Andrić, Miroslav

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orcid::0000-0003-4136-7901
  • Andrić, Miroslav (37)

Author's Bibliography

Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review

Andrić, Miroslav; Jaćimović, Jelena; Jakovljević, Aleksandar; Nikolić, Nadja; Milašin, Jelena

(Wiley, 2021)

TY  - JOUR
AU  - Andrić, Miroslav
AU  - Jaćimović, Jelena
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2578
AB  - Objectives
The aim of this systematic review was to critically analyze available data on gene polymorphisms in odontogenic keratocysts (OKC) and ameloblastomas, including their possible relationship with clinical and histological features of these lesions.

Materials and Methods
A comprehensive search of Web of Science Scopus, PubMed, Cochrane Central Register of Controlled Trials and EMBASE was conducted using relevant key terms and supplemented by a gray literature search. Quality assessment of included studies was performed using criteria from the Strengthening the Reporting of Genetic Association (STREGA) statement.

Results
Ten studies were included in the final review. Survivin ‐31G/C, interleukin IL‐1α ‐889 C/T, p53 codon 72 G/C, tumor necrosis factor TNF‐α (−308G>A) and its receptor TNF‐R1 (36A>G), glioma‐associated oncogene homolog 1 rs2228224 and matrix metalloproteinase 2 rs243865 gene polymorphisms were reported to be associated with OKC. For ameloblastomas, p53 codon 72 G/C, X‐ray repair cross‐complementing protein 1—codons 194 and 399 and matrix metalloproteinase 9 rs3918242 gene polymorphisms were identified as risk factors. It was not possible to establish a relationship between specific polymorphisms and clinical and histological features of investigated lesions.

Conclusions
Several gene polymorphisms might be considered as a risk factor for the development of these lesions. Future studies should investigate whether these polymorphisms might be used to identify patients with increased risk of recurrence or aggressive disease.
PB  - Wiley
T2  - Oral Diseases
T1  - Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review
DO  - 10.1111/odi.13865
ER  - 
@article{
author = "Andrić, Miroslav and Jaćimović, Jelena and Jakovljević, Aleksandar and Nikolić, Nadja and Milašin, Jelena",
year = "2021",
abstract = "Objectives
The aim of this systematic review was to critically analyze available data on gene polymorphisms in odontogenic keratocysts (OKC) and ameloblastomas, including their possible relationship with clinical and histological features of these lesions.

Materials and Methods
A comprehensive search of Web of Science Scopus, PubMed, Cochrane Central Register of Controlled Trials and EMBASE was conducted using relevant key terms and supplemented by a gray literature search. Quality assessment of included studies was performed using criteria from the Strengthening the Reporting of Genetic Association (STREGA) statement.

Results
Ten studies were included in the final review. Survivin ‐31G/C, interleukin IL‐1α ‐889 C/T, p53 codon 72 G/C, tumor necrosis factor TNF‐α (−308G>A) and its receptor TNF‐R1 (36A>G), glioma‐associated oncogene homolog 1 rs2228224 and matrix metalloproteinase 2 rs243865 gene polymorphisms were reported to be associated with OKC. For ameloblastomas, p53 codon 72 G/C, X‐ray repair cross‐complementing protein 1—codons 194 and 399 and matrix metalloproteinase 9 rs3918242 gene polymorphisms were identified as risk factors. It was not possible to establish a relationship between specific polymorphisms and clinical and histological features of investigated lesions.

Conclusions
Several gene polymorphisms might be considered as a risk factor for the development of these lesions. Future studies should investigate whether these polymorphisms might be used to identify patients with increased risk of recurrence or aggressive disease.",
publisher = "Wiley",
journal = "Oral Diseases",
title = "Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review",
doi = "10.1111/odi.13865"
}
Andrić, M., Jaćimović, J., Jakovljević, A., Nikolić, N.,& Milašin, J.. (2021). Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review. in Oral Diseases
Wiley..
https://doi.org/10.1111/odi.13865
Andrić M, Jaćimović J, Jakovljević A, Nikolić N, Milašin J. Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review. in Oral Diseases. 2021;.
doi:10.1111/odi.13865 .
Andrić, Miroslav, Jaćimović, Jelena, Jakovljević, Aleksandar, Nikolić, Nadja, Milašin, Jelena, "Gene polymorphisms in odontogenic keratocysts and ameloblastomas: A systematic review" in Oral Diseases (2021),
https://doi.org/10.1111/odi.13865 . .
4
5
5

TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis

Jakovljević, Aleksandar; Nikolić, Nadja; Jaćimović, Jelena; Miletić, Maja; Andrić, Miroslav; Milašin, Jelena; Aminoshariae, Anita; Azarpazhooh, Amir

(Elsevier, 2021)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
AU  - Aminoshariae, Anita
AU  - Azarpazhooh, Amir
PY  - 2021
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2577
AB  - Introduction
This study aimed to perform a more precise estimation of the association between tumor necrosis factor-alpha (TNF-α) – 308 G/A single nucleotide polymorphism (SNP) and the risk of development of AP and its phenotypes based on all available published studies.
Methods
The study was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered in PROSPERO (CRD42020176190). The literature search was conducted via: Clarivate Analytics’ Scopus, PubMed, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases, from inception to December 2020 with no language restrictions. Two reviewers were involved independently in study selection, data extraction and appraising the studies that were included. The quality of included studies was evaluated using the Strengthening the Reporting of Genetic Association (STREGA) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Frequencies of genotypes and alleles of TNF-alpha (G>A 308, rs1800629) gene, with 95% Odds ratio was used.
Results
Four studies met the inclusion criteria with moderate risk of bias. This study revealed no significant association between TNF-α – 308 G/A SNP and AP, and the risk of AP development. Moreover, there was no significant association between genotype or allele frequency distribution and clinical manifestations (acute versus chronic) of AP. The certainty of evidence per GRADE was very low.
Conclusions
Due to very low certainty of evidence, whether there is an association between TNF-α – 308 G/A SNP and AP, warrants further well-designed multi-centric studies to adjudicate a better understanding of the role of genetic factors in the etiopathogenesis of AP.
PB  - Elsevier
T2  - Journal of Endodontics
T1  - TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis
DO  - 10.1016/j.joen.2021.03.007
ER  - 
@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena and Aminoshariae, Anita and Azarpazhooh, Amir",
year = "2021",
abstract = "Introduction
This study aimed to perform a more precise estimation of the association between tumor necrosis factor-alpha (TNF-α) – 308 G/A single nucleotide polymorphism (SNP) and the risk of development of AP and its phenotypes based on all available published studies.
Methods
The study was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is registered in PROSPERO (CRD42020176190). The literature search was conducted via: Clarivate Analytics’ Scopus, PubMed, Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure databases, from inception to December 2020 with no language restrictions. Two reviewers were involved independently in study selection, data extraction and appraising the studies that were included. The quality of included studies was evaluated using the Strengthening the Reporting of Genetic Association (STREGA) and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Frequencies of genotypes and alleles of TNF-alpha (G>A 308, rs1800629) gene, with 95% Odds ratio was used.
Results
Four studies met the inclusion criteria with moderate risk of bias. This study revealed no significant association between TNF-α – 308 G/A SNP and AP, and the risk of AP development. Moreover, there was no significant association between genotype or allele frequency distribution and clinical manifestations (acute versus chronic) of AP. The certainty of evidence per GRADE was very low.
Conclusions
Due to very low certainty of evidence, whether there is an association between TNF-α – 308 G/A SNP and AP, warrants further well-designed multi-centric studies to adjudicate a better understanding of the role of genetic factors in the etiopathogenesis of AP.",
publisher = "Elsevier",
journal = "Journal of Endodontics",
title = "TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis",
doi = "10.1016/j.joen.2021.03.007"
}
Jakovljević, A., Nikolić, N., Jaćimović, J., Miletić, M., Andrić, M., Milašin, J., Aminoshariae, A.,& Azarpazhooh, A.. (2021). TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis. in Journal of Endodontics
Elsevier..
https://doi.org/10.1016/j.joen.2021.03.007
Jakovljević A, Nikolić N, Jaćimović J, Miletić M, Andrić M, Milašin J, Aminoshariae A, Azarpazhooh A. TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis. in Journal of Endodontics. 2021;.
doi:10.1016/j.joen.2021.03.007 .
Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, Aminoshariae, Anita, Azarpazhooh, Amir, "TNF-α -308 G/A single nucleotide polymorphism and apical periodontitis: an updated systematic review and meta-analysis" in Journal of Endodontics (2021),
https://doi.org/10.1016/j.joen.2021.03.007 . .
12

Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020

Jakovljević, Aleksandar; Nikolić, Nadja; Jaćimović, Jelena; Pavlović, Ognjan; Miličić, Biljana; Beljić-Ivanović, Katarina; Miletić, Maja; Andrić, Miroslav; Milašin, Jelena

(Elsevier Inc., 2020)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2570
AB  - Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386.e8
DO  - 10.1016/j.joen.2020.07.007
ER  - 
@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
 This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.
 
 Methods
 An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.
 
 Results
 Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.
 
 Conclusions
 There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386.e8",
doi = "10.1016/j.joen.2020.07.007"
}
Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.e8.
https://doi.org/10.1016/j.joen.2020.07.007
Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.e8.
doi:10.1016/j.joen.2020.07.007 .
Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386.e8,
https://doi.org/10.1016/j.joen.2020.07.007 . .
1
102
24
93

Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020

Jakovljević, Aleksandar; Nikolić, Nadja; Jaćimović, Jelena; Pavlović, Ognjan; Miličić, Biljana; Beljić-Ivanović, Katarina; Miletić, Maja; Andrić, Miroslav; Milašin, Jelena

(Elsevier Inc., 2020)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Jaćimović, Jelena
AU  - Pavlović, Ognjan
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2531
AB  - Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.
PB  - Elsevier Inc.
T2  - Journal of Endodontics
T1  - Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020
VL  - 46
IS  - 10
SP  - 1371
EP  - 1386
DO  - 10.1016/j.joen.2020.07.007
ER  - 
@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Jaćimović, Jelena and Pavlović, Ognjan and Miličić, Biljana and Beljić-Ivanović, Katarina and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Introduction
This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods
An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.

Results
Sixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.

