TY  - JOUR
AU  - Milošević-Marković, Maja
AU  - Lazarević, Miloš
AU  - Toljić, Boško
AU  - Petrović, Milan
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Jelovac, Drago
AU  - Jovanović, Svetlana
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3283
AB  - Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.
PB  - TECH SCIENCE PRESS
T2  - BIOCELL
T1  - Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential
VL  - 45
IS  - 6
SP  - 1543
EP  - 1550
DO  - 10.32604/biocell.2021.015060
ER  - 

@article{
author = "Milošević-Marković, Maja and Lazarević, Miloš and Toljić, Boško and Petrović, Milan and Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Jelovac, Drago and Jovanović, Svetlana and Milašin, Jelena",
year = "2021",
abstract = "Specific cell subpopulations identified as cancer stem cells (CSCs) can be found in basal cell carcinoma (BCC).
Generally, CSCs have a marked trans-differentiation potential that could potentially be used in differentiation therapies.
However, there are no studies regarding BCC CSCs multipotency. The aim of the study was to analyze the characteristic of
CSCs of BCC with emphasis on their differentiation potential upon specific induction. Specific staining and cell
morphology were used for differentiation confirmation, along with the expression analysis of osteogenic (ALP, BSP,
Runx2, OCN, BMP2), chondrogenic (COL1 and COL2A1), adipogenic (PPAR-γ) and neurogenic (Nestin and MAP2)
markers. BCC CSCs differentiated into osteogenic and chondrogenic lineages, as judged by staining and high
expression of specific markers (from 2-to 92-fold higher upon induction). Concomitantly with differentiation, the
levels of cancer stem cell markers decreased in the cultures. Adipo-differentiation and neuro-differentiation were
unsuccessful. In conclusion, BCC CSCs exhibit the capacity to trans-differentiate, a characteristic that may potentially
be useful in the development of new strategies for the treatment of aggressive BCCs.",
publisher = "TECH SCIENCE PRESS",
journal = "BIOCELL",
title = "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential",
volume = "45",
number = "6",
pages = "1543-1550",
doi = "10.32604/biocell.2021.015060"
}

Milošević-Marković, M., Lazarević, M., Toljić, B., Petrović, M., Vukadinović, M., Jezdić, Z., Aničić, B., Jelovac, D., Jovanović, S.,& Milašin, J.. (2021). Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL
TECH SCIENCE PRESS., 45(6), 1543-1550.
https://doi.org/10.32604/biocell.2021.015060

Milošević-Marković M, Lazarević M, Toljić B, Petrović M, Vukadinović M, Jezdić Z, Aničić B, Jelovac D, Jovanović S, Milašin J. Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential. in BIOCELL. 2021;45(6):1543-1550.
doi:10.32604/biocell.2021.015060 .

Milošević-Marković, Maja, Lazarević, Miloš, Toljić, Boško, Petrović, Milan, Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Jelovac, Drago, Jovanović, Svetlana, Milašin, Jelena, "Basal cell carcinoma stem cells exhibit osteogenic and chondrogenic differentiation potential" in BIOCELL, 45, no. 6 (2021):1543-1550,
https://doi.org/10.32604/biocell.2021.015060 . .

TY  - JOUR
AU  - Vučković, Mila
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
AU  - Đorđević, Vladan
AU  - Milinković, Iva
AU  - Asotić, Jasminka
AU  - Jezdić, Zoran
AU  - Janković, Saša
AU  - Aleksić, Zoran
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2525
AB  - Introduction/Objective. The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments of chronic periodontitis [scaling and root planning (SRP)] alone and SRP in conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods. Twenty-four patients with chronic periodontitis who had at least two sites with probing pocket depth (PPD) ≥ 5 mm on contralateral side participated in the study. Using a split-mouth design, the patients were treated with SRP + I-PRF (study group) or SRP only (control group). The clinical parameters, clinical attachment level (CAL), gingival margin level (GML), PPD, bleeding on probing, and plaque index, were recorded on both sides. Results. Compared to baseline, both treatment modalities demonstrated an improvement in investigated clinical parameters. The mean value of CAL was reduced from 1.97 ± 0.75 (0.25–3.31) to 1.07 ± 0.44 (0.12–1.78) in the study group, whereas it decreased from 1.81 ± 0.66 (0.42–2.96) to 1.48 ± 0.55 (0.22–2.30) in the control group. Similarly, the corresponding values for GML and PPD showed statistically significant difference between the groups (p = 0.040 and p = 0.006, respectively). Conclusion. Regardless the limited number of patients in the study, initial periodontal therapy in conjunction with injectable platelet-rich fibrin proved to display significant improvement in all clinical parameters compared to initial periodontal therapy alone.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis
VL  - 148
IS  - 5-6
SP  - 280
EP  - 285
DO  - 10.2298/SARH190925022V
ER  - 

