Pešić, Zoran

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orcid::0000-0003-3783-8053
  • Pešić, Zoran (6)
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Author's Bibliography

Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study

Pajić, Srbislav; Antić, Svetlana; Vukicević, Arso M.; Đorđević, Nenad; Jovicić, Gordana; Savić, Živorad; Saveljić, Igor; Janović, Aleksa; Pešić, Zoran; Đurić, Marija; Filipović, Nenad

(Frontiers Media Sa, Lausanne, 2017)

TY  - JOUR
AU  - Pajić, Srbislav
AU  - Antić, Svetlana
AU  - Vukicević, Arso M.
AU  - Đorđević, Nenad
AU  - Jovicić, Gordana
AU  - Savić, Živorad
AU  - Saveljić, Igor
AU  - Janović, Aleksa
AU  - Pešić, Zoran
AU  - Đurić, Marija
AU  - Filipović, Nenad
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2215
AB  - Anatomy of frontal sinuses varies individually, from differences in volume and shape to a rare case when the sinuses are absent. However, there are scarce data related to influence of these variations on impact generated fracture pattern. Therefore, the aim of this study was to analyse the influence of frontal sinus volume on the stress distribution and fracture pattern in the frontal region. The study included four representative Finite Element models of the skull. Reference model was built on the basis of computed tomography scans of a human head with normally developed frontal sinuses. By modifying the reference model, three additional models were generated: a model without sinuses, with hypoplasic, and with hyperplasic sinuses. A 7.7 kN force was applied perpendicularly to the forehead of each model, in order to simulate a frontal impact. The results demonstrated that the distribution of impact stress in frontal region depends on the frontal sinus volume. The anterior sinus wall showed the highest fragility in case with hyperplasic sinuses, whereas posterior wall/inner plate showed more fragility in cases with hypoplasic and undeveloped sinuses. Well-developed frontal sinusesmight, through absorption of the impact energy by anterior wall, protect the posterior wall and intracranial contents.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Physiology
T1  - Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study
VL  - 8
DO  - 10.3389/fphys.2017.00493
ER  - 
@article{
author = "Pajić, Srbislav and Antić, Svetlana and Vukicević, Arso M. and Đorđević, Nenad and Jovicić, Gordana and Savić, Živorad and Saveljić, Igor and Janović, Aleksa and Pešić, Zoran and Đurić, Marija and Filipović, Nenad",
year = "2017",
abstract = "Anatomy of frontal sinuses varies individually, from differences in volume and shape to a rare case when the sinuses are absent. However, there are scarce data related to influence of these variations on impact generated fracture pattern. Therefore, the aim of this study was to analyse the influence of frontal sinus volume on the stress distribution and fracture pattern in the frontal region. The study included four representative Finite Element models of the skull. Reference model was built on the basis of computed tomography scans of a human head with normally developed frontal sinuses. By modifying the reference model, three additional models were generated: a model without sinuses, with hypoplasic, and with hyperplasic sinuses. A 7.7 kN force was applied perpendicularly to the forehead of each model, in order to simulate a frontal impact. The results demonstrated that the distribution of impact stress in frontal region depends on the frontal sinus volume. The anterior sinus wall showed the highest fragility in case with hyperplasic sinuses, whereas posterior wall/inner plate showed more fragility in cases with hypoplasic and undeveloped sinuses. Well-developed frontal sinusesmight, through absorption of the impact energy by anterior wall, protect the posterior wall and intracranial contents.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Physiology",
title = "Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study",
volume = "8",
doi = "10.3389/fphys.2017.00493"
}
Pajić, S., Antić, S., Vukicević, A. M., Đorđević, N., Jovicić, G., Savić, Ž., Saveljić, I., Janović, A., Pešić, Z., Đurić, M.,& Filipović, N.. (2017). Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study. in Frontiers in Physiology
Frontiers Media Sa, Lausanne., 8.
https://doi.org/10.3389/fphys.2017.00493
Pajić S, Antić S, Vukicević AM, Đorđević N, Jovicić G, Savić Ž, Saveljić I, Janović A, Pešić Z, Đurić M, Filipović N. Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study. in Frontiers in Physiology. 2017;8.
doi:10.3389/fphys.2017.00493 .
Pajić, Srbislav, Antić, Svetlana, Vukicević, Arso M., Đorđević, Nenad, Jovicić, Gordana, Savić, Živorad, Saveljić, Igor, Janović, Aleksa, Pešić, Zoran, Đurić, Marija, Filipović, Nenad, "Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study" in Frontiers in Physiology, 8 (2017),
https://doi.org/10.3389/fphys.2017.00493 . .
2
16
8
13

Proptosis and diplopia as consequences in trauma of craniofacial junction

Pajić, Srbislav; Boljević, Tanja; Antić, Svetlana; Mrvaljević, Milutin; Cojić, Milena; Janić, Jovan; Pešić, Zoran

