Jovanović, T.

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  • Jovanović, T. (5)
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Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis

Jakovljević, Aleksandar; Knežević, Aleksandra; Nikolić, Nadja; Soldatović, Ivan; Jovanović, T.; Milašin, Jelena; Andrić, Miroslav

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Knežević, Aleksandra
AU  - Nikolić, Nadja
AU  - Soldatović, Ivan
AU  - Jovanović, T.
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2296
AB  - ObjectivesThis study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-, IL-1 and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. Materials and MethodsA total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-, IL-1 and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. ResultsThere were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p=.686, p=.879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. ConclusionThe observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis
VL  - 24
IS  - 5
SP  - 840
EP  - 846
DO  - 10.1111/odi.12829
ER  - 
@article{
author = "Jakovljević, Aleksandar and Knežević, Aleksandra and Nikolić, Nadja and Soldatović, Ivan and Jovanović, T. and Milašin, Jelena and Andrić, Miroslav",
year = "2018",
abstract = "ObjectivesThis study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-, IL-1 and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. Materials and MethodsA total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-, IL-1 and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. ResultsThere were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p=.686, p=.879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. ConclusionThe observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis",
volume = "24",
number = "5",
pages = "840-846",
doi = "10.1111/odi.12829"
}
Jakovljević, A., Knežević, A., Nikolić, N., Soldatović, I., Jovanović, T., Milašin, J.,& Andrić, M.. (2018). Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis. in Oral Diseases
Wiley, Hoboken., 24(5), 840-846.
https://doi.org/10.1111/odi.12829
Jakovljević A, Knežević A, Nikolić N, Soldatović I, Jovanović T, Milašin J, Andrić M. Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis. in Oral Diseases. 2018;24(5):840-846.
doi:10.1111/odi.12829 .
Jakovljević, Aleksandar, Knežević, Aleksandra, Nikolić, Nadja, Soldatović, Ivan, Jovanović, T., Milašin, Jelena, Andrić, Miroslav, "Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis" in Oral Diseases, 24, no. 5 (2018):840-846,
https://doi.org/10.1111/odi.12829 . .
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Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus

Jakovljević, Aleksandar; Andrić, Miroslav; Nikolić, Nadja; Corić, V.; Krezović, S.; Čarkić, Jelena; Knežević, Aleksandra; Beljić-Ivanović, Katarina; Pljesa-Ercegovac, M.; Miletić, Maja; Soldatović, Ivan; Radosavljević, T.; Jovanović, T.; Simić, T.; Ivanović, Vladimir; Milašin, Jelena

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Nikolić, Nadja
AU  - Corić, V.
AU  - Krezović, S.
AU  - Čarkić, Jelena
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Pljesa-Ercegovac, M.
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Radosavljević, T.
AU  - Jovanović, T.
AU  - Simić, T.
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2293
AB  - AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus
VL  - 51
IS  - 6
SP  - 593
EP  - 604
DO  - 10.1111/iej.12886
ER  - 
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Nikolić, Nadja and Corić, V. and Krezović, S. and Čarkić, Jelena and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Pljesa-Ercegovac, M. and Miletić, Maja and Soldatović, Ivan and Radosavljević, T. and Jovanović, T. and Simić, T. and Ivanović, Vladimir and Milašin, Jelena",
year = "2018",
abstract = "AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus",
volume = "51",
number = "6",
pages = "593-604",
doi = "10.1111/iej.12886"
}
Jakovljević, A., Andrić, M., Nikolić, N., Corić, V., Krezović, S., Čarkić, J., Knežević, A., Beljić-Ivanović, K., Pljesa-Ercegovac, M., Miletić, M., Soldatović, I., Radosavljević, T., Jovanović, T., Simić, T., Ivanović, V.,& Milašin, J.. (2018). Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal
Wiley, Hoboken., 51(6), 593-604.
https://doi.org/10.1111/iej.12886
Jakovljević A, Andrić M, Nikolić N, Corić V, Krezović S, Čarkić J, Knežević A, Beljić-Ivanović K, Pljesa-Ercegovac M, Miletić M, Soldatović I, Radosavljević T, Jovanović T, Simić T, Ivanović V, Milašin J. Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal. 2018;51(6):593-604.
doi:10.1111/iej.12886 .
Jakovljević, Aleksandar, Andrić, Miroslav, Nikolić, Nadja, Corić, V., Krezović, S., Čarkić, Jelena, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Pljesa-Ercegovac, M., Miletić, Maja, Soldatović, Ivan, Radosavljević, T., Jovanović, T., Simić, T., Ivanović, Vladimir, Milašin, Jelena, "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus" in International Endodontic Journal, 51, no. 6 (2018):593-604,
https://doi.org/10.1111/iej.12886 . .
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Presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy

Đurić, M.; Pavlica, Dušan; Janković, L.; Milašin, Jelena; Jovanović, T.

(Sage Publications Ltd, London, 2007)

TY  - JOUR
AU  - Đurić, M.
AU  - Pavlica, Dušan
AU  - Janković, L.
AU  - Milašin, Jelena
AU  - Jovanović, T.
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1344
AB  - Background The aim of this study was to confirm the presence of herpes simplex virus type 1 and 2 on the oral mucosa, in patients undergoing chemotherapy, by means of polymerase chain reaction (PCR). Methods The research was carried out on 40 patients receiving chemotherapy as treatment for different malignancies. The status of oral mucosa and viral presence were assessed in all patients at the initial examination (prior to chemotherapy), and at the control examination (two weeks after the initiation of the chemotherapeutic cycle). Results The presence of HSV-1 was detected in 28 patients (70%) prior to chemotherapy, of whom 7 (25%) manifested oral complications. The control examination showed the presence of HSV-1 in 35 patients (87.5%), of whom 23 (65.7%) presented oral mucosa changes. HSV-2 has not been detected in any of the patients.
PB  - Sage Publications Ltd, London
T2  - Scottish Medical Journal
T1  - Presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy
VL  - 52
IS  - 1
SP  - 28
EP  - 31
DO  - 10.1258/rsmsmj.52.1.28
ER  - 
@article{
author = "Đurić, M. and Pavlica, Dušan and Janković, L. and Milašin, Jelena and Jovanović, T.",
year = "2007",
abstract = "Background The aim of this study was to confirm the presence of herpes simplex virus type 1 and 2 on the oral mucosa, in patients undergoing chemotherapy, by means of polymerase chain reaction (PCR). Methods The research was carried out on 40 patients receiving chemotherapy as treatment for different malignancies. The status of oral mucosa and viral presence were assessed in all patients at the initial examination (prior to chemotherapy), and at the control examination (two weeks after the initiation of the chemotherapeutic cycle). Results The presence of HSV-1 was detected in 28 patients (70%) prior to chemotherapy, of whom 7 (25%) manifested oral complications. The control examination showed the presence of HSV-1 in 35 patients (87.5%), of whom 23 (65.7%) presented oral mucosa changes. HSV-2 has not been detected in any of the patients.",
publisher = "Sage Publications Ltd, London",
journal = "Scottish Medical Journal",
title = "Presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy",
volume = "52",
number = "1",
pages = "28-31",
doi = "10.1258/rsmsmj.52.1.28"
}
Đurić, M., Pavlica, D., Janković, L., Milašin, J.,& Jovanović, T.. (2007). Presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy. in Scottish Medical Journal
Sage Publications Ltd, London., 52(1), 28-31.
https://doi.org/10.1258/rsmsmj.52.1.28
Đurić M, Pavlica D, Janković L, Milašin J, Jovanović T. Presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy. in Scottish Medical Journal. 2007;52(1):28-31.
doi:10.1258/rsmsmj.52.1.28 .
Đurić, M., Pavlica, Dušan, Janković, L., Milašin, Jelena, Jovanović, T., "Presence of herpes simplex virus on the oral mucosa in patients undergoing chemotherapy" in Scottish Medical Journal, 52, no. 1 (2007):28-31,
https://doi.org/10.1258/rsmsmj.52.1.28 . .
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The application of tea tree essential oil in dentistry

Marković, Dejan; Mirković, B.; Jovanović, T.; Knežević, Aleksandra; Nastovski, T.

