TY  - JOUR
AU  - Pavlović, Sanja
AU  - Stević, Zorica
AU  - Milovanović, Branislav
AU  - Miličić, Biljana
AU  - Rakocević-Stojanović, Vidosava
AU  - Lavrnić, Dragana
AU  - Apostolski, Slobodan
PY  - 2010
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1598
AB  - The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p  lt  0.01) and parasympathetic (p  lt  0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p  lt  0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p  lt  0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance.
PB  - Informa Healthcare, London
T2  - Amyotrophic Lateral Sclerosis
T1  - Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis
VL  - 11
IS  - 3
SP  - 272
EP  - 276
DO  - 10.3109/17482960903390855
ER  - 

@article{
author = "Pavlović, Sanja and Stević, Zorica and Milovanović, Branislav and Miličić, Biljana and Rakocević-Stojanović, Vidosava and Lavrnić, Dragana and Apostolski, Slobodan",
year = "2010",
abstract = "The aim of this study was to investigate autonomic cardiac control in patients with amyotrophic lateral sclerosis (ALS). Fifty-five patients with sporadic ALS (28 female and 27 male; average age 56.00 +/- 10.34 years) were compared to 30 healthy controls (17 female and 13 male; average age 42.87 +/- 11.91 years). Patients with previous history of cardiac disease, diabetes mellitus, and impaired respiratory function were excluded from the study. Cardiovascular autonomic tests according to Ewing, power spectrum analysis of RR variability (low- and high-frequency bands - LF and HF, LF/HF index), real-time beat-to-beat ECG signal monitoring with heart rate variability analysis and baroreflex function analysis were carried out in all patients. Time-domain parameters of heart rate variability (mean RR interval, SDNN, SDANN, SDNN index, rMSSD and pNN50%) were obtained from 24-h ECG monitoring. ALS patients had a significantly higher score of sympathetic (p  lt  0.01) and parasympathetic (p  lt  0.001) dysfunction, as well as of the overall score of autonomic dysfunction (p  lt  0.001). LF/HF index was significantly increased; baroreflex sensitivity and time-domain parameters of heart rate variability were highly significantly decreased in ALS patients (p  lt  0.001). Our results demonstrated impaired cardiac autonomic control in ALS with marked parasympathetic dysfunction and sympathetic predominance.",
publisher = "Informa Healthcare, London",
journal = "Amyotrophic Lateral Sclerosis",
title = "Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis",
volume = "11",
number = "3",
pages = "272-276",
doi = "10.3109/17482960903390855"
}

Pavlović, S., Stević, Z., Milovanović, B., Miličić, B., Rakocević-Stojanović, V., Lavrnić, D.,& Apostolski, S.. (2010). Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis. in Amyotrophic Lateral Sclerosis
Informa Healthcare, London., 11(3), 272-276.
https://doi.org/10.3109/17482960903390855

Pavlović S, Stević Z, Milovanović B, Miličić B, Rakocević-Stojanović V, Lavrnić D, Apostolski S. Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis. in Amyotrophic Lateral Sclerosis. 2010;11(3):272-276.
doi:10.3109/17482960903390855 .

Pavlović, Sanja, Stević, Zorica, Milovanović, Branislav, Miličić, Biljana, Rakocević-Stojanović, Vidosava, Lavrnić, Dragana, Apostolski, Slobodan, "Impairment of cardiac autonomic control in patients with amyotrophic lateral sclerosis" in Amyotrophic Lateral Sclerosis, 11, no. 3 (2010):272-276,
https://doi.org/10.3109/17482960903390855 . .

TY  - JOUR
AU  - Novaković, I.
AU  - Bojić, D
AU  - Todorović, S
AU  - Apostolski, Slobodan
AU  - Luković, L
AU  - Stefanović, D
AU  - Milašin, Jelena
PY  - 2005
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1251
AB  - Alterations in production of cytoskeletal protein dystrophin caused by in-frame gene, mutations lead to the Becker muscular dystrophy. In this study we analyzed genotype-phenotype correlation in a group of Becker musculaudystrophy patients with deletions affecting the proximal part of dystrophin gene, encompassing exons 3-13. Four patients with deletions affecting N terminal dystrophin domain had early onset and faster progression of the disease, while three patients with deletions in the proximal part, of dystrophin's rod domain had a more benign disease course. Our study suggests that proximal gene deletions in Becker muscular dystrophy have various phenotypic effects depending on the affected domain of protein dystrophin.
PB  - New York Acad Sciences, New York
T2  - Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus
T1  - Proximal dystrophin gene deletions and protein alterations in Becker muscular dystrophy
VL  - 1048
SP  - 406
EP  - 410
DO  - 10.1196/annals.1342.050
ER  - 

