Radunović, Milena

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Authority KeyName Variants
orcid::0000-0003-3507-1186
  • Radunović, Milena (21)
Projects
Cellular and molecular basis of malignant and cardiovascular diseases-clinical implications Interraction of etiopathogenetic mechanisms of periodontal disease and periimplantitis with the systemic disorders of the present day
Detection of early laboratory fungal biomarkers and it's importance for outcome of invasive fungal infections in Serbia Light microscopy, electron microscopy, immunomorphologic, molecular biology and genetic investigations of malignant and nonmalignant renal diseases.
Genetic control and molecular mechanisms in malignant, inflammatory and developmental pathologies of the orofacial region Neuroendocrine control of growth hormone secretion in humans - new challenges. Control of energy homeostasis in humans in various pathological conditions. Genetics in familial pituitary tumorigenesis. Clinical-pathological correlations in atypical pituit
Italian Ministry of Education, University and Research (MIUR)Ministry of Education, Universities and Research (MIUR) [20102ZLNJ5] MIUR FIRB-Accordi di Programma ProjectMinistry of Education, Universities and Research (MIUR)
MIUR FIRB-Accordi di Programma Project Processi degenerativi dei tessuti mineralizzati del cavo orale, impiego di biomateriali e controllo delle interazioni con i microrganismi dell'ambiente', CARICHIETI MIUR (FIRB)Ministry of Education, Universities and Research (MIUR)Fund for Investment in Basic Research (FIRB) [RBAP1095CR]
MIUR (PRIN)Ministry of Education, Universities and Research (MIUR)Research Projects of National Relevance (PRIN) [2010N3T9M4] PO FSE Abruzzo - Progetto "Innovazione, Sviluppo e Competitivita"
PO FSE Abruzzo -Progetto "Innovazione, Sviluppo e Competitivita" Reti per l'alta formazione
Universities of Chieti-Pescara

Author's Bibliography

Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections

Radunović, Milena; Petrini, M.; Vlajić, T.; Iezzi, G.; Di Lodovico, S.; Piattelli, Adriano; D'Ercole, S.

(Elsevier Science Sa, Lausanne, 2020)

TY  - JOUR
AU  - Radunović, Milena
AU  - Petrini, M.
AU  - Vlajić, T.
AU  - Iezzi, G.
AU  - Di Lodovico, S.
AU  - Piattelli, Adriano
AU  - D'Ercole, S.
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2509
AB  - Antibiotic resistance is a major public health problem worldwide and the finding of alternative methods for eliminating bacteria is one of the prerogatives of medical research. The indiscriminate use of antibiotics in dentistry, especially for the treatment of peri-implantitis, could lead to superinfections. Alternative methods, like photodynamic therapy mediated by the use of aminolevulinic acid and a red light has been largely described, especially in dentistry, but results were encouraging against Gram-positive bacteria, but limited against Gram-negative. The effectiveness of photodynamic therapy mediated by a novel product containing aminolevulinic acid, Aladent (ALAD) has been tested in this in vitro study, against different types of bacteria particularly involved in the infections of the oral cavity and peri-implantitis. The novelty of ALAD is the marked hydrophilicity that should increase the passage of the molecule through the membrane pores of Gram-negative bacteria. Considering the novelty of the product a preliminary experiment permitted to test the effectiveness against Enterococcus faecalis after 1 h of ALAD incubation at different concentrations, with or without different timings of LED irradiation. The count of CFUs and the live/dead observation with fluorescent microscopy showed a significant reduction and killing of bacterium. Then, in the second stage, that could meet the necessity of effectiveness and the clinician's requests to reduce the timing of treatment, ALAD, with and without irradiation, was tested on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Veillonella parvula and Porphyromonas gingivalis. In particular, the efficiency of different concentrations of the product after a 25 min incubation was tested with and without the adjunctive LED irradiation for 5 min. A slight ALAD bactericidal effect was reported for all bacteria, also without LED irradiation, however, the most effective treatment was 25 min of 50% ALAD incubation followed by 5 min of a red LED. The in vitro tests demonstrated that ALAD gel with LED irradiation exerts a potent antibacterial activity on different bacteria, both Gram-positive and Gram-negative.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Photochemistry & Photobiology B-Biology
T1  - Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections
VL  - 205
DO  - 10.1016/j.jphotobiol.2020.111826
ER  - 
@article{
author = "Radunović, Milena and Petrini, M. and Vlajić, T. and Iezzi, G. and Di Lodovico, S. and Piattelli, Adriano and D'Ercole, S.",
year = "2020",
abstract = "Antibiotic resistance is a major public health problem worldwide and the finding of alternative methods for eliminating bacteria is one of the prerogatives of medical research. The indiscriminate use of antibiotics in dentistry, especially for the treatment of peri-implantitis, could lead to superinfections. Alternative methods, like photodynamic therapy mediated by the use of aminolevulinic acid and a red light has been largely described, especially in dentistry, but results were encouraging against Gram-positive bacteria, but limited against Gram-negative. The effectiveness of photodynamic therapy mediated by a novel product containing aminolevulinic acid, Aladent (ALAD) has been tested in this in vitro study, against different types of bacteria particularly involved in the infections of the oral cavity and peri-implantitis. The novelty of ALAD is the marked hydrophilicity that should increase the passage of the molecule through the membrane pores of Gram-negative bacteria. Considering the novelty of the product a preliminary experiment permitted to test the effectiveness against Enterococcus faecalis after 1 h of ALAD incubation at different concentrations, with or without different timings of LED irradiation. The count of CFUs and the live/dead observation with fluorescent microscopy showed a significant reduction and killing of bacterium. Then, in the second stage, that could meet the necessity of effectiveness and the clinician's requests to reduce the timing of treatment, ALAD, with and without irradiation, was tested on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Veillonella parvula and Porphyromonas gingivalis. In particular, the efficiency of different concentrations of the product after a 25 min incubation was tested with and without the adjunctive LED irradiation for 5 min. A slight ALAD bactericidal effect was reported for all bacteria, also without LED irradiation, however, the most effective treatment was 25 min of 50% ALAD incubation followed by 5 min of a red LED. The in vitro tests demonstrated that ALAD gel with LED irradiation exerts a potent antibacterial activity on different bacteria, both Gram-positive and Gram-negative.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Photochemistry & Photobiology B-Biology",
title = "Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections",
volume = "205",
doi = "10.1016/j.jphotobiol.2020.111826"
}
Radunović, M., Petrini, M., Vlajić, T., Iezzi, G., Di Lodovico, S., Piattelli, A.,& D'Ercole, S.. (2020). Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections. in Journal of Photochemistry & Photobiology B-Biology
Elsevier Science Sa, Lausanne., 205.
https://doi.org/10.1016/j.jphotobiol.2020.111826
Radunović M, Petrini M, Vlajić T, Iezzi G, Di Lodovico S, Piattelli A, D'Ercole S. Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections. in Journal of Photochemistry & Photobiology B-Biology. 2020;205.
doi:10.1016/j.jphotobiol.2020.111826 .
Radunović, Milena, Petrini, M., Vlajić, T., Iezzi, G., Di Lodovico, S., Piattelli, Adriano, D'Ercole, S., "Effects of a novel gel containing 5-aminolevulinic acid and red LED against bacteria involved in peri-implantitis and other oral infections" in Journal of Photochemistry & Photobiology B-Biology, 205 (2020),
https://doi.org/10.1016/j.jphotobiol.2020.111826 . .
1
31
17
35

Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects

Matić-Petrović, Sanja; Radunović, Milena; Barać, Milena; Kuzmanović-Pfićer, Jovana; Pavlica, Dušan; Arsić-Arsenijević, Valentina; Pucar, Ana

(Public Library Science, San Francisco, 2019)

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Radunović, Milena
AU  - Barać, Milena
AU  - Kuzmanović-Pfićer, Jovana
AU  - Pavlica, Dušan
AU  - Arsić-Arsenijević, Valentina
AU  - Pucar, Ana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2463
AB  - Objectives The aim of this cross-sectional observational study was to compare the prevalence of different oral Candida spp. in patients with Type 2 Diabetes and chronic periodontitis in two oral sites: dorsal surface of the tongue and subgingival area. In order to determine subgingival areas as potential reservoirs of yeasts, this study aimed to find differences in the yeasts' detection between the dorsum of the tongue, as the oral site most commonly inhabited with microorganisms, and subgingival samples. Additionally, potential predictors for the yeasts prevalence were determined. Material and methods Subjects (N = 146) were divided into four groups: group A-healthy individuals without periodontitis, group B-healthy individuals with chronic periodontitis, group C-Type 2 Diabetes patients with good glycoregulation and Chronic periodontitis and group D-Type 2 Diabetes patients with poor glycoregulation and Chronic periodontitis. Samples were obtained from the tongue by swabbing. Subgingival plaque samples were taken by paper points and periodontal curette. Isolation and identification of different Candida spp. was done using ChromAgar medium. In addition, germ-tube production and carbohydrate assimilation tests were performed. Results The prevalence of Candida spp. was higher in diabetics with poor glycoregulation. The most frequently isolated species was Candida albicans followed by Candida glabrata and Candida tropicalis. In 15.6% of cases, Candida spp. was present in the subgingival area while absent on the tongue. Multivariate regression model showed that HbA1c was Candida spp. predictor for both locations. Conclusions Our results confirmed that there are Candida spp. carriers among subjects with clinically healthy oral mucosa. Also, this study identified subgingival areas as potential reservoirs of these pathogenic species. Glycoregulation has been recognized as a positive predictor factor of Candida spp.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects
VL  - 14
IS  - 1
DO  - 10.1371/journal.pone.0210527
ER  - 
@article{
author = "Matić-Petrović, Sanja and Radunović, Milena and Barać, Milena and Kuzmanović-Pfićer, Jovana and Pavlica, Dušan and Arsić-Arsenijević, Valentina and Pucar, Ana",
year = "2019",
abstract = "Objectives The aim of this cross-sectional observational study was to compare the prevalence of different oral Candida spp. in patients with Type 2 Diabetes and chronic periodontitis in two oral sites: dorsal surface of the tongue and subgingival area. In order to determine subgingival areas as potential reservoirs of yeasts, this study aimed to find differences in the yeasts' detection between the dorsum of the tongue, as the oral site most commonly inhabited with microorganisms, and subgingival samples. Additionally, potential predictors for the yeasts prevalence were determined. Material and methods Subjects (N = 146) were divided into four groups: group A-healthy individuals without periodontitis, group B-healthy individuals with chronic periodontitis, group C-Type 2 Diabetes patients with good glycoregulation and Chronic periodontitis and group D-Type 2 Diabetes patients with poor glycoregulation and Chronic periodontitis. Samples were obtained from the tongue by swabbing. Subgingival plaque samples were taken by paper points and periodontal curette. Isolation and identification of different Candida spp. was done using ChromAgar medium. In addition, germ-tube production and carbohydrate assimilation tests were performed. Results The prevalence of Candida spp. was higher in diabetics with poor glycoregulation. The most frequently isolated species was Candida albicans followed by Candida glabrata and Candida tropicalis. In 15.6% of cases, Candida spp. was present in the subgingival area while absent on the tongue. Multivariate regression model showed that HbA1c was Candida spp. predictor for both locations. Conclusions Our results confirmed that there are Candida spp. carriers among subjects with clinically healthy oral mucosa. Also, this study identified subgingival areas as potential reservoirs of these pathogenic species. Glycoregulation has been recognized as a positive predictor factor of Candida spp.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects",
volume = "14",
number = "1",
doi = "10.1371/journal.pone.0210527"
}
Matić-Petrović, S., Radunović, M., Barać, M., Kuzmanović-Pfićer, J., Pavlica, D., Arsić-Arsenijević, V.,& Pucar, A.. (2019). Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects. in PLoS One
Public Library Science, San Francisco., 14(1).
https://doi.org/10.1371/journal.pone.0210527
Matić-Petrović S, Radunović M, Barać M, Kuzmanović-Pfićer J, Pavlica D, Arsić-Arsenijević V, Pucar A. Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects. in PLoS One. 2019;14(1).
doi:10.1371/journal.pone.0210527 .
Matić-Petrović, Sanja, Radunović, Milena, Barać, Milena, Kuzmanović-Pfićer, Jovana, Pavlica, Dušan, Arsić-Arsenijević, Valentina, Pucar, Ana, "Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects" in PLoS One, 14, no. 1 (2019),
https://doi.org/10.1371/journal.pone.0210527 . .
1
25
7
21

