TY  - JOUR
AU  - Miletić, Maja
AU  - Stojanović, R.
AU  - Pajić, O.
AU  - Bugarski, Diana
AU  - Mojsilović, S.
AU  - Cokić, V.
AU  - Milenković, P.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1759
AB  - Background & objectives: The interleukin (IL)-17 producing T-helper cells have been linked to pathogenesis of autoimmunity and mostly investigated in rheumatoid arthritis (RA). In this study we tested the IL-17 levels, as well as the levels of nitric oxide (NO) as possible IL-17-induced product, in patients with primary Sjogren's syndrome (pSS), an intricate and complex chronic autoimmune disorder of exocrine glands. Methods: Serum IL-17 levels and nitrite concentrations determined in patients with pSS (n=30) were compared with the values obtained in patients with RA (n=10) and healthy controls (n=15). The values obtained for 11,17 in pSS patients were also associated with the patients' clinical characteristics, particularly the rheumatoid factor (RF) and total antinuclear antibodies (tANA) levels. Results: Serum concentrations of IL-17 were significantly (P lt 0.01) higher in patients with pSS (12.9 +/- 28.0 pg/ml) as compared to those obtained in healthy individuals (0.2 +/- 0.6 pg/ml), but not as high as the values obtained for the patients with RA (34.5 +/- 56.2 pg/ml). The mean IL-17 levels were significantly (P lt 0.05) higher in the pSS patients positive for rheumatoid factor (20.3 +/- 33.3 pg/ml) than in RF-negatives (0.3 +/- 0.6 pg/ml). Mean serum concentrations of IL-17 were also higher in antinuclear antibody (ANA)positive samples (19.8 +/- 33.5 pg/ml) in comparison to ANA-negative sera (1.1 +/- 3.1 pg/ml) (P lt 0.05). The NO levels also showed elevated values in both pSS and RA patients, as compared to the healthy controls, since mean nitrite levels in patients with pSS and RA were 38.2 +/- 29.2 mu M and 41.7 +/- 21.1 mu M, respectively, while those in healthy controls were significantly lower, at 19.2 +/- 10.5 mu M. Interpretation & conclusions: The findings of this study showed that there was increased IL-17 and NO production in patients with primary SS, especially if they had associated elevated rheumatoid factor and antinuclear antibody values.
PB  - Medknow Publications & Media Pvt Ltd, Mumbai
T2  - Indian Journal of Medical Research
T1  - Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome
VL  - 135
IS  - 4
SP  - 513
EP  - 519
UR  - https://hdl.handle.net/21.15107/rcub_smile_1759
ER  - 

@article{
author = "Miletić, Maja and Stojanović, R. and Pajić, O. and Bugarski, Diana and Mojsilović, S. and Cokić, V. and Milenković, P.",
year = "2012",
abstract = "Background & objectives: The interleukin (IL)-17 producing T-helper cells have been linked to pathogenesis of autoimmunity and mostly investigated in rheumatoid arthritis (RA). In this study we tested the IL-17 levels, as well as the levels of nitric oxide (NO) as possible IL-17-induced product, in patients with primary Sjogren's syndrome (pSS), an intricate and complex chronic autoimmune disorder of exocrine glands. Methods: Serum IL-17 levels and nitrite concentrations determined in patients with pSS (n=30) were compared with the values obtained in patients with RA (n=10) and healthy controls (n=15). The values obtained for 11,17 in pSS patients were also associated with the patients' clinical characteristics, particularly the rheumatoid factor (RF) and total antinuclear antibodies (tANA) levels. Results: Serum concentrations of IL-17 were significantly (P lt 0.01) higher in patients with pSS (12.9 +/- 28.0 pg/ml) as compared to those obtained in healthy individuals (0.2 +/- 0.6 pg/ml), but not as high as the values obtained for the patients with RA (34.5 +/- 56.2 pg/ml). The mean IL-17 levels were significantly (P lt 0.05) higher in the pSS patients positive for rheumatoid factor (20.3 +/- 33.3 pg/ml) than in RF-negatives (0.3 +/- 0.6 pg/ml). Mean serum concentrations of IL-17 were also higher in antinuclear antibody (ANA)positive samples (19.8 +/- 33.5 pg/ml) in comparison to ANA-negative sera (1.1 +/- 3.1 pg/ml) (P lt 0.05). The NO levels also showed elevated values in both pSS and RA patients, as compared to the healthy controls, since mean nitrite levels in patients with pSS and RA were 38.2 +/- 29.2 mu M and 41.7 +/- 21.1 mu M, respectively, while those in healthy controls were significantly lower, at 19.2 +/- 10.5 mu M. Interpretation & conclusions: The findings of this study showed that there was increased IL-17 and NO production in patients with primary SS, especially if they had associated elevated rheumatoid factor and antinuclear antibody values.",
publisher = "Medknow Publications & Media Pvt Ltd, Mumbai",
journal = "Indian Journal of Medical Research",
title = "Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome",
volume = "135",
number = "4",
pages = "513-519",
url = "https://hdl.handle.net/21.15107/rcub_smile_1759"
}

