TY  - JOUR
AU  - Vučetić, Milan
AU  - Roganović, Jelena
AU  - Freilich, M.
AU  - Shafer, D.
AU  - Milić, Marija
AU  - Đukić, Ljiljana
AU  - Petrović, Nina
AU  - Marković, Evgenija
AU  - Marković, Aleksa
AU  - Brković, Božidar
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2481
AB  - Objective: To evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. Material and methods: Twenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL-1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded. Results: MiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance. Conclusion: Delayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. Clinical relevance: Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset.
PB  - Springer
T2  - Clinical Oral Investigations
T1  - Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort
DO  - 10.1007/s00784-020-03366-6
ER  - 

@article{
author = "Vučetić, Milan and Roganović, Jelena and Freilich, M. and Shafer, D. and Milić, Marija and Đukić, Ljiljana and Petrović, Nina and Marković, Evgenija and Marković, Aleksa and Brković, Božidar",
year = "2020",
abstract = "Objective: To evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. Material and methods: Twenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL-1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded. Results: MiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance. Conclusion: Delayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. Clinical relevance: Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset.",
publisher = "Springer",
journal = "Clinical Oral Investigations",
title = "Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort",
doi = "10.1007/s00784-020-03366-6"
}

Vučetić, M., Roganović, J., Freilich, M., Shafer, D., Milić, M., Đukić, L., Petrović, N., Marković, E., Marković, A.,& Brković, B.. (2020). Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort. in Clinical Oral Investigations
Springer..
https://doi.org/10.1007/s00784-020-03366-6

Vučetić M, Roganović J, Freilich M, Shafer D, Milić M, Đukić L, Petrović N, Marković E, Marković A, Brković B. Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort. in Clinical Oral Investigations. 2020;.
doi:10.1007/s00784-020-03366-6 .

Vučetić, Milan, Roganović, Jelena, Freilich, M., Shafer, D., Milić, Marija, Đukić, Ljiljana, Petrović, Nina, Marković, Evgenija, Marković, Aleksa, Brković, Božidar, "Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort" in Clinical Oral Investigations (2020),
https://doi.org/10.1007/s00784-020-03366-6 . .

TY  - JOUR
AU  - Taso, Ervin
AU  - Stefanović, Vladimir
AU  - Stevanović, Ivana
AU  - Vojvodić, Danilo
AU  - Topić, Aleksandra
AU  - Petković-Ćurčin, Aleksandra
AU  - Obradović-Đuričić, Kosovka
AU  - Marković, Aleksa
AU  - Đukić, Mirjana
AU  - Vujanović, Dragana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2324
AB  - Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine & Cellular Longevity
T1  - Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid
VL  - 2018
DO  - 10.1155/2018/1823189
ER  - 

@article{
author = "Taso, Ervin and Stefanović, Vladimir and Stevanović, Ivana and Vojvodić, Danilo and Topić, Aleksandra and Petković-Ćurčin, Aleksandra and Obradović-Đuričić, Kosovka and Marković, Aleksa and Đukić, Mirjana and Vujanović, Dragana",
year = "2018",
abstract = "Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine & Cellular Longevity",
title = "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid",
volume = "2018",
doi = "10.1155/2018/1823189"
}

Taso, E., Stefanović, V., Stevanović, I., Vojvodić, D., Topić, A., Petković-Ćurčin, A., Obradović-Đuričić, K., Marković, A., Đukić, M.,& Vujanović, D.. (2018). Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine & Cellular Longevity
Hindawi Ltd, London., 2018.
https://doi.org/10.1155/2018/1823189

Taso E, Stefanović V, Stevanović I, Vojvodić D, Topić A, Petković-Ćurčin A, Obradović-Đuričić K, Marković A, Đukić M, Vujanović D. Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine & Cellular Longevity. 2018;2018.
doi:10.1155/2018/1823189 .

Taso, Ervin, Stefanović, Vladimir, Stevanović, Ivana, Vojvodić, Danilo, Topić, Aleksandra, Petković-Ćurčin, Aleksandra, Obradović-Đuričić, Kosovka, Marković, Aleksa, Đukić, Mirjana, Vujanović, Dragana, "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid" in Oxidative Medicine & Cellular Longevity, 2018 (2018),
https://doi.org/10.1155/2018/1823189 . .

TY  - JOUR
AU  - Vlahović, Zoran
AU  - Marković, Aleksa
AU  - Lazić, Zoran
AU  - Šćepanović, Miodrag
AU  - Đinić, Ana
AU  - Kalanović, Milena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2219
AB  - AimTo evaluate by histopathological analysis the peri-implant bone inflammation degree, in certain time intervals (7, 14, 21 and 28days), following mini-incision flapless and flap implant placement. Material and methodsThe experiment was conducted on four domestic pigs. Nine weeks prior to implant insertion, second and third mandibular premolars were extracted. Each animal received six implants in lower jaw. On one randomly chosen side of jaw flapless technique using mini-incision was performed, while on the other side implants were inserted after flap raising. After 7, 14, 21, and 28days, the experimental animals were sacrificed. Following mandibular resection and decalcification, the samples for histopathological analysis of the peri-implant bone were obtained in the empty implant bed area, from the buccal side of the mandible, adjacent to implant neck region and parallel to crestal edge of implant bed. The degree of inflammatory response of the peri-implant bone was estimated through ordinal scores from 0 to 2. ResultsSeven days after the surgery all samples in the flap group had score 2 indicating high inflammation degree, in contrast to lower inflammatory reaction in flapless group. On the 14th and 21st postoperative day decreasing of inflammation degree was noted in all samples of the flapless group (score 1), while in flap group samples presented scores 1 and 2. Twenty-eight days after the implant placement, further reduction of inflammation in the flapless group (33% of samples had score 0) was observed. ConclusionFlapless technique in comparison to conventional flap procedure minimizes postoperative bone inflammatory reactions.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs
VL  - 28
IS  - 9
SP  - 1067
EP  - 1073
DO  - 10.1111/clr.12919
ER  - 

@article{
author = "Vlahović, Zoran and Marković, Aleksa and Lazić, Zoran and Šćepanović, Miodrag and Đinić, Ana and Kalanović, Milena",
year = "2017",
abstract = "AimTo evaluate by histopathological analysis the peri-implant bone inflammation degree, in certain time intervals (7, 14, 21 and 28days), following mini-incision flapless and flap implant placement. Material and methodsThe experiment was conducted on four domestic pigs. Nine weeks prior to implant insertion, second and third mandibular premolars were extracted. Each animal received six implants in lower jaw. On one randomly chosen side of jaw flapless technique using mini-incision was performed, while on the other side implants were inserted after flap raising. After 7, 14, 21, and 28days, the experimental animals were sacrificed. Following mandibular resection and decalcification, the samples for histopathological analysis of the peri-implant bone were obtained in the empty implant bed area, from the buccal side of the mandible, adjacent to implant neck region and parallel to crestal edge of implant bed. The degree of inflammatory response of the peri-implant bone was estimated through ordinal scores from 0 to 2. ResultsSeven days after the surgery all samples in the flap group had score 2 indicating high inflammation degree, in contrast to lower inflammatory reaction in flapless group. On the 14th and 21st postoperative day decreasing of inflammation degree was noted in all samples of the flapless group (score 1), while in flap group samples presented scores 1 and 2. Twenty-eight days after the implant placement, further reduction of inflammation in the flapless group (33% of samples had score 0) was observed. ConclusionFlapless technique in comparison to conventional flap procedure minimizes postoperative bone inflammatory reactions.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs",
volume = "28",
number = "9",
pages = "1067-1073",
doi = "10.1111/clr.12919"
}

Vlahović, Z., Marković, A., Lazić, Z., Šćepanović, M., Đinić, A.,& Kalanović, M.. (2017). Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs. in Clinical Oral Implants Research
Wiley, Hoboken., 28(9), 1067-1073.
https://doi.org/10.1111/clr.12919

Vlahović Z, Marković A, Lazić Z, Šćepanović M, Đinić A, Kalanović M. Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs. in Clinical Oral Implants Research. 2017;28(9):1067-1073.
doi:10.1111/clr.12919 .

Vlahović, Zoran, Marković, Aleksa, Lazić, Zoran, Šćepanović, Miodrag, Đinić, Ana, Kalanović, Milena, "Histopathological comparative analysis of periimplant bone inflammatory response after dental implant insertion using flap and flapless surgical technique. An experimental study in pigs" in Clinical Oral Implants Research, 28, no. 9 (2017):1067-1073,
https://doi.org/10.1111/clr.12919 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Đinić, Ana
AU  - Calvo Guirado, Jose Luis
AU  - Tahmaseb, Ali
AU  - Šćepanović, Miodrag
AU  - Janjić, Bojan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2214
AB  - ObjectivesTo compare the peri-implant bone healing between TiZr implants with hydrophilic SLActive and hydrophobic SLA implant surface in patients receiving anticoagulants, to assess the implant survival and success rate, as well as to evaluate whether small-diameter TiZr implants could be used in patients on OAT in order to avoid augmentation procedures. Material and methodsA total of 80 small-diameter tissue-level TiZr implants with SLActive and SLA surfaces were placed in 20 anticoagulated patients, following the split-mouth study design. Implant stability was measured up to the third postoperative month by resonance frequency measurements (RFA). One-year implant survival and success rate were evaluated. ResultsAfter one year, 100% implant survival and success rate were observed. A significant decrease in ISQ comparing to baseline values was noted in the SLActive group from the first postoperative week, and in the SLA group, from the 3rdweek after the surgery. In both groups, a statistically significant decline in ISQ was observed between second and third postoperative week. No significant differences in ISQ values between SLActive and SLA implants were noted, at any time point. ConclusionsTitanium-zirconium small-diameter implants with SLActive and SLA surface predictably achieve and maintain adequate bone tissue integration in patients receiving anticoagulants. OAT appears to influence the bone healing events resulting in lower ISQ in the end of 3-month period in comparison with baseline values, although without compromising implant stability.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants
VL  - 28
IS  - 10
SP  - 1241
EP  - 1247
DO  - 10.1111/clr.12948
ER  - 

@article{
author = "Marković, Aleksa and Đinić, Ana and Calvo Guirado, Jose Luis and Tahmaseb, Ali and Šćepanović, Miodrag and Janjić, Bojan",
year = "2017",
abstract = "ObjectivesTo compare the peri-implant bone healing between TiZr implants with hydrophilic SLActive and hydrophobic SLA implant surface in patients receiving anticoagulants, to assess the implant survival and success rate, as well as to evaluate whether small-diameter TiZr implants could be used in patients on OAT in order to avoid augmentation procedures. Material and methodsA total of 80 small-diameter tissue-level TiZr implants with SLActive and SLA surfaces were placed in 20 anticoagulated patients, following the split-mouth study design. Implant stability was measured up to the third postoperative month by resonance frequency measurements (RFA). One-year implant survival and success rate were evaluated. ResultsAfter one year, 100% implant survival and success rate were observed. A significant decrease in ISQ comparing to baseline values was noted in the SLActive group from the first postoperative week, and in the SLA group, from the 3rdweek after the surgery. In both groups, a statistically significant decline in ISQ was observed between second and third postoperative week. No significant differences in ISQ values between SLActive and SLA implants were noted, at any time point. ConclusionsTitanium-zirconium small-diameter implants with SLActive and SLA surface predictably achieve and maintain adequate bone tissue integration in patients receiving anticoagulants. OAT appears to influence the bone healing events resulting in lower ISQ in the end of 3-month period in comparison with baseline values, although without compromising implant stability.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants",
volume = "28",
number = "10",
pages = "1241-1247",
doi = "10.1111/clr.12948"
}

Marković, A., Đinić, A., Calvo Guirado, J. L., Tahmaseb, A., Šćepanović, M.,& Janjić, B.. (2017). Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants. in Clinical Oral Implants Research
Wiley, Hoboken., 28(10), 1241-1247.
https://doi.org/10.1111/clr.12948

Marković A, Đinić A, Calvo Guirado JL, Tahmaseb A, Šćepanović M, Janjić B. Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants. in Clinical Oral Implants Research. 2017;28(10):1241-1247.
doi:10.1111/clr.12948 .

Marković, Aleksa, Đinić, Ana, Calvo Guirado, Jose Luis, Tahmaseb, Ali, Šćepanović, Miodrag, Janjić, Bojan, "Randomized clinical study of the peri-implant healing to hydrophilic and hydrophobic implant surfaces in patients receiving anticoagulants" in Clinical Oral Implants Research, 28, no. 10 (2017):1241-1247,
https://doi.org/10.1111/clr.12948 . .

TY  - JOUR
AU  - Gehrke, Sergio A.
AU  - Perez-Albacete, Carlos
AU  - Martinez
AU  - Piattelli, Adriano
AU  - Shibli, Jamil A.
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2193
AB  - Objectives: The aim of this study was to perform a histomorphometric and biomechanical comparison of three implants with different designs of the apical area to promote a better bone initial stability and its correlation with the osseointegration. Material and methods: Fifty-four tapered implants with same length, diameter and surface properties but with three different apical configurations (Group I: MK4: Group II: C1 and Group III: MK7) were inserted in the tibia of rabbits. Implant stability and bone formation were evaluated by resonance frequency analysis measured at 0, 6, 8 and 12 weeks and by histomorphometric analysis performed at 6, 8 and 12 weeks. Results: Statistical test to compare the stability through the implant stability quotient in the four times showed few differences between the groups and time periods proposed, with significance set at P  lt  0.05. In the bone-implant contact, by comparing the groups in the three times proposed, it was possible concluded that there is a similar behavior among the three implant design (P  lt  0.05). Conclusion: With the limitations of this animal study, it can be concluded that the design of the apical area influences the implant stability and the bone-to-implant contact.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits
VL  - 28
IS  - 3
SP  - 355
EP  - 361
DO  - 10.1111/clr.12807
ER  - 

@article{
author = "Gehrke, Sergio A. and Perez-Albacete, Carlos and Martinez and Piattelli, Adriano and Shibli, Jamil A. and Marković, Aleksa and Calvo Guirado, Jose Luis",
year = "2017",
abstract = "Objectives: The aim of this study was to perform a histomorphometric and biomechanical comparison of three implants with different designs of the apical area to promote a better bone initial stability and its correlation with the osseointegration. Material and methods: Fifty-four tapered implants with same length, diameter and surface properties but with three different apical configurations (Group I: MK4: Group II: C1 and Group III: MK7) were inserted in the tibia of rabbits. Implant stability and bone formation were evaluated by resonance frequency analysis measured at 0, 6, 8 and 12 weeks and by histomorphometric analysis performed at 6, 8 and 12 weeks. Results: Statistical test to compare the stability through the implant stability quotient in the four times showed few differences between the groups and time periods proposed, with significance set at P  lt  0.05. In the bone-implant contact, by comparing the groups in the three times proposed, it was possible concluded that there is a similar behavior among the three implant design (P  lt  0.05). Conclusion: With the limitations of this animal study, it can be concluded that the design of the apical area influences the implant stability and the bone-to-implant contact.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits",
volume = "28",
number = "3",
pages = "355-361",
doi = "10.1111/clr.12807"
}

Gehrke, S. A., Perez-Albacete, C., Martinez, Piattelli, A., Shibli, J. A., Marković, A.,& Calvo Guirado, J. L.. (2017). The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits. in Clinical Oral Implants Research
Wiley, Hoboken., 28(3), 355-361.
https://doi.org/10.1111/clr.12807

Gehrke SA, Perez-Albacete C, Martinez, Piattelli A, Shibli JA, Marković A, Calvo Guirado JL. The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits. in Clinical Oral Implants Research. 2017;28(3):355-361.
doi:10.1111/clr.12807 .

Gehrke, Sergio A., Perez-Albacete, Carlos, Martinez, Piattelli, Adriano, Shibli, Jamil A., Marković, Aleksa, Calvo Guirado, Jose Luis, "The influence of three different apical implant designs at stability and osseointegration process: experimental study in rabbits" in Clinical Oral Implants Research, 28, no. 3 (2017):355-361,
https://doi.org/10.1111/clr.12807 . .

