Babić, Marko

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  • Babić, Marko (9)
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Author's Bibliography

Growth hormone positive effects on craniofacial complex in Turner syndrome

Juloski, Jovana; Dumancić, Jelena; Šćepan, Ivana; Lauc, Tomislav; Milašin, Jelena; Kaić, Zvonimir; Dumić, Miroslav; Babić, Marko

(Pergamon-Elsevier Science Ltd, Oxford, 2016)

TY  - JOUR
AU  - Juloski, Jovana
AU  - Dumancić, Jelena
AU  - Šćepan, Ivana
AU  - Lauc, Tomislav
AU  - Milašin, Jelena
AU  - Kaić, Zvonimir
AU  - Dumić, Miroslav
AU  - Babić, Marko
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2099
AB  - Objective: Turner syndrome occurs in phenotypic females with complete or partial absence of X chromosome. The leading symptom is short stature, while numerous but mild stigmata manifest in the craniofacial region. These patients are commonly treated with growth hormone to improve their final height. The aim of this study was to assess the influence of long-term growth hormone therapy on craniofacial morphology in Turner syndrome patients. Design: In this cross-sectional study cephalometric analysis was performed on 13 lateral cephalograms of patients with 45,X karyotype and the average age of 17.3 years, who have received growth hormone for at least two years. The control group consisted of 13 Turner syndrome patients naive to growth hormone treatment, matched to study group by age and karyotype. Sixteen linear and angular measurements were obtained from standard lateral cephalograms. Standard deviation scores were calculated in order to evaluate influence of growth hormone therapy on craniofacial components. Results: In Turner syndrome patients treated with growth hormone most of linear measurements were significantly larger compared to untreated patients. Growth hormone therapy mainly influenced posterior face height, mandibular ramus height, total mandibular length, anterior face height and maxillary length. While the increase in linear measurements was evident, angular measurements and facial height ratio did not show statistically significant difference. Acromegalic features were not found. Conclusions: Long-term growth hormone therapy has positive influence on craniofacial development in Turner syndrome patients, with the greatest impact on posterior facial height and mandibular ramus. However, it could not compensate X chromosome deficiency and normalize craniofacial features.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - Growth hormone positive effects on craniofacial complex in Turner syndrome
VL  - 71
SP  - 10
EP  - 15
DO  - 10.1016/j.archoralbio.2016.06.012
ER  - 
@article{
author = "Juloski, Jovana and Dumancić, Jelena and Šćepan, Ivana and Lauc, Tomislav and Milašin, Jelena and Kaić, Zvonimir and Dumić, Miroslav and Babić, Marko",
year = "2016",
abstract = "Objective: Turner syndrome occurs in phenotypic females with complete or partial absence of X chromosome. The leading symptom is short stature, while numerous but mild stigmata manifest in the craniofacial region. These patients are commonly treated with growth hormone to improve their final height. The aim of this study was to assess the influence of long-term growth hormone therapy on craniofacial morphology in Turner syndrome patients. Design: In this cross-sectional study cephalometric analysis was performed on 13 lateral cephalograms of patients with 45,X karyotype and the average age of 17.3 years, who have received growth hormone for at least two years. The control group consisted of 13 Turner syndrome patients naive to growth hormone treatment, matched to study group by age and karyotype. Sixteen linear and angular measurements were obtained from standard lateral cephalograms. Standard deviation scores were calculated in order to evaluate influence of growth hormone therapy on craniofacial components. Results: In Turner syndrome patients treated with growth hormone most of linear measurements were significantly larger compared to untreated patients. Growth hormone therapy mainly influenced posterior face height, mandibular ramus height, total mandibular length, anterior face height and maxillary length. While the increase in linear measurements was evident, angular measurements and facial height ratio did not show statistically significant difference. Acromegalic features were not found. Conclusions: Long-term growth hormone therapy has positive influence on craniofacial development in Turner syndrome patients, with the greatest impact on posterior facial height and mandibular ramus. However, it could not compensate X chromosome deficiency and normalize craniofacial features.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "Growth hormone positive effects on craniofacial complex in Turner syndrome",
volume = "71",
pages = "10-15",
doi = "10.1016/j.archoralbio.2016.06.012"
}
Juloski, J., Dumancić, J., Šćepan, I., Lauc, T., Milašin, J., Kaić, Z., Dumić, M.,& Babić, M.. (2016). Growth hormone positive effects on craniofacial complex in Turner syndrome. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 71, 10-15.
https://doi.org/10.1016/j.archoralbio.2016.06.012
Juloski J, Dumancić J, Šćepan I, Lauc T, Milašin J, Kaić Z, Dumić M, Babić M. Growth hormone positive effects on craniofacial complex in Turner syndrome. in Archives of Oral Biology. 2016;71:10-15.
doi:10.1016/j.archoralbio.2016.06.012 .
Juloski, Jovana, Dumancić, Jelena, Šćepan, Ivana, Lauc, Tomislav, Milašin, Jelena, Kaić, Zvonimir, Dumić, Miroslav, Babić, Marko, "Growth hormone positive effects on craniofacial complex in Turner syndrome" in Archives of Oral Biology, 71 (2016):10-15,
https://doi.org/10.1016/j.archoralbio.2016.06.012 . .
16
12
13

Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone

Juloski, Jovana; Glišić, Branislav; Šćepan, Ivana; Milašin, Jelena; Mitrović, Katarina; Babić, Marko

(Springer Heidelberg, Heidelberg, 2013)

TY  - JOUR
AU  - Juloski, Jovana
AU  - Glišić, Branislav
AU  - Šćepan, Ivana
AU  - Milašin, Jelena
AU  - Mitrović, Katarina
AU  - Babić, Marko
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1828
AB  - The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone
VL  - 17
IS  - 6
SP  - 1563
EP  - 1571
DO  - 10.1007/s00784-012-0844-8
ER  - 
@article{
author = "Juloski, Jovana and Glišić, Branislav and Šćepan, Ivana and Milašin, Jelena and Mitrović, Katarina and Babić, Marko",
year = "2013",
abstract = "The present study assessed changes of craniofacial complex in Turner syndrome (TS) patients treated with growth hormone (GH) during development. The objective was to examine the growth rate and pattern of craniofacial structures and to establish effects of GH on craniofacial development. The study population consisted of 15 TS patients treated with GH aged 5-18.5 years (13.3 +/- 4.4) and corresponding control group of 45 females aged 6.8-18.7 (11.4 +/- 2.6). According to the stage of cervical vertebral maturation, subjects were categorized into pre-growth (5 TS and 15 controls) and growth (10 TS and 30 controls) subgroups. The cephalometric analysis comprised angular and linear variables, measured on lateral cephalometric radiographs. The mandibular corpus/anterior cranial base ratio increased significantly only in controls during development. In growth period, ramus/corpus ratio was significantly larger in TS group. SNA and SNB angles were significantly smaller in TS growth subgroup compared to corresponding controls. Among other variables, no statistically significant differences were revealed. In TS patients treated with GH, growth capacities of cranial base and maxilla are adequate which can be attributed to GH treatment. Shape of mandible is altered due to decreased growth of corpus and overdeveloped ramus. Both maxillary and mandibular retrognathism are becoming more expressed during development. Favorable influence of GH on craniofacial complex growth rate and altered growth pattern revealed in this study should be considered while planning both orthodontic treatment and retention.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone",
volume = "17",
number = "6",
pages = "1563-1571",
doi = "10.1007/s00784-012-0844-8"
}
Juloski, J., Glišić, B., Šćepan, I., Milašin, J., Mitrović, K.,& Babić, M.. (2013). Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 17(6), 1563-1571.
https://doi.org/10.1007/s00784-012-0844-8
Juloski J, Glišić B, Šćepan I, Milašin J, Mitrović K, Babić M. Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone. in Clinical Oral Investigations. 2013;17(6):1563-1571.
doi:10.1007/s00784-012-0844-8 .
Juloski, Jovana, Glišić, Branislav, Šćepan, Ivana, Milašin, Jelena, Mitrović, Katarina, Babić, Marko, "Ontogenetic changes of craniofacial complex in Turner syndrome patients treated with growth hormone" in Clinical Oral Investigations, 17, no. 6 (2013):1563-1571,
https://doi.org/10.1007/s00784-012-0844-8 . .
9
9
9

Abnormalities in enamel structure and their association with systemic diseases and syndromes

Jeremić, Marko; Marković, Dejan; Vuković, Ana; Babić, Marko; Jokanović, Vukoman

(Srpsko lekarsko društvo - Stomatološka sekcija, Beograd, 2011)