Conclusions
There is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment.",
publisher = "Elsevier Inc.",
journal = "Journal of Endodontics",
title = "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020",
volume = "46",
number = "10",
pages = "1371-1386",
doi = "10.1016/j.joen.2020.07.007"
}
Jakovljević, A., Nikolić, N., Jaćimović, J., Pavlović, O., Miličić, B., Beljić-Ivanović, K., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics
Elsevier Inc.., 46(10), 1371-1386.
https://doi.org/10.1016/j.joen.2020.07.007
Jakovljević A, Nikolić N, Jaćimović J, Pavlović O, Miličić B, Beljić-Ivanović K, Miletić M, Andrić M, Milašin J. Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020. in Journal of Endodontics. 2020;46(10):1371-1386.
doi:10.1016/j.joen.2020.07.007 .
Jakovljević, Aleksandar, Nikolić, Nadja, Jaćimović, Jelena, Pavlović, Ognjan, Miličić, Biljana, Beljić-Ivanović, Katarina, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020" in Journal of Endodontics, 46, no. 10 (2020):1371-1386,
https://doi.org/10.1016/j.joen.2020.07.007 . .
1
102
24
93

Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis

Jakovljević, Aleksandar; Nikolić, Nadja; Čarkić, Jelena; Andrić, Miroslav; Miletić, Maja; Beljić-Ivanović, Katarina; Jovanović, Tanja; Milašin, Jelena

(Taylor & Francis Ltd, Abingdon, 2020)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Jovanović, Tanja
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2493
AB  - Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Acta Odontologica Scandinavica
T1  - Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis
VL  - 78
IS  - 2
SP  - 126
EP  - 131
DO  - 10.1080/00016357.2019.1658896
ER  - 
@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Jovanović, Tanja and Milašin, Jelena",
year = "2020",
abstract = "Objectives: This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-? ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-?), interleukin-1 beta (IL-1?) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Materials and methods: Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure. The presence of EBV was determined using nested PCR. Based on the presence of EBV all periapical lesions were divided into two groups, 29 EBV positive and 35 EBV negative lesions. A reverse transcriptase real-time PCR was used to determine mRNA levels of Notch2, Jagged1, RANKL, OPG, TNF-?, IL-1? and IL-6. Results: Significantly higher mRNA levels of Notch2, Jagged1, RANKL and IL-1? were observed in EBV positive compared to EBV negative lesions. Significant positive correlation was present between Notch2 and Jagged1, Jagged1 and RANKL, and IL-? and TNF-? in EBV positive periapical lesions. Conclusions: Notch signalling pathway may be involved in alveolar bone resorption in apical periodontitis lesions infected by EBV.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Acta Odontologica Scandinavica",
title = "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis",
volume = "78",
number = "2",
pages = "126-131",
doi = "10.1080/00016357.2019.1658896"
}
Jakovljević, A., Nikolić, N., Čarkić, J., Andrić, M., Miletić, M., Beljić-Ivanović, K., Jovanović, T.,& Milašin, J.. (2020). Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica
Taylor & Francis Ltd, Abingdon., 78(2), 126-131.
https://doi.org/10.1080/00016357.2019.1658896
Jakovljević A, Nikolić N, Čarkić J, Andrić M, Miletić M, Beljić-Ivanović K, Jovanović T, Milašin J. Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis. in Acta Odontologica Scandinavica. 2020;78(2):126-131.
doi:10.1080/00016357.2019.1658896 .
Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Jovanović, Tanja, Milašin, Jelena, "Notch ? a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis" in Acta Odontologica Scandinavica, 78, no. 2 (2020):126-131,
https://doi.org/10.1080/00016357.2019.1658896 . .
1
14
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Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?

Jakovljević, Aleksandar; Nikolić, Nadja; Čarkić, Jelena; Beljić-Ivanović, Katarina; Soldatović, Ivan; Miletić, Maja; Andrić, Miroslav; Milašin, Jelena

(Wiley, Hoboken, 2020)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Nikolić, Nadja
AU  - Čarkić, Jelena
AU  - Beljić-Ivanović, Katarina
AU  - Soldatović, Ivan
AU  - Miletić, Maja
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1047
AB  - Aim To investigate the possible association between TNF alpha (-308 G/A) and IL-1 beta (-511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF-alpha and IL-1 beta was analysed using reverse transcriptase - real-time PCR. The presence of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi-square and Fisher's exact tests and logistic regression analyses were done for polymorphisms, whilst Mann-Whitney U-test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy-Weinberg equilibrium test. Results TNF-alpha (-308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06-2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77-41.36, P  lt  0.001) carriers of the variant A allele. On the other hand, IL-1 beta (-511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332-0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026-0.501, P  lt  0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P  lt  0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein-Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1-4.71, P = 0.048), whilst TNF-alpha SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08-0.48, P  lt  0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01-0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNF alpha (-308 G/A) SNP, are associated with increased risk, whereas IL-1 beta (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNF alpha polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?
VL  - 53
IS  - 7
SP  - 895
EP  - 904
DO  - 10.1111/iej.13298
ER  - 
@article{
author = "Jakovljević, Aleksandar and Nikolić, Nadja and Čarkić, Jelena and Beljić-Ivanović, Katarina and Soldatović, Ivan and Miletić, Maja and Andrić, Miroslav and Milašin, Jelena",
year = "2020",
abstract = "Aim To investigate the possible association between TNF alpha (-308 G/A) and IL-1 beta (-511 C/T) single nucleotide polymorphisms (SNPs) and GSTT and GSTM deletion polymorphisms and risk of apical periodontitis (AP) development, and determine the association of different genotypes with the presence of herpesviral infection in AP. Methodology The study included 120 periapical lesions and 200 control samples. Gene polymorphism analysis was performed using either polymerase chain reaction (PCR) or PCR/ restriction fragment length polymorphism (RFLP). Relative gene expression of TNF-alpha and IL-1 beta was analysed using reverse transcriptase - real-time PCR. The presence of Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by nested PCR. Chi-square and Fisher's exact tests and logistic regression analyses were done for polymorphisms, whilst Mann-Whitney U-test was performed for the expression analysis. The expected frequency of variants was analysed by the Hardy-Weinberg equilibrium test. Results TNF-alpha (-308 G/A) SNP increased AP susceptibility for heterozygous (odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.06-2.80, P = 0.027) and homozygous (OR = 8.55, 95% CI = 1.77-41.36, P  lt  0.001) carriers of the variant A allele. On the other hand, IL-1 beta (-511 C/T) polymorphism exerted a protective effect both in heterozygotes (OR = 0.540, 95% CI = 0.332-0.880, P = 0.013) and homozygotes (OR = 0.114, 95% CI = 0.026-0.501, P  lt  0.001). In addition, GSTM1 and GSTT1 null genotypes separately, as well as concomitantly, were associated with an increased risk for AP development (P  lt  0.001). The null GSTT1 genotype increased approximately twice the risk of Epstein-Barr infection (EBV) in AP (OR = 2.17, 95% CI = 1-4.71, P = 0.048), whilst TNF-alpha SNP decreased it, both in heterozygotes (OR = 0.20, 95% CI = 0.08-0.48, P  lt  0.001) and AA homozygotes (OR = 0.07, 95% CI = 0.01-0.37, P = 0.001). Conclusions GSTM and GSTT deletion polymorphisms, as well as TNF alpha (-308 G/A) SNP, are associated with increased risk, whereas IL-1 beta (-511 C/T) polymorphism decreases the risk of AP development. GSTT and TNF alpha polymorphisms also appear to modulate the risk of EBV infection in Serbian patients with AP.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?",
volume = "53",
number = "7",
pages = "895-904",
doi = "10.1111/iej.13298"
}
Jakovljević, A., Nikolić, N., Čarkić, J., Beljić-Ivanović, K., Soldatović, I., Miletić, M., Andrić, M.,& Milašin, J.. (2020). Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?. in International Endodontic Journal
Wiley, Hoboken., 53(7), 895-904.
https://doi.org/10.1111/iej.13298
Jakovljević A, Nikolić N, Čarkić J, Beljić-Ivanović K, Soldatović I, Miletić M, Andrić M, Milašin J. Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?. in International Endodontic Journal. 2020;53(7):895-904.
doi:10.1111/iej.13298 .
Jakovljević, Aleksandar, Nikolić, Nadja, Čarkić, Jelena, Beljić-Ivanović, Katarina, Soldatović, Ivan, Miletić, Maja, Andrić, Miroslav, Milašin, Jelena, "Association of polymorphisms in TNF-alpha, IL-1 beta, GSTM and GSTT genes with apical periodontitis: is there a link with herpesviral infection?" in International Endodontic Journal, 53, no. 7 (2020):895-904,
https://doi.org/10.1111/iej.13298 . .
18
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16

Endodontic Periapical Disease: A Virus-Based Perspective

Sabeti, Mohammad; Golchert, Kory J.; Shirgill, Neveed; Jakovljević, Aleksandar; Andrić, Miroslav; Milašin, Jelena

(Iris Publishers, 2019)

TY  - JOUR
AU  - Sabeti, Mohammad
AU  - Golchert, Kory J.
AU  - Shirgill, Neveed
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2583
AB  - There is a need for updating the current treatment modalities for periapical lesions of endodontic origin to reflect the contributions and potential morbidity from herpesvirus infection. Herpesviruses, particularly human cytomegalovirus and Epstein-Barr virus, play an important role in the symptomatic periapical lesion. Indeed, periapical lesions may remain stable and silent until they become symptomatic, possibly triggered by the activation of latent herpesviruses within the lesion itself. Given the potential for grave systemic conditions associated with herpesvirus infection, early detection and treatment decisions for periapical lesions by the dentist may positively affect a patient’s overall health; especially for the immunocompromised patient.
PB  - Iris Publishers
T2  - Online Journal of Dentistry & Oral Health
T1  - Endodontic Periapical Disease: A Virus-Based Perspective
VL  - 2
IS  - 2
SP  - 1
EP  - 5
DO  - 10.33552/OJDOH.2019.02.000534
ER  - 
@article{
author = "Sabeti, Mohammad and Golchert, Kory J. and Shirgill, Neveed and Jakovljević, Aleksandar and Andrić, Miroslav and Milašin, Jelena",
year = "2019",
abstract = "There is a need for updating the current treatment modalities for periapical lesions of endodontic origin to reflect the contributions and potential morbidity from herpesvirus infection. Herpesviruses, particularly human cytomegalovirus and Epstein-Barr virus, play an important role in the symptomatic periapical lesion. Indeed, periapical lesions may remain stable and silent until they become symptomatic, possibly triggered by the activation of latent herpesviruses within the lesion itself. Given the potential for grave systemic conditions associated with herpesvirus infection, early detection and treatment decisions for periapical lesions by the dentist may positively affect a patient’s overall health; especially for the immunocompromised patient.",
publisher = "Iris Publishers",
journal = "Online Journal of Dentistry & Oral Health",
title = "Endodontic Periapical Disease: A Virus-Based Perspective",
volume = "2",
number = "2",
pages = "1-5",
doi = "10.33552/OJDOH.2019.02.000534"
}
Sabeti, M., Golchert, K. J., Shirgill, N., Jakovljević, A., Andrić, M.,& Milašin, J.. (2019). Endodontic Periapical Disease: A Virus-Based Perspective. in Online Journal of Dentistry & Oral Health
Iris Publishers., 2(2), 1-5.
https://doi.org/10.33552/OJDOH.2019.02.000534
Sabeti M, Golchert KJ, Shirgill N, Jakovljević A, Andrić M, Milašin J. Endodontic Periapical Disease: A Virus-Based Perspective. in Online Journal of Dentistry & Oral Health. 2019;2(2):1-5.
doi:10.33552/OJDOH.2019.02.000534 .
Sabeti, Mohammad, Golchert, Kory J., Shirgill, Neveed, Jakovljević, Aleksandar, Andrić, Miroslav, Milašin, Jelena, "Endodontic Periapical Disease: A Virus-Based Perspective" in Online Journal of Dentistry & Oral Health, 2, no. 2 (2019):1-5,
https://doi.org/10.33552/OJDOH.2019.02.000534 . .

