Petković-Ćurčin, Aleksandra

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  • Petković-Ćurčin, Aleksandra (5)
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Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid

Taso, Ervin; Stefanović, Vladimir; Stevanović, Ivana; Vojvodić, Danilo; Topić, Aleksandra; Petković-Ćurčin, Aleksandra; Obradović-Đuričić, Kosovka; Marković, Aleksa; Đukić, Mirjana; Vujanović, Dragana

(Hindawi Ltd, London, 2018)

TY  - JOUR
AU  - Taso, Ervin
AU  - Stefanović, Vladimir
AU  - Stevanović, Ivana
AU  - Vojvodić, Danilo
AU  - Topić, Aleksandra
AU  - Petković-Ćurčin, Aleksandra
AU  - Obradović-Đuričić, Kosovka
AU  - Marković, Aleksa
AU  - Đukić, Mirjana
AU  - Vujanović, Dragana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2324
AB  - Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine & Cellular Longevity
T1  - Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid
VL  - 2018
DO  - 10.1155/2018/1823189
ER  - 
@article{
author = "Taso, Ervin and Stefanović, Vladimir and Stevanović, Ivana and Vojvodić, Danilo and Topić, Aleksandra and Petković-Ćurčin, Aleksandra and Obradović-Đuričić, Kosovka and Marković, Aleksa and Đukić, Mirjana and Vujanović, Dragana",
year = "2018",
abstract = "Biocompatibility of dental materials (DM) can be evaluated by gingival crevicular fluid (GCF) oxidative stress (OS) status. The goal of the study was to ascertain influence of dental caries degree, teeth position, and type and amount of applied DM on GCF OS profile. For this purpose, we tested six DMs that were sealed in one session: amalgam (Amg), composites: Tetric EvoCeram and Beautifil (BF), phosphate cement-zinc phosphate and polycarboxylate cements zinc polycarboxylate cements, and glass ionomer cement (GIC). The study included 88 dental outpatients. Follow-up was scheduled at 7th and 30th day. Oxidative stress parameters (malondialdehyde (MDA) and glutathione (GSH) levels and total superoxide dismutase (tSOD) activity) were measured before (0th day) and after the treatment (7th and 30th day) in GCF. Control teeth were mirror-positioned healthy teeth. The DM accomplished the following effects (listed in descending order): increase of GSH in GCF was realized by ZPoC > BF > GIC > Amg; tSOD activity increase by ZPoC > BF > Amg; and MDA decrease by ZPoC > ZPhC > Amg > TEC. Dental caries provokes insignificant rise of OS in GCF. ZPoC and ZPhC showed the highest antioxidant effect, contrary to GIC. Restorations with antioxidant properties may reduce gum diseases initiated by caries lesion, what is of great clinical relevance in dentistry.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine & Cellular Longevity",
title = "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid",
volume = "2018",
doi = "10.1155/2018/1823189"
}
Taso, E., Stefanović, V., Stevanović, I., Vojvodić, D., Topić, A., Petković-Ćurčin, A., Obradović-Đuričić, K., Marković, A., Đukić, M.,& Vujanović, D.. (2018). Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine & Cellular Longevity
Hindawi Ltd, London., 2018.
https://doi.org/10.1155/2018/1823189
Taso E, Stefanović V, Stevanović I, Vojvodić D, Topić A, Petković-Ćurčin A, Obradović-Đuričić K, Marković A, Đukić M, Vujanović D. Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid. in Oxidative Medicine & Cellular Longevity. 2018;2018.
doi:10.1155/2018/1823189 .
Taso, Ervin, Stefanović, Vladimir, Stevanović, Ivana, Vojvodić, Danilo, Topić, Aleksandra, Petković-Ćurčin, Aleksandra, Obradović-Đuričić, Kosovka, Marković, Aleksa, Đukić, Mirjana, Vujanović, Dragana, "Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid" in Oxidative Medicine & Cellular Longevity, 2018 (2018),
https://doi.org/10.1155/2018/1823189 . .
9
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10

Bone loss biomarkers associated with peri-implantitis. A cross-sectional study

Rakić, Mia; Leković, Vojislav; Nikolić-Jakoba, Nataša; Vojvodić, Danilo; Petković-Ćurčin, Aleksandra; Sanz, Mariano

(Wiley, Hoboken, 2013)