TY  - JOUR
AU  - Jeremić, Marko
AU  - Marković, Dejan
AU  - Vuković, Ana
AU  - Babić, Marko
AU  - Jokanović, Vukoman
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1640
AB  - Etiology of abnormalities in tooth structure has been subject of numerous studies but still has not been fully understood. Heredity is an established etiological factor for many types of structural anomalies of the teeth. Factors that cause changes in enamel structure may be genetic, immunologic and teratogenic or systemic diseases. Genetic changes may include individual genes, micro deletions or chromosomal defects. Systemic diseases can be associated with anomalies of tooth structure and diversity of clinical picture requires a multidisciplinary approach to the therapy. Amelogenesis imperfecta (AI) represents a large group of structural abnormalities of the teeth. AI can exist independently or as a part of large number of syndromes and systemic diseases. Knowledge of clinical presentation, etiology, pathogenesis of structural anomalies of the teeth and their association with certain systemic diseases is of great importance to everyday dental practice in terms of prevention, prognosis and therapy. Also, it is necessary to expand basic knowledge of pediatricians in regards to the clinical picture of anomalies in tooth structure and their possible association with a wide range of systemic diseases and syndromes, in order to provide comprehensive clinical treatment. Therefore, the aim of this study was to present etiopathogenesis and classification and to describe the most important abnormalities of enamel structure and their association with systemic diseases and syndromes.
AB  - Etiologija nastanka strukturnih anomalija zuba predmet je mnogih studija, ali još nije potpuno razjašnjena. Nasleđe je dokazani etiološki faktor za mnoge tipove strukturnih anomalija zuba. Faktori koji izazivaju promene u gleđi mogu biti genetske i imunološke prirode, posledica teratogenih faktora i sistemskih bolesti. Genske promene mogu obuhvatati pojedinačne gene, mikrodelecije ili oštećenja samog hromozoma. Veliki broj različitih sistemskih oboljenja koja se dovode u vezu sa strukturnim anomalijama zuba i raznolikost njihove kliničke slike zahteva multidisciplinaran pristup u lečenju. Amelogenesis imperfecta je velika grupa strukturnih anomalija zuba. Može biti samostalno oboljenje ili u sklopu velikog broja sindroma i sistemskih oboljenja. Poznavanje kliničke slike, porekla i patogeneze strukturnih anomalija zuba, te njihove povezanosti s pojedinim sistemskim oboljenjima, od velikog je značaja za svakodnevnu stomatološku praksu s aspekta prevencije, prognostike i terapije. Takođe, potrebno je proširiti osnovno znanje pedijatara u pogledu kliničke slike strukturnih anomalija zuba i njihove moguće veze sa širokim spektrom sistemskih oboljenja i sindroma, kako bi se obezbedio sveobuhvatan klinički tretman. Cilj ovog rada bio je da se predstave etiopatogeneza, klasifikacija i osnovni poremećaji strukture gleđi, odnosno njihova povezanost sa sistematskim oboljenjima i sindromima.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Abnormalities in enamel structure and their association with systemic diseases and syndromes
T1  - Poremećaji strukture gleđi i njihova veza sa sistemskim oboljenjima i sindromima
VL  - 58
IS  - 4
SP  - 229
EP  - 238
DO  - 10.2298/SGS1104229J
ER  - 
@article{
author = "Jeremić, Marko and Marković, Dejan and Vuković, Ana and Babić, Marko and Jokanović, Vukoman",
year = "2011",
abstract = "Etiology of abnormalities in tooth structure has been subject of numerous studies but still has not been fully understood. Heredity is an established etiological factor for many types of structural anomalies of the teeth. Factors that cause changes in enamel structure may be genetic, immunologic and teratogenic or systemic diseases. Genetic changes may include individual genes, micro deletions or chromosomal defects. Systemic diseases can be associated with anomalies of tooth structure and diversity of clinical picture requires a multidisciplinary approach to the therapy. Amelogenesis imperfecta (AI) represents a large group of structural abnormalities of the teeth. AI can exist independently or as a part of large number of syndromes and systemic diseases. Knowledge of clinical presentation, etiology, pathogenesis of structural anomalies of the teeth and their association with certain systemic diseases is of great importance to everyday dental practice in terms of prevention, prognosis and therapy. Also, it is necessary to expand basic knowledge of pediatricians in regards to the clinical picture of anomalies in tooth structure and their possible association with a wide range of systemic diseases and syndromes, in order to provide comprehensive clinical treatment. Therefore, the aim of this study was to present etiopathogenesis and classification and to describe the most important abnormalities of enamel structure and their association with systemic diseases and syndromes., Etiologija nastanka strukturnih anomalija zuba predmet je mnogih studija, ali još nije potpuno razjašnjena. Nasleđe je dokazani etiološki faktor za mnoge tipove strukturnih anomalija zuba. Faktori koji izazivaju promene u gleđi mogu biti genetske i imunološke prirode, posledica teratogenih faktora i sistemskih bolesti. Genske promene mogu obuhvatati pojedinačne gene, mikrodelecije ili oštećenja samog hromozoma. Veliki broj različitih sistemskih oboljenja koja se dovode u vezu sa strukturnim anomalijama zuba i raznolikost njihove kliničke slike zahteva multidisciplinaran pristup u lečenju. Amelogenesis imperfecta je velika grupa strukturnih anomalija zuba. Može biti samostalno oboljenje ili u sklopu velikog broja sindroma i sistemskih oboljenja. Poznavanje kliničke slike, porekla i patogeneze strukturnih anomalija zuba, te njihove povezanosti s pojedinim sistemskim oboljenjima, od velikog je značaja za svakodnevnu stomatološku praksu s aspekta prevencije, prognostike i terapije. Takođe, potrebno je proširiti osnovno znanje pedijatara u pogledu kliničke slike strukturnih anomalija zuba i njihove moguće veze sa širokim spektrom sistemskih oboljenja i sindroma, kako bi se obezbedio sveobuhvatan klinički tretman. Cilj ovog rada bio je da se predstave etiopatogeneza, klasifikacija i osnovni poremećaji strukture gleđi, odnosno njihova povezanost sa sistematskim oboljenjima i sindromima.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Abnormalities in enamel structure and their association with systemic diseases and syndromes, Poremećaji strukture gleđi i njihova veza sa sistemskim oboljenjima i sindromima",
volume = "58",
number = "4",
pages = "229-238",
doi = "10.2298/SGS1104229J"
}
Jeremić, M., Marković, D., Vuković, A., Babić, M.,& Jokanović, V.. (2011). Abnormalities in enamel structure and their association with systemic diseases and syndromes. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 58(4), 229-238.
https://doi.org/10.2298/SGS1104229J
Jeremić M, Marković D, Vuković A, Babić M, Jokanović V. Abnormalities in enamel structure and their association with systemic diseases and syndromes. in Stomatološki glasnik Srbije. 2011;58(4):229-238.
doi:10.2298/SGS1104229J .
Jeremić, Marko, Marković, Dejan, Vuković, Ana, Babić, Marko, Jokanović, Vukoman, "Abnormalities in enamel structure and their association with systemic diseases and syndromes" in Stomatološki glasnik Srbije, 58, no. 4 (2011):229-238,
https://doi.org/10.2298/SGS1104229J . .
1