(Srpsko lekarsko društvo - Stomatološka sekcija, Beograd, 2007)

TY  - JOUR
AU  - Marković, Dejan
AU  - Mirković, B.
AU  - Jovanović, T.
AU  - Knežević, Aleksandra
AU  - Nastovski, T.
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1353
AB  - Essential oils are widely used in medicine, dentistry and cosmetology as flavour and odour corrigents in various substances for oral hygiene. The aim of this study was to present comprehensively the possibilities for application of Melaleuca Alternifolia essential oil in dentistry based on the analysis of contemporary scientific and professional publications. The application of Tea tree essential oil in the treatment of periodontal, fungal and viral diseases is very efficient. The study of antimicrobial potential of ten different essential oils confirmed the efficiency of Tea tree oil against numerous Gram+ and Gram- bacteria. In vitro studies of bacteriostatic, bactericidal and fungicidal effect of Tea tree oil solution against ten different microorganisms confirmed sensitivity of the following microorganisms: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Porphyromonas gingivalis, and slightly weaker effect against Streptococcus Mutans and Prevotella intermedia. Tea tree is very effective in the treatment of various diseases and is an introduction and momentum for the application of plant substances in the treatment of numerous diseases in dentistry. .
AB  - Etarska ulja imaju široku primenu u medicini, stomatologiji i kozmetologiji, kao korigensi ukusa i mirisa različitih sredstava za oralnu higijenu. Cilj ovog rada je bio da se kroz analizu aktuelnih naučnih i stručnih publikacija sveobuhvatno prikažu mogućnosti primene etarskog ulja Melaleuca Alternifolia u stomatologiji. Primena etarskog ulja čajnog drveta u lečenju parodontopatije, gljivičnih oboljenja, kao i u terapiji virusnih infekcija, se pokazala izuzetno efikasnom. Ispitivanjem antimikrobnog dejstva deset različitih etarskih ulja, potvrđeno je da je etarsko ulje čajnog drveta vrlo efikasno protiv niza Gram + i Gram - bakterija. In vitro ispitivanja bakteriostatskog, baktericidnog i fungicidnog delovanja rastvora ulja čajnog drveta na deset različitih mikroorganizama su potvrdila osetljivost sledećih mikroorganizama: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum i Porphyromonas gingivalis, i nešto slabije prema bakterijama Streptococcus Mutans i Prevotella intermedia. Čajno drvo se pokazalo izuzetno blagotvornim u lečenju različitih oboljenja i predstavlja uvod i podstrek za primenu biljnih preparata u lečenju brojnih manifestacija kod različitih oboljenja u stomatologiji. .
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - The application of tea tree essential oil in dentistry
T1  - Primena etarskog ulja čajnog drveta u stomatologiji
VL  - 54
IS  - 2
SP  - 106
EP  - 114
DO  - 10.2298/SGS0702106M
ER  - 
@article{
author = "Marković, Dejan and Mirković, B. and Jovanović, T. and Knežević, Aleksandra and Nastovski, T.",
year = "2007",