TY  - JOUR
AU  - Glišić, Mirko
AU  - Stamenković, Dragoslav
AU  - Grbović, Aleksandar
AU  - Todorović, Aleksandar
AU  - Marković, Aleksa
AU  - Trifković, Branka
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2159
AB  - Introduction Differences between the tooth and implant response to load can lead to many biological and technical implications in the conditions of occlusal forces. Objective The objective of this study was to analyze load distribution in tooth/implant-supported fixed partial dentures with the use of resilient TSA (Titan Shock Absorber, BoneCare GmbH, Augsburg, Germany) abutment and conventional non-resilient abutment using finite element method. Methods This study presents two basic 3D models. For one model a standard non-resilient abutment is used, and on the implant of the second model a resilient TSA abutment is applied. The virtual model contains drawn contours of tooth, mucous membranes, implant, cortical bones and spongiosa, abutment and suprastructure. The experiment used 500 N of vertical force, applied in three different cases of axial load. Calculations of von Mises equivalent stresses of the tooth root and periodontium, implants and peri-implant tissue were made. Results For the model to which a non-resilient abutment is applied, maximum stress values in all three cases are observed in the cortical part of the bone (maximum stress value of 49.7 MPa). Measurements of stress and deformation in the bone tissue in the model with application of the resilient TSA abutment demonstrated similar distribution; however, these values are many times lower than in the model with non-resilient TSA abutment (maximum stress value of 28.9 MPa). Conclusion Application of the resilient TSA abutment results in more equal distribution of stress and deformations in the bone tissue under vertical forces. These values are many times lower than in the model with the non-resilient abutment.
AB  - Uvod Razlike u odgovoru zuba i implantata na opterećenje mogu imati za posledicu niz bioloških i tehničkih komplikacija u uslovima delovanja okluzalnih sila. Cilj rada Cilj ovog rada je da se analizira distribucija opterećenja kod mešovito nošenih mostova sa primenom rezilijentnog TSA abatmenta (Titan Shock Absorber, BoneCare GmbH Germany), kao i konvencionalnog nerezilijentnog abatmenta primenom metode konačnih elemenata (MKE). Metode rada U ovom radu napravljena su dva osnovna 3D modela. Na jednom implantatu i modelu korišćen je standardni nerezilijentni abatment, a na implantatu drugog modela korišćen je rezilijentni TSA abatment. Na virtuelnom modelu su modelirane konture zuba, PDL-a, sluzokože, implantata, kortikalne i spongiozne kosti, abatmenta i suprastrukture. U eksperimentu je korišćena vertikalna sila od 500 N, koja je primenjena u tri različita slučaja aksijalnog opterećenja. Metodom konačnih elemenata izračunavani su potom Fon Mizesovi ekvivalentni naponi u korenu zuba i parodoncijumu, implantatu i periimplantatnom tkivu. Rezultati Na modelu kod koga je primenjen nerezilijentni abatment, maksimalne vrednosti napona i deformacije u sva tri slučaja su registrovane u kortikalnom delu kosti oko zuba i implantata u zavisnosti od napadne tačke sile (maksimalan napon 49,7 MPa). Vrednosti napona i deformacija na modelu sa primenom rezilijentnog TSA abatmenta pokazale su sličnu raspodelu u kosti, međutim ove vrednosti su višestruko manje nego kod modela sa nerezilijentnim abatmentom (maksimalan napon 28,9 MPa). Zaključak Primena rezilijentnog TSA abatmenta dovodi do ravnomernije raspodele napona i deformacije u koštanom tkivu oko zuba i implantata pod dejstvom vertikalnih sila. Izmerene vrednosti su višestruko manje nego na modelu sa nerezilijentnim abatmentom.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment
T1  - Analiza distribucije opterećenja kod mešovito nošenih mostova primenom rezilijentnih abatmenata
VL  - 144
IS  - 3-4
SP  - 188
EP  - 195
DO  - 10.2298/sarh1604188G
ER  - 

@article{
author = "Glišić, Mirko and Stamenković, Dragoslav and Grbović, Aleksandar and Todorović, Aleksandar and Marković, Aleksa and Trifković, Branka",
year = "2016",
abstract = "Introduction Differences between the tooth and implant response to load can lead to many biological and technical implications in the conditions of occlusal forces. Objective The objective of this study was to analyze load distribution in tooth/implant-supported fixed partial dentures with the use of resilient TSA (Titan Shock Absorber, BoneCare GmbH, Augsburg, Germany) abutment and conventional non-resilient abutment using finite element method. Methods This study presents two basic 3D models. For one model a standard non-resilient abutment is used, and on the implant of the second model a resilient TSA abutment is applied. The virtual model contains drawn contours of tooth, mucous membranes, implant, cortical bones and spongiosa, abutment and suprastructure. The experiment used 500 N of vertical force, applied in three different cases of axial load. Calculations of von Mises equivalent stresses of the tooth root and periodontium, implants and peri-implant tissue were made. Results For the model to which a non-resilient abutment is applied, maximum stress values in all three cases are observed in the cortical part of the bone (maximum stress value of 49.7 MPa). Measurements of stress and deformation in the bone tissue in the model with application of the resilient TSA abutment demonstrated similar distribution; however, these values are many times lower than in the model with non-resilient TSA abutment (maximum stress value of 28.9 MPa). Conclusion Application of the resilient TSA abutment results in more equal distribution of stress and deformations in the bone tissue under vertical forces. These values are many times lower than in the model with the non-resilient abutment., Uvod Razlike u odgovoru zuba i implantata na opterećenje mogu imati za posledicu niz bioloških i tehničkih komplikacija u uslovima delovanja okluzalnih sila. Cilj rada Cilj ovog rada je da se analizira distribucija opterećenja kod mešovito nošenih mostova sa primenom rezilijentnog TSA abatmenta (Titan Shock Absorber, BoneCare GmbH Germany), kao i konvencionalnog nerezilijentnog abatmenta primenom metode konačnih elemenata (MKE). Metode rada U ovom radu napravljena su dva osnovna 3D modela. Na jednom implantatu i modelu korišćen je standardni nerezilijentni abatment, a na implantatu drugog modela korišćen je rezilijentni TSA abatment. Na virtuelnom modelu su modelirane konture zuba, PDL-a, sluzokože, implantata, kortikalne i spongiozne kosti, abatmenta i suprastrukture. U eksperimentu je korišćena vertikalna sila od 500 N, koja je primenjena u tri različita slučaja aksijalnog opterećenja. Metodom konačnih elemenata izračunavani su potom Fon Mizesovi ekvivalentni naponi u korenu zuba i parodoncijumu, implantatu i periimplantatnom tkivu. Rezultati Na modelu kod koga je primenjen nerezilijentni abatment, maksimalne vrednosti napona i deformacije u sva tri slučaja su registrovane u kortikalnom delu kosti oko zuba i implantata u zavisnosti od napadne tačke sile (maksimalan napon 49,7 MPa). Vrednosti napona i deformacija na modelu sa primenom rezilijentnog TSA abatmenta pokazale su sličnu raspodelu u kosti, međutim ove vrednosti su višestruko manje nego kod modela sa nerezilijentnim abatmentom (maksimalan napon 28,9 MPa). Zaključak Primena rezilijentnog TSA abatmenta dovodi do ravnomernije raspodele napona i deformacije u koštanom tkivu oko zuba i implantata pod dejstvom vertikalnih sila. Izmerene vrednosti su višestruko manje nego na modelu sa nerezilijentnim abatmentom.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment, Analiza distribucije opterećenja kod mešovito nošenih mostova primenom rezilijentnih abatmenata",
volume = "144",
number = "3-4",
pages = "188-195",
doi = "10.2298/sarh1604188G"
}

Glišić, M., Stamenković, D., Grbović, A., Todorović, A., Marković, A.,& Trifković, B.. (2016). Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 144(3-4), 188-195.
https://doi.org/10.2298/sarh1604188G

Glišić M, Stamenković D, Grbović A, Todorović A, Marković A, Trifković B. Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment. in Srpski arhiv za celokupno lekarstvo. 2016;144(3-4):188-195.
doi:10.2298/sarh1604188G .

Glišić, Mirko, Stamenković, Dragoslav, Grbović, Aleksandar, Todorović, Aleksandar, Marković, Aleksa, Trifković, Branka, "Analysis of load distribution in tooth-implant supported fixed partial dentures by the use of resilient abutment" in Srpski arhiv za celokupno lekarstvo, 144, no. 3-4 (2016):188-195,
https://doi.org/10.2298/sarh1604188G . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Calvo Guirado, Jose Luis
AU  - Delgado-Ruiz, Rafael
AU  - Janjić, Bojan
AU  - Abboud, Marcus
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2126
AB  - Purpose: To evaluate stability and success rate of hydrophilic nanostructured implants placed via osteotome sinus floor elevation (OSFE) without grafting material or using beta-tricalcium phosphate (beta-TCP), deproteinized bovine bone (DBB), or their combination, and also to assess three-dimensional volumetric stability of endo-sinus bone gained in the aforementioned conditions. Materials and Methods: OSFE with simultaneous implant placement (10-mm long SLActive-BL (R), Straumann, Basel, Switzerland) was performed. Grafting materials were randomly allocated to implant sites, whereas one site was left without graft. Implant stability was measured by resonance frequency analysis over 6 months. Implant success was evaluated after 2 years of loading. Volume of new endo-sinus bone was calculated from CBCT images using 3D Slicer (R) software. Results: A total of 180 implants were inserted into posterior maxilla of 45 patients with 6.59 +/- 0.45 mm of residual bone height, and all remained successful after 2 years. Implant stability steadily increased during healing, without significant difference between groups (p =.658). After 2 years, endo-sinus bone significantly shrank (p  lt .001) in all groups (DBB: 66.34%; beta-TCP: 61.44%; new bone formed from coagulum: 53.02%; beta-TCP + DBB: 33.47%). Conclusions: Endo-sinus bone gained after OSFE inevitably and significantly shrinks regardless of whether grafting material is applied or not. Grafting material offers no significant advantage to stability nor clinical success of hydrophilic and nanostructured implants placed simultaneously with OSFE.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement
VL  - 18
IS  - 5
SP  - 873
EP  - 882
DO  - 10.1111/cid.12373
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Calvo Guirado, Jose Luis and Delgado-Ruiz, Rafael and Janjić, Bojan and Abboud, Marcus",
year = "2016",
abstract = "Purpose: To evaluate stability and success rate of hydrophilic nanostructured implants placed via osteotome sinus floor elevation (OSFE) without grafting material or using beta-tricalcium phosphate (beta-TCP), deproteinized bovine bone (DBB), or their combination, and also to assess three-dimensional volumetric stability of endo-sinus bone gained in the aforementioned conditions. Materials and Methods: OSFE with simultaneous implant placement (10-mm long SLActive-BL (R), Straumann, Basel, Switzerland) was performed. Grafting materials were randomly allocated to implant sites, whereas one site was left without graft. Implant stability was measured by resonance frequency analysis over 6 months. Implant success was evaluated after 2 years of loading. Volume of new endo-sinus bone was calculated from CBCT images using 3D Slicer (R) software. Results: A total of 180 implants were inserted into posterior maxilla of 45 patients with 6.59 +/- 0.45 mm of residual bone height, and all remained successful after 2 years. Implant stability steadily increased during healing, without significant difference between groups (p =.658). After 2 years, endo-sinus bone significantly shrank (p  lt .001) in all groups (DBB: 66.34%; beta-TCP: 61.44%; new bone formed from coagulum: 53.02%; beta-TCP + DBB: 33.47%). Conclusions: Endo-sinus bone gained after OSFE inevitably and significantly shrinks regardless of whether grafting material is applied or not. Grafting material offers no significant advantage to stability nor clinical success of hydrophilic and nanostructured implants placed simultaneously with OSFE.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement",
volume = "18",
number = "5",
pages = "873-882",
doi = "10.1111/cid.12373"
}

Marković, A., Mišić, T., Calvo Guirado, J. L., Delgado-Ruiz, R., Janjić, B.,& Abboud, M.. (2016). Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 18(5), 873-882.
https://doi.org/10.1111/cid.12373

Marković A, Mišić T, Calvo Guirado JL, Delgado-Ruiz R, Janjić B, Abboud M. Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement. in Clinical Implant Dentistry & Related Research. 2016;18(5):873-882.
doi:10.1111/cid.12373 .

Marković, Aleksa, Mišić, Tijana, Calvo Guirado, Jose Luis, Delgado-Ruiz, Rafael, Janjić, Bojan, Abboud, Marcus, "Two-Center Prospective, Randomized, Clinical, and Radiographic Study Comparing Osteotome Sinus Floor Elevation with or without Bone Graft and Simultaneous Implant Placement" in Clinical Implant Dentistry & Related Research, 18, no. 5 (2016):873-882,
https://doi.org/10.1111/cid.12373 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Gomez-Moreno, Gerardo
AU  - Aguilar-Salvatierra, Antonio
AU  - Marković, Aleksa
AU  - Eduardo Mate-Sanchez, Jose
AU  - Calvo Guirado, Jose Luis
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2125
AB  - ObjectivesTo measure the lateral surface area of microgrooved zirconia implants, to evaluate the cell geometry and cell density of human fetal osteoblasts seeded on zirconia microgrooved implants, to describe the surface roughness and chemistry, and to evaluate the activity of human fetal osteoblasts seeded on zirconia microgrooved disks. Materials and methodsThis experimental in vitro study used 62 zirconia implants and 130 zirconia disks. Two experimental groups were created for the implants: 31 non-microgrooved implants (Control) and 31 microgrooved implants (Test); two experimental groups were created for the disks: 65 non-microgrooved disks (Control) and 65 microgrooved disks (Test). The following evaluations of the implants were made: lateral surface area (LSA), cell morphology, and density of human fetal osteoblasts seeded on implant surfaces. On the disks, surface parameters (roughness and chemistry) and cell activity (alkaline phosphatase - ALP and alizarin red - ALZ) were evaluated at 7 and 15days. ResultsLSA was lower for control implants (62.8mm) compared with test implants (128.74mm) (P lt 0.05). Cell bodies on control surfaces were flattened and disorganized, while in the test group, they were aligned inside the microgrooves. Control group cells showed few lamellipodia, which were attached mainly inside topographical accidents (surface cracks, valleys, and pits). Test group implants presented cells rich in lamellipodia prolongations, attached to the inner walls or to the borders of the microgrooves and in the flat areas between the microgrooves. Cell density was higher in the test group compared with controls (P lt 0.05) Surface roughness and oxygen content increased in test disks samples compared with controls (P lt 0.05). Carbon and aluminum were reduced in disks test samples compared with controls (P lt 0.05), and ALP and ALZ levels were significantly increased on test surfaces (P lt 0.05) at both study times. ConclusionsWithin the limitations of this experimental study, it may be concluded that (i) Roughness is increased and chemical composition enhanced on the surface of zirconia implants with microgrooves. (ii) The LSA of microgrooved zirconia implants is greater and provides more available surface compared with implants of the same dimensions without microgrooves. (iii) Microgrooves on zirconia implants modify the morphology and guide the size and alignment of human fetal osteoblasts. (iv) Zirconia surfaces with microgrooves of 30m width and 70m separation between grooves enhance ALP and ALZ expression by human fetal osteoblasts.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study
VL  - 27
IS  - 11
SP  - e144
EP  - e153
DO  - 10.1111/clr.12585
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Gomez-Moreno, Gerardo and Aguilar-Salvatierra, Antonio and Marković, Aleksa and Eduardo Mate-Sanchez, Jose and Calvo Guirado, Jose Luis",
year = "2016",
abstract = "ObjectivesTo measure the lateral surface area of microgrooved zirconia implants, to evaluate the cell geometry and cell density of human fetal osteoblasts seeded on zirconia microgrooved implants, to describe the surface roughness and chemistry, and to evaluate the activity of human fetal osteoblasts seeded on zirconia microgrooved disks. Materials and methodsThis experimental in vitro study used 62 zirconia implants and 130 zirconia disks. Two experimental groups were created for the implants: 31 non-microgrooved implants (Control) and 31 microgrooved implants (Test); two experimental groups were created for the disks: 65 non-microgrooved disks (Control) and 65 microgrooved disks (Test). The following evaluations of the implants were made: lateral surface area (LSA), cell morphology, and density of human fetal osteoblasts seeded on implant surfaces. On the disks, surface parameters (roughness and chemistry) and cell activity (alkaline phosphatase - ALP and alizarin red - ALZ) were evaluated at 7 and 15days. ResultsLSA was lower for control implants (62.8mm) compared with test implants (128.74mm) (P lt 0.05). Cell bodies on control surfaces were flattened and disorganized, while in the test group, they were aligned inside the microgrooves. Control group cells showed few lamellipodia, which were attached mainly inside topographical accidents (surface cracks, valleys, and pits). Test group implants presented cells rich in lamellipodia prolongations, attached to the inner walls or to the borders of the microgrooves and in the flat areas between the microgrooves. Cell density was higher in the test group compared with controls (P lt 0.05) Surface roughness and oxygen content increased in test disks samples compared with controls (P lt 0.05). Carbon and aluminum were reduced in disks test samples compared with controls (P lt 0.05), and ALP and ALZ levels were significantly increased on test surfaces (P lt 0.05) at both study times. ConclusionsWithin the limitations of this experimental study, it may be concluded that (i) Roughness is increased and chemical composition enhanced on the surface of zirconia implants with microgrooves. (ii) The LSA of microgrooved zirconia implants is greater and provides more available surface compared with implants of the same dimensions without microgrooves. (iii) Microgrooves on zirconia implants modify the morphology and guide the size and alignment of human fetal osteoblasts. (iv) Zirconia surfaces with microgrooves of 30m width and 70m separation between grooves enhance ALP and ALZ expression by human fetal osteoblasts.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study",
volume = "27",
number = "11",
pages = "e144-e153",
doi = "10.1111/clr.12585"
}

Delgado-Ruiz, R., Gomez-Moreno, G., Aguilar-Salvatierra, A., Marković, A., Eduardo Mate-Sanchez, J.,& Calvo Guirado, J. L.. (2016). Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study. in Clinical Oral Implants Research
Wiley, Hoboken., 27(11), e144-e153.
https://doi.org/10.1111/clr.12585

Delgado-Ruiz R, Gomez-Moreno G, Aguilar-Salvatierra A, Marković A, Eduardo Mate-Sanchez J, Calvo Guirado JL. Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study. in Clinical Oral Implants Research. 2016;27(11):e144-e153.
doi:10.1111/clr.12585 .

