TY  - JOUR
AU  - Lazarević, Miloš
AU  - Milošević, Maja
AU  - Jelovac, Drago
AU  - Milenković, Sanja
AU  - Tepavčević, Zvezdana
AU  - Baldan, Federica
AU  - Suboticki, Tijana
AU  - Toljić, Boško
AU  - Trišić, Dijana
AU  - Dragović, Miroslav
AU  - Damante, Giuseppe
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2484
AB  - Epithelial to mesenchymal transition (EMT) is a feature of several types of human cancer, including oral squamous cell carcinoma (OSCC). In the present study, tumor and margin cell cultures obtained from patients with OSCC were used to determine the expression patterns of certain EMT-associated markers, including vimentin, alpha -smooth muscle actin, SLUG and SNAIL. In addition, other EMT-associated features, including clonal, proliferative and migratory potential were compared between the two cell types. Cell cultures were generated from tumor and margin tissue samples from 6 patients and cultured up to the fifth passage. EMT marker expression was assessed by reverse transcription-quantitative PCR. Cell proliferation, colony formation and scratch wound healing assays were conducted to characterize the two cell types in terms of proliferation rates, clonality and motility. All of the studied markers were expressed in tumor and margin cells. Although no significant differences were noted with regard to the aforementioned markers, their expression tended to be higher in margin cultures than in tumor cultures. The expressions of the EMT markers were also higher in the fifth passage compared with those noted at the first with a few exceptions. The rates of proliferation and cell migration were decreased during passages, while the number of colonies was increased in both types of cell culture. Tumor and margin cells indicated certain similarities with regard to EMT transition characteristics.
PB  - SPANDIDOS PUBL LTD, ATHENS
T2  - Oncology Letters
T1  - Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study
VL  - 19
IS  - 6
SP  - 3743
EP  - 3750
DO  - 10.3892/ol.2020.11494
ER  - 

@article{
author = "Lazarević, Miloš and Milošević, Maja and Jelovac, Drago and Milenković, Sanja and Tepavčević, Zvezdana and Baldan, Federica and Suboticki, Tijana and Toljić, Boško and Trišić, Dijana and Dragović, Miroslav and Damante, Giuseppe and Milašin, Jelena",
year = "2020",
abstract = "Epithelial to mesenchymal transition (EMT) is a feature of several types of human cancer, including oral squamous cell carcinoma (OSCC). In the present study, tumor and margin cell cultures obtained from patients with OSCC were used to determine the expression patterns of certain EMT-associated markers, including vimentin, alpha -smooth muscle actin, SLUG and SNAIL. In addition, other EMT-associated features, including clonal, proliferative and migratory potential were compared between the two cell types. Cell cultures were generated from tumor and margin tissue samples from 6 patients and cultured up to the fifth passage. EMT marker expression was assessed by reverse transcription-quantitative PCR. Cell proliferation, colony formation and scratch wound healing assays were conducted to characterize the two cell types in terms of proliferation rates, clonality and motility. All of the studied markers were expressed in tumor and margin cells. Although no significant differences were noted with regard to the aforementioned markers, their expression tended to be higher in margin cultures than in tumor cultures. The expressions of the EMT markers were also higher in the fifth passage compared with those noted at the first with a few exceptions. The rates of proliferation and cell migration were decreased during passages, while the number of colonies was increased in both types of cell culture. Tumor and margin cells indicated certain similarities with regard to EMT transition characteristics.",
publisher = "SPANDIDOS PUBL LTD, ATHENS",
journal = "Oncology Letters",
title = "Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study",
volume = "19",
number = "6",
pages = "3743-3750",
doi = "10.3892/ol.2020.11494"
}

Lazarević, M., Milošević, M., Jelovac, D., Milenković, S., Tepavčević, Z., Baldan, F., Suboticki, T., Toljić, B., Trišić, D., Dragović, M., Damante, G.,& Milašin, J.. (2020). Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study. in Oncology Letters
SPANDIDOS PUBL LTD, ATHENS., 19(6), 3743-3750.
https://doi.org/10.3892/ol.2020.11494

Lazarević M, Milošević M, Jelovac D, Milenković S, Tepavčević Z, Baldan F, Suboticki T, Toljić B, Trišić D, Dragović M, Damante G, Milašin J. Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study. in Oncology Letters. 2020;19(6):3743-3750.
doi:10.3892/ol.2020.11494 .

Lazarević, Miloš, Milošević, Maja, Jelovac, Drago, Milenković, Sanja, Tepavčević, Zvezdana, Baldan, Federica, Suboticki, Tijana, Toljić, Boško, Trišić, Dijana, Dragović, Miroslav, Damante, Giuseppe, Milašin, Jelena, "Marked epithelial to mesenchymal transition in surgical margins of oral cancer-an in vitro study" in Oncology Letters, 19, no. 6 (2020):3743-3750,
https://doi.org/10.3892/ol.2020.11494 . .

TY  - JOUR
AU  - Lisul, Bogdan
AU  - Jelovac, Drago
AU  - Petrović, Milan
AU  - Tepavčević, Zvezdana
AU  - Koruga, Đuro
AU  - Grga, Đurica
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2424
AB  - PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.
PB  - Springer Heidelberg, Heidelberg
T2  - Journal of Medical & Biological Engineering
T1  - Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins
VL  - 39
IS  - 6
SP  - 874
EP  - 884
DO  - 10.1007/s40846-019-00473-y
ER  - 

@article{
author = "Lisul, Bogdan and Jelovac, Drago and Petrović, Milan and Tepavčević, Zvezdana and Koruga, Đuro and Grga, Đurica",
year = "2019",
abstract = "PurposeNegative surgical margins status is of extreme importance for better prognosis and lower recurrence rate in patients undergoing surgical treatment for oral squamous cell carcinoma (OSCC). Standard histopathology is time consuming and current optical procedures come with various limitations. We examined the potential of a new imaging technique-opto-magnetic imaging spectroscopy (OMIS) in discriminating tumor (OSCC) from adjacent non-tumor oral cavity tissue.MethodsA total of 46 samples from 21 patients were included in this study. Samples were taken from a fresh surgical specimen of primary OSCC. Digital imaging of samples was performed within 60 min of resection using OMIS device. Images were processed through a specifically designed convolution algorithm based on light-matter interaction. As a result a convolution spectrum was generated. Predictive value of spectral data was assessed using correlation tests and Naive Bayes classification model.ResultsThere was no significant correlation in distribution of characteristic peaks between tumor and non-tumor tissue (P>0.05). Tumor tissue showed more magnetic activity compared to non-tumor tissue. Naive Bayes classifier with kernel density estimation discriminated tumor from non-tumor tissue with the accuracy of 82.61%, 86.96% sensitivity, 78.26% specificity and the AUC value of 0.917.ConclusionOMIS seems to be a promising optical method for ex vivo characterization of OSCC and non-tumor tissue. Further investigation is necessary to determine how tissue type and level of pathological transformation impact OMIS results. Ultimately, this could aid surgeons in using this method as an in vivo indicator for surgical resection with safe margins.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Journal of Medical & Biological Engineering",
title = "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins",
volume = "39",
number = "6",
pages = "874-884",
doi = "10.1007/s40846-019-00473-y"
}

Lisul, B., Jelovac, D., Petrović, M., Tepavčević, Z., Koruga, Đ.,& Grga, Đ.. (2019). Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering
Springer Heidelberg, Heidelberg., 39(6), 874-884.
https://doi.org/10.1007/s40846-019-00473-y

Lisul B, Jelovac D, Petrović M, Tepavčević Z, Koruga Đ, Grga Đ. Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins. in Journal of Medical & Biological Engineering. 2019;39(6):874-884.
doi:10.1007/s40846-019-00473-y .

