TY  - JOUR
AU  - Stojić, Vanja
AU  - Glišić, Branislav
AU  - Đukić, Ljiljana
AU  - Prokić, Bogomir
AU  - Janović, Aleksa
AU  - Stamenković, Zorana
AU  - Milutinović-Smiljanić, Sanja
AU  - Danilović, Vesna
AU  - Brković, Božidar
AU  - Roganović, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2512
AB  - Objective: We aimed to investigate alteration in cellular signaling mediated by vascular endothelial growth factor (VEGF) and parameters of oxidative stress/nitric oxide generation, superoxide dismutase (SOD) and neuronal nitric oxide synthase (nNOS), underlying altered functional mechanical loading of TMJ (temporomandibular joint) during lateral mandibular deviation. Design: Thirty-eight 5-week-old male Wistar rats were divided into experimental group, which received acrylic resin appliance that shifted mandible to the left during closure, and control group. Computed tomography and histomorphometry were used for condyle analyses, while samples of condyle, synovial membrane and m. masseter were analyzed with enzyme-linked immunosorbent assay and spectrophotometry to determine VEGF and nNOS protein concentrations, and SOD activity. Results: Experimental group of rats developed smaller and asymmetrical mandibles. Less of new bone and cartilage formation and larger bone marrow cavities area were found in the experimental group. Higher VEGF expression in condyle and m. masseter as well as higher nNOS expression in m. masseter and synovial membrane were found in the experimental compared to the control group. Alteration of SOD activity was found in m. masseter and synovial membrane in the experimental group. Conclusions: Lateral mandibular deviation induces mandibular and condylar morphological changes as well as significant cellular signaling alterations in condyle, synovial membrane and masticatory muscle. Cellular VEGF protein overexpression and oxidative stress/nitric oxide disbalance could be the mechanisms underlying unbalanced functional TMJ loading due to mandibular deviation.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle
VL  - 110
DO  - 10.1016/j.archoralbio.2019.104599
ER  - 

@article{
author = "Stojić, Vanja and Glišić, Branislav and Đukić, Ljiljana and Prokić, Bogomir and Janović, Aleksa and Stamenković, Zorana and Milutinović-Smiljanić, Sanja and Danilović, Vesna and Brković, Božidar and Roganović, Jelena",
year = "2020",
abstract = "Objective: We aimed to investigate alteration in cellular signaling mediated by vascular endothelial growth factor (VEGF) and parameters of oxidative stress/nitric oxide generation, superoxide dismutase (SOD) and neuronal nitric oxide synthase (nNOS), underlying altered functional mechanical loading of TMJ (temporomandibular joint) during lateral mandibular deviation. Design: Thirty-eight 5-week-old male Wistar rats were divided into experimental group, which received acrylic resin appliance that shifted mandible to the left during closure, and control group. Computed tomography and histomorphometry were used for condyle analyses, while samples of condyle, synovial membrane and m. masseter were analyzed with enzyme-linked immunosorbent assay and spectrophotometry to determine VEGF and nNOS protein concentrations, and SOD activity. Results: Experimental group of rats developed smaller and asymmetrical mandibles. Less of new bone and cartilage formation and larger bone marrow cavities area were found in the experimental group. Higher VEGF expression in condyle and m. masseter as well as higher nNOS expression in m. masseter and synovial membrane were found in the experimental compared to the control group. Alteration of SOD activity was found in m. masseter and synovial membrane in the experimental group. Conclusions: Lateral mandibular deviation induces mandibular and condylar morphological changes as well as significant cellular signaling alterations in condyle, synovial membrane and masticatory muscle. Cellular VEGF protein overexpression and oxidative stress/nitric oxide disbalance could be the mechanisms underlying unbalanced functional TMJ loading due to mandibular deviation.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle",
volume = "110",
doi = "10.1016/j.archoralbio.2019.104599"
}

Stojić, V., Glišić, B., Đukić, L., Prokić, B., Janović, A., Stamenković, Z., Milutinović-Smiljanić, S., Danilović, V., Brković, B.,& Roganović, J.. (2020). Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 110.
https://doi.org/10.1016/j.archoralbio.2019.104599

Stojić V, Glišić B, Đukić L, Prokić B, Janović A, Stamenković Z, Milutinović-Smiljanić S, Danilović V, Brković B, Roganović J. Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle. in Archives of Oral Biology. 2020;110.
doi:10.1016/j.archoralbio.2019.104599 .

Stojić, Vanja, Glišić, Branislav, Đukić, Ljiljana, Prokić, Bogomir, Janović, Aleksa, Stamenković, Zorana, Milutinović-Smiljanić, Sanja, Danilović, Vesna, Brković, Božidar, Roganović, Jelena, "Mandibular lateral deviation induces alteration in vascular endothelial growth factor expression and oxidative stress/nitric oxide generation in rat condyle, synovial membrane and masseter muscle" in Archives of Oral Biology, 110 (2020),
https://doi.org/10.1016/j.archoralbio.2019.104599 . .

TY  - JOUR
AU  - Ilić, Jugoslav
AU  - Radović, Katarina
AU  - Brković, Božidar
AU  - Vasić, Jugoslav
AU  - Roganović, Jelena
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2588
AB  - Introduction/Objective. We aimed to investigate the effects of diabetes mellitus (DM) on rat dental pulp repair by measuring time-dependent changes in expressions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) following direct pulp capping. Methods. Two groups, each of 20 Wistar rats, received either streptozotocin (for DM induction) or the same volume of sterile saline. A week later, the pulp of maxillary and mandibular right incisors in diabetic and non-diabetic groups were exposed and capped with calcium hydroxide in order to provoke reparative response. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates one and seven days after the pulp capping, using enzyme-linked immunosorbent assays. Results. Diabetic state per se increased VEGF level, with a peak at first day after the pulp capping (19.3 ± 0.9 pg/mg, p < 0.001), but did not affect BMP 2 levels. Significant increase of BMP 2 expression was noticed on the seventh day in capped pulp, but only in diabetic rats (16.7 ± 1 pg/mg, p = 0.001). Positive correlation between VEGF and BMP 2 was found on the seventh day following capping, only in diabetic pulp (r = 0.905, p = 0.003). Conclusion. Diabetes-induced increase in VEGF expression reflects changes in the inflammatory phase of pulp repair in DM. Increase in BMP 2 expression suggest that stimulating effect of calcium hydroxide appears seven days after diabetic pulp capping.
AB  - Uvod/Cilj Cilj ove studije bio je da se ispita efekat dijabetesa melitusa na reparaciju zubne pulpe pacova utvrđivanjem vremenski zavisnih promena u ekspresiji vaskularnog endotelnog faktora rasta (VEGF) i kostnog morfogenetskog proteina 2 (BMP 2) posle direktnog prekrivanja pulpe. Metode Istraživanje je sprovedeno na pacovima soja vistar, podeljenim u dve grupe od po 20 životinja, pri čemu je jedna grupa dobila streptozotocin (za indukciju dijabetesa melitusa), a druga sterilni fiziološki rastvor u istoj zapremini. Posle nedelju dana pulpe maksilarnih i mandibularnih donjih inciziva kod dijabetičnih i nedijabetičnih životinja su eksponirane i odmah zatim prekrivene kalcijum-hidroksidom da bi se izazvao reparatorni odgovor. Nivoi VEGF i BMP 2 su utvrđivani u lizatima pulpnog tkiva, prvog i sedmog dana posle direktnog prekrivanja imunoenzimskim testom ELISA. Rezultati Dijabetično stanje je dovelo do rasta nivoa VEGF, sa maksimumom utvrđenim prvog dana posle prekrivanja pulpe (19,3 ± 0,9 pg/mg, p < 0,001), ali nije uticalo na nivoe BMP 2. Značajan porast BMP 2 je utvrđen sedmog dana posle prekrivanja pulpe, ali samo kod dijabetičnih pacova (16,7 ± 1 pg/mg, p = 0,001). Kod ovih životinja u istom periodu posle prekrivanja nađena je pozitivna korelacija između nivoa VEGF i BMP 2 (r = 0,905, p = 0,003). Zaključak Dijabetesom indukovan porast ekspresije VEGF ukazuje na promene u inflamatornoj fazi pulpne reparacije. Porast ekspresije BMP 2 ukazuje da se stimulativan reparatorni efekat kalcijum-hidroksida javlja sedmog dana posle prekrivanja dijabetične pulpe.
PB  - Beograd: Srpsko lekarsko društvo
T2  - Srpski arhiv za celokupno lekarstvo
T1  - The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2
T1  - Reparacija dijabetične zubne pulpe – uloga vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina 2
VL  - 148
IS  - 11-12
SP  - 673
EP  - 678
DO  - 10.2298/SARH200228057I
ER  - 

@article{
author = "Ilić, Jugoslav and Radović, Katarina and Brković, Božidar and Vasić, Jugoslav and Roganović, Jelena",
year = "2020",
abstract = "Introduction/Objective. We aimed to investigate the effects of diabetes mellitus (DM) on rat dental pulp repair by measuring time-dependent changes in expressions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) following direct pulp capping. Methods. Two groups, each of 20 Wistar rats, received either streptozotocin (for DM induction) or the same volume of sterile saline. A week later, the pulp of maxillary and mandibular right incisors in diabetic and non-diabetic groups were exposed and capped with calcium hydroxide in order to provoke reparative response. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates one and seven days after the pulp capping, using enzyme-linked immunosorbent assays. Results. Diabetic state per se increased VEGF level, with a peak at first day after the pulp capping (19.3 ± 0.9 pg/mg, p < 0.001), but did not affect BMP 2 levels. Significant increase of BMP 2 expression was noticed on the seventh day in capped pulp, but only in diabetic rats (16.7 ± 1 pg/mg, p = 0.001). Positive correlation between VEGF and BMP 2 was found on the seventh day following capping, only in diabetic pulp (r = 0.905, p = 0.003). Conclusion. Diabetes-induced increase in VEGF expression reflects changes in the inflammatory phase of pulp repair in DM. Increase in BMP 2 expression suggest that stimulating effect of calcium hydroxide appears seven days after diabetic pulp capping., Uvod/Cilj Cilj ove studije bio je da se ispita efekat dijabetesa melitusa na reparaciju zubne pulpe pacova utvrđivanjem vremenski zavisnih promena u ekspresiji vaskularnog endotelnog faktora rasta (VEGF) i kostnog morfogenetskog proteina 2 (BMP 2) posle direktnog prekrivanja pulpe. Metode Istraživanje je sprovedeno na pacovima soja vistar, podeljenim u dve grupe od po 20 životinja, pri čemu je jedna grupa dobila streptozotocin (za indukciju dijabetesa melitusa), a druga sterilni fiziološki rastvor u istoj zapremini. Posle nedelju dana pulpe maksilarnih i mandibularnih donjih inciziva kod dijabetičnih i nedijabetičnih životinja su eksponirane i odmah zatim prekrivene kalcijum-hidroksidom da bi se izazvao reparatorni odgovor. Nivoi VEGF i BMP 2 su utvrđivani u lizatima pulpnog tkiva, prvog i sedmog dana posle direktnog prekrivanja imunoenzimskim testom ELISA. Rezultati Dijabetično stanje je dovelo do rasta nivoa VEGF, sa maksimumom utvrđenim prvog dana posle prekrivanja pulpe (19,3 ± 0,9 pg/mg, p < 0,001), ali nije uticalo na nivoe BMP 2. Značajan porast BMP 2 je utvrđen sedmog dana posle prekrivanja pulpe, ali samo kod dijabetičnih pacova (16,7 ± 1 pg/mg, p = 0,001). Kod ovih životinja u istom periodu posle prekrivanja nađena je pozitivna korelacija između nivoa VEGF i BMP 2 (r = 0,905, p = 0,003). Zaključak Dijabetesom indukovan porast ekspresije VEGF ukazuje na promene u inflamatornoj fazi pulpne reparacije. Porast ekspresije BMP 2 ukazuje da se stimulativan reparatorni efekat kalcijum-hidroksida javlja sedmog dana posle prekrivanja dijabetične pulpe.",
publisher = "Beograd: Srpsko lekarsko društvo",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2, Reparacija dijabetične zubne pulpe – uloga vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina 2",
volume = "148",
number = "11-12",
pages = "673-678",
doi = "10.2298/SARH200228057I"
}

Ilić, J., Radović, K., Brković, B., Vasić, J.,& Roganović, J.. (2020). The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2. in Srpski arhiv za celokupno lekarstvo
Beograd: Srpsko lekarsko društvo., 148(11-12), 673-678.
https://doi.org/10.2298/SARH200228057I

Ilić J, Radović K, Brković B, Vasić J, Roganović J. The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2. in Srpski arhiv za celokupno lekarstvo. 2020;148(11-12):673-678.
doi:10.2298/SARH200228057I .

Ilić, Jugoslav, Radović, Katarina, Brković, Božidar, Vasić, Jugoslav, Roganović, Jelena, "The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2" in Srpski arhiv za celokupno lekarstvo, 148, no. 11-12 (2020):673-678,
https://doi.org/10.2298/SARH200228057I . .

TY  - JOUR
AU  - Jurišić, Tamara
AU  - Milić, Marija
AU  - Todorović, Vladimir S.
AU  - Živković, Marko
AU  - Jurišić, Milan
AU  - Milić-Lemić, Aleksandra
AU  - Tihaček-Šojić, Ljiljana
AU  - Brković, Božidar
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2497
AB  - Background/Aim. Alveolar ridge dimensional alterations following tooth extraction in the anterior maxilla often result in an inadequate bone volume for a correct implant placement. In order to obtain optimal bone volume various bone graft substitutes have become commercially available and widely used for socket grafting. The aim of this study was to examine and compare long-term clinical outcomes of dental implant therapy in the maxillary esthetic zone, after socket grafting with beta-tricalcium phosphate (TCP) combined with collagen type I, either with or without barrier membrane and flap surgery, after a 12-month follow-up. Methods. Twenty healthy patients were allocated to either C group (beta-TCP and type I collagen without mucoperiosteal flap coverage) or C+M group (beta-TCP and type I collagen barrier membrane with mucoperiosteal flap coverage). Following clinical parameters were assessed: implant stability (evaluated by a resonance frequency analysis - RFA), periimplant soft tissue stability (sulcus bleeding index - SBI, Mombelli sulcus bleeding index - MBI, periimplant sulcus depth, keratinized gingiva width, gingival level) and marginal bone level at the retroalveolar radiograms. Results. Within C+M group, RFA values significantly increased 12 weeks after implant installation compared to primary RFA values. Comparison between investigated groups showed a significantly reduced keratinized gingiva width in the C+M group compared to the C group after 3, 6, 9 and 12 months. Comparison between groups revealed significantly lower gingival level values in the C+M group at 9th and 12th month when compared to the C group. Conclusion. Implant treatment in the anterior maxilla could be effective when using a 9 months alveolar ridge preservation healing with combined treatment with beta-tricalcium phosphate and type I collagen, with regard to the peri-implant soft and hard tissue stability.
AB  - Uvod/Cilj. Posle ekstrakcije zuba, dimenzionalne promene alveolarnog grebena u estetskoj regiji gornje vilice za posledicu često imaju nedovoljnu količinu kosti za ugradnju zubnih implanata. U vezi sa tim, primenjuju se različiti koštani zamenici sa ciljem očuvanja dimenzija alveolarnog grebena posle ekstrakcije zuba. Cilj rada bio je da se, posle prezervacije alveolarnog grebena beta-trikalcijum fosfatom (TCP) sa kolagenom tip 1, sa barijernom membranom i mukoperiostalnim režnjem i bez nje, ispitaju i uporede klinički ishodi zarastanja posle ugradnje zubnih implanata u estetskoj regiji gornje vilice, tokom jednogodišnjeg perioda praćenja. Metode. Dvadeset zdravih bolesnika podeljeno je u dve grupe: C (beta TCP/kolagen tip 1 bez barijerne membrane i mukoperiostalnog režnja) i C+M (beta TCP/kolagen tip 1 sa barijernom membranom i mukoperiostalnim režnjem). Praćeni su uobičajeni klinički parametri ishoda terapije: implantna stabilnost (analiza rezonantne frekvence), stanje mekih tkiva (indeks krvarenja, plak indeks, širina pripojne mukoze, recesija gingive) i nivo periimplantnog koštanog tkiva na retroalveolarnom radiogramu. Rezultati. U C+M grupi, implantna stabilnost posle 12 nedelja bila je značajno veća u odnosu na primarnu stabilnost. U C+M grupi, širina keratinizovane gingive bila je značajno manja posle 3, 6, 9 i 12 meseci u odnosu na C grupu. Recesija gingive bila je značajno veća u C+M grupi u odnosu na C grupu posle 9 i 12 meseci. Zaključak. Razmatrajući stabilnost mekog i tvrdog periimplantnog tkiva, terapija zubnim implantima može biti uspešna prilikom ugradnje u estetskoj regiji gornje vilice.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Peri-implant soft and hard tissue condition after alveolar ridge preservation with beta-tricalcium phosphate/type I collagen in the maxillary esthetic zone: A 1-year follow-up study
T1  - Stanje tvrdog i mekog periimplantnog tkiva u estetskoj regiji gornje vilice posle prezervacije alveolarnog grebena beta-trikalcijum fosfatom sa kolagenom tip I - studija sa jednogodišnjim periodom praćenja
VL  - 77
IS  - 1
SP  - 22
EP  - 28
DO  - 10.2298/VSP180128047J
ER  - 