Cancer genes alterations and HPV infection in oral squamous cell carcinoma

Popović, Branka; Jekić, Biljana; Novaković, Ivana; Luković, Ljiljana; Konstantinović, Vitomir; Babić, Marko; Milašin, Jelena

(Churchill Livingstone, Edinburgh, 2010)

TY  - JOUR
AU  - Popović, Branka
AU  - Jekić, Biljana
AU  - Novaković, Ivana
AU  - Luković, Ljiljana
AU  - Konstantinović, Vitomir
AU  - Babić, Marko
AU  - Milašin, Jelena
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1564
AB  - The aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analysed for erbB2 and c-myc amplification by dPCR, H-ras and p53 point mutations by PCR/SSCP. HPV was detected via amplification of its El and E6 genes. c-erbB2 was altered in 45%, c-myc in 35%, H-ras in 22% and p53 in 60% of samples. HPV was detected in 10% of cases. The frequency of p53 gene mutations showed a statistically significant association with tumour stage. Patients with c-erbB2 and H-ras alterations had lower survival than patients without these alterations. The number of detected genetic changes was remarkable but statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - Cancer genes alterations and HPV infection in oral squamous cell carcinoma
VL  - 39
IS  - 9
SP  - 909
EP  - 915
DO  - 10.1016/j.ijom.2010.05.007
ER  - 
@article{
author = "Popović, Branka and Jekić, Biljana and Novaković, Ivana and Luković, Ljiljana and Konstantinović, Vitomir and Babić, Marko and Milašin, Jelena",
year = "2010",
abstract = "The aim of this study was to gain a better understanding of cancer genes contributing to oral squamous cell (OSCC) development and progression and correlate genetic changes to clinical parameters. Human papilloma virus (HPV) 16 detection is also included in the study. 60 samples of OSCC were analysed for erbB2 and c-myc amplification by dPCR, H-ras and p53 point mutations by PCR/SSCP. HPV was detected via amplification of its El and E6 genes. c-erbB2 was altered in 45%, c-myc in 35%, H-ras in 22% and p53 in 60% of samples. HPV was detected in 10% of cases. The frequency of p53 gene mutations showed a statistically significant association with tumour stage. Patients with c-erbB2 and H-ras alterations had lower survival than patients without these alterations. The number of detected genetic changes was remarkable but statistical association with tumour natural history was poor, indicating high clonal heterogeneity and multiple pathways of carcinogenesis.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "Cancer genes alterations and HPV infection in oral squamous cell carcinoma",
volume = "39",
number = "9",
pages = "909-915",
doi = "10.1016/j.ijom.2010.05.007"
}
Popović, B., Jekić, B., Novaković, I., Luković, L., Konstantinović, V., Babić, M.,& Milašin, J.. (2010). Cancer genes alterations and HPV infection in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 39(9), 909-915.
https://doi.org/10.1016/j.ijom.2010.05.007
Popović B, Jekić B, Novaković I, Luković L, Konstantinović V, Babić M, Milašin J. Cancer genes alterations and HPV infection in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery. 2010;39(9):909-915.
doi:10.1016/j.ijom.2010.05.007 .
Popović, Branka, Jekić, Biljana, Novaković, Ivana, Luković, Ljiljana, Konstantinović, Vitomir, Babić, Marko, Milašin, Jelena, "Cancer genes alterations and HPV infection in oral squamous cell carcinoma" in International Journal of Oral & Maxillofacial Surgery, 39, no. 9 (2010):909-915,
https://doi.org/10.1016/j.ijom.2010.05.007 . .
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25