Delgado-Ruiz, Rafael, Gomez-Moreno, Gerardo, Aguilar-Salvatierra, Antonio, Marković, Aleksa, Eduardo Mate-Sanchez, Jose, Calvo Guirado, Jose Luis, "Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimental in vitro study" in Clinical Oral Implants Research, 27, no. 11 (2016):e144-e153,
https://doi.org/10.1111/clr.12585 . .

TY  - JOUR
AU  - Pejović, Marko
AU  - Stepić, Jelena
AU  - Marković, Aleksa
AU  - Dragović, Miroslav
AU  - Miličić, Biljana
AU  - Čolić, Snježana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2117
AB  - Background/Aim. Surgical treatment of odontogenic cysts in childhood could be accompanied by injury of important anatomical structures. Even though enucleation is considered to be preferable treatment of odontogenic cysts, the specificities of pediatric age favor more conservative surgical approach. The aim of this study was to assess the effectiveness of decompression as the uttermost treatment of odontogenic cysts in the pediatric age. Methods. This retrospective study included 22 patients, 7-16 years old, with a single jaw cystic lesion. The majority of these lesions were dentigerous cyst (14), and the rest belonged to keratocystic odontogenic tumor (KCOT) (8). All lesions were primarily treated with decompression; it was a final treatment (one-stage procedure) in 13 dentigerous cysts, and it was followed by enucleation (two-stage procedure) in one dentigerous cyst and all the KCOT. Results. A total of 13 (59.1%) dentigerous cysts were treated successfully only with decompression as one stage procedure, while the other 9 (40.9%) cysts required enucleation (1 dentigerous and 8 KCOT), after decompression (p ≤ 0.001). Conclusion. Related to non-aggressive lesions, more conservative treatment approach, such as decompression as one-stage procedure, should be considered. On the other hand, KCOTs in children require a two-stage procedure for a successful treatment outcome.
AB  - Uvod/Cilj. Hirurška terapija odontogenih cista u dečjem uzrastu može da bude udružena sa povredama važnih anatomskih struktura. Mada se enukleacija smatra terapijom izbora viličnih cista, specifičnosti dečjeg uzrasta nameću primenu konzervativnijeg hirurškog pristupa. Cilj istraživanja bio je da se proceni efikasnost dekompresije kao definitivnog terapijskog modaliteta kod odontogenih cista u dečjem uzrastu. Metode. Ova retrospektivna studija obuhvatila je 22 pacijenta, uzrasta 7-16 godina, sa solitarnim cističnim lezijama. Najčešće među njima su bile folikularne ciste (14), a ostale su bile keratocistični odontogeni tumori (KCOT). Sve cistične lezije prvo su tretirane dekompresijom; to je bio i jedini poduhvat (jednofazni postupak) kod 13 folikularnih cista, a potreba za sekundarnim zahvatom - enukleacijom, ukazala se posle dekompresije jedne folikularne ciste i svih KCOT (dvofazni postupak). Rezultati. Ukupno 13 (59,1%) cističnih lezija, od kojih su sve bile folikularne ciste, uspešno je podvrgnuto jednofaznom hirurškom postupku, dok je preostalih 9 (40,9%) cista (1 folikularna i 8 KCOT) zahtevalo naknadnu enukleaciju. Zaključak. Kod neagresivnih cističnih lezija preporučuje se konzervativniji hirurški pristup kao što je dekompresija (jednofazna procedura). Nasuprot tome, KCOT u dečjem uzrastu zahtevaju dvofazni hirurški postupak - dekompresiju praćenu enukleacijom.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Retrospective study of spontaneous bone regeneration after decompression of large odontogenic cystic lesions in children
T1  - Retrospetkivna studija spontane regeneracije kosti posle dekompresije velikih odontogenih cističnih lezija kod dece
VL  - 73
IS  - 2
SP  - 129
EP  - 134
DO  - 10.2298/VSP140828147P
ER  - 

@article{
author = "Pejović, Marko and Stepić, Jelena and Marković, Aleksa and Dragović, Miroslav and Miličić, Biljana and Čolić, Snježana",
year = "2016",
abstract = "Background/Aim. Surgical treatment of odontogenic cysts in childhood could be accompanied by injury of important anatomical structures. Even though enucleation is considered to be preferable treatment of odontogenic cysts, the specificities of pediatric age favor more conservative surgical approach. The aim of this study was to assess the effectiveness of decompression as the uttermost treatment of odontogenic cysts in the pediatric age. Methods. This retrospective study included 22 patients, 7-16 years old, with a single jaw cystic lesion. The majority of these lesions were dentigerous cyst (14), and the rest belonged to keratocystic odontogenic tumor (KCOT) (8). All lesions were primarily treated with decompression; it was a final treatment (one-stage procedure) in 13 dentigerous cysts, and it was followed by enucleation (two-stage procedure) in one dentigerous cyst and all the KCOT. Results. A total of 13 (59.1%) dentigerous cysts were treated successfully only with decompression as one stage procedure, while the other 9 (40.9%) cysts required enucleation (1 dentigerous and 8 KCOT), after decompression (p ≤ 0.001). Conclusion. Related to non-aggressive lesions, more conservative treatment approach, such as decompression as one-stage procedure, should be considered. On the other hand, KCOTs in children require a two-stage procedure for a successful treatment outcome., Uvod/Cilj. Hirurška terapija odontogenih cista u dečjem uzrastu može da bude udružena sa povredama važnih anatomskih struktura. Mada se enukleacija smatra terapijom izbora viličnih cista, specifičnosti dečjeg uzrasta nameću primenu konzervativnijeg hirurškog pristupa. Cilj istraživanja bio je da se proceni efikasnost dekompresije kao definitivnog terapijskog modaliteta kod odontogenih cista u dečjem uzrastu. Metode. Ova retrospektivna studija obuhvatila je 22 pacijenta, uzrasta 7-16 godina, sa solitarnim cističnim lezijama. Najčešće među njima su bile folikularne ciste (14), a ostale su bile keratocistični odontogeni tumori (KCOT). Sve cistične lezije prvo su tretirane dekompresijom; to je bio i jedini poduhvat (jednofazni postupak) kod 13 folikularnih cista, a potreba za sekundarnim zahvatom - enukleacijom, ukazala se posle dekompresije jedne folikularne ciste i svih KCOT (dvofazni postupak). Rezultati. Ukupno 13 (59,1%) cističnih lezija, od kojih su sve bile folikularne ciste, uspešno je podvrgnuto jednofaznom hirurškom postupku, dok je preostalih 9 (40,9%) cista (1 folikularna i 8 KCOT) zahtevalo naknadnu enukleaciju. Zaključak. Kod neagresivnih cističnih lezija preporučuje se konzervativniji hirurški pristup kao što je dekompresija (jednofazna procedura). Nasuprot tome, KCOT u dečjem uzrastu zahtevaju dvofazni hirurški postupak - dekompresiju praćenu enukleacijom.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Retrospective study of spontaneous bone regeneration after decompression of large odontogenic cystic lesions in children, Retrospetkivna studija spontane regeneracije kosti posle dekompresije velikih odontogenih cističnih lezija kod dece",
volume = "73",
number = "2",
pages = "129-134",
doi = "10.2298/VSP140828147P"
}

Pejović, M., Stepić, J., Marković, A., Dragović, M., Miličić, B.,& Čolić, S.. (2016). Retrospective study of spontaneous bone regeneration after decompression of large odontogenic cystic lesions in children. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(2), 129-134.
https://doi.org/10.2298/VSP140828147P

Pejović M, Stepić J, Marković A, Dragović M, Miličić B, Čolić S. Retrospective study of spontaneous bone regeneration after decompression of large odontogenic cystic lesions in children. in Vojnosanitetski pregled. 2016;73(2):129-134.
doi:10.2298/VSP140828147P .

Pejović, Marko, Stepić, Jelena, Marković, Aleksa, Dragović, Miroslav, Miličić, Biljana, Čolić, Snježana, "Retrospective study of spontaneous bone regeneration after decompression of large odontogenic cystic lesions in children" in Vojnosanitetski pregled, 73, no. 2 (2016):129-134,
https://doi.org/10.2298/VSP140828147P . .

TY  - JOUR
AU  - Gomez-Moreno, Gerardo
AU  - Aguilar-Salvatierra, Antonio
AU  - Fernandez-Cejas, Esther
AU  - Arcesio Delgado-Ruiz, Rafael
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2088
AB  - Objectives: The aim of this study was to evaluate the incidence of bleeding complications after dental implant placement in patients in treatment by the anticoagulant oral rivaroxaban without interrupting its administration or modifying dosage. Materials and methods: About 57 patients were divided into two groups: 18 had been in treatment by rivaroxaban for over 6 month before implant surgery and a control group consisted of 39 healthy subjects. All subjects received dental implants in different positions, without interrupting or modifying rivaroxaban dosage. Patients were treated in an outpatient setting. Non-absorbable sutures were used, and all patients were given gauze impregnated with tranexamic acid 5%, to bite on for 30 60 min. Results: One rivaroxaban patient presented moderate bleeding the day after surgery, and two control patients presented moderate bleeding the day after and on the second day. Bleeding was managed with gauzes impregnated with tranexamic acid. No statistically significant differences (P 0.688) were found in relation to bleeding episodes between the groups, with a relative risk 0.919 based on the pooled groups and 95% confidence interval of 0.078 10.844. Conclusions: Dental implant surgery in patients taking the anticoagulant oral rivaroxaban can be performed safely in outpatients departments applying local hemostatic measures without the need to modify or interrupt anticoagulant medication.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban
VL  - 27
IS  - 6
SP  - 730
EP  - 733
DO  - 10.1111/clr.12653
ER  - 

@article{
author = "Gomez-Moreno, Gerardo and Aguilar-Salvatierra, Antonio and Fernandez-Cejas, Esther and Arcesio Delgado-Ruiz, Rafael and Marković, Aleksa and Calvo Guirado, Jose Luis",
year = "2016",
abstract = "Objectives: The aim of this study was to evaluate the incidence of bleeding complications after dental implant placement in patients in treatment by the anticoagulant oral rivaroxaban without interrupting its administration or modifying dosage. Materials and methods: About 57 patients were divided into two groups: 18 had been in treatment by rivaroxaban for over 6 month before implant surgery and a control group consisted of 39 healthy subjects. All subjects received dental implants in different positions, without interrupting or modifying rivaroxaban dosage. Patients were treated in an outpatient setting. Non-absorbable sutures were used, and all patients were given gauze impregnated with tranexamic acid 5%, to bite on for 30 60 min. Results: One rivaroxaban patient presented moderate bleeding the day after surgery, and two control patients presented moderate bleeding the day after and on the second day. Bleeding was managed with gauzes impregnated with tranexamic acid. No statistically significant differences (P 0.688) were found in relation to bleeding episodes between the groups, with a relative risk 0.919 based on the pooled groups and 95% confidence interval of 0.078 10.844. Conclusions: Dental implant surgery in patients taking the anticoagulant oral rivaroxaban can be performed safely in outpatients departments applying local hemostatic measures without the need to modify or interrupt anticoagulant medication.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban",
volume = "27",
number = "6",
pages = "730-733",
doi = "10.1111/clr.12653"
}

Gomez-Moreno, G., Aguilar-Salvatierra, A., Fernandez-Cejas, E., Arcesio Delgado-Ruiz, R., Marković, A.,& Calvo Guirado, J. L.. (2016). Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban. in Clinical Oral Implants Research
Wiley, Hoboken., 27(6), 730-733.
https://doi.org/10.1111/clr.12653

Gomez-Moreno G, Aguilar-Salvatierra A, Fernandez-Cejas E, Arcesio Delgado-Ruiz R, Marković A, Calvo Guirado JL. Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban. in Clinical Oral Implants Research. 2016;27(6):730-733.
doi:10.1111/clr.12653 .

Gomez-Moreno, Gerardo, Aguilar-Salvatierra, Antonio, Fernandez-Cejas, Esther, Arcesio Delgado-Ruiz, Rafael, Marković, Aleksa, Calvo Guirado, Jose Luis, "Dental implant surgery in patients in treatment with the anticoagulant oral rivaroxaban" in Clinical Oral Implants Research, 27, no. 6 (2016):730-733,
https://doi.org/10.1111/clr.12653 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Lazić, Zoran
AU  - Mišić, Tijana
AU  - Šćepanović, Miodrag
AU  - Todorović, Aleksandar
AU  - Thakare, Kaustubh
AU  - Janjić, Bojan
AU  - Vlahović, Zoran
AU  - Glišić, Mirko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2081
AB  - Background/Aim. During drilling implant sites, mechanical energy is converted into thermal one resulting in transient rise in temperature of surrounding bone. The temperature of 47°C exeeding one minute impairs osseointegration, compromises mechanical properties of the local bone and could cause early implant failure. This in vitro study aimed to assess the effect of surgical drill guide and temperature of irrigans on thermal changes of the local bone during drilling implant sites, and to test the influence of irrigans temperature on the temperature of surgical drill guide. Methods. A total of 48 specimens obtained from bovine ribs were randomly allocated to four experimental conditions according to the 2 x 2 factorial design: drill guide (with or without) and saline (at 25°C or 5°C). Real-time infrared thermography was used as a method for temperature measurement. The primary outcome was bone temperature change during drilling implant sites measured at 3 osteotomy depths, whereas the second one was change in the temperature of the drill guide. Data were analyzed by Brunner and Langer nonparametric analysis and Wilcoxon test. Results. The effect of drill guide on the changes of bone temperature was significant at the entrance of osteotomy, whereas the effect of saline temperature was significant at all osteotomy levels (p  lt  0.001). No significant interaction was found (p > 0.05). Guided surgery and irrigation with saline at 25°C were associated with the highest bone temperature increase. Increase in drill guide temperature was significantly higher when saline at 25°C was used (p  lt  0.001). Conclusion. Guided implant site preparation generates higher temperature of the local bone than conventional drilling, not exceeding the threshold for thermal bone necrosis. Although saline at room temperature provides sufficient heat control during drilling, cooled saline is more effective regardless the use of surgical drill guide.
AB  - Uvod/Cilj. Tokom preparacije ležišta za implantat mehanička energija pretvara se u toplotnu, što dovodi do prolaznog povišenja temperature okolne kosti. Temperatura od 47°C tokom više od jednog minuta narušava oseointegraciju, mehaničke osobine lokalne kosti i može dovesti do ranog neuspeha implantata. Cilj ove in vitro studije bio je da se ispita uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta za implantat, kao i uticaj temperature irigansa na temperaturu hirurškog stenta. Metode. Ukupno 48 uzoraka dobijenih od goveđih rebara bilo je podeljeno metodom slučajnog izbora u četiri grupe prema 2 x 2 faktorskom dizajnu: prisustvo hirurškog stenta (da/ne) i temperatura fiziološkog rastvora (25°C/5°C). Temperatura je merena infracrvenom termografijom u realnom vremenu. Primarni ishod bio je promena temperature kosti tokom preparacije ležišta implantata merena na tri dubine ležišta, a sekundarni ishod promena temperature hirurškog stenta. Podaci su analizirani Bruner-Langer neparametrijskom analizom i Vilkoksonovim testom. Rezultati. Uticaj hirurškog stenta na promenutemperature kosti bio je značajan na ulazu u ležište za implantat, dok je uticaj temperature irigansa bio značajan na svim dubinama ležišta (p  lt  0,001). Međusobni uticaj ispitivanih faktora nije bio značajan (p > 0,05). Upotreba hirurškog stenta i ispiranje fiziološkim rastvorom temperature 25°C bili su praćeni najvišim porastom temperature kosti. Porast temperature hirurškog stenta bio je značajno viši kada je korišćeno ispiranje na temperaturi od 25°C (p  lt  0,001). Zaključak. Tokom kontrolisane preparacije ležišta za implantat došlo je do većeg zagrevanja kosti u poređenju sa standardnom preparacijom, ne premašujući temperaturu kritičnu za termičku nekrozu kosti. Iako ispiranje na sobnoj temperaturi obezbeđuje dovoljno hlađenja kosti tokom preparacije ležišta za implantat, ohlađeni rastvor za ispiranje je efikasniji bez obzira na primenu hirurškog stenta.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs
T1  - Uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta implantata - termografska analiza na goveđim rebrima
VL  - 73
IS  - 8
SP  - 744
EP  - 750
DO  - 10.2298/VSP141208041M
ER  - 

