TY  - CONF
AU  - Janović, Nataša
AU  - Janović, Aleksa
AU  - Pavlović, Bojan
AU  - Dimitrijević, Milovan
AU  - Đurić, Marija
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3299
PB  - Springer Nature
C3  - Insights into Imaging
T1  - Assessment of the internal nasal valve angle by computed tomography: a  new method proposal and a revision of current techniques
T1  - ECR 2020 Book of Abstracts
VL  - 11
IS  - Suppl 1
SP  - 545
EP  - 545
DO  - https://doi.org/10.1186/s13244-020-00851-0
ER  - 

@conference{
author = "Janović, Nataša and Janović, Aleksa and Pavlović, Bojan and Dimitrijević, Milovan and Đurić, Marija",
year = "2020",
publisher = "Springer Nature",
journal = "Insights into Imaging",
title = "Assessment of the internal nasal valve angle by computed tomography: a  new method proposal and a revision of current techniques, ECR 2020 Book of Abstracts",
volume = "11",
number = "Suppl 1",
pages = "545-545",
doi = "https://doi.org/10.1186/s13244-020-00851-0"
}

Janović, N., Janović, A., Pavlović, B., Dimitrijević, M.,& Đurić, M.. (2020). Assessment of the internal nasal valve angle by computed tomography: a  new method proposal and a revision of current techniques. in Insights into Imaging
Springer Nature., 11(Suppl 1), 545-545.
https://doi.org/https://doi.org/10.1186/s13244-020-00851-0

Janović N, Janović A, Pavlović B, Dimitrijević M, Đurić M. Assessment of the internal nasal valve angle by computed tomography: a  new method proposal and a revision of current techniques. in Insights into Imaging. 2020;11(Suppl 1):545-545.
doi:https://doi.org/10.1186/s13244-020-00851-0 .

Janović, Nataša, Janović, Aleksa, Pavlović, Bojan, Dimitrijević, Milovan, Đurić, Marija, "Assessment of the internal nasal valve angle by computed tomography: a  new method proposal and a revision of current techniques" in Insights into Imaging, 11, no. Suppl 1 (2020):545-545,
https://doi.org/https://doi.org/10.1186/s13244-020-00851-0 . .

TY  - JOUR
AU  - Ivošević, Tjasa
AU  - Miličić, Biljana
AU  - Dimitrijević, Milovan
AU  - Ivanović, Branislava
AU  - Pavlović, Aleksandar
AU  - Stojanović, Marina
AU  - Lakicević, Mirko
AU  - Stevanović, Ksenija
AU  - Kalezić, Nevena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2307
AB  - Intraoperative bradycardia (IOB) is one of the most common cardiac arrhythmias observed in clinical anaesthetic practice. Controlled hypotension, as a strategy of lowering patient's blood pressure during anesthesia has been practiced for decades in head and neck surgery. The aim of our study was to determine the incidence and the risk factors for intraoperative bradycardia in maxillofacial, ear, nose and throat surgery, as well as to determine whether controlled hypotension affects the occurrence of IOB. The retrospective study included 2304 patients who underwent maxillofacial, ear, nose or throat surgery. We studied the influence of: sex, age, comorbidity, type of surgery, duration of anesthesia and controlled hypotension on the occurrence of IOB. IOB was registered in 473 patients (20.5%). Patients with controlled hypotension had IOB significantly more often than patients without controlled hypotension (33.9 vs 15.1%) (p = 0.000). The significant predictors of IOB were: age (OR = 1.158; 95% CI = 1.068-1.256; p = 0.000), sex (OR = 0.786; 95% CI = 0.623-0.993; p = 0.043), ischemic heart disease (OR = 2.016; 95% CI = 1.182-3.441; p = 0.010); ear surgery (OR = 1.593; 95% CI = 1.232-2.060; p = 0.000), anesthesia duration, (OR = 1.006; 95% CI = 1.004-1.007; p = 0.000) and controlled hypotension (OR = 2.204; 95% CI = 1.761-2.758; p = 0.000). IOB is common in maxillofacial, ear, nose and throat surgery, particularly in male, older age and patients with ishemic heart disease. The ear surgery, longer anesthesia duration and controlled hypotension raise the risk for occurrence of IOB.
PB  - Springer, New York
T2  - European Archives of Oto-Rhino-Laryngology
T1  - Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery
VL  - 275
IS  - 2
SP  - 579
EP  - 586
DO  - 10.1007/s00405-017-4837-8
ER  - 

