TY  - JOUR
AU  - Ašćerić, Radislav
AU  - Dimković, Nada
AU  - Trajković, Goran Z.
AU  - Ristić, Biljana S.
AU  - Janković, Aleksandar N.
AU  - Đurić, Petar
AU  - Ilijevski, Nenad S.
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2410
AB  - BackgroundPeripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD and its risk factors in patients on hemodialysis.MethodsThis cross-sectional study included 156 hemodialysis patients. Comorbidities and laboratory parameters were analyzed. Following clinical examinations, the ankle-brachial index was measured in all patients. PAD was diagnosed based on the clinical findings, ankle-brachial index  lt 0.9, and PAD symptoms.ResultsPAD was present in 55 of 156 (35.3%; 95% CI, 27.7-42.8%) patients. The patients with PAD were significantly older (6710years vs. 62 +/- 11years, p=0.014), more likely to have diabetes mellitus (p=0.022), and anemia (p=0.042), and had significantly lower serum albumin (p=0.005), total cholesterol (p=0.024), and iron (p=0.004) levels, higher glucose (p=0.002) and C-reactive protein (p lt 0.001) levels, and lower dialysis adequacies (p=0.040) than the patients without PAD. Multivariate analysis showed higher C-reactive protein level (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.06; p=0.030), vascular access by Hickman catheter (OR, 4.66; 95% CI, 1.03-21.0; p=0.045), and symptoms of PAD (OR, 5.20; 95% CI, 2.60-10.4; p lt 0.001) as independent factors associated with PAD in hemodialysis patients.ConclusionThe prevalence of PAD was high among patients with end-stage renal disease on hemodialysis. Symptoms of PAD, higher C-reactive protein levels, and Hickman vascular access were independent predictors of PAD in patients on hemodialysis.
PB  - BMC, LONDON
T2  - BMC Nephrology
T1  - Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study
VL  - 20
DO  - 10.1186/s12882-019-1468-x
ER  - 

@article{
author = "Ašćerić, Radislav and Dimković, Nada and Trajković, Goran Z. and Ristić, Biljana S. and Janković, Aleksandar N. and Đurić, Petar and Ilijevski, Nenad S.",
year = "2019",
abstract = "BackgroundPeripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD and its risk factors in patients on hemodialysis.MethodsThis cross-sectional study included 156 hemodialysis patients. Comorbidities and laboratory parameters were analyzed. Following clinical examinations, the ankle-brachial index was measured in all patients. PAD was diagnosed based on the clinical findings, ankle-brachial index  lt 0.9, and PAD symptoms.ResultsPAD was present in 55 of 156 (35.3%; 95% CI, 27.7-42.8%) patients. The patients with PAD were significantly older (6710years vs. 62 +/- 11years, p=0.014), more likely to have diabetes mellitus (p=0.022), and anemia (p=0.042), and had significantly lower serum albumin (p=0.005), total cholesterol (p=0.024), and iron (p=0.004) levels, higher glucose (p=0.002) and C-reactive protein (p lt 0.001) levels, and lower dialysis adequacies (p=0.040) than the patients without PAD. Multivariate analysis showed higher C-reactive protein level (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.06; p=0.030), vascular access by Hickman catheter (OR, 4.66; 95% CI, 1.03-21.0; p=0.045), and symptoms of PAD (OR, 5.20; 95% CI, 2.60-10.4; p lt 0.001) as independent factors associated with PAD in hemodialysis patients.ConclusionThe prevalence of PAD was high among patients with end-stage renal disease on hemodialysis. Symptoms of PAD, higher C-reactive protein levels, and Hickman vascular access were independent predictors of PAD in patients on hemodialysis.",
publisher = "BMC, LONDON",
journal = "BMC Nephrology",
title = "Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study",
volume = "20",
doi = "10.1186/s12882-019-1468-x"
}

Ašćerić, R., Dimković, N., Trajković, G. Z., Ristić, B. S., Janković, A. N., Đurić, P.,& Ilijevski, N. S.. (2019). Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study. in BMC Nephrology
BMC, LONDON., 20.
https://doi.org/10.1186/s12882-019-1468-x

Ašćerić R, Dimković N, Trajković GZ, Ristić BS, Janković AN, Đurić P, Ilijevski NS. Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study. in BMC Nephrology. 2019;20.
doi:10.1186/s12882-019-1468-x .

Ašćerić, Radislav, Dimković, Nada, Trajković, Goran Z., Ristić, Biljana S., Janković, Aleksandar N., Đurić, Petar, Ilijevski, Nenad S., "Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study" in BMC Nephrology, 20 (2019),
https://doi.org/10.1186/s12882-019-1468-x . .