(Univerzitet u Nišu, Niš, 2017)

TY  - JOUR
AU  - Pajić, Srbislav
AU  - Boljević, Tanja
AU  - Antić, Svetlana
AU  - Mrvaljević, Milutin
AU  - Cojić, Milena
AU  - Janić, Jovan
AU  - Pešić, Zoran
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2247
AB  - In the trauma of craniofacial junction, frontal sinus wall fractures take up 5-15% of all facial bone fractures. The most common mechanism of their occurrence comes as a result of the action of high-energy impact force on the frontal area. Treatment of the injuries in frontal-orbital-ethmoidal regions largely depends on the responsible experts (otolaryngologist, maxillofacial surgeon or neurosurgeon) in all cases, because of the implementation of diverse surgical technics in order to achieve the best possible outcome for the patient. Bearing in mind the complex anatomical features of this region, it is clear that these procedures are often accompanied by series of possible complications, all of which are certainly neurosurgical. These can be expressed as early or late complications, and could be characterized by diverse clinical manifestations. Mucocele is formed, either due to partial obstruction of the sinus mucosa or due to the obstruction of the frontal sinus. The long term existence of mucocele and its progressive growth will result in strong pressure on the adjacent bones, and lead to their destruction followed by the process-propagation into surrounding tissues and spaces. In the further development if a bacterial contamination is detected, it will lead to the purulent inflammatory process and clinical picture of mucopyocele. In most clinical cases with complications proptosis and diplopia are dominant ophthalmic manifestations. In this paper we will present our experience in the treatment of proptosis and diplopia, as well as the ways of diagnostic evaluation in order to achieve timely diagnosis and assure swift healing of patients.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Medicine & Biology
T1  - Proptosis and diplopia as consequences in trauma of craniofacial junction
VL  - 19
IS  - 1
SP  - 38
EP  - 44
DO  - 10.22190/FUMB170517006P
ER  - 
@article{
author = "Pajić, Srbislav and Boljević, Tanja and Antić, Svetlana and Mrvaljević, Milutin and Cojić, Milena and Janić, Jovan and Pešić, Zoran",
year = "2017",
abstract = "In the trauma of craniofacial junction, frontal sinus wall fractures take up 5-15% of all facial bone fractures. The most common mechanism of their occurrence comes as a result of the action of high-energy impact force on the frontal area. Treatment of the injuries in frontal-orbital-ethmoidal regions largely depends on the responsible experts (otolaryngologist, maxillofacial surgeon or neurosurgeon) in all cases, because of the implementation of diverse surgical technics in order to achieve the best possible outcome for the patient. Bearing in mind the complex anatomical features of this region, it is clear that these procedures are often accompanied by series of possible complications, all of which are certainly neurosurgical. These can be expressed as early or late complications, and could be characterized by diverse clinical manifestations. Mucocele is formed, either due to partial obstruction of the sinus mucosa or due to the obstruction of the frontal sinus. The long term existence of mucocele and its progressive growth will result in strong pressure on the adjacent bones, and lead to their destruction followed by the process-propagation into surrounding tissues and spaces. In the further development if a bacterial contamination is detected, it will lead to the purulent inflammatory process and clinical picture of mucopyocele. In most clinical cases with complications proptosis and diplopia are dominant ophthalmic manifestations. In this paper we will present our experience in the treatment of proptosis and diplopia, as well as the ways of diagnostic evaluation in order to achieve timely diagnosis and assure swift healing of patients.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Medicine & Biology",
title = "Proptosis and diplopia as consequences in trauma of craniofacial junction",
volume = "19",
number = "1",
pages = "38-44",
doi = "10.22190/FUMB170517006P"
}
Pajić, S., Boljević, T., Antić, S., Mrvaljević, M., Cojić, M., Janić, J.,& Pešić, Z.. (2017). Proptosis and diplopia as consequences in trauma of craniofacial junction. in Facta universitatis - series: Medicine & Biology
Univerzitet u Nišu, Niš., 19(1), 38-44.
https://doi.org/10.22190/FUMB170517006P
Pajić S, Boljević T, Antić S, Mrvaljević M, Cojić M, Janić J, Pešić Z. Proptosis and diplopia as consequences in trauma of craniofacial junction. in Facta universitatis - series: Medicine & Biology. 2017;19(1):38-44.
doi:10.22190/FUMB170517006P .
Pajić, Srbislav, Boljević, Tanja, Antić, Svetlana, Mrvaljević, Milutin, Cojić, Milena, Janić, Jovan, Pešić, Zoran, "Proptosis and diplopia as consequences in trauma of craniofacial junction" in Facta universitatis - series: Medicine & Biology, 19, no. 1 (2017):38-44,
https://doi.org/10.22190/FUMB170517006P . .