Notch signaling pathway mediates alveolar bone resorption in apical periodontitis

Jakovljević, Aleksandar; Miletić, Maja; Nikolić, Nadja; Beljić-Ivanović, Katarina; Andrić, Miroslav; Milašin, Jelena

(Churchill Livingstone, Edinburgh, 2019)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Miletić, Maja
AU  - Nikolić, Nadja
AU  - Beljić-Ivanović, Katarina
AU  - Andrić, Miroslav
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2455
AB  - Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Notch signaling pathway mediates alveolar bone resorption in apical periodontitis
VL  - 124
SP  - 87
EP  - 90
DO  - 10.1016/j.mehy.2019.02.018
ER  - 
@article{
author = "Jakovljević, Aleksandar and Miletić, Maja and Nikolić, Nadja and Beljić-Ivanović, Katarina and Andrić, Miroslav and Milašin, Jelena",
year = "2019",
abstract = "Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis",
volume = "124",
pages = "87-90",
doi = "10.1016/j.mehy.2019.02.018"
}
Jakovljević, A., Miletić, M., Nikolić, N., Beljić-Ivanović, K., Andrić, M.,& Milašin, J.. (2019). Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 124, 87-90.
https://doi.org/10.1016/j.mehy.2019.02.018
Jakovljević A, Miletić M, Nikolić N, Beljić-Ivanović K, Andrić M, Milašin J. Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses. 2019;124:87-90.
doi:10.1016/j.mehy.2019.02.018 .
Jakovljević, Aleksandar, Miletić, Maja, Nikolić, Nadja, Beljić-Ivanović, Katarina, Andrić, Miroslav, Milašin, Jelena, "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis" in Medical Hypotheses, 124 (2019):87-90,
https://doi.org/10.1016/j.mehy.2019.02.018 . .
16
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18

Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines

Nikolić, Nadja; Jakovljević, Aleksandar; Čarkić, Jelena; Beljić-Ivanović, Katarina; Miletić, Maja; Soldatović, Ivan; Andrić, Miroslav; Ivanović, Vladimir; Milašin, Jelena

(Elsevier Science Inc, New York, 2019)

TY  - JOUR
AU  - Nikolić, Nadja
AU  - Jakovljević, Aleksandar
AU  - Čarkić, Jelena
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Andrić, Miroslav
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2390
AB  - Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-1 beta, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteo-protegerin (OPG) ratios and determine their potential correlation. Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. The relative gene expression of the investigated molecules (Notch2, Jagged1, Hey1, RANKL, OPG, TNF-alpha, IL-1 beta, and IL-6) in all tissue samples was analyzed using reverse transcriptase real-time polymerase chain reaction. The Student t test, Mann-Whitney U test and Spearman correlation were used for statistical analysis. Results: Based on the RANKUOPG ratio, periapical lesions were either RANKL predominant (RANKL > OPG, n = 33) or OPG predominant (RANKL  lt  OPG, n = 17). Symptomatic lesions occurred more frequently in RANKL-predominant compared with OPG-predominant lesions (24 vs 7, P=.029). Notch2,Jagged1, Hey1, and TNF-alpha were significantly overexpressed in lesions with predominant RANKL compared with lesions with predominant OPG (P =.001, P =.001, P =.027, and P =.016, respectively). Significant correlations were observed between the investigated genes in periapical lesions. Conclusions: Notch signaling appeared to be activated in periapical inflammation. An increase in Notch2, Jagged1, Hey1, and TNF-alpha expression in RANKL-predominant periapical lesions corroborates their joined involvement in extensive periapical bone resorption.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines
VL  - 45
IS  - 2
SP  - 123
EP  - 128
DO  - 10.1016/j.joen.2018.10.015
ER  - 
@article{
author = "Nikolić, Nadja and Jakovljević, Aleksandar and Čarkić, Jelena and Beljić-Ivanović, Katarina and Miletić, Maja and Soldatović, Ivan and Andrić, Miroslav and Ivanović, Vladimir and Milašin, Jelena",
year = "2019",
abstract = "Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-alpha], interleukin [IL]-1 beta, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteo-protegerin (OPG) ratios and determine their potential correlation. Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy. The relative gene expression of the investigated molecules (Notch2, Jagged1, Hey1, RANKL, OPG, TNF-alpha, IL-1 beta, and IL-6) in all tissue samples was analyzed using reverse transcriptase real-time polymerase chain reaction. The Student t test, Mann-Whitney U test and Spearman correlation were used for statistical analysis. Results: Based on the RANKUOPG ratio, periapical lesions were either RANKL predominant (RANKL > OPG, n = 33) or OPG predominant (RANKL  lt  OPG, n = 17). Symptomatic lesions occurred more frequently in RANKL-predominant compared with OPG-predominant lesions (24 vs 7, P=.029). Notch2,Jagged1, Hey1, and TNF-alpha were significantly overexpressed in lesions with predominant RANKL compared with lesions with predominant OPG (P =.001, P =.001, P =.027, and P =.016, respectively). Significant correlations were observed between the investigated genes in periapical lesions. Conclusions: Notch signaling appeared to be activated in periapical inflammation. An increase in Notch2, Jagged1, Hey1, and TNF-alpha expression in RANKL-predominant periapical lesions corroborates their joined involvement in extensive periapical bone resorption.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines",
volume = "45",
number = "2",
pages = "123-128",
doi = "10.1016/j.joen.2018.10.015"
}
Nikolić, N., Jakovljević, A., Čarkić, J., Beljić-Ivanović, K., Miletić, M., Soldatović, I., Andrić, M., Ivanović, V.,& Milašin, J.. (2019). Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. in Journal of Endodontics
Elsevier Science Inc, New York., 45(2), 123-128.
https://doi.org/10.1016/j.joen.2018.10.015
Nikolić N, Jakovljević A, Čarkić J, Beljić-Ivanović K, Miletić M, Soldatović I, Andrić M, Ivanović V, Milašin J. Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. in Journal of Endodontics. 2019;45(2):123-128.
doi:10.1016/j.joen.2018.10.015 .
Nikolić, Nadja, Jakovljević, Aleksandar, Čarkić, Jelena, Beljić-Ivanović, Katarina, Miletić, Maja, Soldatović, Ivan, Andrić, Miroslav, Ivanović, Vladimir, Milašin, Jelena, "Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines" in Journal of Endodontics, 45, no. 2 (2019):123-128,
https://doi.org/10.1016/j.joen.2018.10.015 . .
1
32
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28

Herpesviral Infection in Periapical Periodontitis

Jakovljević, Aleksandar; Andrić, Miroslav; Knežević, Aleksandra; Miletić, Maja; Beljić-Ivanović, Katarina; Milašin, Jelena; Sabeti, Mohammad

(Springer, 2018)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Sabeti, Mohammad
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2595
AB  - Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.
PB  - Springer
T2  - Current Oral Health Reports
T1  - Herpesviral Infection in Periapical Periodontitis
VL  - 5
IS  - 4
SP  - 255
EP  - 263
DO  - 10.1007/s40496-018-0198-7
ER  - 
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Sabeti, Mohammad",
year = "2018",
abstract = "Purpose of Review
This review describes the most recent findings on herpesviral infections and offers current concepts of herpesviral role in the pathogenesis of periapical periodontitis.

Recent Findings
Thirty articles reported data on herpesviral infection in periapical periodontitis. Epstein-Barr virus and human cytomegalovirus are the most frequently detected herpesviruses in periapical samples. The main hypothesis postulates a bidirectional herpesviral-bacterial relationship in the etiopathogenesis of periapical periodontitis. A high heterogeneity of herpesviruses incidence was registered within the studies, in part, due to various methodological approaches used in laboratory testing, different inclusion criteria, study design, seroprevalence of herpesviruses, and sociodemographic characteristics of investigated populations.

Summary
Herpesviruses have been shown to potentially impair local host defense in periapical tissue. Although it has been demonstrated that endodontic pathogenic bacteria are able to reactivate herpesviruses, further, in vitro studies should provide more data on herpesviruses as a factor in the pathogenesis of the periapical pathoses. It is, therefore, necessary to investigate potential benefits of antiviral therapy in well-designed controlled longitudinal studies.",
publisher = "Springer",
journal = "Current Oral Health Reports",
title = "Herpesviral Infection in Periapical Periodontitis",
volume = "5",
number = "4",
pages = "255-263",
doi = "10.1007/s40496-018-0198-7"
}
Jakovljević, A., Andrić, M., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Sabeti, M.. (2018). Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports
Springer., 5(4), 255-263.
https://doi.org/10.1007/s40496-018-0198-7
Jakovljević A, Andrić M, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Sabeti M. Herpesviral Infection in Periapical Periodontitis. in Current Oral Health Reports. 2018;5(4):255-263.
doi:10.1007/s40496-018-0198-7 .
Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Sabeti, Mohammad, "Herpesviral Infection in Periapical Periodontitis" in Current Oral Health Reports, 5, no. 4 (2018):255-263,
https://doi.org/10.1007/s40496-018-0198-7 . .
10
10

Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis

Jakovljević, Aleksandar; Knežević, Aleksandra; Nikolić, Nadja; Soldatović, Ivan; Jovanović, T.; Milašin, Jelena; Andrić, Miroslav

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Knežević, Aleksandra
AU  - Nikolić, Nadja
AU  - Soldatović, Ivan
AU  - Jovanović, T.
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2296
AB  - ObjectivesThis study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-, IL-1 and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. Materials and MethodsA total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-, IL-1 and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. ResultsThere were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p=.686, p=.879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. ConclusionThe observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.
PB  - Wiley, Hoboken
T2  - Oral Diseases
T1  - Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis
VL  - 24
IS  - 5
SP  - 840
EP  - 846
DO  - 10.1111/odi.12829
ER  - 
@article{
author = "Jakovljević, Aleksandar and Knežević, Aleksandra and Nikolić, Nadja and Soldatović, Ivan and Jovanović, T. and Milašin, Jelena and Andrić, Miroslav",
year = "2018",
abstract = "ObjectivesThis study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-, IL-1 and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. Materials and MethodsA total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-, IL-1 and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. ResultsThere were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p=.686, p=.879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. ConclusionThe observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.",
publisher = "Wiley, Hoboken",
journal = "Oral Diseases",
title = "Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis",
volume = "24",
number = "5",
pages = "840-846",
doi = "10.1111/odi.12829"
}
Jakovljević, A., Knežević, A., Nikolić, N., Soldatović, I., Jovanović, T., Milašin, J.,& Andrić, M.. (2018). Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis. in Oral Diseases
Wiley, Hoboken., 24(5), 840-846.
https://doi.org/10.1111/odi.12829
Jakovljević A, Knežević A, Nikolić N, Soldatović I, Jovanović T, Milašin J, Andrić M. Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis. in Oral Diseases. 2018;24(5):840-846.
doi:10.1111/odi.12829 .
Jakovljević, Aleksandar, Knežević, Aleksandra, Nikolić, Nadja, Soldatović, Ivan, Jovanović, T., Milašin, Jelena, Andrić, Miroslav, "Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis" in Oral Diseases, 24, no. 5 (2018):840-846,
https://doi.org/10.1111/odi.12829 . .
19
11
21

Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus

Jakovljević, Aleksandar; Andrić, Miroslav; Nikolić, Nadja; Corić, V.; Krezović, S.; Čarkić, Jelena; Knežević, Aleksandra; Beljić-Ivanović, Katarina; Pljesa-Ercegovac, M.; Miletić, Maja; Soldatović, Ivan; Radosavljević, T.; Jovanović, T.; Simić, T.; Ivanović, Vladimir; Milašin, Jelena