@article{
author = "Ivošević, Tjasa and Miličić, Biljana and Dimitrijević, Milovan and Ivanović, Branislava and Pavlović, Aleksandar and Stojanović, Marina and Lakicević, Mirko and Stevanović, Ksenija and Kalezić, Nevena",
year = "2018",
abstract = "Intraoperative bradycardia (IOB) is one of the most common cardiac arrhythmias observed in clinical anaesthetic practice. Controlled hypotension, as a strategy of lowering patient's blood pressure during anesthesia has been practiced for decades in head and neck surgery. The aim of our study was to determine the incidence and the risk factors for intraoperative bradycardia in maxillofacial, ear, nose and throat surgery, as well as to determine whether controlled hypotension affects the occurrence of IOB. The retrospective study included 2304 patients who underwent maxillofacial, ear, nose or throat surgery. We studied the influence of: sex, age, comorbidity, type of surgery, duration of anesthesia and controlled hypotension on the occurrence of IOB. IOB was registered in 473 patients (20.5%). Patients with controlled hypotension had IOB significantly more often than patients without controlled hypotension (33.9 vs 15.1%) (p = 0.000). The significant predictors of IOB were: age (OR = 1.158; 95% CI = 1.068-1.256; p = 0.000), sex (OR = 0.786; 95% CI = 0.623-0.993; p = 0.043), ischemic heart disease (OR = 2.016; 95% CI = 1.182-3.441; p = 0.010); ear surgery (OR = 1.593; 95% CI = 1.232-2.060; p = 0.000), anesthesia duration, (OR = 1.006; 95% CI = 1.004-1.007; p = 0.000) and controlled hypotension (OR = 2.204; 95% CI = 1.761-2.758; p = 0.000). IOB is common in maxillofacial, ear, nose and throat surgery, particularly in male, older age and patients with ishemic heart disease. The ear surgery, longer anesthesia duration and controlled hypotension raise the risk for occurrence of IOB.",
publisher = "Springer, New York",
journal = "European Archives of Oto-Rhino-Laryngology",
title = "Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery",
volume = "275",
number = "2",
pages = "579-586",
doi = "10.1007/s00405-017-4837-8"
}

Ivošević, T., Miličić, B., Dimitrijević, M., Ivanović, B., Pavlović, A., Stojanović, M., Lakicević, M., Stevanović, K.,& Kalezić, N.. (2018). Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery. in European Archives of Oto-Rhino-Laryngology
Springer, New York., 275(2), 579-586.
https://doi.org/10.1007/s00405-017-4837-8

Ivošević T, Miličić B, Dimitrijević M, Ivanović B, Pavlović A, Stojanović M, Lakicević M, Stevanović K, Kalezić N. Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery. in European Archives of Oto-Rhino-Laryngology. 2018;275(2):579-586.
doi:10.1007/s00405-017-4837-8 .

Ivošević, Tjasa, Miličić, Biljana, Dimitrijević, Milovan, Ivanović, Branislava, Pavlović, Aleksandar, Stojanović, Marina, Lakicević, Mirko, Stevanović, Ksenija, Kalezić, Nevena, "Risk factors for intraoperative bradycardia during ear, nose, throat and maxillofacial surgery" in European Archives of Oto-Rhino-Laryngology, 275, no. 2 (2018):579-586,
https://doi.org/10.1007/s00405-017-4837-8 . .