TY  - JOUR
AU  - Rakić, Mia
AU  - Leković, Vojislav
AU  - Nikolić-Jakoba, Nataša
AU  - Vojvodić, Danilo
AU  - Petković-Ćurčin, Aleksandra
AU  - Sanz, Mariano
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1824
AB  - Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.
PB  - Wiley, Hoboken
T2  - Clinical Oral Implants Research
T1  - Bone loss biomarkers associated with peri-implantitis. A cross-sectional study
VL  - 24
IS  - 10
SP  - 1110
EP  - 1116
DO  - 10.1111/j.1600-0501.2012.02518.x
ER  - 
@article{
author = "Rakić, Mia and Leković, Vojislav and Nikolić-Jakoba, Nataša and Vojvodić, Danilo and Petković-Ćurčin, Aleksandra and Sanz, Mariano",
year = "2013",
abstract = "Aim To investigate the levels of biomarkers associated with osteoclastogenesis in patients suffering peri-implantitis and to compare them with levels in healthy peri-implant sites and severe chronic periodontitis. Material and methods Peri-implant/gingival crevicular fluid samples and clinical parameters including: bleeding on probing, modified Plaque Index (PlI), pocket depth and clinical attachment level were collected from 70 patients (23 with peri-implantitis, 25 with healthy peri-implant tissues and 22 with severe chronic periodontitis). The concentrations of sRANKL, RANK and OPG were evaluated using enzyme-linked immunosorbent assays; they were compared between the groups and correlated with the clinical findings. Results sRANKL (P=0.01), RANK (P=0.01) and OPG (P=0.03) concentrations were significantly higher in peri-implantitis sites when compared to those in healthy implant sites, although differences in the sRANKL/OPG ratio were not statistically significant. In these sites all three markers were significantly correlated with the clinical parameters, with exception of OPG/PI correlation that remained insignificant (P=0.121). When comparing peri-implantitis and periodontitis findings, RANK was significantly higher in peri-implantitis sites whereas, sRANKL (P=0.03) and sRANKL/OPG ratio (P=0.004) were significantly higher in periodontitis sites. Among periodontitis and healthy implant sites the same differences have been observed for both sRANKL (P=0.000) and sRANKL/OPG ratio (P=0.000), furthermore RANK was higher in periodontitis sites as well (P=0.010). Conclusion The findings of this preliminary study on a relatively small sample size suggest that the PICF levels of biomarkers sRANKL, RANK, and OPG are associated with peri-implant tissue destruction and the pattern of these biomarkers differed when compared to periodontitis.",
publisher = "Wiley, Hoboken",
journal = "Clinical Oral Implants Research",
title = "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study",
volume = "24",
number = "10",
pages = "1110-1116",
doi = "10.1111/j.1600-0501.2012.02518.x"
}
Rakić, M., Leković, V., Nikolić-Jakoba, N., Vojvodić, D., Petković-Ćurčin, A.,& Sanz, M.. (2013). Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research
Wiley, Hoboken., 24(10), 1110-1116.
https://doi.org/10.1111/j.1600-0501.2012.02518.x
Rakić M, Leković V, Nikolić-Jakoba N, Vojvodić D, Petković-Ćurčin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A cross-sectional study. in Clinical Oral Implants Research. 2013;24(10):1110-1116.
doi:10.1111/j.1600-0501.2012.02518.x .
Rakić, Mia, Leković, Vojislav, Nikolić-Jakoba, Nataša, Vojvodić, Danilo, Petković-Ćurčin, Aleksandra, Sanz, Mariano, "Bone loss biomarkers associated with peri-implantitis. A cross-sectional study" in Clinical Oral Implants Research, 24, no. 10 (2013):1110-1116,
https://doi.org/10.1111/j.1600-0501.2012.02518.x . .
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Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis

Rakić, Mia; Nikolić-Jakoba, Nataša; Struillou, Xavier; Petković-Ćurčin, Aleksandra; Stamatović, Novak; Matić, Smiljka; Janković, Saša; Aleksić, Zoran; Vasilić, Đurđa; Leković, Vojislav; Vojvodić, Danilo

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2013)