@article{
author = "Vučković, Mila and Nikolić, Nadja and Milašin, Jelena and Đorđević, Vladan and Milinković, Iva and Asotić, Jasminka and Jezdić, Zoran and Janković, Saša and Aleksić, Zoran",
year = "2020",
abstract = "Introduction/Objective. The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments of chronic periodontitis [scaling and root planning (SRP)] alone and SRP in conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods. Twenty-four patients with chronic periodontitis who had at least two sites with probing pocket depth (PPD) ≥ 5 mm on contralateral side participated in the study. Using a split-mouth design, the patients were treated with SRP + I-PRF (study group) or SRP only (control group). The clinical parameters, clinical attachment level (CAL), gingival margin level (GML), PPD, bleeding on probing, and plaque index, were recorded on both sides. Results. Compared to baseline, both treatment modalities demonstrated an improvement in investigated clinical parameters. The mean value of CAL was reduced from 1.97 ± 0.75 (0.25–3.31) to 1.07 ± 0.44 (0.12–1.78) in the study group, whereas it decreased from 1.81 ± 0.66 (0.42–2.96) to 1.48 ± 0.55 (0.22–2.30) in the control group. Similarly, the corresponding values for GML and PPD showed statistically significant difference between the groups (p = 0.040 and p = 0.006, respectively). Conclusion. Regardless the limited number of patients in the study, initial periodontal therapy in conjunction with injectable platelet-rich fibrin proved to display significant improvement in all clinical parameters compared to initial periodontal therapy alone.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis",
volume = "148",
number = "5-6",
pages = "280-285",
doi = "10.2298/SARH190925022V"
}

Vučković, M., Nikolić, N., Milašin, J., Đorđević, V., Milinković, I., Asotić, J., Jezdić, Z., Janković, S.,& Aleksić, Z.. (2020). The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 148(5-6), 280-285.
https://doi.org/10.2298/SARH190925022V

Vučković M, Nikolić N, Milašin J, Đorđević V, Milinković I, Asotić J, Jezdić Z, Janković S, Aleksić Z. The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis. in Srpski arhiv za celokupno lekarstvo. 2020;148(5-6):280-285.
doi:10.2298/SARH190925022V .

Vučković, Mila, Nikolić, Nadja, Milašin, Jelena, Đorđević, Vladan, Milinković, Iva, Asotić, Jasminka, Jezdić, Zoran, Janković, Saša, Aleksić, Zoran, "The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis" in Srpski arhiv za celokupno lekarstvo, 148, no. 5-6 (2020):280-285,
https://doi.org/10.2298/SARH190925022V . .

TY  - JOUR
AU  - Petrović, Milan
AU  - Jelovac, Drago
AU  - Antić, Svetlana
AU  - Antunović, Marija
AU  - Lukić, Nikola
AU  - Sabani, Melvil
AU  - Mudrak, Joerg
AU  - Jezdić, Zoran
AU  - Pucar, Ana
AU  - Stefanović, Aleksandar
AU  - Kuzmanović, Čedomir
AU  - Nikolić, Danilo
AU  - Konstantinović, Vitomir
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2443
AB  - This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies
VL  - 2019
DO  - 10.1155/2019/8345309
ER  - 

@article{
author = "Petrović, Milan and Jelovac, Drago and Antić, Svetlana and Antunović, Marija and Lukić, Nikola and Sabani, Melvil and Mudrak, Joerg and Jezdić, Zoran and Pucar, Ana and Stefanović, Aleksandar and Kuzmanović, Čedomir and Nikolić, Danilo and Konstantinović, Vitomir",
year = "2019",
abstract = "This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies",
volume = "2019",
doi = "10.1155/2019/8345309"
}

Petrović, M., Jelovac, D., Antić, S., Antunović, M., Lukić, N., Sabani, M., Mudrak, J., Jezdić, Z., Pucar, A., Stefanović, A., Kuzmanović, Č., Nikolić, D.,& Konstantinović, V.. (2019). Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International
Hindawi Ltd, London., 2019.
https://doi.org/10.1155/2019/8345309

Petrović M, Jelovac D, Antić S, Antunović M, Lukić N, Sabani M, Mudrak J, Jezdić Z, Pucar A, Stefanović A, Kuzmanović Č, Nikolić D, Konstantinović V. Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies. in Biomed Research International. 2019;2019.
doi:10.1155/2019/8345309 .