Craniofacial complex specificities in five men with sex reversal syndrome

Šćepan, Ivana; Glišić, Branislav; Marković, Evgenija; Babić, Marko

(Springer Heidelberg, Heidelberg, 2008)

TY  - JOUR
AU  - Šćepan, Ivana
AU  - Glišić, Branislav
AU  - Marković, Evgenija
AU  - Babić, Marko
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1388
AB  - In order to clarify the role of sex chromosome constitution in craniofacial growth control, we compared craniofacial morphology of men with sex reversal syndrome (46, XX) with the morphology of normal men, Klinefelter's syndrome and normal women, using cephalometric measurements. Due to physical resemblance between men with 46, XX karyotype and men with 47, XXY karyotype, cephalometric analysis comprised parametres which had already been found to be specific for Klinefelter's syndrome, i.e. cranial base length and flexion, maxillary and mandibular base length, jaw position in relation to cranial base and sagittal jaw relationship. Linear measurements showed reduction of about 10% in maxillary base length in 46, XX men in relation to normal men. Mandibular base in men with sex reversal syndrome was also shortened for about 10% in relation to both normal men and Klinefelter's syndrome. Cranial base flexion in men with Klinefelter's syndrome and in men with sex reversal syndrome showed similarity. The basal angle was found to be more acute, for about 4, in comparison to individuals with normal karyotype. Unlike in men with Klinefelter's syndrome, mandibular and maxillary prognathism were not registered in men with sex reversal syndrome.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Craniofacial complex specificities in five men with sex reversal syndrome
VL  - 12
IS  - 3
SP  - 265
EP  - 269
DO  - 10.1007/s00784-008-0187-7
ER  - 
@article{
author = "Šćepan, Ivana and Glišić, Branislav and Marković, Evgenija and Babić, Marko",
year = "2008",
abstract = "In order to clarify the role of sex chromosome constitution in craniofacial growth control, we compared craniofacial morphology of men with sex reversal syndrome (46, XX) with the morphology of normal men, Klinefelter's syndrome and normal women, using cephalometric measurements. Due to physical resemblance between men with 46, XX karyotype and men with 47, XXY karyotype, cephalometric analysis comprised parametres which had already been found to be specific for Klinefelter's syndrome, i.e. cranial base length and flexion, maxillary and mandibular base length, jaw position in relation to cranial base and sagittal jaw relationship. Linear measurements showed reduction of about 10% in maxillary base length in 46, XX men in relation to normal men. Mandibular base in men with sex reversal syndrome was also shortened for about 10% in relation to both normal men and Klinefelter's syndrome. Cranial base flexion in men with Klinefelter's syndrome and in men with sex reversal syndrome showed similarity. The basal angle was found to be more acute, for about 4, in comparison to individuals with normal karyotype. Unlike in men with Klinefelter's syndrome, mandibular and maxillary prognathism were not registered in men with sex reversal syndrome.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Craniofacial complex specificities in five men with sex reversal syndrome",
volume = "12",
number = "3",
pages = "265-269",
doi = "10.1007/s00784-008-0187-7"
}
Šćepan, I., Glišić, B., Marković, E.,& Babić, M.. (2008). Craniofacial complex specificities in five men with sex reversal syndrome. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 12(3), 265-269.
https://doi.org/10.1007/s00784-008-0187-7
Šćepan I, Glišić B, Marković E, Babić M. Craniofacial complex specificities in five men with sex reversal syndrome. in Clinical Oral Investigations. 2008;12(3):265-269.
doi:10.1007/s00784-008-0187-7 .
Šćepan, Ivana, Glišić, Branislav, Marković, Evgenija, Babić, Marko, "Craniofacial complex specificities in five men with sex reversal syndrome" in Clinical Oral Investigations, 12, no. 3 (2008):265-269,
https://doi.org/10.1007/s00784-008-0187-7 . .
1
1
2

Craniofacial morphology in males with 46,XX chromosomal constitution

Šćepan, Ivana; Glišić, Branislav; Babić, Marko; Nikolić, Zorana; Đorđević, Dušan

(Srpsko lekarsko društvo - Stomatološka sekcija, Beograd, 2003)