@article{
author = "Marković, Aleksa and Lazić, Zoran and Mišić, Tijana and Šćepanović, Miodrag and Todorović, Aleksandar and Thakare, Kaustubh and Janjić, Bojan and Vlahović, Zoran and Glišić, Mirko",
year = "2016",
abstract = "Background/Aim. During drilling implant sites, mechanical energy is converted into thermal one resulting in transient rise in temperature of surrounding bone. The temperature of 47°C exeeding one minute impairs osseointegration, compromises mechanical properties of the local bone and could cause early implant failure. This in vitro study aimed to assess the effect of surgical drill guide and temperature of irrigans on thermal changes of the local bone during drilling implant sites, and to test the influence of irrigans temperature on the temperature of surgical drill guide. Methods. A total of 48 specimens obtained from bovine ribs were randomly allocated to four experimental conditions according to the 2 x 2 factorial design: drill guide (with or without) and saline (at 25°C or 5°C). Real-time infrared thermography was used as a method for temperature measurement. The primary outcome was bone temperature change during drilling implant sites measured at 3 osteotomy depths, whereas the second one was change in the temperature of the drill guide. Data were analyzed by Brunner and Langer nonparametric analysis and Wilcoxon test. Results. The effect of drill guide on the changes of bone temperature was significant at the entrance of osteotomy, whereas the effect of saline temperature was significant at all osteotomy levels (p  lt  0.001). No significant interaction was found (p > 0.05). Guided surgery and irrigation with saline at 25°C were associated with the highest bone temperature increase. Increase in drill guide temperature was significantly higher when saline at 25°C was used (p  lt  0.001). Conclusion. Guided implant site preparation generates higher temperature of the local bone than conventional drilling, not exceeding the threshold for thermal bone necrosis. Although saline at room temperature provides sufficient heat control during drilling, cooled saline is more effective regardless the use of surgical drill guide., Uvod/Cilj. Tokom preparacije ležišta za implantat mehanička energija pretvara se u toplotnu, što dovodi do prolaznog povišenja temperature okolne kosti. Temperatura od 47°C tokom više od jednog minuta narušava oseointegraciju, mehaničke osobine lokalne kosti i može dovesti do ranog neuspeha implantata. Cilj ove in vitro studije bio je da se ispita uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta za implantat, kao i uticaj temperature irigansa na temperaturu hirurškog stenta. Metode. Ukupno 48 uzoraka dobijenih od goveđih rebara bilo je podeljeno metodom slučajnog izbora u četiri grupe prema 2 x 2 faktorskom dizajnu: prisustvo hirurškog stenta (da/ne) i temperatura fiziološkog rastvora (25°C/5°C). Temperatura je merena infracrvenom termografijom u realnom vremenu. Primarni ishod bio je promena temperature kosti tokom preparacije ležišta implantata merena na tri dubine ležišta, a sekundarni ishod promena temperature hirurškog stenta. Podaci su analizirani Bruner-Langer neparametrijskom analizom i Vilkoksonovim testom. Rezultati. Uticaj hirurškog stenta na promenutemperature kosti bio je značajan na ulazu u ležište za implantat, dok je uticaj temperature irigansa bio značajan na svim dubinama ležišta (p  lt  0,001). Međusobni uticaj ispitivanih faktora nije bio značajan (p > 0,05). Upotreba hirurškog stenta i ispiranje fiziološkim rastvorom temperature 25°C bili su praćeni najvišim porastom temperature kosti. Porast temperature hirurškog stenta bio je značajno viši kada je korišćeno ispiranje na temperaturi od 25°C (p  lt  0,001). Zaključak. Tokom kontrolisane preparacije ležišta za implantat došlo je do većeg zagrevanja kosti u poređenju sa standardnom preparacijom, ne premašujući temperaturu kritičnu za termičku nekrozu kosti. Iako ispiranje na sobnoj temperaturi obezbeđuje dovoljno hlađenja kosti tokom preparacije ležišta za implantat, ohlađeni rastvor za ispiranje je efikasniji bez obzira na primenu hirurškog stenta.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs, Uticaj hirurškog stenta i temperature irigansa na termičke promene u kosti tokom preparacije ležišta implantata - termografska analiza na goveđim rebrima",
volume = "73",
number = "8",
pages = "744-750",
doi = "10.2298/VSP141208041M"
}

Marković, A., Lazić, Z., Mišić, T., Šćepanović, M., Todorović, A., Thakare, K., Janjić, B., Vlahović, Z.,& Glišić, M.. (2016). Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(8), 744-750.
https://doi.org/10.2298/VSP141208041M

Marković A, Lazić Z, Mišić T, Šćepanović M, Todorović A, Thakare K, Janjić B, Vlahović Z, Glišić M. Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs. in Vojnosanitetski pregled. 2016;73(8):744-750.
doi:10.2298/VSP141208041M .

Marković, Aleksa, Lazić, Zoran, Mišić, Tijana, Šćepanović, Miodrag, Todorović, Aleksandar, Thakare, Kaustubh, Janjić, Bojan, Vlahović, Zoran, Glišić, Mirko, "Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites: Thermographic analysis on bovine ribs" in Vojnosanitetski pregled, 73, no. 8 (2016):744-750,
https://doi.org/10.2298/VSP141208041M . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2070
AB  - Implant placement in the esthetic zone is a complex procedure and requires a restoration-driven approach. Proper selection of patients and implant together with individual assessment of the risk of esthetic complications are very important. Correct 3D-implant positioning and sufficient bone volume should provide long-term esthetic and function. Esthetic region is a zone in which expectations and possibilities collide. Clinician should bring the important decision on the appropriate time of implant placement. Immediate implant placement is particularly challenging in the esthetic zone. Patient desire for reduced treatment time should be weighed against the possible risk factors. Protocol of immediate implant placement in conditions of unfavourable gingival biotypes, the lack of bone or soft tissue in patients with a high smile line lead to esthetic failure which is very important in the esthetic region.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Implant therapy in the esthetic zone-surgical considerations
VL  - 20
IS  - 2
SP  - 83
EP  - 88
DO  - 10.1515/bjdm-2016-0013
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana",
year = "2016",
abstract = "Implant placement in the esthetic zone is a complex procedure and requires a restoration-driven approach. Proper selection of patients and implant together with individual assessment of the risk of esthetic complications are very important. Correct 3D-implant positioning and sufficient bone volume should provide long-term esthetic and function. Esthetic region is a zone in which expectations and possibilities collide. Clinician should bring the important decision on the appropriate time of implant placement. Immediate implant placement is particularly challenging in the esthetic zone. Patient desire for reduced treatment time should be weighed against the possible risk factors. Protocol of immediate implant placement in conditions of unfavourable gingival biotypes, the lack of bone or soft tissue in patients with a high smile line lead to esthetic failure which is very important in the esthetic region.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Implant therapy in the esthetic zone-surgical considerations",
volume = "20",
number = "2",
pages = "83-88",
doi = "10.1515/bjdm-2016-0013"
}

Marković, A.,& Mišić, T.. (2016). Implant therapy in the esthetic zone-surgical considerations. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 20(2), 83-88.
https://doi.org/10.1515/bjdm-2016-0013

Marković A, Mišić T. Implant therapy in the esthetic zone-surgical considerations. in Balkan Journal of Dental Medicine. 2016;20(2):83-88.
doi:10.1515/bjdm-2016-0013 .

Marković, Aleksa, Mišić, Tijana, "Implant therapy in the esthetic zone-surgical considerations" in Balkan Journal of Dental Medicine, 20, no. 2 (2016):83-88,
https://doi.org/10.1515/bjdm-2016-0013 . .

TY  - JOUR
AU  - Tanasić, Ivan
AU  - Tihaček-Šojić, Ljiljana
AU  - Mitrović, Nenad
AU  - Milić-Lemić, Aleksandra
AU  - Vukadinović, Miroslav
AU  - Marković, Aleksa
AU  - Milošević, Miloš
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1965
AB  - The aim of this study was to determine, evaluate and measure strain of vertically loaded implant using the digital image correlation method. The Straumann (R) dental implant system with the SLActive (R) surface was used in this study. Implant was immersed in poly-methyl-methacrylate during his hardening process. After preparation procedure a sample of implant and poly-methyl-methacrylate was obtained. This sample was loaded using external load from 0 to 400 N. Maximum strain in the 4 mm surface layer was 0.30% whereas maximum strain in the 6 mm surface layer (opposite side) was 0.20%, detected in the marginal and apical part of implant-poly-methyl-methacrylate sample. Minimum strain measured by Aramis software was 0.01%, detected in the 4 mm surface layer. According to results obtained by Aramis data processing, the 4 mm surface layer indicated higher overall strain in apical direction with the strains of 0.18-0.21%. Increasing the load did not affect the value of maximum strain however, higher load influenced the overall strain concentration increased especially in marginal and apical part of the sample surfaces that surrounded lateral sides of implant body.
PB  - Elsevier Sci Ltd, Oxford
T2  - Measurement
T1  - An attempt to create a standardized (reference) model for experimental investigations on implant's sample
VL  - 72
SP  - 37
EP  - 42
DO  - 10.1016/j.measurement.2015.04.029
ER  - 

@article{
author = "Tanasić, Ivan and Tihaček-Šojić, Ljiljana and Mitrović, Nenad and Milić-Lemić, Aleksandra and Vukadinović, Miroslav and Marković, Aleksa and Milošević, Miloš",
year = "2015",
abstract = "The aim of this study was to determine, evaluate and measure strain of vertically loaded implant using the digital image correlation method. The Straumann (R) dental implant system with the SLActive (R) surface was used in this study. Implant was immersed in poly-methyl-methacrylate during his hardening process. After preparation procedure a sample of implant and poly-methyl-methacrylate was obtained. This sample was loaded using external load from 0 to 400 N. Maximum strain in the 4 mm surface layer was 0.30% whereas maximum strain in the 6 mm surface layer (opposite side) was 0.20%, detected in the marginal and apical part of implant-poly-methyl-methacrylate sample. Minimum strain measured by Aramis software was 0.01%, detected in the 4 mm surface layer. According to results obtained by Aramis data processing, the 4 mm surface layer indicated higher overall strain in apical direction with the strains of 0.18-0.21%. Increasing the load did not affect the value of maximum strain however, higher load influenced the overall strain concentration increased especially in marginal and apical part of the sample surfaces that surrounded lateral sides of implant body.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Measurement",
title = "An attempt to create a standardized (reference) model for experimental investigations on implant's sample",
volume = "72",
pages = "37-42",
doi = "10.1016/j.measurement.2015.04.029"
}

Tanasić, I., Tihaček-Šojić, L., Mitrović, N., Milić-Lemić, A., Vukadinović, M., Marković, A.,& Milošević, M.. (2015). An attempt to create a standardized (reference) model for experimental investigations on implant's sample. in Measurement
Elsevier Sci Ltd, Oxford., 72, 37-42.
https://doi.org/10.1016/j.measurement.2015.04.029

Tanasić I, Tihaček-Šojić L, Mitrović N, Milić-Lemić A, Vukadinović M, Marković A, Milošević M. An attempt to create a standardized (reference) model for experimental investigations on implant's sample. in Measurement. 2015;72:37-42.
doi:10.1016/j.measurement.2015.04.029 .

Tanasić, Ivan, Tihaček-Šojić, Ljiljana, Mitrović, Nenad, Milić-Lemić, Aleksandra, Vukadinović, Miroslav, Marković, Aleksa, Milošević, Miloš, "An attempt to create a standardized (reference) model for experimental investigations on implant's sample" in Measurement, 72 (2015):37-42,
https://doi.org/10.1016/j.measurement.2015.04.029 . .

TY  - JOUR
AU  - Mandić, Borka
AU  - Lazić, Zoran
AU  - Marković, Aleksa
AU  - Mandić, Bojan
AU  - Mandić, Miška
AU  - Đinić, Ana
AU  - Miličić, Biljana
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2020
AB  - Background/Aim. Low-level laser therapy (LLLT) has been proven to stimulate bone repair, affecting cellular proliferation, differentiation and adhesion, and has shown a potential to reduce the healing time following implant placement. The aim of this clinical study was to investigate the influence of postoperative LLLT osseointegration and early success of self-tapping implants placed into low-density bone. Methods. Following the split-mouth design, self-tapping implants (n = 44) were inserted in the posterior maxilla of 12 patients. One jaw side randomly received LLLT (test group), while the other side was placebo (control group). For LLLT, a 637 nm gallium-aluminum-arsenide (GaAlAs) laser (Medicolaser 637, Technoline, Belgrade, Serbia) with an output power of 40 mW and continuous wave was used. Low-level laser treatment was performed immediately after the surgery and then repeated every day in the following 7 days. The total irradiation dose per treatment was 6.26 J/cm² per implant. The study outcomes were: implant stability, alkaline-phosphatase (ALP) activity and early implant success rate. The follow-up took 6 weeks. Results. Irradiated implants achieved a higher stability compared with controls during the entire follow-up and the difference reached significance in the 5th postoperative week (paired t-test, p = 0.030). The difference in ALP activ- ity between the groups was insignificant in any observation point (paired t-test, p > 0.05). The early implant success rate was 100%, regardless of LLLT usage. Conclusion. LLLT applied daily during the first postoperative week expressed no significant influence on the osseointegration of self- tapping implants placed into low density bone of the posterior maxilla. Placement of self-tapping macro-designed implants into low density bone could be a predictable therapeutic procedure with a high early success rate regardless of LLLT usage.
AB  - Uvod/Cilj. Terapija laserom male snage (TLMS) stimuliše reparatorne sposobnosti kosti utičući na ćelijsku proliferaciju, diferencijaciju i adheziju, i ima potencijal da skrati vreme zarastanja kosti nakon ugradnje implantata. Cilj ove kliničke studije bio je da se ispita uticaj postoperativne primene TLMS na oseointegraciju i rani uspeh ugradnje samourezujućih implantata u kost male gustine. Metode. Prateći split- mouth dizajn, samourezujući implantati (n = 44) ugrađeni su u posteriorne regije gornje vilice 12 pacijenata. Slučajnim izborom, jednoj od strana vilice je dodeljena TLMS (test grupa), dok je druga strana bila placebo (kontrolna grupa). Za TLMS korišćen je galijum-aluminijum-arsenid (GaAlAs) laser (Medicolaser 637, Technoline, Beograd, Srbija) talasne dužine 637 nm, snage 40 mW, neprekidnog režima rada. Tretman laserom male snage sprovodio se neposredno po ugradnji, a zatim svakodnevno, tokom narednih sedam dana. Ukupna zračna doza po tretmanu bila je 6,26 J/cm² po implantatu. Praćeni su stabilnost implantata, aktivnost alkalne fosfataze (ALP) i procenat rane uspešnosti implantatne terapije. Period praćenja bio je šest nedelja. Rezultati. Zračeni implantati imali su veću stabilnost u odnosu na kontrolne tokom celog perioda praćenja, a statistički značajno veća stabilnost bila je u petoj postoperativnoj nedelji (t-test za vezane uzorke, p = 0.030). Razlika u aktivnosti ALP između grupa nije bila statistički značajna ni u jednoj tački posmatranja (t-test za vezane uzorke, p > 0.05). Procenat rane uspešnosti terapije implantatima bio je 100%, bez obzira na primenjenu TLMS. Zaključak. Svakodnevna primena TLMS u prvoj postoperativnoj nedelji nije pokazala značajan uticaj na oseointegraciju samourezujućih implantata u kost male gustine bočne regije gornje vilice. Primena implantata samourezujućeg makrodizajna u kosti male gustine mogla bi predstavljati predvidljivu terapijsku proceduru sa visokim procentom rane uspešnosti, bez obzira na primenjenu TLMS.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study
T1  - Uticaj postoperativne terapije laserom male snage na oseointegraciju samourezujućih implantata u bočnoj regiji gornje vilice - šestonedeljna split-mouth klinička studija
VL  - 72
IS  - 3
SP  - 233
EP  - 240
DO  - 10.2298/vsp131202075m
ER  - 

