Jovanović, M.

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Biocompatibility of a new nanomaterial based on calcium silicate implanted in subcutaneous connective tissue of rats

Petrović, Violeta; Opačić-Galić, Vanja; Jokanović, Vukoman; Jovanović, M.; Basta-Jovanović, Gordana; Živković, Slavoljub

(Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd, 2012)

TY  - JOUR
AU  - Petrović, Violeta
AU  - Opačić-Galić, Vanja
AU  - Jokanović, Vukoman
AU  - Jovanović, M.
AU  - Basta-Jovanović, Gordana
AU  - Živković, Slavoljub
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1708
AB  - The aim of the study was to investigate rat connective tissue response to a new calcium silicate system 7, 15, 30 and 60 days after implantation. Twenty Wistar albino male rats received two tubes half-filled with a new calcium silicate system (NCSS) or MTA in subcutaneous tissue. The empty half of the tubes served as controls. Five animals were sacrificed after 7, 15, 30 and 60 days and samples of the subcutaneous tissue around implanted material were submitted to histological analysis. The intensity of inflammation was evaluated based on the number of inflammatory cells present. Statistical analysis was performed using one way ANOVA and Holm Sidak's multiple comparison tests. Mild to moderate inflammatory reaction was observed after 7, 15 and 30 days around a NCSS while mild inflammatory reaction was detected after 60 days of implantation. In the MTA group, mild to moderate inflammatory reaction was found after 7 and 15 days while mild inflammatory reaction was present after 30 and 60 days. There was no statistically significant difference in the intensity of inflammatory reactions between the tested materials and control groups in any experimental period (ANOVA p>0.05). Regarding the intensity of inflammatory reactions at different experimental periods, a statistically significant difference was observed between 7 and 30 days, 7 and 60 days and 15 to 60 days for both materials. For the controls, a statistically significant difference was found between 7 and 60 days and 15 and 60 days of the experiment (Holm Sidak  lt  p 0.001). Subcutaneous tissue of rats showed good tolerance to a new calcium silicate system. Inflammatory reaction was similar to that caused by MTA.
AB  - Cilj ovog rada je bio da se ispita biokompatibilnost novog kalcijum silikatnog sistema nakon in vivo implantacije u potkožno tkivo pacova. Istraživanje je obuhvatilo 20 Wistar albino pacova muškog pola. U svaku životinju implantirane su dve tube do pola ispunjene novim kalcijum silikatnim sistemom (NCSS) odnosno MTA-om. Prazne polovine tuba služile su kao kontrola. Po 5 životinja žrtvovano je nakon 7, 15, 30 i 60 dana, nakon čega su uzorci potkožnog tkiva oko implantiranog materijala pripremljeni za histološku analizu. Intezitet zapaljenske reakcije je procenjivan na osnovu broja prisutnih ćelija zapaljenja. Statistička analiza je urađena ANOVA testom i Holm Sidak-ovim testom višestruke komparacije. U eksperimentalnim periodima 7, 15 i 30 dana u NCSS grupi je uočena blaga do umerena zapaljenska reakcija, a nakon 60 dana samo blaga zapaljenska reakcija. UMTA grupi, nakon 7 i 15 dana uočena je blaga do umerena zapaljenska reakcija, a nakon 30 i 60 dana blaga zapaljenska reakcija. Nije bilo statistički značajne razlike u intezitetu zapaljenske reakcije između testiranih materijala i kontrolne grupe ni u jednom eksperimentalnom periodu (ANOVA p>0.05). Poređenjem inteziteta zapaljenskih reakcija u različitim eksperimentalnim periodima, uočeno je postojanje statistički značajnih razlika kod oba testirana materijala između 7 i 30 dana, 7 i 60 dana kao i između 15 i 60 dana, a kod kontrole između 7 i 60 dana i 15 i 60 dana eksperimenta (Holm Sidak p  lt  0.001). Novi kalcijum silikatni sistem je pokazao biokompatibilno ponašanje. Inflamatorne reakcije potkožnog tkiva bile su slične onima koje je izazvao MTA.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Biocompatibility of a new nanomaterial based on calcium silicate implanted in subcutaneous connective tissue of rats
T1  - Ispitivanje biokompatibilnosti novog nanostrukturalnog materijala na bazi kalcijum silikatnih sistema implantiranjem u potkožno tkivo pacova
VL  - 62
IS  - 5-6
SP  - 697
EP  - 708
DO  - 10.2298/AVB1206697P
ER  - 
@article{
author = "Petrović, Violeta and Opačić-Galić, Vanja and Jokanović, Vukoman and Jovanović, M. and Basta-Jovanović, Gordana and Živković, Slavoljub",
year = "2012",
