TY  - JOUR
AU  - Starčević, Ana
AU  - Poštić, Srđan
AU  - Radojicić, Zoran
AU  - Starčević, Branislav
AU  - Milovanović, Srđan
AU  - Ilanković, Andrej
AU  - Dimitrijević, Ivan
AU  - Damjanović, Aleksandar
AU  - Aksić, Milan
AU  - Radonjić, Vidosava
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1952
AB  - Objective. In our study we have hypothesized that volume changes of amygdala, hippocampus, and prefrontal cortex are more pronounced in male posttraumatic stress disorder participants. Material and Methods. We have conducted a study of 79 male participants who underwent MRI brain scanning. PTSD diagnosis was confirmed in 49 participants. After MRI was taken all scans were software based volume computed and statistically processed. Results. We found that left amygdala is the most significant parameter for distinction between PTSD participants and participants without PTSD. There were no significant differences in volumes of hippocampi and prefrontal cortices. Roc curve method outlined left amygdala AUC = 0.898 (95% CI = 0.830-0.967) and right amygdala AUC = 0.882 (95% CI = 0.810-0.954) in the group of PTSD participants which makes both variables highly statistically significant. Conclusion. The present investigation revealed significant volume decrease of left amygdala in PTSD patients. Concerning important functions of the amygdala and her neuroanatomical connections with other brain structures, we need to increase number of participants to clarify the correlation between impared amygdala and possible other different brain structures in participants with PTSD.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants
DO  - 10.1155/2014/968495
ER  - 

@article{
author = "Starčević, Ana and Poštić, Srđan and Radojicić, Zoran and Starčević, Branislav and Milovanović, Srđan and Ilanković, Andrej and Dimitrijević, Ivan and Damjanović, Aleksandar and Aksić, Milan and Radonjić, Vidosava",
year = "2014",
abstract = "Objective. In our study we have hypothesized that volume changes of amygdala, hippocampus, and prefrontal cortex are more pronounced in male posttraumatic stress disorder participants. Material and Methods. We have conducted a study of 79 male participants who underwent MRI brain scanning. PTSD diagnosis was confirmed in 49 participants. After MRI was taken all scans were software based volume computed and statistically processed. Results. We found that left amygdala is the most significant parameter for distinction between PTSD participants and participants without PTSD. There were no significant differences in volumes of hippocampi and prefrontal cortices. Roc curve method outlined left amygdala AUC = 0.898 (95% CI = 0.830-0.967) and right amygdala AUC = 0.882 (95% CI = 0.810-0.954) in the group of PTSD participants which makes both variables highly statistically significant. Conclusion. The present investigation revealed significant volume decrease of left amygdala in PTSD patients. Concerning important functions of the amygdala and her neuroanatomical connections with other brain structures, we need to increase number of participants to clarify the correlation between impared amygdala and possible other different brain structures in participants with PTSD.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants",
doi = "10.1155/2014/968495"
}

Starčević, A., Poštić, S., Radojicić, Z., Starčević, B., Milovanović, S., Ilanković, A., Dimitrijević, I., Damjanović, A., Aksić, M.,& Radonjić, V.. (2014). Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants. in Biomed Research International
Hindawi Ltd, London..
https://doi.org/10.1155/2014/968495

Starčević A, Poštić S, Radojicić Z, Starčević B, Milovanović S, Ilanković A, Dimitrijević I, Damjanović A, Aksić M, Radonjić V. Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants. in Biomed Research International. 2014;.
doi:10.1155/2014/968495 .

Starčević, Ana, Poštić, Srđan, Radojicić, Zoran, Starčević, Branislav, Milovanović, Srđan, Ilanković, Andrej, Dimitrijević, Ivan, Damjanović, Aleksandar, Aksić, Milan, Radonjić, Vidosava, "Volumetric Analysis of Amygdala, Hippocampus, and Prefrontal Cortex in Therapy-Naive PTSD Participants" in Biomed Research International (2014),
https://doi.org/10.1155/2014/968495 . .