Place and role of titanium mesh in reconstruction of the frontal bone after trauma

Pajić, Srbislav; Boljević, Tanja; Antić, Svetlana; Mrvaljević, Milutin; Cojić, Milena; Janić, Jovan; Pešić, Zoran

(Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar, 2017)

TY  - JOUR
AU  - Pajić, Srbislav
AU  - Boljević, Tanja
AU  - Antić, Svetlana
AU  - Mrvaljević, Milutin
AU  - Cojić, Milena
AU  - Janić, Jovan
AU  - Pešić, Zoran
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2232
AB  - The proper approach and surgical plan in solving impressive comminuted frontal bone trauma is reflected in adequate fixation of numerous fragments, which have to go through proper repositioning and osteosynthesis to achieve adequate stability of the fragments and to return the original contour of the frontal bone and/or frontal sinus walls. We carried out the restoration of the normal bone contour through a quick and easy way of treating frontal fractures using titanium 3D mesh - a technique that involves 'pulling the bone to the network' and fixing it with the mono cortical screws. We present our experience with this technique in solving the case of frontal impressive and comminuted fractures, on the material of 43 patients at the Centre for Medical Emergencies and Neurotrauma Emergency Centre of the Clinical Centre of Serbia through a retrospective cohort study accompanied with technical aspects and clinical results of this simple method application. The study was previously approved by the Ethics Committee of the Clinical Centre of Serbia. In the period of three years 43 patients had fractures in the area of the frontal bone and frontal sinus. The surveyed period was 1st January 2013 to 31st December 2016. The youngest patient was 17 and the oldest 78 years, the average age being 29 years. The main cause was traffic accidents in 29/43 (67.44%) patients, sport in 4/43 (9.30%), falling down from one's own height in 5/43 (11.63%), a fall from a height higher than 2m in 4/43 (9.30%) and machinery operation in 1/43 (2.33%). The ratio towards sex distribution was men/women 3:1. All patients were operated within the period of six days after the injury. The diagnostic evaluation of patients was made with multi slice computed tomography with 3D reconstruction (3D MDCT) pre- and postoperatively, all patients were controlled on the examinations within the follow-up period of the first 12 postoperative months. The stability of the fragments during the surgical procedure was achieved fully, the position of fragments in the reconstructive act was in satisfactory anatomic contours. The aesthetic results were satisfactory and there were no complications related to the procedure applied, such as uncontrolled bleeding from sinus infection, damage to the rear wall of the sinuses and brain. The effectiveness of the applied procedure indicated to us that we had no deformities of the forehead contour and that the full cosmetic result was achieved. The usage of the titanium 3D mesh in solving such complex impressive comminuted fractures showed as the procedure of choice because in a simple manner with good surgical approach it gives excellent results and the procedure is performed with minimal morbidity in addressing primarily comminuted fracture of the anterior wall of frontal sinus and the frontal bone.
AB  - Pravilan pristup i hirurški plan u rešavanju impresivne kominutivne traume čeone kosti ogleda se u adekvatnoj fiksaciji brojnih ulomaka koji moraju proći kroz adekvatnu repociziju i osteosintezu da bi se postigla adekvatna stabilnost ulomaka i vratila prvobitna kontura čeone kosti i/ili zidova čeonog sinusa. Obnovu normalne konture kosti sproveli smo kroz brz i jednostavan način lečenja frontalnog preloma korišćenjem titanijum 3D mesh-a. Tehnika podrazumeva 'izvući kost na mrežu' i fiksirati je monokortikalnim šrafovima. Iznosimo naša iskustva sa ovom tehnikom u slučaju rešavanja frontalne impresivne i kominutivne frakture, na bolesničkom materijalu od 43 pacijenta u Centru za zbrinjavanje urgentnih stanja i neurotraume Urgentnog centra Kliničkog Centra Srbije, kroz retrospektivnu kohortnu studiju, propraćeno kroz tehnički aspekt i kliničke rezultate primene ove jednostavne metode. Studija je prethodno odobrena od Etičkog odbora KCS. U periodu od tri godine njih 