(Wiley, Hoboken, 2018)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Nikolić, Nadja
AU  - Corić, V.
AU  - Krezović, S.
AU  - Čarkić, Jelena
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Pljesa-Ercegovac, M.
AU  - Miletić, Maja
AU  - Soldatović, Ivan
AU  - Radosavljević, T.
AU  - Jovanović, T.
AU  - Simić, T.
AU  - Ivanović, Vladimir
AU  - Milašin, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2293
AB  - AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus
VL  - 51
IS  - 6
SP  - 593
EP  - 604
DO  - 10.1111/iej.12886
ER  - 
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Nikolić, Nadja and Corić, V. and Krezović, S. and Čarkić, Jelena and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Pljesa-Ercegovac, M. and Miletić, Maja and Soldatović, Ivan and Radosavljević, T. and Jovanović, T. and Simić, T. and Ivanović, Vladimir and Milašin, Jelena",
year = "2018",
abstract = "AimTo investigate whether apical periodontitis lesions infected by Epstein-Barr virus (EBV) exhibit higher levels of oxidative stress biomarkers [8-hydroxydeoxyguanosine (8-OHdG) and oxidized glutathione (GSSG)] and bone resorption regulators [receptor activator of nuclear factor (NF-B) ligand (RANKL) and osteoprotegerin (OPG)] compared to EBV-negative periapical lesions and healthy pulp tissues. MethodologyThe experimental group consisted of 30 EBV-positive and 30 EBV-negative periapical lesions collected in conjunction with apicoectomy. The pulp tissues of 20 impacted third molars were used as healthy controls. The qualitative and quantitative analysis of EBV was performed by nested and real-time polymerase chain reaction (PCR), respectively. The levels of RANKL and OPG were analysed by reverse transcriptase real-time PCR. The levels of 8-OHdG and GSSG were determined by enzyme-linked immunosorbent assay (ELISA). Mann-Whitney U-test and Spearman's correlation were used for statistical analysis. ResultsThe levels of RANKL, OPG, 8-OHdG and GSSG were significantly higher in apical periodontitis lesions compared to healthy pulp controls (P=0.001, P lt 0.001, P lt 0.001 and P lt 0.05, respectively). RANKL and OPG mRNA expression was significantly higher in EBV-positive compared to EBV-negative periapical lesions (P lt 0.05). There was no significant correlation between EBV copy numbers and levels of RANKL, OPG, 8OH-dG and GSSG in apical periodontitis. ConclusionLevels of bone resorption regulators and oxidative stress biomarkers were increased in apical periodontitis compared to healthy pulp tissues. EBV-positive periapical lesions exhibited higher levels of RANKL and OPG compared to EBV-negative periapical lesions. EBV may contribute to progression of apical periodontitis via enhanced production of bone resorption regulators.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus",
volume = "51",
number = "6",
pages = "593-604",
doi = "10.1111/iej.12886"
}
Jakovljević, A., Andrić, M., Nikolić, N., Corić, V., Krezović, S., Čarkić, J., Knežević, A., Beljić-Ivanović, K., Pljesa-Ercegovac, M., Miletić, M., Soldatović, I., Radosavljević, T., Jovanović, T., Simić, T., Ivanović, V.,& Milašin, J.. (2018). Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal
Wiley, Hoboken., 51(6), 593-604.
https://doi.org/10.1111/iej.12886
Jakovljević A, Andrić M, Nikolić N, Corić V, Krezović S, Čarkić J, Knežević A, Beljić-Ivanović K, Pljesa-Ercegovac M, Miletić M, Soldatović I, Radosavljević T, Jovanović T, Simić T, Ivanović V, Milašin J. Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. in International Endodontic Journal. 2018;51(6):593-604.
doi:10.1111/iej.12886 .
Jakovljević, Aleksandar, Andrić, Miroslav, Nikolić, Nadja, Corić, V., Krezović, S., Čarkić, Jelena, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Pljesa-Ercegovac, M., Miletić, Maja, Soldatović, Ivan, Radosavljević, T., Jovanović, T., Simić, T., Ivanović, Vladimir, Milašin, Jelena, "Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus" in International Endodontic Journal, 51, no. 6 (2018):593-604,
https://doi.org/10.1111/iej.12886 . .
22
13
21

TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development

Ilić, Branislav; Nikolić, Nadja; Andrić, Miroslav; Jelovac, Drago; Miličić, Biljana; Jozić, Tanja; Krstić, Slobodan; Milašin, Jelena

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Ilić, Branislav
AU  - Nikolić, Nadja
AU  - Andrić, Miroslav
AU  - Jelovac, Drago
AU  - Miličić, Biljana
AU  - Jozić, Tanja
AU  - Krstić, Slobodan
AU  - Milašin, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2190
AB  - BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P  lt  0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P  lt  0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.
PB  - Wiley, Hoboken
T2  - Journal of Oral Pathology & Medicine
T1  - TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development
VL  - 46
IS  - 4
SP  - 292
EP  - 296
DO  - 10.1111/jop.12564
ER  - 
@article{
author = "Ilić, Branislav and Nikolić, Nadja and Andrić, Miroslav and Jelovac, Drago and Miličić, Biljana and Jozić, Tanja and Krstić, Slobodan and Milašin, Jelena",
year = "2017",
abstract = "BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P  lt  0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P  lt  0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Pathology & Medicine",
title = "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development",
volume = "46",
number = "4",
pages = "292-296",
doi = "10.1111/jop.12564"
}
Ilić, B., Nikolić, N., Andrić, M., Jelovac, D., Miličić, B., Jozić, T., Krstić, S.,& Milašin, J.. (2017). TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine
Wiley, Hoboken., 46(4), 292-296.
https://doi.org/10.1111/jop.12564
Ilić B, Nikolić N, Andrić M, Jelovac D, Miličić B, Jozić T, Krstić S, Milašin J. TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine. 2017;46(4):292-296.
doi:10.1111/jop.12564 .
Ilić, Branislav, Nikolić, Nadja, Andrić, Miroslav, Jelovac, Drago, Miličić, Biljana, Jozić, Tanja, Krstić, Slobodan, Milašin, Jelena, "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development" in Journal of Oral Pathology & Medicine, 46, no. 4 (2017):292-296,
https://doi.org/10.1111/jop.12564 . .
7
5
7

Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study

Brković, Božidar; Andrić, Miroslav; Ćalasan, Dejan; Milić, Marija; Stepić, Jelena; Vučetić, Milan; Brajković, Denis; Todorović, Ljubomir

(Springer Heidelberg, Heidelberg, 2017)

TY  - JOUR
AU  - Brković, Božidar
AU  - Andrić, Miroslav
AU  - Ćalasan, Dejan
AU  - Milić, Marija
AU  - Stepić, Jelena
AU  - Vučetić, Milan
AU  - Brajković, Denis
AU  - Todorović, Ljubomir
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2241
AB  - The purpose of this study was to investigate postoperative analgesic effect of ropivacaine administered as main or supplemental injection for the inferior alveolar nerve block (IANB) in patients undergoing lower third molar surgery. The double-blind randomized study comprised 72 healthy patients. All patients received two blocks, the IANB for surgical procedure + IANB after surgery for postoperative pain control, and were divided into three groups: (1) 2 % lidocaine/epinephrine + 1 % ropivacaine, (2) 2 % lidocaine/epinephrine + saline, and (3) 1 % ropivacaine + saline. The occurrence of postoperative pain, pain intensity and analgesic requirements were recorded. Data were statistically analyzed using chi-square, Fisher, and Kruskal-Wallis tests and analysis of variance (ANOVA) with Bonferroni and Tukey correction. Ropivacaine was more successful than lidocaine/epinephrine in obtaining duration of postoperative analgesia, reduction of pain, and analgesic requirements whether ropivacaine was used for surgical block or administered as a supplemental injection after surgery. Ropivacaine (1 %, 2 ml) resulted in effective postoperative analgesia after lower third molar surgery. Since pain control related to third molar surgery requires the effective surgical anesthesia and postoperative analgesia, the use of 1 % ropivacaine could be clinically relevant in a selection of appropriate pain control regimen for both surgical procedure and early postsurgical treatment.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study
VL  - 21
IS  - 3
SP  - 779
EP  - 785
DO  - 10.1007/s00784-016-1831-2
ER  - 
@article{
author = "Brković, Božidar and Andrić, Miroslav and Ćalasan, Dejan and Milić, Marija and Stepić, Jelena and Vučetić, Milan and Brajković, Denis and Todorović, Ljubomir",
year = "2017",
abstract = "The purpose of this study was to investigate postoperative analgesic effect of ropivacaine administered as main or supplemental injection for the inferior alveolar nerve block (IANB) in patients undergoing lower third molar surgery. The double-blind randomized study comprised 72 healthy patients. All patients received two blocks, the IANB for surgical procedure + IANB after surgery for postoperative pain control, and were divided into three groups: (1) 2 % lidocaine/epinephrine + 1 % ropivacaine, (2) 2 % lidocaine/epinephrine + saline, and (3) 1 % ropivacaine + saline. The occurrence of postoperative pain, pain intensity and analgesic requirements were recorded. Data were statistically analyzed using chi-square, Fisher, and Kruskal-Wallis tests and analysis of variance (ANOVA) with Bonferroni and Tukey correction. Ropivacaine was more successful than lidocaine/epinephrine in obtaining duration of postoperative analgesia, reduction of pain, and analgesic requirements whether ropivacaine was used for surgical block or administered as a supplemental injection after surgery. Ropivacaine (1 %, 2 ml) resulted in effective postoperative analgesia after lower third molar surgery. Since pain control related to third molar surgery requires the effective surgical anesthesia and postoperative analgesia, the use of 1 % ropivacaine could be clinically relevant in a selection of appropriate pain control regimen for both surgical procedure and early postsurgical treatment.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study",
volume = "21",
number = "3",
pages = "779-785",
doi = "10.1007/s00784-016-1831-2"
}
Brković, B., Andrić, M., Ćalasan, D., Milić, M., Stepić, J., Vučetić, M., Brajković, D.,& Todorović, L.. (2017). Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 21(3), 779-785.
https://doi.org/10.1007/s00784-016-1831-2
Brković B, Andrić M, Ćalasan D, Milić M, Stepić J, Vučetić M, Brajković D, Todorović L. Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study. in Clinical Oral Investigations. 2017;21(3):779-785.
doi:10.1007/s00784-016-1831-2 .
Brković, Božidar, Andrić, Miroslav, Ćalasan, Dejan, Milić, Marija, Stepić, Jelena, Vučetić, Milan, Brajković, Denis, Todorović, Ljubomir, "Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study" in Clinical Oral Investigations, 21, no. 3 (2017):779-785,
https://doi.org/10.1007/s00784-016-1831-2 . .
1
24
11
21

The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review

Jakovljević, Aleksandar; Kuzmanović, Jovana; Dragan, Irina E.; Knežević, Aleksandra; Miletić, Maja; Beljić-Ivanović, Katarina; Milašin, Jelena; Andrić, Miroslav

(Elsevier Science Inc, New York, 2017)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Kuzmanović, Jovana
AU  - Dragan, Irina E.
AU  - Knežević, Aleksandra
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2223
AB  - Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review
VL  - 43
IS  - 8
SP  - 1230
EP  - 1236
DO  - 10.1016/j.joen.2017.04.021
ER  - 
@article{
author = "Jakovljević, Aleksandar and Kuzmanović, Jovana and Dragan, Irina E. and Knežević, Aleksandra and Miletić, Maja and Beljić-Ivanović, Katarina and Milašin, Jelena and Andrić, Miroslav",
year = "2017",
abstract = "Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies. Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. A qualitative critical appraisal of the included articles was performed. Results: The electronic database search. yielded 66 hits from PubMed, 73 hits from Web of Science, and 107 from Scopus: Seven case reports and 3 cross-sectional studies were included in the final review. When summarized, in 7 patients with a history of a previous HZ attack and with no other apparent cause, -23 teeth were diagnosed with apical periodontitis, 8 teeth with internal and 1 tooth with external root resorption. The cross-sectional studies investigated the presence of VZV DNA in samples of acute apical abscess. The VZV DNA was found only in 2 of 65 samples. Conclusions: All studies included in this systematic review.had a low level of evidence (4 and 5). Still, the potential role of VZV in the etiopathogenesis of periapical pathoses and root resorption cannot be ruled out. Future investigations should be directed toward the analysis of VZV pathologic effects on pulp blood vessels, which might cause local ischemia and tissue necrosis.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review",
volume = "43",
number = "8",
pages = "1230-1236",
doi = "10.1016/j.joen.2017.04.021"
}
Jakovljević, A., Kuzmanović, J., Dragan, I. E., Knežević, A., Miletić, M., Beljić-Ivanović, K., Milašin, J.,& Andrić, M.. (2017). The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics
Elsevier Science Inc, New York., 43(8), 1230-1236.
https://doi.org/10.1016/j.joen.2017.04.021
Jakovljević A, Kuzmanović J, Dragan IE, Knežević A, Miletić M, Beljić-Ivanović K, Milašin J, Andrić M. The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. in Journal of Endodontics. 2017;43(8):1230-1236.
doi:10.1016/j.joen.2017.04.021 .
Jakovljević, Aleksandar, Kuzmanović, Jovana, Dragan, Irina E., Knežević, Aleksandra, Miletić, Maja, Beljić-Ivanović, Katarina, Milašin, Jelena, Andrić, Miroslav, "The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review" in Journal of Endodontics, 43, no. 8 (2017):1230-1236,
https://doi.org/10.1016/j.joen.2017.04.021 . .
6
1
6

