TY  - JOUR
AU  - Toljić, Boško
AU  - Milašin, Jelena
AU  - de Luka, Silvio R.
AU  - Dragović, Gordana
AU  - Jevtović, Đorđe
AU  - Maslać, Aleksandar
AU  - Ristić-Đurović, Jasna
AU  - Trbovich, Alexander M.
PY  - 2023
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3281
AB  - We appraised the relationship between the biological and the chrono-
logical age and estimated the rate of biological aging in HIV-infected patients. Two
independent biomarkers, the relative telomere length and iron metabolism parame-
ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected
patients (control group). In our control group, telomeres of younger patients were
significantly longer than telomeres of older ones. However, in HIV-infected partici-
pants, the difference in the length of telomeres was lost. By combining the length of
telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for-
mula for determination of the aging process was developed. The life expectancy of
the healthy population was related to their biological age, and HIV-infected patients
were biologically older. The effect of antiretroviral HIV drug therapies varied with
respect to the biological aging process.
IMPORTANCE This article is focused on the dynamics of human aging. Moreover, its
interdisciplinary approach is applicable to various systems that are aging.
PB  - American Society for Microbiology
T2  - Microbiology Spectrum
T1  - HIV-Infected Patients as a Model of Aging
VL  - 11
IS  - 3
SP  - e00532-23
DO  - 10.1128/spectrum.00532-23
ER  - 

@article{
author = "Toljić, Boško and Milašin, Jelena and de Luka, Silvio R. and Dragović, Gordana and Jevtović, Đorđe and Maslać, Aleksandar and Ristić-Đurović, Jasna and Trbovich, Alexander M.",
year = "2023",
abstract = "We appraised the relationship between the biological and the chrono-
logical age and estimated the rate of biological aging in HIV-infected patients. Two
independent biomarkers, the relative telomere length and iron metabolism parame-
ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected
patients (control group). In our control group, telomeres of younger patients were
significantly longer than telomeres of older ones. However, in HIV-infected partici-
pants, the difference in the length of telomeres was lost. By combining the length of
telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for-
mula for determination of the aging process was developed. The life expectancy of
the healthy population was related to their biological age, and HIV-infected patients
were biologically older. The effect of antiretroviral HIV drug therapies varied with
respect to the biological aging process.
IMPORTANCE This article is focused on the dynamics of human aging. Moreover, its
interdisciplinary approach is applicable to various systems that are aging.",
publisher = "American Society for Microbiology",
journal = "Microbiology Spectrum",
title = "HIV-Infected Patients as a Model of Aging",
volume = "11",
number = "3",
pages = "e00532-23",
doi = "10.1128/spectrum.00532-23"
}

Toljić, B., Milašin, J., de Luka, S. R., Dragović, G., Jevtović, Đ., Maslać, A., Ristić-Đurović, J.,& Trbovich, A. M.. (2023). HIV-Infected Patients as a Model of Aging. in Microbiology Spectrum
American Society for Microbiology., 11(3), e00532-23.
https://doi.org/10.1128/spectrum.00532-23

Toljić B, Milašin J, de Luka SR, Dragović G, Jevtović Đ, Maslać A, Ristić-Đurović J, Trbovich AM. HIV-Infected Patients as a Model of Aging. in Microbiology Spectrum. 2023;11(3):e00532-23.
doi:10.1128/spectrum.00532-23 .

Toljić, Boško, Milašin, Jelena, de Luka, Silvio R., Dragović, Gordana, Jevtović, Đorđe, Maslać, Aleksandar, Ristić-Đurović, Jasna, Trbovich, Alexander M., "HIV-Infected Patients as a Model of Aging" in Microbiology Spectrum, 11, no. 3 (2023):e00532-23,
https://doi.org/10.1128/spectrum.00532-23 . .

TY  - JOUR
AU  - Dragović, Gordana
AU  - Toljić, Boško
AU  - Jevtović, Đorđe
AU  - Lukić, Relja
AU  - de Luka, Silvio R.
AU  - Trbovich, Alexander
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/3285
AB  - Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART.

Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL.

Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042).

Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.
PB  - Elsevier Inc.
T2  - Experimental Gerontology
T1  - Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy
VL  - 147
IS  - May
SP  - 111269
DO  - 10.1016/j.exger.2021.111269
ER  - 

@article{
author = "Dragović, Gordana and Toljić, Boško and Jevtović, Đorđe and Lukić, Relja and de Luka, Silvio R. and Trbovich, Alexander and Milašin, Jelena",
year = "2021",
abstract = "Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART.

Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL.

Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042).

Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.",
publisher = "Elsevier Inc.",
journal = "Experimental Gerontology",
title = "Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy",
volume = "147",
number = "May",
pages = "111269",
doi = "10.1016/j.exger.2021.111269"
}

Dragović, G., Toljić, B., Jevtović, Đ., Lukić, R., de Luka, S. R., Trbovich, A.,& Milašin, J.. (2021). Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy. in Experimental Gerontology
Elsevier Inc.., 147(May), 111269.
https://doi.org/10.1016/j.exger.2021.111269

Dragović G, Toljić B, Jevtović Đ, Lukić R, de Luka SR, Trbovich A, Milašin J. Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy. in Experimental Gerontology. 2021;147(May):111269.
doi:10.1016/j.exger.2021.111269 .

Dragović, Gordana, Toljić, Boško, Jevtović, Đorđe, Lukić, Relja, de Luka, Silvio R., Trbovich, Alexander, Milašin, Jelena, "Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy" in Experimental Gerontology, 147, no. May (2021):111269,
https://doi.org/10.1016/j.exger.2021.111269 . .

TY  - CONF
AU  - Dragović, Gordana
AU  - Dimitrijević, B.
AU  - Toljić, Boško
AU  - Milašin, Jelena
AU  - de Luka, Silvio R.
AU  - Jevtović, Đorđe
AU  - Trbovich, Alexander M.
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2314
PB  - John Wiley & Sons Ltd, Chichester
C3  - Journal of the International Aids Society
T1  - Disturbance in iron metabolism parameters: a possible marker of preterm ageing in HIV-infected males
VL  - 21
UR  - https://hdl.handle.net/21.15107/rcub_smile_2314
ER  - 

@conference{
author = "Dragović, Gordana and Dimitrijević, B. and Toljić, Boško and Milašin, Jelena and de Luka, Silvio R. and Jevtović, Đorđe and Trbovich, Alexander M.",
year = "2018",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Journal of the International Aids Society",
title = "Disturbance in iron metabolism parameters: a possible marker of preterm ageing in HIV-infected males",
volume = "21",
url = "https://hdl.handle.net/21.15107/rcub_smile_2314"
}

Dragović, G., Dimitrijević, B., Toljić, B., Milašin, J., de Luka, S. R., Jevtović, Đ.,& Trbovich, A. M.. (2018). Disturbance in iron metabolism parameters: a possible marker of preterm ageing in HIV-infected males. in Journal of the International Aids Society
John Wiley & Sons Ltd, Chichester., 21.
https://hdl.handle.net/21.15107/rcub_smile_2314

Dragović G, Dimitrijević B, Toljić B, Milašin J, de Luka SR, Jevtović Đ, Trbovich AM. Disturbance in iron metabolism parameters: a possible marker of preterm ageing in HIV-infected males. in Journal of the International Aids Society. 2018;21.
https://hdl.handle.net/21.15107/rcub_smile_2314 .

Dragović, Gordana, Dimitrijević, B., Toljić, Boško, Milašin, Jelena, de Luka, Silvio R., Jevtović, Đorđe, Trbovich, Alexander M., "Disturbance in iron metabolism parameters: a possible marker of preterm ageing in HIV-infected males" in Journal of the International Aids Society, 21 (2018),
https://hdl.handle.net/21.15107/rcub_smile_2314 .

