TY  - JOUR
AU  - Anđelković, Marko
AU  - Tihaček-Šojić, Ljiljana
AU  - Milić-Lemić, Aleksandra
AU  - Nikolić, Nadja
AU  - Kannosh, Ibrahim
AU  - Milašin, Jelena
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2194
AB  - Purpose: To determine if wearing complete dentures can cause changes in prevalence of some of the most common periodontal pathogens in elderly edentulous patients. The need for understanding the composition of oral microflora in edentulous patients has been recognized by some authors, but no studies have dealt with the changes that occur in periodontal pathogens' prevalence as a result of complete dentures. Materials and Methods: A total of 30 edentulous elderly (average age 71) patients participated in the study. Complete dentures were fabricated for each patient, and the residual alveolar ridges were swabbed before denture insertion. After a period of 6 months swabs were taken again. Identification of P. intermedia, A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, and F. nucleatum was done by the polymerase chain reaction (PCR) method and primers specific for each microorganism. Results: A noticeable increase in the presence of periodontal pathogens was observed after 6 months of denture wearing; targeted bacteria were identified in 17 pre-insertion samples compared to 28 post-insertion samples. The McNemar test was used to compare the prevalence of periodontal pathogenic bacteria before and after dental treatment. p lt 0.05 indicated statistical significance. Three microorganisms showed a statistically significant difference between the first and second swabbing-A. actinomycetemcomitans (6.7% vs. 40.0%, p = 0.006), P. intermedia (30.0% vs. 73.3%, p = 0.004), and T. forsythia (6.7% vs. 30.0%, p = 0.004). There was also an increase in bacteria co-associations 6 months post-insertion of complete dentures. Conclusions: The results of the present study suggested that wearing complete dentures caused a considerable increase of periodontopathic bacteria prevalence in elderly patients. Better understanding of oral microflora and the impact dental treatment has on bacterial colonies is important in modern dentistry.
PB  - Wiley, Hoboken
T2  - Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry
T1  - Does the Prevalence of Periodontal Pathogens Change in Elderly Edentulous Patients after Complete Denture Treatment?
VL  - 26
IS  - 5
SP  - 364
EP  - 369
DO  - 10.1111/jopr.12402
ER  - 

@article{
author = "Anđelković, Marko and Tihaček-Šojić, Ljiljana and Milić-Lemić, Aleksandra and Nikolić, Nadja and Kannosh, Ibrahim and Milašin, Jelena",
year = "2017",
abstract = "Purpose: To determine if wearing complete dentures can cause changes in prevalence of some of the most common periodontal pathogens in elderly edentulous patients. The need for understanding the composition of oral microflora in edentulous patients has been recognized by some authors, but no studies have dealt with the changes that occur in periodontal pathogens' prevalence as a result of complete dentures. Materials and Methods: A total of 30 edentulous elderly (average age 71) patients participated in the study. Complete dentures were fabricated for each patient, and the residual alveolar ridges were swabbed before denture insertion. After a period of 6 months swabs were taken again. Identification of P. intermedia, A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, and F. nucleatum was done by the polymerase chain reaction (PCR) method and primers specific for each microorganism. Results: A noticeable increase in the presence of periodontal pathogens was observed after 6 months of denture wearing; targeted bacteria were identified in 17 pre-insertion samples compared to 28 post-insertion samples. The McNemar test was used to compare the prevalence of periodontal pathogenic bacteria before and after dental treatment. p lt 0.05 indicated statistical significance. Three microorganisms showed a statistically significant difference between the first and second swabbing-A. actinomycetemcomitans (6.7% vs. 40.0%, p = 0.006), P. intermedia (30.0% vs. 73.3%, p = 0.004), and T. forsythia (6.7% vs. 30.0%, p = 0.004). There was also an increase in bacteria co-associations 6 months post-insertion of complete dentures. Conclusions: The results of the present study suggested that wearing complete dentures caused a considerable increase of periodontopathic bacteria prevalence in elderly patients. Better understanding of oral microflora and the impact dental treatment has on bacterial colonies is important in modern dentistry.",
publisher = "Wiley, Hoboken",
journal = "Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry",
title = "Does the Prevalence of Periodontal Pathogens Change in Elderly Edentulous Patients after Complete Denture Treatment?",
volume = "26",
number = "5",
pages = "364-369",
doi = "10.1111/jopr.12402"
}