@article{
author = "Mandić, Borka and Lazić, Zoran and Marković, Aleksa and Mandić, Bojan and Mandić, Miška and Đinić, Ana and Miličić, Biljana",
year = "2015",
abstract = "Background/Aim. Low-level laser therapy (LLLT) has been proven to stimulate bone repair, affecting cellular proliferation, differentiation and adhesion, and has shown a potential to reduce the healing time following implant placement. The aim of this clinical study was to investigate the influence of postoperative LLLT osseointegration and early success of self-tapping implants placed into low-density bone. Methods. Following the split-mouth design, self-tapping implants (n = 44) were inserted in the posterior maxilla of 12 patients. One jaw side randomly received LLLT (test group), while the other side was placebo (control group). For LLLT, a 637 nm gallium-aluminum-arsenide (GaAlAs) laser (Medicolaser 637, Technoline, Belgrade, Serbia) with an output power of 40 mW and continuous wave was used. Low-level laser treatment was performed immediately after the surgery and then repeated every day in the following 7 days. The total irradiation dose per treatment was 6.26 J/cm² per implant. The study outcomes were: implant stability, alkaline-phosphatase (ALP) activity and early implant success rate. The follow-up took 6 weeks. Results. Irradiated implants achieved a higher stability compared with controls during the entire follow-up and the difference reached significance in the 5th postoperative week (paired t-test, p = 0.030). The difference in ALP activ- ity between the groups was insignificant in any observation point (paired t-test, p > 0.05). The early implant success rate was 100%, regardless of LLLT usage. Conclusion. LLLT applied daily during the first postoperative week expressed no significant influence on the osseointegration of self- tapping implants placed into low density bone of the posterior maxilla. Placement of self-tapping macro-designed implants into low density bone could be a predictable therapeutic procedure with a high early success rate regardless of LLLT usage., Uvod/Cilj. Terapija laserom male snage (TLMS) stimuliše reparatorne sposobnosti kosti utičući na ćelijsku proliferaciju, diferencijaciju i adheziju, i ima potencijal da skrati vreme zarastanja kosti nakon ugradnje implantata. Cilj ove kliničke studije bio je da se ispita uticaj postoperativne primene TLMS na oseointegraciju i rani uspeh ugradnje samourezujućih implantata u kost male gustine. Metode. Prateći split- mouth dizajn, samourezujući implantati (n = 44) ugrađeni su u posteriorne regije gornje vilice 12 pacijenata. Slučajnim izborom, jednoj od strana vilice je dodeljena TLMS (test grupa), dok je druga strana bila placebo (kontrolna grupa). Za TLMS korišćen je galijum-aluminijum-arsenid (GaAlAs) laser (Medicolaser 637, Technoline, Beograd, Srbija) talasne dužine 637 nm, snage 40 mW, neprekidnog režima rada. Tretman laserom male snage sprovodio se neposredno po ugradnji, a zatim svakodnevno, tokom narednih sedam dana. Ukupna zračna doza po tretmanu bila je 6,26 J/cm² po implantatu. Praćeni su stabilnost implantata, aktivnost alkalne fosfataze (ALP) i procenat rane uspešnosti implantatne terapije. Period praćenja bio je šest nedelja. Rezultati. Zračeni implantati imali su veću stabilnost u odnosu na kontrolne tokom celog perioda praćenja, a statistički značajno veća stabilnost bila je u petoj postoperativnoj nedelji (t-test za vezane uzorke, p = 0.030). Razlika u aktivnosti ALP između grupa nije bila statistički značajna ni u jednoj tački posmatranja (t-test za vezane uzorke, p > 0.05). Procenat rane uspešnosti terapije implantatima bio je 100%, bez obzira na primenjenu TLMS. Zaključak. Svakodnevna primena TLMS u prvoj postoperativnoj nedelji nije pokazala značajan uticaj na oseointegraciju samourezujućih implantata u kost male gustine bočne regije gornje vilice. Primena implantata samourezujućeg makrodizajna u kosti male gustine mogla bi predstavljati predvidljivu terapijsku proceduru sa visokim procentom rane uspešnosti, bez obzira na primenjenu TLMS.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study, Uticaj postoperativne terapije laserom male snage na oseointegraciju samourezujućih implantata u bočnoj regiji gornje vilice - šestonedeljna split-mouth klinička studija",
volume = "72",
number = "3",
pages = "233-240",
doi = "10.2298/vsp131202075m"
}

Mandić, B., Lazić, Z., Marković, A., Mandić, B., Mandić, M., Đinić, A.,& Miličić, B.. (2015). Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(3), 233-240.
https://doi.org/10.2298/vsp131202075m

Mandić B, Lazić Z, Marković A, Mandić B, Mandić M, Đinić A, Miličić B. Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study. in Vojnosanitetski pregled. 2015;72(3):233-240.
doi:10.2298/vsp131202075m .

Mandić, Borka, Lazić, Zoran, Marković, Aleksa, Mandić, Bojan, Mandić, Miška, Đinić, Ana, Miličić, Biljana, "Influence of postoperative low-level laser therapy on the osseointegration of self-tapping implants in the posterior maxilla: A 6-week split-mouth clinical study" in Vojnosanitetski pregled, 72, no. 3 (2015):233-240,
https://doi.org/10.2298/vsp131202075m . .

TY  - JOUR
AU  - Vlahović, Zoran
AU  - Marković, Aleksa
AU  - Golubović, Mileta
AU  - Šćepanović, Miodrag
AU  - Kalanović, Milena
AU  - Đinić, Ana
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2016
AB  - AimThe aim of this study was comparing the effect of flapless vs. flap technique of implant placement on inflammation degree of peri-implant soft tissue, through histopathological analysis. MethodThe experiment was conducted on five domestic pigs. Nine weeks after tooth extraction, implants were installed. Each animal received six implants in mandible. According to split-mouth design, randomly one side was used for flapless technique using mini-incision, while on the other side, flap was raised. After 7, 14, 21, 28, and 90days, the experimental animals were sacrificed. Samples for histopathological analyzes were taken from the buccal side of peri-implant mucosa next to the neck of implants, from three levels. The degree of inflammatory response in the peri-implant soft tissue was estimated through ordinal scores from 0 to 3. ResultsIn the flap group Score 3 indicating high degree of inflammation was present from day 7 to day 21, in contrast to flapless group where Score 3 was not recorded during the entire follow-up. Three months after implantation, there were no signs of inflammation neither around flap nor around flapless implants. ConclusionFlapless surgical implantation technique using mini-incision decreases peri-implant soft tissue inflammatory reaction compared with flap surgery.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Histopathological comparative analysis of peri-implant soft tissue response after dental implant placement with flap and flapless surgical technique. Experimental study in pigs
VL  - 26
IS  - 11
SP  - 1309
EP  - 1314
DO  - 10.1111/clr.12456
ER  - 

@article{
author = "Vlahović, Zoran and Marković, Aleksa and Golubović, Mileta and Šćepanović, Miodrag and Kalanović, Milena and Đinić, Ana",
year = "2015",
abstract = "AimThe aim of this study was comparing the effect of flapless vs. flap technique of implant placement on inflammation degree of peri-implant soft tissue, through histopathological analysis. MethodThe experiment was conducted on five domestic pigs. Nine weeks after tooth extraction, implants were installed. Each animal received six implants in mandible. According to split-mouth design, randomly one side was used for flapless technique using mini-incision, while on the other side, flap was raised. After 7, 14, 21, 28, and 90days, the experimental animals were sacrificed. Samples for histopathological analyzes were taken from the buccal side of peri-implant mucosa next to the neck of implants, from three levels. The degree of inflammatory response in the peri-implant soft tissue was estimated through ordinal scores from 0 to 3. ResultsIn the flap group Score 3 indicating high degree of inflammation was present from day 7 to day 21, in contrast to flapless group where Score 3 was not recorded during the entire follow-up. Three months after implantation, there were no signs of inflammation neither around flap nor around flapless implants. ConclusionFlapless surgical implantation technique using mini-incision decreases peri-implant soft tissue inflammatory reaction compared with flap surgery.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Histopathological comparative analysis of peri-implant soft tissue response after dental implant placement with flap and flapless surgical technique. Experimental study in pigs",
volume = "26",
number = "11",
pages = "1309-1314",
doi = "10.1111/clr.12456"
}

Vlahović, Z., Marković, A., Golubović, M., Šćepanović, M., Kalanović, M.,& Đinić, A.. (2015). Histopathological comparative analysis of peri-implant soft tissue response after dental implant placement with flap and flapless surgical technique. Experimental study in pigs. in Clinical Oral Implants Research
Wiley, Hoboken., 26(11), 1309-1314.
https://doi.org/10.1111/clr.12456

Vlahović Z, Marković A, Golubović M, Šćepanović M, Kalanović M, Đinić A. Histopathological comparative analysis of peri-implant soft tissue response after dental implant placement with flap and flapless surgical technique. Experimental study in pigs. in Clinical Oral Implants Research. 2015;26(11):1309-1314.
doi:10.1111/clr.12456 .

Vlahović, Zoran, Marković, Aleksa, Golubović, Mileta, Šćepanović, Miodrag, Kalanović, Milena, Đinić, Ana, "Histopathological comparative analysis of peri-implant soft tissue response after dental implant placement with flap and flapless surgical technique. Experimental study in pigs" in Clinical Oral Implants Research, 26, no. 11 (2015):1309-1314,
https://doi.org/10.1111/clr.12456 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Čolić, Snježana
AU  - Šćepanović, Miodrag
AU  - Mišić, Tijana
AU  - Đinić, Ana
AU  - Bhusal, Dinesh Sharma
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2014
AB  - PurposesThe primary aim of the study was to investigate a 1-year success rate of early-loaded bone level implants with a chemically modified sand-blasted, large grit, acid-etched surface (SLActive (R), Institut Straumann AG, Basel, Switzerland) in the posterior maxilla. Secondary objectives included stability of these implants and peri-implant bone level. Materials and MethodsBone level (R) implants (Institut Straumann AG) inserted into premolar and/or molar maxillary sites were loaded after 6 weeks of healing. The implants were monitored for 1 year using the following outcome measures: implant success, primary and secondary stability, and peri-implant bone level. ResultsOut of 37 implants placed in 13 patients, 36 reached sufficient stability and were early loaded, whereas one underwent a delayed loading protocol. One-year success rate of early-loaded implants was 100%. Implant stability at baseline was 71.75. 6 to be steadily increased thereafter up to 1 year (80.3 +/- 3.3), except at 2 weeks when a nonsignificant decrease was noticed (71.9 +/- 3.9). Continuous and significant bone loss was observed, reaching 0.4 +/- 0.1mm in the first postoperative year. ConclusionBone level implants with the SLActive surface placed into low-density bone and loaded after 6 weeks of healing can predictably achieve and maintain a successful tissue integration.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - A 1-Year Prospective Clinical and Radiographic Study of Early-Loaded Bone Level Implants in the Posterior Maxilla
VL  - 17
IS  - 5
SP  - 1004
EP  - 1013
DO  - 10.1111/cid.12201
ER  - 

@article{
author = "Marković, Aleksa and Čolić, Snježana and Šćepanović, Miodrag and Mišić, Tijana and Đinić, Ana and Bhusal, Dinesh Sharma",
year = "2015",
abstract = "PurposesThe primary aim of the study was to investigate a 1-year success rate of early-loaded bone level implants with a chemically modified sand-blasted, large grit, acid-etched surface (SLActive (R), Institut Straumann AG, Basel, Switzerland) in the posterior maxilla. Secondary objectives included stability of these implants and peri-implant bone level. Materials and MethodsBone level (R) implants (Institut Straumann AG) inserted into premolar and/or molar maxillary sites were loaded after 6 weeks of healing. The implants were monitored for 1 year using the following outcome measures: implant success, primary and secondary stability, and peri-implant bone level. ResultsOut of 37 implants placed in 13 patients, 36 reached sufficient stability and were early loaded, whereas one underwent a delayed loading protocol. One-year success rate of early-loaded implants was 100%. Implant stability at baseline was 71.75. 6 to be steadily increased thereafter up to 1 year (80.3 +/- 3.3), except at 2 weeks when a nonsignificant decrease was noticed (71.9 +/- 3.9). Continuous and significant bone loss was observed, reaching 0.4 +/- 0.1mm in the first postoperative year. ConclusionBone level implants with the SLActive surface placed into low-density bone and loaded after 6 weeks of healing can predictably achieve and maintain a successful tissue integration.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "A 1-Year Prospective Clinical and Radiographic Study of Early-Loaded Bone Level Implants in the Posterior Maxilla",
volume = "17",
number = "5",
pages = "1004-1013",
doi = "10.1111/cid.12201"
}

Marković, A., Čolić, S., Šćepanović, M., Mišić, T., Đinić, A.,& Bhusal, D. S.. (2015). A 1-Year Prospective Clinical and Radiographic Study of Early-Loaded Bone Level Implants in the Posterior Maxilla. in Clinical Implant Dentistry & Related Research
Wiley-Blackwell, Hoboken., 17(5), 1004-1013.
https://doi.org/10.1111/cid.12201

Marković A, Čolić S, Šćepanović M, Mišić T, Đinić A, Bhusal DS. A 1-Year Prospective Clinical and Radiographic Study of Early-Loaded Bone Level Implants in the Posterior Maxilla. in Clinical Implant Dentistry & Related Research. 2015;17(5):1004-1013.
doi:10.1111/cid.12201 .

Marković, Aleksa, Čolić, Snježana, Šćepanović, Miodrag, Mišić, Tijana, Đinić, Ana, Bhusal, Dinesh Sharma, "A 1-Year Prospective Clinical and Radiographic Study of Early-Loaded Bone Level Implants in the Posterior Maxilla" in Clinical Implant Dentistry & Related Research, 17, no. 5 (2015):1004-1013,
https://doi.org/10.1111/cid.12201 . .

TY  - JOUR
AU  - Šćepanović, Miodrag
AU  - Todorović, Aleksandar
AU  - Marković, Aleksa
AU  - Patrnogić, Vesna
AU  - Miličić, Biljana
AU  - Moufti, Adel M.
AU  - Mišić, Tijana
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2048
AB  - Aim: This 1-year cohort study investigated stability and pen-implant marginal bone level of immediately loaded mini dental implants used to retain overdentures. Materials and methods: Each of 30 edentulous patients received 4 mini dental implants (1.8 mm x 13 mm) in the interforaminal mandibular region. The implants were immediately loaded with pre-made overdentures. Outcome measures included implant stability and bone resorption. Implant stability was measured using the Periotest Classic (R) device immediately after placement and on the 3rd and 6th weeks and the 4th, 6th and 12th months postoperatively. The pen-implant marginal bone level (PIBL) was evaluated at the implant's mesial and distal sides from the polished platform to the marginal crest. Radiographs were taken using a tailored film holder to reproducibly position the X-ray tube at the 6th week, 4th and 12th months postoperatively. Results: The primary stability (Periotest value, PTV) measured -0.27 +/- 3.41 on a scale of -8 to + 50 (lower PTV reflects higher stability). The secondary stability decreased significantly until week 6 (mean PTV = 7.61 +/- 7.05) then increased significantly reaching (PTV = 6.17 +/- 6.15) at 12 months. The mean PIBL measured 0.40 mm after 1 year of functional loading, with no statistically significant differences at the various follow-ups (p = 0.218). Conclusions: Mini dental implants placed into the interforaminal region could achieve a favorable primary stability for immediate loading. The follow-up Periotest values fluctuated, apparently reflecting the dynamics of bone remodeling, with the implants remaining clinically stable (98.3%) after 1 year of function. The 1-year bone resorption around immediately loaded MDIs is within the clinically acceptable range for standard implants.
PB  - Elsevier Gmbh, Urban & Fischer Verlag, Jena
T2  - Annals of Anatomy - Anatomischer Anzeiger
T1  - Immediately loaded mini dental implants as overdenture retainers: 1-Year cohort study of implant stability and peri-implant marginal bone level
VL  - 199
SP  - 85
EP  - 91
DO  - 10.1016/j.aanat.2013.12.005
ER  - 