43 su imali prelome u predelu čeone kosti i čeonog sinusa. Period praćenja je od 01. januara 2013. godine do 31. decembra 2016. godine. Najmlađi bolesnik imao je 17, a najstariji 78 godina, sa prosekom 29 godina. Glavni uzrok su bile saobraćajne nesreće, kod 29/43 (67,44%) pacijenata, sport, kod 4/43 (9,30%), pad sa svoje visine, 5/43 (11,63%), pad sa visine veće od 2m, 4/43 (9,30%) i rukovanje mašinama, 1/43 (2,33%). Odnos prema polnoj distribuciji muškarci/žene je 3:1. Svi pacijenti su operisani u periodu od 6 dana posle povrede. Dijagnostička evaluacija pacijenata načinjena je multislajsnom kompjuterizovanom tomografijom sa 3D rekonstrukcijom (MDCT 3D) pre i postoperativno. Svi pacijenti su kontrolisani na pregledima kroz period praćenja od prvog do 12. postoperativnog meseca. Stabilnost fragmenata tokom operativnog zahvata postignuta je u potpunosti, pozicija fragmenata u rekonstruktivnom aktu je u zadovoljavajućim anatomskim konturama. Estetski rezultati bili su zadovoljavajući i bez komplikacija vezanih za primenjeni postupak, kao što je nekontrolisano krvarenje iz sinusa, infekcije, oštećenja zadnjeg zida sinusa i mozga. Efektivnost primenjenog postupka ukazala nam je da nismo imali deformitete konture čela i da je postignut potpun kozmetički rezultat. Primena metoda sa titanijum 3D mesh-om u rešavanju ovako složenih kominutivnih impresivnih preloma pokazala se kao postupak izbora jer na jednostavan način uz dobar hirurški pristup daje odlične rezultate, a sam postupak se izvodi uz minimalan morbiditet u rešavanju prevashodno kominutivnih preloma prednjeg zida čeonog sinusa i čeone kosti.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Place and role of titanium mesh in reconstruction of the frontal bone after trauma
T1  - Mesto i uloga titanijum mesh-a u rekonstrukciji čeonog sinusa nakon traume
VL  - 42
IS  - 1
SP  - 5
EP  - 11
DO  - 10.5937/tmg1701005P
ER  - 
@article{
author = "Pajić, Srbislav and Boljević, Tanja and Antić, Svetlana and Mrvaljević, Milutin and Cojić, Milena and Janić, Jovan and Pešić, Zoran",
year = "2017",
abstract = "The proper approach and surgical plan in solving impressive comminuted frontal bone trauma is reflected in adequate fixation of numerous fragments, which have to go through proper repositioning and osteosynthesis to achieve adequate stability of the fragments and to return the original contour of the frontal bone and/or frontal sinus walls. We carried out the restoration of the normal bone contour through a quick and easy way of treating frontal fractures using titanium 3D mesh - a technique that involves 'pulling the bone to the network' and fixing it with the mono cortical screws. We present our experience with this technique in solving the case of frontal impressive and comminuted fractures, on the material of 43 patients at the Centre for Medical Emergencies and Neurotrauma Emergency Centre of the Clinical Centre of Serbia through a retrospective cohort study accompanied with technical aspects and clinical results of this simple method application. The study was previously approved by the Ethics Committee of the Clinical Centre of Serbia. In the period of three years 43 patients had fractures in the area of the frontal bone and frontal sinus. The surveyed period was 1st January 2013 to 31st December 2016. The youngest patient was 17 and the oldest 78 years, the average age being 29 years. The main cause was traffic accidents in 29/43 (67.44%) patients, sport in 4/43 (9.30%), falling down from one's own height in 5/43 (11.63%), a fall from a height higher than 2m in 4/43 (9.30%) and machinery operation in 1/43 (2.33%). The ratio towards sex distribution was men/women 3:1. All patients were operated within the period of six days after the injury. The diagnostic evaluation of patients was made with multi slice computed tomography with 3D reconstruction (3D MDCT) pre- and postoperatively, all patients were controlled on the examinations within the follow-up period of the first 12 postoperative months. The stability of the fragments during the surgical procedure was achieved fully, the position of fragments in the reconstructive act was in satisfactory anatomic contours. The aesthetic results were satisfactory and there were no complications related to the procedure applied, such as