Lisul, Bogdan, Jelovac, Drago, Petrović, Milan, Tepavčević, Zvezdana, Koruga, Đuro, Grga, Đurica, "Predictive Value of Opto-magnetic Imaging Spectroscopy in Discriminating Oral Squamous Cell Carcinoma from Non-tumor Tissue in Surgical Margins" in Journal of Medical & Biological Engineering, 39, no. 6 (2019):874-884,
https://doi.org/10.1007/s40846-019-00473-y . .

TY  - JOUR
AU  - Ćetenović, Bojana
AU  - Čolović, Božana
AU  - Vasilijić, Saša
AU  - Prokić, Bogomir
AU  - Pašalić, Snežana
AU  - Jokanović, Vukoman
AU  - Tepavčević, Zvezdana
AU  - Marković, Dejan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2275
AB  - The aim of this study was to investigate the biocompatibility of nanostructured materials based on highly active calcium silicates mixed with different radiocontrast agents in comparison to MTA(+) using in vitro and in vivo model. Morphology of materials' samples was analyzed using SEM while the phase compositions were identified by XRD. pH values of materials' suspensions were conducted by pH-meter. The cytotoxicity of materials' solutions was tested by MTT test (100, 50, 25 and 12.5mg/ml). LDH and H-3-thymidine assay were utilized for biocompatibility investigations of materials' eluates (24h, 7 day and 21 day). Eighteen Guinea pigs were used for intramuscular implantation, as teflon tubes with freshly prepared materials were placed into intramuscular pockets. All samples were composed of round and needle-like particles equally distributed with Ca/Si ratio 2.7 at%, with the presence of hydrated calcium silicate phases. The pH values of ALBO-MPCA(1) and ALBO-MPCA(2) were high alkaline, while in case of MTA(+) they were lower and continuously declined (p lt 0.05). Investigated materials didn't exhibit dose-dependent effect on metabolic activity of L929 cells (p>0.05). Significant differences in the percentage of cytotoxicity between diluted and undiluted extracts between all tested materials after 24h and 7 day were noticed (p lt 0.05). Increase in L929 cells proliferation was noticed in case of undiluted eluates of ALBO-MPCA(1) and ALBO-MPCA(2) after 7 day (p lt 0.05). There were no statistically significant differences in the intensity of inflammatory response between investigated materials and control group after 60 day (p>0.05). Evaluation of biocompatibility of both ALBO-MPCA(1) and ALBO-MPCA(2) indicate their potential clinical use. [GRAPHICS] .
PB  - Springer, Dordrecht
T2  - Journal of Materials Science-Materials in Medicine
T1  - Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study
VL  - 29
IS  - 12
DO  - 10.1007/s10856-018-6200-z
ER  - 

@article{
author = "Ćetenović, Bojana and Čolović, Božana and Vasilijić, Saša and Prokić, Bogomir and Pašalić, Snežana and Jokanović, Vukoman and Tepavčević, Zvezdana and Marković, Dejan",
year = "2018",
abstract = "The aim of this study was to investigate the biocompatibility of nanostructured materials based on highly active calcium silicates mixed with different radiocontrast agents in comparison to MTA(+) using in vitro and in vivo model. Morphology of materials' samples was analyzed using SEM while the phase compositions were identified by XRD. pH values of materials' suspensions were conducted by pH-meter. The cytotoxicity of materials' solutions was tested by MTT test (100, 50, 25 and 12.5mg/ml). LDH and H-3-thymidine assay were utilized for biocompatibility investigations of materials' eluates (24h, 7 day and 21 day). Eighteen Guinea pigs were used for intramuscular implantation, as teflon tubes with freshly prepared materials were placed into intramuscular pockets. All samples were composed of round and needle-like particles equally distributed with Ca/Si ratio 2.7 at%, with the presence of hydrated calcium silicate phases. The pH values of ALBO-MPCA(1) and ALBO-MPCA(2) were high alkaline, while in case of MTA(+) they were lower and continuously declined (p lt 0.05). Investigated materials didn't exhibit dose-dependent effect on metabolic activity of L929 cells (p>0.05). Significant differences in the percentage of cytotoxicity between diluted and undiluted extracts between all tested materials after 24h and 7 day were noticed (p lt 0.05). Increase in L929 cells proliferation was noticed in case of undiluted eluates of ALBO-MPCA(1) and ALBO-MPCA(2) after 7 day (p lt 0.05). There were no statistically significant differences in the intensity of inflammatory response between investigated materials and control group after 60 day (p>0.05). Evaluation of biocompatibility of both ALBO-MPCA(1) and ALBO-MPCA(2) indicate their potential clinical use. [GRAPHICS] .",
publisher = "Springer, Dordrecht",
journal = "Journal of Materials Science-Materials in Medicine",
title = "Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study",
volume = "29",
number = "12",
doi = "10.1007/s10856-018-6200-z"
}

Ćetenović, B., Čolović, B., Vasilijić, S., Prokić, B., Pašalić, S., Jokanović, V., Tepavčević, Z.,& Marković, D.. (2018). Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study. in Journal of Materials Science-Materials in Medicine
Springer, Dordrecht., 29(12).
https://doi.org/10.1007/s10856-018-6200-z

Ćetenović B, Čolović B, Vasilijić S, Prokić B, Pašalić S, Jokanović V, Tepavčević Z, Marković D. Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study. in Journal of Materials Science-Materials in Medicine. 2018;29(12).
doi:10.1007/s10856-018-6200-z .

Ćetenović, Bojana, Čolović, Božana, Vasilijić, Saša, Prokić, Bogomir, Pašalić, Snežana, Jokanović, Vukoman, Tepavčević, Zvezdana, Marković, Dejan, "Nanostructured endodontic materials mixed with different radiocontrast agentsbiocompatibility study" in Journal of Materials Science-Materials in Medicine, 29, no. 12 (2018),
https://doi.org/10.1007/s10856-018-6200-z . .