Herpesviral-bacterial co-infection in mandibular third molar pericoronitis

Jakovljević, Aleksandar; Andrić, Miroslav; Knežević, Aleksandra; Miličić, Biljana; Beljić-Ivanović, Katarina; Perunović, Neda; Nikolić, Nadja; Milašin, Jelena

(Springer Heidelberg, Heidelberg, 2017)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Miličić, Biljana
AU  - Beljić-Ivanović, Katarina
AU  - Perunović, Neda
AU  - Nikolić, Nadja
AU  - Milašin, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2189
AB  - The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia. Pericoronitis samples harbored HCMV and EBV at significantly higher rates than the control group (70 vs. 40 % and 46.7 vs. 15 %, P = 0.035, P = 0.021, respectively). P. micra and T. forsythia (66.7 vs. 0 %, and 40 vs. 10 %, P = 0.001, P = 0.021, respectively) were significantly more common in pericoronitis compared to the control group. Multivariate logistic regression analysis showed that the presence of T. forsythia was associated with pericoronitis development (OR 7.3, 95 % CI, 1.2-43.2, P = 0.028). The occurrence of HCVM and EBV extends our previous knowledge on microbiota in pericoronitis. These PCR-based findings demonstrated that bacterial and viral DNA occurred concomitantly in pericoronitis samples. T. forsythia appeared to be significantly associated with pericoronitis development in the examined sample. Herpesviral-bacterial co-infections might exacerbate the progression of pericoronitis.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Herpesviral-bacterial co-infection in mandibular third molar pericoronitis
VL  - 21
IS  - 5
SP  - 1639
EP  - 1646
DO  - 10.1007/s00784-016-1955-4
ER  - 
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Miličić, Biljana and Beljić-Ivanović, Katarina and Perunović, Neda and Nikolić, Nadja and Milašin, Jelena",
year = "2017",
abstract = "The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia. Pericoronitis samples harbored HCMV and EBV at significantly higher rates than the control group (70 vs. 40 % and 46.7 vs. 15 %, P = 0.035, P = 0.021, respectively). P. micra and T. forsythia (66.7 vs. 0 %, and 40 vs. 10 %, P = 0.001, P = 0.021, respectively) were significantly more common in pericoronitis compared to the control group. Multivariate logistic regression analysis showed that the presence of T. forsythia was associated with pericoronitis development (OR 7.3, 95 % CI, 1.2-43.2, P = 0.028). The occurrence of HCVM and EBV extends our previous knowledge on microbiota in pericoronitis. These PCR-based findings demonstrated that bacterial and viral DNA occurred concomitantly in pericoronitis samples. T. forsythia appeared to be significantly associated with pericoronitis development in the examined sample. Herpesviral-bacterial co-infections might exacerbate the progression of pericoronitis.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Herpesviral-bacterial co-infection in mandibular third molar pericoronitis",
volume = "21",
number = "5",
pages = "1639-1646",
doi = "10.1007/s00784-016-1955-4"
}
Jakovljević, A., Andrić, M., Knežević, A., Miličić, B., Beljić-Ivanović, K., Perunović, N., Nikolić, N.,& Milašin, J.. (2017). Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 21(5), 1639-1646.
https://doi.org/10.1007/s00784-016-1955-4
Jakovljević A, Andrić M, Knežević A, Miličić B, Beljić-Ivanović K, Perunović N, Nikolić N, Milašin J. Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. in Clinical Oral Investigations. 2017;21(5):1639-1646.
doi:10.1007/s00784-016-1955-4 .
Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Miličić, Biljana, Beljić-Ivanović, Katarina, Perunović, Neda, Nikolić, Nadja, Milašin, Jelena, "Herpesviral-bacterial co-infection in mandibular third molar pericoronitis" in Clinical Oral Investigations, 21, no. 5 (2017):1639-1646,
https://doi.org/10.1007/s00784-016-1955-4 . .
4
13
9
13

Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes

Kosanić, Ivan; Andrić, Miroslav; Brković, Božidar; Koković, Vladimir; Jurišić, Milan

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2017)

TY  - JOUR
AU  - Kosanić, Ivan
AU  - Andrić, Miroslav
AU  - Brković, Božidar
AU  - Koković, Vladimir
AU  - Jurišić, Milan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2233
AB  - Background/Aim. The use of autogenous bone grafts for augmentation of the resorbed alveolar ridge is still considered the gold standard in implant dentistry. The aim of this study was to analyze the resorption rate of autogenous bone block grafts from the retromolar region placed in the frontal segment of the upper jaw unprotected by barrier membranes, to assess the stability of implants placed into the grafted bone, as well as to monitor its changes during the healing period. Methods. The study included 18 patients with a total of 20 grafted sites. The residual alveolar ridge was measured before and after the augmentation and prior to implant placement. All implants were restored with provisional crowns within 48 hours after the placement. Implant stability was assessed using resonance frequency analysis. Results. The average period from ridge augmentation to reentry was 5.4 months (range 4-6 months) . At reentry the healed alveolar ridge had a mean width of 6.1 ± 1.27 mm. The mean calculated width gain was 3.04 ± 1.22 mm. The overall surface resorption of block grafts was 0.68 ± 0.69 mm (18.85%). At the time of implant placement the mean value of implant stability quotient (ISQ) was 71.25 ± 5.77. The lowest ISQ values were noted after three weeks of healing, followed by a gradual increase until week 12. After 12 weeks implants showed significantly higher ISQ values compared to primary stability (p  lt  0.05 Wilcoxon signed ranks test). During the 3-years followup period no cases of implant loss were recorded. Conclusion. Despite a significant resorption of bone grafts, it was possible to place implants in all the cases and to use the immediate loading protocol without affecting implant survival rate.
AB  - Uvod/cilj. Primena autogenih koštanih graftova (implantata) za uvećavanje smanjenog (resorbovanog) alvelarnog grebena još uvek se smatra zlatnim standardom u implantologiji. Cilj ove studije bio je analiza stepena resorpcije autolognih koštanih blok transplantata nezaštićenih barijernim mebranama, uzetih iz retromolarnog predela mandibule i postavljenih u frontalni segment gornje vilice, procena stabilnosti implantata ugrađenih u povećanu regiju, kao i praćenje promene implantne stabilnosti tokom perioda oseointegracije. Metode. U studiju je bilo uključeno 18 pacijenata sa ukupno 20 autotransplantata. Širina rezidualnog alveolarnog grebena merena je pre i posle postavljanja transplantata, kao i neposredno pre ugradnje implantata. Svi implantati su opterećeni privremenim nadoknadama 48 sati nakon ugradnje. Stabilnost implantata procenjivana je primenom analize rezonantne frekvencije. Rezultati. Srednje vreme između uvećavanja grebena i ugradnje implantata iznosilo je 5,4 (4-6) meseci. Pre ugradnje implantata srednja vrednost širine grebena iznosila je 6,1 ± 1,27 mm, a povećanja širine grebena u odnosu na vrednosti pre uvećanja 3,04 ± 1,22 mm. Površinska resoprcija grafta iznosila je 18,85% (0,68 ± 0,69 mm). Srednja vrednost koeficijenta implantne stabilnosti (ISQ) u momentu ugradnje iznosila je 71,25 ± 5,77. Najniže vrednosti ISQ zabeležene su u trećoj nedelji nakon ugradnje, što je bilo praćeno postepenim porastom do dvanaeste nedelje zarastanja. Nakon dvanaest nedelja vrednosti ISQ bile su statitički značajno više od vrednosti u momentu ugradnje (p  lt  0,05 Wilcoxon test). Tokom trogodišnjeg perioda praćenja nije bilo izgubljenih implantata. Zaključak. Bez obzira na značajan stepen resorpcije autotransplantata, kod svih pacijenata bilo je moguće ugraditi implantate u uvećani greben, kao i primeniti protokol ranog opterećenja bez uticaja na stepen preživljavanja implantata.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes
T1  - Nezaštićeni koštani autotransplantati u prednjem segmentu gornje vilice - stepen resorpcije i klinički rezultati
VL  - 74
IS  - 4
SP  - 305
EP  - 310
DO  - 10.2298/VSP150429188K
ER  - 
@article{
author = "Kosanić, Ivan and Andrić, Miroslav and Brković, Božidar and Koković, Vladimir and Jurišić, Milan",
year = "2017",
abstract = "Background/Aim. The use of autogenous bone grafts for augmentation of the resorbed alveolar ridge is still considered the gold standard in implant dentistry. The aim of this study was to analyze the resorption rate of autogenous bone block grafts from the retromolar region placed in the frontal segment of the upper jaw unprotected by barrier membranes, to assess the stability of implants placed into the grafted bone, as well as to monitor its changes during the healing period. Methods. The study included 18 patients with a total of 20 grafted sites. The residual alveolar ridge was measured before and after the augmentation and prior to implant placement. All implants were restored with provisional crowns within 48 hours after the placement. Implant stability was assessed using resonance frequency analysis. Results. The average period from ridge augmentation to reentry was 5.4 months (range 4-6 months) . At reentry the healed alveolar ridge had a mean width of 6.1 ± 1.27 mm. The mean calculated width gain was 3.04 ± 1.22 mm. The overall surface resorption of block grafts was 0.68 ± 0.69 mm (18.85%). At the time of implant placement the mean value of implant stability quotient (ISQ) was 71.25 ± 5.77. The lowest ISQ values were noted after three weeks of healing, followed by a gradual increase until week 12. After 12 weeks implants showed significantly higher ISQ values compared to primary stability (p  lt  0.05 Wilcoxon signed ranks test). During the 3-years followup period no cases of implant loss were recorded. Conclusion. Despite a significant resorption of bone grafts, it was possible to place implants in all the cases and to use the immediate loading protocol without affecting implant survival rate., Uvod/cilj. Primena autogenih koštanih graftova (implantata) za uvećavanje smanjenog (resorbovanog) alvelarnog grebena još uvek se smatra zlatnim standardom u implantologiji. Cilj ove studije bio je analiza stepena resorpcije autolognih koštanih blok transplantata nezaštićenih barijernim mebranama, uzetih iz retromolarnog predela mandibule i postavljenih u frontalni segment gornje vilice, procena stabilnosti implantata ugrađenih u povećanu regiju, kao i praćenje promene implantne stabilnosti tokom perioda oseointegracije. Metode. U studiju je bilo uključeno 18 pacijenata sa ukupno 20 autotransplantata. Širina rezidualnog alveolarnog grebena merena je pre i posle postavljanja transplantata, kao i neposredno pre ugradnje implantata. Svi implantati su opterećeni privremenim nadoknadama 48 sati nakon ugradnje. Stabilnost implantata procenjivana je primenom analize rezonantne frekvencije. Rezultati. Srednje vreme između uvećavanja grebena i ugradnje implantata iznosilo je 5,4 (4-6) meseci. Pre ugradnje implantata srednja vrednost širine grebena iznosila je 6,1 ± 1,27 mm, a povećanja širine grebena u odnosu na vrednosti pre uvećanja 3,04 ± 1,22 mm. Površinska resoprcija grafta iznosila je 18,85% (0,68 ± 0,69 mm). Srednja vrednost koeficijenta implantne stabilnosti (ISQ) u momentu ugradnje iznosila je 71,25 ± 5,77. Najniže vrednosti ISQ zabeležene su u trećoj nedelji nakon ugradnje, što je bilo praćeno postepenim porastom do dvanaeste nedelje zarastanja. Nakon dvanaest nedelja vrednosti ISQ bile su statitički značajno više od vrednosti u momentu ugradnje (p  lt  0,05 Wilcoxon test). Tokom trogodišnjeg perioda praćenja nije bilo izgubljenih implantata. Zaključak. Bez obzira na značajan stepen resorpcije autotransplantata, kod svih pacijenata bilo je moguće ugraditi implantate u uvećani greben, kao i primeniti protokol ranog opterećenja bez uticaja na stepen preživljavanja implantata.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes, Nezaštićeni koštani autotransplantati u prednjem segmentu gornje vilice - stepen resorpcije i klinički rezultati",
volume = "74",
number = "4",
pages = "305-310",
doi = "10.2298/VSP150429188K"
}
Kosanić, I., Andrić, M., Brković, B., Koković, V.,& Jurišić, M.. (2017). Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(4), 305-310.
https://doi.org/10.2298/VSP150429188K
Kosanić I, Andrić M, Brković B, Koković V, Jurišić M. Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes. in Vojnosanitetski pregled. 2017;74(4):305-310.
doi:10.2298/VSP150429188K .
Kosanić, Ivan, Andrić, Miroslav, Brković, Božidar, Koković, Vladimir, Jurišić, Milan, "Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes" in Vojnosanitetski pregled, 74, no. 4 (2017):305-310,
https://doi.org/10.2298/VSP150429188K . .
1

