TY  - JOUR
AU  - Zarić, S.
AU  - Bojić, B.
AU  - Popović, B.
AU  - Milašin, Jelena
PY  - 2015
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2017
AB  - Background: The influence of gastric Helicobacter pylori infection on the development of oral pathoses remains unclear. The aim of this study is to examine the influence of gastric H. pylori infection on occurrence of halitosis and coated tongue. Materials and methods: Ninety-eight patients with dyspepsia were included in the study and their salivary samples and gastric biopsies were analyzed for the presence of H. pylori by Nested-PCR. Halitosis and coated tongue were assessed at the initial examination and 3 months after systemic eradication therapy against H. pylori. Results: Gastric biopsies of 66 patients were positive for H. pylori. Only one saliva sample was H. pylori positive. At initial examination, halitosis was observed in 20 patients (30.3%) out of 66 who had gastric H. pylori infection and in only 3 patients (9.4%) out of 32 without H. pylori infection (p = 0.0236). Coated tongue was diagnosed in 18 (27.2%) patients with the infection compared to only 2 (6.25%) patients negative for gastric H. pylori (p = 0.0164). Patients with gastric infection were treated with the triple eradication therapy (Amoxicillin, Clarythromycin, Pantoprazol) and their gastric biopsies and oral status were examined 3 months later. Halitosis was significantly more prevalent in the group of patients with persistent H. pylori infection (42.1%) compared to only 6.4% of patients in the group where infection was successfully eradicated (p = 0.0012). Coated tongue was diagnosed in 47.4% of patients where H. pylori was still present after eradication therapy and in only 6.4% where eradication succeeded (p = 0.0003). Conclusion: Our findings suggest that eradication of gastric H. pylori significantly alleviates halitosis and coated tongue, the two oral conditions that may be considered as extragastric manifestations of this common chronic bacterial infection.
PB  - Jaypee Brothers Medical Publishers (P) Ltd
T2  - Journal of Contemporary Dental Practice
T1  - Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating
VL  - 16
IS  - 3
SP  - 205
EP  - 209
DO  - 10.5005/jp-journals-10024-1662
ER  - 

@article{
author = "Zarić, S. and Bojić, B. and Popović, B. and Milašin, Jelena",
year = "2015",
abstract = "Background: The influence of gastric Helicobacter pylori infection on the development of oral pathoses remains unclear. The aim of this study is to examine the influence of gastric H. pylori infection on occurrence of halitosis and coated tongue. Materials and methods: Ninety-eight patients with dyspepsia were included in the study and their salivary samples and gastric biopsies were analyzed for the presence of H. pylori by Nested-PCR. Halitosis and coated tongue were assessed at the initial examination and 3 months after systemic eradication therapy against H. pylori. Results: Gastric biopsies of 66 patients were positive for H. pylori. Only one saliva sample was H. pylori positive. At initial examination, halitosis was observed in 20 patients (30.3%) out of 66 who had gastric H. pylori infection and in only 3 patients (9.4%) out of 32 without H. pylori infection (p = 0.0236). Coated tongue was diagnosed in 18 (27.2%) patients with the infection compared to only 2 (6.25%) patients negative for gastric H. pylori (p = 0.0164). Patients with gastric infection were treated with the triple eradication therapy (Amoxicillin, Clarythromycin, Pantoprazol) and their gastric biopsies and oral status were examined 3 months later. Halitosis was significantly more prevalent in the group of patients with persistent H. pylori infection (42.1%) compared to only 6.4% of patients in the group where infection was successfully eradicated (p = 0.0012). Coated tongue was diagnosed in 47.4% of patients where H. pylori was still present after eradication therapy and in only 6.4% where eradication succeeded (p = 0.0003). Conclusion: Our findings suggest that eradication of gastric H. pylori significantly alleviates halitosis and coated tongue, the two oral conditions that may be considered as extragastric manifestations of this common chronic bacterial infection.",
publisher = "Jaypee Brothers Medical Publishers (P) Ltd",
journal = "Journal of Contemporary Dental Practice",
title = "Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating",
volume = "16",
number = "3",
pages = "205-209",
doi = "10.5005/jp-journals-10024-1662"
}

Zarić, S., Bojić, B., Popović, B.,& Milašin, J.. (2015). Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating. in Journal of Contemporary Dental Practice
Jaypee Brothers Medical Publishers (P) Ltd., 16(3), 205-209.
https://doi.org/10.5005/jp-journals-10024-1662

Zarić S, Bojić B, Popović B, Milašin J. Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating. in Journal of Contemporary Dental Practice. 2015;16(3):205-209.
doi:10.5005/jp-journals-10024-1662 .