TY  - JOUR
AU  - Toljić, Boško
AU  - Trbovich, Alexander M.
AU  - Matić-Petrović, Sanja
AU  - Kannosh, Ibrahim
AU  - Dragović, Gordana
AU  - Jevtović, Đorđe
AU  - de Luka, Silvio R.
AU  - Ristic-Đurović, Jasna L.
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2269
AB  - The importance of oral microflora composition in HIV-infected patients is well recognized. However, no studies so far have dealt with age-related changes in periodontal pathogens occurrence in HIV+ individuals. The aim of the present study was to assess and compare temporal changes of bacteria frequency in younger ( lt = 35 years) and older (>= 50 years) HIV-infected and non-infected individuals. Bacterial DNA was isolated from buccal swabs of 30 younger and 30 older subjects in both HIV+ and HIV-groups. By means of PCR the following microorganisms were detected: Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Peptostreptococcus micros, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola. Oral and periodontal examinations were performed in all subjects. The prevalence of microorganisms was significantly higher in HIV+ patients compared to controls, and their distribution showed a notable shift. The decreasing incidence in HIV-subjects was: Pi>Pm>Pg>Aa>Ec>Tf>Td whilst in HIV+ it was: Pi>Pm>Ec>Pg>Tf>Aa>Td. Oral manifestations of HIV infection were more frequent in older compared to younger patients. All measured values of clinical periodontal parameters were significantly higher in older compared to younger HIV+ patients. Ageing in HIV+ subjects is accompanied with a substantial increase and rearrangements of periodontal microflora, potentially aggravating oral and systemic health.
PB  - Luigi Ponzio e figlio Editori
T2  - New Microbiologica
T1  - Ageing with HIV - a periodontal perspective
VL  - 41
IS  - 1
SP  - 61
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_smile_2269
ER  - 

@article{
author = "Toljić, Boško and Trbovich, Alexander M. and Matić-Petrović, Sanja and Kannosh, Ibrahim and Dragović, Gordana and Jevtović, Đorđe and de Luka, Silvio R. and Ristic-Đurović, Jasna L. and Milašin, Jelena",
year = "2018",
abstract = "The importance of oral microflora composition in HIV-infected patients is well recognized. However, no studies so far have dealt with age-related changes in periodontal pathogens occurrence in HIV+ individuals. The aim of the present study was to assess and compare temporal changes of bacteria frequency in younger ( lt = 35 years) and older (>= 50 years) HIV-infected and non-infected individuals. Bacterial DNA was isolated from buccal swabs of 30 younger and 30 older subjects in both HIV+ and HIV-groups. By means of PCR the following microorganisms were detected: Aggregatibacter actinomycetemcomitans, Eikenella corrodens, Peptostreptococcus micros, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola. Oral and periodontal examinations were performed in all subjects. The prevalence of microorganisms was significantly higher in HIV+ patients compared to controls, and their distribution showed a notable shift. The decreasing incidence in HIV-subjects was: Pi>Pm>Pg>Aa>Ec>Tf>Td whilst in HIV+ it was: Pi>Pm>Ec>Pg>Tf>Aa>Td. Oral manifestations of HIV infection were more frequent in older compared to younger patients. All measured values of clinical periodontal parameters were significantly higher in older compared to younger HIV+ patients. Ageing in HIV+ subjects is accompanied with a substantial increase and rearrangements of periodontal microflora, potentially aggravating oral and systemic health.",
publisher = "Luigi Ponzio e figlio Editori",
journal = "New Microbiologica",
title = "Ageing with HIV - a periodontal perspective",
volume = "41",
number = "1",
pages = "61-66",
url = "https://hdl.handle.net/21.15107/rcub_smile_2269"
}

Toljić, B., Trbovich, A. M., Matić-Petrović, S., Kannosh, I., Dragović, G., Jevtović, Đ., de Luka, S. R., Ristic-Đurović, J. L.,& Milašin, J.. (2018). Ageing with HIV - a periodontal perspective. in New Microbiologica
Luigi Ponzio e figlio Editori., 41(1), 61-66.
https://hdl.handle.net/21.15107/rcub_smile_2269

Toljić B, Trbovich AM, Matić-Petrović S, Kannosh I, Dragović G, Jevtović Đ, de Luka SR, Ristic-Đurović JL, Milašin J. Ageing with HIV - a periodontal perspective. in New Microbiologica. 2018;41(1):61-66.
https://hdl.handle.net/21.15107/rcub_smile_2269 .

Toljić, Boško, Trbovich, Alexander M., Matić-Petrović, Sanja, Kannosh, Ibrahim, Dragović, Gordana, Jevtović, Đorđe, de Luka, Silvio R., Ristic-Đurović, Jasna L., Milašin, Jelena, "Ageing with HIV - a periodontal perspective" in New Microbiologica, 41, no. 1 (2018):61-66,
https://hdl.handle.net/21.15107/rcub_smile_2269 .