@article{
author = "Novaković, I. and Bojić, D and Todorović, S and Apostolski, Slobodan and Luković, L and Stefanović, D and Milašin, Jelena",
year = "2005",
abstract = "Alterations in production of cytoskeletal protein dystrophin caused by in-frame gene, mutations lead to the Becker muscular dystrophy. In this study we analyzed genotype-phenotype correlation in a group of Becker musculaudystrophy patients with deletions affecting the proximal part of dystrophin gene, encompassing exons 3-13. Four patients with deletions affecting N terminal dystrophin domain had early onset and faster progression of the disease, while three patients with deletions in the proximal part, of dystrophin's rod domain had a more benign disease course. Our study suggests that proximal gene deletions in Becker muscular dystrophy have various phenotypic effects depending on the affected domain of protein dystrophin.",
publisher = "New York Acad Sciences, New York",
journal = "Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus",
title = "Proximal dystrophin gene deletions and protein alterations in Becker muscular dystrophy",
volume = "1048",
pages = "406-410",
doi = "10.1196/annals.1342.050"
}

Novaković, I., Bojić, D., Todorović, S., Apostolski, S., Luković, L., Stefanović, D.,& Milašin, J.. (2005). Proximal dystrophin gene deletions and protein alterations in Becker muscular dystrophy. in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus
New York Acad Sciences, New York., 1048, 406-410.
https://doi.org/10.1196/annals.1342.050

Novaković I, Bojić D, Todorović S, Apostolski S, Luković L, Stefanović D, Milašin J. Proximal dystrophin gene deletions and protein alterations in Becker muscular dystrophy. in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus. 2005;1048:406-410.
doi:10.1196/annals.1342.050 .

Novaković, I., Bojić, D, Todorović, S, Apostolski, Slobodan, Luković, L, Stefanović, D, Milašin, Jelena, "Proximal dystrophin gene deletions and protein alterations in Becker muscular dystrophy" in Biophysics from Molecules to Brain: in Memory of Radoslav K. Andjus, 1048 (2005):406-410,
https://doi.org/10.1196/annals.1342.050 . .

TY  - CONF
AU  - Novaković, I.
AU  - Apostolski, Slobodan
AU  - Todorović, S
AU  - Luković, L
AU  - Bunjevački, Vera
AU  - Bojić, D
AU  - Mestroni, L
AU  - Milašin, Jelena
PY  - 2002
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1144
PB  - Nature Publishing Group, London
C3  - European Journal of Human Genetics
T1  - Cardiac disorders in BMD patients with distal gene deletions
VL  - 10
SP  - 257
EP  - 257
UR  - https://hdl.handle.net/21.15107/rcub_smile_1144
ER  - 

@conference{
author = "Novaković, I. and Apostolski, Slobodan and Todorović, S and Luković, L and Bunjevački, Vera and Bojić, D and Mestroni, L and Milašin, Jelena",
year = "2002",
publisher = "Nature Publishing Group, London",
journal = "European Journal of Human Genetics",
title = "Cardiac disorders in BMD patients with distal gene deletions",
volume = "10",
pages = "257-257",
url = "https://hdl.handle.net/21.15107/rcub_smile_1144"
}

Novaković, I., Apostolski, S., Todorović, S., Luković, L., Bunjevački, V., Bojić, D., Mestroni, L.,& Milašin, J.. (2002). Cardiac disorders in BMD patients with distal gene deletions. in European Journal of Human Genetics
Nature Publishing Group, London., 10, 257-257.
https://hdl.handle.net/21.15107/rcub_smile_1144

Novaković I, Apostolski S, Todorović S, Luković L, Bunjevački V, Bojić D, Mestroni L, Milašin J. Cardiac disorders in BMD patients with distal gene deletions. in European Journal of Human Genetics. 2002;10:257-257.
https://hdl.handle.net/21.15107/rcub_smile_1144 .

Novaković, I., Apostolski, Slobodan, Todorović, S, Luković, L, Bunjevački, Vera, Bojić, D, Mestroni, L, Milašin, Jelena, "Cardiac disorders in BMD patients with distal gene deletions" in European Journal of Human Genetics, 10 (2002):257-257,
https://hdl.handle.net/21.15107/rcub_smile_1144 .