Anđelković, M., Tihaček-Šojić, L., Milić-Lemić, A., Nikolić, N., Kannosh, I.,& Milašin, J.. (2017). Does the Prevalence of Periodontal Pathogens Change in Elderly Edentulous Patients after Complete Denture Treatment?. in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry
Wiley, Hoboken., 26(5), 364-369.
https://doi.org/10.1111/jopr.12402

Anđelković M, Tihaček-Šojić L, Milić-Lemić A, Nikolić N, Kannosh I, Milašin J. Does the Prevalence of Periodontal Pathogens Change in Elderly Edentulous Patients after Complete Denture Treatment?. in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry. 2017;26(5):364-369.
doi:10.1111/jopr.12402 .

Anđelković, Marko, Tihaček-Šojić, Ljiljana, Milić-Lemić, Aleksandra, Nikolić, Nadja, Kannosh, Ibrahim, Milašin, Jelena, "Does the Prevalence of Periodontal Pathogens Change in Elderly Edentulous Patients after Complete Denture Treatment?" in Journal of Prosthodontics-Implant Esthetic & Reconstructive Dentistry, 26, no. 5 (2017):364-369,
https://doi.org/10.1111/jopr.12402 . .

TY  - JOUR
AU  - Latković, Marina
AU  - Ranin, Lazar
AU  - Teodorović, Nevenka
AU  - Anđelković, Marko
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2266
AB  - Background/Aim. Helicobacter (H.) pylori is a widespread bacterium and its involvement in pathogenesis of gastric diseases is well-known. However, H. pylori role in etiology of other histologically similar conditions, especially recurrent aphthous stomatitis (RAS) is still controversial. Research regarding H. pylori and its association with RAS, as well as the treatment options were always conducted on patients with diagnosed gastric problems. The aim of this study was to determine whether H. pylori is present in the oral cavity of patients suffering from RAS but without any symptoms or medical history of gastric disease. Methods. A total of 15 patients with RAS participated in the study. None of the participants suffered from any gastrointestinal disorders. Two dental plaque samples from each participant were collected. The first was analyzed using rapid urease test and the second one was put in transport medium and sent for cultivation. The sensitivity of H. pylori to antibiotics was established using disk diffusion method of sensitivity testing for every patient individually and adequate therapy was prescribed. Results. Before the treatment the mean annual recurrence rate of RAS was 8.1 ± 2.1, with the average