TY  - JOUR
AU  - Janović, Aleksa
AU  - Milovanović, Petar
AU  - Hahn, Michael
AU  - Rakočević, Zoran
AU  - Amling, Michael
AU  - Busse, Bjoern
AU  - Dimitrijević, Milovan
AU  - Đurić, Marija
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2183
AB  - Background/AimLe Fort lines have traditionally been considered as zones of weakness in the mid-facial skeleton although the structural basis of increased bone fragility at these sites has not yet been investigated. Considering recent findings of occlusal loading-related regional heterogeneity in the mid-facial bone micro-architecture, the aim of this study was to explore whether such heterogeneity in cortical and cancellous bone micro-architecture may contribute to increased fragility at Le Fort fracture sites. Materials and MethodsTwenty-five cortical and thirteen cancellous bone specimens were harvested from a dry skull and analyzed by micro-CT. Specimens were classified into Le Fort or Non-Le Fort groups based on their location in the mid-facial skeleton. ResultsCortical bone along Le Fort lines showed tendencies toward lower thickness (1.50.63 vs 1.75 +/- 0.79; P=.39) and greater porosity (11.48 +/- 5.67 vs 10.28 +/- 5.28; P=.59). A significant difference was detected in the trabecular degree of anisotropy which was higher in cancellous bone from Le Fort fracture sites (2.14 +/- 0.69 vs 1.58 +/- 0.34; P=.02). ConclusionsRegional heterogeneity in cortical bone micro-architecture could not fully explain increased fragility of the mid-facial skeleton at the Le Fort lines. However, regional differences in trabecular bone anisotropy may contribute to increased bone fragility.
PB  - Wiley, Hoboken
T2  - Dental Traumatology
T1  - Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines
VL  - 33
IS  - 4
SP  - 300
EP  - 306
DO  - 10.1111/edt.12333
ER  - 

@article{
author = "Janović, Aleksa and Milovanović, Petar and Hahn, Michael and Rakočević, Zoran and Amling, Michael and Busse, Bjoern and Dimitrijević, Milovan and Đurić, Marija",
year = "2017",
abstract = "Background/AimLe Fort lines have traditionally been considered as zones of weakness in the mid-facial skeleton although the structural basis of increased bone fragility at these sites has not yet been investigated. Considering recent findings of occlusal loading-related regional heterogeneity in the mid-facial bone micro-architecture, the aim of this study was to explore whether such heterogeneity in cortical and cancellous bone micro-architecture may contribute to increased fragility at Le Fort fracture sites. Materials and MethodsTwenty-five cortical and thirteen cancellous bone specimens were harvested from a dry skull and analyzed by micro-CT. Specimens were classified into Le Fort or Non-Le Fort groups based on their location in the mid-facial skeleton. ResultsCortical bone along Le Fort lines showed tendencies toward lower thickness (1.50.63 vs 1.75 +/- 0.79; P=.39) and greater porosity (11.48 +/- 5.67 vs 10.28 +/- 5.28; P=.59). A significant difference was detected in the trabecular degree of anisotropy which was higher in cancellous bone from Le Fort fracture sites (2.14 +/- 0.69 vs 1.58 +/- 0.34; P=.02). ConclusionsRegional heterogeneity in cortical bone micro-architecture could not fully explain increased fragility of the mid-facial skeleton at the Le Fort lines. However, regional differences in trabecular bone anisotropy may contribute to increased bone fragility.",
publisher = "Wiley, Hoboken",
journal = "Dental Traumatology",
title = "Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines",
volume = "33",
number = "4",
pages = "300-306",
doi = "10.1111/edt.12333"
}

Janović, A., Milovanović, P., Hahn, M., Rakočević, Z., Amling, M., Busse, B., Dimitrijević, M.,& Đurić, M.. (2017). Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines. in Dental Traumatology
Wiley, Hoboken., 33(4), 300-306.
https://doi.org/10.1111/edt.12333

Janović A, Milovanović P, Hahn M, Rakočević Z, Amling M, Busse B, Dimitrijević M, Đurić M. Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines. in Dental Traumatology. 2017;33(4):300-306.
doi:10.1111/edt.12333 .

Janović, Aleksa, Milovanović, Petar, Hahn, Michael, Rakočević, Zoran, Amling, Michael, Busse, Bjoern, Dimitrijević, Milovan, Đurić, Marija, "Association between regional heterogeneity in the mid-facial bone micro-architecture and increased fragility along Le Fort lines" in Dental Traumatology, 33, no. 4 (2017):300-306,
https://doi.org/10.1111/edt.12333 . .