Petrović, Milan, Jelovac, Drago, Antić, Svetlana, Antunović, Marija, Lukić, Nikola, Sabani, Melvil, Mudrak, Joerg, Jezdić, Zoran, Pucar, Ana, Stefanović, Aleksandar, Kuzmanović, Čedomir, Nikolić, Danilo, Konstantinović, Vitomir, "Medication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studies" in Biomed Research International, 2019 (2019),
https://doi.org/10.1155/2019/8345309 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Mancić, Dragan
AU  - Jovanović, Igor
AU  - Šćepanović, Miodrag
AU  - Jezdić, Zoran
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1877
AB  - Objectives: To compare the effect of two surgical techniques, lateral condensation and bone drilling, on changes in temperature of the adjacent low-density bone during implant placement into posterior maxilla and to investigate the influence of the host factors - age, gender, region of implantation, bone density, and thickness of the cortical bone at the recipient sites. Material and methods: Local bone temperature was measured thermographically during implant placement into posterior maxilla following lateral bone condensing (test group) or bone drilling (controls). The main study outcomes were baseline bone temperature prior to implantation and maximum bone temperature recorded during implantation. Early implant success was evaluated after 6 months of healing. Results: A total of 40 implants were randomly allocated to test and control groups and placed into maxillary premolar and/or molar region of 18 participants of both genders and average age of 51.74 years. All recorded bone temperatures were below the threshold for thermal necrosis. Although both groups showed significant increase in bone temperature during implant placement procedure (P  lt = 0.0005), it was significantly higher for bone condensing compared with drilling (P  lt = 0.0005; 3.79 +/- 1.54 degrees C; 1.91 +/- 0.70 degrees C respectively). No host factor was singled out as a significant predictor of bone temperature changes, although trend of higher increase was observed in young patients, regardless of gender, during implant placement procedure into maxillary first premolar region with bone density type 3 and cortical layer thicker than 1 mm. Early implant success rate after 6 months follow-up was 100%. Conclusion: Although both surgical techniques, bone condensing and bone drilling, can be considered safe regarding their thermal effect on the bone of posterior maxilla, bone drilling is associated with fewer local bone heating during implantation. Host factors do not affect the bone thermal changes significantly.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique
VL  - 25
IS  - 8
SP  - 910
EP  - 918
DO  - 10.1111/clr.12191
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Mancić, Dragan and Jovanović, Igor and Šćepanović, Miodrag and Jezdić, Zoran",
year = "2014",
abstract = "Objectives: To compare the effect of two surgical techniques, lateral condensation and bone drilling, on changes in temperature of the adjacent low-density bone during implant placement into posterior maxilla and to investigate the influence of the host factors - age, gender, region of implantation, bone density, and thickness of the cortical bone at the recipient sites. Material and methods: Local bone temperature was measured thermographically during implant placement into posterior maxilla following lateral bone condensing (test group) or bone drilling (controls). The main study outcomes were baseline bone temperature prior to implantation and maximum bone temperature recorded during implantation. Early implant success was evaluated after 6 months of healing. Results: A total of 40 implants were randomly allocated to test and control groups and placed into maxillary premolar and/or molar region of 18 participants of both genders and average age of 51.74 years. All recorded bone temperatures were below the threshold for thermal necrosis. Although both groups showed significant increase in bone temperature during implant placement procedure (P  lt = 0.0005), it was significantly higher for bone condensing compared with drilling (P  lt = 0.0005; 3.79 +/- 1.54 degrees C; 1.91 +/- 0.70 degrees C respectively). No host factor was singled out as a significant predictor of bone temperature changes, although trend of higher increase was observed in young patients, regardless of gender, during implant placement procedure into maxillary first premolar region with bone density type 3 and cortical layer thicker than 1 mm. Early implant success rate after 6 months follow-up was 100%. Conclusion: Although both surgical techniques, bone condensing and bone drilling, can be considered safe regarding their thermal effect on the bone of posterior maxilla, bone drilling is associated with fewer local bone heating during implantation. Host factors do not affect the bone thermal changes significantly.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique",
volume = "25",
number = "8",
pages = "910-918",
doi = "10.1111/clr.12191"
}

Marković, A., Mišić, T., Mancić, D., Jovanović, I., Šćepanović, M.,& Jezdić, Z.. (2014). Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique. in Clinical Oral Implants Research
Wiley, Hoboken., 25(8), 910-918.
https://doi.org/10.1111/clr.12191

Marković A, Mišić T, Mancić D, Jovanović I, Šćepanović M, Jezdić Z. Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique. in Clinical Oral Implants Research. 2014;25(8):910-918.
doi:10.1111/clr.12191 .

Marković, Aleksa, Mišić, Tijana, Mancić, Dragan, Jovanović, Igor, Šćepanović, Miodrag, Jezdić, Zoran, "Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique" in Clinical Oral Implants Research, 25, no. 8 (2014):910-918,
https://doi.org/10.1111/clr.12191 . .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Tepavčević, Zvezdana
AU  - Jezdić, Zoran
AU  - Čarkić, Jelena
AU  - Toljić, Boško
AU  - Dedović-Tanić, Nasta
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1779
AB  - Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population.
AB  - Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands
T1  - Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda
VL  - 32
IS  - 4
SP  - 354
EP  - 360
DO  - 10.2478/jomb-2013-0048
ER  - 

@article{
author = "Nikolić, Nadja and Aničić, Boban and Tepavčević, Zvezdana and Jezdić, Zoran and Čarkić, Jelena and Toljić, Boško and Dedović-Tanić, Nasta and Konstantinović, Vitomir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2013",
abstract = "Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population., Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands, Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda",
volume = "32",
number = "4",
pages = "354-360",
doi = "10.2478/jomb-2013-0048"
}

Nikolić, N., Aničić, B., Tepavčević, Z., Jezdić, Z., Čarkić, J., Toljić, B., Dedović-Tanić, N., Konstantinović, V., Vukadinović, M.,& Milašin, J.. (2013). Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(4), 354-360.
https://doi.org/10.2478/jomb-2013-0048

Nikolić N, Aničić B, Tepavčević Z, Jezdić Z, Čarkić J, Toljić B, Dedović-Tanić N, Konstantinović V, Vukadinović M, Milašin J. Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry. 2013;32(4):354-360.
doi:10.2478/jomb-2013-0048 .