number of lesions being 3.9 ± 1.9. During the 12-month observation period after the eradication therapy, none of the patients reported recurrence of aphthous lesions. The treatment was successful in all cases. Conclusion. This study shows that RAS can be effectively treated by successful eradication of oral H. pylori, and that RAS could be possibly considered as an early warning sign of potential gastric infection by H. pilory.
AB  - Uvod/Cilj. Helicobacter (H.) pylori je široko rasprostanjena bakterija i njen uticaj na nastanak gastričkih oboljenja vrlo dobro je dokumentovan. Međutim, uloga H. pylori u patogenezi histološki sličnih oboljenja, posebno rekurentnog aftoznog stomatitisa (RAS), nije dovoljno istražena. Dosadašnje studije, u kojima je ispitivana veza između H. pylori i RAS, kao i moguće terapijske opcije, bile su usmerene ka bolesnicima sa prethodno dijagnostikovanim gastričkim smetnjama. Cilj ovog istraživanja bio je da se utvrdi da li je H. pylori prisutan u usnoj duplji i kod bolesnika bez simptoma i istorije gastričkih oboljenja koji pate od RAS. Metode. U studiji je učestvovalo 15 bolesnika koji pate od RAS. Bolesnici nisu imali smetnje vezane za gornji deo digestivnog trakta. Po dva uzorka dentalnog plaka prikupljena su od svakog bolesnika. Jedan plak je ispitivan uz pomoć brzog ureaza testa, dok je drugi stavljen u transportni medijum i poslat na kultivaciju. Osetljivost H. pylori na antibiotike određivana je uz pomoć antibiograma za svakog bolesnika posebno i, u skladu sa rezultatima, prepisivana je odgovarajuća terapija. Rezultati. Pre lečenja prosečan broj epizoda RAS tokom godine iznosio je 8,1 ± 2,1, sa prosečno 3,9 ± 1,9 aftoznih lezija. Tokom 12-mesečnog perioda nakon eradikacione terapije, ni kod jednog bolesnika nije došlo do ponovne pojave afti. Terapija je bila uspešna kod svih bolesnika. Zaključak. Rezultati ovog istraživanja pokazuju da se RAS može uspešno lečiti eradikacijom H. pylori i da se sama pojava RAS može posmatrati kao rano upozorenje na moguću gastričku infekciju.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Eradication of Helicobacter pylori in patients without gastric symptoms suffering from recurrent aphthous stomatitis: A pilot study
T1  - Eradikacija Helicobacter pylori kod bolesnika bez gastričkih simptoma koji imaju rekurentni aftozni stomatitis - pilot studija
VL  - 74
IS  - 7
SP  - 672
EP  - 675
DO  - 10.2298/VSP151014113L
ER  - 