abstract = "Essential oils are widely used in medicine, dentistry and cosmetology as flavour and odour corrigents in various substances for oral hygiene. The aim of this study was to present comprehensively the possibilities for application of Melaleuca Alternifolia essential oil in dentistry based on the analysis of contemporary scientific and professional publications. The application of Tea tree essential oil in the treatment of periodontal, fungal and viral diseases is very efficient. The study of antimicrobial potential of ten different essential oils confirmed the efficiency of Tea tree oil against numerous Gram+ and Gram- bacteria. In vitro studies of bacteriostatic, bactericidal and fungicidal effect of Tea tree oil solution against ten different microorganisms confirmed sensitivity of the following microorganisms: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Porphyromonas gingivalis, and slightly weaker effect against Streptococcus Mutans and Prevotella intermedia. Tea tree is very effective in the treatment of various diseases and is an introduction and momentum for the application of plant substances in the treatment of numerous diseases in dentistry. ., Etarska ulja imaju široku primenu u medicini, stomatologiji i kozmetologiji, kao korigensi ukusa i mirisa različitih sredstava za oralnu higijenu. Cilj ovog rada je bio da se kroz analizu aktuelnih naučnih i stručnih publikacija sveobuhvatno prikažu mogućnosti primene etarskog ulja Melaleuca Alternifolia u stomatologiji. Primena etarskog ulja čajnog drveta u lečenju parodontopatije, gljivičnih oboljenja, kao i u terapiji virusnih infekcija, se pokazala izuzetno efikasnom. Ispitivanjem antimikrobnog dejstva deset različitih etarskih ulja, potvrđeno je da je etarsko ulje čajnog drveta vrlo efikasno protiv niza Gram + i Gram - bakterija. In vitro ispitivanja bakteriostatskog, baktericidnog i fungicidnog delovanja rastvora ulja čajnog drveta na deset različitih mikroorganizama su potvrdila osetljivost sledećih mikroorganizama: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum i Porphyromonas gingivalis, i nešto slabije prema bakterijama Streptococcus Mutans i Prevotella intermedia. Čajno drvo se pokazalo izuzetno blagotvornim u lečenju različitih oboljenja i predstavlja uvod i podstrek za primenu biljnih preparata u lečenju brojnih manifestacija kod različitih oboljenja u stomatologiji. .",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "The application of tea tree essential oil in dentistry, Primena etarskog ulja čajnog drveta u stomatologiji",
volume = "54",
number = "2",
pages = "106-114",
doi = "10.2298/SGS0702106M"
}
Marković, D., Mirković, B., Jovanović, T., Knežević, A.,& Nastovski, T.. (2007). The application of tea tree essential oil in dentistry. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 54(2), 106-114.
https://doi.org/10.2298/SGS0702106M
Marković D, Mirković B, Jovanović T, Knežević A, Nastovski T. The application of tea tree essential oil in dentistry. in Stomatološki glasnik Srbije. 2007;54(2):106-114.
doi:10.2298/SGS0702106M .
Marković, Dejan, Mirković, B., Jovanović, T., Knežević, Aleksandra, Nastovski, T., "The application of tea tree essential oil in dentistry" in Stomatološki glasnik Srbije, 54, no. 2 (2007):106-114,
https://doi.org/10.2298/SGS0702106M . .