TY  - JOUR
AU  - Jelovac, Drago
AU  - Tepavčević, Zvezdana
AU  - Nikolić, Nadja
AU  - Ilić, Branislav
AU  - Eljabo, Najib
AU  - Popović, Branka
AU  - Čarkić, Jelena
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2180
AB  - The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P = 0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.
PB  - Churchill Livingstone, Edinburgh
T2  - International Journal of Oral & Maxillofacial Surgery
T1  - The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma
VL  - 45
IS  - 6
SP  - 700
EP  - 705
DO  - 10.1016/j.ijom.2015.11.014
ER  - 

@article{
author = "Jelovac, Drago and Tepavčević, Zvezdana and Nikolić, Nadja and Ilić, Branislav and Eljabo, Najib and Popović, Branka and Čarkić, Jelena and Konstantinović, Vitomir and Vukadinović, Miroslav and Miličić, Biljana and Milašin, Jelena",
year = "2016",
abstract = "The tumour subtype, TNM classification, and histopathological data are sometimes not sufficient for understanding and assessing the behaviour of oral cancers. In an attempt to find additional markers of tumour biology and behaviour, this study sought to determine the incidence and consequently the relevance of c-erb-B2, c-Myc, and H-ras gene alterations in tumour-free margins of oral squamous cell carcinoma (OSCC). Fifty samples of OSCC were analyzed for c-erb-B2 and c-Myc amplification by real-time polymerase chain reaction and for H-ras point mutations by sequencing. A relatively high incidence of genetic lesions was detected: 22% of cases had c-erb-B2 and 30% had c-Myc amplification, whilst only 12% harboured H-ras mutations. Kaplan-Meier analysis and the log-rank test showed statistically significant differences in 5-year survival rates and relapse between patients with tumour margins positive for c-erb-B2 amplification and those with margins that were negative (P = 0.002). H-ras and c-Myc alterations could not be associated with tumour behaviour. Molecular analysis of margins, targeting cancer genes, could identify additional, independent predictors of risk and outcome in OSCC.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "International Journal of Oral & Maxillofacial Surgery",
title = "The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma",
volume = "45",
number = "6",
pages = "700-705",
doi = "10.1016/j.ijom.2015.11.014"
}

Jelovac, D., Tepavčević, Z., Nikolić, N., Ilić, B., Eljabo, N., Popović, B., Čarkić, J., Konstantinović, V., Vukadinović, M., Miličić, B.,& Milašin, J.. (2016). The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery
Churchill Livingstone, Edinburgh., 45(6), 700-705.
https://doi.org/10.1016/j.ijom.2015.11.014

Jelovac D, Tepavčević Z, Nikolić N, Ilić B, Eljabo N, Popović B, Čarkić J, Konstantinović V, Vukadinović M, Miličić B, Milašin J. The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma. in International Journal of Oral & Maxillofacial Surgery. 2016;45(6):700-705.
doi:10.1016/j.ijom.2015.11.014 .

Jelovac, Drago, Tepavčević, Zvezdana, Nikolić, Nadja, Ilić, Branislav, Eljabo, Najib, Popović, Branka, Čarkić, Jelena, Konstantinović, Vitomir, Vukadinović, Miroslav, Miličić, Biljana, Milašin, Jelena, "The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma" in International Journal of Oral & Maxillofacial Surgery, 45, no. 6 (2016):700-705,
https://doi.org/10.1016/j.ijom.2015.11.014 . .

TY  - JOUR
AU  - Brajić, Ivana
AU  - Skodrić, Sanja
AU  - Milenković, S.
AU  - Tepavčević, Zvezdana
AU  - Soldatović, Ivan
AU  - Čolić, Snježana
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2140
AB  - ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.
PB  - Wiley-Blackwell, Hoboken
T2  - Oral Diseases
T1  - Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression
VL  - 22
IS  - 3
SP  - 220
EP  - 225
DO  - 10.1111/odi.12414
ER  - 

@article{
author = "Brajić, Ivana and Skodrić, Sanja and Milenković, S. and Tepavčević, Zvezdana and Soldatović, Ivan and Čolić, Snježana and Milašin, Jelena and Andrić, Miroslav",
year = "2016",
abstract = "ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression",
volume = "22",
number = "3",
pages = "220-225",
doi = "10.1111/odi.12414"
}

Brajić, I., Skodrić, S., Milenković, S., Tepavčević, Z., Soldatović, I., Čolić, S., Milašin, J.,& Andrić, M.. (2016). Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases
Wiley-Blackwell, Hoboken., 22(3), 220-225.
https://doi.org/10.1111/odi.12414

Brajić I, Skodrić S, Milenković S, Tepavčević Z, Soldatović I, Čolić S, Milašin J, Andrić M. Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases. 2016;22(3):220-225.
doi:10.1111/odi.12414 .

Brajić, Ivana, Skodrić, Sanja, Milenković, S., Tepavčević, Zvezdana, Soldatović, Ivan, Čolić, Snježana, Milašin, Jelena, Andrić, Miroslav, "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression" in Oral Diseases, 22, no. 3 (2016):220-225,
https://doi.org/10.1111/odi.12414 . .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Čarkić, Jelena
AU  - Simonović, Jelena
AU  - Toljić, Boško
AU  - Tanić, Nasta
AU  - Tepavčević, Zvezdana
AU  - Vukadinović, Miroslav
AU  - Konstantinović, Vitomir
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2019
AB  - Objectives: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. Materials and Methods: Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. Results: Promoter hypermethylation of the two genes was a very frequent event in both neoplasms between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P = 0.00), and significantly decreased in comparison to the carcinoma group (P = 0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P = 0.044 and P = 0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P = 0.013). Conclusion: Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and Pl4(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors
VL  - 60
IS  - 11
SP  - 1662
EP  - 1666
DO  - 10.1016/j.archoralbio.2015.08.011
ER  - 

@article{
author = "Nikolić, Nadja and Aničić, Boban and Čarkić, Jelena and Simonović, Jelena and Toljić, Boško and Tanić, Nasta and Tepavčević, Zvezdana and Vukadinović, Miroslav and Konstantinović, Vitomir and Milašin, Jelena",
year = "2015",
abstract = "Objectives: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands. Materials and Methods: Genomic DNA from paraffin-embedded samples of 50 pleomorphic adenomas and 10 carcinomas ex pleomorphic adenoma was subjected to methylation specific polymerase chain reaction for hypermethylation analyses and real time polymerase chain reaction for the relative telomere length calculations. Results: Promoter hypermethylation of the two genes was a very frequent event in both neoplasms between 60% and 90% of samples were hypermethylated - but without significant difference between the groups. The mean relative telomere length in the pleomorphic adenoma group was significantly increased in comparison to the control group (P = 0.00), and significantly decreased in comparison to the carcinoma group (P = 0.05). Telomeres were also longer in myxoid and cellular histological subtypes of adenomas than in the classic type (P = 0.044 and P = 0.018, respectively). Longer telomeres were more frequent in tumors with hypermethylated p14(ARF) alleles (P = 0.013). Conclusion: Promoter hypermethylations seems to be an important mechanism of p16(INK4a) and Pl4(ARF) inactivation in parotid gland tumors. Telomeric lengthening appears to be involved in the pathogenesis of both benign and malignant tumors of the parotid glands.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors",
volume = "60",
number = "11",
pages = "1662-1666",
doi = "10.1016/j.archoralbio.2015.08.011"
}

Nikolić, N., Aničić, B., Čarkić, J., Simonović, J., Toljić, B., Tanić, N., Tepavčević, Z., Vukadinović, M., Konstantinović, V.,& Milašin, J.. (2015). High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 60(11), 1662-1666.
https://doi.org/10.1016/j.archoralbio.2015.08.011

Nikolić N, Aničić B, Čarkić J, Simonović J, Toljić B, Tanić N, Tepavčević Z, Vukadinović M, Konstantinović V, Milašin J. High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors. in Archives of Oral Biology. 2015;60(11):1662-1666.
doi:10.1016/j.archoralbio.2015.08.011 .