@article{
author = "Latković, Marina and Ranin, Lazar and Teodorović, Nevenka and Anđelković, Marko",
year = "2017",
abstract = "Background/Aim. Helicobacter (H.) pylori is a widespread bacterium and its involvement in pathogenesis of gastric diseases is well-known. However, H. pylori role in etiology of other histologically similar conditions, especially recurrent aphthous stomatitis (RAS) is still controversial. Research regarding H. pylori and its association with RAS, as well as the treatment options were always conducted on patients with diagnosed gastric problems. The aim of this study was to determine whether H. pylori is present in the oral cavity of patients suffering from RAS but without any symptoms or medical history of gastric disease. Methods. A total of 15 patients with RAS participated in the study. None of the participants suffered from any gastrointestinal disorders. Two dental plaque samples from each participant were collected. The first was analyzed using rapid urease test and the second one was put in transport medium and sent for cultivation. The sensitivity of H. pylori to antibiotics was established using disk diffusion method of sensitivity testing for every patient individually and adequate therapy was prescribed. Results. Before the treatment the mean annual recurrence rate of RAS was 8.1 ± 2.1, with the average number of lesions being 3.9 ± 1.9. During the 12-month observation period after the eradication therapy, none of the patients reported recurrence of aphthous lesions. The treatment was successful in all cases. Conclusion. This study shows that RAS can be effectively treated by successful eradication of oral H. pylori, and that RAS could be possibly considered as an early warning sign of potential gastric infection by H. pilory., Uvod/Cilj. Helicobacter (H.) pylori je široko rasprostanjena bakterija i njen uticaj na nastanak gastričkih oboljenja vrlo dobro je dokumentovan. Međutim, uloga H. pylori u patogenezi histološki sličnih oboljenja, posebno rekurentnog aftoznog stomatitisa (RAS), nije dovoljno istražena. Dosadašnje studije, u kojima je ispitivana veza između H. pylori i RAS, kao i moguće terapijske opcije, bile su usmerene ka bolesnicima sa prethodno dijagnostikovanim gastričkim smetnjama. Cilj ovog istraživanja bio je da se utvrdi da li je H. pylori prisutan u usnoj duplji i kod bolesnika bez simptoma i istorije gastričkih oboljenja koji pate od RAS. Metode. U studiji je učestvovalo 15 bolesnika koji pate od RAS. Bolesnici nisu imali smetnje vezane za gornji deo digestivnog trakta. Po dva uzorka dentalnog plaka prikupljena su od svakog bolesnika. Jedan plak je ispitivan uz pomoć brzog ureaza testa, dok je drugi stavljen u transportni medijum i poslat na kultivaciju. Osetljivost H. pylori na antibiotike određivana je uz pomoć antibiograma za svakog bolesnika posebno i, u skladu sa rezultatima, prepisivana je odgovarajuća terapija. Rezultati. Pre lečenja prosečan broj epizoda RAS tokom godine iznosio je 8,1 ± 2,1, sa prosečno 3,9 ± 1,9 aftoznih lezija. Tokom 12-mesečnog perioda nakon eradikacione terapije, ni kod jednog bolesnika nije došlo do ponovne pojave afti. Terapija je bila uspešna kod svih bolesnika. Zaključak. Rezultati ovog istraživanja pokazuju da se RAS može uspešno lečiti eradikacijom H. pylori i da se sama pojava RAS može posmatrati kao rano upozorenje na moguću gastričku infekciju.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Eradication of Helicobacter pylori in patients without gastric symptoms suffering from recurrent aphthous stomatitis: A pilot study, Eradikacija Helicobacter pylori kod bolesnika bez gastričkih simptoma koji imaju rekurentni aftozni stomatitis - pilot studija",
volume = "74",
number = "7",
pages = "672-675",
doi = "10.2298/VSP151014113L"
}