TY  - JOUR
AU  - Rakić, Mia
AU  - Nikolić-Jakoba, Nataša
AU  - Struillou, Xavier
AU  - Petković-Ćurčin, Aleksandra
AU  - Stamatović, Novak
AU  - Matić, Smiljka
AU  - Janković, Saša
AU  - Aleksić, Zoran
AU  - Vasilić, Đurđa
AU  - Leković, Vojislav
AU  - Vojvodić, Danilo
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1778
AB  - Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies.
AB  - Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis
T1  - Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa
VL  - 70
IS  - 4
SP  - 346
EP  - 351
DO  - 10.2298/VSP1304346R
ER  - 
@article{
author = "Rakić, Mia and Nikolić-Jakoba, Nataša and Struillou, Xavier and Petković-Ćurčin, Aleksandra and Stamatović, Novak and Matić, Smiljka and Janković, Saša and Aleksić, Zoran and Vasilić, Đurđa and Leković, Vojislav and Vojvodić, Danilo",
year = "2013",
abstract = "Background/Aim. Peri-implantitis presents inflammatory process that affects soft and hard supporting tissues of osseointegrated implant based on inflammatory osteoclastogenesis. The aim of this study was to investigate whether receptor activator of nuclear factor kappa B (RANK) concentrations in peri-implant crevicular fluid could be associated with clinical parameters that reflect inflammatory nature of peri-implantitis. Methods. The study included 67 patients, 22 with diagnosed peri-implantitis, 22 persons with healthy peri-implant tissues and 23 patients with periodontitis. Clinical parameters from each patient were recorded and samples of peri-implant/gingival crevicular fluid were collected for the enzyme-linked immunosorbent assay (ELISA) analysis. Results. RANK concentration was significantly increased in samples from the patients with periimplantitis when compared to healthy implants (p  lt  0.0001), where the average levels were 9 times higher. At the same time RANK concentration was significantly higher in periimplantitis than in periodontitis sites (p  lt  0.0001). In implant patients pocket depths and bleeding on probing values were positively associated with high RANK concentrations (p  lt  0.0001). Conclusion. These results revealed association of increased RANK concentration in samples of periimplant/ gingival crevicular fluid with peri-implant inflammation and suggests that RANK could be a pathologic determinant of peri-implantitis, thereby a potential parameter in assessment of peri-implant tissue inflammation and a potential target in designing treatment strategies., Uvod/Cilj. Periimplantitis predstavlja inflamatorni proces koji zahvata meko i tvrdo potporno tkivo osteointegrisanog implantata, i zasnovan je na inflamatornoj osteoklastogenezi. Cilj studije bio je da se utvrdi povezanost koncentracije receptora aktivatora nuklearnog faktora kapa-B (RANK), kao glavnog receptora osteoklastnog metabolizma, sa kliničkim parametrima periimplantitisa. Metode. Studija je uključila 67 sistemski zdravih pacijenata (22 sa periimplantitisom, 22 sa zdravim implantatima i 23 sa periodontopatijom). Pacijentima su mereni klinički parametri i uziman je uzorak periimplantne/gingivalne tečnosti za određivanje koncentracije RANK-a ELISA metodom. Rezultati. Koncentracija RANK-a bila je značajno povišena kod periimplantitisa u odnosu na zdrave implantate (p  lt  0,0001), gde je srednja vrednost koncentracije bila 9 puta veća. Istovremeno, RANK je bio značajno viši kod periimplantitisa nego kod parodontopatije (p  lt  0,0001). U grupi sa implantatima dubina periodontalnog džepa i krvarenje na probu bili su pozitivno udruženi sa visokim vrednostima RANK-a (p  lt  0,0001). Zaključak. Rezultati istraživanja pokazuju udruženost povišenosti koncentracije RANK-a sa periimplantnom inflamacijom i navodi na zaključak da bi RANK mogao da bude patološka determinanta periimplantitisa, a time i potencijalni parametar za praćenje inflamacije periimplantnog tkiva i potencijalni cilj za pravljenje terapijskih strategija.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis, Receptor aktivatora nuklearnog faktora kapa B kao činilac periimplantitisa",
volume = "70",
number = "4",
pages = "346-351",
doi = "10.2298/VSP1304346R"
}
Rakić, M., Nikolić-Jakoba, N., Struillou, X., Petković-Ćurčin, A., Stamatović, N., Matić, S., Janković, S., Aleksić, Z., Vasilić, Đ., Leković, V.,& Vojvodić, D.. (2013). Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(4), 346-351.
https://doi.org/10.2298/VSP1304346R
Rakić M, Nikolić-Jakoba N, Struillou X, Petković-Ćurčin A, Stamatović N, Matić S, Janković S, Aleksić Z, Vasilić Đ, Leković V, Vojvodić D. Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis. in Vojnosanitetski pregled. 2013;70(4):346-351.
doi:10.2298/VSP1304346R .
Rakić, Mia, Nikolić-Jakoba, Nataša, Struillou, Xavier, Petković-Ćurčin, Aleksandra, Stamatović, Novak, Matić, Smiljka, Janković, Saša, Aleksić, Zoran, Vasilić, Đurđa, Leković, Vojislav, Vojvodić, Danilo, "Receptor activator of nuclear factor kappa B (RANK) as a determinant of peri-implantitis" in Vojnosanitetski pregled, 70, no. 4 (2013):346-351,
https://doi.org/10.2298/VSP1304346R . .
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Cytokines in pathogenesis of peri-implantitis