uncontrolled bleeding from sinus infection, damage to the rear wall of the sinuses and brain. The effectiveness of the applied procedure indicated to us that we had no deformities of the forehead contour and that the full cosmetic result was achieved. The usage of the titanium 3D mesh in solving such complex impressive comminuted fractures showed as the procedure of choice because in a simple manner with good surgical approach it gives excellent results and the procedure is performed with minimal morbidity in addressing primarily comminuted fracture of the anterior wall of frontal sinus and the frontal bone., Pravilan pristup i hirurški plan u rešavanju impresivne kominutivne traume čeone kosti ogleda se u adekvatnoj fiksaciji brojnih ulomaka koji moraju proći kroz adekvatnu repociziju i osteosintezu da bi se postigla adekvatna stabilnost ulomaka i vratila prvobitna kontura čeone kosti i/ili zidova čeonog sinusa. Obnovu normalne konture kosti sproveli smo kroz brz i jednostavan način lečenja frontalnog preloma korišćenjem titanijum 3D mesh-a. Tehnika podrazumeva 'izvući kost na mrežu' i fiksirati je monokortikalnim šrafovima. Iznosimo naša iskustva sa ovom tehnikom u slučaju rešavanja frontalne impresivne i kominutivne frakture, na bolesničkom materijalu od 43 pacijenta u Centru za zbrinjavanje urgentnih stanja i neurotraume Urgentnog centra Kliničkog Centra Srbije, kroz retrospektivnu kohortnu studiju, propraćeno kroz tehnički aspekt i kliničke rezultate primene ove jednostavne metode. Studija je prethodno odobrena od Etičkog odbora KCS. U periodu od tri godine njih 43 su imali prelome u predelu čeone kosti i čeonog sinusa. Period praćenja je od 01. januara 2013. godine do 31. decembra 2016. godine. Najmlađi bolesnik imao je 17, a najstariji 78 godina, sa prosekom 29 godina. Glavni uzrok su bile saobraćajne nesreće, kod 29/43 (67,44%) pacijenata, sport, kod 4/43 (9,30%), pad sa svoje visine, 5/43 (11,63%), pad sa visine veće od 2m, 4/43 (9,30%) i rukovanje mašinama, 1/43 (2,33%). Odnos prema polnoj distribuciji muškarci/žene je 3:1. Svi pacijenti su operisani u periodu od 6 dana posle povrede. Dijagnostička evaluacija pacijenata načinjena je multislajsnom kompjuterizovanom tomografijom sa 3D rekonstrukcijom (MDCT 3D) pre i postoperativno. Svi pacijenti su kontrolisani na pregledima kroz period praćenja od prvog do 12. postoperativnog meseca. Stabilnost fragmenata tokom operativnog zahvata postignuta je u potpunosti, pozicija fragmenata u rekonstruktivnom aktu je u zadovoljavajućim anatomskim konturama. Estetski rezultati bili su zadovoljavajući i bez komplikacija vezanih za primenjeni postupak, kao što je nekontrolisano krvarenje iz sinusa, infekcije, oštećenja zadnjeg zida sinusa i mozga. Efektivnost primenjenog postupka ukazala nam je da nismo imali deformitete konture čela i da je postignut potpun kozmetički rezultat. Primena metoda sa titanijum 3D mesh-om u rešavanju ovako složenih kominutivnih impresivnih preloma pokazala se kao postupak izbora jer na jednostavan način uz dobar hirurški pristup daje odlične rezultate, a sam postupak se izvodi uz minimalan morbiditet u rešavanju prevashodno kominutivnih preloma prednjeg zida čeonog sinusa i čeone kosti.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Place and role of titanium mesh in reconstruction of the frontal bone after trauma, Mesto i uloga titanijum mesh-a u rekonstrukciji čeonog sinusa nakon traume",
volume = "42",
number = "1",
pages = "5-11",
doi = "10.5937/tmg1701005P"
}
Pajić, S., Boljević, T., Antić, S., Mrvaljević, M., Cojić, M., Janić, J.,& Pešić, Z.. (2017). Place and role of titanium mesh in reconstruction of the frontal bone after trauma. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 42(1), 5-11.
https://doi.org/10.5937/tmg1701005P
Pajić S, Boljević T, Antić S, Mrvaljević M, Cojić M, Janić J, Pešić Z. Place and role of titanium mesh in reconstruction of the frontal bone after trauma. in Timočki medicinski glasnik. 2017;42(1):5-11.
doi:10.5937/tmg1701005P .
Pajić, Srbislav, Boljević, Tanja, Antić, Svetlana, Mrvaljević, Milutin, Cojić, Milena, Janić, Jovan, Pešić, Zoran, "Place and role of titanium mesh in reconstruction of the frontal bone after trauma" in Timočki medicinski glasnik, 42, no. 1 (2017):5-11,
https://doi.org/10.5937/tmg1701005P . .