Nikolić, Nadja, Aničić, Boban, Tepavčević, Zvezdana, Jezdić, Zoran, Čarkić, Jelena, Toljić, Boško, Dedović-Tanić, Nasta, Konstantinović, Vitomir, Vukadinović, Miroslav, Milašin, Jelena, "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands" in Journal of Medical Biochemistry, 32, no. 4 (2013):354-360,
https://doi.org/10.2478/jomb-2013-0048 . .

TY  - THES
AU  - Jezdić, Zoran
PY  - 2010
UR  - https://plus.sr.cobiss.net/opac7/bib/1024103566
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/494
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Uticaj sagitalnih osteotomija donje vilice na temporomandibularni zglob
UR  - https://hdl.handle.net/21.15107/rcub_smile_494
ER  - 

@mastersthesis{
author = "Jezdić, Zoran",
year = "2010",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Uticaj sagitalnih osteotomija donje vilice na temporomandibularni zglob",
url = "https://hdl.handle.net/21.15107/rcub_smile_494"
}

Jezdić, Z.. (2010). Uticaj sagitalnih osteotomija donje vilice na temporomandibularni zglob. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_494

Jezdić Z. Uticaj sagitalnih osteotomija donje vilice na temporomandibularni zglob. 2010;.
https://hdl.handle.net/21.15107/rcub_smile_494 .

Jezdić, Zoran, "Uticaj sagitalnih osteotomija donje vilice na temporomandibularni zglob" (2010),
https://hdl.handle.net/21.15107/rcub_smile_494 .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Petrović, Milan
AU  - Medenica, Ljiljana M.
AU  - Lens, Marko
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1347
AB  - Background: The most common type of lip carcinoma is squamous cell carcinoma (SCC), accounting for approximately 90% of all oral malignancies. Currently, surgery and/or radiotherapy are considered the standards of care for SCC of the lip. Materials and Methods: We retrospectively analyzed medical records of patients diagnosed with SCC of the lip at the Clinic for Maxillofacial surgery at University of Belgrade (Belgrade, Serbia) during a period between 1991 and 2000. Results: A total of 223 patients with SCC of the lip were diagnosed and treated during a 10-year period. The overall male-to-female ratio was 5 to 0. The most frequently affected site was the lower lip (92.8%,). Mean diameter of the tumor was 30.1 mm (range, 5 to 80 full Neck lymph node metastases at presentation was detected in 26.5% of patients, who subsequently underwent neck dissection. We observed a linear trend in the association between the size of the tumor and the clinical stage of the neck (chi(2) = 15.1; df = 1; P  lt  .0001). Different surgical techniques were used for reconstruction of the lip defect after tumor removal. After a median follow-up of 56 months (range, 15 to 78 months), local recurrence occurred in 10.8% of patients while regional metastases developed in 4.5% of patients. Mortality from SCC of the lip was only 2.2%. Conclusion: SCC of the lip generally has a favorable outcome. Recently, there have been no major advances in lip reconstruction but rather continued improvement on accepted techniques. Early detection is essential for the successful treatment of SCC of the lip, which requires a multidisciplinary approach.
PB  - W B Saunders Co-Elsevier Inc, Philadelphia
T2  - Journal of Oral & Maxillofacial Surgery
T1  - Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients
VL  - 65
IS  - 4
SP  - 675
EP  - 679
DO  - 10.1016/j.joms.2006.03.054
ER  - 

@article{
author = "Vukadinović, Miroslav and Jezdić, Zoran and Petrović, Milan and Medenica, Ljiljana M. and Lens, Marko",
year = "2007",
abstract = "Background: The most common type of lip carcinoma is squamous cell carcinoma (SCC), accounting for approximately 90% of all oral malignancies. Currently, surgery and/or radiotherapy are considered the standards of care for SCC of the lip. Materials and Methods: We retrospectively analyzed medical records of patients diagnosed with SCC of the lip at the Clinic for Maxillofacial surgery at University of Belgrade (Belgrade, Serbia) during a period between 1991 and 2000. Results: A total of 223 patients with SCC of the lip were diagnosed and treated during a 10-year period. The overall male-to-female ratio was 5 to 0. The most frequently affected site was the lower lip (92.8%,). Mean diameter of the tumor was 30.1 mm (range, 5 to 80 full Neck lymph node metastases at presentation was detected in 26.5% of patients, who subsequently underwent neck dissection. We observed a linear trend in the association between the size of the tumor and the clinical stage of the neck (chi(2) = 15.1; df = 1; P  lt  .0001). Different surgical techniques were used for reconstruction of the lip defect after tumor removal. After a median follow-up of 56 months (range, 15 to 78 months), local recurrence occurred in 10.8% of patients while regional metastases developed in 4.5% of patients. Mortality from SCC of the lip was only 2.2%. Conclusion: SCC of the lip generally has a favorable outcome. Recently, there have been no major advances in lip reconstruction but rather continued improvement on accepted techniques. Early detection is essential for the successful treatment of SCC of the lip, which requires a multidisciplinary approach.",
publisher = "W B Saunders Co-Elsevier Inc, Philadelphia",
journal = "Journal of Oral & Maxillofacial Surgery",
title = "Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients",
volume = "65",
number = "4",
pages = "675-679",
doi = "10.1016/j.joms.2006.03.054"
}

Vukadinović, M., Jezdić, Z., Petrović, M., Medenica, L. M.,& Lens, M.. (2007). Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients. in Journal of Oral & Maxillofacial Surgery
W B Saunders Co-Elsevier Inc, Philadelphia., 65(4), 675-679.
https://doi.org/10.1016/j.joms.2006.03.054

Vukadinović M, Jezdić Z, Petrović M, Medenica LM, Lens M. Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients. in Journal of Oral & Maxillofacial Surgery. 2007;65(4):675-679.
doi:10.1016/j.joms.2006.03.054 .