abstract = "The aim of the study was to investigate rat connective tissue response to a new calcium silicate system 7, 15, 30 and 60 days after implantation. Twenty Wistar albino male rats received two tubes half-filled with a new calcium silicate system (NCSS) or MTA in subcutaneous tissue. The empty half of the tubes served as controls. Five animals were sacrificed after 7, 15, 30 and 60 days and samples of the subcutaneous tissue around implanted material were submitted to histological analysis. The intensity of inflammation was evaluated based on the number of inflammatory cells present. Statistical analysis was performed using one way ANOVA and Holm Sidak's multiple comparison tests. Mild to moderate inflammatory reaction was observed after 7, 15 and 30 days around a NCSS while mild inflammatory reaction was detected after 60 days of implantation. In the MTA group, mild to moderate inflammatory reaction was found after 7 and 15 days while mild inflammatory reaction was present after 30 and 60 days. There was no statistically significant difference in the intensity of inflammatory reactions between the tested materials and control groups in any experimental period (ANOVA p>0.05). Regarding the intensity of inflammatory reactions at different experimental periods, a statistically significant difference was observed between 7 and 30 days, 7 and 60 days and 15 to 60 days for both materials. For the controls, a statistically significant difference was found between 7 and 60 days and 15 and 60 days of the experiment (Holm Sidak  lt  p 0.001). Subcutaneous tissue of rats showed good tolerance to a new calcium silicate system. Inflammatory reaction was similar to that caused by MTA., Cilj ovog rada je bio da se ispita biokompatibilnost novog kalcijum silikatnog sistema nakon in vivo implantacije u potkožno tkivo pacova. Istraživanje je obuhvatilo 20 Wistar albino pacova muškog pola. U svaku životinju implantirane su dve tube do pola ispunjene novim kalcijum silikatnim sistemom (NCSS) odnosno MTA-om. Prazne polovine tuba služile su kao kontrola. Po 5 životinja žrtvovano je nakon 7, 15, 30 i 60 dana, nakon čega su uzorci potkožnog tkiva oko implantiranog materijala pripremljeni za histološku analizu. Intezitet zapaljenske reakcije je procenjivan na osnovu broja prisutnih ćelija zapaljenja. Statistička analiza je urađena ANOVA testom i Holm Sidak-ovim testom višestruke komparacije. U eksperimentalnim periodima 7, 15 i 30 dana u NCSS grupi je uočena blaga do umerena zapaljenska reakcija, a nakon 60 dana samo blaga zapaljenska reakcija. UMTA grupi, nakon 7 i 15 dana uočena je blaga do umerena zapaljenska reakcija, a nakon 30 i 60 dana blaga zapaljenska reakcija. Nije bilo statistički značajne razlike u intezitetu zapaljenske reakcije između testiranih materijala i kontrolne grupe ni u jednom eksperimentalnom periodu (ANOVA p>0.05). Poređenjem inteziteta zapaljenskih reakcija u različitim eksperimentalnim periodima, uočeno je postojanje statistički značajnih razlika kod oba testirana materijala između 7 i 30 dana, 7 i 60 dana kao i između 15 i 60 dana, a kod kontrole između 7 i 60 dana i 15 i 60 dana eksperimenta (Holm Sidak p  lt  0.001). Novi kalcijum silikatni sistem je pokazao biokompatibilno ponašanje. Inflamatorne reakcije potkožnog tkiva bile su slične onima koje je izazvao MTA.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Biocompatibility of a new nanomaterial based on calcium silicate implanted in subcutaneous connective tissue of rats, Ispitivanje biokompatibilnosti novog nanostrukturalnog materijala na bazi kalcijum silikatnih sistema implantiranjem u potkožno tkivo pacova",
volume = "62",
number = "5-6",
pages = "697-708",
doi = "10.2298/AVB1206697P"
}
Petrović, V., Opačić-Galić, V., Jokanović, V., Jovanović, M., Basta-Jovanović, G.,& Živković, S.. (2012). Biocompatibility of a new nanomaterial based on calcium silicate implanted in subcutaneous connective tissue of rats. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 62(5-6), 697-708.
https://doi.org/10.2298/AVB1206697P
Petrović V, Opačić-Galić V, Jokanović V, Jovanović M, Basta-Jovanović G, Živković S. Biocompatibility of a new nanomaterial based on calcium silicate implanted in subcutaneous connective tissue of rats. in Acta veterinaria. 2012;62(5-6):697-708.
doi:10.2298/AVB1206697P .
Petrović, Violeta, Opačić-Galić, Vanja, Jokanović, Vukoman, Jovanović, M., Basta-Jovanović, Gordana, Živković, Slavoljub, "Biocompatibility of a new nanomaterial based on calcium silicate implanted in subcutaneous connective tissue of rats" in Acta veterinaria, 62, no. 5-6 (2012):697-708,
https://doi.org/10.2298/AVB1206697P . .
7
6
6

Prognostic value of survivin expression in Wilms tumor

Basta-Jovanović, Gordana; Radojević-Škodrić, Sanja; Brašanac, Dimitrije; Đuricić, S.; Milašin, Jelena; Bogdanović, L.; Oprić, D.; Savin, M.; Baralić, I.; Jovanović, M.