Mucocele in the submandibular salivary gland: Case report and literature review

Pajić, Srbislav; Boljević, Tanja; Antić, Svetlana; Mrvaljević, Milutin; Cojić, Milena; Janić, Jovan; Pešić, Zoran

(Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar, 2017)

TY  - JOUR
AU  - Pajić, Srbislav
AU  - Boljević, Tanja
AU  - Antić, Svetlana
AU  - Mrvaljević, Milutin
AU  - Cojić, Milena
AU  - Janić, Jovan
AU  - Pešić, Zoran
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2231
AB  - The development and emergence of mucocele in the salivary glands is very rare. They often appear in small salivary glands and oral mucosa, while extremely rarely in major salivary glands. Current knowledge through literature review has indicated 14 detected cases in submandibular salivary gland with a mucocele entity. The occurrence and development of mucocele is related to various etiological partial obstructions or disruptions of single secretory channels of salivary glands. The mechanism of origin and development of mucocele is explained by the accumulation of mucus or extravasation within it, which is confirmed by the histopathological image. The treatment of mucocele salivary gland requires surgical treatment and such a radical approach minimises the rate of recidivism. As this is an extremely rare entity in its incidence and persistence and has been scarcely reported in literature reviews, we thought we should indicate the existence of this rare disease that has occurred in our practice. We present a 47-year-old male patient with mucocele in the left submandibulary salivary gland, with the disease duration of three years, with occasional remissions and final progressive growth, who underwent surgical treatment after MSCT examination and aspiration puncture.
AB  - Razvoj i pojava mukokela u pljuvačnim žlezdama je izuzetno retka. One se češće pojavljuju u malim pljuvačnim žlezdama i oralnoj sluznici, dok izuzetno retko u velikim pljuvačnim žlezdama. Dosadašnja saznanja kroz literaturni pregled ukazuju na otkrivena 14 slučaja u submandibularnoj pljuvačnoj žlezdi sa entitetom mukokele. Sam nastanak i razvoj mukokela vezan je etiološki za razne parcijalne opstrukcije ili poremećaje u samim izvodnim kanalima žlezde. Mehanizam nastanka i razvoja mukokela objašnjava se nagomilavanjem ili ekstravazacijom mukusa unutar nje, što histopatološka slika i potvrđuje. Sam tretman mukokela pljuvačnih žlezda zahteva hirurško zbrinjavanje i takav radikalni pristup svodi na minimum stopu recidiva. Kako je ovo izuzetno redak entitet u svojoj pojavnosti i perzistenciji, a i kroz literaturni pregled u malom obimu javljanja, smatrali smo da treba da ukažemo na postojanje ovog retkog oboljenja koje nam se kroz praksu pojavilo. Prikazujemo pacijenta starosti 47. godina sa trajanjem bolesti unazad tri godine, sa povremenim remisijama i konačnim progresivnim rastom mukokele leve submandibularne pljuvačne žlezde, kod koga se, nakon MSCT pregleda i punkcije. pristupilo operativnom tretmanu.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Mucocele in the submandibular salivary gland: Case report and literature review
T1  - Mukokela u submandibularnoj pljuvačnoj žlezdi - prikaz slučaja i literaturni pregled
VL  - 42
IS  - 1
SP  - 48
EP  - 52
DO  - 10.5937/tmg1701048P
ER  - 
@article{
author = "Pajić, Srbislav and Boljević, Tanja and Antić, Svetlana and Mrvaljević, Milutin and Cojić, Milena and Janić, Jovan and Pešić, Zoran",
year = "2017",
abstract = "The development and emergence of mucocele in the salivary glands is very rare. They often appear in small salivary glands and oral mucosa, while extremely rarely in major salivary glands. Current knowledge through literature review has indicated 14 detected cases in submandibular salivary gland with a mucocele entity. The occurrence and development of mucocele is related to various etiological partial obstructions or disruptions of single secretory channels of salivary glands. The mechanism of origin and development of mucocele is explained by the accumulation of mucus or extravasation within it, which is confirmed by the histopathological image. The treatment of mucocele salivary gland requires surgical treatment and such a radical approach minimises the rate of recidivism. As this is an extremely rare entity in its incidence and persistence and has been scarcely reported in literature reviews, we thought we should indicate the existence of this rare disease that has occurred in our practice. We present a 47-year-old male patient with mucocele in the left submandibulary salivary gland, with the disease duration of three years, with occasional remissions and final progressive growth, who underwent surgical treatment after MSCT examination and aspiration puncture., Razvoj i pojava mukokela u pljuvačnim žlezdama je izuzetno retka. One se češće pojavljuju u malim pljuvačnim žlezdama i oralnoj sluznici, dok izuzetno retko u velikim pljuvačnim žlezdama. Dosadašnja saznanja kroz literaturni pregled ukazuju na otkrivena 14 slučaja u submandibularnoj pljuvačnoj žlezdi sa entitetom mukokele. Sam nastanak i razvoj mukokela vezan je etiološki za razne parcijalne opstrukcije ili poremećaje u samim izvodnim kanalima žlezde. Mehanizam nastanka i razvoja mukokela objašnjava se nagomilavanjem ili ekstravazacijom mukusa unutar nje, što histopatološka slika i potvrđuje. Sam tretman mukokela pljuvačnih žlezda zahteva hirurško zbrinjavanje i takav radikalni pristup svodi na minimum stopu recidiva. Kako je ovo izuzetno redak entitet u svojoj pojavnosti i perzistenciji, a i kroz literaturni pregled u malom obimu javljanja, smatrali smo da treba da ukažemo na postojanje ovog retkog oboljenja koje nam se kroz praksu pojavilo. Prikazujemo pacijenta starosti 47. godina sa trajanjem bolesti unazad tri godine, sa povremenim remisijama i konačnim progresivnim rastom mukokele leve submandibularne pljuvačne žlezde, kod koga se, nakon MSCT pregleda i punkcije. pristupilo operativnom tretmanu.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Mucocele in the submandibular salivary gland: Case report and literature review, Mukokela u submandibularnoj pljuvačnoj žlezdi - prikaz slučaja i literaturni pregled",
volume = "42",
number = "1",
pages = "48-52",
doi = "10.5937/tmg1701048P"
}
Pajić, S., Boljević, T., Antić, S., Mrvaljević, M., Cojić, M., Janić, J.,& Pešić, Z.. (2017). Mucocele in the submandibular salivary gland: Case report and literature review. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 42(1), 48-52.
https://doi.org/10.5937/tmg1701048P
Pajić S, Boljević T, Antić S, Mrvaljević M, Cojić M, Janić J, Pešić Z. Mucocele in the submandibular salivary gland: Case report and literature review. in Timočki medicinski glasnik. 2017;42(1):48-52.
doi:10.5937/tmg1701048P .
Pajić, Srbislav, Boljević, Tanja, Antić, Svetlana, Mrvaljević, Milutin, Cojić, Milena, Janić, Jovan, Pešić, Zoran, "Mucocele in the submandibular salivary gland: Case report and literature review" in Timočki medicinski glasnik, 42, no. 1 (2017):48-52,
https://doi.org/10.5937/tmg1701048P . .