@article{
author = "Jurišić, Tamara and Milić, Marija and Todorović, Vladimir S. and Živković, Marko and Jurišić, Milan and Milić-Lemić, Aleksandra and Tihaček-Šojić, Ljiljana and Brković, Božidar",
year = "2020",
abstract = "Background/Aim. Alveolar ridge dimensional alterations following tooth extraction in the anterior maxilla often result in an inadequate bone volume for a correct implant placement. In order to obtain optimal bone volume various bone graft substitutes have become commercially available and widely used for socket grafting. The aim of this study was to examine and compare long-term clinical outcomes of dental implant therapy in the maxillary esthetic zone, after socket grafting with beta-tricalcium phosphate (TCP) combined with collagen type I, either with or without barrier membrane and flap surgery, after a 12-month follow-up. Methods. Twenty healthy patients were allocated to either C group (beta-TCP and type I collagen without mucoperiosteal flap coverage) or C+M group (beta-TCP and type I collagen barrier membrane with mucoperiosteal flap coverage). Following clinical parameters were assessed: implant stability (evaluated by a resonance frequency analysis - RFA), periimplant soft tissue stability (sulcus bleeding index - SBI, Mombelli sulcus bleeding index - MBI, periimplant sulcus depth, keratinized gingiva width, gingival level) and marginal bone level at the retroalveolar radiograms. Results. Within C+M group, RFA values significantly increased 12 weeks after implant installation compared to primary RFA values. Comparison between investigated groups showed a significantly reduced keratinized gingiva width in the C+M group compared to the C group after 3, 6, 9 and 12 months. Comparison between groups revealed significantly lower gingival level values in the C+M group at 9th and 12th month when compared to the C group. Conclusion. Implant treatment in the anterior maxilla could be effective when using a 9 months alveolar ridge preservation healing with combined treatment with beta-tricalcium phosphate and type I collagen, with regard to the peri-implant soft and hard tissue stability., Uvod/Cilj. Posle ekstrakcije zuba, dimenzionalne promene alveolarnog grebena u estetskoj regiji gornje vilice za posledicu često imaju nedovoljnu količinu kosti za ugradnju zubnih implanata. U vezi sa tim, primenjuju se različiti koštani zamenici sa ciljem očuvanja dimenzija alveolarnog grebena posle ekstrakcije zuba. Cilj rada bio je da se, posle prezervacije alveolarnog grebena beta-trikalcijum fosfatom (TCP) sa kolagenom tip 1, sa barijernom membranom i mukoperiostalnim režnjem i bez nje, ispitaju i uporede klinički ishodi zarastanja posle ugradnje zubnih implanata u estetskoj regiji gornje vilice, tokom jednogodišnjeg perioda praćenja. Metode. Dvadeset zdravih bolesnika podeljeno je u dve grupe: C (beta TCP/kolagen tip 1 bez barijerne membrane i mukoperiostalnog režnja) i C+M (beta TCP/kolagen tip 1 sa barijernom membranom i mukoperiostalnim režnjem). Praćeni su uobičajeni klinički parametri ishoda terapije: implantna stabilnost (analiza rezonantne frekvence), stanje mekih tkiva (indeks krvarenja, plak indeks, širina pripojne mukoze, recesija gingive) i nivo periimplantnog koštanog tkiva na retroalveolarnom radiogramu. Rezultati. U C+M grupi, implantna stabilnost posle 12 nedelja bila je značajno veća u odnosu na primarnu stabilnost. U C+M grupi, širina keratinizovane gingive bila je značajno manja posle 3, 6, 9 i 12 meseci u odnosu na C grupu. Recesija gingive bila je značajno veća u C+M grupi u odnosu na C grupu posle 9 i 12 meseci. Zaključak. Razmatrajući stabilnost mekog i tvrdog periimplantnog tkiva, terapija zubnim implantima može biti uspešna prilikom ugradnje u estetskoj regiji gornje vilice.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Peri-implant soft and hard tissue condition after alveolar ridge preservation with beta-tricalcium phosphate/type I collagen in the maxillary esthetic zone: A 1-year follow-up study, Stanje tvrdog i mekog periimplantnog tkiva u estetskoj regiji gornje vilice posle prezervacije alveolarnog grebena beta-trikalcijum fosfatom sa kolagenom tip I - studija sa jednogodišnjim periodom praćenja",
volume = "77",
number = "1",
pages = "22-28",
doi = "10.2298/VSP180128047J"
}

Jurišić, T., Milić, M., Todorović, V. S., Živković, M., Jurišić, M., Milić-Lemić, A., Tihaček-Šojić, L.,& Brković, B.. (2020). Peri-implant soft and hard tissue condition after alveolar ridge preservation with beta-tricalcium phosphate/type I collagen in the maxillary esthetic zone: A 1-year follow-up study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 77(1), 22-28.
https://doi.org/10.2298/VSP180128047J

Jurišić T, Milić M, Todorović VS, Živković M, Jurišić M, Milić-Lemić A, Tihaček-Šojić L, Brković B. Peri-implant soft and hard tissue condition after alveolar ridge preservation with beta-tricalcium phosphate/type I collagen in the maxillary esthetic zone: A 1-year follow-up study. in Vojnosanitetski pregled. 2020;77(1):22-28.
doi:10.2298/VSP180128047J .

Jurišić, Tamara, Milić, Marija, Todorović, Vladimir S., Živković, Marko, Jurišić, Milan, Milić-Lemić, Aleksandra, Tihaček-Šojić, Ljiljana, Brković, Božidar, "Peri-implant soft and hard tissue condition after alveolar ridge preservation with beta-tricalcium phosphate/type I collagen in the maxillary esthetic zone: A 1-year follow-up study" in Vojnosanitetski pregled, 77, no. 1 (2020):22-28,
https://doi.org/10.2298/VSP180128047J . .

TY  - JOUR
AU  - Vučetić, Milan
AU  - Roganović, Jelena
AU  - Freilich, M.
AU  - Shafer, D.
AU  - Milić, Marija
AU  - Đukić, Ljiljana
AU  - Petrović, Nina
AU  - Marković, Evgenija
AU  - Marković, Aleksa
AU  - Brković, Božidar
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2481
AB  - Objective: To evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. Material and methods: Twenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL-1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded. Results: MiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance. Conclusion: Delayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. Clinical relevance: Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset.
PB  - Springer
T2  - Clinical Oral Investigations
T1  - Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort
DO  - 10.1007/s00784-020-03366-6
ER  - 

@article{
author = "Vučetić, Milan and Roganović, Jelena and Freilich, M. and Shafer, D. and Milić, Marija and Đukić, Ljiljana and Petrović, Nina and Marković, Evgenija and Marković, Aleksa and Brković, Božidar",
year = "2020",
abstract = "Objective: To evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. Material and methods: Twenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL-1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded. Results: MiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance. Conclusion: Delayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. Clinical relevance: Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset.",
publisher = "Springer",
journal = "Clinical Oral Investigations",
title = "Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort",
doi = "10.1007/s00784-020-03366-6"
}

Vučetić, M., Roganović, J., Freilich, M., Shafer, D., Milić, M., Đukić, L., Petrović, N., Marković, E., Marković, A.,& Brković, B.. (2020). Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort. in Clinical Oral Investigations
Springer..
https://doi.org/10.1007/s00784-020-03366-6

Vučetić M, Roganović J, Freilich M, Shafer D, Milić M, Đukić L, Petrović N, Marković E, Marković A, Brković B. Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort. in Clinical Oral Investigations. 2020;.
doi:10.1007/s00784-020-03366-6 .

Vučetić, Milan, Roganović, Jelena, Freilich, M., Shafer, D., Milić, Marija, Đukić, Ljiljana, Petrović, Nina, Marković, Evgenija, Marković, Aleksa, Brković, Božidar, "Bone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomfort" in Clinical Oral Investigations (2020),
https://doi.org/10.1007/s00784-020-03366-6 . .

TY  - JOUR
AU  - Ćetković, Dejan
AU  - Milić, Marija
AU  - Biočanin, Vladimir
AU  - Brajić, Ivana
AU  - Ćalasan, Dejan
AU  - Radović, Katarina
AU  - Živković, Rade
AU  - Brković, Božidar
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2448
AB  - Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed.
AB  - Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study
T1  - Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija
VL  - 76
IS  - 10
SP  - 1045
EP  - 1053
DO  - 10.2298/VSP170511013C
ER  - 

@article{
author = "Ćetković, Dejan and Milić, Marija and Biočanin, Vladimir and Brajić, Ivana and Ćalasan, Dejan and Radović, Katarina and Živković, Rade and Brković, Božidar",
year = "2019",
abstract = "Bacground/Aim. The efficient dental anesthesia, which is related to the clinically adequate depth, duration and the width of anesthetic field, is an important prerequisite for successful dental treatment. The aim of this study was to investigate and compare the pulpal anesthesia and cardiovascular parameters after the anterior middle superior alveolar (AMSA) nerve block with 4% articaine with epinephrine administered by conventional cartridge-syringe and computer-controlled local anesthetic delivery system (CCLADS). Methods. This controlled double-blind cross-over randomized clinical study included 38 healthy volunteers. Efficacy of pulpal anesthesia after the AMSA nerve block was evaluated by measuring a success rate, onset and duration of pulpal anesthesia, using an electrical pulp tester. The parameters of cardiovascular function (systolic and diastolic blood pressure, heart rate) were monitored noninvasively. Results. Successful pulpal anesthesia of all tested teeth was obtained in 57.9% participants with CCLADS and in 44.7% participants with conventional syringe. The onset time was not significantly different between two investigated groups. The pulpal anesthesia duration was not significantly different neither within nor between investigated groups. The systolic and diastolic blood pressures were significantly decreased in both investigated groups, in comparison with the baseline values. Heart rate significantly decreased within CCLADS from 10th to 30th minute when compared to baseline. Conclusion. The efficacy of pulpal anesthesia and safety of cardiovascular profile of 0.6 mL of articaine with epinephrine (1:100.000) delivered with CCLADS were improved in comparison to the conventional syringe delivery. Significant changes of cardiovascular function were not observed., Uvod/Cilj. Efikasna zubna anestezija u pogledu klinički adekvatne dubine, trajanja i širine anestetičkog polja je važan preduslov za uspešno zubno lečenje. Cilj rada bio je ispitivanje i upoređivanje parametra anestezije zubne pulpe i kardiovaskularnih parametra posle gornje prednje i srednje alveolarne (AMSA) sprovodne anestezije postignute 4% artikainom sa epinefrinom, primenom standardne karpulbrizgalice i kompjuterski kontrolisanog sistema za primenu anestetičkog rastvora (CCLADS). Metode. U ovom randomizovanom, prospektivnom, kontrolisanom, dvostruko slepom ukrštenom kliničkom istraživanju učestvovalo je 38 ispitanika. Kvalitet anestezije zubne pulpe posle AMSA anestezije praćen je na osnovu uspešnosti, latentnog perioda i trajanja anestezije zubne pulpe, primenom električnog pulp-testera. Parametri kardiovaskularne funkcije (sistolni i dijastolni krvni pritisak, srčana frekvencija) praćeni su neinvazivno, primenom aparata za monitoring. Rezultati. Uspešna anestezija zubne pulpe svih ispitivanih zuba bila je prisutna kod 57,9% ispitanika posle kod CCLADS i kod 44,7% ispitanika posle primene standardne karpul-brizgalice. Latentni period i trajanje anestezije zubne pulpe nisu se značajno razlikovali između ispitivanih grupa. Sistolni i dijastolni pritisak bili su značajno sniženi u praćenim vremenskim intervalima u odnosu na početne vrednosti. Srčana frekvencija je bila značajno snižena kod CCLADS grupe od 10 do 30 minuta u odnosu na početne vrednosti. Zaključak. Kontrolisanom kompjuterizovanom primenom (CCLADS) 0,6 mL 4% artikaina sa epinefrinom (1:100,000) za AMSA sprovodnu anesteziju, postignut je bolji kvalitet anestezije zubne pulpe u odnosu na primenu artikaina sa epinefrinom standardnom karpul brizgalicom. Nisu uočene bitne promene funkcija kardiovaskularnog sistema.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study, Efikasnost i sigurnost 4% artikaina sa epinefrinom za gornji prednji i srednji alveolarni nervni blok primenom kompjuterski kontrolisanog sistema i standardnog pristupa za primenu anestetičkog rastvora - prospektivna, randomizovana, kontrolisana, dvosturko slepa, ukrštena klinička studija",
volume = "76",
number = "10",
pages = "1045-1053",
doi = "10.2298/VSP170511013C"
}

Ćetković, D., Milić, M., Biočanin, V., Brajić, I., Ćalasan, D., Radović, K., Živković, R.,& Brković, B.. (2019). Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(10), 1045-1053.
https://doi.org/10.2298/VSP170511013C

Ćetković D, Milić M, Biočanin V, Brajić I, Ćalasan D, Radović K, Živković R, Brković B. Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study. in Vojnosanitetski pregled. 2019;76(10):1045-1053.
doi:10.2298/VSP170511013C .

Ćetković, Dejan, Milić, Marija, Biočanin, Vladimir, Brajić, Ivana, Ćalasan, Dejan, Radović, Katarina, Živković, Rade, Brković, Božidar, "Efficacy and safety of 4% articaine with epinephrine for the anterior middle superior alveolar nerve block comparing to the computer controlled and conventional anesthetic delivery: Prospective, randomized, cross-over clinical study" in Vojnosanitetski pregled, 76, no. 10 (2019):1045-1053,
https://doi.org/10.2298/VSP170511013C . .

TY  - JOUR
AU  - Baćević, Miljana
AU  - Brković, Božidar
AU  - Lamber, France
AU  - Đukić, Ljiljana
AU  - Petrović, Nina
AU  - Roganović, Jelena
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2388
AB  - Objective: Leukocyte- and platelet-rich fibrin (L-PRF) represents a natural, low-cost product which may promote tissue healing by mechanisms not fully elucidated. Diabetes mellitus (DM) disrupts bone healing by inducing inflammation and oxidative stress (OS), mechanisms regulated by microRNAs (miRs). The aim of the present study was to investigate the microRNA-21 (miR-21) involvement in diabetic bone regeneration using L-PRF alone or in combination with a standard grafting material. Design: After the induction of diabetes (alloxan 100 mg/kg), four cranial osteotomies were made in diabetic (n = 12) and non-diabetic (n = 12) rabbits: one was left empty and the remaining three were grafted with L-PRF, bovine hydroxyapatite (Bio-Oss((R))) and L-PRF + Bio-Oss((R)). Two and eight weeks postoperatively, the samples were harvested for miR-21 expression (Real-time RT-PCR) and enzyme-linked immunosorbent assay analyses. Results: Diabetic rabbits showed decreased miR-21 and matrix metalloproteinase-9 (MMP-9) protein expression while increased malondialdehyde (MDA) levels two weeks postoperatively; however, there were no significant differences in miR-21 and MMP-9 levels between diabetic and non-diabetic rabbits in samples taken eight weeks postoperatively. Application of L-PRF and L-PRF + Bio-Oss((R)) improved miR-21 and MMP-9 and decreased MDA levels while Bio-Oss((R)) alone enhanced superoxide dismutase (SOD) activity levels in diabetic rabbits. Conclusion: L-PRF alone or in combination with bovine hydroxyapatite as bone graft could be beneficial in DM since it seems to improve inflammation-modulatory miR-21 expression and decreases oxidative stress.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Archives of Oral Biology
T1  - Leukocyte- and platelet-rich fibrin as graft material improves microRNA-21 expression and decreases oxidative stress in the calvarial defects of diabetic rabbits
VL  - 102
SP  - 231
EP  - 237
DO  - 10.1016/j.archoralbio.2019.05.005
ER  - 

@article{
author = "Baćević, Miljana and Brković, Božidar and Lamber, France and Đukić, Ljiljana and Petrović, Nina and Roganović, Jelena",
year = "2019",
abstract = "Objective: Leukocyte- and platelet-rich fibrin (L-PRF) represents a natural, low-cost product which may promote tissue healing by mechanisms not fully elucidated. Diabetes mellitus (DM) disrupts bone healing by inducing inflammation and oxidative stress (OS), mechanisms regulated by microRNAs (miRs). The aim of the present study was to investigate the microRNA-21 (miR-21) involvement in diabetic bone regeneration using L-PRF alone or in combination with a standard grafting material. Design: After the induction of diabetes (alloxan 100 mg/kg), four cranial osteotomies were made in diabetic (n = 12) and non-diabetic (n = 12) rabbits: one was left empty and the remaining three were grafted with L-PRF, bovine hydroxyapatite (Bio-Oss((R))) and L-PRF + Bio-Oss((R)). Two and eight weeks postoperatively, the samples were harvested for miR-21 expression (Real-time RT-PCR) and enzyme-linked immunosorbent assay analyses. Results: Diabetic rabbits showed decreased miR-21 and matrix metalloproteinase-9 (MMP-9) protein expression while increased malondialdehyde (MDA) levels two weeks postoperatively; however, there were no significant differences in miR-21 and MMP-9 levels between diabetic and non-diabetic rabbits in samples taken eight weeks postoperatively. Application of L-PRF and L-PRF + Bio-Oss((R)) improved miR-21 and MMP-9 and decreased MDA levels while Bio-Oss((R)) alone enhanced superoxide dismutase (SOD) activity levels in diabetic rabbits. Conclusion: L-PRF alone or in combination with bovine hydroxyapatite as bone graft could be beneficial in DM since it seems to improve inflammation-modulatory miR-21 expression and decreases oxidative stress.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Archives of Oral Biology",
title = "Leukocyte- and platelet-rich fibrin as graft material improves microRNA-21 expression and decreases oxidative stress in the calvarial defects of diabetic rabbits",
volume = "102",
pages = "231-237",
doi = "10.1016/j.archoralbio.2019.05.005"
}

Baćević, M., Brković, B., Lamber, F., Đukić, L., Petrović, N.,& Roganović, J.. (2019). Leukocyte- and platelet-rich fibrin as graft material improves microRNA-21 expression and decreases oxidative stress in the calvarial defects of diabetic rabbits. in Archives of Oral Biology
Pergamon-Elsevier Science Ltd, Oxford., 102, 231-237.
https://doi.org/10.1016/j.archoralbio.2019.05.005

Baćević M, Brković B, Lamber F, Đukić L, Petrović N, Roganović J. Leukocyte- and platelet-rich fibrin as graft material improves microRNA-21 expression and decreases oxidative stress in the calvarial defects of diabetic rabbits. in Archives of Oral Biology. 2019;102:231-237.
doi:10.1016/j.archoralbio.2019.05.005 .