Geographic tongue: Does Candida play a role in its pathogenesis

Matić-Petrović, Sanja; Đorđević, Mihajlo; Radunović, Milena; Živanović, Tanja; Pavlica, Dušan; Pucar, Ana

(Udruženje stomatologa Balkana, 2019)

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Đorđević, Mihajlo
AU  - Radunović, Milena
AU  - Živanović, Tanja
AU  - Pavlica, Dušan
AU  - Pucar, Ana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2406
AB  - Background/Aim: Geographic tongue (GT), a benign self-limiting condition (inflammation) is commonly seen in practice. Although quite easy for clinical diagnosis, in clinical practice it is commonly misdiagnosed and treated as Candida infection. The main aim of this study was to compare the prevalence of Candida spp. on tongue in patients with GT and subjects with clinically healthy oral mucosa. Additional aims were to evaluate subjective symptoms, uncontrolled usage of prescribed or non-prescribed antifungal topical medications and the presence of the cancerophobia or other health concerns in patients with GT. Material and Methods: A total of 70 subjects were divided into two groups: Group B - patients with diagnosed Geographic tongue and group A - aged and gender matched controls with clinically health oral mucosa. Anamnestic charts designed for this study included information about symptoms (measured by Visual Analogue Scale), previous knowledge or fear about presence of GT and received therapy for this condition. Detection of Candida spp. from tongue was done using sterile cotton swab and Sabouraud dextrose agar. Results: At the time of this study, 18 (52.94%) of subjects with GT were aware of having this condition and even 12 of them (66.7%) used topical antifungal drugs prescribed by physician. Also, 66.7% of them experienced fear about the presence of GT at some moment. Detection of Candida spp. was similarly distributed in both groups (22.2% in group A and 17.6% in group B). Conclusions: Geographic tongue has frequently been treated by topical antifungal drugs. In this study, GT was not associated with presence of Candida spp.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Geographic tongue: Does Candida play a role in its pathogenesis
VL  - 23
IS  - 3
SP  - 152
EP  - 156
DO  - 10.2478/bjdm-2019-0027
ER  - 
@article{
author = "Matić-Petrović, Sanja and Đorđević, Mihajlo and Radunović, Milena and Živanović, Tanja and Pavlica, Dušan and Pucar, Ana",
year = "2019",
abstract = "Background/Aim: Geographic tongue (GT), a benign self-limiting condition (inflammation) is commonly seen in practice. Although quite easy for clinical diagnosis, in clinical practice it is commonly misdiagnosed and treated as Candida infection. The main aim of this study was to compare the prevalence of Candida spp. on tongue in patients with GT and subjects with clinically healthy oral mucosa. Additional aims were to evaluate subjective symptoms, uncontrolled usage of prescribed or non-prescribed antifungal topical medications and the presence of the cancerophobia or other health concerns in patients with GT. Material and Methods: A total of 70 subjects were divided into two groups: Group B - patients with diagnosed Geographic tongue and group A - aged and gender matched controls with clinically health oral mucosa. Anamnestic charts designed for this study included information about symptoms (measured by Visual Analogue Scale), previous knowledge or fear about presence of GT and received therapy for this condition. Detection of Candida spp. from tongue was done using sterile cotton swab and Sabouraud dextrose agar. Results: At the time of this study, 18 (52.94%) of subjects with GT were aware of having this condition and even 12 of them (66.7%) used topical antifungal drugs prescribed by physician. Also, 66.7% of them experienced fear about the presence of GT at some moment. Detection of Candida spp. was similarly distributed in both groups (22.2% in group A and 17.6% in group B). Conclusions: Geographic tongue has frequently been treated by topical antifungal drugs. In this study, GT was not associated with presence of Candida spp.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Geographic tongue: Does Candida play a role in its pathogenesis",
volume = "23",
number = "3",
pages = "152-156",
doi = "10.2478/bjdm-2019-0027"
}
Matić-Petrović, S., Đorđević, M., Radunović, M., Živanović, T., Pavlica, D.,& Pucar, A.. (2019). Geographic tongue: Does Candida play a role in its pathogenesis. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 23(3), 152-156.
https://doi.org/10.2478/bjdm-2019-0027
Matić-Petrović S, Đorđević M, Radunović M, Živanović T, Pavlica D, Pucar A. Geographic tongue: Does Candida play a role in its pathogenesis. in Balkan Journal of Dental Medicine. 2019;23(3):152-156.
doi:10.2478/bjdm-2019-0027 .
Matić-Petrović, Sanja, Đorđević, Mihajlo, Radunović, Milena, Živanović, Tanja, Pavlica, Dušan, Pucar, Ana, "Geographic tongue: Does Candida play a role in its pathogenesis" in Balkan Journal of Dental Medicine, 23, no. 3 (2019):152-156,
https://doi.org/10.2478/bjdm-2019-0027 . .
2

Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis

Perić, Mirjana; Radunović, Milena; Pekmezović, Marina; Marinković, Jelena; Živković, Rade; Arsić-Arsenijević, Valentina

(Wiley, Hoboken, 2019)

TY  - JOUR
AU  - Perić, Mirjana
AU  - Radunović, Milena
AU  - Pekmezović, Marina
AU  - Marinković, Jelena
AU  - Živković, Rade
AU  - Arsić-Arsenijević, Valentina
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2379
AB  - Purpose Denture stomatitis (DS) is a disease characterized by inflammation and erythema of the oral mucosa areas covered by the denture. Multifactorial etiological factors contribute to DS, but it seems that Candida plays the key role. The aim of the study was to evaluate the denture sonication method to: (i) increase the possibility of diagnosing patients with Candida-associated DS; (ii) detect and identify the mixed Candida spp., and (iii) determine the Candida colony forming units (CFU) and its possible relationship with DS severity, based on Newton's classification. Materials and Methods The cross-sectional study conducted at the Clinic for Dental Prosthetics, Belgrade (Serbia) from June 2013 to December 2014 enrolled edentulous patients with dentures (n = 250). Patients without DS (n = 20) were the control group (CG). The patients' data were collected, and patients with DS (study group/SG) were selected and divided into SG Candida+ and SG Candida-. Based on severity of DS, the SG patients were classified in 3 groups (Newton's classification). Four sampling methods were applied to detect patients with Candida-associated DS: mucosa swab, denture swab, oral rinse, and denture sonication method. The sensitivity and specificity of denture sonication method were shown using the receiver operating characteristic (ROC) curve and the area under the curve (AUC). Results In 97 (38.8%), out of 250 clinically examined patients, DS was diagnosed. In 82 (84.5%), out of 97 mycologically examined patients, Candida-associated DS was detected when denture sonication method was applied. Additionally, using the denture sonication method we observed: (i) the largest number of Candida positive patients compared to other sampling methods (p  lt  0.0001); (ii) the highest number of Candida CFU/ml (10(5)), and (iii) the possibility to detect mixed Candida cultures. The largest number of patients with Candida-associated DS showed type II (60%) DS, followed by type I (21%), and type III (19%) DS. Conclusion The denture sonication method is easy, accurate, and sensitive, and increases the possibility of diagnosing patients with Candida-associated DS. Additionally, yeast quantification, mixed Candida spp., and non-albicans Candida were detectable when cultivation on Candida CHROMagar was performed. It was not possible using conventional methods, such as swab or oral rinse.
PB  - Wiley, Hoboken
T2  - Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry
T1  - Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis
VL  - 28
IS  - 5
SP  - 580
EP  - 586
DO  - 10.1111/jopr.12610
ER  - 
@article{
author = "Perić, Mirjana and Radunović, Milena and Pekmezović, Marina and Marinković, Jelena and Živković, Rade and Arsić-Arsenijević, Valentina",
year = "2019",
abstract = "Purpose Denture stomatitis (DS) is a disease characterized by inflammation and erythema of the oral mucosa areas covered by the denture. Multifactorial etiological factors contribute to DS, but it seems that Candida plays the key role. The aim of the study was to evaluate the denture sonication method to: (i) increase the possibility of diagnosing patients with Candida-associated DS; (ii) detect and identify the mixed Candida spp., and (iii) determine the Candida colony forming units (CFU) and its possible relationship with DS severity, based on Newton's classification. Materials and Methods The cross-sectional study conducted at the Clinic for Dental Prosthetics, Belgrade (Serbia) from June 2013 to December 2014 enrolled edentulous patients with dentures (n = 250). Patients without DS (n = 20) were the control group (CG). The patients' data were collected, and patients with DS (study group/SG) were selected and divided into SG Candida+ and SG Candida-. Based on severity of DS, the SG patients were classified in 3 groups (Newton's classification). Four sampling methods were applied to detect patients with Candida-associated DS: mucosa swab, denture swab, oral rinse, and denture sonication method. The sensitivity and specificity of denture sonication method were shown using the receiver operating characteristic (ROC) curve and the area under the curve (AUC). Results In 97 (38.8%), out of 250 clinically examined patients, DS was diagnosed. In 82 (84.5%), out of 97 mycologically examined patients, Candida-associated DS was detected when denture sonication method was applied. Additionally, using the denture sonication method we observed: (i) the largest number of Candida positive patients compared to other sampling methods (p  lt  0.0001); (ii) the highest number of Candida CFU/ml (10(5)), and (iii) the possibility to detect mixed Candida cultures. The largest number of patients with Candida-associated DS showed type II (60%) DS, followed by type I (21%), and type III (19%) DS. Conclusion The denture sonication method is easy, accurate, and sensitive, and increases the possibility of diagnosing patients with Candida-associated DS. Additionally, yeast quantification, mixed Candida spp., and non-albicans Candida were detectable when cultivation on Candida CHROMagar was performed. It was not possible using conventional methods, such as swab or oral rinse.",
publisher = "Wiley, Hoboken",
journal = "Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry",
title = "Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis",
volume = "28",
number = "5",
pages = "580-586",
doi = "10.1111/jopr.12610"
}
Perić, M., Radunović, M., Pekmezović, M., Marinković, J., Živković, R.,& Arsić-Arsenijević, V.. (2019). Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis. in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry
Wiley, Hoboken., 28(5), 580-586.
https://doi.org/10.1111/jopr.12610
Perić M, Radunović M, Pekmezović M, Marinković J, Živković R, Arsić-Arsenijević V. Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis. in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry. 2019;28(5):580-586.
doi:10.1111/jopr.12610 .
Perić, Mirjana, Radunović, Milena, Pekmezović, Marina, Marinković, Jelena, Živković, Rade, Arsić-Arsenijević, Valentina, "Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis" in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry, 28, no. 5 (2019):580-586,
https://doi.org/10.1111/jopr.12610 . .
9
2
9