TY  - JOUR
AU  - Šćepan, Ivana
AU  - Glišić, Branislav
AU  - Babić, Marko
AU  - Nikolić, Zorana
AU  - Đorđević, Dušan
PY  - 2003
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1175
AB  - The aim of this investigation was to assess the craniofacial morphology of five male individuals with 46,XX chromosomal constitution, and to compare them with normal male individuals (46,XY) and normal female participates (46,XX). The investigation was carried out on the lateral cephalomestic radiographs of five male individuals with sex reverse syndrome (46,XX chromosomal constitution), 62 normal female (46,XX) and 31 normal male (46,XY chromosomal constitution) participants. The following angular variables were measured: SNA, SNB, ANB, SN/SpP, SN/MP and SpP/MP. For each variable the mean value and standard deviation were calculated. The Student t-test was used to compare the result obtained between the group of patients with sex reverse syndrome and group of normal male, as well as of normal female participants. The male individuals with 46, XX chromosomal constitution showed slight bimaxillary retrognathism, and class III sagittal jaw relationship. Due to decreased inclination of the upper jaw to the anterior cranial base, the angle of vertical jaw relationship slightly increased in the group of patients with sex reverse syndrome, compared to normal male and female participants.
AB  - Cilj ovog istraživanja bio je da se ispita kraniofacijalna morfologija muškaraca sa 46,XX hromozomskom konstitucijom i uporedi sa morfologijom normalnih žena (46,XX) i muškaraca (46,XY). Istraživanje je sprovedeno na profilnim kefalometrijskim snimcima tri grupe ispitanika. Prvu grupu sačinjavalo je pet muškaraca sa hromozomskom konstitucijom 46,XX. Drugu grupu činila su 62 kefalometrijska snimka normalnih žena sa hromozomskom konstitucijom 46,XX, a treću 31 snimak normalnih muškaraca sa hromozomskom konstitucijom 46,XY. Na kefalometrijskim snimcima su mereni sledeći angularni parametri: SNA, SNB, ANB, SN/SpP, SN/MP i SpP/MP. Za sve analizirane parametre izračunata je prosečna vrednost i standardna devijacija, a t-testom je ispitivano postojanje statistički značajnih razlika između tri analizirane grupe ispitanika. Istraživanjem je utvrđeno da se 46,XX muškarci odlikuju blagim bimaksilarnim retrognatizmom i skeletnim sagitalnim odnosom III klase. Blago povećanje vertikalnog međuviličnog ugla kod 46,XX muškaraca posledica je manje inklinacije gornje vilice u odnosu na osnovnu ravan prednje kranijalne baze.
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - Craniofacial morphology in males with 46,XX chromosomal constitution
T1  - Kraniofacijalna morfologija muškaraca sa 46,XX hromozomskom konstitucijom
VL  - 50
IS  - 3
SP  - 120
EP  - 123
DO  - 10.2298/SGS0303120I
ER  - 
@article{
author = "Šćepan, Ivana and Glišić, Branislav and Babić, Marko and Nikolić, Zorana and Đorđević, Dušan",
year = "2003",
abstract = "The aim of this investigation was to assess the craniofacial morphology of five male individuals with 46,XX chromosomal constitution, and to compare them with normal male individuals (46,XY) and normal female participates (46,XX). The investigation was carried out on the lateral cephalomestic radiographs of five male individuals with sex reverse syndrome (46,XX chromosomal constitution), 62 normal female (46,XX) and 31 normal male (46,XY chromosomal constitution) participants. The following angular variables were measured: SNA, SNB, ANB, SN/SpP, SN/MP and SpP/MP. For each variable the mean value and standard deviation were calculated. The Student t-test was used to compare the result obtained between the group of patients with sex reverse syndrome and group of normal male, as well as of normal female participants. The male individuals with 46, XX chromosomal constitution showed slight bimaxillary retrognathism, and class III sagittal jaw relationship. Due to decreased inclination of the upper jaw to the anterior cranial base, the angle of vertical jaw relationship slightly increased in the group of patients with sex reverse syndrome, compared to normal male and female participants., Cilj ovog istraživanja bio je da se ispita kraniofacijalna morfologija muškaraca sa 46,XX hromozomskom konstitucijom i uporedi sa morfologijom normalnih žena (46,XX) i muškaraca (46,XY). Istraživanje je sprovedeno na profilnim kefalometrijskim snimcima tri grupe ispitanika. Prvu grupu sačinjavalo je pet muškaraca sa hromozomskom konstitucijom 46,XX. Drugu grupu činila su 62 kefalometrijska snimka normalnih žena sa hromozomskom konstitucijom 46,XX, a treću 31 snimak normalnih muškaraca sa hromozomskom konstitucijom 46,XY. Na kefalometrijskim snimcima su mereni sledeći angularni parametri: SNA, SNB, ANB, SN/SpP, SN/MP i SpP/MP. Za sve analizirane parametre izračunata je prosečna vrednost i standardna devijacija, a t-testom je ispitivano postojanje statistički značajnih razlika između tri analizirane grupe ispitanika. Istraživanjem je utvrđeno da se 46,XX muškarci odlikuju blagim bimaksilarnim retrognatizmom i skeletnim sagitalnim odnosom III klase. Blago povećanje vertikalnog međuviličnog ugla kod 46,XX muškaraca posledica je manje inklinacije gornje vilice u odnosu na osnovnu ravan prednje kranijalne baze.",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "Craniofacial morphology in males with 46,XX chromosomal constitution, Kraniofacijalna morfologija muškaraca sa 46,XX hromozomskom konstitucijom",
volume = "50",
number = "3",
pages = "120-123",
doi = "10.2298/SGS0303120I"
}
Šćepan, I., Glišić, B., Babić, M., Nikolić, Z.,& Đorđević, D.. (2003). Craniofacial morphology in males with 46,XX chromosomal constitution. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 50(3), 120-123.
https://doi.org/10.2298/SGS0303120I
Šćepan I, Glišić B, Babić M, Nikolić Z, Đorđević D. Craniofacial morphology in males with 46,XX chromosomal constitution. in Stomatološki glasnik Srbije. 2003;50(3):120-123.
doi:10.2298/SGS0303120I .
Šćepan, Ivana, Glišić, Branislav, Babić, Marko, Nikolić, Zorana, Đorđević, Dušan, "Craniofacial morphology in males with 46,XX chromosomal constitution" in Stomatološki glasnik Srbije, 50, no. 3 (2003):120-123,
https://doi.org/10.2298/SGS0303120I . .