Herpesviruses in Periapical Pathoses: An Updated Systematic Review

Ongrádi, Joseph; Jakovljević, Aleksandar; Andrić, Miroslav; Knežević, Aleksandra; Beljić-Ivanović, Katarina; Miletić, Maja; Jovanović, Tanja; Kesić, Ljiljana; Milasin, Jelena

(Rijeka : InTech, 2016)

TY  - CHAP
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Beljić-Ivanović, Katarina
AU  - Miletić, Maja
AU  - Jovanović, Tanja
AU  - Kesić, Ljiljana
AU  - Milasin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2597
AB  - Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.
PB  - Rijeka : InTech
T2  - Herpesviridae
T1  - Herpesviruses in Periapical Pathoses: An Updated Systematic Review
SP  - 31
EP  - 74
DO  - 10.5772/64004
ER  - 
@inbook{
editor = "Ongrádi, Joseph",
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Beljić-Ivanović, Katarina and Miletić, Maja and Jovanović, Tanja and Kesić, Ljiljana and Milasin, Jelena",
year = "2016",
abstract = "Apical periodontitis represents a chronic inflammation and destruction of periradicular tissue caused by polymicrobial infection of endodontic origin. The aim of this systematic review was to make an update on findings related to Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) presence in periapical pathoses and to correlate these findings with clinical, histopathological and radiographic features of periapical lesions. Methods were based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. A search was performed using PubMed, Web of Science and SCOPUS. Search key words included the following medical subjects heading terms: (periapical disease OR apical periodontitis OR periapical lesions OR periapical abscess) AND (viruses OR herpesvir*). A manual search involved references from articles retrieved for possible inclusion. The search, evalua‐ tion, and critical appraisal of articles were performed by two independent judges. Collected data were analyzed using the measures of descriptive statistics. The final review has included twenty nine articles related to herpesviral presence periapical pathoses. Qualitative analysis indicated that EBV HCMV, and HHV-8 were the most prevalent species in periapical pathoses. Our findings suggest that there is wide variety of herpesviruses detection rates in periapical pathoses in relation to their clinical, histopathological and radiographic features.",
publisher = "Rijeka : InTech",
journal = "Herpesviridae",
booktitle = "Herpesviruses in Periapical Pathoses: An Updated Systematic Review",
pages = "31-74",
doi = "10.5772/64004"
}
Ongrádi, J., Jakovljević, A., Andrić, M., Knežević, A., Beljić-Ivanović, K., Miletić, M., Jovanović, T., Kesić, L.,& Milasin, J.. (2016). Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae
Rijeka : InTech., 31-74.
https://doi.org/10.5772/64004
Ongrádi J, Jakovljević A, Andrić M, Knežević A, Beljić-Ivanović K, Miletić M, Jovanović T, Kesić L, Milasin J. Herpesviruses in Periapical Pathoses: An Updated Systematic Review. in Herpesviridae. 2016;:31-74.
doi:10.5772/64004 .
Ongrádi, Joseph, Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Beljić-Ivanović, Katarina, Miletić, Maja, Jovanović, Tanja, Kesić, Ljiljana, Milasin, Jelena, "Herpesviruses in Periapical Pathoses: An Updated Systematic Review" in Herpesviridae (2016):31-74,
https://doi.org/10.5772/64004 . .
5

Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species

Jakovljević, Aleksandar; Andrić, Miroslav; Miletić, Maja; Beljić-Ivanović, Katarina; Knežević, Aleksandra; Mojsilović, Slavko; Milašin, Jelena

(Churchill Livingstone, Edinburgh, 2016)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Miletić, Maja
AU  - Beljić-Ivanović, Katarina
AU  - Knežević, Aleksandra
AU  - Mojsilović, Slavko
AU  - Milašin, Jelena
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2147
AB  - Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species
VL  - 94
SP  - 40
EP  - 42
DO  - 10.1016/j.mehy.2016.06.020
ER  - 
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Miletić, Maja and Beljić-Ivanović, Katarina and Knežević, Aleksandra and Mojsilović, Slavko and Milašin, Jelena",
year = "2016",
abstract = "Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated. We hypothesize that EBV infection in apical periodontitis is capable of inducing periapical bone resorption via stimulation of reactive oxygen species (ROS) overproduction. Increased levels of ROS induce expression of receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL). RANKL binding to receptor activator of nuclear factor kappa B (RANK) present on the surface of preosteoclasts induces their maturation and activation which consequently leads to bone resorption. The potential benefit of antiviral and antioxidant-based therapies in periapical bone resorption treatment remains to be assessed.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species",
volume = "94",
pages = "40-42",
doi = "10.1016/j.mehy.2016.06.020"
}
Jakovljević, A., Andrić, M., Miletić, M., Beljić-Ivanović, K., Knežević, A., Mojsilović, S.,& Milašin, J.. (2016). Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 94, 40-42.
https://doi.org/10.1016/j.mehy.2016.06.020
Jakovljević A, Andrić M, Miletić M, Beljić-Ivanović K, Knežević A, Mojsilović S, Milašin J. Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species. in Medical Hypotheses. 2016;94:40-42.
doi:10.1016/j.mehy.2016.06.020 .
Jakovljević, Aleksandar, Andrić, Miroslav, Miletić, Maja, Beljić-Ivanović, Katarina, Knežević, Aleksandra, Mojsilović, Slavko, Milašin, Jelena, "Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species" in Medical Hypotheses, 94 (2016):40-42,
https://doi.org/10.1016/j.mehy.2016.06.020 . .
24
12
20

Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression

Brajić, Ivana; Skodrić, Sanja; Milenković, S.; Tepavčević, Zvezdana; Soldatović, Ivan; Čolić, Snježana; Milašin, Jelena; Andrić, Miroslav

(Wiley-Blackwell, Hoboken, 2016)

TY  - JOUR
AU  - Brajić, Ivana
AU  - Skodrić, Sanja
AU  - Milenković, S.
AU  - Tepavčević, Zvezdana
AU  - Soldatović, Ivan
AU  - Čolić, Snježana
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2140
AB  - ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.
PB  - Wiley-Blackwell, Hoboken
T2  - Oral Diseases
T1  - Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression
VL  - 22
IS  - 3
SP  - 220
EP  - 225
DO  - 10.1111/odi.12414
ER  - 
@article{
author = "Brajić, Ivana and Skodrić, Sanja and Milenković, S. and Tepavčević, Zvezdana and Soldatović, Ivan and Čolić, Snježana and Milašin, Jelena and Andrić, Miroslav",
year = "2016",
abstract = "ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Oral Diseases",
title = "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression",
volume = "22",
number = "3",
pages = "220-225",
doi = "10.1111/odi.12414"
}
Brajić, I., Skodrić, S., Milenković, S., Tepavčević, Z., Soldatović, I., Čolić, S., Milašin, J.,& Andrić, M.. (2016). Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases
Wiley-Blackwell, Hoboken., 22(3), 220-225.
https://doi.org/10.1111/odi.12414
Brajić I, Skodrić S, Milenković S, Tepavčević Z, Soldatović I, Čolić S, Milašin J, Andrić M. Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases. 2016;22(3):220-225.
doi:10.1111/odi.12414 .
Brajić, Ivana, Skodrić, Sanja, Milenković, S., Tepavčević, Zvezdana, Soldatović, Ivan, Čolić, Snježana, Milašin, Jelena, Andrić, Miroslav, "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression" in Oral Diseases, 22, no. 3 (2016):220-225,
https://doi.org/10.1111/odi.12414 . .
3
1
1

Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study

Todorović, Vladimir S.; Vasović, Miroslav; Andrić, Miroslav; Todorović, Ljubomir; Koković, Vladimir

(Medicina Oral S L, Valencia, 2016)

TY  - JOUR
AU  - Todorović, Vladimir S.
AU  - Vasović, Miroslav
AU  - Andrić, Miroslav
AU  - Todorović, Ljubomir
AU  - Koković, Vladimir
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2121
AB  - Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.
PB  - Medicina Oral S L, Valencia
T2  - Medicina Oral Patologia Oral Y Cirugia Bucal
T1  - Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study
VL  - 21
IS  - 5
SP  - E621
EP  - E625
DO  - 10.4317/medoral.21161
ER  - 
@article{
author = "Todorović, Vladimir S. and Vasović, Miroslav and Andrić, Miroslav and Todorović, Ljubomir and Koković, Vladimir",
year = "2016",
abstract = "Background: Surgical removal of impacted lower third molars is a common oral surgical procedure, generally followed by moderate to severe postoperative pain. Transdermal drug delivery as a concept offers interesting possibilities for postoperative pain control. The aim of this study was to evaluate the efficacy of transdermal system with fentanyl in relieving pain following impacted lower third molar surgery. Material and Methods: Seventeen patients with bilateral impacted lower third molars were included in this preliminary study. For postoperative pain control, patients randomly received a fentanyl patch plus placebo tablet after the first operation and regular (placebo) patch and an analgesic, after the second operation. Analgesia was evaluated during first 24 hours postoperatively according to patients' reports about time of first pain appearance and additional analgesic consumption. Pain severity was rated using a 10 cm long visual analogue scale (VAS). Results: Intensity of postoperative pain and postoperative analgesic consumption were significantly lower after the Fentanyl Transdermal System (FTS) was applied (p lt 0.05). Duration of postoperative analgesia was significantly higher with FTS when compared to control treatment (p lt 0.05). Conclusions: Based on the results of this preliminary study, transdermal system with fentanyl significantly reduced postoperative pain after third molar surgery.",
publisher = "Medicina Oral S L, Valencia",
journal = "Medicina Oral Patologia Oral Y Cirugia Bucal",
title = "Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study",
volume = "21",
number = "5",
pages = "E621-E625",
doi = "10.4317/medoral.21161"
}
Todorović, V. S., Vasović, M., Andrić, M., Todorović, L.,& Koković, V.. (2016). Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. in Medicina Oral Patologia Oral Y Cirugia Bucal
Medicina Oral S L, Valencia., 21(5), E621-E625.
https://doi.org/10.4317/medoral.21161
Todorović VS, Vasović M, Andrić M, Todorović L, Koković V. Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study. in Medicina Oral Patologia Oral Y Cirugia Bucal. 2016;21(5):E621-E625.
doi:10.4317/medoral.21161 .
Todorović, Vladimir S., Vasović, Miroslav, Andrić, Miroslav, Todorović, Ljubomir, Koković, Vladimir, "Efficacy of fentanyl transdermal patch in pain control after lower third molar surgery: A preliminary study" in Medicina Oral Patologia Oral Y Cirugia Bucal, 21, no. 5 (2016):E621-E625,
https://doi.org/10.4317/medoral.21161 . .
1
11
2
9

Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits

Živadinović, Milka; Andrić, Miroslav; Milošević, Verica; Manojlović-Stojanoski, Milica; Prokić, Branislav; Prokić, Bogomir; Dimić, Aleksandar; Ćalasan, Dejan; Brković, Božidar

(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 2016)

TY  - JOUR
AU  - Živadinović, Milka
AU  - Andrić, Miroslav
AU  - Milošević, Verica
AU  - Manojlović-Stojanoski, Milica
AU  - Prokić, Branislav
AU  - Prokić, Bogomir
AU  - Dimić, Aleksandar
AU  - Ćalasan, Dejan
AU  - Brković, Božidar
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2082
AB  - Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as unfilled controls (n = 4). After 4 weeks of healing, animals were sacrificed and calvarial bone blocks were taken for histologic and histomorphometric analysis. Beside descriptive histologic evaluation, the percentage of new bone formation, connective tissue and residual graft were calculated. All parameters were statistically evaluated by Friedman Test and post hock Wilcoxon Singed Ranks Test with a significance of p  lt  0.05. Results. Histology revealed active new bone formation peripherally with centrally located connective tissue, newly formed woven bone and well incorporated residual grafts in all treated defects. Control samples showed no bone bridging of defects. There was a significantly more new bone in autogeonous graft (53%) compared with β-tricalcium phosphate (30%), (p  lt  0.030) and control (7%), (p  lt  0.000) groups. A significant difference was also recorded between β-tricalcium phosphate and control groups (p  lt  0.008). Conclusion. In the present study on the rabbit grafting model with induced diabetes mellitus type I, the effective bone regeneration of critical bone defects was obtained using autogenous bone graft.
AB  - Uvod/Cilj. Mehanizam otežanog zarastanja tkiva kod dijabetesa melitusa zasnovan je na različitim promenama funkcije na tkivnom i ćelijskom nivou, usled prisutnih mikro- i makrovaskularnih promena. Kao hronično metaboličko oboljenje sa vaskularnim komplikacijama, dijabetes melitus zahvata i proces koštane regeneracije. Terapijski postupci u okviru regeneracije kosti obuhvataju primenu autotransplantata sa oseoinduktivnim delovanjem i sintetskih osteokonduktivnih materijala, kao što je i β-trikalcijum fosfat. Cilj ovog rada bio je da se ispita kvantitet i kvalitet novoformiranog koštanog tkiva posle korišćenja autotransplantata kosti i β-trikalcijum fosfata, na modelu kritičnog defekta kalvarije kunića sa eksperimentalno izazvanim dijabetesom melitusom tipa I. Metode. U ovo istraživanje bilo je uključeno 8 kunića (soj Činičila), starosti 4 meseca, kod kojih je dijabetes melitus tipa I bio izazvan aloksanom. Kod svih životinja hirurški je urađen defekt kritičneveličine na kosti kalvarije (prečnika 12 mm), koji je popunjen autotransplantatom kosti i β-trikalcijum fosfatom (n = 4) ili je ostavljen da spontano zarasta kao kontrolni defekt (n = 4). Posle 4 nedelje, sve životinje su bile žrtvovane i koštani uzorci uzeti za histološku i histomorfometrijsku analizu. Pored deskriptivne histološke analize, urađena je i kvantitativna analiza novoformirane kosti, vezivnog tkiva i materijala za koštanu regeneraciju. Statistička analiza vršena je primenom Friedmanovog testa i post hock Vilkoksonovog neparametrijskog testa sa stepenom značajnosti od p  lt  0,05. Rezultati. Histološka analiza uzoraka kosti pokazala je prisustvo novoformirane kosti na periferiji defekta, dok je u centralom delu bilo prisutno vezivno tkivo, nezrelo koštano tkivo i dobro sjedinjeni neresorbovani materijal za regeneraciju kosti. Kontrolni uzorci nisu pokazali koštano zarastanje defekata. Značajno više novoformirane kosti bilo je prisutno u defektima regenerisanim autotransplantatom (53%) u poređenju sa kontrolnim defektima (7%), (p  lt  0,000) i defektima popunjenim β-trikalcijum fosfatom (30%), (p  lt  0,030). Takođe, značajna razlika uočena je i između grupe sa β-trikalcijum fosfatom i kontrolnim koštanim defektom (p  lt  0,008). Zaključak. Primena autotransplantata kosti značajno povećava uspešnost regeneracije kritičnih defekata kosti kalvarije kunića sa dijabetesom melitusom tipa I.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits
T1  - Histomorfometrijska analiza regeneracije kosti kod kunića sa dijabetesom melitusom posle primene autotransplantata kosti i beta-trikalcijum fosfata
VL  - 73
IS  - 12
SP  - 1132
EP  - 1138
DO  - 10.2298/VSP151125013Z
ER  - 
@article{
author = "Živadinović, Milka and Andrić, Miroslav and Milošević, Verica and Manojlović-Stojanoski, Milica and Prokić, Branislav and Prokić, Bogomir and Dimić, Aleksandar and Ćalasan, Dejan and Brković, Božidar",
year = "2016",
abstract = "Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as unfilled controls (n = 4). After 4 weeks of healing, animals were sacrificed and calvarial bone blocks were taken for histologic and histomorphometric analysis. Beside descriptive histologic evaluation, the percentage of new bone formation, connective tissue and residual graft were calculated. All parameters were statistically evaluated by Friedman Test and post hock Wilcoxon Singed Ranks Test with a significance of p  lt  0.05. Results. Histology revealed active new bone formation peripherally with centrally located connective tissue, newly formed woven bone and well incorporated residual grafts in all treated defects. Control samples showed no bone bridging of defects. There was a significantly more new bone in autogeonous graft (53%) compared with β-tricalcium phosphate (30%), (p  lt  0.030) and control (7%), (p  lt  0.000) groups. A significant difference was also recorded between β-tricalcium phosphate and control groups (p  lt  0.008). Conclusion. In the present study on the rabbit grafting model with induced diabetes mellitus type I, the effective bone regeneration of critical bone defects was obtained using autogenous bone graft., Uvod/Cilj. Mehanizam otežanog zarastanja tkiva kod dijabetesa melitusa zasnovan je na različitim promenama funkcije na tkivnom i ćelijskom nivou, usled prisutnih mikro- i makrovaskularnih promena. Kao hronično metaboličko oboljenje sa vaskularnim komplikacijama, dijabetes melitus zahvata i proces koštane regeneracije. Terapijski postupci u okviru regeneracije kosti obuhvataju primenu autotransplantata sa oseoinduktivnim delovanjem i sintetskih osteokonduktivnih materijala, kao što je i β-trikalcijum fosfat. Cilj ovog rada bio je da se ispita kvantitet i kvalitet novoformiranog koštanog tkiva posle korišćenja autotransplantata kosti i β-trikalcijum fosfata, na modelu kritičnog defekta kalvarije kunića sa eksperimentalno izazvanim dijabetesom melitusom tipa I. Metode. U ovo istraživanje bilo je uključeno 8 kunića (soj Činičila), starosti 4 meseca, kod kojih je dijabetes melitus tipa I bio izazvan aloksanom. Kod svih životinja hirurški je urađen defekt kritičneveličine na kosti kalvarije (prečnika 12 mm), koji je popunjen autotransplantatom kosti i β-trikalcijum fosfatom (n = 4) ili je ostavljen da spontano zarasta kao kontrolni defekt (n = 4). Posle 4 nedelje, sve životinje su bile žrtvovane i koštani uzorci uzeti za histološku i histomorfometrijsku analizu. Pored deskriptivne histološke analize, urađena je i kvantitativna analiza novoformirane kosti, vezivnog tkiva i materijala za koštanu regeneraciju. Statistička analiza vršena je primenom Friedmanovog testa i post hock Vilkoksonovog neparametrijskog testa sa stepenom značajnosti od p  lt  0,05. Rezultati. Histološka analiza uzoraka kosti pokazala je prisustvo novoformirane kosti na periferiji defekta, dok je u centralom delu bilo prisutno vezivno tkivo, nezrelo koštano tkivo i dobro sjedinjeni neresorbovani materijal za regeneraciju kosti. Kontrolni uzorci nisu pokazali koštano zarastanje defekata. Značajno više novoformirane kosti bilo je prisutno u defektima regenerisanim autotransplantatom (53%) u poređenju sa kontrolnim defektima (7%), (p  lt  0,000) i defektima popunjenim β-trikalcijum fosfatom (30%), (p  lt  0,030). Takođe, značajna razlika uočena je i između grupe sa β-trikalcijum fosfatom i kontrolnim koštanim defektom (p  lt  0,008). Zaključak. Primena autotransplantata kosti značajno povećava uspešnost regeneracije kritičnih defekata kosti kalvarije kunića sa dijabetesom melitusom tipa I.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits, Histomorfometrijska analiza regeneracije kosti kod kunića sa dijabetesom melitusom posle primene autotransplantata kosti i beta-trikalcijum fosfata",
volume = "73",
number = "12",
pages = "1132-1138",
doi = "10.2298/VSP151125013Z"
}
Živadinović, M., Andrić, M., Milošević, V., Manojlović-Stojanoski, M., Prokić, B., Prokić, B., Dimić, A., Ćalasan, D.,& Brković, B.. (2016). Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(12), 1132-1138.
https://doi.org/10.2298/VSP151125013Z
Živadinović M, Andrić M, Milošević V, Manojlović-Stojanoski M, Prokić B, Prokić B, Dimić A, Ćalasan D, Brković B. Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits. in Vojnosanitetski pregled. 2016;73(12):1132-1138.
doi:10.2298/VSP151125013Z .
Živadinović, Milka, Andrić, Miroslav, Milošević, Verica, Manojlović-Stojanoski, Milica, Prokić, Branislav, Prokić, Bogomir, Dimić, Aleksandar, Ćalasan, Dejan, Brković, Božidar, "Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits" in Vojnosanitetski pregled, 73, no. 12 (2016):1132-1138,
https://doi.org/10.2298/VSP151125013Z . .
5
4
6

Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups

Jakovljević, Aleksandar; Lazić, Emira; Soldatović, Ivan; Nedeljković, Nenad; Andrić, Miroslav