P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population

Nikolić, Nadja; Čarkić, Jelena; Ilic-Dimitrijević, Ivana; Eljabo, Najib; Radunović, Milena; Aničić, Boban; Tanić, Nasta; Falk, Markus; Milašin, Jelena

(Elsevier Science Inc, New York, 2018)

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Ilic-Dimitrijević, Ivana
AU  - Eljabo, Najib
AU  - Radunović, Milena
AU  - Aničić, Boban
AU  - Tanić, Nasta
AU  - Falk, Markus
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2317
AB  - Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. Study design. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. Results. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P  lt  .001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P  lt  .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Conclusions. Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modest impact on clinical parameters.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population
VL  - 125
IS  - 1
SP  - 52
EP  - 58
DO  - 10.1016/j.oooo.2017.09.013
ER  - 
@article{
author = "Nikolić, Nadja and Čarkić, Jelena and Ilic-Dimitrijević, Ivana and Eljabo, Najib and Radunović, Milena and Aničić, Boban and Tanić, Nasta and Falk, Markus and Milašin, Jelena",
year = "2018",
abstract = "Objective. To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. Study design. DNA extracted from 35 formalin-fixed and paraffin-embedded MEC samples and 10 normal salivary gland (NSG) tissue samples was analyzed for the presence of promoter hypermethylation using methylation-specific polymerase chain reaction testing. Results. The percentages of gene hypermethylation in MECs versus NSGs were the following: p14: 100% versus 20% (P  lt  .001); p16: 60% versus 20% (P = .035); hTERT: 54.3% versus 20% (P = .078); and TP53: 31.4% versus 30% (P = .981). Multiple sites were found to be methylated in 86% of MECs compared with 10% in NSGs (P  lt  .001). TP53 and hTERT were more often methylated in lower clinical stages (P = .033 and P = .005, respectively). Conclusions. Hypermethylation of p14 appears to be an important event in the development of mucoepidermoid carcinoma. High frequency of gene hypermethylation and high incidence of methylation at multiple sites point to the importance of epigenetic phenomena in the pathogenesis of MECs, although with modest impact on clinical parameters.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population",
volume = "125",
number = "1",
pages = "52-58",
doi = "10.1016/j.oooo.2017.09.013"
}
Nikolić, N., Čarkić, J., Ilic-Dimitrijević, I., Eljabo, N., Radunović, M., Aničić, B., Tanić, N., Falk, M.,& Milašin, J.. (2018). P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 125(1), 52-58.
https://doi.org/10.1016/j.oooo.2017.09.013
Nikolić N, Čarkić J, Ilic-Dimitrijević I, Eljabo N, Radunović M, Aničić B, Tanić N, Falk M, Milašin J. P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2018;125(1):52-58.
doi:10.1016/j.oooo.2017.09.013 .
Nikolić, Nadja, Čarkić, Jelena, Ilic-Dimitrijević, Ivana, Eljabo, Najib, Radunović, Milena, Aničić, Boban, Tanić, Nasta, Falk, Markus, Milašin, Jelena, "P14 methylation: an epigenetic signature of salivary gland mucoepidermoid carcinoma in the Serbian population" in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 125, no. 1 (2018):52-58,
https://doi.org/10.1016/j.oooo.2017.09.013 . .
2
11
6
11

The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques- An age related comparative analysis

Kannosh, Ibrahim; Staletović, Danijela; Toljić, Boško; Radunović, Milena; Pucar, Ana; Matić-Petrović, Sanja; Grubiša, Ivana; Lazarević, Miloš; Brkić, Zlata; Knežević-Vukcević, Jelena; Milašin, Jelena

(J Infection Developing Countries, Tramaniglio, 2018)

TY  - JOUR
AU  - Kannosh, Ibrahim
AU  - Staletović, Danijela
AU  - Toljić, Boško
AU  - Radunović, Milena
AU  - Pucar, Ana
AU  - Matić-Petrović, Sanja
AU  - Grubiša, Ivana
AU  - Lazarević, Miloš
AU  - Brkić, Zlata
AU  - Knežević-Vukcević, Jelena
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2276
AB  - Introduction: There is a known connection between periodontitis and atherosclerosis and the presence of periopathogens in blood vessels. However, changes of the oral microflora related to the aging process and its possible effects on atherosclerosis, have yet to be analyzed. The aim of this study was to assess temporal changes in the frequency of periodontal bacteria in the subgingival plaque and in atherosclerotic blood vessels of patients with atherosclerosis. Methodology: The study included 100 patients with atherosclerosis and periodontitis, divided into two groups, below and over 60 years of age. Clinical examinations were performedand subgingival plaque specimens were collected as well as biopsy specimens from the following arteries: coronary (34), carotid (29), abdominal (10), femoral (10), mammary (13) and iliac (4). Subgingival and artery specimens were subjected to PCR detection of 5 major periodontal pathogens: Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythensis (Tf) and Treponema denticola (Td). Results: Tf was the most and Td the least frequent bacteria in both age groups and in both types of samples. The frequencies of bacteria in subgingival versus atherosclerotic samples were: Tf (76%: 53%), Pi (71%: 31%), Pg (60%: 38%), Aa (39%: 14%) and Td (21%: 6%). Only Aa and Pi showed a significant difference of prevalence between younger and older patients. The most colonized artery was a. coronaria, followed by a. carotis, a. abdominalis, a. mammaria, and a. femoralis. Conclusions: Patient's age and the distance of a given blood vessel from the oral cavity influenced microbiological findings in the atherotic plaque.
PB  - J Infection Developing Countries, Tramaniglio
T2  - Journal of Infection in Developing Countries
T1  - The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques- An age related comparative analysis
VL  - 12
IS  - 12
SP  - 1088
EP  - 1095
DO  - 10.3855/jidc.10980
ER  - 
@article{
author = "Kannosh, Ibrahim and Staletović, Danijela and Toljić, Boško and Radunović, Milena and Pucar, Ana and Matić-Petrović, Sanja and Grubiša, Ivana and Lazarević, Miloš and Brkić, Zlata and Knežević-Vukcević, Jelena and Milašin, Jelena",
year = "2018",
abstract = "Introduction: There is a known connection between periodontitis and atherosclerosis and the presence of periopathogens in blood vessels. However, changes of the oral microflora related to the aging process and its possible effects on atherosclerosis, have yet to be analyzed. The aim of this study was to assess temporal changes in the frequency of periodontal bacteria in the subgingival plaque and in atherosclerotic blood vessels of patients with atherosclerosis. Methodology: The study included 100 patients with atherosclerosis and periodontitis, divided into two groups, below and over 60 years of age. Clinical examinations were performedand subgingival plaque specimens were collected as well as biopsy specimens from the following arteries: coronary (34), carotid (29), abdominal (10), femoral (10), mammary (13) and iliac (4). Subgingival and artery specimens were subjected to PCR detection of 5 major periodontal pathogens: Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythensis (Tf) and Treponema denticola (Td). Results: Tf was the most and Td the least frequent bacteria in both age groups and in both types of samples. The frequencies of bacteria in subgingival versus atherosclerotic samples were: Tf (76%: 53%), Pi (71%: 31%), Pg (60%: 38%), Aa (39%: 14%) and Td (21%: 6%). Only Aa and Pi showed a significant difference of prevalence between younger and older patients. The most colonized artery was a. coronaria, followed by a. carotis, a. abdominalis, a. mammaria, and a. femoralis. Conclusions: Patient's age and the distance of a given blood vessel from the oral cavity influenced microbiological findings in the atherotic plaque.",
publisher = "J Infection Developing Countries, Tramaniglio",
journal = "Journal of Infection in Developing Countries",
title = "The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques- An age related comparative analysis",
volume = "12",
number = "12",
pages = "1088-1095",
doi = "10.3855/jidc.10980"
}
Kannosh, I., Staletović, D., Toljić, B., Radunović, M., Pucar, A., Matić-Petrović, S., Grubiša, I., Lazarević, M., Brkić, Z., Knežević-Vukcević, J.,& Milašin, J.. (2018). The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques- An age related comparative analysis. in Journal of Infection in Developing Countries
J Infection Developing Countries, Tramaniglio., 12(12), 1088-1095.
https://doi.org/10.3855/jidc.10980
Kannosh I, Staletović D, Toljić B, Radunović M, Pucar A, Matić-Petrović S, Grubiša I, Lazarević M, Brkić Z, Knežević-Vukcević J, Milašin J. The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques- An age related comparative analysis. in Journal of Infection in Developing Countries. 2018;12(12):1088-1095.
doi:10.3855/jidc.10980 .
Kannosh, Ibrahim, Staletović, Danijela, Toljić, Boško, Radunović, Milena, Pucar, Ana, Matić-Petrović, Sanja, Grubiša, Ivana, Lazarević, Miloš, Brkić, Zlata, Knežević-Vukcević, Jelena, Milašin, Jelena, "The presence of periopathogenic bacteria in subgingival and atherosclerotic plaques- An age related comparative analysis" in Journal of Infection in Developing Countries, 12, no. 12 (2018):1088-1095,
https://doi.org/10.3855/jidc.10980 . .
1
12
6
12