Latković, M., Ranin, L., Teodorović, N.,& Anđelković, M.. (2017). Eradication of Helicobacter pylori in patients without gastric symptoms suffering from recurrent aphthous stomatitis: A pilot study. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 74(7), 672-675.
https://doi.org/10.2298/VSP151014113L

Latković M, Ranin L, Teodorović N, Anđelković M. Eradication of Helicobacter pylori in patients without gastric symptoms suffering from recurrent aphthous stomatitis: A pilot study. in Vojnosanitetski pregled. 2017;74(7):672-675.
doi:10.2298/VSP151014113L .

Latković, Marina, Ranin, Lazar, Teodorović, Nevenka, Anđelković, Marko, "Eradication of Helicobacter pylori in patients without gastric symptoms suffering from recurrent aphthous stomatitis: A pilot study" in Vojnosanitetski pregled, 74, no. 7 (2017):672-675,
https://doi.org/10.2298/VSP151014113L . .

TY  - JOUR
AU  - Miljuš, Dušan
AU  - Tihaček-Šojić, Ljiljana
AU  - Milić-Lemić, Aleksandra
AU  - Anđelković, Marko
PY  - 2014
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1903
AB  - Background/Aim. Obstructive sleep apnea (OSA) is one of the most prevalent sleep disorders. It is recognized as a serious risk factor for car and workplace accidents due to daytime sleepiness, and factor for coronary heart diseases and stroke. The aim of this study was to examine the effectiveness of oral appliances for mandibular advance in treating mild to moderate OSA. Methods. A total of 15 patients were included in this study, all diagnosed with mild or moderate OSA. Oral appliances were custom made for each patient in protrusive position at 50% of maximum mandibular advancement. The patients were given instructions not to sleep on their backs and avoid alcohol consumption during the study as these are the factors that can contribute to symptoms progression. Results. Complete and partial treatment success was achieve in 14 of the patients. Apnea-hypopnea index values were significantly lower (p  lt  0.05) at the end of a 6-month observation period compared to those at the treatment beginning. A great improvement in symptoms was observed, with daytime sleepiness index values significantly reduced already within the first month of the treatment. Conclusion. Treatment of obstructive sleep apnea with oral appliances has proven successful. Patients were comfortable using oral appliances and were ready to wear them for prolonged period of time. Use of oral appliances is very common in the world and should not be discarded. They are also very comfortable, practical and affordable comparing to continuous positive airway pressure (CPAP) apparatus, not to mention surgery. Use of oral appliances is safe and very well tolerated, and ought to be offered to patients with OSA.
AB  - Uvod/Cilj. Opstruktivna apneja u snu je jedan od najčešćih poremećaja spavanja. Dokazano je da su bolesnici koji pate od ovog poremećaja skloniji saobraćajnim nezgodama i povredama na radu, kao i da su izloženi većem riziku od nastanka koronarne bolesti srca i moždanog udara. Cilj ovog istraživanja bio je da se utvrdi uspešnost terapije blage i umerene opstruktivne apneje u snu oralnim aparatima. Metode. Ukupno 15 bolesnika sa prethodno uspostavljenom dijagnozom blage ili umerene opstruktivne apneje u snu bilo je uključeno u istraživanje. Oralni aparati su individualno urađeni za svakog bolesnika, sa mandibulom u protruzionom položaju 50% od maksimalnog. Bolesnicima je preporučeno da izbegavaju spavanje na leđima i unošenje alkohola tokom trajanja studije, jer ovi faktori mogu uticati na pogoršanje simptoma. Rezultati. Potpuni i delimični uspeh terapije postignut je kod 14 bolesnika. Vrednosti apneja-hipopneja indeksa bile su statistički značajno niže (p  lt  0,05) od početnih vrednosti na kraju 6-mesečnog perioda posmatranja. Registrovano je i značajno poboljšanje simptoma, kao i značajno umanjenje vretnosti indeksa dnevne pospanosti već posle prvog meseca terapije. Zaključak. Oralni aparati su bili uspešni u lečenju opstruktivne apneje u snu. Bolesnici su iskazali veliku lagodnost i bili su spremni da nose oralne aparate i duži vremenski period. Upotreba oralnih aparata je uobičajena u svetu, i ne treba da bude zanemarena. Vrlo su praktični, lagodni za nošenje i pristupačniji u poređenju sa aparatom za kontinuirani pozitivni pritisak u disajnim putevima (CPAP), a pogotovo sa hirurškom intervencijom. Upotreba oralnih aparata je bezbedna i trebalo bi je ponuditi bolesnicima kao jedno od mogućih rešenja.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Treatment of obstructive sleep apnea patients using oral appliances: Our experiences
T1  - Lečenje opstruktivne apneje u snu pomoću oralnih aparata - naša iskustva
VL  - 71
IS  - 7
SP  - 623
EP  - 626
DO  - 10.2298/VSP121129010M
ER  - 