Nikolić, Nadja, Aničić, Boban, Čarkić, Jelena, Simonović, Jelena, Toljić, Boško, Tanić, Nasta, Tepavčević, Zvezdana, Vukadinović, Miroslav, Konstantinović, Vitomir, Milašin, Jelena, "High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors" in Archives of Oral Biology, 60, no. 11 (2015):1662-1666,
https://doi.org/10.1016/j.archoralbio.2015.08.011 . .

TY  - JOUR
AU  - Ilic-Dimitrijević, Ivana
AU  - Loening, Thomas
AU  - Falk, Marcus
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Tepavčević, Zvezdana
AU  - Tabaković, Saša Z.
AU  - Pejčić, Nataša
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1926
AB  - Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.
PB  - Društvo genetičara Srbije, Beograd
T2  - Genetika - Belgrade
T1  - Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma
VL  - 46
IS  - 2
SP  - 601
EP  - 610
DO  - 10.2298/GENSR1402601D
ER  - 

@article{
author = "Ilic-Dimitrijević, Ivana and Loening, Thomas and Falk, Marcus and Konstantinović, Vitomir and Vukadinović, Miroslav and Tepavčević, Zvezdana and Tabaković, Saša Z. and Pejčić, Nataša and Miličić, Biljana and Milašin, Jelena",
year = "2014",
abstract = "Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika - Belgrade",
title = "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma",
volume = "46",
number = "2",
pages = "601-610",
doi = "10.2298/GENSR1402601D"
}

Ilic-Dimitrijević, I., Loening, T., Falk, M., Konstantinović, V., Vukadinović, M., Tepavčević, Z., Tabaković, S. Z., Pejčić, N., Miličić, B.,& Milašin, J.. (2014). Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade
Društvo genetičara Srbije, Beograd., 46(2), 601-610.
https://doi.org/10.2298/GENSR1402601D

Ilic-Dimitrijević I, Loening T, Falk M, Konstantinović V, Vukadinović M, Tepavčević Z, Tabaković SZ, Pejčić N, Miličić B, Milašin J. Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma. in Genetika - Belgrade. 2014;46(2):601-610.
doi:10.2298/GENSR1402601D .

Ilic-Dimitrijević, Ivana, Loening, Thomas, Falk, Marcus, Konstantinović, Vitomir, Vukadinović, Miroslav, Tepavčević, Zvezdana, Tabaković, Saša Z., Pejčić, Nataša, Miličić, Biljana, Milašin, Jelena, "Incidence and clinical relevance of t(11;19) translocation in salivary gland mucoepidermoid carcinoma" in Genetika - Belgrade, 46, no. 2 (2014):601-610,
https://doi.org/10.2298/GENSR1402601D . .

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Aničić, Boban
AU  - Tepavčević, Zvezdana
AU  - Jezdić, Zoran
AU  - Čarkić, Jelena
AU  - Toljić, Boško
AU  - Dedović-Tanić, Nasta
AU  - Konstantinović, Vitomir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1779
AB  - Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population.
AB  - Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands
T1  - Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda
VL  - 32
IS  - 4
SP  - 354
EP  - 360
DO  - 10.2478/jomb-2013-0048
ER  - 

@article{
author = "Nikolić, Nadja and Aničić, Boban and Tepavčević, Zvezdana and Jezdić, Zoran and Čarkić, Jelena and Toljić, Boško and Dedović-Tanić, Nasta and Konstantinović, Vitomir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2013",
abstract = "Background: Genetic studies of salivary gland neoplasms were mainly focused on chromosomal changes, and some specific patterns of chromosome translocations have been described. However, molecular alterations, in particular the role of HER-2/H-ras/c-myc signalling cascade in pleomorphic adenoma pathogenesis (PA), are less well characterized. In addition, data on single nucleotide polymorphisms (SNPs) as potential susceptibility factors for PA development are also quite scarce. Methods: Mutational analyses were performed by means of real-time PCR (HER-2 and c-myc amplification analysis), PCR-SSCP and sequencing (H-ras point mutation detection). Polymorphisms analysis was performed by PCR-RFLP (survivin and MMP-9 genes). Results: Amplification of HER-2 and c-myc has been found in 13% and 9% of PA cases respectively. Point mutations in H-ras codons 12/13 have been detected in 17% of PAs. No correlation could be established between these alterations and clinical characteristics of PAs, whereas they might play a role in a subset of malignant salivary gland tumours. As for survivin -31 G/C polymorphism, C allele carriers had a 4-fold decrease of the risk of developing PA (p=0.05). Carriers of the variant allele T of the -1562C/T SNP in MMP-9 gene had a 4-fold increase of the risk of developing PA (p lt 0.001). Conclusions: A longer follow-up of PA patients harbouring mutations could uncover a prognostic role of HER-2 and c-myc amplification as predictors of adenoma transformation into carcinoma. Both survivin and MMP-9 promoter polymorphisms represent susceptibility factors for the development of PAs in the Serbian population., Uvod: U ispitivanjima mehanizama nastanka tumora pljuvačnih žlezda uglavnom dominiraju citogenetičke studije, pa su tako detektovane i opisane različite hromozomske translokacije sa specifičnim obrascem javljanja. Međutim, molekularne promene u ovim tumorima i dalje su relativno slabo poznate, a pogotovo je malo podataka o potencijalnom značaju signalnog puta HER-2/H-ras/c-myc u razvoju i progresiji pleomorfnih adenoma (PA). Takođe, retki su i podaci 0 polimorfizmima pojedinačnog nukleotida (SNP) kao faktora predispozicije za nastanak PA. Metode: Analize somatskih mutacija urađene su metodama real-time PCR (analiza amplifikacije HER-2 i c-myc), PCR-SSCP i sekvenciranja (detekcija tačkastih mutacija u H-ras). Ana I iza polimorfizama pojedinačnih nukleotida (SNP) vršena je prime- nom metode PCR-RFLP (u genima za survivin i MMP-9). Rezultati: Amplifikacija gena HER-2 detektovana je u 13%, c-myc u 9% a tačkaste mutacije u kodonima 12/13 H-ras gena u 17% uzoraka. Nije ustanovljena veza između ovih promena i kliničkih odlika adenoma. Na malom uzorku karcinoma, pokazano je da je amplifikacija HER-2 povezana sa recidivima tumora. Nosioci C alela u -31G/C SNP gena za survivin imaju četiri puta manji rizik od nastanka PA (p=0,05), dok nosioci varijantnog alela T kod -1562 C/T SNP u MMP-9 genu imaju četiri puta veći rizik da obole od PA u odnosu na kontrolu (p lt 0,001). Zaključak: Dužim praćenjem pacijenata sa PA mogla bi da se ustanovi prognostička uloga HER-2 i c-myc amplifikacija kao indikatora za transformaciju adenoma u karcinom. Polimorfizmi u promotorima gena za survivin i MMP-9 predstavljaju modulatore rizika za razvoj pleomorfnih adenoma u srpskoj populaciji.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands, Somatske mutacije i analiza polimorfizama u pleomorfnim adenomima pljuvačnih žlezda",
volume = "32",
number = "4",
pages = "354-360",
doi = "10.2478/jomb-2013-0048"
}

Nikolić, N., Aničić, B., Tepavčević, Z., Jezdić, Z., Čarkić, J., Toljić, B., Dedović-Tanić, N., Konstantinović, V., Vukadinović, M.,& Milašin, J.. (2013). Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 32(4), 354-360.
https://doi.org/10.2478/jomb-2013-0048

Nikolić N, Aničić B, Tepavčević Z, Jezdić Z, Čarkić J, Toljić B, Dedović-Tanić N, Konstantinović V, Vukadinović M, Milašin J. Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands. in Journal of Medical Biochemistry. 2013;32(4):354-360.
doi:10.2478/jomb-2013-0048 .