(E H Angle Education Research Foundation, Inc, Newton N, 2015)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Lazić, Emira
AU  - Soldatović, Ivan
AU  - Nedeljković, Nenad
AU  - Andrić, Miroslav
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1967
AB  - Objective: To analyze radiographic predictors for lower third molar eruption among subjects with different anteroposterior skeletal relations and of different age groups. Materials and Methods: In total, 300 lower third molars were recorded on diagnostic digital orthopantomograms (DPTs) and lateral cephalograms (LCs). The radiographs were grouped according to sagittal intermaxillary angle (ANB), subject age, and level of lower third molar eruption. The DPT was used to analyze retromolar space, mesiodistal crown width, space/width ratio, third and second molar angulation (alpha, gamma), third molar inclination (beta), and gonion angle. The LC was used to determine ANB, angles of maxillar and mandibular prognathism (SNA, SNB), mandibular plane angle (SN/MP), and mandibular lengths. A logistic regression model was created using the statistically significant predictors. Results: The logistic regression analysis revealed a statistically significant impact of 6 angle and distance between gonion and gnathion (Go-On) on the level of lower third molar eruption (P  lt  .001 and P  lt  .015, respectively). The retromolar space was significantly increased in the adult subgroup for all skeletal classes. The lower third molar impaction rate was significantly higher in the adult subgroup with the Class II (62.3%) compared with Class III subjects (31.7%; P  lt  .013). Conclusion: The most favorable values of linear and angular predictors of mandibular third molar eruption were measured in Class III subjects. For valid estimation of mandibular third molar eruption, certain linear and angular measures (beta angle, Go-On), as well as the size of the retromolar space, need to be considered.
PB  - E H Angle Education Research Foundation, Inc, Newton N
T2  - Angle Orthodontist
T1  - Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups
VL  - 85
IS  - 4
SP  - 577
EP  - 584
DO  - 10.2319/062714-463.1
ER  - 
@article{
author = "Jakovljević, Aleksandar and Lazić, Emira and Soldatović, Ivan and Nedeljković, Nenad and Andrić, Miroslav",
year = "2015",
abstract = "Objective: To analyze radiographic predictors for lower third molar eruption among subjects with different anteroposterior skeletal relations and of different age groups. Materials and Methods: In total, 300 lower third molars were recorded on diagnostic digital orthopantomograms (DPTs) and lateral cephalograms (LCs). The radiographs were grouped according to sagittal intermaxillary angle (ANB), subject age, and level of lower third molar eruption. The DPT was used to analyze retromolar space, mesiodistal crown width, space/width ratio, third and second molar angulation (alpha, gamma), third molar inclination (beta), and gonion angle. The LC was used to determine ANB, angles of maxillar and mandibular prognathism (SNA, SNB), mandibular plane angle (SN/MP), and mandibular lengths. A logistic regression model was created using the statistically significant predictors. Results: The logistic regression analysis revealed a statistically significant impact of 6 angle and distance between gonion and gnathion (Go-On) on the level of lower third molar eruption (P  lt  .001 and P  lt  .015, respectively). The retromolar space was significantly increased in the adult subgroup for all skeletal classes. The lower third molar impaction rate was significantly higher in the adult subgroup with the Class II (62.3%) compared with Class III subjects (31.7%; P  lt  .013). Conclusion: The most favorable values of linear and angular predictors of mandibular third molar eruption were measured in Class III subjects. For valid estimation of mandibular third molar eruption, certain linear and angular measures (beta angle, Go-On), as well as the size of the retromolar space, need to be considered.",
publisher = "E H Angle Education Research Foundation, Inc, Newton N",
journal = "Angle Orthodontist",
title = "Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups",
volume = "85",
number = "4",
pages = "577-584",
doi = "10.2319/062714-463.1"
}
Jakovljević, A., Lazić, E., Soldatović, I., Nedeljković, N.,& Andrić, M.. (2015). Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups. in Angle Orthodontist
E H Angle Education Research Foundation, Inc, Newton N., 85(4), 577-584.
https://doi.org/10.2319/062714-463.1
Jakovljević A, Lazić E, Soldatović I, Nedeljković N, Andrić M. Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups. in Angle Orthodontist. 2015;85(4):577-584.
doi:10.2319/062714-463.1 .
Jakovljević, Aleksandar, Lazić, Emira, Soldatović, Ivan, Nedeljković, Nenad, Andrić, Miroslav, "Radiographic assessment of lower third molar eruption in different anteroposterior skeletal patterns and age-related groups" in Angle Orthodontist, 85, no. 4 (2015):577-584,
https://doi.org/10.2319/062714-463.1 . .
1
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11

Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions

Jakovljević, Aleksandar; Andrić, Miroslav; Knežević, Aleksandra; Soldatović, Ivan; Nikolić, Nadja; Karalić, Danijela; Milašin, Jelena

(Elsevier Science Inc, New York, 2015)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Andrić, Miroslav
AU  - Knežević, Aleksandra
AU  - Soldatović, Ivan
AU  - Nikolić, Nadja
AU  - Karalić, Danijela
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1996
AB  - Introduction: Different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) possess specific pathogenic abilities because of various interactions with the host's immune system and differences in cell tropism. The aim of this study was to determine the distribution of HCMV and EBV genotypes in apical periodontitis lesions in relation to their clinical and histopathologic features. Methods: One hundred samples of apical periodontitis lesions and 25 control samples (healthy pulp tissue) were collected. The presence of HCMV glycoprotein B (gB) and EBV nuclear antigen-2 genotypes was analyzed by nested polymerase chain reaction and restriction fragment length polymorphisms analysis. Results: EBV and HCMV were detected in apical periodontitis lesions at significantly higher frequencies than in healthy pulp controls (P = .020 and P = .020, respectively). HCMV gB type II was significantly more frequent compared with gB type I in the examined groups (P = .036). No HCMV gB type III or IV products were found. In both periapical lesions and controls, EBV-1 occurred more often compared with EBV-2 (P = .001). Dual EBV and HCMV coinfection was more frequently detected in large-size periapical lesions (P = .038). Conclusions: Both HCMV and EBV are associated with inflammatory processes of periapical bone destruction. HCMV gB type II and EBV-1 are the most prevalent genotypes in apical periodontitis lesions.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions
VL  - 41
IS  - 11
SP  - 1847
EP  - 1851
DO  - 10.1016/j.joen.2015.08.027
ER  - 
@article{
author = "Jakovljević, Aleksandar and Andrić, Miroslav and Knežević, Aleksandra and Soldatović, Ivan and Nikolić, Nadja and Karalić, Danijela and Milašin, Jelena",
year = "2015",
abstract = "Introduction: Different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) possess specific pathogenic abilities because of various interactions with the host's immune system and differences in cell tropism. The aim of this study was to determine the distribution of HCMV and EBV genotypes in apical periodontitis lesions in relation to their clinical and histopathologic features. Methods: One hundred samples of apical periodontitis lesions and 25 control samples (healthy pulp tissue) were collected. The presence of HCMV glycoprotein B (gB) and EBV nuclear antigen-2 genotypes was analyzed by nested polymerase chain reaction and restriction fragment length polymorphisms analysis. Results: EBV and HCMV were detected in apical periodontitis lesions at significantly higher frequencies than in healthy pulp controls (P = .020 and P = .020, respectively). HCMV gB type II was significantly more frequent compared with gB type I in the examined groups (P = .036). No HCMV gB type III or IV products were found. In both periapical lesions and controls, EBV-1 occurred more often compared with EBV-2 (P = .001). Dual EBV and HCMV coinfection was more frequently detected in large-size periapical lesions (P = .038). Conclusions: Both HCMV and EBV are associated with inflammatory processes of periapical bone destruction. HCMV gB type II and EBV-1 are the most prevalent genotypes in apical periodontitis lesions.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions",
volume = "41",
number = "11",
pages = "1847-1851",
doi = "10.1016/j.joen.2015.08.027"
}
Jakovljević, A., Andrić, M., Knežević, A., Soldatović, I., Nikolić, N., Karalić, D.,& Milašin, J.. (2015). Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions. in Journal of Endodontics
Elsevier Science Inc, New York., 41(11), 1847-1851.
https://doi.org/10.1016/j.joen.2015.08.027
Jakovljević A, Andrić M, Knežević A, Soldatović I, Nikolić N, Karalić D, Milašin J. Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions. in Journal of Endodontics. 2015;41(11):1847-1851.
doi:10.1016/j.joen.2015.08.027 .
Jakovljević, Aleksandar, Andrić, Miroslav, Knežević, Aleksandra, Soldatović, Ivan, Nikolić, Nadja, Karalić, Danijela, Milašin, Jelena, "Human Cytomegalovirus and Epstein-Barr Virus Genotypes in Apical Periodontitis Lesions" in Journal of Endodontics, 41, no. 11 (2015):1847-1851,
https://doi.org/10.1016/j.joen.2015.08.027 . .
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Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings

Jakovljević, Aleksandar; Knežević, Aleksandra; Karalić, Danijela; Soldatović, Ivan; Popović, Branka; Milašin, Jelena; Andrić, Miroslav

(Wiley, Hoboken, 2015)

TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Knežević, Aleksandra
AU  - Karalić, Danijela
AU  - Soldatović, Ivan
AU  - Popović, Branka
AU  - Milašin, Jelena
AU  - Andrić, Miroslav
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1986
AB  - This study aimed to compare the levels of tumour necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1) and interleukin-6 (IL-6) between apical periodontitis lesions with different clinical and histological features. Based on clinical data and history of disease, 100 human apical periodontitis lesions were categorised as either asymptomatic or symptomatic lesions. According to histological examination, lesions were divided into periapical granulomas and radicular cysts. Pulp tissues of 25 impacted wisdom teeth were used as controls. Homogenised tissue samples were centrifuged and supernatants were used for the determination of cytokine levels by enzyme-linked immunosorbent assay. Significantly higher levels of IL-1 and IL-6 were found in symptomatic lesions compared with asymptomatic lesions and control tissues (P lt 0.001, P lt 0.001, respectively). The concentration of IL-1 was significantly higher in radicular cysts compared with periapical granulomas (P=0.003). Symptomatic lesions, as judged by high local production of IL-1 and IL-6, represent an immunologically active stage of the disease.
PB  - Wiley, Hoboken
T2  - Australian Endodontic Journal
T1  - Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings
VL  - 41
IS  - 2
SP  - 72
EP  - 77
DO  - 10.1111/aej.12072
ER  - 
@article{
author = "Jakovljević, Aleksandar and Knežević, Aleksandra and Karalić, Danijela and Soldatović, Ivan and Popović, Branka and Milašin, Jelena and Andrić, Miroslav",
year = "2015",
abstract = "This study aimed to compare the levels of tumour necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1) and interleukin-6 (IL-6) between apical periodontitis lesions with different clinical and histological features. Based on clinical data and history of disease, 100 human apical periodontitis lesions were categorised as either asymptomatic or symptomatic lesions. According to histological examination, lesions were divided into periapical granulomas and radicular cysts. Pulp tissues of 25 impacted wisdom teeth were used as controls. Homogenised tissue samples were centrifuged and supernatants were used for the determination of cytokine levels by enzyme-linked immunosorbent assay. Significantly higher levels of IL-1 and IL-6 were found in symptomatic lesions compared with asymptomatic lesions and control tissues (P lt 0.001, P lt 0.001, respectively). The concentration of IL-1 was significantly higher in radicular cysts compared with periapical granulomas (P=0.003). Symptomatic lesions, as judged by high local production of IL-1 and IL-6, represent an immunologically active stage of the disease.",
publisher = "Wiley, Hoboken",
journal = "Australian Endodontic Journal",
title = "Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings",
volume = "41",
number = "2",
pages = "72-77",
doi = "10.1111/aej.12072"
}
Jakovljević, A., Knežević, A., Karalić, D., Soldatović, I., Popović, B., Milašin, J.,& Andrić, M.. (2015). Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings. in Australian Endodontic Journal
Wiley, Hoboken., 41(2), 72-77.
https://doi.org/10.1111/aej.12072
Jakovljević A, Knežević A, Karalić D, Soldatović I, Popović B, Milašin J, Andrić M. Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings. in Australian Endodontic Journal. 2015;41(2):72-77.
doi:10.1111/aej.12072 .
Jakovljević, Aleksandar, Knežević, Aleksandra, Karalić, Danijela, Soldatović, Ivan, Popović, Branka, Milašin, Jelena, Andrić, Miroslav, "Pro-inflammatory cytokine levels in human apical periodontitis: Correlation with clinical and histological findings" in Australian Endodontic Journal, 41, no. 2 (2015):72-77,
https://doi.org/10.1111/aej.12072 . .
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