Petković-Ćurčin, Aleksandra; Matić, Smiljana; Vojvodić, Danilo; Stamatović, Novak; Todorović, Tatjana

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2011)

TY  - JOUR
AU  - Petković-Ćurčin, Aleksandra
AU  - Matić, Smiljana
AU  - Vojvodić, Danilo
AU  - Stamatović, Novak
AU  - Todorović, Tatjana
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1649
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Cytokines in pathogenesis of peri-implantitis
T1  - Uloga citokina u patogenezi periimplantitisa
VL  - 68
IS  - 5
SP  - 435
EP  - 440
DO  - 10.2298/VSP1105435P
ER  - 
@article{
author = "Petković-Ćurčin, Aleksandra and Matić, Smiljana and Vojvodić, Danilo and Stamatović, Novak and Todorović, Tatjana",
year = "2011",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Cytokines in pathogenesis of peri-implantitis, Uloga citokina u patogenezi periimplantitisa",
volume = "68",
number = "5",
pages = "435-440",
doi = "10.2298/VSP1105435P"
}
Petković-Ćurčin, A., Matić, S., Vojvodić, D., Stamatović, N.,& Todorović, T.. (2011). Cytokines in pathogenesis of peri-implantitis. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 68(5), 435-440.
https://doi.org/10.2298/VSP1105435P
Petković-Ćurčin A, Matić S, Vojvodić D, Stamatović N, Todorović T. Cytokines in pathogenesis of peri-implantitis. in Vojnosanitetski pregled. 2011;68(5):435-440.
doi:10.2298/VSP1105435P .
Petković-Ćurčin, Aleksandra, Matić, Smiljana, Vojvodić, Danilo, Stamatović, Novak, Todorović, Tatjana, "Cytokines in pathogenesis of peri-implantitis" in Vojnosanitetski pregled, 68, no. 5 (2011):435-440,
https://doi.org/10.2298/VSP1105435P . .
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Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication

Todorović, Tatjana; Vujanović, Dragana; Dožić, Ivan; Petković-Ćurčin, Aleksandra

(2008)

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Vujanović, Dragana
AU  - Dožić, Ivan
AU  - Petković-Ćurčin, Aleksandra
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1441
AB  - Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.
T2  - Magnesium Research
T1  - Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication
VL  - 21
IS  - 1
SP  - 43
EP  - 50
DO  - 10.1684/mrh.2008.0122
ER  - 
@article{
author = "Todorović, Tatjana and Vujanović, Dragana and Dožić, Ivan and Petković-Ćurčin, Aleksandra",
year = "2008",
abstract = "Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.",
journal = "Magnesium Research",
title = "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication",
volume = "21",
number = "1",
pages = "43-50",
doi = "10.1684/mrh.2008.0122"
}
Todorović, T., Vujanović, D., Dožić, I.,& Petković-Ćurčin, A.. (2008). Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research, 21(1), 43-50.
https://doi.org/10.1684/mrh.2008.0122
Todorović T, Vujanović D, Dožić I, Petković-Ćurčin A. Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research. 2008;21(1):43-50.
doi:10.1684/mrh.2008.0122 .
Todorović, Tatjana, Vujanović, Dragana, Dožić, Ivan, Petković-Ćurčin, Aleksandra, "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication" in Magnesium Research, 21, no. 1 (2008):43-50,
https://doi.org/10.1684/mrh.2008.0122 . .
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