Nikolić, Nadja, Aničić, Boban, Tepavčević, Zvezdana, Jezdić, Zoran, Čarkić, Jelena, Toljić, Boško, Dedović-Tanić, Nasta, Konstantinović, Vitomir, Vukadinović, Miroslav, Milašin, Jelena, "Somatic mutation and polymorphism analysis in pleomorphic adenomas of the salivary glands" in Journal of Medical Biochemistry, 32, no. 4 (2013):354-360,
https://doi.org/10.2478/jomb-2013-0048 . .

TY  - JOUR
AU  - Sopta, Jelena
AU  - Dražić, Radojica
AU  - Tulić, Goran
AU  - Mijucić, Vesna
AU  - Tepavčević, Zvezdana
PY  - 2011
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1624
AB  - Cemento-ossifying fibroma (COF) belongs to the group of bone-related lesions of the oral cavity. The aim of this study was refine its histologic features and to correlate histopathological picture and clinical behavior of the tumor. The quantity of bone spherules, their cellularity, the existence of hemorrhage, inflammation, and endochondral ossification in the stroma of the tumor were analyzed and correlated with patients main symptoms of ten patients with COF. All patients had swelling that lasted between 3 and 20 months (mean 10.4 months). Other clinical symptoms were facial asymmetry, eye bulb protrusion, and teeth displacement. The evolution of the tumor was longer in the mandible (12.3 months) than in maxilla (9.5 months). The main histomorphological diagnostic criterion for COF was psammoma-like structures. In lesions with longer case history, the number of "psammomatoid" bodies was greater. In lesions with shorter course of the disease, their number was lower and stromal hemorrhage and inflammation were presented. One patient had secondary superposition of aneurysmal bone cyst in the prime COF of mandible. Histological appearance of COF may be influenced by the tumor evolution. A siginificant correlation between the clinical course of the disease and histological parameters has been certified.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Cemento-ossifying fibroma of jaws-correlation of clinical and pathological findings
VL  - 15
IS  - 2
SP  - 201
EP  - 207
DO  - 10.1007/s00784-010-0381-2
ER  - 

@article{
author = "Sopta, Jelena and Dražić, Radojica and Tulić, Goran and Mijucić, Vesna and Tepavčević, Zvezdana",
year = "2011",
abstract = "Cemento-ossifying fibroma (COF) belongs to the group of bone-related lesions of the oral cavity. The aim of this study was refine its histologic features and to correlate histopathological picture and clinical behavior of the tumor. The quantity of bone spherules, their cellularity, the existence of hemorrhage, inflammation, and endochondral ossification in the stroma of the tumor were analyzed and correlated with patients main symptoms of ten patients with COF. All patients had swelling that lasted between 3 and 20 months (mean 10.4 months). Other clinical symptoms were facial asymmetry, eye bulb protrusion, and teeth displacement. The evolution of the tumor was longer in the mandible (12.3 months) than in maxilla (9.5 months). The main histomorphological diagnostic criterion for COF was psammoma-like structures. In lesions with longer case history, the number of "psammomatoid" bodies was greater. In lesions with shorter course of the disease, their number was lower and stromal hemorrhage and inflammation were presented. One patient had secondary superposition of aneurysmal bone cyst in the prime COF of mandible. Histological appearance of COF may be influenced by the tumor evolution. A siginificant correlation between the clinical course of the disease and histological parameters has been certified.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Cemento-ossifying fibroma of jaws-correlation of clinical and pathological findings",
volume = "15",
number = "2",
pages = "201-207",
doi = "10.1007/s00784-010-0381-2"
}

Sopta, J., Dražić, R., Tulić, G., Mijucić, V.,& Tepavčević, Z.. (2011). Cemento-ossifying fibroma of jaws-correlation of clinical and pathological findings. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 15(2), 201-207.
https://doi.org/10.1007/s00784-010-0381-2

Sopta J, Dražić R, Tulić G, Mijucić V, Tepavčević Z. Cemento-ossifying fibroma of jaws-correlation of clinical and pathological findings. in Clinical Oral Investigations. 2011;15(2):201-207.
doi:10.1007/s00784-010-0381-2 .

Sopta, Jelena, Dražić, Radojica, Tulić, Goran, Mijucić, Vesna, Tepavčević, Zvezdana, "Cemento-ossifying fibroma of jaws-correlation of clinical and pathological findings" in Clinical Oral Investigations, 15, no. 2 (2011):201-207,
https://doi.org/10.1007/s00784-010-0381-2 . .

TY  - JOUR
AU  - Krstić, Nikola
AU  - Pešut, Olivera
AU  - Marković, Dejan
AU  - Tepavčević, Zvezdana
AU  - Hadžimilić, Milan
AU  - Milosavljević, Željko
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1463
AB  - Analyses of the viscerocranial parameters in dogs has been avoided due to inconsistencies in defining the reference points for linear and angular measurements. In our study we classified the elements which refer to the balance of skeletal structures and teeth in relation to other osseous elements. By X-ray-photoimaging spatial relations within the osseous system of the head of German Shepherd dogs angular parameters (gonial angle Go, the angles Iv, SNA, SNB, ANB and NSBa) were constructed. Sagittal positions or inclinations of the upper and lower incisors were determined by angles C and D and their relationship was determined by the interincisal angle E. The position of the upper and lower eyeteeth in relation to the basic plane of the maxilla and mandible was determined by the numerical values of angles F and G. The opportunity to define the type of growth, and the changes between the face and the skull base, was provided by constructing the following angles of the polygon, as well as by the exact determination of their individual and total values:  lt SarGo,  lt NSAr,  lt ArGoIv,  lt GoIvMe.
AB  - Telerendgenske analize viscerokranijalnih parametara su izbegavane usled toga što referentne tačke za linearna i angularna merenja nisu bile definisane. U našem radu, klasifikovani su elementi koji se odnose na ravnotežu skeletnih struktura i zuba u odnosu na ostale kostne anatomske entitete glave. Prostorni odnosi na kostnom sistemu glave pasa rase nemački ovčar, utvrđeni su konstrukcijom i numeričkim određivanjem najznačajnijih uglovnih parametara: gonijalni ugao Go, uglovi Iv, SNA, SNB, ANB, NSBa. Sagitalni položaji ili nagibi gornjih i donjih sekutić a određeni su preko uglova C i D, a odnos između ova dva parametra konstrukcijom interincizalnog ugla E. Položaj gornjih i donjih očnjaka u odnosu na osnovnu ravan maksile i mandibule determinisan je egzaktnim numeričkim vrednostima uglova F i G. Definisanje tipa rasta lica i promene odnosa lica i baze lobanje omogućeno je formiranjem sledećih uglova poligona, kao i egzaktnim određivanjem njihovih pojedinačnih i zbirnih vrednosti:  lt SarGo,  lt NSAr,  lt Ar- GoIv,  lt GoIvMe.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - X-ray craniometric and x-ray cephalometric determination of angular parameters in German shepherd dogs
T1  - Rendgenkraniometrijsko i rendgenkefalometrijsko određivanje angularnih parametara kod pasa rase nemački ovčar
VL  - 59
IS  - 2-3
SP  - 255
EP  - 265
DO  - 10.2298/AVB0903255K
ER  - 