(Balkan Union of Oncology (B.U.ON.), 2012)

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuricić, S.
AU  - Milašin, Jelena
AU  - Bogdanović, L.
AU  - Oprić, D.
AU  - Savin, M.
AU  - Baralić, I.
AU  - Jovanović, M.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1747
AB  - Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Prognostic value of survivin expression in Wilms tumor
VL  - 17
IS  - 1
SP  - 168
EP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_smile_1747
ER  - 
@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuricić, S. and Milašin, Jelena and Bogdanović, L. and Oprić, D. and Savin, M. and Baralić, I. and Jovanović, M.",
year = "2012",
abstract = "Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Prognostic value of survivin expression in Wilms tumor",
volume = "17",
number = "1",
pages = "168-173",
url = "https://hdl.handle.net/21.15107/rcub_smile_1747"
}
Basta-Jovanović, G., Radojević-Škodrić, S., Brašanac, D., Đuricić, S., Milašin, J., Bogdanović, L., Oprić, D., Savin, M., Baralić, I.,& Jovanović, M.. (2012). Prognostic value of survivin expression in Wilms tumor. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747
Basta-Jovanović G, Radojević-Škodrić S, Brašanac D, Đuricić S, Milašin J, Bogdanović L, Oprić D, Savin M, Baralić I, Jovanović M. Prognostic value of survivin expression in Wilms tumor. in Journal of BUON. 2012;17(1):168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747 .
Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Brašanac, Dimitrije, Đuricić, S., Milašin, Jelena, Bogdanović, L., Oprić, D., Savin, M., Baralić, I., Jovanović, M., "Prognostic value of survivin expression in Wilms tumor" in Journal of BUON, 17, no. 1 (2012):168-173,
https://hdl.handle.net/21.15107/rcub_smile_1747 .
6

The significance of Goodpasture antigen in hereditary nephritis

Basta-Jovanović, Gordana; Radojević-Škodrić, Sanja; Jovanović, M.; Bogdanović, L.; Bogdanović, R.; Ležaić, Višnja; Nesić, V.; Dikman, S.

(Srpsko lekarsko društvo, Beograd, 2008)