Vukadinović, Miroslav, Jezdić, Zoran, Petrović, Milan, Medenica, Ljiljana M., Lens, Marko, "Surgical management of squamous cell carcinoma of the lip: Analysis of a 10-year experience in 223 patients" in Journal of Oral & Maxillofacial Surgery, 65, no. 4 (2007):675-679,
https://doi.org/10.1016/j.joms.2006.03.054 . .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Jezdić, Zoran
AU  - Aničić, Boban
AU  - Sinobad, Vladimir
AU  - Miković, Nikola
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1273
AB  - Background/Aim. To establish the influence of surgical corrections of mandibular prognathism upon the position of the lower and upper anterior teeth (incisors). Methods. The changes in position of the lower and upper anterior teeth (incisors) after the surgical correction of mandibular prognathism were analyzed by means of x-ray craniometry in 183 patients (female: n = 110, male: n = 73) in which the correction had been made in accordance with the principles of sagital osteotomy of the mandibular ramus. There were 4 angular and 2 linear parameters determined in the pre- and postoperative tele-xray-pictures. The changes of these parameters were tested by means of the parametric statistic tests. Results. The performed surgical procedures did not cause statistically significant changes in the angular parameters. The changes of both linear parameters were thought highly statistically significant. Conclusion. Under the influence of the performed surgical procedures no changes were found in the position of anterior teeth (incisors) in relation to SN and the mandibular plane. They were actually moved along with the medium fragment of the lower jaw and that fragment was moved linearly backwards along the occlusal plane with a practically insignificant rotation in the cranial direction.
AB  - Uvod/Cilj. Utvrditi uticaj hirurške korekcije mandibularnog prognatizma na položaj donjih i gornjih sekutića. Metode. Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma analizirane su rendgenkraniometrijski kod 183 osobe (ž = 110; m = 73) kod kojih je korekcija izvršena po principima sagitalnih osteotomija ramusa mandibule. Na preoperativnim i postoperativnim telerendgenogramima određivana su četiri angularna i dva linearna parametra. Promene tih parametara testirane su pomoću parametrijskih statističkih testova. Rezultati. Sprovedene hirurške procedure nisu izazvale statistički značajne promene angularnih parametara. Promene oba linearna parametra bile su visoko statistički značajne. Zaključak. Pod uticajem sprovedenih hirurških korektivnih procedura ne dolazi do promene položaja sekutića u odnosu na SN i mandibularnu ravan, već se oni pomeraju zajedno sa središnjim fragmentom donje vilice. Taj fragment se kreće translatorno unazad duž okluzalne ravni, sa praktično zanemarljivom rotacijom u kranijalnom pravcu.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism
T1  - Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma
VL  - 63
IS  - 5
SP  - 457
EP  - 460
DO  - 10.2298/VSP0605457V
ER  - 

@article{
author = "Vukadinović, Miroslav and Jezdić, Zoran and Aničić, Boban and Sinobad, Vladimir and Miković, Nikola",
year = "2006",
abstract = "Background/Aim. To establish the influence of surgical corrections of mandibular prognathism upon the position of the lower and upper anterior teeth (incisors). Methods. The changes in position of the lower and upper anterior teeth (incisors) after the surgical correction of mandibular prognathism were analyzed by means of x-ray craniometry in 183 patients (female: n = 110, male: n = 73) in which the correction had been made in accordance with the principles of sagital osteotomy of the mandibular ramus. There were 4 angular and 2 linear parameters determined in the pre- and postoperative tele-xray-pictures. The changes of these parameters were tested by means of the parametric statistic tests. Results. The performed surgical procedures did not cause statistically significant changes in the angular parameters. The changes of both linear parameters were thought highly statistically significant. Conclusion. Under the influence of the performed surgical procedures no changes were found in the position of anterior teeth (incisors) in relation to SN and the mandibular plane. They were actually moved along with the medium fragment of the lower jaw and that fragment was moved linearly backwards along the occlusal plane with a practically insignificant rotation in the cranial direction., Uvod/Cilj. Utvrditi uticaj hirurške korekcije mandibularnog prognatizma na položaj donjih i gornjih sekutića. Metode. Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma analizirane su rendgenkraniometrijski kod 183 osobe (ž = 110; m = 73) kod kojih je korekcija izvršena po principima sagitalnih osteotomija ramusa mandibule. Na preoperativnim i postoperativnim telerendgenogramima određivana su četiri angularna i dva linearna parametra. Promene tih parametara testirane su pomoću parametrijskih statističkih testova. Rezultati. Sprovedene hirurške procedure nisu izazvale statistički značajne promene angularnih parametara. Promene oba linearna parametra bile su visoko statistički značajne. Zaključak. Pod uticajem sprovedenih hirurških korektivnih procedura ne dolazi do promene položaja sekutića u odnosu na SN i mandibularnu ravan, već se oni pomeraju zajedno sa središnjim fragmentom donje vilice. Taj fragment se kreće translatorno unazad duž okluzalne ravni, sa praktično zanemarljivom rotacijom u kranijalnom pravcu.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism, Promene položaja donjih i gornjih sekutića posle hirurške korekcije mandibularnog prognatizma",
volume = "63",
number = "5",
pages = "457-460",
doi = "10.2298/VSP0605457V"
}