Baćević, Miljana, Brković, Božidar, Lamber, France, Đukić, Ljiljana, Petrović, Nina, Roganović, Jelena, "Leukocyte- and platelet-rich fibrin as graft material improves microRNA-21 expression and decreases oxidative stress in the calvarial defects of diabetic rabbits" in Archives of Oral Biology, 102 (2019):231-237,
https://doi.org/10.1016/j.archoralbio.2019.05.005 . .

TY  - JOUR
AU  - Vasović, Dina
AU  - Divović, Branka
AU  - Treven, Marco
AU  - Knutson, Daniel
AU  - Steudle, Friederike
AU  - Scholze, Petra
AU  - Obradović, Aleksandar
AU  - Fabjan, Jure
AU  - Brković, Božidar
AU  - Sieghart, Werner
AU  - Ernst, Margot
AU  - Cook, James
AU  - Savić, Miroslav
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2384
AB  - gamma-Aminobutyric acid type A (GABA(A)) receptors containing the alpha 6 subunit are located in trigeminal ganglia, and their reduction by small interfering RNA increases inflammatory temporomandibular and myofascial pain in rats. We thus hypothesized that enhancing their activity may help in neuropathic syndromes originating from the trigeminal system. Here, we performed a detailed electrophysiological and pharmacokinetic analysis of two recently developed deuterated structurally similar pyrazoloquinolinone compounds. DK-I-56-1 at concentrations below 1 mu M enhanced gamma-aminobutyric acid (GABA) currents at recombinant rat alpha 6 beta 3 gamma 2, alpha 6 beta 3 delta and alpha 6 beta 3 receptors, whereas it was inactive at most GABA(A) receptor subtypes containing other alpha subunits. DK-I-87-1 at concentrations below 1 mu M was inactive at alpha 6-containing receptors and only weakly modulated other GABA(A) receptors investigated. Both plasma and brain tissue kinetics of DK-I-56-1 were relatively slow, with half-lives of 6 and 13 hr, respectively, enabling the persistence of estimated free brain concentrations in the range 10-300 nM throughout a 24-hr period. Results obtained in two protocols of chronic constriction injury of the infraorbital nerve in rats dosed intraperitoneally with DK-I-56-1 during 14 days after surgery or with DK-I-56-1 or DK-I-87-1 during 14 days after trigeminal neuropathy were already established, demonstrated that DK-I-56-1 but not DK-I-87-1 significantly reduced the hypersensitivity response to von Frey filaments. Significance Neuropathic pain induced by trigeminal nerve damage is poorly controlled by current treatments. DK-I-56-1 that positively modulates alpha 6 GABA(A) receptors is appropriate for repeated administration and thus may represent a novel treatment option against the development and maintenance of trigeminal neuropathic pain.
PB  - Wiley, Hoboken
T2  - European Journal of Pain
T1  - Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of alpha 6 GABA(A) receptors
VL  - 23
IS  - 5
SP  - 973
EP  - 984
DO  - 10.1002/ejp.1365
ER  - 

@article{
author = "Vasović, Dina and Divović, Branka and Treven, Marco and Knutson, Daniel and Steudle, Friederike and Scholze, Petra and Obradović, Aleksandar and Fabjan, Jure and Brković, Božidar and Sieghart, Werner and Ernst, Margot and Cook, James and Savić, Miroslav",
year = "2019",
abstract = "gamma-Aminobutyric acid type A (GABA(A)) receptors containing the alpha 6 subunit are located in trigeminal ganglia, and their reduction by small interfering RNA increases inflammatory temporomandibular and myofascial pain in rats. We thus hypothesized that enhancing their activity may help in neuropathic syndromes originating from the trigeminal system. Here, we performed a detailed electrophysiological and pharmacokinetic analysis of two recently developed deuterated structurally similar pyrazoloquinolinone compounds. DK-I-56-1 at concentrations below 1 mu M enhanced gamma-aminobutyric acid (GABA) currents at recombinant rat alpha 6 beta 3 gamma 2, alpha 6 beta 3 delta and alpha 6 beta 3 receptors, whereas it was inactive at most GABA(A) receptor subtypes containing other alpha subunits. DK-I-87-1 at concentrations below 1 mu M was inactive at alpha 6-containing receptors and only weakly modulated other GABA(A) receptors investigated. Both plasma and brain tissue kinetics of DK-I-56-1 were relatively slow, with half-lives of 6 and 13 hr, respectively, enabling the persistence of estimated free brain concentrations in the range 10-300 nM throughout a 24-hr period. Results obtained in two protocols of chronic constriction injury of the infraorbital nerve in rats dosed intraperitoneally with DK-I-56-1 during 14 days after surgery or with DK-I-56-1 or DK-I-87-1 during 14 days after trigeminal neuropathy were already established, demonstrated that DK-I-56-1 but not DK-I-87-1 significantly reduced the hypersensitivity response to von Frey filaments. Significance Neuropathic pain induced by trigeminal nerve damage is poorly controlled by current treatments. DK-I-56-1 that positively modulates alpha 6 GABA(A) receptors is appropriate for repeated administration and thus may represent a novel treatment option against the development and maintenance of trigeminal neuropathic pain.",
publisher = "Wiley, Hoboken",
journal = "European Journal of Pain",
title = "Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of alpha 6 GABA(A) receptors",
volume = "23",
number = "5",
pages = "973-984",
doi = "10.1002/ejp.1365"
}

Vasović, D., Divović, B., Treven, M., Knutson, D., Steudle, F., Scholze, P., Obradović, A., Fabjan, J., Brković, B., Sieghart, W., Ernst, M., Cook, J.,& Savić, M.. (2019). Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of alpha 6 GABA(A) receptors. in European Journal of Pain
Wiley, Hoboken., 23(5), 973-984.
https://doi.org/10.1002/ejp.1365

Vasović D, Divović B, Treven M, Knutson D, Steudle F, Scholze P, Obradović A, Fabjan J, Brković B, Sieghart W, Ernst M, Cook J, Savić M. Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of alpha 6 GABA(A) receptors. in European Journal of Pain. 2019;23(5):973-984.
doi:10.1002/ejp.1365 .

Vasović, Dina, Divović, Branka, Treven, Marco, Knutson, Daniel, Steudle, Friederike, Scholze, Petra, Obradović, Aleksandar, Fabjan, Jure, Brković, Božidar, Sieghart, Werner, Ernst, Margot, Cook, James, Savić, Miroslav, "Trigeminal neuropathic pain development and maintenance in rats are suppressed by a positive modulator of alpha 6 GABA(A) receptors" in European Journal of Pain, 23, no. 5 (2019):973-984,
https://doi.org/10.1002/ejp.1365 . .

TY  - JOUR
AU  - Ćetković, Dejan
AU  - Antić, Svetlana
AU  - Antonijević, Đorđe
AU  - Brković, Božidar
AU  - Đukić, Ksenija
AU  - Vujašković, Goran
AU  - Đurić, Marija
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2318
AB  - Background. The authors investigated morphologic parameters of the palatal cortex that affect the diffusion of local anesthetic solution in the region of the anterior middle superior alveolar (AMSA) nerve block injection site. Methods. The authors used computed tomographic (CT) and micro-CT imaging to assess 20 human skulls from an anatomic collection. Analysis of the C1 images included frequency, distribution, and width of the nutrient canals in the bony palate, according to to the person's sex and age. Micro-CT analysis involved measuring the thickness and porosity of palatal cortical bone in the area of the AMSA injection site in relation to the thickness and porosity of the opposite buccal cortical bone. Results. There was a statistically significant difference (P = .042) in the location of the nutrient canals between male specimens (> 50% in the border region) and female specimens (> 50% in the palatal process). Furthermore, the female skulls had significantly wider nutrient canal foramina (P = .042) than did the male skulls. Despite greater thickness, the palatal cortex in the area of the AMSA injection site had slightly greater porosity than did the buccal cortex. A significantly greater number of microcanals penetrated the whole cortical thickness in palatal than in buccal cortical bone (P = .001). Conclusions. The distribution and width of nutrient canals differed between male and female skulls. At the microscopic level, structural characteristics of the palatal cortex provide a good anatomic basis for the potential of a satisfactory AMSA injection success rate. Practical Implications. The AMSA technique success rate might be increased if the clinician adjusts the injection site to the distribution of nutrient canals, depending on the sex of the patient.
PB  - Amer Dental Assoc, Chicago
T2  - Journal of the American Dental Association
T1  - Nutrient canals and porosity of the bony palate A basis for the biological plausibility of the anterior middle superior alveolar nerve block
VL  - 149
IS  - 10
SP  - 859
EP  - 868
DO  - 10.1016/j.adaj.2018.05.015
ER  - 

@article{
author = "Ćetković, Dejan and Antić, Svetlana and Antonijević, Đorđe and Brković, Božidar and Đukić, Ksenija and Vujašković, Goran and Đurić, Marija",
year = "2018",
abstract = "Background. The authors investigated morphologic parameters of the palatal cortex that affect the diffusion of local anesthetic solution in the region of the anterior middle superior alveolar (AMSA) nerve block injection site. Methods. The authors used computed tomographic (CT) and micro-CT imaging to assess 20 human skulls from an anatomic collection. Analysis of the C1 images included frequency, distribution, and width of the nutrient canals in the bony palate, according to to the person's sex and age. Micro-CT analysis involved measuring the thickness and porosity of palatal cortical bone in the area of the AMSA injection site in relation to the thickness and porosity of the opposite buccal cortical bone. Results. There was a statistically significant difference (P = .042) in the location of the nutrient canals between male specimens (> 50% in the border region) and female specimens (> 50% in the palatal process). Furthermore, the female skulls had significantly wider nutrient canal foramina (P = .042) than did the male skulls. Despite greater thickness, the palatal cortex in the area of the AMSA injection site had slightly greater porosity than did the buccal cortex. A significantly greater number of microcanals penetrated the whole cortical thickness in palatal than in buccal cortical bone (P = .001). Conclusions. The distribution and width of nutrient canals differed between male and female skulls. At the microscopic level, structural characteristics of the palatal cortex provide a good anatomic basis for the potential of a satisfactory AMSA injection success rate. Practical Implications. The AMSA technique success rate might be increased if the clinician adjusts the injection site to the distribution of nutrient canals, depending on the sex of the patient.",
publisher = "Amer Dental Assoc, Chicago",
journal = "Journal of the American Dental Association",
title = "Nutrient canals and porosity of the bony palate A basis for the biological plausibility of the anterior middle superior alveolar nerve block",
volume = "149",
number = "10",
pages = "859-868",
doi = "10.1016/j.adaj.2018.05.015"
}

Ćetković, D., Antić, S., Antonijević, Đ., Brković, B., Đukić, K., Vujašković, G.,& Đurić, M.. (2018). Nutrient canals and porosity of the bony palate A basis for the biological plausibility of the anterior middle superior alveolar nerve block. in Journal of the American Dental Association
Amer Dental Assoc, Chicago., 149(10), 859-868.
https://doi.org/10.1016/j.adaj.2018.05.015

Ćetković D, Antić S, Antonijević Đ, Brković B, Đukić K, Vujašković G, Đurić M. Nutrient canals and porosity of the bony palate A basis for the biological plausibility of the anterior middle superior alveolar nerve block. in Journal of the American Dental Association. 2018;149(10):859-868.
doi:10.1016/j.adaj.2018.05.015 .

Ćetković, Dejan, Antić, Svetlana, Antonijević, Đorđe, Brković, Božidar, Đukić, Ksenija, Vujašković, Goran, Đurić, Marija, "Nutrient canals and porosity of the bony palate A basis for the biological plausibility of the anterior middle superior alveolar nerve block" in Journal of the American Dental Association, 149, no. 10 (2018):859-868,
https://doi.org/10.1016/j.adaj.2018.05.015 . .

TY  - JOUR
AU  - Milosavljević, A.
AU  - Đukić, Ljiljana
AU  - Toljić, Boško
AU  - Milašin, Jelena
AU  - Dželetović, Bojan
AU  - Brković, Božidar
AU  - Roganović, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2321
AB  - AimTo investigate melatonin (MEL) levels in human dental pulp tissue (hDP) in type 2 diabetic (T2D) participants and the underlying molecular mechanisms of its effects in human dental pulp cells (hDPCs) under hyperglycaemia. MethodologyThe study included 16 healthy and 16 T2D participants who underwent vital pulp extirpation for hDP and four healthy participants undergoing third molar extraction for hDPCs analyses. MTT and NRU were used as tests for cytotoxicity. The pulp tissue levels of MEL, inducible NO synthase (iNOS) and superoxide dismutase (SOD) activity, as well as iNOS, histone acetyltransferase p300 (p300) and SOD activity levels in hDPCs incubated with MEL (0.1 and 1.0mmolL(-1)) under normoglycaemia and hyperglycaemia were measured by enzyme-linked immunosorbent assay. Comparisons between the two groups were made by unpaired t-tests or Mann-Whitney test whilst the chi-square test was used for dichotomous variables. To compare more groups, the Kruskal-Wallis test with Dunn's multiple comparison was used, whilst Spearman correlation was used to assess association between two variables. ResultsMelatonin was decreased (124.3021.6 vs. 240.0 +/- 19.1 pgmL(-1), P lt 0.01), whilst iNOS levels increased (0.92 +/- 0.08 vs. 0.32 +/- 0.09ngmL(-1), P lt 0.01) in hDP from T2D compared to nondiabetic participants. In hDPCs, MEL (0.1 and 1.0mmolL(-1)) had no cytotoxicity. Incubation with 1.0mmolL(-1) of MEL (24h) decreased hyperglycaemia-induced increases of iNOS (0.34 +/- 0.01ngmL(-1) vs. 0.40 +/- 0.01ngmL(-1), P lt 0.01) and p300 (11.59 +/- 0.58ngmL(-1) vs. 16.12 +/- 0.39ngmL(-1), P lt 0.01), and also, increased SOD activity (87.11 +/- 3.10% vs. 68.56 +/- 3.77%, P lt 0.01) to the levels comparable to the normoglycaemic; iNOS and p300 protein expression levels showed strong positive correlation under hyperglycaemia (Spearman r=0.8242, P lt 0.001). ConclusionType 2 diabetic participants had decreased MEL in hDP. At pharmacological concentrations, MEL is not cytotoxic for hDPCs and normalizes iNOS and SOD activity levels in hyperglyceamic hDPCs suggesting its antioxidant and protective effects in human dental pulp tissue under hyperglycaemia.
PB  - Wiley, Hoboken
T2  - International Endodontic Journal
T1  - Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions
VL  - 51
IS  - 10
SP  - 1149
EP  - 1158
DO  - 10.1111/iej.12934
ER  - 

@article{
author = "Milosavljević, A. and Đukić, Ljiljana and Toljić, Boško and Milašin, Jelena and Dželetović, Bojan and Brković, Božidar and Roganović, Jelena",
year = "2018",
abstract = "AimTo investigate melatonin (MEL) levels in human dental pulp tissue (hDP) in type 2 diabetic (T2D) participants and the underlying molecular mechanisms of its effects in human dental pulp cells (hDPCs) under hyperglycaemia. MethodologyThe study included 16 healthy and 16 T2D participants who underwent vital pulp extirpation for hDP and four healthy participants undergoing third molar extraction for hDPCs analyses. MTT and NRU were used as tests for cytotoxicity. The pulp tissue levels of MEL, inducible NO synthase (iNOS) and superoxide dismutase (SOD) activity, as well as iNOS, histone acetyltransferase p300 (p300) and SOD activity levels in hDPCs incubated with MEL (0.1 and 1.0mmolL(-1)) under normoglycaemia and hyperglycaemia were measured by enzyme-linked immunosorbent assay. Comparisons between the two groups were made by unpaired t-tests or Mann-Whitney test whilst the chi-square test was used for dichotomous variables. To compare more groups, the Kruskal-Wallis test with Dunn's multiple comparison was used, whilst Spearman correlation was used to assess association between two variables. ResultsMelatonin was decreased (124.3021.6 vs. 240.0 +/- 19.1 pgmL(-1), P lt 0.01), whilst iNOS levels increased (0.92 +/- 0.08 vs. 0.32 +/- 0.09ngmL(-1), P lt 0.01) in hDP from T2D compared to nondiabetic participants. In hDPCs, MEL (0.1 and 1.0mmolL(-1)) had no cytotoxicity. Incubation with 1.0mmolL(-1) of MEL (24h) decreased hyperglycaemia-induced increases of iNOS (0.34 +/- 0.01ngmL(-1) vs. 0.40 +/- 0.01ngmL(-1), P lt 0.01) and p300 (11.59 +/- 0.58ngmL(-1) vs. 16.12 +/- 0.39ngmL(-1), P lt 0.01), and also, increased SOD activity (87.11 +/- 3.10% vs. 68.56 +/- 3.77%, P lt 0.01) to the levels comparable to the normoglycaemic; iNOS and p300 protein expression levels showed strong positive correlation under hyperglycaemia (Spearman r=0.8242, P lt 0.001). ConclusionType 2 diabetic participants had decreased MEL in hDP. At pharmacological concentrations, MEL is not cytotoxic for hDPCs and normalizes iNOS and SOD activity levels in hyperglyceamic hDPCs suggesting its antioxidant and protective effects in human dental pulp tissue under hyperglycaemia.",
publisher = "Wiley, Hoboken",
journal = "International Endodontic Journal",
title = "Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions",
volume = "51",
number = "10",
pages = "1149-1158",
doi = "10.1111/iej.12934"
}

Milosavljević, A., Đukić, L., Toljić, B., Milašin, J., Dželetović, B., Brković, B.,& Roganović, J.. (2018). Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions. in International Endodontic Journal
Wiley, Hoboken., 51(10), 1149-1158.
https://doi.org/10.1111/iej.12934

Milosavljević A, Đukić L, Toljić B, Milašin J, Dželetović B, Brković B, Roganović J. Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions. in International Endodontic Journal. 2018;51(10):1149-1158.
doi:10.1111/iej.12934 .

