In all 10 patients with thin basement membrane disease, immunofluorescence showed intensive, bright linear staining with Goodpasture serum along glomerular and tubular basement membrane. In 2 out of 6 patients with unclassified hereditary nephritis, Goodpasture antigen expression was very strong, in one patient it was very reduced, and in 3 patients it was negative. CONCLUSION: The results of our study show that Goodpasture antigen detection plays a very important role in differential diagnosis of progressive and nonpregressive hereditary nephritis, particularly in early phases of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The significance of Goodpasture antigen in hereditary nephritis",
volume = "136 Suppl 4",
pages = "282-286",
doi = "10.2298/SARH08S4282B"
}

Basta-Jovanović, G., Radojević-Škodrić, S., Jovanović, M., Bogdanović, L., Bogdanović, R., Ležaić, V., Nesić, V.,& Dikman, S.. (2008). The significance of Goodpasture antigen in hereditary nephritis. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 282-286.
https://doi.org/10.2298/SARH08S4282B

Basta-Jovanović G, Radojević-Škodrić S, Jovanović M, Bogdanović L, Bogdanović R, Ležaić V, Nesić V, Dikman S. The significance of Goodpasture antigen in hereditary nephritis. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:282-286.
doi:10.2298/SARH08S4282B .

Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Jovanović, M., Bogdanović, L., Bogdanović, R., Ležaić, Višnja, Nesić, V., Dikman, S., "The significance of Goodpasture antigen in hereditary nephritis" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):282-286,
https://doi.org/10.2298/SARH08S4282B . .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, L.
AU  - Jovanović, M.
AU  - Baralić, I.
AU  - Savin, M.
AU  - Basta-Jovanović, Gordana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1392
AB  - INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Polycystic kidney disease--autopsy review from the period 1987-2007
VL  - 136 Suppl 4
SP  - 294
EP  - 297
DO  - 10.2298/SARH08S4294R
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Bogdanović, L. and Jovanović, M. and Baralić, I. and Savin, M. and Basta-Jovanović, Gordana",
year = "2008",
abstract = "INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Polycystic kidney disease--autopsy review from the period 1987-2007",
volume = "136 Suppl 4",
pages = "294-297",
doi = "10.2298/SARH08S4294R"
}

Radojević-Škodrić, S., Bogdanović, L., Jovanović, M., Baralić, I., Savin, M.,& Basta-Jovanović, G.. (2008). Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 294-297.
https://doi.org/10.2298/SARH08S4294R

Radojević-Škodrić S, Bogdanović L, Jovanović M, Baralić I, Savin M, Basta-Jovanović G. Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:294-297.
doi:10.2298/SARH08S4294R .

Radojević-Škodrić, Sanja, Bogdanović, L., Jovanović, M., Baralić, I., Savin, M., Basta-Jovanović, Gordana, "Polycystic kidney disease--autopsy review from the period 1987-2007" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):294-297,
https://doi.org/10.2298/SARH08S4294R . .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Đuricić, S.
AU  - Vučković, Mila
AU  - Dimitrijević, I.
AU  - Lazić, Miodrag
AU  - Stojšić, Z.
AU  - Brašanac, Dimitrije
AU  - Basta-Jovanović, Gordana
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1375
AB  - Abnormalities in cell cycle regulators and subsequent deregulation of G1-S transition may be one of the most important biological events in the malignant transformation of cells. The aim of this study was to investigate the expression of Cyclin E in the normal kidney, and in Wilms tumor, and to correlate the results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in lungs and one case of normal renal tissue. Correlation of semiquantitatively scored cyclin E levels with histopathological parameters was performed for all cases. Diffuse expression of cyclin E was more frequent in the blastemal (without epithelial component) then in the epithelial (without blastemal) component. This correlation showed high significance (p=0.001). Diffuse expression of cyclin E was more frequent in stage III/IV/V (71.4%) than in stage I/II (42.9%), showing no significant correlation (p>0.05). The intermediate risk group of Wilms tumor showed more frequent cyclin E diffuse expression (66.7%) in comparison with high risk cases (20%), showing statistical significance (p lt 0.05). Our findings suggest that diffuse expression of cyclin E is associated with the prognostic group and tumor stage. Also, cyclin E expression is more pronounced in the blastemal component than in the epithelial component.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria
T1  - Immunohistochemical analysis of cyclin E in Wilms tumors
VL  - 57
IS  - 5-6
SP  - 453
EP  - 464
DO  - 10.2298/AVB0706453R
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Đuricić, S. and Vučković, Mila and Dimitrijević, I. and Lazić, Miodrag and Stojšić, Z. and Brašanac, Dimitrije and Basta-Jovanović, Gordana",
year = "2007",
abstract = "Abnormalities in cell cycle regulators and subsequent deregulation of G1-S transition may be one of the most important biological events in the malignant transformation of cells. The aim of this study was to investigate the expression of Cyclin E in the normal kidney, and in Wilms tumor, and to correlate the results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in lungs and one case of normal renal tissue. Correlation of semiquantitatively scored cyclin E levels with histopathological parameters was performed for all cases. Diffuse expression of cyclin E was more frequent in the blastemal (without epithelial component) then in the epithelial (without blastemal) component. This correlation showed high significance (p=0.001). Diffuse expression of cyclin E was more frequent in stage III/IV/V (71.4%) than in stage I/II (42.9%), showing no significant correlation (p>0.05). The intermediate risk group of Wilms tumor showed more frequent cyclin E diffuse expression (66.7%) in comparison with high risk cases (20%), showing statistical significance (p lt 0.05). Our findings suggest that diffuse expression of cyclin E is associated with the prognostic group and tumor stage. Also, cyclin E expression is more pronounced in the blastemal component than in the epithelial component.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria",
title = "Immunohistochemical analysis of cyclin E in Wilms tumors",
volume = "57",
number = "5-6",
pages = "453-464",
doi = "10.2298/AVB0706453R"
}

Radojević-Škodrić, S., Đuricić, S., Vučković, M., Dimitrijević, I., Lazić, M., Stojšić, Z., Brašanac, D.,& Basta-Jovanović, G.. (2007). Immunohistochemical analysis of cyclin E in Wilms tumors. in Acta Veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 57(5-6), 453-464.
https://doi.org/10.2298/AVB0706453R

Radojević-Škodrić S, Đuricić S, Vučković M, Dimitrijević I, Lazić M, Stojšić Z, Brašanac D, Basta-Jovanović G. Immunohistochemical analysis of cyclin E in Wilms tumors. in Acta Veterinaria. 2007;57(5-6):453-464.
doi:10.2298/AVB0706453R .

Radojević-Škodrić, Sanja, Đuricić, S., Vučković, Mila, Dimitrijević, I., Lazić, Miodrag, Stojšić, Z., Brašanac, Dimitrije, Basta-Jovanović, Gordana, "Immunohistochemical analysis of cyclin E in Wilms tumors" in Acta Veterinaria, 57, no. 5-6 (2007):453-464,
https://doi.org/10.2298/AVB0706453R . .