Vukadinović, M., Jezdić, Z., Aničić, B., Sinobad, V.,& Miković, N.. (2006). Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(5), 457-460.
https://doi.org/10.2298/VSP0605457V

Vukadinović M, Jezdić Z, Aničić B, Sinobad V, Miković N. Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism. in Vojnosanitetski pregled. 2006;63(5):457-460.
doi:10.2298/VSP0605457V .

Vukadinović, Miroslav, Jezdić, Zoran, Aničić, Boban, Sinobad, Vladimir, Miković, Nikola, "Positional changes of the lower and upper anterior teeth after surgical correction of mandibular prognathism" in Vojnosanitetski pregled, 63, no. 5 (2006):457-460,
https://doi.org/10.2298/VSP0605457V . .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Petrović, Milan
AU  - Jezdić, Zoran
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1270
AB  - Background/aim: Lip carcinoma makes about 1/4 of all oral carcinomas. Primary treatment of the lower lip carcinoma means radical excision of the full thickness of the lower lip tissue together with the tumor. The reconstruction of the defect accomplished after the removal of the lower lip tumor is a challenge for the surgeon and requires a detailed preoperative planning, the right choice of the method for reconstruction and the knowledge of the adequate surgical techniques needed. The aim of this study was to present a ten-year clinical results and experience concerning the reconstruction of lower lip defects longer than 4 cm by means of the modified Fries method in patients treated for the lower lip carcinoma. Methods. The reconstruction of the lower lip by means of the modified Fries method was performed in 37 patients. The following parameters were analyzed: sex, age, the time elapsed from the occurrence of the first symptoms until the first consultation with the doctor, the size of tumors, the size of the postexcision defect, TNM classification, the application of side diagnostic procedures, pathohistological diagnosis of postoperative complications. The sensibility of the lower lip region was monitored, as well as the obtained esthetic effects. Results. The results classified according to the mentioned parameters were processed, analyzed and displayed in detail. Clinical experience concerning the application of this reconstruction technique was presented and analyzed. Conclusion. The modified Fries technique can successfully be applied in the reconstruction of the lower lip defects longer than 4 cm because its application leads to satisfactory functional and acceptable esthetic results.
AB  - Uvod/cilj: Karcinomi usana čine približno oko 1/4 svih karcinoma usne duplje. Primarno lečenje karcinoma donje usne podrazumeva radikalnu eksciziju pune debljine tkiva donje usne zajedno sa tumorom. Nadoknada defekta nastalog nakon uklanjanja tumora donje usne predstavlja izazov za hirurga i zahteva detaljno preoperativno planiranje, pravilan izbor načina rekonstrukcije i poznavanje odgovarajućih hirurških tehnika. Cilj rada je da se kroz desetogodišnju retrospektivnu studiju prikažu naši klinički rezultati i iskustva u nadoknadi velikih defekata donje usne modifikovanom metodom po Friesu kod bolesnika lečenih od karcinoma donje usne. Metode. Od 256 bolesnika lečenih zbog tumora donje usne u periodu od 1992. do 2001. godine, kod 37 je primenjena rekonstrukcija modifikovanom metodom po Friesu. Analizirani su sledeći parametri: pol i godine starosti bolesnika, vreme proteklo od pojave prvih simptoma do javljanja lekaru, veličina tumora, veličina postekscizionog defekta, TNM klasifikacija, primena pomoćnih dijagnostičkih procedura, patohistološka dijagnoza, postoperativne komplikacije. Beležena su opažanja bolesnika u vezi senzibiliteta predela donje usne. Procenjivani su i ostvareni estetski efekti. Rezultati. Detaljno su obrađeni, analizirani i prikazani rezultati po navedenim parametrima. Izneta su naša klinička iskustva u primeni ove tehnike rekonstrukcije. Analizirane su njene prednosti i mane. Zaključak. Modifikovana tehnika po Friesu može se uspešno primeniti u rekonstrukciji defekata donje usne većih od 4 cm do potpunog nedostatka donje usne, jer se njenom primenom ostvaruju zadovoljavajući funkcionalni i prihvatljivi estetski rezultati.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor
T1  - Primena modifikovane metode po Friesu u rekonstrukciji donje usne posle uklanjanja malignih tumora
VL  - 63
IS  - 9
SP  - 801
EP  - 806
DO  - 10.2298/VSP0609801V
ER  - 