Milosavljević, A., Đukić, Ljiljana, Toljić, Boško, Milašin, Jelena, Dželetović, Bojan, Brković, Božidar, Roganović, Jelena, "Melatonin levels in human diabetic dental pulp tissue and its effects on dental pulp cells under hyperglycaemic conditions" in International Endodontic Journal, 51, no. 10 (2018):1149-1158,
https://doi.org/10.1111/iej.12934 . .

TY  - JOUR
AU  - Radović, Nikola
AU  - Nikolić-Jakoba, Nataša
AU  - Petrović, Nina
AU  - Milosavljević, Aleksandra
AU  - Brković, Božidar
AU  - Roganović, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2519
AB  - AimRecent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). Material and methodsmiR modulation was analysed using quantitative real-time PCR while SOD activity was measured spectrophotometrically. ResultsThe upregulation of miR-146a and miR-155 was observed in CP and CPDM patients' baseline, while the levels decreased after 6weeks of the non-surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR-146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR-146a and miR-155 were significantly associated with periodontitis when adjusting for age and gender. ConclusionsmiR-146a and miR-155 may be considered as possible novel biomarkers for periodontitis in non-diabetic and type 2 diabetic patients.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Periodontology
T1  - MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients
VL  - 45
IS  - 6
SP  - 663
EP  - 671
DO  - 10.1111/jcpe.12888
ER  - 

@article{
author = "Radović, Nikola and Nikolić-Jakoba, Nataša and Petrović, Nina and Milosavljević, Aleksandra and Brković, Božidar and Roganović, Jelena",
year = "2018",
abstract = "AimRecent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). Material and methodsmiR modulation was analysed using quantitative real-time PCR while SOD activity was measured spectrophotometrically. ResultsThe upregulation of miR-146a and miR-155 was observed in CP and CPDM patients' baseline, while the levels decreased after 6weeks of the non-surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR-146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR-146a and miR-155 were significantly associated with periodontitis when adjusting for age and gender. ConclusionsmiR-146a and miR-155 may be considered as possible novel biomarkers for periodontitis in non-diabetic and type 2 diabetic patients.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Periodontology",
title = "MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients",
volume = "45",
number = "6",
pages = "663-671",
doi = "10.1111/jcpe.12888"
}

Radović, N., Nikolić-Jakoba, N., Petrović, N., Milosavljević, A., Brković, B.,& Roganović, J.. (2018). MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. in Journal of Clinical Periodontology
Wiley, Hoboken., 45(6), 663-671.
https://doi.org/10.1111/jcpe.12888

Radović N, Nikolić-Jakoba N, Petrović N, Milosavljević A, Brković B, Roganović J. MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. in Journal of Clinical Periodontology. 2018;45(6):663-671.
doi:10.1111/jcpe.12888 .

Radović, Nikola, Nikolić-Jakoba, Nataša, Petrović, Nina, Milosavljević, Aleksandra, Brković, Božidar, Roganović, Jelena, "MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients" in Journal of Clinical Periodontology, 45, no. 6 (2018):663-671,
https://doi.org/10.1111/jcpe.12888 . .

TY  - JOUR
AU  - Radović, Nikola
AU  - Nikolić-Jakoba, Nataša
AU  - Petrović, Nina
AU  - Milosavljević, Aleksandra
AU  - Brković, Božidar
AU  - Roganović, Jelena
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2282
AB  - AimRecent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). Material and methodsmiR modulation was analysed using quantitative real-time PCR while SOD activity was measured spectrophotometrically. ResultsThe upregulation of miR-146a and miR-155 was observed in CP and CPDM patients' baseline, while the levels decreased after 6weeks of the non-surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR-146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR-146a and miR-155 were significantly associated with periodontitis when adjusting for age and gender. ConclusionsmiR-146a and miR-155 may be considered as possible novel biomarkers for periodontitis in non-diabetic and type 2 diabetic patients.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Periodontology
T1  - MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients
VL  - 45
IS  - 6
SP  - 663
EP  - 671
DO  - 10.1111/jcpe.12888
ER  - 

@article{
author = "Radović, Nikola and Nikolić-Jakoba, Nataša and Petrović, Nina and Milosavljević, Aleksandra and Brković, Božidar and Roganović, Jelena",
year = "2018",
abstract = "AimRecent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). Material and methodsmiR modulation was analysed using quantitative real-time PCR while SOD activity was measured spectrophotometrically. ResultsThe upregulation of miR-146a and miR-155 was observed in CP and CPDM patients' baseline, while the levels decreased after 6weeks of the non-surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR-146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR-146a and miR-155 were significantly associated with periodontitis when adjusting for age and gender. ConclusionsmiR-146a and miR-155 may be considered as possible novel biomarkers for periodontitis in non-diabetic and type 2 diabetic patients.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Periodontology",
title = "MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients",
volume = "45",
number = "6",
pages = "663-671",
doi = "10.1111/jcpe.12888"
}

Radović, N., Nikolić-Jakoba, N., Petrović, N., Milosavljević, A., Brković, B.,& Roganović, J.. (2018). MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. in Journal of Clinical Periodontology
Wiley, Hoboken., 45(6), 663-671.
https://doi.org/10.1111/jcpe.12888

Radović N, Nikolić-Jakoba N, Petrović N, Milosavljević A, Brković B, Roganović J. MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. in Journal of Clinical Periodontology. 2018;45(6):663-671.
doi:10.1111/jcpe.12888 .

Radović, Nikola, Nikolić-Jakoba, Nataša, Petrović, Nina, Milosavljević, Aleksandra, Brković, Božidar, Roganović, Jelena, "MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients" in Journal of Clinical Periodontology, 45, no. 6 (2018):663-671,
https://doi.org/10.1111/jcpe.12888 . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Antonijević, Đorđe
AU  - Poštić, Srđan
AU  - Ilić, Dragan
AU  - Vuković, Zorica
AU  - Milić, Marija
AU  - Fan, Yifang
AU  - Li, Zhiyu
AU  - Brković, Božidar
AU  - Durić, Marija
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2289
AB  - Introduction: The outcome of periapical surgery has been directly improved with the introduction of novel material formulations. The aim of the study was to compare the retrograde obturation quality of the following materials: calcium silicate (Biodentine; Septodont, Saint-Maur-des-Fosses, France), mineral trioxide aggregate (MTA+; Cerkamed Company, Stalowa Wola, Poland), and glass ionomer cement (Fuji IX; GC Corporation, Tokyo, Japan). Methods: Materials' wettability was calculated concerning the contact angles of the cements measured using a glycerol drop. Cements' porosity was determined using mercury intrusion porosimetry and micro computed tomographic (mu CT) imaging. Extracted upper human incisors were retrofilled, and mu CT analysis was applied to calculate the volume of the gap between the retrograde filling material and root canal dentin. Experiments were performed before and after soaking the materials in simulated body fluid (SBF). Results: No statistically significant differences were found among the contact angles of the studied materials after being soaked in SBF. The material with the lowest nanoporosity (Fuji IX: 2.99% and 4.17% before and after SBF, respectively) showed the highest values of microporosity (4.2% and 3.1% before and after SBF, respectively). Biodentine had the lowest value of microporosity (1.2% and 0.8% before and after SBF, respectively) and the lowest value of microgap to the root canal wall ([10 +/- 30] x 10(-3) mm(3)). Conclusions: Biodentine and MTA possess certain advantages over Fuji IX for hermetic obturation of retrograde root canals. Biodentine shows a tendency toward the lowest marginal gap at the cement-to-dentin interface.
PB  - Elsevier Science Inc, New York
T2  - Journal of Endodontics
T1  - Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin
VL  - 44
IS  - 5
SP  - 816
EP  - 821
DO  - 10.1016/j.joen.2017.09.022
ER  - 

@article{
author = "Biočanin, Vladimir and Antonijević, Đorđe and Poštić, Srđan and Ilić, Dragan and Vuković, Zorica and Milić, Marija and Fan, Yifang and Li, Zhiyu and Brković, Božidar and Durić, Marija",
year = "2018",
abstract = "Introduction: The outcome of periapical surgery has been directly improved with the introduction of novel material formulations. The aim of the study was to compare the retrograde obturation quality of the following materials: calcium silicate (Biodentine; Septodont, Saint-Maur-des-Fosses, France), mineral trioxide aggregate (MTA+; Cerkamed Company, Stalowa Wola, Poland), and glass ionomer cement (Fuji IX; GC Corporation, Tokyo, Japan). Methods: Materials' wettability was calculated concerning the contact angles of the cements measured using a glycerol drop. Cements' porosity was determined using mercury intrusion porosimetry and micro computed tomographic (mu CT) imaging. Extracted upper human incisors were retrofilled, and mu CT analysis was applied to calculate the volume of the gap between the retrograde filling material and root canal dentin. Experiments were performed before and after soaking the materials in simulated body fluid (SBF). Results: No statistically significant differences were found among the contact angles of the studied materials after being soaked in SBF. The material with the lowest nanoporosity (Fuji IX: 2.99% and 4.17% before and after SBF, respectively) showed the highest values of microporosity (4.2% and 3.1% before and after SBF, respectively). Biodentine had the lowest value of microporosity (1.2% and 0.8% before and after SBF, respectively) and the lowest value of microgap to the root canal wall ([10 +/- 30] x 10(-3) mm(3)). Conclusions: Biodentine and MTA possess certain advantages over Fuji IX for hermetic obturation of retrograde root canals. Biodentine shows a tendency toward the lowest marginal gap at the cement-to-dentin interface.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Endodontics",
title = "Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin",
volume = "44",
number = "5",
pages = "816-821",
doi = "10.1016/j.joen.2017.09.022"
}

Biočanin, V., Antonijević, Đ., Poštić, S., Ilić, D., Vuković, Z., Milić, M., Fan, Y., Li, Z., Brković, B.,& Durić, M.. (2018). Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin. in Journal of Endodontics
Elsevier Science Inc, New York., 44(5), 816-821.
https://doi.org/10.1016/j.joen.2017.09.022

Biočanin V, Antonijević Đ, Poštić S, Ilić D, Vuković Z, Milić M, Fan Y, Li Z, Brković B, Durić M. Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin. in Journal of Endodontics. 2018;44(5):816-821.
doi:10.1016/j.joen.2017.09.022 .

Biočanin, Vladimir, Antonijević, Đorđe, Poštić, Srđan, Ilić, Dragan, Vuković, Zorica, Milić, Marija, Fan, Yifang, Li, Zhiyu, Brković, Božidar, Durić, Marija, "Marginal Gaps between 2 Calcium Silicate and Glass lonomer Cements and Apical Root Dentin" in Journal of Endodontics, 44, no. 5 (2018):816-821,
https://doi.org/10.1016/j.joen.2017.09.022 . .

TY  - JOUR
AU  - Dimić, Aleksandar
AU  - Brković, Božidar
AU  - Erdoglija, Milan
AU  - Grgurević, Uglješa
AU  - Sotirović, Jelena
AU  - Rašić, Dejan
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2333
AB  - Introduction. Maxillary sinusistis of odontogenic origin is a wellknown condition that occurs due to close relationship of the maxillary posterior teeth to the maxillary sinus. We presented two patients with symptoms and signs of chronic inflammation of the maxillary sinus of odontogenic origin. Case report. In both patients, after clinical examination, microbiological testing, skin prick tests to inhalant allergens, and endoscopy of the nasal cavity, we performed the cone beam computed tomography (CBCT) of paranasal sinuses, which showed thickening of the mucosal lining of the maxillary sinus. The mucosal oedema resulted in obstruction of the osteomeatal complex in both patients. The presence of a foreign body in the right alveolar recess in the first case and in the left osteomeatal complex in the second case were noticed. The both foreign bodies had densities similar to bone. The alveolar recesses in both cases were below the level of the nasal cavity floor. The patients were treated by endoscopic approach, a combination of lower and middle meatal antrostomy. The thickened mucous membrane was removed in the region of the osteomeatal complex, and then the foreign bodies were removed in both cases. Histopathological analysis proved that both foreign bodies were tooth roots. Conclusion. This case report show how be able to successfully surgically remove foreign bodies from the maxillary sinuses using endoscopic approach, a combination of both, lower and middle meatal antrostomy.
AB  - Uvod. Maksilarni sinuzitis dentogenog porekla je dobro poznato stanje koje nastaje zbog blizine korenova gornjih zuba i maksilarnog sinusa. Prikazali smo dva bolesnika sa simptomima i znacima hroničnog zapaljenja maksilarnog sinusa dentogenog porekla. Prikaz bolesnika. Kod oba bolesnika, nakon kliničkog pregleda, mikrobioloških ispitivanja, kožnih proba sa inhalacionim alergenima, kao i endoskopije nosne šupljine, urađena je kompjuterizovana tomografija konusnog zraka - [cone beam computed tomography (CBCT)], koja je pokazala zadebljanje sluznice maksilarnog sinusa. Otok sluznice doveo je do opstrukcije ostiomeatalnog kompleksa. Uočeno je prisustvo stranog tela u desnom alveolarnom recesusu u prvom, i u predelu ostiomeatalnog kompleksa, u drugom slučaju. Oba strana tela davala su senku sličnu koštanoj supstanci. Dno alveolarnog recesusa sinusa je u oba slučaja bilo ispod ravni poda nosne šupljine. Bolesnici su operisani endoskopskim pristupom, kombinacijom srednje i donje antrostomije. Odstranjena je zadebljala sluznica u predelu ostiomeatalnog kompleksa, a nakon toga su uklonjena strana tela. Histopatološka analiza je u oba slučaja pokazala da su strana tela bili korenovi zuba. Zaključak. Ovim prikazom se ukazuje na mogućnost uspešnog hirurškog uklanjanja stranih tela iz maksilarnog sinusa endoskopskim pristupom, kombinacijom srednje i donje antrostomije.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Endoscopic antrostomy in the treatment of odontogenic maxillary sinusitis: Two cases report
T1  - Endoskopska antrostomija u lečenju dentogenog maksilarnog sinuzitisa
VL  - 75
IS  - 11
SP  - 1123
EP  - 1127
DO  - 10.2298/VSP160921011D
ER  - 

@article{
author = "Dimić, Aleksandar and Brković, Božidar and Erdoglija, Milan and Grgurević, Uglješa and Sotirović, Jelena and Rašić, Dejan",
year = "2018",
abstract = "Introduction. Maxillary sinusistis of odontogenic origin is a wellknown condition that occurs due to close relationship of the maxillary posterior teeth to the maxillary sinus. We presented two patients with symptoms and signs of chronic inflammation of the maxillary sinus of odontogenic origin. Case report. In both patients, after clinical examination, microbiological testing, skin prick tests to inhalant allergens, and endoscopy of the nasal cavity, we performed the cone beam computed tomography (CBCT) of paranasal sinuses, which showed thickening of the mucosal lining of the maxillary sinus. The mucosal oedema resulted in obstruction of the osteomeatal complex in both patients. The presence of a foreign body in the right alveolar recess in the first case and in the left osteomeatal complex in the second case were noticed. The both foreign bodies had densities similar to bone. The alveolar recesses in both cases were below the level of the nasal cavity floor. The patients were treated by endoscopic approach, a combination of lower and middle meatal antrostomy. The thickened mucous membrane was removed in the region of the osteomeatal complex, and then the foreign bodies were removed in both cases. Histopathological analysis proved that both foreign bodies were tooth roots. Conclusion. This case report show how be able to successfully surgically remove foreign bodies from the maxillary sinuses using endoscopic approach, a combination of both, lower and middle meatal antrostomy., Uvod. Maksilarni sinuzitis dentogenog porekla je dobro poznato stanje koje nastaje zbog blizine korenova gornjih zuba i maksilarnog sinusa. Prikazali smo dva bolesnika sa simptomima i znacima hroničnog zapaljenja maksilarnog sinusa dentogenog porekla. Prikaz bolesnika. Kod oba bolesnika, nakon kliničkog pregleda, mikrobioloških ispitivanja, kožnih proba sa inhalacionim alergenima, kao i endoskopije nosne šupljine, urađena je kompjuterizovana tomografija konusnog zraka - [cone beam computed tomography (CBCT)], koja je pokazala zadebljanje sluznice maksilarnog sinusa. Otok sluznice doveo je do opstrukcije ostiomeatalnog kompleksa. Uočeno je prisustvo stranog tela u desnom alveolarnom recesusu u prvom, i u predelu ostiomeatalnog kompleksa, u drugom slučaju. Oba strana tela davala su senku sličnu koštanoj supstanci. Dno alveolarnog recesusa sinusa je u oba slučaja bilo ispod ravni poda nosne šupljine. Bolesnici su operisani endoskopskim pristupom, kombinacijom srednje i donje antrostomije. Odstranjena je zadebljala sluznica u predelu ostiomeatalnog kompleksa, a nakon toga su uklonjena strana tela. Histopatološka analiza je u oba slučaja pokazala da su strana tela bili korenovi zuba. Zaključak. Ovim prikazom se ukazuje na mogućnost uspešnog hirurškog uklanjanja stranih tela iz maksilarnog sinusa endoskopskim pristupom, kombinacijom srednje i donje antrostomije.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Endoscopic antrostomy in the treatment of odontogenic maxillary sinusitis: Two cases report, Endoskopska antrostomija u lečenju dentogenog maksilarnog sinuzitisa",
volume = "75",
number = "11",
pages = "1123-1127",
doi = "10.2298/VSP160921011D"
}

Dimić, A., Brković, B., Erdoglija, M., Grgurević, U., Sotirović, J.,& Rašić, D.. (2018). Endoscopic antrostomy in the treatment of odontogenic maxillary sinusitis: Two cases report. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 75(11), 1123-1127.
https://doi.org/10.2298/VSP160921011D

Dimić A, Brković B, Erdoglija M, Grgurević U, Sotirović J, Rašić D. Endoscopic antrostomy in the treatment of odontogenic maxillary sinusitis: Two cases report. in Vojnosanitetski pregled. 2018;75(11):1123-1127.
doi:10.2298/VSP160921011D .