@article{
author = "Šćepanović, Miodrag and Todorović, Aleksandar and Marković, Aleksa and Patrnogić, Vesna and Miličić, Biljana and Moufti, Adel M. and Mišić, Tijana",
year = "2015",
abstract = "Aim: This 1-year cohort study investigated stability and pen-implant marginal bone level of immediately loaded mini dental implants used to retain overdentures. Materials and methods: Each of 30 edentulous patients received 4 mini dental implants (1.8 mm x 13 mm) in the interforaminal mandibular region. The implants were immediately loaded with pre-made overdentures. Outcome measures included implant stability and bone resorption. Implant stability was measured using the Periotest Classic (R) device immediately after placement and on the 3rd and 6th weeks and the 4th, 6th and 12th months postoperatively. The pen-implant marginal bone level (PIBL) was evaluated at the implant's mesial and distal sides from the polished platform to the marginal crest. Radiographs were taken using a tailored film holder to reproducibly position the X-ray tube at the 6th week, 4th and 12th months postoperatively. Results: The primary stability (Periotest value, PTV) measured -0.27 +/- 3.41 on a scale of -8 to + 50 (lower PTV reflects higher stability). The secondary stability decreased significantly until week 6 (mean PTV = 7.61 +/- 7.05) then increased significantly reaching (PTV = 6.17 +/- 6.15) at 12 months. The mean PIBL measured 0.40 mm after 1 year of functional loading, with no statistically significant differences at the various follow-ups (p = 0.218). Conclusions: Mini dental implants placed into the interforaminal region could achieve a favorable primary stability for immediate loading. The follow-up Periotest values fluctuated, apparently reflecting the dynamics of bone remodeling, with the implants remaining clinically stable (98.3%) after 1 year of function. The 1-year bone resorption around immediately loaded MDIs is within the clinically acceptable range for standard implants.",
publisher = "Elsevier Gmbh, Urban & Fischer Verlag, Jena",
journal = "Annals of Anatomy - Anatomischer Anzeiger",
title = "Immediately loaded mini dental implants as overdenture retainers: 1-Year cohort study of implant stability and peri-implant marginal bone level",
volume = "199",
pages = "85-91",
doi = "10.1016/j.aanat.2013.12.005"
}

Šćepanović, M., Todorović, A., Marković, A., Patrnogić, V., Miličić, B., Moufti, A. M.,& Mišić, T.. (2015). Immediately loaded mini dental implants as overdenture retainers: 1-Year cohort study of implant stability and peri-implant marginal bone level. in Annals of Anatomy - Anatomischer Anzeiger
Elsevier Gmbh, Urban & Fischer Verlag, Jena., 199, 85-91.
https://doi.org/10.1016/j.aanat.2013.12.005

Šćepanović M, Todorović A, Marković A, Patrnogić V, Miličić B, Moufti AM, Mišić T. Immediately loaded mini dental implants as overdenture retainers: 1-Year cohort study of implant stability and peri-implant marginal bone level. in Annals of Anatomy - Anatomischer Anzeiger. 2015;199:85-91.
doi:10.1016/j.aanat.2013.12.005 .

Šćepanović, Miodrag, Todorović, Aleksandar, Marković, Aleksa, Patrnogić, Vesna, Miličić, Biljana, Moufti, Adel M., Mišić, Tijana, "Immediately loaded mini dental implants as overdenture retainers: 1-Year cohort study of implant stability and peri-implant marginal bone level" in Annals of Anatomy - Anatomischer Anzeiger, 199 (2015):85-91,
https://doi.org/10.1016/j.aanat.2013.12.005 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Calvo Guirado, Jose Luis
AU  - Abboud, Marcus
AU  - Piedad Ramirez-Fernandez, Maria
AU  - Eduardo Mate-Sanchez, Jose
AU  - Negri, Bruno
AU  - Gomez-Moreno, Gerardo
AU  - Marković, Aleksa
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1970
AB  - PurposeTo describe contact, thickness, density, and orientation of connective tissue fibers around healing abutments of different geometries by means of a new method using coordinates. Materials and MethodsFollowing the bilateral extraction of mandibular premolars (P2, P3, and P4) from six fox hound dogs and a 2-month healing period, 36 titanium implants were inserted, onto which two groups of healing abutments of different geometry were screwed: Group A (concave abutments) and Group B (wider healing abutment). After 3 months the animals were sacrificed and samples extracted containing each implant and surrounding soft and hard tissues. Histological analysis was performed without decalcifying the samples by means of circularly polarized light under optical microscope and a system of vertical and horizontal coordinates across all the connective tissue in an area delimited by the implant/abutment, epithelium, and bone tissue. ResultsIn no case had the connective tissue formed a connection to the healing abutment/implant in the internal zone; a space of 3510m separated the connective tissue fibers from the healing abutment surface. The total thickness of connective tissue in the horizontal direction was significantly greater in the medial zone in Group B than in Group A (p lt .05). The orientation of the fibers varied according to the coordinate area so that internal coordinates showed a higher percentage of parallel fibers in Group A (p lt .05) and a higher percentage of oblique fibers in Group B (p lt .05); medial coordinates showed more oblique fibers (p lt .05); and the area of external coordinates showed the highest percentage of perpendicular fibers (p lt .05). The fiber density was higher in the basal and medial areas (p lt .05). ConclusionsAbutment geometry influences the orientation of collagen fibers; therefore, an abutment with a profile wider than the implant platform favors oblique and perpendicular orientation of collagen fibers and greater connective tissue thickness.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light
VL  - 17
IS  - 4
SP  - 667
EP  - 680
DO  - 10.1111/cid.12161
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Calvo Guirado, Jose Luis and Abboud, Marcus and Piedad Ramirez-Fernandez, Maria and Eduardo Mate-Sanchez, Jose and Negri, Bruno and Gomez-Moreno, Gerardo and Marković, Aleksa",
year = "2015",
abstract = "PurposeTo describe contact, thickness, density, and orientation of connective tissue fibers around healing abutments of different geometries by means of a new method using coordinates. Materials and MethodsFollowing the bilateral extraction of mandibular premolars (P2, P3, and P4) from six fox hound dogs and a 2-month healing period, 36 titanium implants were inserted, onto which two groups of healing abutments of different geometry were screwed: Group A (concave abutments) and Group B (wider healing abutment). After 3 months the animals were sacrificed and samples extracted containing each implant and surrounding soft and hard tissues. Histological analysis was performed without decalcifying the samples by means of circularly polarized light under optical microscope and a system of vertical and horizontal coordinates across all the connective tissue in an area delimited by the implant/abutment, epithelium, and bone tissue. ResultsIn no case had the connective tissue formed a connection to the healing abutment/implant in the internal zone; a space of 3510m separated the connective tissue fibers from the healing abutment surface. The total thickness of connective tissue in the horizontal direction was significantly greater in the medial zone in Group B than in Group A (p lt .05). The orientation of the fibers varied according to the coordinate area so that internal coordinates showed a higher percentage of parallel fibers in Group A (p lt .05) and a higher percentage of oblique fibers in Group B (p lt .05); medial coordinates showed more oblique fibers (p lt .05); and the area of external coordinates showed the highest percentage of perpendicular fibers (p lt .05). The fiber density was higher in the basal and medial areas (p lt .05). ConclusionsAbutment geometry influences the orientation of collagen fibers; therefore, an abutment with a profile wider than the implant platform favors oblique and perpendicular orientation of collagen fibers and greater connective tissue thickness.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light",
volume = "17",
number = "4",
pages = "667-680",
doi = "10.1111/cid.12161"
}

Delgado-Ruiz, R., Calvo Guirado, J. L., Abboud, M., Piedad Ramirez-Fernandez, M., Eduardo Mate-Sanchez, J., Negri, B., Gomez-Moreno, G.,& Marković, A.. (2015). Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 17(4), 667-680.
https://doi.org/10.1111/cid.12161

Delgado-Ruiz R, Calvo Guirado JL, Abboud M, Piedad Ramirez-Fernandez M, Eduardo Mate-Sanchez J, Negri B, Gomez-Moreno G, Marković A. Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light. in Clinical Implant Dentistry & Related Research. 2015;17(4):667-680.
doi:10.1111/cid.12161 .

Delgado-Ruiz, Rafael, Calvo Guirado, Jose Luis, Abboud, Marcus, Piedad Ramirez-Fernandez, Maria, Eduardo Mate-Sanchez, Jose, Negri, Bruno, Gomez-Moreno, Gerardo, Marković, Aleksa, "Connective Tissue Characteristics around Healing Abutments of Different Geometries: New Methodological Technique under Circularly Polarized Light" in Clinical Implant Dentistry & Related Research, 17, no. 4 (2015):667-680,
https://doi.org/10.1111/cid.12161 . .

TY  - JOUR
AU  - Lazić, Zoran
AU  - Golubović, Mileta
AU  - Marković, Aleksa
AU  - Šćepanović, Miodrag
AU  - Mišić, Tijana
AU  - Vlahović, Zoran
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1964
AB  - AimThe aim of this experimental study is to compare the effect of mini-incision flapless versus flap technique of implant placement on the amount of vascular structures and blood vessel elements in peri-implant soft tissue, using immunohistochemical analysis. MethodThe experiment was conducted on five domestic pigs. Each animal received six implants in mandible according to the split-mouth design. On one randomly chosen jaw side, mini-incision flapless surgery was performed, whereas on the opposite jaw side, flap was raised. After 3months of implant healing through submerged approach, the experimental animals were sacrificed and samples for immunohistochemical analyses were taken from the buccal side of peri-implant mucosa next to the neck of implants, from three levels. The study outcome was the presence of vascular structures and elements of the blood vessels in the peri-implant mucosa per microscopic field, estimated through ordinal scores from 0 to 2. Effects of surgical approach, site of implantation, and their interaction on vascular scores of peri-implant mucosa were assessed by Brunner and Langer nonparametric analysis of longitudinal data. ResultsStatistically significant effect of surgical approach on vascularity of peri-implant mucosa has been revealed in the second mucosal layer, where flapless approach provided higher vascularity compared with flap approach (P=0.002). In the remaining two layers, surgical approach did not affect mucosal vascularity significantly (layer 1: P=0.071; layer 3: P=0.433). ConclusionThe flapless surgical implant placement approach using mini-incision provides better vascularization of peri-implant mucosa after 3months of healing compared with flap surgery.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Oral Implants Research
T1  - Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs
VL  - 26
IS  - 7
SP  - 775
EP  - 779
DO  - 10.1111/clr.12337
ER  - 

@article{
author = "Lazić, Zoran and Golubović, Mileta and Marković, Aleksa and Šćepanović, Miodrag and Mišić, Tijana and Vlahović, Zoran",
year = "2015",
abstract = "AimThe aim of this experimental study is to compare the effect of mini-incision flapless versus flap technique of implant placement on the amount of vascular structures and blood vessel elements in peri-implant soft tissue, using immunohistochemical analysis. MethodThe experiment was conducted on five domestic pigs. Each animal received six implants in mandible according to the split-mouth design. On one randomly chosen jaw side, mini-incision flapless surgery was performed, whereas on the opposite jaw side, flap was raised. After 3months of implant healing through submerged approach, the experimental animals were sacrificed and samples for immunohistochemical analyses were taken from the buccal side of peri-implant mucosa next to the neck of implants, from three levels. The study outcome was the presence of vascular structures and elements of the blood vessels in the peri-implant mucosa per microscopic field, estimated through ordinal scores from 0 to 2. Effects of surgical approach, site of implantation, and their interaction on vascular scores of peri-implant mucosa were assessed by Brunner and Langer nonparametric analysis of longitudinal data. ResultsStatistically significant effect of surgical approach on vascularity of peri-implant mucosa has been revealed in the second mucosal layer, where flapless approach provided higher vascularity compared with flap approach (P=0.002). In the remaining two layers, surgical approach did not affect mucosal vascularity significantly (layer 1: P=0.071; layer 3: P=0.433). ConclusionThe flapless surgical implant placement approach using mini-incision provides better vascularization of peri-implant mucosa after 3months of healing compared with flap surgery.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs",
volume = "26",
number = "7",
pages = "775-779",
doi = "10.1111/clr.12337"
}

Lazić, Z., Golubović, M., Marković, A., Šćepanović, M., Mišić, T.,& Vlahović, Z.. (2015). Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs. in Clinical Oral Implants Research
Wiley-Blackwell, Hoboken., 26(7), 775-779.
https://doi.org/10.1111/clr.12337

Lazić Z, Golubović M, Marković A, Šćepanović M, Mišić T, Vlahović Z. Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs. in Clinical Oral Implants Research. 2015;26(7):775-779.
doi:10.1111/clr.12337 .

Lazić, Zoran, Golubović, Mileta, Marković, Aleksa, Šćepanović, Miodrag, Mišić, Tijana, Vlahović, Zoran, "Immunohistochemical analysis of blood vessels in peri-implant mucosa: a comparison between mini-incision flapless and flap surgeries in domestic pigs" in Clinical Oral Implants Research, 26, no. 7 (2015):775-779,
https://doi.org/10.1111/clr.12337 . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Mancić, Dragan
AU  - Jovanović, Igor
AU  - Šćepanović, Miodrag
AU  - Jezdić, Zoran
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1877
AB  - Objectives: To compare the effect of two surgical techniques, lateral condensation and bone drilling, on changes in temperature of the adjacent low-density bone during implant placement into posterior maxilla and to investigate the influence of the host factors - age, gender, region of implantation, bone density, and thickness of the cortical bone at the recipient sites. Material and methods: Local bone temperature was measured thermographically during implant placement into posterior maxilla following lateral bone condensing (test group) or bone drilling (controls). The main study outcomes were baseline bone temperature prior to implantation and maximum bone temperature recorded during implantation. Early implant success was evaluated after 6 months of healing. Results: A total of 40 implants were randomly allocated to test and control groups and placed into maxillary premolar and/or molar region of 18 participants of both genders and average age of 51.74 years. All recorded bone temperatures were below the threshold for thermal necrosis. Although both groups showed significant increase in bone temperature during implant placement procedure (P  lt = 0.0005), it was significantly higher for bone condensing compared with drilling (P  lt = 0.0005; 3.79 +/- 1.54 degrees C; 1.91 +/- 0.70 degrees C respectively). No host factor was singled out as a significant predictor of bone temperature changes, although trend of higher increase was observed in young patients, regardless of gender, during implant placement procedure into maxillary first premolar region with bone density type 3 and cortical layer thicker than 1 mm. Early implant success rate after 6 months follow-up was 100%. Conclusion: Although both surgical techniques, bone condensing and bone drilling, can be considered safe regarding their thermal effect on the bone of posterior maxilla, bone drilling is associated with fewer local bone heating during implantation. Host factors do not affect the bone thermal changes significantly.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique
VL  - 25
IS  - 8
SP  - 910
EP  - 918
DO  - 10.1111/clr.12191
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Mancić, Dragan and Jovanović, Igor and Šćepanović, Miodrag and Jezdić, Zoran",
year = "2014",
abstract = "Objectives: To compare the effect of two surgical techniques, lateral condensation and bone drilling, on changes in temperature of the adjacent low-density bone during implant placement into posterior maxilla and to investigate the influence of the host factors - age, gender, region of implantation, bone density, and thickness of the cortical bone at the recipient sites. Material and methods: Local bone temperature was measured thermographically during implant placement into posterior maxilla following lateral bone condensing (test group) or bone drilling (controls). The main study outcomes were baseline bone temperature prior to implantation and maximum bone temperature recorded during implantation. Early implant success was evaluated after 6 months of healing. Results: A total of 40 implants were randomly allocated to test and control groups and placed into maxillary premolar and/or molar region of 18 participants of both genders and average age of 51.74 years. All recorded bone temperatures were below the threshold for thermal necrosis. Although both groups showed significant increase in bone temperature during implant placement procedure (P  lt = 0.0005), it was significantly higher for bone condensing compared with drilling (P  lt = 0.0005; 3.79 +/- 1.54 degrees C; 1.91 +/- 0.70 degrees C respectively). No host factor was singled out as a significant predictor of bone temperature changes, although trend of higher increase was observed in young patients, regardless of gender, during implant placement procedure into maxillary first premolar region with bone density type 3 and cortical layer thicker than 1 mm. Early implant success rate after 6 months follow-up was 100%. Conclusion: Although both surgical techniques, bone condensing and bone drilling, can be considered safe regarding their thermal effect on the bone of posterior maxilla, bone drilling is associated with fewer local bone heating during implantation. Host factors do not affect the bone thermal changes significantly.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique",
volume = "25",
number = "8",
pages = "910-918",
doi = "10.1111/clr.12191"
}

Marković, A., Mišić, T., Mancić, D., Jovanović, I., Šćepanović, M.,& Jezdić, Z.. (2014). Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique. in Clinical Oral Implants Research
Wiley, Hoboken., 25(8), 910-918.
https://doi.org/10.1111/clr.12191

Marković A, Mišić T, Mancić D, Jovanović I, Šćepanović M, Jezdić Z. Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique. in Clinical Oral Implants Research. 2014;25(8):910-918.
doi:10.1111/clr.12191 .