@article{
author = "Vukadinović, Miroslav and Petrović, Milan and Jezdić, Zoran",
year = "2006",
abstract = "Background/aim: Lip carcinoma makes about 1/4 of all oral carcinomas. Primary treatment of the lower lip carcinoma means radical excision of the full thickness of the lower lip tissue together with the tumor. The reconstruction of the defect accomplished after the removal of the lower lip tumor is a challenge for the surgeon and requires a detailed preoperative planning, the right choice of the method for reconstruction and the knowledge of the adequate surgical techniques needed. The aim of this study was to present a ten-year clinical results and experience concerning the reconstruction of lower lip defects longer than 4 cm by means of the modified Fries method in patients treated for the lower lip carcinoma. Methods. The reconstruction of the lower lip by means of the modified Fries method was performed in 37 patients. The following parameters were analyzed: sex, age, the time elapsed from the occurrence of the first symptoms until the first consultation with the doctor, the size of tumors, the size of the postexcision defect, TNM classification, the application of side diagnostic procedures, pathohistological diagnosis of postoperative complications. The sensibility of the lower lip region was monitored, as well as the obtained esthetic effects. Results. The results classified according to the mentioned parameters were processed, analyzed and displayed in detail. Clinical experience concerning the application of this reconstruction technique was presented and analyzed. Conclusion. The modified Fries technique can successfully be applied in the reconstruction of the lower lip defects longer than 4 cm because its application leads to satisfactory functional and acceptable esthetic results., Uvod/cilj: Karcinomi usana čine približno oko 1/4 svih karcinoma usne duplje. Primarno lečenje karcinoma donje usne podrazumeva radikalnu eksciziju pune debljine tkiva donje usne zajedno sa tumorom. Nadoknada defekta nastalog nakon uklanjanja tumora donje usne predstavlja izazov za hirurga i zahteva detaljno preoperativno planiranje, pravilan izbor načina rekonstrukcije i poznavanje odgovarajućih hirurških tehnika. Cilj rada je da se kroz desetogodišnju retrospektivnu studiju prikažu naši klinički rezultati i iskustva u nadoknadi velikih defekata donje usne modifikovanom metodom po Friesu kod bolesnika lečenih od karcinoma donje usne. Metode. Od 256 bolesnika lečenih zbog tumora donje usne u periodu od 1992. do 2001. godine, kod 37 je primenjena rekonstrukcija modifikovanom metodom po Friesu. Analizirani su sledeći parametri: pol i godine starosti bolesnika, vreme proteklo od pojave prvih simptoma do javljanja lekaru, veličina tumora, veličina postekscizionog defekta, TNM klasifikacija, primena pomoćnih dijagnostičkih procedura, patohistološka dijagnoza, postoperativne komplikacije. Beležena su opažanja bolesnika u vezi senzibiliteta predela donje usne. Procenjivani su i ostvareni estetski efekti. Rezultati. Detaljno su obrađeni, analizirani i prikazani rezultati po navedenim parametrima. Izneta su naša klinička iskustva u primeni ove tehnike rekonstrukcije. Analizirane su njene prednosti i mane. Zaključak. Modifikovana tehnika po Friesu može se uspešno primeniti u rekonstrukciji defekata donje usne većih od 4 cm do potpunog nedostatka donje usne, jer se njenom primenom ostvaruju zadovoljavajući funkcionalni i prihvatljivi estetski rezultati.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor, Primena modifikovane metode po Friesu u rekonstrukciji donje usne posle uklanjanja malignih tumora",
volume = "63",
number = "9",
pages = "801-806",
doi = "10.2298/VSP0609801V"
}

Vukadinović, M., Petrović, M.,& Jezdić, Z.. (2006). Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 63(9), 801-806.
https://doi.org/10.2298/VSP0609801V

Vukadinović M, Petrović M, Jezdić Z. Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor. in Vojnosanitetski pregled. 2006;63(9):801-806.
doi:10.2298/VSP0609801V .

Vukadinović, Miroslav, Petrović, Milan, Jezdić, Zoran, "Use of the modified Fries technique in the reconstruction of the lower lip after the removal of a malignant tumor" in Vojnosanitetski pregled, 63, no. 9 (2006):801-806,
https://doi.org/10.2298/VSP0609801V . .