Dimić, Aleksandar, Brković, Božidar, Erdoglija, Milan, Grgurević, Uglješa, Sotirović, Jelena, Rašić, Dejan, "Endoscopic antrostomy in the treatment of odontogenic maxillary sinusitis: Two cases report" in Vojnosanitetski pregled, 75, no. 11 (2018):1123-1127,
https://doi.org/10.2298/VSP160921011D . .

TY  - CONF
AU  - Knutson, Daniel
AU  - Vasović, Dina
AU  - Divović, Branka
AU  - Treven, Marco
AU  - Steudle, Friederike
AU  - Scholze, Petra
AU  - Brković, Božidar
AU  - Sieghart, Werner
AU  - Ernst, Margot
AU  - Cook, James
AU  - Savić, Miroslav
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2316
PB  - Amer Chemical Soc, Washington
C3  - Abstracts of Papers of the American Chemical Society
T1  - Prevention of trigeminal neuropathic pain development in rats using novel deuterated GABAAR-alpha 6 subtype selective ligands
VL  - 256
UR  - https://hdl.handle.net/21.15107/rcub_smile_2316
ER  - 

@conference{
author = "Knutson, Daniel and Vasović, Dina and Divović, Branka and Treven, Marco and Steudle, Friederike and Scholze, Petra and Brković, Božidar and Sieghart, Werner and Ernst, Margot and Cook, James and Savić, Miroslav",
year = "2018",
publisher = "Amer Chemical Soc, Washington",
journal = "Abstracts of Papers of the American Chemical Society",
title = "Prevention of trigeminal neuropathic pain development in rats using novel deuterated GABAAR-alpha 6 subtype selective ligands",
volume = "256",
url = "https://hdl.handle.net/21.15107/rcub_smile_2316"
}

Knutson, D., Vasović, D., Divović, B., Treven, M., Steudle, F., Scholze, P., Brković, B., Sieghart, W., Ernst, M., Cook, J.,& Savić, M.. (2018). Prevention of trigeminal neuropathic pain development in rats using novel deuterated GABAAR-alpha 6 subtype selective ligands. in Abstracts of Papers of the American Chemical Society
Amer Chemical Soc, Washington., 256.
https://hdl.handle.net/21.15107/rcub_smile_2316

Knutson D, Vasović D, Divović B, Treven M, Steudle F, Scholze P, Brković B, Sieghart W, Ernst M, Cook J, Savić M. Prevention of trigeminal neuropathic pain development in rats using novel deuterated GABAAR-alpha 6 subtype selective ligands. in Abstracts of Papers of the American Chemical Society. 2018;256.
https://hdl.handle.net/21.15107/rcub_smile_2316 .

Knutson, Daniel, Vasović, Dina, Divović, Branka, Treven, Marco, Steudle, Friederike, Scholze, Petra, Brković, Božidar, Sieghart, Werner, Ernst, Margot, Cook, James, Savić, Miroslav, "Prevention of trigeminal neuropathic pain development in rats using novel deuterated GABAAR-alpha 6 subtype selective ligands" in Abstracts of Papers of the American Chemical Society, 256 (2018),
https://hdl.handle.net/21.15107/rcub_smile_2316 .

TY  - JOUR
AU  - Brković, Božidar
AU  - Andrić, Miroslav
AU  - Ćalasan, Dejan
AU  - Milić, Marija
AU  - Stepić, Jelena
AU  - Vučetić, Milan
AU  - Brajković, Denis
AU  - Todorović, Ljubomir
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2241
AB  - The purpose of this study was to investigate postoperative analgesic effect of ropivacaine administered as main or supplemental injection for the inferior alveolar nerve block (IANB) in patients undergoing lower third molar surgery. The double-blind randomized study comprised 72 healthy patients. All patients received two blocks, the IANB for surgical procedure + IANB after surgery for postoperative pain control, and were divided into three groups: (1) 2 % lidocaine/epinephrine + 1 % ropivacaine, (2) 2 % lidocaine/epinephrine + saline, and (3) 1 % ropivacaine + saline. The occurrence of postoperative pain, pain intensity and analgesic requirements were recorded. Data were statistically analyzed using chi-square, Fisher, and Kruskal-Wallis tests and analysis of variance (ANOVA) with Bonferroni and Tukey correction. Ropivacaine was more successful than lidocaine/epinephrine in obtaining duration of postoperative analgesia, reduction of pain, and analgesic requirements whether ropivacaine was used for surgical block or administered as a supplemental injection after surgery. Ropivacaine (1 %, 2 ml) resulted in effective postoperative analgesia after lower third molar surgery. Since pain control related to third molar surgery requires the effective surgical anesthesia and postoperative analgesia, the use of 1 % ropivacaine could be clinically relevant in a selection of appropriate pain control regimen for both surgical procedure and early postsurgical treatment.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study
VL  - 21
IS  - 3
SP  - 779
EP  - 785
DO  - 10.1007/s00784-016-1831-2
ER  - 

@article{
author = "Brković, Božidar and Andrić, Miroslav and Ćalasan, Dejan and Milić, Marija and Stepić, Jelena and Vučetić, Milan and Brajković, Denis and Todorović, Ljubomir",
year = "2017",
abstract = "The purpose of this study was to investigate postoperative analgesic effect of ropivacaine administered as main or supplemental injection for the inferior alveolar nerve block (IANB) in patients undergoing lower third molar surgery. The double-blind randomized study comprised 72 healthy patients. All patients received two blocks, the IANB for surgical procedure + IANB after surgery for postoperative pain control, and were divided into three groups: (1) 2 % lidocaine/epinephrine + 1 % ropivacaine, (2) 2 % lidocaine/epinephrine + saline, and (3) 1 % ropivacaine + saline. The occurrence of postoperative pain, pain intensity and analgesic requirements were recorded. Data were statistically analyzed using chi-square, Fisher, and Kruskal-Wallis tests and analysis of variance (ANOVA) with Bonferroni and Tukey correction. Ropivacaine was more successful than lidocaine/epinephrine in obtaining duration of postoperative analgesia, reduction of pain, and analgesic requirements whether ropivacaine was used for surgical block or administered as a supplemental injection after surgery. Ropivacaine (1 %, 2 ml) resulted in effective postoperative analgesia after lower third molar surgery. Since pain control related to third molar surgery requires the effective surgical anesthesia and postoperative analgesia, the use of 1 % ropivacaine could be clinically relevant in a selection of appropriate pain control regimen for both surgical procedure and early postsurgical treatment.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study",
volume = "21",
number = "3",
pages = "779-785",
doi = "10.1007/s00784-016-1831-2"
}

Brković, B., Andrić, M., Ćalasan, D., Milić, M., Stepić, J., Vučetić, M., Brajković, D.,& Todorović, L.. (2017). Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 21(3), 779-785.
https://doi.org/10.1007/s00784-016-1831-2

Brković B, Andrić M, Ćalasan D, Milić M, Stepić J, Vučetić M, Brajković D, Todorović L. Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study. in Clinical Oral Investigations. 2017;21(3):779-785.
doi:10.1007/s00784-016-1831-2 .

Brković, Božidar, Andrić, Miroslav, Ćalasan, Dejan, Milić, Marija, Stepić, Jelena, Vučetić, Milan, Brajković, Denis, Todorović, Ljubomir, "Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study" in Clinical Oral Investigations, 21, no. 3 (2017):779-785,
https://doi.org/10.1007/s00784-016-1831-2 . .

TY  - JOUR
AU  - Kosanić, Ivan
AU  - Andrić, Miroslav
AU  - Brković, Božidar
AU  - Koković, Vladimir
AU  - Jurišić, Milan
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2233
AB  - Background/Aim. The use of autogenous bone grafts for augmentation of the resorbed alveolar ridge is still considered the gold standard in implant dentistry. The aim of this study was to analyze the resorption rate of autogenous bone block grafts from the retromolar region placed in the frontal segment of the upper jaw unprotected by barrier membranes, to assess the stability of implants placed into the grafted bone, as well as to monitor its changes during the healing period. Methods. The study included 18 patients with a total of 20 grafted sites. The residual alveolar ridge was measured before and after the augmentation and prior to implant placement. All implants were restored with provisional crowns within 48 hours after the placement. Implant stability was assessed using resonance frequency analysis. Results. The average period from ridge augmentation to reentry was 5.4 months (range 4-6 months) . At reentry the healed alveolar ridge had a mean width of 6.1 ± 1.27 mm. The mean calculated width gain was 3.04 ± 1.22 mm. The overall surface resorption of block grafts was 0.68 ± 0.69 mm (18.85%). At the time of implant placement the mean value of implant stability quotient (ISQ) was 71.25 ± 5.77. The lowest ISQ values were noted after three weeks of healing, followed by a gradual increase until week 12. After 12 weeks implants showed significantly higher ISQ values compared to primary stability (p  lt  0.05 Wilcoxon signed ranks test). During the 3-years followup period no cases of implant loss were recorded. Conclusion. Despite a significant resorption of bone grafts, it was possible to place implants in all the cases and to use the immediate loading protocol without affecting implant survival rate.
AB  - Uvod/cilj. Primena autogenih koštanih graftova (implantata) za uvećavanje smanjenog (resorbovanog) alvelarnog grebena još uvek se smatra zlatnim standardom u implantologiji. Cilj ove studije bio je analiza stepena resorpcije autolognih koštanih blok transplantata nezaštićenih barijernim mebranama, uzetih iz retromolarnog predela mandibule i postavljenih u frontalni segment gornje vilice, procena stabilnosti implantata ugrađenih u povećanu regiju, kao i praćenje promene implantne stabilnosti tokom perioda oseointegracije. Metode. U studiju je bilo uključeno 18 pacijenata sa ukupno 20 autotransplantata. Širina rezidualnog alveolarnog grebena merena je pre i posle postavljanja transplantata, kao i neposredno pre ugradnje implantata. Svi implantati su opterećeni privremenim nadoknadama 48 sati nakon ugradnje. Stabilnost implantata procenjivana je primenom analize rezonantne frekvencije. Rezultati. Srednje vreme između uvećavanja grebena i ugradnje implantata iznosilo je 5,4 (4-6) meseci. Pre ugradnje implantata srednja vrednost širine grebena iznosila je 6,1 ± 1,27 mm, a povećanja širine grebena u odnosu na vrednosti pre uvećanja 3,04 ± 1,22 mm. Površinska resoprcija grafta iznosila je 18,85% (0,68 ± 0,69 mm). Srednja vrednost koeficijenta implantne stabilnosti (ISQ) u momentu ugradnje iznosila je 71,25 ± 5,77. Najniže vrednosti ISQ zabeležene su u trećoj nedelji nakon ugradnje, što je bilo praćeno postepenim porastom do dvanaeste nedelje zarastanja. Nakon dvanaest nedelja vrednosti ISQ bile su statitički značajno više od vrednosti u momentu ugradnje (p  lt  0,05 Wilcoxon test). Tokom trogodišnjeg perioda praćenja nije bilo izgubljenih implantata. Zaključak. Bez obzira na značajan stepen resorpcije autotransplantata, kod svih pacijenata bilo je moguće ugraditi implantate u uvećani greben, kao i primeniti protokol ranog opterećenja bez uticaja na stepen preživljavanja implantata.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes
T1  - Nezaštićeni koštani autotransplantati u prednjem segmentu gornje vilice - stepen resorpcije i klinički rezultati
VL  - 74
IS  - 4
SP  - 305
EP  - 310
DO  - 10.2298/VSP150429188K
ER  - 

@article{
author = "Kosanić, Ivan and Andrić, Miroslav and Brković, Božidar and Koković, Vladimir and Jurišić, Milan",
year = "2017",
abstract = "Background/Aim. The use of autogenous bone grafts for augmentation of the resorbed alveolar ridge is still considered the gold standard in implant dentistry. The aim of this study was to analyze the resorption rate of autogenous bone block grafts from the retromolar region placed in the frontal segment of the upper jaw unprotected by barrier membranes, to assess the stability of implants placed into the grafted bone, as well as to monitor its changes during the healing period. Methods. The study included 18 patients with a total of 20 grafted sites. The residual alveolar ridge was measured before and after the augmentation and prior to implant placement. All implants were restored with provisional crowns within 48 hours after the placement. Implant stability was assessed using resonance frequency analysis. Results. The average period from ridge augmentation to reentry was 5.4 months (range 4-6 months) . At reentry the healed alveolar ridge had a mean width of 6.1 ± 1.27 mm. The mean calculated width gain was 3.04 ± 1.22 mm. The overall surface resorption of block grafts was 0.68 ± 0.69 mm (18.85%). At the time of implant placement the mean value of implant stability quotient (ISQ) was 71.25 ± 5.77. The lowest ISQ values were noted after three weeks of healing, followed by a gradual increase until week 12. After 12 weeks implants showed significantly higher ISQ values compared to primary stability (p  lt  0.05 Wilcoxon signed ranks test). During the 3-years followup period no cases of implant loss were recorded. Conclusion. Despite a significant resorption of bone grafts, it was possible to place implants in all the cases and to use the immediate loading protocol without affecting implant survival rate., Uvod/cilj. Primena autogenih koštanih graftova (implantata) za uvećavanje smanjenog (resorbovanog) alvelarnog grebena još uvek se smatra zlatnim standardom u implantologiji. Cilj ove studije bio je analiza stepena resorpcije autolognih koštanih blok transplantata nezaštićenih barijernim mebranama, uzetih iz retromolarnog predela mandibule i postavljenih u frontalni segment gornje vilice, procena stabilnosti implantata ugrađenih u povećanu regiju, kao i praćenje promene implantne stabilnosti tokom perioda oseointegracije. Metode. U studiju je bilo uključeno 18 pacijenata sa ukupno 20 autotransplantata. Širina rezidualnog alveolarnog grebena merena je pre i posle postavljanja transplantata, kao i neposredno pre ugradnje implantata. Svi implantati su opterećeni privremenim nadoknadama 48 sati nakon ugradnje. Stabilnost implantata procenjivana je primenom analize rezonantne frekvencije. Rezultati. Srednje vreme između uvećavanja grebena i ugradnje implantata iznosilo je 5,4 (4-6) meseci. Pre ugradnje implantata srednja vrednost širine grebena iznosila je 6,1 ± 1,27 mm, a povećanja širine grebena u odnosu na vrednosti pre uvećanja 3,04 ± 1,22 mm. Površinska resoprcija grafta iznosila je 18,85% (0,68 ± 0,69 mm). Srednja vrednost koeficijenta implantne stabilnosti (ISQ) u momentu ugradnje iznosila je 71,25 ± 5,77. Najniže vrednosti ISQ zabeležene su u trećoj nedelji nakon ugradnje, što je bilo praćeno postepenim porastom do dvanaeste nedelje zarastanja. Nakon dvanaest nedelja vrednosti ISQ bile su statitički značajno više od vrednosti u momentu ugradnje (p  lt  0,05 Wilcoxon test). Tokom trogodišnjeg perioda praćenja nije bilo izgubljenih implantata. Zaključak. Bez obzira na značajan stepen resorpcije autotransplantata, kod svih pacijenata bilo je moguće ugraditi implantate u uvećani greben, kao i primeniti protokol ranog opterećenja bez uticaja na stepen preživljavanja implantata.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes, Nezaštićeni koštani autotransplantati u prednjem segmentu gornje vilice - stepen resorpcije i klinički rezultati",
volume = "74",
number = "4",
pages = "305-310",
doi = "10.2298/VSP150429188K"
}

Kosanić, I., Andrić, M., Brković, B., Koković, V.,& Jurišić, M.. (2017). Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(4), 305-310.
https://doi.org/10.2298/VSP150429188K

Kosanić I, Andrić M, Brković B, Koković V, Jurišić M. Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes. in Vojnosanitetski pregled. 2017;74(4):305-310.
doi:10.2298/VSP150429188K .