Marković, Aleksa, Mišić, Tijana, Mancić, Dragan, Jovanović, Igor, Šćepanović, Miodrag, Jezdić, Zoran, "Real-time thermographic analysis of low-density bone during implant placement: a randomized parallel-group clinical study comparing lateral condensation with bone drilling surgical technique" in Clinical Oral Implants Research, 25, no. 8 (2014):910-918,
https://doi.org/10.1111/clr.12191 . .

TY  - JOUR
AU  - Delgado-Ruiz, Rafael
AU  - Marković, Aleksa
AU  - Calvo Guirado, Jose Luis
AU  - Lazić, Zoran
AU  - Piattelli, Adriano
AU  - Boticelli, Daniele
AU  - Maté-Sánchez, José Eduardo
AU  - Negri, Bruno
AU  - Ramírez-Fernández, María Piedad
AU  - Mišić, Tijana
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1900
AB  - Background/Aim. The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched titanium implants. Methods. Implant surface characterization was performed using optical interferometric profilometry and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound dogs divided into groups of 24 each: the control (titanium), the group A (sandblasted zirconia), the group B (sandblasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative scanning electon microscope (SEM) analysis of the bone-implant interfaces of each group was performed. Results. Insertion torque values were higher in the group C and control implants (p  lt  0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p  lt  0.05). Radiographic measurements showed minimal crestal bone loss at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p  lt  0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p  lt  0.05). SEM showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. Conclusion. The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue in growth and preserves crestal bone levels.
AB  - Uvod/Cilj. Modifikacija površine implantata može uticati na njegovu mehaničku stabilnost kao i na dinamiku i kvalitet periimplantatnog koštanog zarastanja. Cilj ove tromesečne eksperimentalne studije na psima bio je da se ispita stabilnost implantata, nivo marginalne kosti i odgovor koštanog tkiva na cirkonijum endoosealne implantate sa dve intraosealne površine mikrostrukturirane laserom u poređenju sa peskiranim cirkonijum implantatima čija površina nije mikrostrukturirana kao i sa titanijum implantatima čije su površine peskirane i nagrižene visokom temperaturom. Metode. Karakterizacija površine implantata učinjena je optičkom interferometrijskom profilometrijom i analizom energetskog spektra pri difrakciji X-zračenja. Ukupno 96 implantata (prečnika 4 mm i dužine 10 mm) ugrađeno je nasumično i obostrano u donju vilicu kod 12 pasa (lisičara) i podeljeno u četiri grupe po 24: kontrolna (titanijum implantati); grupa A (peskirani cirkonijum implantati); grupa B (peskirani cirkonijum implantati sa mikrokanalima u koronarnoj trećini); grupa C (peskirani cirkonijum implantati sa mikrokanalima duž cele površine). Svi implantati su odmah opterećeni. Meren je obrtni momenat pri ugradnji implantata, vrednosti periotesta, radiografski nivo marginalne kosti i obrtni moment za uklanjanje implantata tokom tromesečnog perioda praćenja. Međuspoj kosti i implantata iz svake grupe ispitivan je kvalitativnom skenirajućom elektronskom mikroskopijom (SEM). Rezultati. Veći obrtni momenat zabeležen je pri ugradnji implantata kod grupe C i kontrolne grupe (p  lt  0,05). U ispitivanom vremenskom periodu, vrednosti periotesta uvećavale su se srazmerno obimu mikrostrukturiranja površine i to: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Radiografskom analizom utvrđen je minimalni gubitak marginalne kosti u trećem mesecu praćenja oko cirkonijum implantata sa mikrokanalima (grupa B i C) i kontrola u poređenju sa implantatima grupe A (p  lt  0,05). Vrednosti obrtnog momenta za uklanjanje implantata vremenom su se uvećavale u svim grupama na sledeći način: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Kod implantatnih površina grupa B i C, SEM je pokazala dodatni rast koštanog tkiva unutar mikrokanala koji odgovara njihovom obliku i pravcu. Zaključak. Formiranje mikrokanala duž cele intraosealne površine cirkonijum endoosealnih implantata povećava primarnu i sekundarnu implantatnu stabilnost, podstiče urastanje koštanog tkiva i održava nivo marginalne kosti.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs
T1  - Implantatna stabilnost i nivo marginalne kosti kod cirkonijum endoosealnih implantata sa mikrostrukturiranom površinom - tromesečna eksperimentalna studija na psima
VL  - 71
IS  - 5
SP  - 451
EP  - 461
DO  - 10.2298/VSP121003034D
ER  - 

@article{
author = "Delgado-Ruiz, Rafael and Marković, Aleksa and Calvo Guirado, Jose Luis and Lazić, Zoran and Piattelli, Adriano and Boticelli, Daniele and Maté-Sánchez, José Eduardo and Negri, Bruno and Ramírez-Fernández, María Piedad and Mišić, Tijana",
year = "2014",
abstract = "Background/Aim. The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants with two laser-micro-grooved intraosseous surfaces in comparison with nongrooved sandblasted zirconia and sandblasted, high-temperature etched titanium implants. Methods. Implant surface characterization was performed using optical interferometric profilometry and energy dispersive X-ray spectroscopy. A total of 96 implants (4 mm in diameter and 10 mm in length) were inserted randomly in both sides of the lower jaw of 12 Fox Hound dogs divided into groups of 24 each: the control (titanium), the group A (sandblasted zirconia), the group B (sandblasted zirconia plus microgrooved neck) and the group C (sandblasted zirconia plus all microgrooved). All the implants were immediately loaded. Insertion torque, periotest values, radiographic crestal bone level and removal torque were recorded during the 3-month follow-up. Qualitative scanning electon microscope (SEM) analysis of the bone-implant interfaces of each group was performed. Results. Insertion torque values were higher in the group C and control implants (p  lt  0.05). Periotest values increased in all the periods in proportion to the extent of microgrooving as follows: the group C > the control > the group B > the group A (p  lt  0.05). Radiographic measurements showed minimal crestal bone loss at 3 months for microgrooved zirconia implants (groups C and B) and control implants compared with the group A implants (p  lt  0.05). The removal torque values increased with time for all the groups as follows: the group C > the control > the group B > the group A (p  lt  0.05). SEM showed that implant surfaces of the groups B and C had an extra bone growth inside the microgrooves that corresponded to the shape and direction of the microgrooves. Conclusion. The addition of microgrooves to the entire intraosseous surface of zirconia dental implants enhances primary and secondary implant stability, promotes bone tissue in growth and preserves crestal bone levels., Uvod/Cilj. Modifikacija površine implantata može uticati na njegovu mehaničku stabilnost kao i na dinamiku i kvalitet periimplantatnog koštanog zarastanja. Cilj ove tromesečne eksperimentalne studije na psima bio je da se ispita stabilnost implantata, nivo marginalne kosti i odgovor koštanog tkiva na cirkonijum endoosealne implantate sa dve intraosealne površine mikrostrukturirane laserom u poređenju sa peskiranim cirkonijum implantatima čija površina nije mikrostrukturirana kao i sa titanijum implantatima čije su površine peskirane i nagrižene visokom temperaturom. Metode. Karakterizacija površine implantata učinjena je optičkom interferometrijskom profilometrijom i analizom energetskog spektra pri difrakciji X-zračenja. Ukupno 96 implantata (prečnika 4 mm i dužine 10 mm) ugrađeno je nasumično i obostrano u donju vilicu kod 12 pasa (lisičara) i podeljeno u četiri grupe po 24: kontrolna (titanijum implantati); grupa A (peskirani cirkonijum implantati); grupa B (peskirani cirkonijum implantati sa mikrokanalima u koronarnoj trećini); grupa C (peskirani cirkonijum implantati sa mikrokanalima duž cele površine). Svi implantati su odmah opterećeni. Meren je obrtni momenat pri ugradnji implantata, vrednosti periotesta, radiografski nivo marginalne kosti i obrtni moment za uklanjanje implantata tokom tromesečnog perioda praćenja. Međuspoj kosti i implantata iz svake grupe ispitivan je kvalitativnom skenirajućom elektronskom mikroskopijom (SEM). Rezultati. Veći obrtni momenat zabeležen je pri ugradnji implantata kod grupe C i kontrolne grupe (p  lt  0,05). U ispitivanom vremenskom periodu, vrednosti periotesta uvećavale su se srazmerno obimu mikrostrukturiranja površine i to: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Radiografskom analizom utvrđen je minimalni gubitak marginalne kosti u trećem mesecu praćenja oko cirkonijum implantata sa mikrokanalima (grupa B i C) i kontrola u poređenju sa implantatima grupe A (p  lt  0,05). Vrednosti obrtnog momenta za uklanjanje implantata vremenom su se uvećavale u svim grupama na sledeći način: grupa C > kontrolna grupa > grupa B > grupa A (p  lt  0,05). Kod implantatnih površina grupa B i C, SEM je pokazala dodatni rast koštanog tkiva unutar mikrokanala koji odgovara njihovom obliku i pravcu. Zaključak. Formiranje mikrokanala duž cele intraosealne površine cirkonijum endoosealnih implantata povećava primarnu i sekundarnu implantatnu stabilnost, podstiče urastanje koštanog tkiva i održava nivo marginalne kosti.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs, Implantatna stabilnost i nivo marginalne kosti kod cirkonijum endoosealnih implantata sa mikrostrukturiranom površinom - tromesečna eksperimentalna studija na psima",
volume = "71",
number = "5",
pages = "451-461",
doi = "10.2298/VSP121003034D"
}

Delgado-Ruiz, R., Marković, A., Calvo Guirado, J. L., Lazić, Z., Piattelli, A., Boticelli, D., Maté-Sánchez, J. E., Negri, B., Ramírez-Fernández, M. P.,& Mišić, T.. (2014). Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(5), 451-461.
https://doi.org/10.2298/VSP121003034D

Delgado-Ruiz R, Marković A, Calvo Guirado JL, Lazić Z, Piattelli A, Boticelli D, Maté-Sánchez JE, Negri B, Ramírez-Fernández MP, Mišić T. Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs. in Vojnosanitetski pregled. 2014;71(5):451-461.
doi:10.2298/VSP121003034D .

Delgado-Ruiz, Rafael, Marković, Aleksa, Calvo Guirado, Jose Luis, Lazić, Zoran, Piattelli, Adriano, Boticelli, Daniele, Maté-Sánchez, José Eduardo, Negri, Bruno, Ramírez-Fernández, María Piedad, Mišić, Tijana, "Implant stability and marginal bone level of microgrooved zirconia dental implants: A 3-month experimental study on dogs" in Vojnosanitetski pregled, 71, no. 5 (2014):451-461,
https://doi.org/10.2298/VSP121003034D . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Mišić, Tijana
AU  - Miličić, Biljana
AU  - Calvo Guirado, Jose Luis
AU  - Aleksić, Zoran
AU  - Đinić, Ana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1830
AB  - Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during implant placement. Material and methods In the in vitro study, 144 self-tapping (blueSKY (R) 4x10mm; Bredent) and 144 non-self-tapping (Standard implant (R) 4.1x10mm; Straumann) were placed in osteotomies prepared in pig ribs by lateral bone condensing or bone drilling techniques. The maximum insertion torque values of 30, 35 and 40Ncm were used. Real-time bone temperature measurement during implant placement was performed by three thermocouples positioned vertically, in tripod configuration around every osteotomy, at a distance of 5mm from it and at depths of 1, 5 and 10mm. Data were analysed using Kruskal-Wallis, Mann-Whitney U-tests and Regression analysis. Results Significant predictor of bone temperature at the osteotomy depth of 1mm was insertion torque (P=0.003) and at the depth of 10-mm implant macrodesign (P=0.029), while no significant predictor at depth of 5mm was identified (0.05). Higher insertion torque values as well as non-self-tapping implant macrodesign were related to higher temperatures. Implant placement in sites prepared by bone drilling induced significantly higher temperature increase (P=0.021) compared with bone condensing sites at the depth of 5mm, while no significant difference was recorded at other depths. Compared with 30Ncm, insertion torque values of 35 and 40Ncm produced significantly higher temperature increase (P=0.005; P=0.003, respectively) at the depth of 1mm. There was no significant difference in temperature change induced by 35 and 40Ncm, neither by implant macrodesign at all investigated depths (0.05). Conclusions Placement of self-tapping implants with low insertion torque into sites prepared by lateral bone condensing technique might be advantageous in terms of thermal effect on bone.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical Oral Implants Research
T1  - Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design
VL  - 24
IS  - 7
SP  - 798
EP  - 805
DO  - 10.1111/j.1600-0501.2012.02460.x
ER  - 

@article{
author = "Marković, Aleksa and Mišić, Tijana and Miličić, Biljana and Calvo Guirado, Jose Luis and Aleksić, Zoran and Đinić, Ana",
year = "2013",
abstract = "Objectives The study aimed to investigate the effect of surgical technique, implant macrodesign and insertion torque on bone temperature changes during implant placement. Material and methods In the in vitro study, 144 self-tapping (blueSKY (R) 4x10mm; Bredent) and 144 non-self-tapping (Standard implant (R) 4.1x10mm; Straumann) were placed in osteotomies prepared in pig ribs by lateral bone condensing or bone drilling techniques. The maximum insertion torque values of 30, 35 and 40Ncm were used. Real-time bone temperature measurement during implant placement was performed by three thermocouples positioned vertically, in tripod configuration around every osteotomy, at a distance of 5mm from it and at depths of 1, 5 and 10mm. Data were analysed using Kruskal-Wallis, Mann-Whitney U-tests and Regression analysis. Results Significant predictor of bone temperature at the osteotomy depth of 1mm was insertion torque (P=0.003) and at the depth of 10-mm implant macrodesign (P=0.029), while no significant predictor at depth of 5mm was identified (0.05). Higher insertion torque values as well as non-self-tapping implant macrodesign were related to higher temperatures. Implant placement in sites prepared by bone drilling induced significantly higher temperature increase (P=0.021) compared with bone condensing sites at the depth of 5mm, while no significant difference was recorded at other depths. Compared with 30Ncm, insertion torque values of 35 and 40Ncm produced significantly higher temperature increase (P=0.005; P=0.003, respectively) at the depth of 1mm. There was no significant difference in temperature change induced by 35 and 40Ncm, neither by implant macrodesign at all investigated depths (0.05). Conclusions Placement of self-tapping implants with low insertion torque into sites prepared by lateral bone condensing technique might be advantageous in terms of thermal effect on bone.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design",
volume = "24",
number = "7",
pages = "798-805",
doi = "10.1111/j.1600-0501.2012.02460.x"
}

Marković, A., Mišić, T., Miličić, B., Calvo Guirado, J. L., Aleksić, Z.,& Đinić, A.. (2013). Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design. in Clinical Oral Implants Research
Wiley-Blackwell, Hoboken., 24(7), 798-805.
https://doi.org/10.1111/j.1600-0501.2012.02460.x

Marković A, Mišić T, Miličić B, Calvo Guirado JL, Aleksić Z, Đinić A. Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design. in Clinical Oral Implants Research. 2013;24(7):798-805.
doi:10.1111/j.1600-0501.2012.02460.x .

Marković, Aleksa, Mišić, Tijana, Miličić, Biljana, Calvo Guirado, Jose Luis, Aleksić, Zoran, Đinić, Ana, "Heat generation during implant placement in low-density bone: effect of surgical technique, insertion torque and implant macro design" in Clinical Oral Implants Research, 24, no. 7 (2013):798-805,
https://doi.org/10.1111/j.1600-0501.2012.02460.x . .