Subgingival sites and oral cavity as reservoirs for Candida spp. in diabetics and non-diabetics

Radunović, Milena; Matić-Petrović, Sanja; Cimbaljević, Milena; Kuzmanović-Pfićer, Jovana; Pavlica, Dušan; Arsić-Arsenijević, Valentina; Pucar, Ana

(Oxford Univ Press, Oxford, 2018)

TY  - CONF
AU  - Radunović, Milena
AU  - Matić-Petrović, Sanja
AU  - Cimbaljević, Milena
AU  - Kuzmanović-Pfićer, Jovana
AU  - Pavlica, Dušan
AU  - Arsić-Arsenijević, Valentina
AU  - Pucar, Ana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2295
PB  - Oxford Univ Press, Oxford
C3  - Medical Mycology
T1  - Subgingival sites and oral cavity as reservoirs for Candida spp. in diabetics and non-diabetics
VL  - 56
SP  - S108
EP  - S108
UR  - https://hdl.handle.net/21.15107/rcub_smile_2295
ER  - 
@conference{
author = "Radunović, Milena and Matić-Petrović, Sanja and Cimbaljević, Milena and Kuzmanović-Pfićer, Jovana and Pavlica, Dušan and Arsić-Arsenijević, Valentina and Pucar, Ana",
year = "2018",
publisher = "Oxford Univ Press, Oxford",
journal = "Medical Mycology",
title = "Subgingival sites and oral cavity as reservoirs for Candida spp. in diabetics and non-diabetics",
volume = "56",
pages = "S108-S108",
url = "https://hdl.handle.net/21.15107/rcub_smile_2295"
}
Radunović, M., Matić-Petrović, S., Cimbaljević, M., Kuzmanović-Pfićer, J., Pavlica, D., Arsić-Arsenijević, V.,& Pucar, A.. (2018). Subgingival sites and oral cavity as reservoirs for Candida spp. in diabetics and non-diabetics. in Medical Mycology
Oxford Univ Press, Oxford., 56, S108-S108.
https://hdl.handle.net/21.15107/rcub_smile_2295
Radunović M, Matić-Petrović S, Cimbaljević M, Kuzmanović-Pfićer J, Pavlica D, Arsić-Arsenijević V, Pucar A. Subgingival sites and oral cavity as reservoirs for Candida spp. in diabetics and non-diabetics. in Medical Mycology. 2018;56:S108-S108.
https://hdl.handle.net/21.15107/rcub_smile_2295 .
Radunović, Milena, Matić-Petrović, Sanja, Cimbaljević, Milena, Kuzmanović-Pfićer, Jovana, Pavlica, Dušan, Arsić-Arsenijević, Valentina, Pucar, Ana, "Subgingival sites and oral cavity as reservoirs for Candida spp. in diabetics and non-diabetics" in Medical Mycology, 56 (2018):S108-S108,
https://hdl.handle.net/21.15107/rcub_smile_2295 .

Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study

Matić-Petrović, Sanja; Barać, Milena; Kuzmanović-Pfićer, Jovana; Radunović, Milena; Jotić, Aleksandra; Pucar, Ana

(Udruženje stomatologa Balkana, 2018)

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Barać, Milena
AU  - Kuzmanović-Pfićer, Jovana
AU  - Radunović, Milena
AU  - Jotić, Aleksandra
AU  - Pucar, Ana
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2365
AB  - Background/Aim: The aim of this study was to examine prevalence of different Candida spp. at diabetics and nondiabetics wearing dentures without clinical signs of Denture Stomatitis (DS) and to study if some local and systematic factors are confounders for harboring Candida at these subjects. Material and Methods: Total of 60 subjects wearing partial or complete upper acrylic denture having at least half of palatal mucosa covered by denture were selected and stratified into three experimental groups: systematically health subjects; patients with diagnosed Type 2 Diabetes (T2D) and good glycoregulation; and T2D subjects with poorly regulated blood sugar level. Cotton swab samples were obtained from each patient from hard palate mucosa and denture surface. Swab cultures were made on Sabouraud dextrose agar and ChromAgar Media for distinciton of various Candida spp. Density growth was also measured. Results: Frequency of Candida spp. findings were similar between groups. At healthy subjects, only C.albicans was detected. At diabetics, C.albicans was the most common isolated species, followed by C.glabrata and C.tropicalis. Negative finding of yeasts on palatal mucosa, but positive on denture surface were detected at all groups, with the highest frequency (33.4%) at diabetics with poor glycoregulation. Denture surface was heavier colonized than hard palate mucosa. Duration of diabetes in years were only independent predictors for harboring Candida spp. at denture surface (Exp B=1.186, CI=1.047-1.344, p=0.007). Conclusions: Prosthesis of denture wearers without DS may serve as reservoir of Candida spp. Presence of more pathogenic and resistant non-albicans species are related to diabetics, even without clinical signs of DS.
PB  - Udruženje stomatologa Balkana
T2  - Balkan Journal of Dental Medicine
T1  - Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study
VL  - 22
IS  - 1
SP  - 15
EP  - 21
DO  - 10.2478/bjdm-2018-0003
ER  - 
@article{
author = "Matić-Petrović, Sanja and Barać, Milena and Kuzmanović-Pfićer, Jovana and Radunović, Milena and Jotić, Aleksandra and Pucar, Ana",
year = "2018",
abstract = "Background/Aim: The aim of this study was to examine prevalence of different Candida spp. at diabetics and nondiabetics wearing dentures without clinical signs of Denture Stomatitis (DS) and to study if some local and systematic factors are confounders for harboring Candida at these subjects. Material and Methods: Total of 60 subjects wearing partial or complete upper acrylic denture having at least half of palatal mucosa covered by denture were selected and stratified into three experimental groups: systematically health subjects; patients with diagnosed Type 2 Diabetes (T2D) and good glycoregulation; and T2D subjects with poorly regulated blood sugar level. Cotton swab samples were obtained from each patient from hard palate mucosa and denture surface. Swab cultures were made on Sabouraud dextrose agar and ChromAgar Media for distinciton of various Candida spp. Density growth was also measured. Results: Frequency of Candida spp. findings were similar between groups. At healthy subjects, only C.albicans was detected. At diabetics, C.albicans was the most common isolated species, followed by C.glabrata and C.tropicalis. Negative finding of yeasts on palatal mucosa, but positive on denture surface were detected at all groups, with the highest frequency (33.4%) at diabetics with poor glycoregulation. Denture surface was heavier colonized than hard palate mucosa. Duration of diabetes in years were only independent predictors for harboring Candida spp. at denture surface (Exp B=1.186, CI=1.047-1.344, p=0.007). Conclusions: Prosthesis of denture wearers without DS may serve as reservoir of Candida spp. Presence of more pathogenic and resistant non-albicans species are related to diabetics, even without clinical signs of DS.",
publisher = "Udruženje stomatologa Balkana",
journal = "Balkan Journal of Dental Medicine",
title = "Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study",
volume = "22",
number = "1",
pages = "15-21",
doi = "10.2478/bjdm-2018-0003"
}
Matić-Petrović, S., Barać, M., Kuzmanović-Pfićer, J., Radunović, M., Jotić, A.,& Pucar, A.. (2018). Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study. in Balkan Journal of Dental Medicine
Udruženje stomatologa Balkana., 22(1), 15-21.
https://doi.org/10.2478/bjdm-2018-0003
Matić-Petrović S, Barać M, Kuzmanović-Pfićer J, Radunović M, Jotić A, Pucar A. Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study. in Balkan Journal of Dental Medicine. 2018;22(1):15-21.
doi:10.2478/bjdm-2018-0003 .
Matić-Petrović, Sanja, Barać, Milena, Kuzmanović-Pfićer, Jovana, Radunović, Milena, Jotić, Aleksandra, Pucar, Ana, "Presence of different Candida species at denture wearers with type 2 diabetes and clinically healthy oral mucosa: Pilot study" in Balkan Journal of Dental Medicine, 22, no. 1 (2018):15-21,
https://doi.org/10.2478/bjdm-2018-0003 . .
3

The severity of denture stomatitis as related to risk factors and different Candida spp.

Perić, Mirjana; Živković, Rade; Milić-Lemić, Aleksandra; Radunović, Milena; Miličić, Biljana; Arsić-Arsenijević, Valentina

(Elsevier Science Inc, New York, 2018)