Human cytomegalovirus is present in odontogenic cysts

Andrić, Miroslav; Milašin, Jelena; Jovanović, T.; Todorović, L.

(Blackwell Publishing, Oxford, 2007)

TY  - JOUR
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
AU  - Jovanović, T.
AU  - Todorović, L.
PY  - 2007
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1330
AB  - Introduction: Recent studies suggest that some viruses, including human cytomegalovirus (CMV), may be involved in the pathogenesis of periapical lesions. Since periapical cysts (PCs) represent the next stage in the evolution of periapical granuloma, it seemed reasonable to investigate the presence of CMV in PCs and any possible relationship between its presence and the clinical features of those cysts, as well as to compare the results obtained with corresponding findings in non-inflammatory lesions, like odontogenic keratocysts (OKCs). Methods: Samples of 33 PCs and 10 OKCs, obtained at the time of surgery, were used for the detection of CMV DNA by polymerase chain reaction. Presence of the virus was correlated with clinical and radiographic features of the cysts. Results: CMV was detected in 18 PCs (54.5%) and six OKCs (60%). The presence of CMV was more frequent in cyst samples collected from patients who reported previous episodes of acute infection. The presence of sinus tract was more frequent in CMV-positive cysts and CMV presence was less frequent in a group of cysts showing signs of acute inflammation at the time of sample collection. The mean sizes of CMV-positive and CMV-negative PCs were almost the same; CMV-positive OKCs were slightly larger than CMV-negative OKCs. None of these results proved to be statistically significant. Conclusion: The presence of CMV in the cystic wall is a common feature of both inflammatory and non-inflammatory odontogenic cysts. Although this study has not proved that CMV affects pathogenesis of odontogenic cysts, such a possibility could not be ruled out.
PB  - Blackwell Publishing, Oxford
T2  - Oral Microbiology & Immunology
T1  - Human cytomegalovirus is present in odontogenic cysts
VL  - 22
IS  - 5
SP  - 347
EP  - 351
DO  - 10.1111/j.1399-302X.2007.00369.x
ER  - 
@article{
author = "Andrić, Miroslav and Milašin, Jelena and Jovanović, T. and Todorović, L.",
year = "2007",
abstract = "Introduction: Recent studies suggest that some viruses, including human cytomegalovirus (CMV), may be involved in the pathogenesis of periapical lesions. Since periapical cysts (PCs) represent the next stage in the evolution of periapical granuloma, it seemed reasonable to investigate the presence of CMV in PCs and any possible relationship between its presence and the clinical features of those cysts, as well as to compare the results obtained with corresponding findings in non-inflammatory lesions, like odontogenic keratocysts (OKCs). Methods: Samples of 33 PCs and 10 OKCs, obtained at the time of surgery, were used for the detection of CMV DNA by polymerase chain reaction. Presence of the virus was correlated with clinical and radiographic features of the cysts. Results: CMV was detected in 18 PCs (54.5%) and six OKCs (60%). The presence of CMV was more frequent in cyst samples collected from patients who reported previous episodes of acute infection. The presence of sinus tract was more frequent in CMV-positive cysts and CMV presence was less frequent in a group of cysts showing signs of acute inflammation at the time of sample collection. The mean sizes of CMV-positive and CMV-negative PCs were almost the same; CMV-positive OKCs were slightly larger than CMV-negative OKCs. None of these results proved to be statistically significant. Conclusion: The presence of CMV in the cystic wall is a common feature of both inflammatory and non-inflammatory odontogenic cysts. Although this study has not proved that CMV affects pathogenesis of odontogenic cysts, such a possibility could not be ruled out.",
publisher = "Blackwell Publishing, Oxford",
journal = "Oral Microbiology & Immunology",
title = "Human cytomegalovirus is present in odontogenic cysts",
volume = "22",
number = "5",
pages = "347-351",
doi = "10.1111/j.1399-302X.2007.00369.x"
}
Andrić, M., Milašin, J., Jovanović, T.,& Todorović, L.. (2007). Human cytomegalovirus is present in odontogenic cysts. in Oral Microbiology & Immunology
Blackwell Publishing, Oxford., 22(5), 347-351.
https://doi.org/10.1111/j.1399-302X.2007.00369.x
Andrić M, Milašin J, Jovanović T, Todorović L. Human cytomegalovirus is present in odontogenic cysts. in Oral Microbiology & Immunology. 2007;22(5):347-351.
doi:10.1111/j.1399-302X.2007.00369.x .
Andrić, Miroslav, Milašin, Jelena, Jovanović, T., Todorović, L., "Human cytomegalovirus is present in odontogenic cysts" in Oral Microbiology & Immunology, 22, no. 5 (2007):347-351,
https://doi.org/10.1111/j.1399-302X.2007.00369.x . .
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