The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients

Pejčić, Nataša; Kesić, Ljiljana; Milašin, Jelena; Pešić, Zoran; Mirković, D.

(University of Zagreb. School of Dental Medicine, 2011)

TY  - JOUR
AU  - Pejčić, Nataša
AU  - Kesić, Ljiljana
AU  - Milašin, Jelena
AU  - Pešić, Zoran
AU  - Mirković, D.
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1676
AB  - Objective: Recent epidemiological studies have shown that individuals with periodontitis have significantly increased risk of developing coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the removal of infection and inflammatory burden of periodontitis by therapy would be accompanied by a decrease in levels of the inflammatory marker C-reactive protein and a decreased risk of coronary heart disease. The aim of the present study was to determine whether the presence of chronic periodontitis and periodontal pathogens and subsequent periodontal treatment could influence the serum levels of C-reactive protein in a Serbian cohort. Material and Methods: Fifty adults with moderate to severe periodontitis who underwent complete mouth disinfection were evaluated to determine if periodontal therapy would result in decreased periodontal infammation and lower serum levels of an inflammatory marker. Subjects underwent measuring of periodontal disease severity and serum C-reactive protein, and periodontal pathogens (Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans) at the time of the baseline visit and again 6 and 12 months after treatment. Serum levels CRP were also obtained from 25 subjects without periodontitis in a control group. Results: The levels of CRP in the serum seemed not to be lower than those reported in other population in Western European countries. There were significant changes in clinical periodontal values, CRP levels and presence of periodontal pathogens when baseline values were compared to those taken after periodontal treatment completion. Conclusion: The obtained results confirm the hypothesis that periodontal therapy may contribute to elimination of periodontal inflammation and periodontal pathogens, and reduce serum level of CRP. Periodontitis may contribute to the systemic inflammatory burden of affected individuals since it was shown that periodontal therapy may decrease presence of periodontal pathogens and inflammatory markers.
PB  - University of Zagreb. School of Dental Medicine
T2  - Acta Stomatologica Croatica
T1  - The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients
T1  - Utjecaj parodontološke terapije na C-reaktivni protein i parodontne patogene kod pacijenata s parodontopatijom
VL  - 45
IS  - 1
SP  - 14
EP  - 23
UR  - https://hdl.handle.net/21.15107/rcub_smile_1676
ER  - 
@article{
author = "Pejčić, Nataša and Kesić, Ljiljana and Milašin, Jelena and Pešić, Zoran and Mirković, D.",
year = "2011",
abstract = "Objective: Recent epidemiological studies have shown that individuals with periodontitis have significantly increased risk of developing coronary heart disease. Although the mechanism responsible for the relationship between periodontal disease and cardiovascular events is not fully understood, it is hypothesized that the removal of infection and inflammatory burden of periodontitis by therapy would be accompanied by a decrease in levels of the inflammatory marker C-reactive protein and a decreased risk of coronary heart disease. The aim of the present study was to determine whether the presence of chronic periodontitis and periodontal pathogens and subsequent periodontal treatment could influence the serum levels of C-reactive protein in a Serbian cohort. Material and Methods: Fifty adults with moderate to severe periodontitis who underwent complete mouth disinfection were evaluated to determine if periodontal therapy would result in decreased periodontal infammation and lower serum levels of an inflammatory marker. Subjects underwent measuring of periodontal disease severity and serum C-reactive protein, and periodontal pathogens (Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans) at the time of the baseline visit and again 6 and 12 months after treatment. Serum levels CRP were also obtained from 25 subjects without periodontitis in a control group. Results: The levels of CRP in the serum seemed not to be lower than those reported in other population in Western European countries. There were significant changes in clinical periodontal values, CRP levels and presence of periodontal pathogens when baseline values were compared to those taken after periodontal treatment completion. Conclusion: The obtained results confirm the hypothesis that periodontal therapy may contribute to elimination of periodontal inflammation and periodontal pathogens, and reduce serum level of CRP. Periodontitis may contribute to the systemic inflammatory burden of affected individuals since it was shown that periodontal therapy may decrease presence of periodontal pathogens and inflammatory markers.",
publisher = "University of Zagreb. School of Dental Medicine",
journal = "Acta Stomatologica Croatica",
title = "The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients, Utjecaj parodontološke terapije na C-reaktivni protein i parodontne patogene kod pacijenata s parodontopatijom",
volume = "45",
number = "1",
pages = "14-23",
url = "https://hdl.handle.net/21.15107/rcub_smile_1676"
}
Pejčić, N., Kesić, L., Milašin, J., Pešić, Z.,& Mirković, D.. (2011). The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients. in Acta Stomatologica Croatica
University of Zagreb. School of Dental Medicine., 45(1), 14-23.
https://hdl.handle.net/21.15107/rcub_smile_1676
Pejčić N, Kesić L, Milašin J, Pešić Z, Mirković D. The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients. in Acta Stomatologica Croatica. 2011;45(1):14-23.
https://hdl.handle.net/21.15107/rcub_smile_1676 .
Pejčić, Nataša, Kesić, Ljiljana, Milašin, Jelena, Pešić, Zoran, Mirković, D., "The effects of periodontal therapy on C-reactive protein and periodontal pathogens in periodontitis patients" in Acta Stomatologica Croatica, 45, no. 1 (2011):14-23,
https://hdl.handle.net/21.15107/rcub_smile_1676 .
6