TY  - JOUR
AU  - Perić, Mirjana
AU  - Živković, Rade
AU  - Milić-Lemić, Aleksandra
AU  - Radunović, Milena
AU  - Miličić, Biljana
AU  - Arsić-Arsenijević, Valentina
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2298
AB  - Objectives. 1) To select patients with Candida-related denture stomatitis (DS) and to study possible risk factors associated with DS, 2) to evaluate the severity of DS according to Newton's classification, and 3) to investigate the association between the presence of non-albicans Candida spp. (NAC) or mixed Candida spp. and the severity of DS. Study Design. Eighty-two patients with Candida-positive DS have undergone 1) filling in the interview questionnaire, 2) clinical examination, and 3) microbiologic examination. Results. A total of 113 Candida spp. isolates were obtained from Candida-positive DS patients: C. albicans (as a single species) in 47/82 (57%) patients (study group A [SG_A]) and NAC/mixed Candida spp. in 35/82 (43%) patients (SG_B). Univariate logistic regression analysis showed that older age, longer age of the mandibular denture, and ex-smoker status were associated with SG_A. A multivariate model revealed no significant predictor of DS severity. Patients from SG_A were 3 times as likely to have DS type I, while patients from SG_B were 4.9 times as likely to have DS type III. Conclusions. Our results show the association between type III of DS (by Newton's classification) and the presence of NAC or mixed Candida spp. in denture wearers.
PB  - Elsevier Science Inc, New York
T2  - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
T1  - The severity of denture stomatitis as related to risk factors and different Candida spp.
VL  - 126
IS  - 1
SP  - 41
EP  - 47
DO  - 10.1016/j.oooo.2018.03.003
ER  - 
@article{
author = "Perić, Mirjana and Živković, Rade and Milić-Lemić, Aleksandra and Radunović, Milena and Miličić, Biljana and Arsić-Arsenijević, Valentina",
year = "2018",
abstract = "Objectives. 1) To select patients with Candida-related denture stomatitis (DS) and to study possible risk factors associated with DS, 2) to evaluate the severity of DS according to Newton's classification, and 3) to investigate the association between the presence of non-albicans Candida spp. (NAC) or mixed Candida spp. and the severity of DS. Study Design. Eighty-two patients with Candida-positive DS have undergone 1) filling in the interview questionnaire, 2) clinical examination, and 3) microbiologic examination. Results. A total of 113 Candida spp. isolates were obtained from Candida-positive DS patients: C. albicans (as a single species) in 47/82 (57%) patients (study group A [SG_A]) and NAC/mixed Candida spp. in 35/82 (43%) patients (SG_B). Univariate logistic regression analysis showed that older age, longer age of the mandibular denture, and ex-smoker status were associated with SG_A. A multivariate model revealed no significant predictor of DS severity. Patients from SG_A were 3 times as likely to have DS type I, while patients from SG_B were 4.9 times as likely to have DS type III. Conclusions. Our results show the association between type III of DS (by Newton's classification) and the presence of NAC or mixed Candida spp. in denture wearers.",
publisher = "Elsevier Science Inc, New York",
journal = "Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology",
title = "The severity of denture stomatitis as related to risk factors and different Candida spp.",
volume = "126",
number = "1",
pages = "41-47",
doi = "10.1016/j.oooo.2018.03.003"
}
Perić, M., Živković, R., Milić-Lemić, A., Radunović, M., Miličić, B.,& Arsić-Arsenijević, V.. (2018). The severity of denture stomatitis as related to risk factors and different Candida spp.. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Elsevier Science Inc, New York., 126(1), 41-47.
https://doi.org/10.1016/j.oooo.2018.03.003
Perić M, Živković R, Milić-Lemić A, Radunović M, Miličić B, Arsić-Arsenijević V. The severity of denture stomatitis as related to risk factors and different Candida spp.. in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2018;126(1):41-47.
doi:10.1016/j.oooo.2018.03.003 .
Perić, Mirjana, Živković, Rade, Milić-Lemić, Aleksandra, Radunović, Milena, Miličić, Biljana, Arsić-Arsenijević, Valentina, "The severity of denture stomatitis as related to risk factors and different Candida spp." in Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, 126, no. 1 (2018):41-47,
https://doi.org/10.1016/j.oooo.2018.03.003 . .
28
10
23

Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface

De Colli, Marianna; Radunović, Milena; Zizzari, Vincenzo L.; Di Giacomo, Viviana; Di Nisio, Chiara; Piattelli, Adriano; Calvo Guirado, Jose Luis; Zavan, Barbara; Cataldi, Amelia; Zara, Susi

(Japanese Soc Dental Materials Devices, Tokyo, 2018)

TY  - JOUR
AU  - De Colli, Marianna
AU  - Radunović, Milena
AU  - Zizzari, Vincenzo L.
AU  - Di Giacomo, Viviana
AU  - Di Nisio, Chiara
AU  - Piattelli, Adriano
AU  - Calvo Guirado, Jose Luis
AU  - Zavan, Barbara
AU  - Cataldi, Amelia
AU  - Zara, Susi
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2304
AB  - Titanium surface modification is critical for dental implant success. Our aim was to determine surfaces influence on dental pulp stem cells (DPSCs) viability and differentiation. Implants were divided into sandblasted/acid-etched (control) and sandblasted/acid-etched coated with calcium and magnesium ions (CaMg), supplied as composite (test). Proliferation was evaluated by MTT, differentiation checking osteoblastic gene expression, PGE2 secretion and matrix formation, inflammation by Interleukin 6 (IL-6) detection. MTT and IL-6 do not modify on test. A PGE2 increase on test is recorded. BMP2 is higher on test at early experimental points, Osterix and RUNX2 augment later. Alizarin-red S reveals higher matrix production on test. These results suggest that test surface is more osteoinductive, representing a start point for in vivo studies aiming at the construction of more biocompatible dental implants, whose integration and clinical performance are improved and some undesired effects, such as implant stability loss and further surgical procedures, are reduced.
PB  - Japanese Soc Dental Materials Devices, Tokyo
T2  - Dental Materials Journal
T1  - Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface
VL  - 37
IS  - 2
SP  - 197
EP  - 205
DO  - 10.4012/dmj.2016-418
ER  - 
@article{
author = "De Colli, Marianna and Radunović, Milena and Zizzari, Vincenzo L. and Di Giacomo, Viviana and Di Nisio, Chiara and Piattelli, Adriano and Calvo Guirado, Jose Luis and Zavan, Barbara and Cataldi, Amelia and Zara, Susi",
year = "2018",
abstract = "Titanium surface modification is critical for dental implant success. Our aim was to determine surfaces influence on dental pulp stem cells (DPSCs) viability and differentiation. Implants were divided into sandblasted/acid-etched (control) and sandblasted/acid-etched coated with calcium and magnesium ions (CaMg), supplied as composite (test). Proliferation was evaluated by MTT, differentiation checking osteoblastic gene expression, PGE2 secretion and matrix formation, inflammation by Interleukin 6 (IL-6) detection. MTT and IL-6 do not modify on test. A PGE2 increase on test is recorded. BMP2 is higher on test at early experimental points, Osterix and RUNX2 augment later. Alizarin-red S reveals higher matrix production on test. These results suggest that test surface is more osteoinductive, representing a start point for in vivo studies aiming at the construction of more biocompatible dental implants, whose integration and clinical performance are improved and some undesired effects, such as implant stability loss and further surgical procedures, are reduced.",
publisher = "Japanese Soc Dental Materials Devices, Tokyo",
journal = "Dental Materials Journal",
title = "Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface",
volume = "37",
number = "2",
pages = "197-205",
doi = "10.4012/dmj.2016-418"
}
De Colli, M., Radunović, M., Zizzari, V. L., Di Giacomo, V., Di Nisio, C., Piattelli, A., Calvo Guirado, J. L., Zavan, B., Cataldi, A.,& Zara, S.. (2018). Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface. in Dental Materials Journal
Japanese Soc Dental Materials Devices, Tokyo., 37(2), 197-205.
https://doi.org/10.4012/dmj.2016-418
De Colli M, Radunović M, Zizzari VL, Di Giacomo V, Di Nisio C, Piattelli A, Calvo Guirado JL, Zavan B, Cataldi A, Zara S. Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface. in Dental Materials Journal. 2018;37(2):197-205.
doi:10.4012/dmj.2016-418 .
De Colli, Marianna, Radunović, Milena, Zizzari, Vincenzo L., Di Giacomo, Viviana, Di Nisio, Chiara, Piattelli, Adriano, Calvo Guirado, Jose Luis, Zavan, Barbara, Cataldi, Amelia, Zara, Susi, "Osteoblastic differentiating potential of dental pulp stem cells in vitro cultured on a chemically modified microrough titanium surface" in Dental Materials Journal, 37, no. 2 (2018):197-205,
https://doi.org/10.4012/dmj.2016-418 . .
17
14
17

Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population

Bogdanović, Ljiljana; Lazić, Miodrag; Bogdanović, Jelena; Soldatović, Ivan; Nikolić, Nadja; Radunović, Milena; Radojević-Škodrić, Sanja; Milašin, Jelena; Basta-Jovanović, Gordana

(Balkan Union of Oncology (B.U.ON.), 2017)

TY  - JOUR
AU  - Bogdanović, Ljiljana
AU  - Lazić, Miodrag
AU  - Bogdanović, Jelena
AU  - Soldatović, Ivan
AU  - Nikolić, Nadja
AU  - Radunović, Milena
AU  - Radojević-Škodrić, Sanja
AU  - Milašin, Jelena
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2182
AB  - Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population
VL  - 22
IS  - 1
SP  - 270
EP  - 277
UR  - https://hdl.handle.net/21.15107/rcub_smile_2182
ER  - 
@article{
author = "Bogdanović, Ljiljana and Lazić, Miodrag and Bogdanović, Jelena and Soldatović, Ivan and Nikolić, Nadja and Radunović, Milena and Radojević-Škodrić, Sanja and Milašin, Jelena and Basta-Jovanović, Gordana",
year = "2017",
abstract = "Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population",
volume = "22",
number = "1",
pages = "270-277",
url = "https://hdl.handle.net/21.15107/rcub_smile_2182"
}
Bogdanović, L., Lazić, M., Bogdanović, J., Soldatović, I., Nikolić, N., Radunović, M., Radojević-Škodrić, S., Milašin, J.,& Basta-Jovanović, G.. (2017). Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(1), 270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182
Bogdanović L, Lazić M, Bogdanović J, Soldatović I, Nikolić N, Radunović M, Radojević-Škodrić S, Milašin J, Basta-Jovanović G. Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON. 2017;22(1):270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182 .
Bogdanović, Ljiljana, Lazić, Miodrag, Bogdanović, Jelena, Soldatović, Ivan, Nikolić, Nadja, Radunović, Milena, Radojević-Škodrić, Sanja, Milašin, Jelena, Basta-Jovanović, Gordana, "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population" in Journal of BUON, 22, no. 1 (2017):270-277,
https://hdl.handle.net/21.15107/rcub_smile_2182 .
2

Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts

De Marco, Patrizia; Zara, Susi; De Colli, Marianna; Radunović, Milena; Lazović, Vladimir; Ettorre, Valeria; Di Crescenzo, Antonello; Piattelli, Adriano; Cataldi, Amelia; Fontana, Antonella

(Iop Publishing Ltd, Bristol, 2017)