Mandibular growth pattern in Turner's syndrome

Babić, Marko; Glišić, Branislav; Šćepan, Ivana

(Oxford Univ Press, Oxford, 1997)

TY  - JOUR
AU  - Babić, Marko
AU  - Glišić, Branislav
AU  - Šćepan, Ivana
PY  - 1997
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1080
AB  - In a group of 15 women with 45,X chromosome constitution, mandibular growth type was investigated by using both linear and angular measurements. The sum of the saddle, articular and genial angle, lower genial angle and y-axis was significantly greater. In addition the posterio-anterior facial height ratio in women with Turner's syndrome was significantly smaller than in the controls (61 women with 46,XX chromosome constitution), indicating a tendency to backward and downward growth changes in the mandible, caused by an X chromosome deficiency.
PB  - Oxford Univ Press, Oxford
T2  - European Journal of Orthodontics
T1  - Mandibular growth pattern in Turner's syndrome
VL  - 19
IS  - 2
SP  - 161
EP  - 164
DO  - 10.1093/ejo/19.2.161
ER  - 
@article{
author = "Babić, Marko and Glišić, Branislav and Šćepan, Ivana",
year = "1997",
abstract = "In a group of 15 women with 45,X chromosome constitution, mandibular growth type was investigated by using both linear and angular measurements. The sum of the saddle, articular and genial angle, lower genial angle and y-axis was significantly greater. In addition the posterio-anterior facial height ratio in women with Turner's syndrome was significantly smaller than in the controls (61 women with 46,XX chromosome constitution), indicating a tendency to backward and downward growth changes in the mandible, caused by an X chromosome deficiency.",
publisher = "Oxford Univ Press, Oxford",
journal = "European Journal of Orthodontics",
title = "Mandibular growth pattern in Turner's syndrome",
volume = "19",
number = "2",
pages = "161-164",
doi = "10.1093/ejo/19.2.161"
}
Babić, M., Glišić, B.,& Šćepan, I.. (1997). Mandibular growth pattern in Turner's syndrome. in European Journal of Orthodontics
Oxford Univ Press, Oxford., 19(2), 161-164.
https://doi.org/10.1093/ejo/19.2.161
Babić M, Glišić B, Šćepan I. Mandibular growth pattern in Turner's syndrome. in European Journal of Orthodontics. 1997;19(2):161-164.
doi:10.1093/ejo/19.2.161 .
Babić, Marko, Glišić, Branislav, Šćepan, Ivana, "Mandibular growth pattern in Turner's syndrome" in European Journal of Orthodontics, 19, no. 2 (1997):161-164,
https://doi.org/10.1093/ejo/19.2.161 . .
10
8
10

Efekti aneuploidije X-hromozoma na morfogenezu kraniofacijalnog kompleksa i rast zuba

Babić, Marko

(Univerzitet u Beogradu, Stomatološki fakultet, 1993)

TY  - THES
AU  - Babić, Marko
PY  - 1993
UR  - https://plus.sr.cobiss.net/opac7/bib/18249231
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/289
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Efekti aneuploidije X-hromozoma na morfogenezu kraniofacijalnog kompleksa i rast zuba
UR  - https://hdl.handle.net/21.15107/rcub_smile_289
ER  - 
@phdthesis{
author = "Babić, Marko",
year = "1993",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Efekti aneuploidije X-hromozoma na morfogenezu kraniofacijalnog kompleksa i rast zuba",
url = "https://hdl.handle.net/21.15107/rcub_smile_289"
}
Babić, M.. (1993). Efekti aneuploidije X-hromozoma na morfogenezu kraniofacijalnog kompleksa i rast zuba. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_289
Babić M. Efekti aneuploidije X-hromozoma na morfogenezu kraniofacijalnog kompleksa i rast zuba. 1993;.
https://hdl.handle.net/21.15107/rcub_smile_289 .
Babić, Marko, "Efekti aneuploidije X-hromozoma na morfogenezu kraniofacijalnog kompleksa i rast zuba" (1993),
https://hdl.handle.net/21.15107/rcub_smile_289 .