Zarić, S., Bojić, B., Popović, B., Milašin, Jelena, "Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating" in Journal of Contemporary Dental Practice, 16, no. 3 (2015):205-209,
https://doi.org/10.5005/jp-journals-10024-1662 . .

TY  - JOUR
AU  - Zarić, S.
AU  - Bojić, B.
AU  - Janković, Ljiljana
AU  - Dapčević, B.
AU  - Popović, Branka
AU  - Čakić, Saša
AU  - Milašin, Jelena
PY  - 2009
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1501
AB  - The oral cavity has been proposed as a reservoir for H. pylori that could be responsible for the refractoriness of gastric infection to triple therapy (antibiotics, antimicrobials, and proton pump inhibitors). The aim of this study was to evaluate the efficiency of combined periodontal and triple therapy vs. triple therapy alone, in gastric H. pylori eradication in persons with H. pylori in the subgingival biofilm. Individuals positive for H. pylori in their gastric and oral samples, as determined by nested PCR, were treated either with periodontal and triple therapy or with triple therapy alone. Our results indicate that 77.3% of those treated with the combined therapy exhibited successful eradication of gastric H. pylori, compared with 47.6% who underwent only triple therapy. Analysis of these data suggests that periodontal treatment in combination with systemic therapy could be a promising approach to increasing the therapy's efficacy and decreasing the risk of infection recurrence.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Journal of Dental Research
T1  - Periodontal Therapy Improves Gastric Helicobacter pylori Eradication
VL  - 88
IS  - 10
SP  - 946
EP  - 950
DO  - 10.1177/0022034509344559
ER  - 

@article{
author = "Zarić, S. and Bojić, B. and Janković, Ljiljana and Dapčević, B. and Popović, Branka and Čakić, Saša and Milašin, Jelena",
year = "2009",
abstract = "The oral cavity has been proposed as a reservoir for H. pylori that could be responsible for the refractoriness of gastric infection to triple therapy (antibiotics, antimicrobials, and proton pump inhibitors). The aim of this study was to evaluate the efficiency of combined periodontal and triple therapy vs. triple therapy alone, in gastric H. pylori eradication in persons with H. pylori in the subgingival biofilm. Individuals positive for H. pylori in their gastric and oral samples, as determined by nested PCR, were treated either with periodontal and triple therapy or with triple therapy alone. Our results indicate that 77.3% of those treated with the combined therapy exhibited successful eradication of gastric H. pylori, compared with 47.6% who underwent only triple therapy. Analysis of these data suggests that periodontal treatment in combination with systemic therapy could be a promising approach to increasing the therapy's efficacy and decreasing the risk of infection recurrence.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Journal of Dental Research",
title = "Periodontal Therapy Improves Gastric Helicobacter pylori Eradication",
volume = "88",
number = "10",
pages = "946-950",
doi = "10.1177/0022034509344559"
}

Zarić, S., Bojić, B., Janković, L., Dapčević, B., Popović, B., Čakić, S.,& Milašin, J.. (2009). Periodontal Therapy Improves Gastric Helicobacter pylori Eradication. in Journal of Dental Research
Sage Publications Inc, Thousand Oaks., 88(10), 946-950.
https://doi.org/10.1177/0022034509344559

Zarić S, Bojić B, Janković L, Dapčević B, Popović B, Čakić S, Milašin J. Periodontal Therapy Improves Gastric Helicobacter pylori Eradication. in Journal of Dental Research. 2009;88(10):946-950.
doi:10.1177/0022034509344559 .

Zarić, S., Bojić, B., Janković, Ljiljana, Dapčević, B., Popović, Branka, Čakić, Saša, Milašin, Jelena, "Periodontal Therapy Improves Gastric Helicobacter pylori Eradication" in Journal of Dental Research, 88, no. 10 (2009):946-950,
https://doi.org/10.1177/0022034509344559 . .