TY  - JOUR
AU  - Marković, Aleksa
AU  - Luis Calvo-Guirado, Jose
AU  - Lazić, Zoran
AU  - Gomez-Moreno, Gerardo
AU  - Ćalasan, Dejan
AU  - Guardia, Javier
AU  - Čolić, Snježana
AU  - Aguilar-Salvatierra, Antonio
AU  - Gačić, Bojan
AU  - Delgado-Ruiz, Rafael
AU  - Janjić, Bojan
AU  - Mišić, Tijana
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1816
AB  - Purpose: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). Materials and Methods: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent (R) (Bredent GmbH &, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann (R) (Institut Straumann AG (R), Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. Results: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. Conclusions: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.
PB  - Wiley, Hoboken
T2  - Clinical Implant Dentistry & Related Research
T1  - Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study
VL  - 15
IS  - 3
SP  - 341
EP  - 349
DO  - 10.1111/j.1708-8208.2011.00415.x
ER  - 

@article{
author = "Marković, Aleksa and Luis Calvo-Guirado, Jose and Lazić, Zoran and Gomez-Moreno, Gerardo and Ćalasan, Dejan and Guardia, Javier and Čolić, Snježana and Aguilar-Salvatierra, Antonio and Gačić, Bojan and Delgado-Ruiz, Rafael and Janjić, Bojan and Mišić, Tijana",
year = "2013",
abstract = "Purpose: The aim of this study was to investigate the relationship between surgical techniques and implant macro-design (self-tapping/non-self-tapping) for the optimization of implant stability in the low-density bone present in the posterior maxilla using resonance frequency analysis (RFA). Materials and Methods: A total of 102 implants were studied. Fifty-six self-tapping BlueSkyBredent (R) (Bredent GmbH &, Senden, Germany) and 56 non-self-tapping Standard Plus Straumann (R) (Institut Straumann AG (R), Waldenburg, Switzerland) were placed in the posterior segment of the maxilla. Implants of both types were placed in sites prepared with either lateral bone-condensing or with bone-drilling techniques. Implant stability measurements were performed using RFA immediately after implant placement and weekly during a 12-week follow-up period. Results: Both types of implants placed after bone condensing achieved significantly higher stability immediately after surgery, as well as during the entire 12-week observation period compared with those placed following bone drilling. After bone condensation, there were no significant differences in primary stability or in implant stability after the first week between both implant types. From 2 to 12 postoperative weeks, significantly higher stability was shown by self-tapping implants. After bone drilling, self-tapping implants achieved significantly higher stability than non-self-tapping implants during the entire follow-up period. Conclusions: The outcomes of the present study indicate that bone drilling is not an effective technique for improving implant stability and, following this technique, the use of self-tapping implants is highly recommended. Implant stability optimization in the soft bone can be achieved by lateral bone-condensing technique, regardless of implant macro-design.",
publisher = "Wiley, Hoboken",
journal = "Clinical Implant Dentistry & Related Research",
title = "Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study",
volume = "15",
number = "3",
pages = "341-349",
doi = "10.1111/j.1708-8208.2011.00415.x"
}

Marković, A., Luis Calvo-Guirado, J., Lazić, Z., Gomez-Moreno, G., Ćalasan, D., Guardia, J., Čolić, S., Aguilar-Salvatierra, A., Gačić, B., Delgado-Ruiz, R., Janjić, B.,& Mišić, T.. (2013). Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study. in Clinical Implant Dentistry & Related Research
Wiley, Hoboken., 15(3), 341-349.
https://doi.org/10.1111/j.1708-8208.2011.00415.x

Marković A, Luis Calvo-Guirado J, Lazić Z, Gomez-Moreno G, Ćalasan D, Guardia J, Čolić S, Aguilar-Salvatierra A, Gačić B, Delgado-Ruiz R, Janjić B, Mišić T. Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study. in Clinical Implant Dentistry & Related Research. 2013;15(3):341-349.
doi:10.1111/j.1708-8208.2011.00415.x .

Marković, Aleksa, Luis Calvo-Guirado, Jose, Lazić, Zoran, Gomez-Moreno, Gerardo, Ćalasan, Dejan, Guardia, Javier, Čolić, Snježana, Aguilar-Salvatierra, Antonio, Gačić, Bojan, Delgado-Ruiz, Rafael, Janjić, Bojan, Mišić, Tijana, "Evaluation of Primary Stability of Self-Tapping and Non-Self-Tapping Dental Implants. A 12-Week Clinical Study" in Clinical Implant Dentistry & Related Research, 15, no. 3 (2013):341-349,
https://doi.org/10.1111/j.1708-8208.2011.00415.x . .

TY  - JOUR
AU  - Šćepanović, Miodrag
AU  - Luis Calvo-Guirado, Jose
AU  - Marković, Aleksa
AU  - Delgado-Ruiz, Rafael
AU  - Todorović, Aleksandar
AU  - Miličić, Biljana
AU  - Mišić, Tijana
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1687
AB  - Aim: The aim of this 1-year prospective cohort study was to evaluate the outcomes and complications of immediately loaded mini dental implants used for stabilizing mandibular overdentures in edentulous patients wearing conventional complete dentures. Materials and methods: Thirty patients received mandibular conventional complete dentures that were subsequently retained by 4 immediately loaded mini dental implants placed in the interforaminal region. Overdenture success, implant success and biological and prosthetic complications were evaluated after the first year of service. Quality of life using the Oral Heath Impact Profile (OHIP)-EDENT test, satisfaction with dental prosthesis and chewing efficiency using questionnaires and a Visual Analogue Scale (VAS) were evaluated twice: after they had received mandibular complete dentures, and again after they had received mandibular overdentures. Results: After 1 year, no overdenture failed and 2 implants did not osseointegrate, resulting in a 98.3% success rate for loaded implants and 95.9% for total implants used (3 out of 123 were not loaded due to fracture). A flap surgical approach was performed in 7 patients, 3 implants fractured during insertion, 3 overdentures fractured, occlusion balancing was necessary for 11 dentures and relining for 8. Implant rehabilitation provided significant improvement in quality of life, stability, comfort, chewing and speaking ability while no significant differences were found in quality of maintenance of hygiene and for aesthetics. Conclusions: Mini dental implant retained overdentures can be a successful therapeutic procedure for treating mandibular edentulism that improves quality of life, patient satisfaction and chewing ability in patients wearing maxillary dentures. Longer follow-ups are needed to validate this therapy in the medium and long-term.
PB  - Quintessence Publishing Co., Ltd
T2  - European Journal of Oral Implantology
T1  - A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants
VL  - 5
IS  - 4
SP  - 367
EP  - 379
UR  - https://hdl.handle.net/21.15107/rcub_smile_1687
ER  - 

@article{
author = "Šćepanović, Miodrag and Luis Calvo-Guirado, Jose and Marković, Aleksa and Delgado-Ruiz, Rafael and Todorović, Aleksandar and Miličić, Biljana and Mišić, Tijana",
year = "2012",
abstract = "Aim: The aim of this 1-year prospective cohort study was to evaluate the outcomes and complications of immediately loaded mini dental implants used for stabilizing mandibular overdentures in edentulous patients wearing conventional complete dentures. Materials and methods: Thirty patients received mandibular conventional complete dentures that were subsequently retained by 4 immediately loaded mini dental implants placed in the interforaminal region. Overdenture success, implant success and biological and prosthetic complications were evaluated after the first year of service. Quality of life using the Oral Heath Impact Profile (OHIP)-EDENT test, satisfaction with dental prosthesis and chewing efficiency using questionnaires and a Visual Analogue Scale (VAS) were evaluated twice: after they had received mandibular complete dentures, and again after they had received mandibular overdentures. Results: After 1 year, no overdenture failed and 2 implants did not osseointegrate, resulting in a 98.3% success rate for loaded implants and 95.9% for total implants used (3 out of 123 were not loaded due to fracture). A flap surgical approach was performed in 7 patients, 3 implants fractured during insertion, 3 overdentures fractured, occlusion balancing was necessary for 11 dentures and relining for 8. Implant rehabilitation provided significant improvement in quality of life, stability, comfort, chewing and speaking ability while no significant differences were found in quality of maintenance of hygiene and for aesthetics. Conclusions: Mini dental implant retained overdentures can be a successful therapeutic procedure for treating mandibular edentulism that improves quality of life, patient satisfaction and chewing ability in patients wearing maxillary dentures. Longer follow-ups are needed to validate this therapy in the medium and long-term.",
publisher = "Quintessence Publishing Co., Ltd",
journal = "European Journal of Oral Implantology",
title = "A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants",
volume = "5",
number = "4",
pages = "367-379",
url = "https://hdl.handle.net/21.15107/rcub_smile_1687"
}

Šćepanović, M., Luis Calvo-Guirado, J., Marković, A., Delgado-Ruiz, R., Todorović, A., Miličić, B.,& Mišić, T.. (2012). A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants. in European Journal of Oral Implantology
Quintessence Publishing Co., Ltd., 5(4), 367-379.
https://hdl.handle.net/21.15107/rcub_smile_1687

Šćepanović M, Luis Calvo-Guirado J, Marković A, Delgado-Ruiz R, Todorović A, Miličić B, Mišić T. A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants. in European Journal of Oral Implantology. 2012;5(4):367-379.
https://hdl.handle.net/21.15107/rcub_smile_1687 .

Šćepanović, Miodrag, Luis Calvo-Guirado, Jose, Marković, Aleksa, Delgado-Ruiz, Rafael, Todorović, Aleksandar, Miličić, Biljana, Mišić, Tijana, "A 1-year prospective cohort study on mandibular overdentures retained by mini dental implants" in European Journal of Oral Implantology, 5, no. 4 (2012):367-379,
https://hdl.handle.net/21.15107/rcub_smile_1687 .

TY  - JOUR
AU  - Dražić, Radojica
AU  - Jurišić, Milan
AU  - Marković, Aleksa
AU  - Čolić, Snježana
AU  - Gačić, Bojan
AU  - Stojčev-Stajčić, Ljiljana
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1664
AB  - Introduction. Clinical presentation of acute odontogenic infections may vary, while adequate evaluation of its severity is of great importance for determination of appropriate and effective therapy. Objective. The aim of the present study was to monitor changes of C-reactive protein (CRP) levels, to correlate its values with symptoms of different acute odontogenic infections (AOI), and to monitor the effectiveness of the applied therapy. Methods. Fifty-four patients with AOI were included in the study. Eighteen patients with good drainage and normal body temperature were treated only by surgical incision without using antibiotics. Twenty-two patients with poor drainage after incision and normal body temperature were treated by surgical incision and antibiotics. Fourteen patients with elevated body temperature were treated by incision and antibiotics, irrespective of the quality of the drainage. CRP levels were measured on admission, on the 3rd and 7th day after therapy initiation. Results. On admission CRP levels were higher in AOI with elevated body temperature compared to poorly and well-drained AOI. There were no differences in CRP levels between well and poorly drained AOI on admission. On the 3rd day, a decline in the CRP levels was evident in all three groups of patients, and there was no difference among the groups. On the 7th day, the CRP levels normalized in all groups. Conclusion. CRP levels correlate well with the severity and resolution of AOI and could be used as a reliable parameter in monitoring the effectiveness of AOI therapy.
AB  - Uvod. Klinička slika akutne dentogene infekcije (ADI) je raznolika, a pravilna procena težine ADI od velikog značaja za određivanje odgovarajuće i efikasne terapije. Cilj rada. Cilj rada je bio da se uporede vrednosti i promene nivoa C-reaktivnog proteina (CRP) s kliničkim simptomima ADI različitog stepena težine tokom lečenja bolesnika, te na taj način utvrdi efikasnost primenjene terapije. Metode rada. Istraživanjem su obuhvaćena 54 pacijenta sa ADI. Osamnaest pacijenata sa dobrom drenažom nakon incizije i normalnom telesnom temperaturom lečeno je bez antibiotika. Dvadeset dva pacijenta s lošom drenažom nakon incizije i normalnom telesnom temperaturom lečena su incizijom i antibioticima. Četrnaest pacijenata s povišenom telesnom temperaturom lečeno je incizijom i antibioticima bez obzira na kvalitet drenaže. Nivo CRP je meren na prijemu, trećeg i sedmog dana od početka primene terapije. Rezultati. Na početku lečenja nivo CRP bio je veći kod bolesnika s povišenom telesnom temperaturom u poređenju s ostalim ispitanicima. Na početku lečenja nije bilo razlike u nivou CRP između ispitanika sa dobrom i lošom drenažom. Trećeg dana uočeno je smanjenje nivoa CRP u sve tri grupe ispitanika bez ikakve razlike. Sedmog dana nivo CRP se normalizovao u svim grupama. Zaključak. Nivo CRP je u dobroj korelaciji sa stepenom težine i povlačenjem dentogene infekcije, tako da može biti pouzdan parametar u proceni efikasnosti lečenja ADI.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - C-reactive protein as an inflammatory marker in monitoring therapy effectiveness of acute odontogenic infections
T1  - C-reaktivni protein kao inflamatorni marker u proceni efikasnosti lečenja akutnih dentogenih infekcija
VL  - 139
IS  - 7-8
SP  - 446
EP  - 451
DO  - 10.2298/SARH1108446D
ER  - 

@article{
author = "Dražić, Radojica and Jurišić, Milan and Marković, Aleksa and Čolić, Snježana and Gačić, Bojan and Stojčev-Stajčić, Ljiljana",
year = "2011",
abstract = "Introduction. Clinical presentation of acute odontogenic infections may vary, while adequate evaluation of its severity is of great importance for determination of appropriate and effective therapy. Objective. The aim of the present study was to monitor changes of C-reactive protein (CRP) levels, to correlate its values with symptoms of different acute odontogenic infections (AOI), and to monitor the effectiveness of the applied therapy. Methods. Fifty-four patients with AOI were included in the study. Eighteen patients with good drainage and normal body temperature were treated only by surgical incision without using antibiotics. Twenty-two patients with poor drainage after incision and normal body temperature were treated by surgical incision and antibiotics. Fourteen patients with elevated body temperature were treated by incision and antibiotics, irrespective of the quality of the drainage. CRP levels were measured on admission, on the 3rd and 7th day after therapy initiation. Results. On admission CRP levels were higher in AOI with elevated body temperature compared to poorly and well-drained AOI. There were no differences in CRP levels between well and poorly drained AOI on admission. On the 3rd day, a decline in the CRP levels was evident in all three groups of patients, and there was no difference among the groups. On the 7th day, the CRP levels normalized in all groups. Conclusion. CRP levels correlate well with the severity and resolution of AOI and could be used as a reliable parameter in monitoring the effectiveness of AOI therapy., Uvod. Klinička slika akutne dentogene infekcije (ADI) je raznolika, a pravilna procena težine ADI od velikog značaja za određivanje odgovarajuće i efikasne terapije. Cilj rada. Cilj rada je bio da se uporede vrednosti i promene nivoa C-reaktivnog proteina (CRP) s kliničkim simptomima ADI različitog stepena težine tokom lečenja bolesnika, te na taj način utvrdi efikasnost primenjene terapije. Metode rada. Istraživanjem su obuhvaćena 54 pacijenta sa ADI. Osamnaest pacijenata sa dobrom drenažom nakon incizije i normalnom telesnom temperaturom lečeno je bez antibiotika. Dvadeset dva pacijenta s lošom drenažom nakon incizije i normalnom telesnom temperaturom lečena su incizijom i antibioticima. Četrnaest pacijenata s povišenom telesnom temperaturom lečeno je incizijom i antibioticima bez obzira na kvalitet drenaže. Nivo CRP je meren na prijemu, trećeg i sedmog dana od početka primene terapije. Rezultati. Na početku lečenja nivo CRP bio je veći kod bolesnika s povišenom telesnom temperaturom u poređenju s ostalim ispitanicima. Na početku lečenja nije bilo razlike u nivou CRP između ispitanika sa dobrom i lošom drenažom. Trećeg dana uočeno je smanjenje nivoa CRP u sve tri grupe ispitanika bez ikakve razlike. Sedmog dana nivo CRP se normalizovao u svim grupama. Zaključak. Nivo CRP je u dobroj korelaciji sa stepenom težine i povlačenjem dentogene infekcije, tako da može biti pouzdan parametar u proceni efikasnosti lečenja ADI.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "C-reactive protein as an inflammatory marker in monitoring therapy effectiveness of acute odontogenic infections, C-reaktivni protein kao inflamatorni marker u proceni efikasnosti lečenja akutnih dentogenih infekcija",
volume = "139",
number = "7-8",
pages = "446-451",
doi = "10.2298/SARH1108446D"
}

Dražić, R., Jurišić, M., Marković, A., Čolić, S., Gačić, B.,& Stojčev-Stajčić, L.. (2011). C-reactive protein as an inflammatory marker in monitoring therapy effectiveness of acute odontogenic infections. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 139(7-8), 446-451.
https://doi.org/10.2298/SARH1108446D

Dražić R, Jurišić M, Marković A, Čolić S, Gačić B, Stojčev-Stajčić L. C-reactive protein as an inflammatory marker in monitoring therapy effectiveness of acute odontogenic infections. in Srpski arhiv za celokupno lekarstvo. 2011;139(7-8):446-451.
doi:10.2298/SARH1108446D .

Dražić, Radojica, Jurišić, Milan, Marković, Aleksa, Čolić, Snježana, Gačić, Bojan, Stojčev-Stajčić, Ljiljana, "C-reactive protein as an inflammatory marker in monitoring therapy effectiveness of acute odontogenic infections" in Srpski arhiv za celokupno lekarstvo, 139, no. 7-8 (2011):446-451,
https://doi.org/10.2298/SARH1108446D . .