A study of sagittal jaw relationships in patients with Klinefelter's syndrome

Šćepan, Ivana; Glišić, Branislav; Babić, Marko

(1991)

TY  - JOUR
AU  - Šćepan, Ivana
AU  - Glišić, Branislav
AU  - Babić, Marko
PY  - 1991
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1058
AB  - Lateral cephalometric radiographs were used to study sagittal jaw relationships in 22 cases with Klinefelter's syndrome. The following angles were measured: SNA, SNB and ANB. Depending on the size of SNA and SNB angles, all cases investigated were classified in the following groups: bimaxillary prognathism, bimaxillary orthognathism or retrognathism; maxillary prognathism combined with mandibular orthognathism; maxillary orthognathism combined with mandibular prognathism or retrognathism; maxillary retrognathism combined with mandibular prognathism, orthognathism, or retrognathism. The mean value of the ANB angle of the whole group was -0.20 degrees indicating the skeletal class III jaw relationship. Out of 22 cases investigated, 45.4% showed bimaxillary prognathism, and 27.3% had a combination of the maxillary orthognathism and mandibular prognathism. 27.3% of all cases investigated belonged to the remaining groups.
T2  - Bilten Udruzenja ortodonata Jugoslavije = Bulletin of Orthodontic Society of Yugoslavia
T1  - A study of sagittal jaw relationships in patients with Klinefelter's syndrome
T1  - Studija sagitalnih meduvilicnih odnosa kod osoba sa Klinefelterovim sindromom
VL  - 24
IS  - 2
SP  - 85
EP  - 88
UR  - https://hdl.handle.net/21.15107/rcub_smile_1058
ER  - 
@article{
author = "Šćepan, Ivana and Glišić, Branislav and Babić, Marko",
year = "1991",
abstract = "Lateral cephalometric radiographs were used to study sagittal jaw relationships in 22 cases with Klinefelter's syndrome. The following angles were measured: SNA, SNB and ANB. Depending on the size of SNA and SNB angles, all cases investigated were classified in the following groups: bimaxillary prognathism, bimaxillary orthognathism or retrognathism; maxillary prognathism combined with mandibular orthognathism; maxillary orthognathism combined with mandibular prognathism or retrognathism; maxillary retrognathism combined with mandibular prognathism, orthognathism, or retrognathism. The mean value of the ANB angle of the whole group was -0.20 degrees indicating the skeletal class III jaw relationship. Out of 22 cases investigated, 45.4% showed bimaxillary prognathism, and 27.3% had a combination of the maxillary orthognathism and mandibular prognathism. 27.3% of all cases investigated belonged to the remaining groups.",
journal = "Bilten Udruzenja ortodonata Jugoslavije = Bulletin of Orthodontic Society of Yugoslavia",
title = "A study of sagittal jaw relationships in patients with Klinefelter's syndrome, Studija sagitalnih meduvilicnih odnosa kod osoba sa Klinefelterovim sindromom",
volume = "24",
number = "2",
pages = "85-88",
url = "https://hdl.handle.net/21.15107/rcub_smile_1058"
}
Šćepan, I., Glišić, B.,& Babić, M.. (1991). A study of sagittal jaw relationships in patients with Klinefelter's syndrome. in Bilten Udruzenja ortodonata Jugoslavije = Bulletin of Orthodontic Society of Yugoslavia, 24(2), 85-88.
https://hdl.handle.net/21.15107/rcub_smile_1058
Šćepan I, Glišić B, Babić M. A study of sagittal jaw relationships in patients with Klinefelter's syndrome. in Bilten Udruzenja ortodonata Jugoslavije = Bulletin of Orthodontic Society of Yugoslavia. 1991;24(2):85-88.
https://hdl.handle.net/21.15107/rcub_smile_1058 .
Šćepan, Ivana, Glišić, Branislav, Babić, Marko, "A study of sagittal jaw relationships in patients with Klinefelter's syndrome" in Bilten Udruzenja ortodonata Jugoslavije = Bulletin of Orthodontic Society of Yugoslavia, 24, no. 2 (1991):85-88,
https://hdl.handle.net/21.15107/rcub_smile_1058 .
1