TY  - JOUR
AU  - Vukadinović, Miroslav
AU  - Aničić, Boban
AU  - Jezdić, Zoran
AU  - Miković, Nikola
AU  - Sinobad, Vladimir
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1259
AB  - The aim of this study was to establish and estimate the effects of surgical correction of mandibular prognathism on the height and position of the upper lip. The changes of the upper lip were analyzed on 115 patients between 16 and 30 year of age (71 females and 44 males) who were subject to surgical correction of mandibular prognathism using the sagittal split ramus osteotomy. The lateral cephalometric radiographs were taken of each patient before and six months after the surgical procedure. The soft tissue cephalometric analysis included the measurements of six linear and two angular parameters. The obtained data were statistically processed and evaluated. Statistical analysis revealed the significant changes in two linear cephalometric parameters after surgical procedure - the incisal step and the length of the upper lip. The changes in the length and position of the upper lip after surgical correction of mandibular prognathism by means of sagittal split ramus osteotomy seem to be minor and clinically insignificant. Only the length of the upper lip was significantly changed. It became longer. The upper lip advancement amounted approximately 15% of the complete mandibular set-back during operation.
AB  - Cilj istraživanja je bio da utvrdi i proceni efekte hirurške korekcije mandibularnog prognatizma na dužinu i položaj gornje usne. Promene gornje usne su kefalometrijski analizirane kod 115 osoba (f=71; m=44) kod kojih je mandibularni prognatizam korigovan metodom sagitalnih osteotomija grane donje vilice. Svakom pacijentu su načinjena po dva profilna telerendgenska snimka glave, jedan pre i jedan nakon hirurške intervencije. Kefalometrijska analiza mekog profila lica je obavljena merenjem i poređenjem šest linearnih i dva angularna parametra. Dobijene vrednosti su statistički obrađene i evoluirane. Primenjene hirurške korektivne procedure rezultirale su statistički značajnim promenama kod dva linearna parametra (incizalna stepenica i dužina gornje usne). Promene gornje usne posle hirurške korekcije mandibularnog prognatizma pomoću sagitalnih klizajućih osteotomija grane donje vilice su minimalne i gotovo neznačajne. Značajno se menja jedino dužina gornje usne - postaje duža. Gornja usna se pomera za 15% ukupnog pomeranja struktura donje vilice.
PB  - Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš
T2  - Acta stomatologica Naissi
T1  - Changes of the upper lip after surgical correction of mandibular prognathism
T1  - Promene gornje usne posle hirurške korekcije progenije
VL  - 21
IS  - 52
SP  - 527
EP  - 534
UR  - https://hdl.handle.net/21.15107/rcub_smile_1259
ER  - 

@article{
author = "Vukadinović, Miroslav and Aničić, Boban and Jezdić, Zoran and Miković, Nikola and Sinobad, Vladimir",
year = "2005",
abstract = "The aim of this study was to establish and estimate the effects of surgical correction of mandibular prognathism on the height and position of the upper lip. The changes of the upper lip were analyzed on 115 patients between 16 and 30 year of age (71 females and 44 males) who were subject to surgical correction of mandibular prognathism using the sagittal split ramus osteotomy. The lateral cephalometric radiographs were taken of each patient before and six months after the surgical procedure. The soft tissue cephalometric analysis included the measurements of six linear and two angular parameters. The obtained data were statistically processed and evaluated. Statistical analysis revealed the significant changes in two linear cephalometric parameters after surgical procedure - the incisal step and the length of the upper lip. The changes in the length and position of the upper lip after surgical correction of mandibular prognathism by means of sagittal split ramus osteotomy seem to be minor and clinically insignificant. Only the length of the upper lip was significantly changed. It became longer. The upper lip advancement amounted approximately 15% of the complete mandibular set-back during operation., Cilj istraživanja je bio da utvrdi i proceni efekte hirurške korekcije mandibularnog prognatizma na dužinu i položaj gornje usne. Promene gornje usne su kefalometrijski analizirane kod 115 osoba (f=71; m=44) kod kojih je mandibularni prognatizam korigovan metodom sagitalnih osteotomija grane donje vilice. Svakom pacijentu su načinjena po dva profilna telerendgenska snimka glave, jedan pre i jedan nakon hirurške intervencije. Kefalometrijska analiza mekog profila lica je obavljena merenjem i poređenjem šest linearnih i dva angularna parametra. Dobijene vrednosti su statistički obrađene i evoluirane. Primenjene hirurške korektivne procedure rezultirale su statistički značajnim promenama kod dva linearna parametra (incizalna stepenica i dužina gornje usne). Promene gornje usne posle hirurške korekcije mandibularnog prognatizma pomoću sagitalnih klizajućih osteotomija grane donje vilice su minimalne i gotovo neznačajne. Značajno se menja jedino dužina gornje usne - postaje duža. Gornja usna se pomera za 15% ukupnog pomeranja struktura donje vilice.",
publisher = "Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš",
journal = "Acta stomatologica Naissi",
title = "Changes of the upper lip after surgical correction of mandibular prognathism, Promene gornje usne posle hirurške korekcije progenije",
volume = "21",
number = "52",
pages = "527-534",
url = "https://hdl.handle.net/21.15107/rcub_smile_1259"
}

Vukadinović, M., Aničić, B., Jezdić, Z., Miković, N.,& Sinobad, V.. (2005). Changes of the upper lip after surgical correction of mandibular prognathism. in Acta stomatologica Naissi
Univerzitet u Nišu - Medicinski fakultet, Niš i Klinika za stomatologiju, Niš., 21(52), 527-534.
https://hdl.handle.net/21.15107/rcub_smile_1259

Vukadinović M, Aničić B, Jezdić Z, Miković N, Sinobad V. Changes of the upper lip after surgical correction of mandibular prognathism. in Acta stomatologica Naissi. 2005;21(52):527-534.
https://hdl.handle.net/21.15107/rcub_smile_1259 .

Vukadinović, Miroslav, Aničić, Boban, Jezdić, Zoran, Miković, Nikola, Sinobad, Vladimir, "Changes of the upper lip after surgical correction of mandibular prognathism" in Acta stomatologica Naissi, 21, no. 52 (2005):527-534,
https://hdl.handle.net/21.15107/rcub_smile_1259 .