TY  - JOUR
AU  - Radunović, Milena
AU  - Nikolić, Nadja
AU  - Milenković, Sanja
AU  - Tomanović, Nada
AU  - Boričić, Ivan
AU  - Dimitrijević, Milovan
AU  - Novaković, Ivana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2178
AB  - Purpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer
VL  - 21
IS  - 3
SP  - 597
EP  - 602
UR  - https://hdl.handle.net/21.15107/rcub_smile_2178
ER  - 

@article{
author = "Radunović, Milena and Nikolić, Nadja and Milenković, Sanja and Tomanović, Nada and Boričić, Ivan and Dimitrijević, Milovan and Novaković, Ivana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer",
volume = "21",
number = "3",
pages = "597-602",
url = "https://hdl.handle.net/21.15107/rcub_smile_2178"
}

Radunović, M., Nikolić, N., Milenković, S., Tomanović, N., Boričić, I., Dimitrijević, M., Novaković, I.,& Basta-Jovanović, G.. (2016). The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(3), 597-602.
https://hdl.handle.net/21.15107/rcub_smile_2178

Radunović M, Nikolić N, Milenković S, Tomanović N, Boričić I, Dimitrijević M, Novaković I, Basta-Jovanović G. The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer. in Journal of BUON. 2016;21(3):597-602.
https://hdl.handle.net/21.15107/rcub_smile_2178 .

Radunović, Milena, Nikolić, Nadja, Milenković, Sanja, Tomanović, Nada, Boričić, Ivan, Dimitrijević, Milovan, Novaković, Ivana, Basta-Jovanović, Gordana, "The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer" in Journal of BUON, 21, no. 3 (2016):597-602,
https://hdl.handle.net/21.15107/rcub_smile_2178 .

TY  - JOUR
AU  - Radunović, Milena
AU  - Tomanović, Nada
AU  - Novaković, Ivana
AU  - Boričić, Ivan
AU  - Milenković, Sanja
AU  - Dimitrijević, Milovan
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, Ljiljana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2077
AB  - Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer
VL  - 21
IS  - 6
SP  - 1530
EP  - 1536
UR  - https://hdl.handle.net/21.15107/rcub_smile_2077
ER  - 

@article{
author = "Radunović, Milena and Tomanović, Nada and Novaković, Ivana and Boričić, Ivan and Milenković, Sanja and Dimitrijević, Milovan and Radojević-Škodrić, Sanja and Bogdanović, Ljiljana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer",
volume = "21",
number = "6",
pages = "1530-1536",
url = "https://hdl.handle.net/21.15107/rcub_smile_2077"
}

Radunović, M., Tomanović, N., Novaković, I., Boričić, I., Milenković, S., Dimitrijević, M., Radojević-Škodrić, S., Bogdanović, L.,& Basta-Jovanović, G.. (2016). Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(6), 1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077

Radunović M, Tomanović N, Novaković I, Boričić I, Milenković S, Dimitrijević M, Radojević-Škodrić S, Bogdanović L, Basta-Jovanović G. Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON. 2016;21(6):1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077 .

Radunović, Milena, Tomanović, Nada, Novaković, Ivana, Boričić, Ivan, Milenković, Sanja, Dimitrijević, Milovan, Radojević-Škodrić, Sanja, Bogdanović, Ljiljana, Basta-Jovanović, Gordana, "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer" in Journal of BUON, 21, no. 6 (2016):1530-1536,
https://hdl.handle.net/21.15107/rcub_smile_2077 .

TY  - JOUR
AU  - Brinkmann, Ole
AU  - Kastratović, Dragana A.
AU  - Dimitrijević, Milovan
AU  - Konstantinović, Vitomir
AU  - Jelovac, Drago
AU  - Antić, Jadranka
AU  - Nesić, Vladimir S.
AU  - Marković, Srđan Z.
AU  - Martinović, Željko
AU  - Akin, David
AU  - Spielmann, Nadine
AU  - Zhou, Hui
AU  - Wong, David T.
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1608
AB  - Early detection of oral squamous cell cancer (OSCC) is the key to improve the low 5-year survival rate. Using proteomic and genomic technologies we have previously discovered and validated salivary OSCC markers in American patients. The question arises whether these biomarkers are discriminatory in cohorts of different ethnic background. Six transcriptome (DUSP1, IL8, IL1B, OAZ1, SAT1, and S100P) and three proteome (IL1B, IL8, and M2BP) biomarkers were tested on 18 early and 17 late stage OSCC patients and 51 healthy controls with quantitative PCR and ELISA. Four transcriptome (IL8, IL1B, SAT1, and S100P) and all proteome biomarkers were significantly elevated (p  lt  0.05) in OSCC patients. The combination of markers yielded an AUC of 0.86, 0.85 and 0.88 for OSCC total, T1-T2, and T3-T4, respectively. The sensitivity/specificity for OSCC total was 0.89/0.78, for T1-T2 0.67/0.96, and for T3-T4 0.82/0.84. In conclusion, seven of the nine salivary biomarkers (three proteins and four mRNAs) were validated and performed strongest in late stage cancer. Patient-based salivary diagnostics is a highly promising approach for OSCC detection. This study shows that previously discovered and validated salivary OSCC biomarkers are discriminatory and reproducible in a different ethnic cohort. These findings support the feasibility to implement multi-center, multi-ethnicity clinical trials towards the pivotal validation of salivary biomarkers for OSCC detection.
PB  - Elsevier Science Bv, Amsterdam
T2  - Oral Oncology
T1  - Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population
VL  - 47
IS  - 1
SP  - 51
EP  - 55
DO  - 10.1016/j.oraloncology.2010.10.009
ER  - 