Kosanić, Ivan, Andrić, Miroslav, Brković, Božidar, Koković, Vladimir, Jurišić, Milan, "Unprotected autogenous bone block grafts in the anterior maxilla: Resorption rates and clinical outcomes" in Vojnosanitetski pregled, 74, no. 4 (2017):305-310,
https://doi.org/10.2298/VSP150429188K . .

TY  - JOUR
AU  - Marjanović, Uroš
AU  - Jurišić, Milan
AU  - Brković, Božidar
AU  - Jakovljević, Aleksandar
AU  - Miličić, Biljana
AU  - Marjanović, Marjan
AU  - Ivanović, Julija
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2255
AB  - Background/Aim. Local infiltration anaesthesia (LIA) is significantly simpler compared to the inferior alveolar nerve block (IAB) and less unpleasant for patients. However, it is not efficient if used in posterior region of the mandible, at least with traditional local anaesthetics. The aim of this study was to compare anaesthetic efficacy of two techniques the LIA in the posterior segment of the mandible, and the IAB, using 4% articaine with 1 : 100,000 adrenaline and to note possible changes in haemodynamic parameters caused by these two techniques. Methods. Sixty pre-informed patients were divided into two study groups. Both groups received 1.8 mL of the same anaesthetic solution, 4% articaine with adrenaline 1 : 100,000, with two different techniques of local anaesthesia. The first group received the LIA in projection of root apex of the first lower molar; the second group received the IAB. The examined parameters were: changes in tooth sensitivity after 5 and 30 minutes in relation to the value recorded before administering the anaesthetics, onset of anaesthesia, width of anaesthetic field, and duration of anaesthesia. Also, the impact of the applied techniques on cardiovascular parameters was noticed. Results. The LIA group had a statistically significant decrease in sensitivity 5 minutes after application of the local anaesthetic. The decreasing trend continued between 5 and 30 minutes, although without statistical significance. There was no statistically significant difference in sensitivity changes between two groups for the first molar and the first and second premolars. However, there was a statistically significant difference in duration of local anaesthesia in favour of the IAB, while the width of anaesthetic fields was significantly higher after the LIA. Significant changes in hemodynamic parameters were not recorded within the two groups. Conclusion. The effect of the LIA on tooth sensitivity of premolars and first molar is quite satisfactory. The IAB was more effective for canine and second molar. None of the tested techniques had any significant effect on the cardiovascular parameters.
AB  - Uvod/Cilj. Lokalna infiltraciona anestezija (LIA) mnogo je jednostavnija u poređenju sa mandibularnom alveolarnom blok anestezijom (MA), a i prijatnija je za pacijente. Međutim, ona nije efikasna ukoliko se daje u posteriorni deo mandibule korišćenjem tradicionalnih lokalnih anestetika. Cilj istraživanja bio je da se uporedi efikasnost dve tehnike anestezije, LIA u bočnom segmentu mandibule, i mandibularne anestezije primenom 4% artikaina sa 1 : 100 000 adrenalina, i uoče eventualne promene hemodinamskih parametara koje ove tehnike mogu da prouzrokuju. Metode. Šezdeset prethodno informisanih pacijenata bilo je podeljeno u dve studijske grupe. Obe grupe su dobile 1,8 mL istog anestetika, 4% artikain sa adrenalinom 1 : 100 000, primenom dve tehnike anestezije. Prva grupa ispitanika primila je lokalnu infiltracionu anesteziju u projekciji vrhova korenova prvog donjeg molara. Druga grupa ispitanika primila je mandibularnu anesteziju. Ispitivani parametri bili su: promene u osetljivosti zuba nakon pet i 30 minuta u odnosu na vrednosti zabeležene pre davanja anestetika, početak dejstva anestezije, širina anestetičkog polja i trajanje anestezije. Takođe, zabeležen je i uticaj primenjenih tehnika na kardiovaskularne parametre. Rezultati. Grupa ispitanika LIA imala je statistički značajno smanjenje osetljivosti zuba pet minuta nakon primene LIA. Trend smanjenja postojao je i dalje, između pet i 30 minuta, iako bez statističke značajnosti. Nije bilo statistički značajne razlike u promenama osetljivosti između dve grupe na prvom molaru i prvom i drugom premolaru. Postojala je statistički značajna razlika u trajanju anestezije u korist MA, dok je širina anestetičkog polja bila značajno veća u LIA grupi. Klinički značajne promene hemodinamskih parametara nisu zabeležene ni u jednoj studijskoj grupi. Zaključak. Učinak LIA bio je zadovoljavajući kada su u pitanju premolari i prvi molar. Za anesteziju očnjaka i drugog molara uspešnija je bila MA. Nijedna od ispitivanih tehnika nije imala značajan uticaj na kardiovaskularne parametare.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Comparative clinical evaluation of two different techniques of local anaesthesia in the posterior mandible using 4% articaine with 1:100,000 adrenaline
T1  - Uporedna klinička procena dve tehnike lokalne anestezije u bočnom segmentu mandibule primenom 4% artikaina sa 1:100.000 adrenalinom
VL  - 74
IS  - 11
SP  - 1030
EP  - 1035
DO  - 10.2298/VSP160118200M
ER  - 

@article{
author = "Marjanović, Uroš and Jurišić, Milan and Brković, Božidar and Jakovljević, Aleksandar and Miličić, Biljana and Marjanović, Marjan and Ivanović, Julija",
year = "2017",
abstract = "Background/Aim. Local infiltration anaesthesia (LIA) is significantly simpler compared to the inferior alveolar nerve block (IAB) and less unpleasant for patients. However, it is not efficient if used in posterior region of the mandible, at least with traditional local anaesthetics. The aim of this study was to compare anaesthetic efficacy of two techniques the LIA in the posterior segment of the mandible, and the IAB, using 4% articaine with 1 : 100,000 adrenaline and to note possible changes in haemodynamic parameters caused by these two techniques. Methods. Sixty pre-informed patients were divided into two study groups. Both groups received 1.8 mL of the same anaesthetic solution, 4% articaine with adrenaline 1 : 100,000, with two different techniques of local anaesthesia. The first group received the LIA in projection of root apex of the first lower molar; the second group received the IAB. The examined parameters were: changes in tooth sensitivity after 5 and 30 minutes in relation to the value recorded before administering the anaesthetics, onset of anaesthesia, width of anaesthetic field, and duration of anaesthesia. Also, the impact of the applied techniques on cardiovascular parameters was noticed. Results. The LIA group had a statistically significant decrease in sensitivity 5 minutes after application of the local anaesthetic. The decreasing trend continued between 5 and 30 minutes, although without statistical significance. There was no statistically significant difference in sensitivity changes between two groups for the first molar and the first and second premolars. However, there was a statistically significant difference in duration of local anaesthesia in favour of the IAB, while the width of anaesthetic fields was significantly higher after the LIA. Significant changes in hemodynamic parameters were not recorded within the two groups. Conclusion. The effect of the LIA on tooth sensitivity of premolars and first molar is quite satisfactory. The IAB was more effective for canine and second molar. None of the tested techniques had any significant effect on the cardiovascular parameters., Uvod/Cilj. Lokalna infiltraciona anestezija (LIA) mnogo je jednostavnija u poređenju sa mandibularnom alveolarnom blok anestezijom (MA), a i prijatnija je za pacijente. Međutim, ona nije efikasna ukoliko se daje u posteriorni deo mandibule korišćenjem tradicionalnih lokalnih anestetika. Cilj istraživanja bio je da se uporedi efikasnost dve tehnike anestezije, LIA u bočnom segmentu mandibule, i mandibularne anestezije primenom 4% artikaina sa 1 : 100 000 adrenalina, i uoče eventualne promene hemodinamskih parametara koje ove tehnike mogu da prouzrokuju. Metode. Šezdeset prethodno informisanih pacijenata bilo je podeljeno u dve studijske grupe. Obe grupe su dobile 1,8 mL istog anestetika, 4% artikain sa adrenalinom 1 : 100 000, primenom dve tehnike anestezije. Prva grupa ispitanika primila je lokalnu infiltracionu anesteziju u projekciji vrhova korenova prvog donjeg molara. Druga grupa ispitanika primila je mandibularnu anesteziju. Ispitivani parametri bili su: promene u osetljivosti zuba nakon pet i 30 minuta u odnosu na vrednosti zabeležene pre davanja anestetika, početak dejstva anestezije, širina anestetičkog polja i trajanje anestezije. Takođe, zabeležen je i uticaj primenjenih tehnika na kardiovaskularne parametre. Rezultati. Grupa ispitanika LIA imala je statistički značajno smanjenje osetljivosti zuba pet minuta nakon primene LIA. Trend smanjenja postojao je i dalje, između pet i 30 minuta, iako bez statističke značajnosti. Nije bilo statistički značajne razlike u promenama osetljivosti između dve grupe na prvom molaru i prvom i drugom premolaru. Postojala je statistički značajna razlika u trajanju anestezije u korist MA, dok je širina anestetičkog polja bila značajno veća u LIA grupi. Klinički značajne promene hemodinamskih parametara nisu zabeležene ni u jednoj studijskoj grupi. Zaključak. Učinak LIA bio je zadovoljavajući kada su u pitanju premolari i prvi molar. Za anesteziju očnjaka i drugog molara uspešnija je bila MA. Nijedna od ispitivanih tehnika nije imala značajan uticaj na kardiovaskularne parametare.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Comparative clinical evaluation of two different techniques of local anaesthesia in the posterior mandible using 4% articaine with 1:100,000 adrenaline, Uporedna klinička procena dve tehnike lokalne anestezije u bočnom segmentu mandibule primenom 4% artikaina sa 1:100.000 adrenalinom",
volume = "74",
number = "11",
pages = "1030-1035",
doi = "10.2298/VSP160118200M"
}

Marjanović, U., Jurišić, M., Brković, B., Jakovljević, A., Miličić, B., Marjanović, M.,& Ivanović, J.. (2017). Comparative clinical evaluation of two different techniques of local anaesthesia in the posterior mandible using 4% articaine with 1:100,000 adrenaline. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(11), 1030-1035.
https://doi.org/10.2298/VSP160118200M

Marjanović U, Jurišić M, Brković B, Jakovljević A, Miličić B, Marjanović M, Ivanović J. Comparative clinical evaluation of two different techniques of local anaesthesia in the posterior mandible using 4% articaine with 1:100,000 adrenaline. in Vojnosanitetski pregled. 2017;74(11):1030-1035.
doi:10.2298/VSP160118200M .

Marjanović, Uroš, Jurišić, Milan, Brković, Božidar, Jakovljević, Aleksandar, Miličić, Biljana, Marjanović, Marjan, Ivanović, Julija, "Comparative clinical evaluation of two different techniques of local anaesthesia in the posterior mandible using 4% articaine with 1:100,000 adrenaline" in Vojnosanitetski pregled, 74, no. 11 (2017):1030-1035,
https://doi.org/10.2298/VSP160118200M . .

TY  - JOUR
AU  - Baćević, Miljana
AU  - Brković, Božidar
AU  - Albert, Adelin
AU  - Rompen, Eric
AU  - Radermecker, Regis P.
AU  - Lambert, France
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2213
AB  - Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration.
PB  - Springer, New York
T2  - Calcified Tissue International
T1  - Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review
VL  - 101
IS  - 6
SP  - 553
EP  - 563
DO  - 10.1007/s00223-017-0327-7
ER  - 

@article{
author = "Baćević, Miljana and Brković, Božidar and Albert, Adelin and Rompen, Eric and Radermecker, Regis P. and Lambert, France",
year = "2017",
abstract = "Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration.",
publisher = "Springer, New York",
journal = "Calcified Tissue International",
title = "Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review",
volume = "101",
number = "6",
pages = "553-563",
doi = "10.1007/s00223-017-0327-7"
}

Baćević, M., Brković, B., Albert, A., Rompen, E., Radermecker, R. P.,& Lambert, F.. (2017). Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review. in Calcified Tissue International
Springer, New York., 101(6), 553-563.
https://doi.org/10.1007/s00223-017-0327-7

Baćević M, Brković B, Albert A, Rompen E, Radermecker RP, Lambert F. Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review. in Calcified Tissue International. 2017;101(6):553-563.
doi:10.1007/s00223-017-0327-7 .

Baćević, Miljana, Brković, Božidar, Albert, Adelin, Rompen, Eric, Radermecker, Regis P., Lambert, France, "Does Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review" in Calcified Tissue International, 101, no. 6 (2017):553-563,
https://doi.org/10.1007/s00223-017-0327-7 . .

TY  - JOUR
AU  - Milić, Marija
AU  - Brković, Božidar
AU  - Kršljak, Elena
AU  - Stojić, Dragica
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2179
AB  - The pulpal anesthetic and cardiovascular parameters obtained by 2 % lidocaine with epinephrine (LE; 1:80,000) or clonidine (LC; 15 mcg/ml) were studied in diabetes mellitus (DM) type 2 and healthy volunteers (72), after maxillary infiltration anesthesia. Onset and duration of pulpal anesthesia were measured by electric pulp tester; vasoconstrictive effect of used local anesthetic mixtures by laser Doppler flowmetry (LDF) through pulpal blood flow (PBF); systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were registered by electrocardiogram monitoring. Onset of pulpal anesthesia was shorter for LC than for LE in healthy, while it was not different in diabetic participants; duration of pulpal anesthesia was significantly longer in type 2 diabetic participants, regardless of used anesthetic mixture. Significant reduction of PBF with LE was observed during 45 min in healthy and 60 min in diabetic participants, while with LC such reduction was observed during 45 min in both groups. LE caused a significant increase of SBP in the 5th and 15th minutes in diabetic versus healthy participants, while LC decreased SBP from the 10th to 60th minutes in healthy versus diabetic participants. DM type 2 influences duration of maxillary infiltration anesthesia obtained with LE and LC, and systolic blood pressure during LE anesthesia. The obtained results provide elements for future protocols concerning intraoral local anesthesia in DM type 2 patients.
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers
VL  - 20
IS  - 6
SP  - 1283
EP  - 1293
DO  - 10.1007/s00784-015-1610-5
ER  - 

@article{
author = "Milić, Marija and Brković, Božidar and Kršljak, Elena and Stojić, Dragica",
year = "2016",
abstract = "The pulpal anesthetic and cardiovascular parameters obtained by 2 % lidocaine with epinephrine (LE; 1:80,000) or clonidine (LC; 15 mcg/ml) were studied in diabetes mellitus (DM) type 2 and healthy volunteers (72), after maxillary infiltration anesthesia. Onset and duration of pulpal anesthesia were measured by electric pulp tester; vasoconstrictive effect of used local anesthetic mixtures by laser Doppler flowmetry (LDF) through pulpal blood flow (PBF); systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were registered by electrocardiogram monitoring. Onset of pulpal anesthesia was shorter for LC than for LE in healthy, while it was not different in diabetic participants; duration of pulpal anesthesia was significantly longer in type 2 diabetic participants, regardless of used anesthetic mixture. Significant reduction of PBF with LE was observed during 45 min in healthy and 60 min in diabetic participants, while with LC such reduction was observed during 45 min in both groups. LE caused a significant increase of SBP in the 5th and 15th minutes in diabetic versus healthy participants, while LC decreased SBP from the 10th to 60th minutes in healthy versus diabetic participants. DM type 2 influences duration of maxillary infiltration anesthesia obtained with LE and LC, and systolic blood pressure during LE anesthesia. The obtained results provide elements for future protocols concerning intraoral local anesthesia in DM type 2 patients.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers",
volume = "20",
number = "6",
pages = "1283-1293",
doi = "10.1007/s00784-015-1610-5"
}

Milić, M., Brković, B., Kršljak, E.,& Stojić, D.. (2016). Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers. in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 20(6), 1283-1293.
https://doi.org/10.1007/s00784-015-1610-5

Milić M, Brković B, Kršljak E, Stojić D. Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers. in Clinical Oral Investigations. 2016;20(6):1283-1293.
doi:10.1007/s00784-015-1610-5 .

Milić, Marija, Brković, Božidar, Kršljak, Elena, Stojić, Dragica, "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers" in Clinical Oral Investigations, 20, no. 6 (2016):1283-1293,
https://doi.org/10.1007/s00784-015-1610-5 . .

TY  - JOUR
AU  - Milić, Marija
AU  - Brković, Božidar
AU  - Kršljak, Elena
AU  - Stojić, Dragica
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2149
PB  - Springer Heidelberg, Heidelberg
T2  - Clinical Oral Investigations
T1  - Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016)
VL  - 20
IS  - 6
SP  - 1295
EP  - 1296
DO  - 10.1007/s00784-015-1628-8
ER  - 

@article{
author = "Milić, Marija and Brković, Božidar and Kršljak, Elena and Stojić, Dragica",
year = "2016",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Clinical Oral Investigations",
title = "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016)",
volume = "20",
number = "6",
pages = "1295-1296",
doi = "10.1007/s00784-015-1628-8"
}

Milić, M., Brković, B., Kršljak, E.,& Stojić, D.. (2016). Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016). in Clinical Oral Investigations
Springer Heidelberg, Heidelberg., 20(6), 1295-1296.
https://doi.org/10.1007/s00784-015-1628-8

Milić M, Brković B, Kršljak E, Stojić D. Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016). in Clinical Oral Investigations. 2016;20(6):1295-1296.
doi:10.1007/s00784-015-1628-8 .