TY  - JOUR
AU  - Kuzmanović-Pfićer, Jovana
AU  - Dodić, Slobodan
AU  - Lazić, Vojkan
AU  - Trajković, Goran Z.
AU  - Milić, Nataša
AU  - Miličić, Biljana
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2197
AB  - Background Psychological discomfort, physical disability and functional limitations of the orofacial system have a major impact on everyday life of patients with temporomandibular disorders (TMDs). In this study we sought to determine short and long term effects of stabilization splint (SS) in treatment of TMDs, and to identify factors influencing its efficacy. Methods MEDLINE, Web of Science and EMBASE were searched for randomized controlled trials (RCTs) comparing SS to: non-occluding splint, occlusal oral appliances, physiotherapy, behavioral therapy, counseling and no treatment. Random effects method was used to summarize outcomes. The effect estimates were expressed as odds ratio (OR) or standardized mean difference (SMD) with 95% confidence interval. Subgroup analyses were carried out according to the use of Research Diagnostic Criteria (RDC/TMD) and TMDs origin. Strength of evidence was assessed by GRADE. Meta-regression was applied. Results Thirty three eligible RCTs were included in meta-analysis. In short term, SS presented positive overall effect on pain reduction (OR 2.08; p = 0.01) and pain intensity (SMD -0.33; p = 0.02). Subgroup analyses confirmed SS effect in studies used RDC/TMD and revealed its effect in patients with TMDs of muscular origin. Important decrease of muscle tenderness (OR 1.97; p = 0.03) and improvement of mouth opening (SMD -0.30; p = 0.04) were found. SS in comparison to oral appliances showed no difference (OR 0.74; p = 0.24). Meta-regression identified continuous use of SS during the day as a factor influencing efficacy (p = 0.01). Long term results showed no difference in observed outcomes between groups. Low quality of evidence was found for primary outcomes. Conclusion SS presented short term benefit for patients with TMDs. In long term follow up, the effect is equalized with other therapeutic modalities. Further studies based on appropriate use of standardized criteria for patient recruitment and outcomes under assessment are needed to better define SS effect persistence in long term.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Occlusal stabilization splint for patients with temporomandibular disorders: Meta-analysis of short and long term effects
VL  - 12
IS  - 2
DO  - 10.1371/journal.pone.0171296
ER  - 

@article{
author = "Kuzmanović-Pfićer, Jovana and Dodić, Slobodan and Lazić, Vojkan and Trajković, Goran Z. and Milić, Nataša and Miličić, Biljana",
year = "2017",
abstract = "Background Psychological discomfort, physical disability and functional limitations of the orofacial system have a major impact on everyday life of patients with temporomandibular disorders (TMDs). In this study we sought to determine short and long term effects of stabilization splint (SS) in treatment of TMDs, and to identify factors influencing its efficacy. Methods MEDLINE, Web of Science and EMBASE were searched for randomized controlled trials (RCTs) comparing SS to: non-occluding splint, occlusal oral appliances, physiotherapy, behavioral therapy, counseling and no treatment. Random effects method was used to summarize outcomes. The effect estimates were expressed as odds ratio (OR) or standardized mean difference (SMD) with 95% confidence interval. Subgroup analyses were carried out according to the use of Research Diagnostic Criteria (RDC/TMD) and TMDs origin. Strength of evidence was assessed by GRADE. Meta-regression was applied. Results Thirty three eligible RCTs were included in meta-analysis. In short term, SS presented positive overall effect on pain reduction (OR 2.08; p = 0.01) and pain intensity (SMD -0.33; p = 0.02). Subgroup analyses confirmed SS effect in studies used RDC/TMD and revealed its effect in patients with TMDs of muscular origin. Important decrease of muscle tenderness (OR 1.97; p = 0.03) and improvement of mouth opening (SMD -0.30; p = 0.04) were found. SS in comparison to oral appliances showed no difference (OR 0.74; p = 0.24). Meta-regression identified continuous use of SS during the day as a factor influencing efficacy (p = 0.01). Long term results showed no difference in observed outcomes between groups. Low quality of evidence was found for primary outcomes. Conclusion SS presented short term benefit for patients with TMDs. In long term follow up, the effect is equalized with other therapeutic modalities. Further studies based on appropriate use of standardized criteria for patient recruitment and outcomes under assessment are needed to better define SS effect persistence in long term.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Occlusal stabilization splint for patients with temporomandibular disorders: Meta-analysis of short and long term effects",
volume = "12",
number = "2",
doi = "10.1371/journal.pone.0171296"
}

Kuzmanović-Pfićer, J., Dodić, S., Lazić, V., Trajković, G. Z., Milić, N.,& Miličić, B.. (2017). Occlusal stabilization splint for patients with temporomandibular disorders: Meta-analysis of short and long term effects. in PLoS One
Public Library Science, San Francisco., 12(2).
https://doi.org/10.1371/journal.pone.0171296

Kuzmanović-Pfićer J, Dodić S, Lazić V, Trajković GZ, Milić N, Miličić B. Occlusal stabilization splint for patients with temporomandibular disorders: Meta-analysis of short and long term effects. in PLoS One. 2017;12(2).
doi:10.1371/journal.pone.0171296 .

Kuzmanović-Pfićer, Jovana, Dodić, Slobodan, Lazić, Vojkan, Trajković, Goran Z., Milić, Nataša, Miličić, Biljana, "Occlusal stabilization splint for patients with temporomandibular disorders: Meta-analysis of short and long term effects" in PLoS One, 12, no. 2 (2017),
https://doi.org/10.1371/journal.pone.0171296 . .