TY  - JOUR
AU  - Ašćerić, Radislav
AU  - Dimković, Nada
AU  - Trajković, Goran Z.
AU  - Ristić, Biljana S.
AU  - Janković, Aleksandar N.
AU  - Đurić, Petar
AU  - Ilijevski, Nenad S.
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2410
AB  - BackgroundPeripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD and its risk factors in patients on hemodialysis.MethodsThis cross-sectional study included 156 hemodialysis patients. Comorbidities and laboratory parameters were analyzed. Following clinical examinations, the ankle-brachial index was measured in all patients. PAD was diagnosed based on the clinical findings, ankle-brachial index  lt 0.9, and PAD symptoms.ResultsPAD was present in 55 of 156 (35.3%; 95% CI, 27.7-42.8%) patients. The patients with PAD were significantly older (6710years vs. 62 +/- 11years, p=0.014), more likely to have diabetes mellitus (p=0.022), and anemia (p=0.042), and had significantly lower serum albumin (p=0.005), total cholesterol (p=0.024), and iron (p=0.004) levels, higher glucose (p=0.002) and C-reactive protein (p lt 0.001) levels, and lower dialysis adequacies (p=0.040) than the patients without PAD. Multivariate analysis showed higher C-reactive protein level (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.06; p=0.030), vascular access by Hickman catheter (OR, 4.66; 95% CI, 1.03-21.0; p=0.045), and symptoms of PAD (OR, 5.20; 95% CI, 2.60-10.4; p lt 0.001) as independent factors associated with PAD in hemodialysis patients.ConclusionThe prevalence of PAD was high among patients with end-stage renal disease on hemodialysis. Symptoms of PAD, higher C-reactive protein levels, and Hickman vascular access were independent predictors of PAD in patients on hemodialysis.
PB  - BMC, LONDON
T2  - BMC Nephrology
T1  - Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study
VL  - 20
DO  - 10.1186/s12882-019-1468-x
ER  - 

@article{
author = "Ašćerić, Radislav and Dimković, Nada and Trajković, Goran Z. and Ristić, Biljana S. and Janković, Aleksandar N. and Đurić, Petar and Ilijevski, Nenad S.",
year = "2019",
abstract = "BackgroundPeripheral arterial disease (PAD) is common in patients with end-stage renal disease on hemodialysis, but is frequently underdiagnosed. The risk factors for PAD are well known within the general population, but they differ somewhat in hemodialysis patients. This study aimed to determine the prevalence of PAD and its risk factors in patients on hemodialysis.MethodsThis cross-sectional study included 156 hemodialysis patients. Comorbidities and laboratory parameters were analyzed. Following clinical examinations, the ankle-brachial index was measured in all patients. PAD was diagnosed based on the clinical findings, ankle-brachial index  lt 0.9, and PAD symptoms.ResultsPAD was present in 55 of 156 (35.3%; 95% CI, 27.7-42.8%) patients. The patients with PAD were significantly older (6710years vs. 62 +/- 11years, p=0.014), more likely to have diabetes mellitus (p=0.022), and anemia (p=0.042), and had significantly lower serum albumin (p=0.005), total cholesterol (p=0.024), and iron (p=0.004) levels, higher glucose (p=0.002) and C-reactive protein (p lt 0.001) levels, and lower dialysis adequacies (p=0.040) than the patients without PAD. Multivariate analysis showed higher C-reactive protein level (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.00-1.06; p=0.030), vascular access by Hickman catheter (OR, 4.66; 95% CI, 1.03-21.0; p=0.045), and symptoms of PAD (OR, 5.20; 95% CI, 2.60-10.4; p lt 0.001) as independent factors associated with PAD in hemodialysis patients.ConclusionThe prevalence of PAD was high among patients with end-stage renal disease on hemodialysis. Symptoms of PAD, higher C-reactive protein levels, and Hickman vascular access were independent predictors of PAD in patients on hemodialysis.",
publisher = "BMC, LONDON",
journal = "BMC Nephrology",
title = "Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study",
volume = "20",
doi = "10.1186/s12882-019-1468-x"
}

Ašćerić, R., Dimković, N., Trajković, G. Z., Ristić, B. S., Janković, A. N., Đurić, P.,& Ilijevski, N. S.. (2019). Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study. in BMC Nephrology
BMC, LONDON., 20.
https://doi.org/10.1186/s12882-019-1468-x

Ašćerić R, Dimković N, Trajković GZ, Ristić BS, Janković AN, Đurić P, Ilijevski NS. Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study. in BMC Nephrology. 2019;20.
doi:10.1186/s12882-019-1468-x .

Ašćerić, Radislav, Dimković, Nada, Trajković, Goran Z., Ristić, Biljana S., Janković, Aleksandar N., Đurić, Petar, Ilijevski, Nenad S., "Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: a cross-sectional study" in BMC Nephrology, 20 (2019),
https://doi.org/10.1186/s12882-019-1468-x . .