Miletić, M., Stojanović, R., Pajić, O., Bugarski, D., Mojsilović, S., Cokić, V.,& Milenković, P.. (2012). Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome. in Indian Journal of Medical Research
Medknow Publications & Media Pvt Ltd, Mumbai., 135(4), 513-519.
https://hdl.handle.net/21.15107/rcub_smile_1759

Miletić M, Stojanović R, Pajić O, Bugarski D, Mojsilović S, Cokić V, Milenković P. Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome. in Indian Journal of Medical Research. 2012;135(4):513-519.
https://hdl.handle.net/21.15107/rcub_smile_1759 .

Miletić, Maja, Stojanović, R., Pajić, O., Bugarski, Diana, Mojsilović, S., Cokić, V., Milenković, P., "Serum interleukin-17 & nitric oxide levels in patients with primary Sjogren's syndrome" in Indian Journal of Medical Research, 135, no. 4 (2012):513-519,
https://hdl.handle.net/21.15107/rcub_smile_1759 .

TY  - CONF
AU  - Dokmanović-Miletić, Maja
AU  - Stojanović, R. M.
AU  - Pajić, O.
AU  - Bugarski, Diana
AU  - Marković, D.
AU  - Milenković, P. B.
PY  - 2006
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1315
PB  - B M J Publishing Group, London
C3  - Annals of the Rheumatic Diseases
T1  - Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies
VL  - 65
SP  - 299
EP  - 299
UR  - https://hdl.handle.net/21.15107/rcub_smile_1315
ER  - 

@conference{
author = "Dokmanović-Miletić, Maja and Stojanović, R. M. and Pajić, O. and Bugarski, Diana and Marković, D. and Milenković, P. B.",
year = "2006",
publisher = "B M J Publishing Group, London",
journal = "Annals of the Rheumatic Diseases",
title = "Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies",
volume = "65",
pages = "299-299",
url = "https://hdl.handle.net/21.15107/rcub_smile_1315"
}

Dokmanović-Miletić, M., Stojanović, R. M., Pajić, O., Bugarski, D., Marković, D.,& Milenković, P. B.. (2006). Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies. in Annals of the Rheumatic Diseases
B M J Publishing Group, London., 65, 299-299.
https://hdl.handle.net/21.15107/rcub_smile_1315

Dokmanović-Miletić M, Stojanović RM, Pajić O, Bugarski D, Marković D, Milenković PB. Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies. in Annals of the Rheumatic Diseases. 2006;65:299-299.
https://hdl.handle.net/21.15107/rcub_smile_1315 .

Dokmanović-Miletić, Maja, Stojanović, R. M., Pajić, O., Bugarski, Diana, Marković, D., Milenković, P. B., "Incidence of anti-alfa fodrin antibodies in primary sjogren syndrome and its correlation with anti ro/SS-A and anti La/SS-B antibodies" in Annals of the Rheumatic Diseases, 65 (2006):299-299,
https://hdl.handle.net/21.15107/rcub_smile_1315 .