TY  - JOUR
AU  - Dožić, Branko
AU  - Glumac, Sofija
AU  - Boricić, Novica
AU  - Dozić, Marko
AU  - Aničić, Boban
AU  - Boričić, Ivan
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2141
AB  - Purpose: Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. It is characterized by a high rate of recurrence, perineural invasion and development of distant metastases many years after removal of the primary tumor. Disorders of the induction of apoptosis and its cascade reactions where caspases are involved may be significant in the pathogenesis of this tumor. Methods: The immunohistochemical expression of caspase 9 and caspase 3 was analyzed by tissue microarray (TMA) in 50 cases of ACC in relation with different clinicopathological parameters (gender, age, localization, histological type and overall survival). Results: Caspase 9 was expressed in the cytoplasm and nuclei of ACC tumor cells with varying degrees of staining intensity (1+, 6%; 2+, 54%, 3+, 40%). Comparison of caspase 9 expression in tumor cells with clinicopathological parameters (gender, age, localization, histological type and overall survival) showed no statistically significant difference except that the expression was more pronounced in females. Caspase 3 was expressed in the cytoplasm of tumor cells with varying degrees of staining intensity (1+, 22%; 2+, 36%; 3+, 42%). No correlation between the expression of caspase 3 and clinicopathological parameters was noticed. Conclusions: The expression of caspases 9 and 3 in ACC of the salivary glands can contribute in the better characterization of molecules involved in apoptosis of tumor cells.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters
VL  - 21
IS  - 1
SP  - 152
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_smile_2141
ER  - 

@article{
author = "Dožić, Branko and Glumac, Sofija and Boricić, Novica and Dozić, Marko and Aničić, Boban and Boričić, Ivan",
year = "2016",
abstract = "Purpose: Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. It is characterized by a high rate of recurrence, perineural invasion and development of distant metastases many years after removal of the primary tumor. Disorders of the induction of apoptosis and its cascade reactions where caspases are involved may be significant in the pathogenesis of this tumor. Methods: The immunohistochemical expression of caspase 9 and caspase 3 was analyzed by tissue microarray (TMA) in 50 cases of ACC in relation with different clinicopathological parameters (gender, age, localization, histological type and overall survival). Results: Caspase 9 was expressed in the cytoplasm and nuclei of ACC tumor cells with varying degrees of staining intensity (1+, 6%; 2+, 54%, 3+, 40%). Comparison of caspase 9 expression in tumor cells with clinicopathological parameters (gender, age, localization, histological type and overall survival) showed no statistically significant difference except that the expression was more pronounced in females. Caspase 3 was expressed in the cytoplasm of tumor cells with varying degrees of staining intensity (1+, 22%; 2+, 36%; 3+, 42%). No correlation between the expression of caspase 3 and clinicopathological parameters was noticed. Conclusions: The expression of caspases 9 and 3 in ACC of the salivary glands can contribute in the better characterization of molecules involved in apoptosis of tumor cells.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters",
volume = "21",
number = "1",
pages = "152-160",
url = "https://hdl.handle.net/21.15107/rcub_smile_2141"
}

Dožić, B., Glumac, S., Boricić, N., Dozić, M., Aničić, B.,& Boričić, I.. (2016). Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(1), 152-160.
https://hdl.handle.net/21.15107/rcub_smile_2141

Dožić B, Glumac S, Boricić N, Dozić M, Aničić B, Boričić I. Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters. in Journal of BUON. 2016;21(1):152-160.
https://hdl.handle.net/21.15107/rcub_smile_2141 .

Dožić, Branko, Glumac, Sofija, Boricić, Novica, Dozić, Marko, Aničić, Boban, Boričić, Ivan, "Immunohistochemical expression of caspases 9 and 3 in adenoid cystic carcinoma of salivary glands and association with clinicopathological parameters" in Journal of BUON, 21, no. 1 (2016):152-160,
https://hdl.handle.net/21.15107/rcub_smile_2141 .