TY  - JOUR
AU  - Scepanović, M. S.
AU  - Kovačević, Bojan
AU  - Cijan, V.
AU  - Antić, A.
AU  - Petrović, Z.
AU  - Ašćerić, Radislav
AU  - Krdzić, I.
AU  - Ćuk, Vladimir
PY  - 2013
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1775
AB  - Background Anastomotic leakage (AL) represents a serious complication after abdominal surgery. Therefore, it is important to detect it early before it becomes clinically apparent. The predictive value of C-reactive protein (CRP) as a marker of infective postoperative complications, particularly in the form of anastomotic leakage, has been investigated by several authors with promising results. The aim of this study was to evaluate the diagnostic accuracy of C-reactive protein in predicting anastomotic leakage. The serum CRP level, white blood cell (WBC) count, and body temperature (BT) of 156 patients who underwent elective abdominal surgery with primary anastomosis were monitored daily until postoperative day (POD) 7. We recorded all postoperative complications and analyzed the data. Diagnostic accuracy of CRP with regard to development of AL was assessed by receiver operating characteristic curve analysis. Fifteen patients (9.6 %) developed anastomotic leakage. CRP was significantly higher every day during the first 7 postoperative days in patients who developed AL compared with those patients who did not develop complications, whereas the WBC count and BT were not. A CRP cutoff value of 135 mg/l on POD 3 yielded a sensitivity of 73 %, a specificity of 73 %, and a negative predictive value of 95.4 % for the detection of AL. According to our results, values of CRP less than 135 mg/l on POD 3 may contribute to a safe discharge from hospital. Patients with CRP values higher than 135 mg/l on POD 3 require prolonged hospitalization and an intensive search for infective complications, particularly AL.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Techniques in Coloproctology
T1  - C-reactive protein as an early predictor for anastomotic leakage in elective abdominal surgery
VL  - 17
IS  - 5
SP  - 541
EP  - 547
DO  - 10.1007/s10151-013-1013-z
ER  - 

@article{
author = "Scepanović, M. S. and Kovačević, Bojan and Cijan, V. and Antić, A. and Petrović, Z. and Ašćerić, Radislav and Krdzić, I. and Ćuk, Vladimir",
year = "2013",
abstract = "Background Anastomotic leakage (AL) represents a serious complication after abdominal surgery. Therefore, it is important to detect it early before it becomes clinically apparent. The predictive value of C-reactive protein (CRP) as a marker of infective postoperative complications, particularly in the form of anastomotic leakage, has been investigated by several authors with promising results. The aim of this study was to evaluate the diagnostic accuracy of C-reactive protein in predicting anastomotic leakage. The serum CRP level, white blood cell (WBC) count, and body temperature (BT) of 156 patients who underwent elective abdominal surgery with primary anastomosis were monitored daily until postoperative day (POD) 7. We recorded all postoperative complications and analyzed the data. Diagnostic accuracy of CRP with regard to development of AL was assessed by receiver operating characteristic curve analysis. Fifteen patients (9.6 %) developed anastomotic leakage. CRP was significantly higher every day during the first 7 postoperative days in patients who developed AL compared with those patients who did not develop complications, whereas the WBC count and BT were not. A CRP cutoff value of 135 mg/l on POD 3 yielded a sensitivity of 73 %, a specificity of 73 %, and a negative predictive value of 95.4 % for the detection of AL. According to our results, values of CRP less than 135 mg/l on POD 3 may contribute to a safe discharge from hospital. Patients with CRP values higher than 135 mg/l on POD 3 require prolonged hospitalization and an intensive search for infective complications, particularly AL.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Techniques in Coloproctology",
title = "C-reactive protein as an early predictor for anastomotic leakage in elective abdominal surgery",
volume = "17",
number = "5",
pages = "541-547",
doi = "10.1007/s10151-013-1013-z"
}

Scepanović, M. S., Kovačević, B., Cijan, V., Antić, A., Petrović, Z., Ašćerić, R., Krdzić, I.,& Ćuk, V.. (2013). C-reactive protein as an early predictor for anastomotic leakage in elective abdominal surgery. in Techniques in Coloproctology
Springer-Verlag Italia Srl, Milan., 17(5), 541-547.
https://doi.org/10.1007/s10151-013-1013-z

Scepanović MS, Kovačević B, Cijan V, Antić A, Petrović Z, Ašćerić R, Krdzić I, Ćuk V. C-reactive protein as an early predictor for anastomotic leakage in elective abdominal surgery. in Techniques in Coloproctology. 2013;17(5):541-547.
doi:10.1007/s10151-013-1013-z .

Scepanović, M. S., Kovačević, Bojan, Cijan, V., Antić, A., Petrović, Z., Ašćerić, Radislav, Krdzić, I., Ćuk, Vladimir, "C-reactive protein as an early predictor for anastomotic leakage in elective abdominal surgery" in Techniques in Coloproctology, 17, no. 5 (2013):541-547,
https://doi.org/10.1007/s10151-013-1013-z . .