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Jovanović, M.
AU  - Bogdanović, L.
AU  - Bogdanović, R.
AU  - Ležaić, Višnja
AU  - Nesić, V.
AU  - Dikman, S.
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1393
AB  - INTRODUCTION: Two types of hereditary nephritis, nonprogressive and progressive, clinically present as asymptomatic haematuria, sometimes combined with proteinuria. At the onset, in both types, light microscopic changes are minimal, immunofluorescence findings are negative, and diagnosis can be made only upon electron microscopic findings that are considered to be specific. OBJECTIVE: The aim of this study was to determine the significance of Goodpasture antigen detection in diagnosis of progressive and nonprogressive hereditary nephritis in its early phase. METHOD: Analysis of renal biopsy specimens was done in patients with hereditary nephritis that were followed from 1990 to 2005. Progression of renal disease was examined in 14 patients with Alport's syndrome, 10 patients with thin basement membrane disease, and 6 patients with unclassified hereditary nephritis diagnosed. For all these cases, indirect immunofluorescence study with serum from a patient with high titer of Goodpasture autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane was performed. RESULTS: In 11 out of 14 cases diagnosed as Alport's syndrome, there was negative staining with Goodpasture serum, and in 3 additional cases with Alport's syndrome, expression of Goodpasture antigen in glomerular basement membrane and thin basement membrane was highly reduced. In all 10 patients with thin basement membrane disease, immunofluorescence showed intensive, bright linear staining with Goodpasture serum along glomerular and tubular basement membrane. In 2 out of 6 patients with unclassified hereditary nephritis, Goodpasture antigen expression was very strong, in one patient it was very reduced, and in 3 patients it was negative. CONCLUSION: The results of our study show that Goodpasture antigen detection plays a very important role in differential diagnosis of progressive and nonpregressive hereditary nephritis, particularly in early phases of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The significance of Goodpasture antigen in hereditary nephritis
VL  - 136 Suppl 4
SP  - 282
EP  - 286
DO  - 10.2298/SARH08S4282B
ER  - 
@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Jovanović, M. and Bogdanović, L. and Bogdanović, R. and Ležaić, Višnja and Nesić, V. and Dikman, S.",
year = "2008",
abstract = "INTRODUCTION: Two types of hereditary nephritis, nonprogressive and progressive, clinically present as asymptomatic haematuria, sometimes combined with proteinuria. At the onset, in both types, light microscopic changes are minimal, immunofluorescence findings are negative, and diagnosis can be made only upon electron microscopic findings that are considered to be specific. OBJECTIVE: The aim of this study was to determine the significance of Goodpasture antigen detection in diagnosis of progressive and nonprogressive hereditary nephritis in its early phase. METHOD: Analysis of renal biopsy specimens was done in patients with hereditary nephritis that were followed from 1990 to 2005. Progression of renal disease was examined in 14 patients with Alport's syndrome, 10 patients with thin basement membrane disease, and 6 patients with unclassified hereditary nephritis diagnosed. For all these cases, indirect immunofluorescence study with serum from a patient with high titer of Goodpasture autoantibodies that recognize the antigenic determinants in human glomerular and tubular basement membrane was performed. RESULTS: In 11 out of 14 cases diagnosed as Alport's syndrome, there was negative staining with Goodpasture serum, and in 3 additional cases with Alport's syndrome, expression of Goodpasture antigen in glomerular basement membrane and thin basement membrane was highly reduced. In all 10 patients with thin basement membrane disease, immunofluorescence showed intensive, bright linear staining with Goodpasture serum along glomerular and tubular basement membrane. In 2 out of 6 patients with unclassified hereditary nephritis, Goodpasture antigen expression was very strong, in one patient it was very reduced, and in 3 patients it was negative. CONCLUSION: The results of our study show that Goodpasture antigen detection plays a very important role in differential diagnosis of progressive and nonpregressive hereditary nephritis, particularly in early phases of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The significance of Goodpasture antigen in hereditary nephritis",
volume = "136 Suppl 4",
pages = "282-286",
doi = "10.2298/SARH08S4282B"
}
Basta-Jovanović, G., Radojević-Škodrić, S., Jovanović, M., Bogdanović, L., Bogdanović, R., Ležaić, V., Nesić, V.,& Dikman, S.. (2008). The significance of Goodpasture antigen in hereditary nephritis. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 282-286.
https://doi.org/10.2298/SARH08S4282B
Basta-Jovanović G, Radojević-Škodrić S, Jovanović M, Bogdanović L, Bogdanović R, Ležaić V, Nesić V, Dikman S. The significance of Goodpasture antigen in hereditary nephritis. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:282-286.
doi:10.2298/SARH08S4282B .
Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Jovanović, M., Bogdanović, L., Bogdanović, R., Ležaić, Višnja, Nesić, V., Dikman, S., "The significance of Goodpasture antigen in hereditary nephritis" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):282-286,
https://doi.org/10.2298/SARH08S4282B . .

Polycystic kidney disease--autopsy review from the period 1987-2007

Radojević-Škodrić, Sanja; Bogdanović, L.; Jovanović, M.; Baralić, I.; Savin, M.; Basta-Jovanović, Gordana

(Srpsko lekarsko društvo, Beograd, 2008)

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, L.
AU  - Jovanović, M.
AU  - Baralić, I.
AU  - Savin, M.
AU  - Basta-Jovanović, Gordana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1392
AB  - INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Polycystic kidney disease--autopsy review from the period 1987-2007
VL  - 136 Suppl 4
SP  - 294
EP  - 297
DO  - 10.2298/SARH08S4294R
ER  - 
@article{
author = "Radojević-Škodrić, Sanja and Bogdanović, L. and Jovanović, M. and Baralić, I. and Savin, M. and Basta-Jovanović, Gordana",
year = "2008",
abstract = "INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Polycystic kidney disease--autopsy review from the period 1987-2007",
volume = "136 Suppl 4",
pages = "294-297",
doi = "10.2298/SARH08S4294R"
}
Radojević-Škodrić, S., Bogdanović, L., Jovanović, M., Baralić, I., Savin, M.,& Basta-Jovanović, G.. (2008). Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 294-297.
https://doi.org/10.2298/SARH08S4294R
Radojević-Škodrić S, Bogdanović L, Jovanović M, Baralić I, Savin M, Basta-Jovanović G. Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:294-297.
doi:10.2298/SARH08S4294R .
Radojević-Škodrić, Sanja, Bogdanović, L., Jovanović, M., Baralić, I., Savin, M., Basta-Jovanović, Gordana, "Polycystic kidney disease--autopsy review from the period 1987-2007" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):294-297,
https://doi.org/10.2298/SARH08S4294R . .