@article{
author = "Brinkmann, Ole and Kastratović, Dragana A. and Dimitrijević, Milovan and Konstantinović, Vitomir and Jelovac, Drago and Antić, Jadranka and Nesić, Vladimir S. and Marković, Srđan Z. and Martinović, Željko and Akin, David and Spielmann, Nadine and Zhou, Hui and Wong, David T.",
year = "2011",
abstract = "Early detection of oral squamous cell cancer (OSCC) is the key to improve the low 5-year survival rate. Using proteomic and genomic technologies we have previously discovered and validated salivary OSCC markers in American patients. The question arises whether these biomarkers are discriminatory in cohorts of different ethnic background. Six transcriptome (DUSP1, IL8, IL1B, OAZ1, SAT1, and S100P) and three proteome (IL1B, IL8, and M2BP) biomarkers were tested on 18 early and 17 late stage OSCC patients and 51 healthy controls with quantitative PCR and ELISA. Four transcriptome (IL8, IL1B, SAT1, and S100P) and all proteome biomarkers were significantly elevated (p  lt  0.05) in OSCC patients. The combination of markers yielded an AUC of 0.86, 0.85 and 0.88 for OSCC total, T1-T2, and T3-T4, respectively. The sensitivity/specificity for OSCC total was 0.89/0.78, for T1-T2 0.67/0.96, and for T3-T4 0.82/0.84. In conclusion, seven of the nine salivary biomarkers (three proteins and four mRNAs) were validated and performed strongest in late stage cancer. Patient-based salivary diagnostics is a highly promising approach for OSCC detection. This study shows that previously discovered and validated salivary OSCC biomarkers are discriminatory and reproducible in a different ethnic cohort. These findings support the feasibility to implement multi-center, multi-ethnicity clinical trials towards the pivotal validation of salivary biomarkers for OSCC detection.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Oral Oncology",
title = "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population",
volume = "47",
number = "1",
pages = "51-55",
doi = "10.1016/j.oraloncology.2010.10.009"
}

Brinkmann, O., Kastratović, D. A., Dimitrijević, M., Konstantinović, V., Jelovac, D., Antić, J., Nesić, V. S., Marković, S. Z., Martinović, Ž., Akin, D., Spielmann, N., Zhou, H.,& Wong, D. T.. (2011). Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. in Oral Oncology
Elsevier Science Bv, Amsterdam., 47(1), 51-55.
https://doi.org/10.1016/j.oraloncology.2010.10.009

Brinkmann O, Kastratović DA, Dimitrijević M, Konstantinović V, Jelovac D, Antić J, Nesić VS, Marković SZ, Martinović Ž, Akin D, Spielmann N, Zhou H, Wong DT. Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population. in Oral Oncology. 2011;47(1):51-55.
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Brinkmann, Ole, Kastratović, Dragana A., Dimitrijević, Milovan, Konstantinović, Vitomir, Jelovac, Drago, Antić, Jadranka, Nesić, Vladimir S., Marković, Srđan Z., Martinović, Željko, Akin, David, Spielmann, Nadine, Zhou, Hui, Wong, David T., "Oral squamous cell carcinoma detection by salivary biomarkers in a Serbian population" in Oral Oncology, 47, no. 1 (2011):51-55,
https://doi.org/10.1016/j.oraloncology.2010.10.009 . .