Responses of the human submandibular artery to ACh and VIP

Pešić, Srđan; Radenković, Miroslav; Popović-Roganović, Jelena; Pešić, Zoran; Grbović, Leosava; Stojić, Dragica

(Sage Publications Inc., 2007)

TY  - JOUR
AU  - Pešić, Srđan
AU  - Radenković, Miroslav
AU  - Popović-Roganović, Jelena
AU  - Pešić, Zoran
AU  - Grbović, Leosava
AU  - Stojić, Dragica
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2589
AB  - Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.
PB  - Sage Publications Inc.
T2  - Journal of Dental Research
T1  - Responses of the human submandibular artery to ACh and VIP
VL  - 86
IS  - 6
SP  - 565
EP  - 570
DO  - 10.1177/154405910708600615
ER  - 
@article{
author = "Pešić, Srđan and Radenković, Miroslav and Popović-Roganović, Jelena and Pešić, Zoran and Grbović, Leosava and Stojić, Dragica",
year = "2007",
abstract = "Endothelial vasodilatory substances may play a central role in the local regulation of vascular tone. We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to ACh and VIP, using different inhibitors of endothelial vasodilation, the nitric oxide synthase inhibitor, the cyclo-oxygenase inhibitor, indomethacin, the potassium channel blocker, and 4-aminopyridine. ACh and VIP caused an endothelium- and concentration-dependent relaxation in this artery. ACh relaxation was completely blocked after the concomitant addition of N(G)-nitro-L-arginine and indomethacin. The vasorelaxant effect of ACh was not influenced by 4-aminopyridine. VIP relaxation was almost completely abolished by 4-aminopyridine, and was partly inhibited by N(G)-nitro-L-arginine, but was not affected by indomethacin. Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP.",
publisher = "Sage Publications Inc.",
journal = "Journal of Dental Research",
title = "Responses of the human submandibular artery to ACh and VIP",
volume = "86",
number = "6",
pages = "565-570",
doi = "10.1177/154405910708600615"
}
Pešić, S., Radenković, M., Popović-Roganović, J., Pešić, Z., Grbović, L.,& Stojić, D.. (2007). Responses of the human submandibular artery to ACh and VIP. in Journal of Dental Research
Sage Publications Inc.., 86(6), 565-570.
https://doi.org/10.1177/154405910708600615
Pešić S, Radenković M, Popović-Roganović J, Pešić Z, Grbović L, Stojić D. Responses of the human submandibular artery to ACh and VIP. in Journal of Dental Research. 2007;86(6):565-570.
doi:10.1177/154405910708600615 .
Pešić, Srđan, Radenković, Miroslav, Popović-Roganović, Jelena, Pešić, Zoran, Grbović, Leosava, Stojić, Dragica, "Responses of the human submandibular artery to ACh and VIP" in Journal of Dental Research, 86, no. 6 (2007):565-570,
https://doi.org/10.1177/154405910708600615 . .
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