@article{
author = "Krstić, Nikola and Pešut, Olivera and Marković, Dejan and Tepavčević, Zvezdana and Hadžimilić, Milan and Milosavljević, Željko",
year = "2009",
abstract = "Analyses of the viscerocranial parameters in dogs has been avoided due to inconsistencies in defining the reference points for linear and angular measurements. In our study we classified the elements which refer to the balance of skeletal structures and teeth in relation to other osseous elements. By X-ray-photoimaging spatial relations within the osseous system of the head of German Shepherd dogs angular parameters (gonial angle Go, the angles Iv, SNA, SNB, ANB and NSBa) were constructed. Sagittal positions or inclinations of the upper and lower incisors were determined by angles C and D and their relationship was determined by the interincisal angle E. The position of the upper and lower eyeteeth in relation to the basic plane of the maxilla and mandible was determined by the numerical values of angles F and G. The opportunity to define the type of growth, and the changes between the face and the skull base, was provided by constructing the following angles of the polygon, as well as by the exact determination of their individual and total values:  lt SarGo,  lt NSAr,  lt ArGoIv,  lt GoIvMe., Telerendgenske analize viscerokranijalnih parametara su izbegavane usled toga što referentne tačke za linearna i angularna merenja nisu bile definisane. U našem radu, klasifikovani su elementi koji se odnose na ravnotežu skeletnih struktura i zuba u odnosu na ostale kostne anatomske entitete glave. Prostorni odnosi na kostnom sistemu glave pasa rase nemački ovčar, utvrđeni su konstrukcijom i numeričkim određivanjem najznačajnijih uglovnih parametara: gonijalni ugao Go, uglovi Iv, SNA, SNB, ANB, NSBa. Sagitalni položaji ili nagibi gornjih i donjih sekutić a određeni su preko uglova C i D, a odnos između ova dva parametra konstrukcijom interincizalnog ugla E. Položaj gornjih i donjih očnjaka u odnosu na osnovnu ravan maksile i mandibule determinisan je egzaktnim numeričkim vrednostima uglova F i G. Definisanje tipa rasta lica i promene odnosa lica i baze lobanje omogućeno je formiranjem sledećih uglova poligona, kao i egzaktnim određivanjem njihovih pojedinačnih i zbirnih vrednosti:  lt SarGo,  lt NSAr,  lt Ar- GoIv,  lt GoIvMe.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "X-ray craniometric and x-ray cephalometric determination of angular parameters in German shepherd dogs, Rendgenkraniometrijsko i rendgenkefalometrijsko određivanje angularnih parametara kod pasa rase nemački ovčar",
volume = "59",
number = "2-3",
pages = "255-265",
doi = "10.2298/AVB0903255K"
}

Krstić, N., Pešut, O., Marković, D., Tepavčević, Z., Hadžimilić, M.,& Milosavljević, Ž.. (2009). X-ray craniometric and x-ray cephalometric determination of angular parameters in German shepherd dogs. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 59(2-3), 255-265.
https://doi.org/10.2298/AVB0903255K

Krstić N, Pešut O, Marković D, Tepavčević Z, Hadžimilić M, Milosavljević Ž. X-ray craniometric and x-ray cephalometric determination of angular parameters in German shepherd dogs. in Acta veterinaria. 2009;59(2-3):255-265.
doi:10.2298/AVB0903255K .

Krstić, Nikola, Pešut, Olivera, Marković, Dejan, Tepavčević, Zvezdana, Hadžimilić, Milan, Milosavljević, Željko, "X-ray craniometric and x-ray cephalometric determination of angular parameters in German shepherd dogs" in Acta veterinaria, 59, no. 2-3 (2009):255-265,
https://doi.org/10.2298/AVB0903255K . .

TY  - JOUR
AU  - Popović, Branka
AU  - Jekić, B.
AU  - Novaković, I.
AU  - Luković, Ljiljana
AU  - Tepavčević, Zvezdana
AU  - Jurišić, Vladimir
AU  - Vukadinović, Miroslav
AU  - Milašin, Jelena
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1329
AB  - Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].
PB  - Wiley-Blackwell, Hoboken
T2  - Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
T1  - Bcl-2 expression in oral squamous cell carcinoma
VL  - 1095
SP  - 19
EP  - 25
DO  - 10.1196/annals.1397.003
ER  - 

@article{
author = "Popović, Branka and Jekić, B. and Novaković, I. and Luković, Ljiljana and Tepavčević, Zvezdana and Jurišić, Vladimir and Vukadinović, Miroslav and Milašin, Jelena",
year = "2007",
abstract = "Apoptosis is a genetically regulated process involved in tissue size regulation, morphogenesis, and elimination of genetically damaged cells. A pallet of genes is involved in the control of apoptosis, such as bcl-2 family whose oncogenic potential has been demonstrated in oral tumorigenesis. Different members of bcl-2 family may promote or inhibit apoptosis by synthesizing anti- and proapoptotic proteins. One of antiapoptotic proteins, bcl-2, with a crucial role in apoptosis regulation was the object of our study. By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC). Analyzed tumors originated from different sites of oral cavity; 7/26 belonged to stage II, 14/26 to stage III, and 5/26 to stage IV Immunoreactivity was scored according to the percentage and intensity of positive cytoplasmic bcl-2 staining. All tumors had low percentage of positively stained bcl-2 cells, with mean values for lower/higher intensity of 8.3 +/- 2.5/34.4 +/- 7, 7.5 +/- 1.1/31.9 +/- 4.3, and 8.4 +/- 5.8/31.5 +/- 5.8 within stages II,III, and IV, respectively. Low level of bcl-2 expression in our sample seems to be associated with higher survival rate: 77% for the 5-year follow-up period. Comparing clinicopathologic and risk factors data within each and between three groups of analyzed tumors (lip-tongue P = 0.58, tongue-floor of the mouth, P = 0.21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, [sic].",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease",
title = "Bcl-2 expression in oral squamous cell carcinoma",
volume = "1095",
pages = "19-25",
doi = "10.1196/annals.1397.003"
}

Popović, B., Jekić, B., Novaković, I., Luković, L., Tepavčević, Z., Jurišić, V., Vukadinović, M.,& Milašin, J.. (2007). Bcl-2 expression in oral squamous cell carcinoma. in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease
Wiley-Blackwell, Hoboken., 1095, 19-25.
https://doi.org/10.1196/annals.1397.003

Popović B, Jekić B, Novaković I, Luković L, Tepavčević Z, Jurišić V, Vukadinović M, Milašin J. Bcl-2 expression in oral squamous cell carcinoma. in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease. 2007;1095:19-25.
doi:10.1196/annals.1397.003 .