Milić, Marija, Brković, Božidar, Kršljak, Elena, Stojić, Dragica, "Comparison of pulpal anesthesia and cardiovascular parameters with lidocaine with epinephrine and lidocaine with clonidine after maxillary infiltration in type 2 diabetic volunteers (vol 20, pg 1283, 2016)" in Clinical Oral Investigations, 20, no. 6 (2016):1295-1296,
https://doi.org/10.1007/s00784-015-1628-8 . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Milić, Marija
AU  - Vučetić, Milan
AU  - Baćević, Miljana
AU  - Vasović, Dina
AU  - Živadinović, Milka
AU  - Ćetković, Dejan
AU  - Ćalasan, Dejan
AU  - Brković, Božidar
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2073
AB  - Introduction. The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Case report. We presented apical healing of the upper central incisor, retrofilled with TSC, in a diabetic patient (type 2 DM) with peripheral neuropathy. Standard root-end resection of upper central incisor was accompanied by retropreparation using ultrasonic retrotips to the depth of 3 mm and retrofilling with TSC. Postoperatively, the surgical wound healed uneventfully. However, the patient reported undefined dull pain in the operated area that could possibly be attributed to undiagnosed intraoral diabetic peripheral neuropathy, what was evaluated clinically. Conclusion. Although TSC presents a suitable material for apical root-end filling in the treatment of chronic periradicular lesions a possible presence of systemic diseases, like type 2 DM, has to be considered in the treatment outcome estimation.
AB  - Uvod. Materijal koji se koristi za retrogradnu opturaciju kanala korena trebalo bi da bude biokompatibilan sa okolnim periapeksnim tkivom i da stimuliše procese njegove regeneracije. Trikalcijum silikatni cement (TSC), kao novi dentalni materijal, pokazuje dobro zaptivanje, visoku kompresivnu snagu i bolju ivičnu adaptaciju u odnosu na standardno korišćene materijale za retroopturaciju. Iako postoperativno zarastanje periapikalnog tkiva najviše zavisi od karakteristika materijala za retroopturaciju, ponekad na uspeh zarastanja može uticati i prisustvo neke sistemske bolesti kao što je dijabetes melitus (DM). Prikaz bolesnika. Prikazali smo apikalno zarastanje u predelu gornjeg centralnog sekutića, nakon retroopturacije sa TSC, kod bolesnika sa DM tipa 2 i prisutnom perifernom neuropatijom. Standardna resekcija korena gornjeg centralnog sekutića bila je urađena retropreparacijom ultrazvučnim nastavcima do dubine od 3 mm i retrogradnom opturacijom sa TSC. Zarastanje postoperativne regije bilo je u fiziološkim granicama. Bolesnik se, međutim, žalio na nedefinisan, tup bol u predelu operisane regije koji je verovatno bio povezan sa nedijagnostikovanom intraoralnom dijabetičnom perifernom neuropatijom, što je potvrđeno kliničkim nalazom. Zaključak. Iako TSC predstavlja pogodan materijal za retrogradnu opturaciju kanala korena zuba u lečenju hroničnih periradikularnih lezija, u proceni ishoda lečenja treba imati u vidu i moguće prisustvo perifernih manfestacija sistemskih bolesti kao što je DM tipa 2.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report
T1  - Punjenje kanala korena cementom na bazi trikalcijum-silikata kod bolesnika sa dijabetesom melitusom
VL  - 73
IS  - 12
SP  - 1173
EP  - 1177
DO  - 10.2298/VSP150606137B
ER  - 

@article{
author = "Biočanin, Vladimir and Milić, Marija and Vučetić, Milan and Baćević, Miljana and Vasović, Dina and Živadinović, Milka and Ćetković, Dejan and Ćalasan, Dejan and Brković, Božidar",
year = "2016",
abstract = "Introduction. The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Case report. We presented apical healing of the upper central incisor, retrofilled with TSC, in a diabetic patient (type 2 DM) with peripheral neuropathy. Standard root-end resection of upper central incisor was accompanied by retropreparation using ultrasonic retrotips to the depth of 3 mm and retrofilling with TSC. Postoperatively, the surgical wound healed uneventfully. However, the patient reported undefined dull pain in the operated area that could possibly be attributed to undiagnosed intraoral diabetic peripheral neuropathy, what was evaluated clinically. Conclusion. Although TSC presents a suitable material for apical root-end filling in the treatment of chronic periradicular lesions a possible presence of systemic diseases, like type 2 DM, has to be considered in the treatment outcome estimation., Uvod. Materijal koji se koristi za retrogradnu opturaciju kanala korena trebalo bi da bude biokompatibilan sa okolnim periapeksnim tkivom i da stimuliše procese njegove regeneracije. Trikalcijum silikatni cement (TSC), kao novi dentalni materijal, pokazuje dobro zaptivanje, visoku kompresivnu snagu i bolju ivičnu adaptaciju u odnosu na standardno korišćene materijale za retroopturaciju. Iako postoperativno zarastanje periapikalnog tkiva najviše zavisi od karakteristika materijala za retroopturaciju, ponekad na uspeh zarastanja može uticati i prisustvo neke sistemske bolesti kao što je dijabetes melitus (DM). Prikaz bolesnika. Prikazali smo apikalno zarastanje u predelu gornjeg centralnog sekutića, nakon retroopturacije sa TSC, kod bolesnika sa DM tipa 2 i prisutnom perifernom neuropatijom. Standardna resekcija korena gornjeg centralnog sekutića bila je urađena retropreparacijom ultrazvučnim nastavcima do dubine od 3 mm i retrogradnom opturacijom sa TSC. Zarastanje postoperativne regije bilo je u fiziološkim granicama. Bolesnik se, međutim, žalio na nedefinisan, tup bol u predelu operisane regije koji je verovatno bio povezan sa nedijagnostikovanom intraoralnom dijabetičnom perifernom neuropatijom, što je potvrđeno kliničkim nalazom. Zaključak. Iako TSC predstavlja pogodan materijal za retrogradnu opturaciju kanala korena zuba u lečenju hroničnih periradikularnih lezija, u proceni ishoda lečenja treba imati u vidu i moguće prisustvo perifernih manfestacija sistemskih bolesti kao što je DM tipa 2.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report, Punjenje kanala korena cementom na bazi trikalcijum-silikata kod bolesnika sa dijabetesom melitusom",
volume = "73",
number = "12",
pages = "1173-1177",
doi = "10.2298/VSP150606137B"
}

Biočanin, V., Milić, M., Vučetić, M., Baćević, M., Vasović, D., Živadinović, M., Ćetković, D., Ćalasan, D.,& Brković, B.. (2016). Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(12), 1173-1177.
https://doi.org/10.2298/VSP150606137B

Biočanin V, Milić M, Vučetić M, Baćević M, Vasović D, Živadinović M, Ćetković D, Ćalasan D, Brković B. Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report. in Vojnosanitetski pregled. 2016;73(12):1173-1177.
doi:10.2298/VSP150606137B .

Biočanin, Vladimir, Milić, Marija, Vučetić, Milan, Baćević, Miljana, Vasović, Dina, Živadinović, Milka, Ćetković, Dejan, Ćalasan, Dejan, Brković, Božidar, "Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report" in Vojnosanitetski pregled, 73, no. 12 (2016):1173-1177,
https://doi.org/10.2298/VSP150606137B . .

TY  - JOUR
AU  - Živadinović, Milka
AU  - Andrić, Miroslav
AU  - Milošević, Verica
AU  - Manojlović-Stojanoski, Milica
AU  - Prokić, Branislav
AU  - Prokić, Bogomir
AU  - Dimić, Aleksandar
AU  - Ćalasan, Dejan
AU  - Brković, Božidar
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2082
AB  - Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as unfilled controls (n = 4). After 4 weeks of healing, animals were sacrificed and calvarial bone blocks were taken for histologic and histomorphometric analysis. Beside descriptive histologic evaluation, the percentage of new bone formation, connective tissue and residual graft were calculated. All parameters were statistically evaluated by Friedman Test and post hock Wilcoxon Singed Ranks Test with a significance of p  lt  0.05. Results. Histology revealed active new bone formation peripherally with centrally located connective tissue, newly formed woven bone and well incorporated residual grafts in all treated defects. Control samples showed no bone bridging of defects. There was a significantly more new bone in autogeonous graft (53%) compared with β-tricalcium phosphate (30%), (p  lt  0.030) and control (7%), (p  lt  0.000) groups. A significant difference was also recorded between β-tricalcium phosphate and control groups (p  lt  0.008). Conclusion. In the present study on the rabbit grafting model with induced diabetes mellitus type I, the effective bone regeneration of critical bone defects was obtained using autogenous bone graft.
AB  - Uvod/Cilj. Mehanizam otežanog zarastanja tkiva kod dijabetesa melitusa zasnovan je na različitim promenama funkcije na tkivnom i ćelijskom nivou, usled prisutnih mikro- i makrovaskularnih promena. Kao hronično metaboličko oboljenje sa vaskularnim komplikacijama, dijabetes melitus zahvata i proces koštane regeneracije. Terapijski postupci u okviru regeneracije kosti obuhvataju primenu autotransplantata sa oseoinduktivnim delovanjem i sintetskih osteokonduktivnih materijala, kao što je i β-trikalcijum fosfat. Cilj ovog rada bio je da se ispita kvantitet i kvalitet novoformiranog koštanog tkiva posle korišćenja autotransplantata kosti i β-trikalcijum fosfata, na modelu kritičnog defekta kalvarije kunića sa eksperimentalno izazvanim dijabetesom melitusom tipa I. Metode. U ovo istraživanje bilo je uključeno 8 kunića (soj Činičila), starosti 4 meseca, kod kojih je dijabetes melitus tipa I bio izazvan aloksanom. Kod svih životinja hirurški je urađen defekt kritičneveličine na kosti kalvarije (prečnika 12 mm), koji je popunjen autotransplantatom kosti i β-trikalcijum fosfatom (n = 4) ili je ostavljen da spontano zarasta kao kontrolni defekt (n = 4). Posle 4 nedelje, sve životinje su bile žrtvovane i koštani uzorci uzeti za histološku i histomorfometrijsku analizu. Pored deskriptivne histološke analize, urađena je i kvantitativna analiza novoformirane kosti, vezivnog tkiva i materijala za koštanu regeneraciju. Statistička analiza vršena je primenom Friedmanovog testa i post hock Vilkoksonovog neparametrijskog testa sa stepenom značajnosti od p  lt  0,05. Rezultati. Histološka analiza uzoraka kosti pokazala je prisustvo novoformirane kosti na periferiji defekta, dok je u centralom delu bilo prisutno vezivno tkivo, nezrelo koštano tkivo i dobro sjedinjeni neresorbovani materijal za regeneraciju kosti. Kontrolni uzorci nisu pokazali koštano zarastanje defekata. Značajno više novoformirane kosti bilo je prisutno u defektima regenerisanim autotransplantatom (53%) u poređenju sa kontrolnim defektima (7%), (p  lt  0,000) i defektima popunjenim β-trikalcijum fosfatom (30%), (p  lt  0,030). Takođe, značajna razlika uočena je i između grupe sa β-trikalcijum fosfatom i kontrolnim koštanim defektom (p  lt  0,008). Zaključak. Primena autotransplantata kosti značajno povećava uspešnost regeneracije kritičnih defekata kosti kalvarije kunića sa dijabetesom melitusom tipa I.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits
T1  - Histomorfometrijska analiza regeneracije kosti kod kunića sa dijabetesom melitusom posle primene autotransplantata kosti i beta-trikalcijum fosfata
VL  - 73
IS  - 12
SP  - 1132
EP  - 1138
DO  - 10.2298/VSP151125013Z
ER  - 

@article{
author = "Živadinović, Milka and Andrić, Miroslav and Milošević, Verica and Manojlović-Stojanoski, Milica and Prokić, Branislav and Prokić, Bogomir and Dimić, Aleksandar and Ćalasan, Dejan and Brković, Božidar",
year = "2016",
abstract = "Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as unfilled controls (n = 4). After 4 weeks of healing, animals were sacrificed and calvarial bone blocks were taken for histologic and histomorphometric analysis. Beside descriptive histologic evaluation, the percentage of new bone formation, connective tissue and residual graft were calculated. All parameters were statistically evaluated by Friedman Test and post hock Wilcoxon Singed Ranks Test with a significance of p  lt  0.05. Results. Histology revealed active new bone formation peripherally with centrally located connective tissue, newly formed woven bone and well incorporated residual grafts in all treated defects. Control samples showed no bone bridging of defects. There was a significantly more new bone in autogeonous graft (53%) compared with β-tricalcium phosphate (30%), (p  lt  0.030) and control (7%), (p  lt  0.000) groups. A significant difference was also recorded between β-tricalcium phosphate and control groups (p  lt  0.008). Conclusion. In the present study on the rabbit grafting model with induced diabetes mellitus type I, the effective bone regeneration of critical bone defects was obtained using autogenous bone graft., Uvod/Cilj. Mehanizam otežanog zarastanja tkiva kod dijabetesa melitusa zasnovan je na različitim promenama funkcije na tkivnom i ćelijskom nivou, usled prisutnih mikro- i makrovaskularnih promena. Kao hronično metaboličko oboljenje sa vaskularnim komplikacijama, dijabetes melitus zahvata i proces koštane regeneracije. Terapijski postupci u okviru regeneracije kosti obuhvataju primenu autotransplantata sa oseoinduktivnim delovanjem i sintetskih osteokonduktivnih materijala, kao što je i β-trikalcijum fosfat. Cilj ovog rada bio je da se ispita kvantitet i kvalitet novoformiranog koštanog tkiva posle korišćenja autotransplantata kosti i β-trikalcijum fosfata, na modelu kritičnog defekta kalvarije kunića sa eksperimentalno izazvanim dijabetesom melitusom tipa I. Metode. U ovo istraživanje bilo je uključeno 8 kunića (soj Činičila), starosti 4 meseca, kod kojih je dijabetes melitus tipa I bio izazvan aloksanom. Kod svih životinja hirurški je urađen defekt kritičneveličine na kosti kalvarije (prečnika 12 mm), koji je popunjen autotransplantatom kosti i β-trikalcijum fosfatom (n = 4) ili je ostavljen da spontano zarasta kao kontrolni defekt (n = 4). Posle 4 nedelje, sve životinje su bile žrtvovane i koštani uzorci uzeti za histološku i histomorfometrijsku analizu. Pored deskriptivne histološke analize, urađena je i kvantitativna analiza novoformirane kosti, vezivnog tkiva i materijala za koštanu regeneraciju. Statistička analiza vršena je primenom Friedmanovog testa i post hock Vilkoksonovog neparametrijskog testa sa stepenom značajnosti od p  lt  0,05. Rezultati. Histološka analiza uzoraka kosti pokazala je prisustvo novoformirane kosti na periferiji defekta, dok je u centralom delu bilo prisutno vezivno tkivo, nezrelo koštano tkivo i dobro sjedinjeni neresorbovani materijal za regeneraciju kosti. Kontrolni uzorci nisu pokazali koštano zarastanje defekata. Značajno više novoformirane kosti bilo je prisutno u defektima regenerisanim autotransplantatom (53%) u poređenju sa kontrolnim defektima (7%), (p  lt  0,000) i defektima popunjenim β-trikalcijum fosfatom (30%), (p  lt  0,030). Takođe, značajna razlika uočena je i između grupe sa β-trikalcijum fosfatom i kontrolnim koštanim defektom (p  lt  0,008). Zaključak. Primena autotransplantata kosti značajno povećava uspešnost regeneracije kritičnih defekata kosti kalvarije kunića sa dijabetesom melitusom tipa I.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits, Histomorfometrijska analiza regeneracije kosti kod kunića sa dijabetesom melitusom posle primene autotransplantata kosti i beta-trikalcijum fosfata",
volume = "73",
number = "12",
pages = "1132-1138",
doi = "10.2298/VSP151125013Z"
}

Živadinović, M., Andrić, M., Milošević, V., Manojlović-Stojanoski, M., Prokić, B., Prokić, B., Dimić, A., Ćalasan, D.,& Brković, B.. (2016). Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(12), 1132-1138.
https://doi.org/10.2298/VSP151125013Z

Živadinović M, Andrić M, Milošević V, Manojlović-Stojanoski M, Prokić B, Prokić B, Dimić A, Ćalasan D, Brković B. Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits. in Vojnosanitetski pregled. 2016;73(12):1132-1138.
doi:10.2298/VSP151125013Z .

Živadinović, Milka, Andrić, Miroslav, Milošević, Verica, Manojlović-Stojanoski, Milica, Prokić, Branislav, Prokić, Bogomir, Dimić, Aleksandar, Ćalasan, Dejan, Brković, Božidar, "Histomorphometric evaluation of bone regeneration using autogenous bone and beta-tricalcium phosphate in diabetic rabbits" in Vojnosanitetski pregled, 73, no. 12 (2016):1132-1138,
https://doi.org/10.2298/VSP151125013Z . .