@article{
author = "Miljuš, Dušan and Tihaček-Šojić, Ljiljana and Milić-Lemić, Aleksandra and Anđelković, Marko",
year = "2014",
abstract = "Background/Aim. Obstructive sleep apnea (OSA) is one of the most prevalent sleep disorders. It is recognized as a serious risk factor for car and workplace accidents due to daytime sleepiness, and factor for coronary heart diseases and stroke. The aim of this study was to examine the effectiveness of oral appliances for mandibular advance in treating mild to moderate OSA. Methods. A total of 15 patients were included in this study, all diagnosed with mild or moderate OSA. Oral appliances were custom made for each patient in protrusive position at 50% of maximum mandibular advancement. The patients were given instructions not to sleep on their backs and avoid alcohol consumption during the study as these are the factors that can contribute to symptoms progression. Results. Complete and partial treatment success was achieve in 14 of the patients. Apnea-hypopnea index values were significantly lower (p  lt  0.05) at the end of a 6-month observation period compared to those at the treatment beginning. A great improvement in symptoms was observed, with daytime sleepiness index values significantly reduced already within the first month of the treatment. Conclusion. Treatment of obstructive sleep apnea with oral appliances has proven successful. Patients were comfortable using oral appliances and were ready to wear them for prolonged period of time. Use of oral appliances is very common in the world and should not be discarded. They are also very comfortable, practical and affordable comparing to continuous positive airway pressure (CPAP) apparatus, not to mention surgery. Use of oral appliances is safe and very well tolerated, and ought to be offered to patients with OSA., Uvod/Cilj. Opstruktivna apneja u snu je jedan od najčešćih poremećaja spavanja. Dokazano je da su bolesnici koji pate od ovog poremećaja skloniji saobraćajnim nezgodama i povredama na radu, kao i da su izloženi većem riziku od nastanka koronarne bolesti srca i moždanog udara. Cilj ovog istraživanja bio je da se utvrdi uspešnost terapije blage i umerene opstruktivne apneje u snu oralnim aparatima. Metode. Ukupno 15 bolesnika sa prethodno uspostavljenom dijagnozom blage ili umerene opstruktivne apneje u snu bilo je uključeno u istraživanje. Oralni aparati su individualno urađeni za svakog bolesnika, sa mandibulom u protruzionom položaju 50% od maksimalnog. Bolesnicima je preporučeno da izbegavaju spavanje na leđima i unošenje alkohola tokom trajanja studije, jer ovi faktori mogu uticati na pogoršanje simptoma. Rezultati. Potpuni i delimični uspeh terapije postignut je kod 14 bolesnika. Vrednosti apneja-hipopneja indeksa bile su statistički značajno niže (p  lt  0,05) od početnih vrednosti na kraju 6-mesečnog perioda posmatranja. Registrovano je i značajno poboljšanje simptoma, kao i značajno umanjenje vretnosti indeksa dnevne pospanosti već posle prvog meseca terapije. Zaključak. Oralni aparati su bili uspešni u lečenju opstruktivne apneje u snu. Bolesnici su iskazali veliku lagodnost i bili su spremni da nose oralne aparate i duži vremenski period. Upotreba oralnih aparata je uobičajena u svetu, i ne treba da bude zanemarena. Vrlo su praktični, lagodni za nošenje i pristupačniji u poređenju sa aparatom za kontinuirani pozitivni pritisak u disajnim putevima (CPAP), a pogotovo sa hirurškom intervencijom. Upotreba oralnih aparata je bezbedna i trebalo bi je ponuditi bolesnicima kao jedno od mogućih rešenja.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Treatment of obstructive sleep apnea patients using oral appliances: Our experiences, Lečenje opstruktivne apneje u snu pomoću oralnih aparata - naša iskustva",
volume = "71",
number = "7",
pages = "623-626",
doi = "10.2298/VSP121129010M"
}

Miljuš, D., Tihaček-Šojić, L., Milić-Lemić, A.,& Anđelković, M.. (2014). Treatment of obstructive sleep apnea patients using oral appliances: Our experiences. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(7), 623-626.
https://doi.org/10.2298/VSP121129010M

Miljuš D, Tihaček-Šojić L, Milić-Lemić A, Anđelković M. Treatment of obstructive sleep apnea patients using oral appliances: Our experiences. in Vojnosanitetski pregled. 2014;71(7):623-626.
doi:10.2298/VSP121129010M .

Miljuš, Dušan, Tihaček-Šojić, Ljiljana, Milić-Lemić, Aleksandra, Anđelković, Marko, "Treatment of obstructive sleep apnea patients using oral appliances: Our experiences" in Vojnosanitetski pregled, 71, no. 7 (2014):623-626,
https://doi.org/10.2298/VSP121129010M . .