TY  - JOUR
AU  - De Marco, Patrizia
AU  - Zara, Susi
AU  - De Colli, Marianna
AU  - Radunović, Milena
AU  - Lazović, Vladimir
AU  - Ettorre, Valeria
AU  - Di Crescenzo, Antonello
AU  - Piattelli, Adriano
AU  - Cataldi, Amelia
AU  - Fontana, Antonella
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2218
AB  - Commercial collagen membranes are used in oral surgical procedures as scaffolds for bone deposition in guided bone regeneration. Here, we have enriched them with graphene oxide (GO) via a simple non-covalent functionalization, exploiting the capacity of oxygenated carbon functional moieties of GO to interact through hydrogen bonding with collagen. In the present paper, the GO-coated membranes have been characterized in terms of stability, nano-roughness, biocompatibility and induction of inflammatory response in human primary gingival fibroblast cells. The obtained coated membranes are demonstrated not to leak GO in the bulk solution, and to change some features of the membrane, such as stiffness and adhesion between the membrane and the atomic force microscopy (AFM) tip. Moreover, the presence of GO increases the roughness and the total surface exposed to the cells, as demonstrated by AFM analyses. The obtained material is biocompatible, and does not induce inflammation in the tested cells.
PB  - Iop Publishing Ltd, Bristol
T2  - Biomedical Materials
T1  - Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts
VL  - 12
IS  - 5
DO  - 10.1088/1748-605X/aa7907
ER  - 
@article{
author = "De Marco, Patrizia and Zara, Susi and De Colli, Marianna and Radunović, Milena and Lazović, Vladimir and Ettorre, Valeria and Di Crescenzo, Antonello and Piattelli, Adriano and Cataldi, Amelia and Fontana, Antonella",
year = "2017",
abstract = "Commercial collagen membranes are used in oral surgical procedures as scaffolds for bone deposition in guided bone regeneration. Here, we have enriched them with graphene oxide (GO) via a simple non-covalent functionalization, exploiting the capacity of oxygenated carbon functional moieties of GO to interact through hydrogen bonding with collagen. In the present paper, the GO-coated membranes have been characterized in terms of stability, nano-roughness, biocompatibility and induction of inflammatory response in human primary gingival fibroblast cells. The obtained coated membranes are demonstrated not to leak GO in the bulk solution, and to change some features of the membrane, such as stiffness and adhesion between the membrane and the atomic force microscopy (AFM) tip. Moreover, the presence of GO increases the roughness and the total surface exposed to the cells, as demonstrated by AFM analyses. The obtained material is biocompatible, and does not induce inflammation in the tested cells.",
publisher = "Iop Publishing Ltd, Bristol",
journal = "Biomedical Materials",
title = "Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts",
volume = "12",
number = "5",
doi = "10.1088/1748-605X/aa7907"
}
De Marco, P., Zara, S., De Colli, M., Radunović, M., Lazović, V., Ettorre, V., Di Crescenzo, A., Piattelli, A., Cataldi, A.,& Fontana, A.. (2017). Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts. in Biomedical Materials
Iop Publishing Ltd, Bristol., 12(5).
https://doi.org/10.1088/1748-605X/aa7907
De Marco P, Zara S, De Colli M, Radunović M, Lazović V, Ettorre V, Di Crescenzo A, Piattelli A, Cataldi A, Fontana A. Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts. in Biomedical Materials. 2017;12(5).
doi:10.1088/1748-605X/aa7907 .
De Marco, Patrizia, Zara, Susi, De Colli, Marianna, Radunović, Milena, Lazović, Vladimir, Ettorre, Valeria, Di Crescenzo, Antonello, Piattelli, Adriano, Cataldi, Amelia, Fontana, Antonella, "Graphene oxide improves the biocompatibility of collagen membranes in an in vitro model of human primary gingival fibroblasts" in Biomedical Materials, 12, no. 5 (2017),
https://doi.org/10.1088/1748-605X/aa7907 . .
36
22
38

Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma

Latić, Dragana; Radojević-Škodrić, Sanja; Nikolić, Srđan; Prvanović, Mirjana; Lazić, Miodrag; Džamić, Zoran; Bogdanović, Ljiljana; Radunović, Milena; Vuković, Marina

(Balkan Union of Oncology (B.U.ON.), 2017)

TY  - JOUR
AU  - Latić, Dragana
AU  - Radojević-Škodrić, Sanja
AU  - Nikolić, Srđan
AU  - Prvanović, Mirjana
AU  - Lazić, Miodrag
AU  - Džamić, Zoran
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Vuković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2206
AB  - Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
VL  - 22
IS  - 5
SP  - 1322
EP  - 1327
UR  - https://hdl.handle.net/21.15107/rcub_smile_2206
ER  - 
@article{
author = "Latić, Dragana and Radojević-Škodrić, Sanja and Nikolić, Srđan and Prvanović, Mirjana and Lazić, Miodrag and Džamić, Zoran and Bogdanović, Ljiljana and Radunović, Milena and Vuković, Marina",
year = "2017",
abstract = "Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma",
volume = "22",
number = "5",
pages = "1322-1327",
url = "https://hdl.handle.net/21.15107/rcub_smile_2206"
}
Latić, D., Radojević-Škodrić, S., Nikolić, S., Prvanović, M., Lazić, M., Džamić, Z., Bogdanović, L., Radunović, M.,& Vuković, M.. (2017). Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(5), 1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206
Latić D, Radojević-Škodrić S, Nikolić S, Prvanović M, Lazić M, Džamić Z, Bogdanović L, Radunović M, Vuković M. Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON. 2017;22(5):1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206 .
Latić, Dragana, Radojević-Škodrić, Sanja, Nikolić, Srđan, Prvanović, Mirjana, Lazić, Miodrag, Džamić, Zoran, Bogdanović, Ljiljana, Radunović, Milena, Vuković, Marina, "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma" in Journal of BUON, 22, no. 5 (2017):1322-1327,
https://hdl.handle.net/21.15107/rcub_smile_2206 .
1

Graphene oxide enrichment of collagen membranes improves DPSCs differentiation and controls inflammation occurrence

Radunović, Milena; De Colli, Marianna; De Marco, Patrizia; Di Nisio, Chiara; Fontana, Antonella; Piattelli, Adriano; Cataldi, Amelia; Zara, Susi

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Radunović, Milena
AU  - De Colli, Marianna
AU  - De Marco, Patrizia
AU  - Di Nisio, Chiara
AU  - Fontana, Antonella
AU  - Piattelli, Adriano
AU  - Cataldi, Amelia
AU  - Zara, Susi
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2186
AB  - Collagen membranes are used in oral surgery for bone defects treatment acting as a barrier that does not allow the invasion of soft tissue into the growing bone. To improve biocompatibility collagen membranes were coated with graphene oxide (GO), a graphene derivative. The aim of this study was to investigate the biocompatibility of GO coated collagen membranes on human dental pulp stem cells (DPSCs) focusing on biomaterial cytotoxicity, ability to promote DPSCs differentiation process and to control inflammation event induction. DPSCs were cultured on uncoated membranes and on both 2 and 10 mu g mL(-1) GO coated membranes up to 28 days. Alamar blue and LDH cytotocicity assay, PGE2 ELISA assay, real time RT-PCR for RUNX2, BMP2, SP7, TNF alpha and COX2 genes expression were performed. Proliferation is higher on GO coated membranes at days 14 and 28. LDH assay evidences no cytotoxicity. BMP2 and RUNX2 expression is higher on coated membranes, BMP2 at early and RUNX2 and SP7 at late experimental times. PGE2 levels are lower on GO coated membranes at days 14 and 28, both TNF alpha and COX2 expression is significantly decreased when GO is applied. GO coated membranes are not toxic for DPSCs, induce a faster DPSCs differentiation into odontoblasts/osteoblasts and may represent good alternative to conventional membranes thus ensuring more efficient bone formation and improving the clinical performance.
PB  - Wiley, Hoboken
T2  - Journal of Biomedical Materials Research Part A
T1  - Graphene oxide enrichment of collagen membranes improves DPSCs differentiation and controls inflammation occurrence
VL  - 105
IS  - 8
SP  - 2312
EP  - 2320
DO  - 10.1002/jbm.a.36085
ER  - 
@article{
author = "Radunović, Milena and De Colli, Marianna and De Marco, Patrizia and Di Nisio, Chiara and Fontana, Antonella and Piattelli, Adriano and Cataldi, Amelia and Zara, Susi",
year = "2017",
abstract = "Collagen membranes are used in oral surgery for bone defects treatment acting as a barrier that does not allow the invasion of soft tissue into the growing bone. To improve biocompatibility collagen membranes were coated with graphene oxide (GO), a graphene derivative. The aim of this study was to investigate the biocompatibility of GO coated collagen membranes on human dental pulp stem cells (DPSCs) focusing on biomaterial cytotoxicity, ability to promote DPSCs differentiation process and to control inflammation event induction. DPSCs were cultured on uncoated membranes and on both 2 and 10 mu g mL(-1) GO coated membranes up to 28 days. Alamar blue and LDH cytotocicity assay, PGE2 ELISA assay, real time RT-PCR for RUNX2, BMP2, SP7, TNF alpha and COX2 genes expression were performed. Proliferation is higher on GO coated membranes at days 14 and 28. LDH assay evidences no cytotoxicity. BMP2 and RUNX2 expression is higher on coated membranes, BMP2 at early and RUNX2 and SP7 at late experimental times. PGE2 levels are lower on GO coated membranes at days 14 and 28, both TNF alpha and COX2 expression is significantly decreased when GO is applied. GO coated membranes are not toxic for DPSCs, induce a faster DPSCs differentiation into odontoblasts/osteoblasts and may represent good alternative to conventional membranes thus ensuring more efficient bone formation and improving the clinical performance.",
publisher = "Wiley, Hoboken",
journal = "Journal of Biomedical Materials Research Part A",
title = "Graphene oxide enrichment of collagen membranes improves DPSCs differentiation and controls inflammation occurrence",
volume = "105",
number = "8",
pages = "2312-2320",
doi = "10.1002/jbm.a.36085"
}
Radunović, M., De Colli, M., De Marco, P., Di Nisio, C., Fontana, A., Piattelli, A., Cataldi, A.,& Zara, S.. (2017). Graphene oxide enrichment of collagen membranes improves DPSCs differentiation and controls inflammation occurrence. in Journal of Biomedical Materials Research Part A
Wiley, Hoboken., 105(8), 2312-2320.
https://doi.org/10.1002/jbm.a.36085
Radunović M, De Colli M, De Marco P, Di Nisio C, Fontana A, Piattelli A, Cataldi A, Zara S. Graphene oxide enrichment of collagen membranes improves DPSCs differentiation and controls inflammation occurrence. in Journal of Biomedical Materials Research Part A. 2017;105(8):2312-2320.
doi:10.1002/jbm.a.36085 .
Radunović, Milena, De Colli, Marianna, De Marco, Patrizia, Di Nisio, Chiara, Fontana, Antonella, Piattelli, Adriano, Cataldi, Amelia, Zara, Susi, "Graphene oxide enrichment of collagen membranes improves DPSCs differentiation and controls inflammation occurrence" in Journal of Biomedical Materials Research Part A, 105, no. 8 (2017):2312-2320,
https://doi.org/10.1002/jbm.a.36085 . .
47
28
49