TY  - JOUR
AU  - Brajković, Denis
AU  - Biočanin, Vladimir
AU  - Milić, Marija
AU  - Vučetić, Milan
AU  - Petrović, Renata
AU  - Brković, Božidar
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2044
AB  - Background/Aim. Surgical extraction of lower third molars is followed by mild or severe postoperative pain which peaks at maximal intensity in the first 12 hours and has a significant impact on a patient's postoperative quality of life. The use of long-acting local anaesthetics is a promising strategy to improve postoperative analgesia. The aim of the present study was to investigate analgesic parameters and patient satisfaction after using 0.5% levobupivacaine (Lbup), 0.5% bupivacaine (Bup) and 2% lidocaine with epinephrine 1:80,000 (Lid + Epi) for an inferior alveolar nerve block following lower third molar surgery. Methods. A total of 102 patients (ASA I) were divided into three groups, each of which received either 3 mL of Lbup, Bup or Lid + Epi. The intensity of postoperative analgesia was measured using a verbal rating scale (VRS). The total amounts of rescue analgesics were recorded on the first and during seven postoperative days. Patients satisfaction was noted using a modified verbal scales. Results. A significantly higher level of postoperative pain was recorded in Lid + Epi group compared to Bup and Lbup groups. No significant differences were seen between Bup and Lbup, but a significant reduction in the need for rescue analgesics was seen postoperatively in both Lbup and Bup (50%) in comparison with Lid + Epi (80%) in the first 24 hours. The same significant trend in rescue analgesic consumption was recorded for seven postoperative days. Patients' overall satisfaction was significantly lower for Lid + Epi (10%) than for Lbup (56%) and Bup (52%). Conclusion. The use of a new and long-acting local anaesthetic 0.5% levobupivacaine is clinically relevant and effective for an inferior alveolar nerve block and postoperative pain control after third molar surgery. In our study Lbup and Bup controlled postoperative pain more efficiently after lower third molar surgery compared to Lid + Epi.
AB  - Uvod/Cilj. Hirurško vađenje donjih impaktiranih umnjaka praćeno je bolom umerenog do jakog intenziteta, sa maksimalnim intenzitetom tokom prvih 12 sati, koji ima značajan uticaj na kvalitet života pacijenata u postoperativnom periodu. Upotreba dugodelujućih lokalnih anestetika predstavlja obećavajuću strategiju za poboljšanje postoperativne analgezije. Cilj ove studije bio je da se ispitaju analgeticki parametri i zadovoljstvo pacijenata postignutom analgezijom u postoperativnom periodu nakon primene 0,5% levobupivakaina (Lbup), 0,5% bupivakaina (Bup) i 2% lidokaina sa epinefrinom (1: 80,000) (Lid + Epi) za sprovodnu anesteziju donjeg alveolarnog nerva prilikom hirurškog vađenja donjih umnjaka. Metode. Ukupno 102 pacijenta (ASA I) bila su podeljena u tri grupe u zavisnosti od primljenog anestetika: 3 mL Lbup, 3 mL Bup ili 3 mL Lid + Epi. Intenzitet postoperativne analgezije registrovan je primenom verbalne rangirajuće skale (VRS). Zabeležena je ukupna količina primenjenih analgetika nakon prvog i sedmog postoperativnog dana. Zadovoljstvo pacijenata ocenjivano je na osnovu modifikovanih verbalnih skala. Rezultati. Značajno jači intenzitet postoperativnog bola zabeležen je u grupi Lid + Epi, u poređenju sa grupama Lbup i Bup. Značajno smanjenje potrebe za analgeticima u postoperativnom periodu zabeleženo u grupama Lbup i Bup (50%) u poređenju sa grupom Lid + Epi (80%) nakon 24 časa. Značajno smanjenje potrebe za postoperativnim analgeticima u grupama Lbup i Bup zabeleženo je i nakon 7 dana. Potpuno zadovoljstvo pacijenata postignutom analgezijom bilo je značajno slabije u grupi Lid + Epi (10%) u poređenju sa grupama Lbup (56%) i Bup (52%). Zaključak. Upotreba novog dugodelujućeg lokalnog anestetika 0,5% levobupivakaina klinički je relevantna i efikasna za sprovodnu anesteziju donjeg alveolarnog nerva i kontrolu postoperativnog bola nakon hirurškog vađenja donjih umnjaka. U našoj studiji Lbup i Bup bili su efikasniji u kontroli postoperativnog bola nakon hirurškog vađenja donjih umnjaka u poređenju sa Lid + Epi.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Quality of analgesia after lower third molar surgery: A randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine
T1  - Kvalitet analgezije nakon hirurškog vađenja donjih umnjaka - randomizovana, duplo slepa studija efikasnosti levobupivakaina, bupivakaina i lidokaina sa adrenalinom
VL  - 72
IS  - 1
SP  - 50
EP  - 56
DO  - 10.2298/VSP1501050B
ER  - 

@article{
author = "Brajković, Denis and Biočanin, Vladimir and Milić, Marija and Vučetić, Milan and Petrović, Renata and Brković, Božidar",
year = "2015",
abstract = "Background/Aim. Surgical extraction of lower third molars is followed by mild or severe postoperative pain which peaks at maximal intensity in the first 12 hours and has a significant impact on a patient's postoperative quality of life. The use of long-acting local anaesthetics is a promising strategy to improve postoperative analgesia. The aim of the present study was to investigate analgesic parameters and patient satisfaction after using 0.5% levobupivacaine (Lbup), 0.5% bupivacaine (Bup) and 2% lidocaine with epinephrine 1:80,000 (Lid + Epi) for an inferior alveolar nerve block following lower third molar surgery. Methods. A total of 102 patients (ASA I) were divided into three groups, each of which received either 3 mL of Lbup, Bup or Lid + Epi. The intensity of postoperative analgesia was measured using a verbal rating scale (VRS). The total amounts of rescue analgesics were recorded on the first and during seven postoperative days. Patients satisfaction was noted using a modified verbal scales. Results. A significantly higher level of postoperative pain was recorded in Lid + Epi group compared to Bup and Lbup groups. No significant differences were seen between Bup and Lbup, but a significant reduction in the need for rescue analgesics was seen postoperatively in both Lbup and Bup (50%) in comparison with Lid + Epi (80%) in the first 24 hours. The same significant trend in rescue analgesic consumption was recorded for seven postoperative days. Patients' overall satisfaction was significantly lower for Lid + Epi (10%) than for Lbup (56%) and Bup (52%). Conclusion. The use of a new and long-acting local anaesthetic 0.5% levobupivacaine is clinically relevant and effective for an inferior alveolar nerve block and postoperative pain control after third molar surgery. In our study Lbup and Bup controlled postoperative pain more efficiently after lower third molar surgery compared to Lid + Epi., Uvod/Cilj. Hirurško vađenje donjih impaktiranih umnjaka praćeno je bolom umerenog do jakog intenziteta, sa maksimalnim intenzitetom tokom prvih 12 sati, koji ima značajan uticaj na kvalitet života pacijenata u postoperativnom periodu. Upotreba dugodelujućih lokalnih anestetika predstavlja obećavajuću strategiju za poboljšanje postoperativne analgezije. Cilj ove studije bio je da se ispitaju analgeticki parametri i zadovoljstvo pacijenata postignutom analgezijom u postoperativnom periodu nakon primene 0,5% levobupivakaina (Lbup), 0,5% bupivakaina (Bup) i 2% lidokaina sa epinefrinom (1: 80,000) (Lid + Epi) za sprovodnu anesteziju donjeg alveolarnog nerva prilikom hirurškog vađenja donjih umnjaka. Metode. Ukupno 102 pacijenta (ASA I) bila su podeljena u tri grupe u zavisnosti od primljenog anestetika: 3 mL Lbup, 3 mL Bup ili 3 mL Lid + Epi. Intenzitet postoperativne analgezije registrovan je primenom verbalne rangirajuće skale (VRS). Zabeležena je ukupna količina primenjenih analgetika nakon prvog i sedmog postoperativnog dana. Zadovoljstvo pacijenata ocenjivano je na osnovu modifikovanih verbalnih skala. Rezultati. Značajno jači intenzitet postoperativnog bola zabeležen je u grupi Lid + Epi, u poređenju sa grupama Lbup i Bup. Značajno smanjenje potrebe za analgeticima u postoperativnom periodu zabeleženo u grupama Lbup i Bup (50%) u poređenju sa grupom Lid + Epi (80%) nakon 24 časa. Značajno smanjenje potrebe za postoperativnim analgeticima u grupama Lbup i Bup zabeleženo je i nakon 7 dana. Potpuno zadovoljstvo pacijenata postignutom analgezijom bilo je značajno slabije u grupi Lid + Epi (10%) u poređenju sa grupama Lbup (56%) i Bup (52%). Zaključak. Upotreba novog dugodelujućeg lokalnog anestetika 0,5% levobupivakaina klinički je relevantna i efikasna za sprovodnu anesteziju donjeg alveolarnog nerva i kontrolu postoperativnog bola nakon hirurškog vađenja donjih umnjaka. U našoj studiji Lbup i Bup bili su efikasniji u kontroli postoperativnog bola nakon hirurškog vađenja donjih umnjaka u poređenju sa Lid + Epi.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Quality of analgesia after lower third molar surgery: A randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine, Kvalitet analgezije nakon hirurškog vađenja donjih umnjaka - randomizovana, duplo slepa studija efikasnosti levobupivakaina, bupivakaina i lidokaina sa adrenalinom",
volume = "72",
number = "1",
pages = "50-56",
doi = "10.2298/VSP1501050B"
}

Brajković, D., Biočanin, V., Milić, M., Vučetić, M., Petrović, R.,& Brković, B.. (2015). Quality of analgesia after lower third molar surgery: A randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(1), 50-56.
https://doi.org/10.2298/VSP1501050B

Brajković D, Biočanin V, Milić M, Vučetić M, Petrović R, Brković B. Quality of analgesia after lower third molar surgery: A randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine. in Vojnosanitetski pregled. 2015;72(1):50-56.
doi:10.2298/VSP1501050B .

Brajković, Denis, Biočanin, Vladimir, Milić, Marija, Vučetić, Milan, Petrović, Renata, Brković, Božidar, "Quality of analgesia after lower third molar surgery: A randomised, double-blind study of levobupivacaine, bupivacaine and lidocaine with epinephrine" in Vojnosanitetski pregled, 72, no. 1 (2015):50-56,
https://doi.org/10.2298/VSP1501050B . .

TY  - JOUR
AU  - Biočanin, Vladimir
AU  - Brajković, Denis
AU  - Stevanović, Momir
AU  - Tatić, Zoran
AU  - Andrić, Miroslav
AU  - Brković, Božidar
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2029
AB  - Introduction. Therapeutic approach to jaw cysts may depend on their dimensions and localization. Enucleation of cystic lesion is not always preferable in the first act, especially if large cysts are in close proximity to important anatomical structures. The aim of this paper was to present the outcome of the treatment protocol comprising preoperative decompression and subsequent enucleation of a large maxillary cyst. Case re-port. A 21-year-old male patient with large asymptomatic radicular cyst in the right maxillary sinus was presented to our clinic. Conebeam computed tomography (CBCT) showed a large cyst, which perforated the right anterior maxillary wall by 1.5 cm, and was in the intimate contact with the orbital floor. Surgical treatment of the cystic lesion comprised: preoperative decompression with biopsy in the first act and enucleation, performed under general anesthesia, 6 months after the observation period. Conclusion. Decompression with subsequent enucleation proved to be effective treatment of large radicular cyst in maxillary sinus with low-morbidity.
AB  - Uvod. Terapijski pristup cistama vilice može zavisiti od njihovih dimenzija i lokalizacije. Enukleacija cistične lezije često nije pogodna u prvom aktu ako se velika cista nalazi u blizini važnih anatomskih struktura. Cilj ovog rada bio je da se prikaže ishod lečenja velike ciste u maksilarnom sinusu koji je podrazumevao preoperativnu dekompresiju i odloženu enukleaciju. Prikaz bolesnika. Prikazan je bolesnik, star 21 godinu, sa velikom, asimptomatskom, radikularnom cistom u maksilarnom sinusu. Radiografska dijagnostika pomoću cone-beam kompjuterizovane tomografije (CBCT), pokazala je prisustvo velike cistične lezije koja je probila prednji maksilarni zid (1,5 cm) i bila u bliskom kontaktu sa podom orbite. Hirurški tretman cistične lezije uključio je preoperativnu dekompresiju i biopsiju u prvom aktu i enukleaciju u opštoj anesteziji nakon 6 meseci. Zaključak. De-kompresija i odložena enukleacija pokazale su se efikasnim terapijskim pristupom kod lečenje velike radikularne ciste maksilarnog sinusa uz mali morbiditet.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report
T1  - Dekompresija kao delotvorni primarni pristup radikularnoj cisti u maksilarnom sinusu
VL  - 72
IS  - 7
SP  - 634
EP  - 638
DO  - 10.2298/vsp140317043B
ER  - 

@article{
author = "Biočanin, Vladimir and Brajković, Denis and Stevanović, Momir and Tatić, Zoran and Andrić, Miroslav and Brković, Božidar",
year = "2015",
abstract = "Introduction. Therapeutic approach to jaw cysts may depend on their dimensions and localization. Enucleation of cystic lesion is not always preferable in the first act, especially if large cysts are in close proximity to important anatomical structures. The aim of this paper was to present the outcome of the treatment protocol comprising preoperative decompression and subsequent enucleation of a large maxillary cyst. Case re-port. A 21-year-old male patient with large asymptomatic radicular cyst in the right maxillary sinus was presented to our clinic. Conebeam computed tomography (CBCT) showed a large cyst, which perforated the right anterior maxillary wall by 1.5 cm, and was in the intimate contact with the orbital floor. Surgical treatment of the cystic lesion comprised: preoperative decompression with biopsy in the first act and enucleation, performed under general anesthesia, 6 months after the observation period. Conclusion. Decompression with subsequent enucleation proved to be effective treatment of large radicular cyst in maxillary sinus with low-morbidity., Uvod. Terapijski pristup cistama vilice može zavisiti od njihovih dimenzija i lokalizacije. Enukleacija cistične lezije često nije pogodna u prvom aktu ako se velika cista nalazi u blizini važnih anatomskih struktura. Cilj ovog rada bio je da se prikaže ishod lečenja velike ciste u maksilarnom sinusu koji je podrazumevao preoperativnu dekompresiju i odloženu enukleaciju. Prikaz bolesnika. Prikazan je bolesnik, star 21 godinu, sa velikom, asimptomatskom, radikularnom cistom u maksilarnom sinusu. Radiografska dijagnostika pomoću cone-beam kompjuterizovane tomografije (CBCT), pokazala je prisustvo velike cistične lezije koja je probila prednji maksilarni zid (1,5 cm) i bila u bliskom kontaktu sa podom orbite. Hirurški tretman cistične lezije uključio je preoperativnu dekompresiju i biopsiju u prvom aktu i enukleaciju u opštoj anesteziji nakon 6 meseci. Zaključak. De-kompresija i odložena enukleacija pokazale su se efikasnim terapijskim pristupom kod lečenje velike radikularne ciste maksilarnog sinusa uz mali morbiditet.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report, Dekompresija kao delotvorni primarni pristup radikularnoj cisti u maksilarnom sinusu",
volume = "72",
number = "7",
pages = "634-638",
doi = "10.2298/vsp140317043B"
}

Biočanin, V., Brajković, D., Stevanović, M., Tatić, Z., Andrić, M.,& Brković, B.. (2015). Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 72(7), 634-638.
https://doi.org/10.2298/vsp140317043B

Biočanin V, Brajković D, Stevanović M, Tatić Z, Andrić M, Brković B. Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report. in Vojnosanitetski pregled. 2015;72(7):634-638.
doi:10.2298/vsp140317043B .

Biočanin, Vladimir, Brajković, Denis, Stevanović, Momir, Tatić, Zoran, Andrić, Miroslav, Brković, Božidar, "Decompression as an effective primary approach to large radicular cyst in the maxillary sinus: A case report" in Vojnosanitetski pregled, 72, no. 7 (2015):634-638,
https://doi.org/10.2298/vsp140317043B . .

TY  - CONF
AU  - Miljić, P.
AU  - Bodrozić, J.
AU  - Elezović, I.
AU  - Jurišić, Milan
AU  - Brković, Božidar
AU  - Antić, D.
AU  - Leković, D.
AU  - Mitrović, M.
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1972
PB  - Wiley-Blackwell, Hoboken
C3  - Journal of Thrombosis & Haemostasis
T1  - Factors influencing risk of bleeding after dental extraction in hemophilia patients
VL  - 13
SP  - 586
EP  - 587
UR  - https://hdl.handle.net/21.15107/rcub_smile_1972
ER  - 

@conference{
author = "Miljić, P. and Bodrozić, J. and Elezović, I. and Jurišić, Milan and Brković, Božidar and Antić, D. and Leković, D. and Mitrović, M.",
year = "2015",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Thrombosis & Haemostasis",
title = "Factors influencing risk of bleeding after dental extraction in hemophilia patients",
volume = "13",
pages = "586-587",
url = "https://hdl.handle.net/21.15107/rcub_smile_1972"
}

Miljić, P., Bodrozić, J., Elezović, I., Jurišić, M., Brković, B., Antić, D., Leković, D.,& Mitrović, M.. (2015). Factors influencing risk of bleeding after dental extraction in hemophilia patients. in Journal of Thrombosis & Haemostasis
Wiley-Blackwell, Hoboken., 13, 586-587.
https://hdl.handle.net/21.15107/rcub_smile_1972

Miljić P, Bodrozić J, Elezović I, Jurišić M, Brković B, Antić D, Leković D, Mitrović M. Factors influencing risk of bleeding after dental extraction in hemophilia patients. in Journal of Thrombosis & Haemostasis. 2015;13:586-587.
https://hdl.handle.net/21.15107/rcub_smile_1972 .

Miljić, P., Bodrozić, J., Elezović, I., Jurišić, Milan, Brković, Božidar, Antić, D., Leković, D., Mitrović, M., "Factors influencing risk of bleeding after dental extraction in hemophilia patients" in Journal of Thrombosis & Haemostasis, 13 (2015):586-587,
https://hdl.handle.net/21.15107/rcub_smile_1972 .