Popović, Branka, Jekić, B., Novaković, I., Luković, Ljiljana, Tepavčević, Zvezdana, Jurišić, Vladimir, Vukadinović, Miroslav, Milašin, Jelena, "Bcl-2 expression in oral squamous cell carcinoma" in Signal Transduction Pathways, Pt C: Cell Signaling in Health & Disease, 1095 (2007):19-25,
https://doi.org/10.1196/annals.1397.003 . .

TY  - JOUR
AU  - Krstić, Nikola
AU  - Milosavljević, Željko
AU  - Tepavčević, Zvezdana
PY  - 2002
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1160
AB  - After rentgencraniornetric and roentgencephalometric analysis of the most significant reference points for dogs of the German Shepherd breed aged 12 months, we considered it would be of importance, both from the scientific and cynologic point of view, to determine all linear parameters which might be used in the exact type classification of the neuroviscerocranium of these animals. Correct proportions of certain regions of the face and head were exactly determined by defining and numerical specifying the following lines line N (Nasion)- S (Sella), bispinal or palatine plane alpha (SnA- SnP) occlusive plane- beta, plane gamma (Go- Me) and line N-A. The line N-Iv denotes the middle height of the face which is specific for the mesocephalic type of dogs head. In addition to these, there are also the lines Co Condylion) - Go (Gonion), Go (Gonion) - Me (Menton) and line S (Sella) Go (Gonion). A full inspection of the harmony and anatomic balance in the proportions of the neuroviscerocranium skeleton was achieved by specifying the following linear parameters for the frontal photograph: the lines Zy- Zy (Zygon), Eu- Eu (between the Eurion points), the lines Em- Em, ecm- ecm Eim- Eim, Go- Go, the distances En- En, Ein- Bin, Ecm- Ecm, Ecp- Ecp and Ecl- Ecl.
AB  - Rendgenkraniometrijskom i rendgenkefalometrijskom analizom najznačajnijih referentnih tačaka kod pasa rase nemački ovčar starosti 12 meseci određivani su linearni parametri koji bi se mogli koristiti u egzaktnoj tipizaciji neuroviscerokranijuma ovih životinja. Pravilni odnosi pojedinih regija lica i glave egzaktno su utvrđeni definisanjem i numeričkim određivanjem sledećih linija: linija N (Nasion)- S (Sella), bispinalna ili palatinalna ravan alfa (SnA- SnP), okluzana ravan- beta, ravan gama (Go- Me) i linija N-A. Linija N-lv predstavlja srednju visinu lica osobenu za mezocefalni tip glave psa. Pored ovih postoje još i linije Co (Condylion) Go (Gonion)- Me (Menton) i linija S (Sella)- Go (Gonion), Potpuni uvid u skladnost i anatomsku ravnotežu skeletnog odnosa neuroviscerokranijuma dobijen je određivanjem sledećih linearnih parametara na frontalnom snimku linija Zy-Zy (Zygion), Eu-Eu (između tačaka Eurion), linija Em-Em, ecm-ecm Eim-Eim, Go-Go, rastojanje En-En, Ein-Ein, Ecm-Ecm, Ecp-Ecp i Ecl-Ecl.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Roentgencraniometric and roent-gencenphalometric determination of linear parameters on dogs of German Shepard breed
T1  - Rendgenkraniometrijsko i rendgenkefalometrisjko ispitivanje linearnih parametara pasa rase nemački ovčar
VL  - 52
IS  - 2-3
SP  - 181
EP  - 196
DO  - 10.2298/AVB0203181K
ER  - 

@article{
author = "Krstić, Nikola and Milosavljević, Željko and Tepavčević, Zvezdana",
year = "2002",
abstract = "After rentgencraniornetric and roentgencephalometric analysis of the most significant reference points for dogs of the German Shepherd breed aged 12 months, we considered it would be of importance, both from the scientific and cynologic point of view, to determine all linear parameters which might be used in the exact type classification of the neuroviscerocranium of these animals. Correct proportions of certain regions of the face and head were exactly determined by defining and numerical specifying the following lines line N (Nasion)- S (Sella), bispinal or palatine plane alpha (SnA- SnP) occlusive plane- beta, plane gamma (Go- Me) and line N-A. The line N-Iv denotes the middle height of the face which is specific for the mesocephalic type of dogs head. In addition to these, there are also the lines Co Condylion) - Go (Gonion), Go (Gonion) - Me (Menton) and line S (Sella) Go (Gonion). A full inspection of the harmony and anatomic balance in the proportions of the neuroviscerocranium skeleton was achieved by specifying the following linear parameters for the frontal photograph: the lines Zy- Zy (Zygon), Eu- Eu (between the Eurion points), the lines Em- Em, ecm- ecm Eim- Eim, Go- Go, the distances En- En, Ein- Bin, Ecm- Ecm, Ecp- Ecp and Ecl- Ecl., Rendgenkraniometrijskom i rendgenkefalometrijskom analizom najznačajnijih referentnih tačaka kod pasa rase nemački ovčar starosti 12 meseci određivani su linearni parametri koji bi se mogli koristiti u egzaktnoj tipizaciji neuroviscerokranijuma ovih životinja. Pravilni odnosi pojedinih regija lica i glave egzaktno su utvrđeni definisanjem i numeričkim određivanjem sledećih linija: linija N (Nasion)- S (Sella), bispinalna ili palatinalna ravan alfa (SnA- SnP), okluzana ravan- beta, ravan gama (Go- Me) i linija N-A. Linija N-lv predstavlja srednju visinu lica osobenu za mezocefalni tip glave psa. Pored ovih postoje još i linije Co (Condylion) Go (Gonion)- Me (Menton) i linija S (Sella)- Go (Gonion), Potpuni uvid u skladnost i anatomsku ravnotežu skeletnog odnosa neuroviscerokranijuma dobijen je određivanjem sledećih linearnih parametara na frontalnom snimku linija Zy-Zy (Zygion), Eu-Eu (između tačaka Eurion), linija Em-Em, ecm-ecm Eim-Eim, Go-Go, rastojanje En-En, Ein-Ein, Ecm-Ecm, Ecp-Ecp i Ecl-Ecl.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Roentgencraniometric and roent-gencenphalometric determination of linear parameters on dogs of German Shepard breed, Rendgenkraniometrijsko i rendgenkefalometrisjko ispitivanje linearnih parametara pasa rase nemački ovčar",
volume = "52",
number = "2-3",
pages = "181-196",
doi = "10.2298/AVB0203181K"
}

Krstić, N., Milosavljević, Ž.,& Tepavčević, Z.. (2002). Roentgencraniometric and roent-gencenphalometric determination of linear parameters on dogs of German Shepard breed. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 52(2-3), 181-196.
https://doi.org/10.2298/AVB0203181K

Krstić N, Milosavljević Ž, Tepavčević Z. Roentgencraniometric and roent-gencenphalometric determination of linear parameters on dogs of German Shepard breed. in Acta veterinaria. 2002;52(2-3):181-196.
doi:10.2298/AVB0203181K .