The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer

Radunović, Milena; Nikolić, Nadja; Milenković, Sanja; Tomanović, Nada; Boričić, Ivan; Dimitrijević, Milovan; Novaković, Ivana; Basta-Jovanović, Gordana

(Balkan Union of Oncology (B.U.ON.), 2016)

TY  - JOUR
AU  - Radunović, Milena
AU  - Nikolić, Nadja
AU  - Milenković, Sanja
AU  - Tomanović, Nada
AU  - Boričić, Ivan
AU  - Dimitrijević, Milovan
AU  - Novaković, Ivana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2178
AB  - Purpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer
VL  - 21
IS  - 3
SP  - 597
EP  - 602
UR  - https://hdl.handle.net/21.15107/rcub_smile_2178
ER  - 
@article{
author = "Radunović, Milena and Nikolić, Nadja and Milenković, Sanja and Tomanović, Nada and Boričić, Ivan and Dimitrijević, Milovan and Novaković, Ivana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer",
volume = "21",
number = "3",
pages = "597-602",
url = "https://hdl.handle.net/21.15107/rcub_smile_2178"
}
Radunović, M., Nikolić, N., Milenković, S., Tomanović, N., Boričić, I., Dimitrijević, M., Novaković, I.,& Basta-Jovanović, G.. (2016). The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(3), 597-602.
https://hdl.handle.net/21.15107/rcub_smile_2178
Radunović M, Nikolić N, Milenković S, Tomanović N, Boričić I, Dimitrijević M, Novaković I, Basta-Jovanović G. The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer. in Journal of BUON. 2016;21(3):597-602.
https://hdl.handle.net/21.15107/rcub_smile_2178 .
Radunović, Milena, Nikolić, Nadja, Milenković, Sanja, Tomanović, Nada, Boričić, Ivan, Dimitrijević, Milovan, Novaković, Ivana, Basta-Jovanović, Gordana, "The MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland cancer" in Journal of BUON, 21, no. 3 (2016):597-602,
https://hdl.handle.net/21.15107/rcub_smile_2178 .
12

Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation

Basta-Jovanović, Gordana; Bogdanović, Ljiljana; Radunović, Milena; Prostran, Milica S.; Naumović, R.; Simić-Ogrizović, Sanja; Radojević-Škodrić, Sanja

(Bentham Science Publ Ltd, Sharjah, 2016)

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Prostran, Milica S.
AU  - Naumović, R.
AU  - Simić-Ogrizović, Sanja
AU  - Radojević-Škodrić, Sanja
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2094
AB  - Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation
VL  - 23
IS  - 19
SP  - 2012
EP  - 2017
DO  - 10.2174/092986732319160719192019
ER  - 
@article{
author = "Basta-Jovanović, Gordana and Bogdanović, Ljiljana and Radunović, Milena and Prostran, Milica S. and Naumović, R. and Simić-Ogrizović, Sanja and Radojević-Škodrić, Sanja",
year = "2016",
abstract = "Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation",
volume = "23",
number = "19",
pages = "2012-2017",
doi = "10.2174/092986732319160719192019"
}
Basta-Jovanović, G., Bogdanović, L., Radunović, M., Prostran, M. S., Naumović, R., Simić-Ogrizović, S.,& Radojević-Škodrić, S.. (2016). Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 23(19), 2012-2017.
https://doi.org/10.2174/092986732319160719192019
Basta-Jovanović G, Bogdanović L, Radunović M, Prostran MS, Naumović R, Simić-Ogrizović S, Radojević-Škodrić S. Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry. 2016;23(19):2012-2017.
doi:10.2174/092986732319160719192019 .
Basta-Jovanović, Gordana, Bogdanović, Ljiljana, Radunović, Milena, Prostran, Milica S., Naumović, R., Simić-Ogrizović, Sanja, Radojević-Škodrić, Sanja, "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation" in Current Medicinal Chemistry, 23, no. 19 (2016):2012-2017,
https://doi.org/10.2174/092986732319160719192019 . .
1
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5

Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer

Radunović, Milena; Tomanović, Nada; Novaković, Ivana; Boričić, Ivan; Milenković, Sanja; Dimitrijević, Milovan; Radojević-Škodrić, Sanja; Bogdanović, Ljiljana; Basta-Jovanović, Gordana

(Balkan Union of Oncology (B.U.ON.), 2016)

TY  - JOUR
AU  - Radunović, Milena
AU  - Tomanović, Nada
AU  - Novaković, Ivana
AU  - Boričić, Ivan
AU  - Milenković, Sanja
AU  - Dimitrijević, Milovan
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, Ljiljana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2077
AB  - Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer
VL  - 21
IS  - 6
SP  - 1530
EP  - 1536
UR  - https://hdl.handle.net/21.15107/rcub_smile_2077
ER  - 
@article{
author = "Radunović, Milena and Tomanović, Nada and Novaković, Ivana and Boričić, Ivan and Milenković, Sanja and Dimitrijević, Milovan and Radojević-Škodrić, Sanja and Bogdanović, Ljiljana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer",
volume = "21",
number = "6",
pages = "1530-1536",
url = "https://hdl.handle.net/21.15107/rcub_smile_2077"
}
Radunović, M., Tomanović, N., Novaković, I., Boričić, I., Milenković, S., Dimitrijević, M., Radojević-Škodrić, S., Bogdanović, L.,& Basta-Jovanović, G.. (2016). Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(6), 1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077
Radunović M, Tomanović N, Novaković I, Boričić I, Milenković S, Dimitrijević M, Radojević-Škodrić S, Bogdanović L, Basta-Jovanović G. Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON. 2016;21(6):1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077 .
Radunović, Milena, Tomanović, Nada, Novaković, Ivana, Boričić, Ivan, Milenković, Sanja, Dimitrijević, Milovan, Radojević-Škodrić, Sanja, Bogdanović, Ljiljana, Basta-Jovanović, Gordana, "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer" in Journal of BUON, 21, no. 6 (2016):1530-1536,
https://hdl.handle.net/21.15107/rcub_smile_2077 .
4

Detection and sampling methods for isolation of Candida spp. from oral cavities in diabetics and non-diabetics

Matić-Petrović, Sanja; Cimbaljević, Milena; Radunović, Milena; Kuzmanović-Pfićer, Jovana; Jotić, Aleksandra; Pucar, Ana

(Sociedade Brasileira De Pesquisa Odontologica, Sao Paulo, 2015)

TY  - JOUR
AU  - Matić-Petrović, Sanja
AU  - Cimbaljević, Milena
AU  - Radunović, Milena
AU  - Kuzmanović-Pfićer, Jovana
AU  - Jotić, Aleksandra
AU  - Pucar, Ana
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2052
AB  - The purpose of this study was to detect Candida spp. on the tongue and in the subgingival sites in healthy and type 2 diabetes (T2D) patients with chronic periodontitis (CP), and to compare the accuracy of sampling methods. This study included 131 patients divided into four groups: healthy control (group A), nondiabetics + CP (Group B), diabetics with good metabolic control + CP (group C) and diabetics with poor glycoregulation + CP (Group D). Cotton swab samples from tongue and subgingival samples were obtained from each patient with help of sterile paper points and a sterile curette. Swab cultures were made on Sabouraud dextrose agar. The number of CFUs was counted. The sampling methods for subgingival plaque were compared by Receiving Operator Curve (ROC). The presence of Candida spp. on the tongue was statistically significant among groups (group D vs. others three groups:.2: p  lt  0.005 for each group). Positive findings of subgingival Candida spp. did not differ among the groups. There were no significant differences in the quantification of Candida spp., neither on the tongue, nor in the subgingival samples. 17.2% of diabetic patients revealed the presence of Candida spp. in the subgingival samples, with negative finding on tongue. There was a significant difference in the sampling methods for subgingival plaque (p = 0.000). Candida spp. is more prevalent on the tongue of diabetics. The sampling of subgingival plaque by a sterile curette is more accurate than with paper points. Subgingival plaque may represent a reservoir of commensals. It is necessary to standardize the sampling of subgingival plaque.
PB  - Sociedade Brasileira De Pesquisa Odontologica, Sao Paulo
T2  - Brazilian Oral Research
T1  - Detection and sampling methods for isolation of Candida spp. from oral cavities in diabetics and non-diabetics
VL  - 29
IS  - 1
DO  - 10.1590/1807-3107BOR-2015.vol29.0077
ER  - 
@article{
author = "Matić-Petrović, Sanja and Cimbaljević, Milena and Radunović, Milena and Kuzmanović-Pfićer, Jovana and Jotić, Aleksandra and Pucar, Ana",
year = "2015",
abstract = "The purpose of this study was to detect Candida spp. on the tongue and in the subgingival sites in healthy and type 2 diabetes (T2D) patients with chronic periodontitis (CP), and to compare the accuracy of sampling methods. This study included 131 patients divided into four groups: healthy control (group A), nondiabetics + CP (Group B), diabetics with good metabolic control + CP (group C) and diabetics with poor glycoregulation + CP (Group D). Cotton swab samples from tongue and subgingival samples were obtained from each patient with help of sterile paper points and a sterile curette. Swab cultures were made on Sabouraud dextrose agar. The number of CFUs was counted. The sampling methods for subgingival plaque were compared by Receiving Operator Curve (ROC). The presence of Candida spp. on the tongue was statistically significant among groups (group D vs. others three groups:.2: p  lt  0.005 for each group). Positive findings of subgingival Candida spp. did not differ among the groups. There were no significant differences in the quantification of Candida spp., neither on the tongue, nor in the subgingival samples. 17.2% of diabetic patients revealed the presence of Candida spp. in the subgingival samples, with negative finding on tongue. There was a significant difference in the sampling methods for subgingival plaque (p = 0.000). Candida spp. is more prevalent on the tongue of diabetics. The sampling of subgingival plaque by a sterile curette is more accurate than with paper points. Subgingival plaque may represent a reservoir of commensals. It is necessary to standardize the sampling of subgingival plaque.",
publisher = "Sociedade Brasileira De Pesquisa Odontologica, Sao Paulo",
journal = "Brazilian Oral Research",
title = "Detection and sampling methods for isolation of Candida spp. from oral cavities in diabetics and non-diabetics",
volume = "29",
number = "1",
doi = "10.1590/1807-3107BOR-2015.vol29.0077"
}
Matić-Petrović, S., Cimbaljević, M., Radunović, M., Kuzmanović-Pfićer, J., Jotić, A.,& Pucar, A.. (2015). Detection and sampling methods for isolation of Candida spp. from oral cavities in diabetics and non-diabetics. in Brazilian Oral Research
Sociedade Brasileira De Pesquisa Odontologica, Sao Paulo., 29(1).
https://doi.org/10.1590/1807-3107BOR-2015.vol29.0077
Matić-Petrović S, Cimbaljević M, Radunović M, Kuzmanović-Pfićer J, Jotić A, Pucar A. Detection and sampling methods for isolation of Candida spp. from oral cavities in diabetics and non-diabetics. in Brazilian Oral Research. 2015;29(1).
doi:10.1590/1807-3107BOR-2015.vol29.0077 .
Matić-Petrović, Sanja, Cimbaljević, Milena, Radunović, Milena, Kuzmanović-Pfićer, Jovana, Jotić, Aleksandra, Pucar, Ana, "Detection and sampling methods for isolation of Candida spp. from oral cavities in diabetics and non-diabetics" in Brazilian Oral Research, 29, no. 1 (2015),
https://doi.org/10.1590/1807-3107BOR-2015.vol29.0077 . .
1
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7