TY  - JOUR
AU  - Tihaček-Šojić, Ljiljana
AU  - Anđelković, Marko
AU  - Milić-Lemić, Aleksandra
AU  - Milošević, B.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1766
AB  - Obstructive sleep apnoea (OSA) is one of the most common sleep disorders in elderly and represents a special problem for elderly patients. Elderly patients use a large number of drugs that might have an influence on the upper airway structure, anxiolytics or benzodiazepines being the most common. The aim of this study was to examine the effectiveness of mild or moderate OSA treatment with mandibular advance oral appliance in older lorazepam users compared with the age-matched lorazepam-free patients. A total of 40 functionally independent patients with the age of 6574 were enrolled in the study. All included patients were found to suffer from at least two of the existing OSA symptoms (snoring, sleep fragmentation, daytime sleepiness) and were diagnosed with mild or moderate OSA after nocturnal polysomnography. Patients were divided into two groups. The experimental group consisted of 20 patients who used lorazepam in their daily therapy, and a control group consisted of 20 patients who did not take lorazepam. A mandibular advance appliance was made individually for each patient. Patients involved in the study were not overweight and were suggested to practise sleeping on the side and reduce alcohol consumption during the study. The study has shown that mandibular advance oral appliances were responsible for complete control of the OSA in over 37% of cases (15 patients). Patients have also reported substantial improvement in the symptoms; 80% of them reported that they had snored less, slept better (94%) and have not experienced daytime sleepiness (100%).
PB  - Wiley, Hoboken
T2  - Journal of Oral Rehabilitation
T1  - The effectiveness of oral appliances in elderly patients with obstructive sleep apnoea treated with lorazepam - a pilot study
VL  - 39
IS  - 10
SP  - 785
EP  - 790
DO  - 10.1111/j.1365-2842.2012.02324.x
ER  - 

@article{
author = "Tihaček-Šojić, Ljiljana and Anđelković, Marko and Milić-Lemić, Aleksandra and Milošević, B.",
year = "2012",
abstract = "Obstructive sleep apnoea (OSA) is one of the most common sleep disorders in elderly and represents a special problem for elderly patients. Elderly patients use a large number of drugs that might have an influence on the upper airway structure, anxiolytics or benzodiazepines being the most common. The aim of this study was to examine the effectiveness of mild or moderate OSA treatment with mandibular advance oral appliance in older lorazepam users compared with the age-matched lorazepam-free patients. A total of 40 functionally independent patients with the age of 6574 were enrolled in the study. All included patients were found to suffer from at least two of the existing OSA symptoms (snoring, sleep fragmentation, daytime sleepiness) and were diagnosed with mild or moderate OSA after nocturnal polysomnography. Patients were divided into two groups. The experimental group consisted of 20 patients who used lorazepam in their daily therapy, and a control group consisted of 20 patients who did not take lorazepam. A mandibular advance appliance was made individually for each patient. Patients involved in the study were not overweight and were suggested to practise sleeping on the side and reduce alcohol consumption during the study. The study has shown that mandibular advance oral appliances were responsible for complete control of the OSA in over 37% of cases (15 patients). Patients have also reported substantial improvement in the symptoms; 80% of them reported that they had snored less, slept better (94%) and have not experienced daytime sleepiness (100%).",
publisher = "Wiley, Hoboken",
journal = "Journal of Oral Rehabilitation",
title = "The effectiveness of oral appliances in elderly patients with obstructive sleep apnoea treated with lorazepam - a pilot study",
volume = "39",
number = "10",
pages = "785-790",
doi = "10.1111/j.1365-2842.2012.02324.x"
}

Tihaček-Šojić, L., Anđelković, M., Milić-Lemić, A.,& Milošević, B.. (2012). The effectiveness of oral appliances in elderly patients with obstructive sleep apnoea treated with lorazepam - a pilot study. in Journal of Oral Rehabilitation
Wiley, Hoboken., 39(10), 785-790.
https://doi.org/10.1111/j.1365-2842.2012.02324.x

Tihaček-Šojić L, Anđelković M, Milić-Lemić A, Milošević B. The effectiveness of oral appliances in elderly patients with obstructive sleep apnoea treated with lorazepam - a pilot study. in Journal of Oral Rehabilitation. 2012;39(10):785-790.
doi:10.1111/j.1365-2842.2012.02324.x .

Tihaček-Šojić, Ljiljana, Anđelković, Marko, Milić-Lemić, Aleksandra, Milošević, B., "The effectiveness of oral appliances in elderly patients with obstructive sleep apnoea treated with lorazepam - a pilot study" in Journal of Oral Rehabilitation, 39, no. 10 (2012):785-790,
https://doi.org/10.1111/j.1365-2842.2012.02324.x . .