Krstić, Nikola, Milosavljević, Željko, Tepavčević, Zvezdana, "Roentgencraniometric and roent-gencenphalometric determination of linear parameters on dogs of German Shepard breed" in Acta veterinaria, 52, no. 2-3 (2002):181-196,
https://doi.org/10.2298/AVB0203181K . .

TY  - JOUR
AU  - Krstić, Nikola
AU  - Macanović, Mirjana
AU  - Milosavljević, Željko
AU  - Tepavčević, Zvezdana
PY  - 2002
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1159
AB  - In parallel with the stepped up urbanisation of modern man, there is an increasing number of house pets of different breeds and species who suffer certain biological and physiological changes because of the specific manner of breeding and upkeep. The altered conditions of their natural environment can lead to disorders in the animal genetic fund, which is why numerous diseases include cases of constitutional flaws (caries, periodontosis and related complications, cysts, abscesses, malformations of hereditary origin - hypodontia, andontia, impacted teeth, and others). The paper presents cases of the most frequent diseases of teeth and supporting tissues, as well as the optimal manner of therapy. It also points out certain limitations in practicing veterinary orthodontia aimed at avoiding situations when certain congenital or acquired anomalies are corrected but result in the animal no longer meeting the required standards for its species.
AB  - Uporedo sa ubrzanom urbanizacijom modernog čoveka, zapaža se i povećan broj kućnih ljubimaca različitih vrsta i rasa, koji zbog specifičnog načina odgajanja trpe određene biološke i fiziološke promene. Izmenjeni uslovi prirodnog okruženja mogu da prouzrokuju poremećaje genetskog fonda životinja, što je razlog da se među mnogim bolestima javljaju slučajevi konstitucionalnih mana (karijes, paradontopatija i njihove komplikacije ciste, apscesi, malformacije naslednog porekla – hipodoncija, anodoncija impakcija zuba i slično). U radu su prikazani slučajevi najčešćih oboljenja zuba i njihovog potpornog aparata, kao i optimalni načini njihove terapije. Ukazano je i na određena ograničenja kojih moramo da se pridržavamo u veterinarskoj ortodonciji, kako bi se izbegle situacije korekcije pojedinih urođenih ili stečenih anomalija zbog kojih životinja odstupa od propisanih standarda za svoju vrstu.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Diagnosis and therapy of oral cavity diseases in small domestic animals
T1  - Dijagnostika i terapija oboljenja usne duplje malih domaćih životinja
VL  - 56
IS  - 3-4
SP  - 187
EP  - 194
DO  - 10.2298/VETGL0204187K
ER  - 

@article{
author = "Krstić, Nikola and Macanović, Mirjana and Milosavljević, Željko and Tepavčević, Zvezdana",
year = "2002",
abstract = "In parallel with the stepped up urbanisation of modern man, there is an increasing number of house pets of different breeds and species who suffer certain biological and physiological changes because of the specific manner of breeding and upkeep. The altered conditions of their natural environment can lead to disorders in the animal genetic fund, which is why numerous diseases include cases of constitutional flaws (caries, periodontosis and related complications, cysts, abscesses, malformations of hereditary origin - hypodontia, andontia, impacted teeth, and others). The paper presents cases of the most frequent diseases of teeth and supporting tissues, as well as the optimal manner of therapy. It also points out certain limitations in practicing veterinary orthodontia aimed at avoiding situations when certain congenital or acquired anomalies are corrected but result in the animal no longer meeting the required standards for its species., Uporedo sa ubrzanom urbanizacijom modernog čoveka, zapaža se i povećan broj kućnih ljubimaca različitih vrsta i rasa, koji zbog specifičnog načina odgajanja trpe određene biološke i fiziološke promene. Izmenjeni uslovi prirodnog okruženja mogu da prouzrokuju poremećaje genetskog fonda životinja, što je razlog da se među mnogim bolestima javljaju slučajevi konstitucionalnih mana (karijes, paradontopatija i njihove komplikacije ciste, apscesi, malformacije naslednog porekla – hipodoncija, anodoncija impakcija zuba i slično). U radu su prikazani slučajevi najčešćih oboljenja zuba i njihovog potpornog aparata, kao i optimalni načini njihove terapije. Ukazano je i na određena ograničenja kojih moramo da se pridržavamo u veterinarskoj ortodonciji, kako bi se izbegle situacije korekcije pojedinih urođenih ili stečenih anomalija zbog kojih životinja odstupa od propisanih standarda za svoju vrstu.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Diagnosis and therapy of oral cavity diseases in small domestic animals, Dijagnostika i terapija oboljenja usne duplje malih domaćih životinja",
volume = "56",
number = "3-4",
pages = "187-194",
doi = "10.2298/VETGL0204187K"
}

Krstić, N., Macanović, M., Milosavljević, Ž.,& Tepavčević, Z.. (2002). Diagnosis and therapy of oral cavity diseases in small domestic animals. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(3-4), 187-194.
https://doi.org/10.2298/VETGL0204187K

Krstić N, Macanović M, Milosavljević Ž, Tepavčević Z. Diagnosis and therapy of oral cavity diseases in small domestic animals. in Veterinarski glasnik. 2002;56(3-4):187-194.
doi:10.2298/VETGL0204187K .

Krstić, Nikola, Macanović, Mirjana, Milosavljević, Željko, Tepavčević, Zvezdana, "Diagnosis and therapy of oral cavity diseases in small domestic animals" in Veterinarski glasnik, 56, no. 3-4 (2002):187-194,
https://doi.org/10.2298/VETGL0204187K . .

TY  - THES
AU  - Tepavčević, Zvezdana
PY  - 1997
UR  - https://plus.sr.cobiss.net/opac7/bib/1024065166
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/326
PB  - Univerzitet u Beogradu, Stomatološki fakultet
T1  - Kliničko-patohistološki aspekti odontogenih keratocista sa posebnim osvrtom na satelitske formacije i mogućnosti recidiviranja
UR  - https://hdl.handle.net/21.15107/rcub_smile_326
ER  - 

@mastersthesis{
author = "Tepavčević, Zvezdana",
year = "1997",
publisher = "Univerzitet u Beogradu, Stomatološki fakultet",
title = "Kliničko-patohistološki aspekti odontogenih keratocista sa posebnim osvrtom na satelitske formacije i mogućnosti recidiviranja",
url = "https://hdl.handle.net/21.15107/rcub_smile_326"
}

Tepavčević, Z.. (1997). Kliničko-patohistološki aspekti odontogenih keratocista sa posebnim osvrtom na satelitske formacije i mogućnosti recidiviranja. 
Univerzitet u Beogradu, Stomatološki fakultet..
https://hdl.handle.net/21.15107/rcub_smile_326

Tepavčević Z. Kliničko-patohistološki aspekti odontogenih keratocista sa posebnim osvrtom na satelitske formacije i mogućnosti recidiviranja. 1997;.
https://hdl.handle.net/21.15107/rcub_smile_326 .

Tepavčević, Zvezdana, "Kliničko-patohistološki aspekti odontogenih keratocista sa posebnim osvrtom na satelitske formacije i mogućnosti recidiviranja" (1997),
https://hdl.handle.net/21.15107/rcub_smile_326 .