Presence, species distribution, and density of Malassezia yeast in patients with seborrhoeic dermatitis - a community-based case-control study and review of literature

Barac, Aleksandra; Pekmezović, Marina; Milobratović, Danica; Otašević-Tasić, Suzana; Radunović, Milena; Arsić-Arsenijević, Valentina

(Wiley, Hoboken, 2015)

TY  - JOUR
AU  - Barac, Aleksandra
AU  - Pekmezović, Marina
AU  - Milobratović, Danica
AU  - Otašević-Tasić, Suzana
AU  - Radunović, Milena
AU  - Arsić-Arsenijević, Valentina
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2023
AB  - Malassezia yeast belongs to the normal cutaneous flora and under certain conditions it causes seborrhoeic dermatitis (SD). There is no culture-based study about the presence and density of the Malassezia in SD patients in Serbia. Aim was to show the presence, species distribution and density of Malassezia in patients with SD on lesional skin (LS) and non-lesional skin (NLS) and healthy controls (HC) and to compare data between Serbia and other countries. The study included 70 HC and 60 patients with SD in the study group (SG). Isolation, identification and examination of density of Malassezia colony-forming units from LS and NLS were performed. Malassezia was found more frequently in the SG than in HC, 90% and 60%, respectively (P lt 0.01). The most frequent isolates in SG on LS were M. slooffiae (26%), followed by M. globosa (17%) and M. sympodialis (17%). The yeast density was much higher on LS of SG than on NLS of SG or in the HC group (P lt 0.05). Higher density of Malassezia was shown on LS of SG than on NLS of SG and HC. M. slooffiae is the most prevalent species in SD patients in Serbia. This study demonstrated a positive relationship between severity of SD and presence of Malassezia spp.
PB  - Wiley, Hoboken
T2  - Mycoses
T1  - Presence, species distribution, and density of Malassezia yeast in patients with seborrhoeic dermatitis - a community-based case-control study and review of literature
VL  - 58
IS  - 2
SP  - 69
EP  - 75
DO  - 10.1111/myc.12276
ER  - 
@article{
author = "Barac, Aleksandra and Pekmezović, Marina and Milobratović, Danica and Otašević-Tasić, Suzana and Radunović, Milena and Arsić-Arsenijević, Valentina",
year = "2015",
abstract = "Malassezia yeast belongs to the normal cutaneous flora and under certain conditions it causes seborrhoeic dermatitis (SD). There is no culture-based study about the presence and density of the Malassezia in SD patients in Serbia. Aim was to show the presence, species distribution and density of Malassezia in patients with SD on lesional skin (LS) and non-lesional skin (NLS) and healthy controls (HC) and to compare data between Serbia and other countries. The study included 70 HC and 60 patients with SD in the study group (SG). Isolation, identification and examination of density of Malassezia colony-forming units from LS and NLS were performed. Malassezia was found more frequently in the SG than in HC, 90% and 60%, respectively (P lt 0.01). The most frequent isolates in SG on LS were M. slooffiae (26%), followed by M. globosa (17%) and M. sympodialis (17%). The yeast density was much higher on LS of SG than on NLS of SG or in the HC group (P lt 0.05). Higher density of Malassezia was shown on LS of SG than on NLS of SG and HC. M. slooffiae is the most prevalent species in SD patients in Serbia. This study demonstrated a positive relationship between severity of SD and presence of Malassezia spp.",
publisher = "Wiley, Hoboken",
journal = "Mycoses",
title = "Presence, species distribution, and density of Malassezia yeast in patients with seborrhoeic dermatitis - a community-based case-control study and review of literature",
volume = "58",
number = "2",
pages = "69-75",
doi = "10.1111/myc.12276"
}
Barac, A., Pekmezović, M., Milobratović, D., Otašević-Tasić, S., Radunović, M.,& Arsić-Arsenijević, V.. (2015). Presence, species distribution, and density of Malassezia yeast in patients with seborrhoeic dermatitis - a community-based case-control study and review of literature. in Mycoses
Wiley, Hoboken., 58(2), 69-75.
https://doi.org/10.1111/myc.12276
Barac A, Pekmezović M, Milobratović D, Otašević-Tasić S, Radunović M, Arsić-Arsenijević V. Presence, species distribution, and density of Malassezia yeast in patients with seborrhoeic dermatitis - a community-based case-control study and review of literature. in Mycoses. 2015;58(2):69-75.
doi:10.1111/myc.12276 .
Barac, Aleksandra, Pekmezović, Marina, Milobratović, Danica, Otašević-Tasić, Suzana, Radunović, Milena, Arsić-Arsenijević, Valentina, "Presence, species distribution, and density of Malassezia yeast in patients with seborrhoeic dermatitis - a community-based case-control study and review of literature" in Mycoses, 58, no. 2 (2015):69-75,
https://doi.org/10.1111/myc.12276 . .
1
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22

Evaluation of different sampling methods in patients with denture stomatitis

Perić, M.; Pucar, Ana; Živković, Rade; Radunović, Milena; Pavlica, Dušan; Arsić-Arsenijević, Valentina

(Wiley-Blackwell, Hoboken, 2014)

TY  - CONF
AU  - Perić, M.
AU  - Pucar, Ana
AU  - Živković, Rade
AU  - Radunović, Milena
AU  - Pavlica, Dušan
AU  - Arsić-Arsenijević, Valentina
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1927
PB  - Wiley-Blackwell, Hoboken
C3  - Oral Diseases
T1  - Evaluation of different sampling methods in patients with denture stomatitis
VL  - 20
SP  - 22
EP  - 22
UR  - https://hdl.handle.net/21.15107/rcub_smile_1927
ER  - 
@conference{
author = "Perić, M. and Pucar, Ana and Živković, Rade and Radunović, Milena and Pavlica, Dušan and Arsić-Arsenijević, Valentina",
year = "2014",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Evaluation of different sampling methods in patients with denture stomatitis",
volume = "20",
pages = "22-22",
url = "https://hdl.handle.net/21.15107/rcub_smile_1927"
}
Perić, M., Pucar, A., Živković, R., Radunović, M., Pavlica, D.,& Arsić-Arsenijević, V.. (2014). Evaluation of different sampling methods in patients with denture stomatitis. in Oral Diseases
Wiley-Blackwell, Hoboken., 20, 22-22.
https://hdl.handle.net/21.15107/rcub_smile_1927
Perić M, Pucar A, Živković R, Radunović M, Pavlica D, Arsić-Arsenijević V. Evaluation of different sampling methods in patients with denture stomatitis. in Oral Diseases. 2014;20:22-22.
https://hdl.handle.net/21.15107/rcub_smile_1927 .
Perić, M., Pucar, Ana, Živković, Rade, Radunović, Milena, Pavlica, Dušan, Arsić-Arsenijević, Valentina, "Evaluation of different sampling methods in patients with denture stomatitis" in Oral Diseases, 20 (2014):22-22,
https://hdl.handle.net/21.15107/rcub_smile_1927 .

Presence and quantification of Candida spp in diabetics and nondiabetics

Pucar, Ana; Matić-Petrović, Sanja; Radunović, Milena; Cimbaljević-Barac, M.; Kuzmanović-Pfićer, Jovana; Jotić, Aleksandra; Lalić, N.

(Wiley-Blackwell, Hoboken, 2014)

TY  - CONF
AU  - Pucar, Ana
AU  - Matić-Petrović, Sanja
AU  - Radunović, Milena
AU  - Cimbaljević-Barac, M.
AU  - Kuzmanović-Pfićer, Jovana
AU  - Jotić, Aleksandra
AU  - Lalić, N.
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1928
PB  - Wiley-Blackwell, Hoboken
C3  - Oral Diseases
T1  - Presence and quantification of Candida spp in diabetics and nondiabetics
VL  - 20
SP  - 19
EP  - 19
UR  - https://hdl.handle.net/21.15107/rcub_smile_1928
ER  - 
@conference{
author = "Pucar, Ana and Matić-Petrović, Sanja and Radunović, Milena and Cimbaljević-Barac, M. and Kuzmanović-Pfićer, Jovana and Jotić, Aleksandra and Lalić, N.",
year = "2014",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Presence and quantification of Candida spp in diabetics and nondiabetics",
volume = "20",
pages = "19-19",
url = "https://hdl.handle.net/21.15107/rcub_smile_1928"
}
Pucar, A., Matić-Petrović, S., Radunović, M., Cimbaljević-Barac, M., Kuzmanović-Pfićer, J., Jotić, A.,& Lalić, N.. (2014). Presence and quantification of Candida spp in diabetics and nondiabetics. in Oral Diseases
Wiley-Blackwell, Hoboken., 20, 19-19.
https://hdl.handle.net/21.15107/rcub_smile_1928
Pucar A, Matić-Petrović S, Radunović M, Cimbaljević-Barac M, Kuzmanović-Pfićer J, Jotić A, Lalić N. Presence and quantification of Candida spp in diabetics and nondiabetics. in Oral Diseases. 2014;20:19-19.
https://hdl.handle.net/21.15107/rcub_smile_1928 .
Pucar, Ana, Matić-Petrović, Sanja, Radunović, Milena, Cimbaljević-Barac, M., Kuzmanović-Pfićer, Jovana, Jotić, Aleksandra, Lalić, N., "Presence and quantification of Candida spp in diabetics and nondiabetics" in Oral Diseases, 20 (2014):19-19,
https://hdl.handle.net/21.15107/rcub_smile_1928 .