TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Radojević-Škodrić, Sanja
AU  - Brašanac, Dimitrije
AU  - Đuricić, S.
AU  - Milašin, Jelena
AU  - Bogdanović, L.
AU  - Oprić, D.
AU  - Savin, M.
AU  - Baralić, I.
AU  - Jovanović, M.
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1747
AB  - Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Prognostic value of survivin expression in Wilms tumor
VL  - 17
IS  - 1
SP  - 168
EP  - 173
UR  - https://hdl.handle.net/21.15107/rcub_smile_1747
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Radojević-Škodrić, Sanja and Brašanac, Dimitrije and Đuricić, S. and Milašin, Jelena and Bogdanović, L. and Oprić, D. and Savin, M. and Baralić, I. and Jovanović, M.",
year = "2012",
abstract = "Purpose: To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage. Methods: Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor. Results: 51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1). Conclusion: Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Prognostic value of survivin expression in Wilms tumor",
volume = "17",
number = "1",
pages = "168-173",
url = "https://hdl.handle.net/21.15107/rcub_smile_1747"
}

Basta-Jovanović, G., Radojević-Škodrić, S., Brašanac, D., Đuricić, S., Milašin, J., Bogdanović, L., Oprić, D., Savin, M., Baralić, I.,& Jovanović, M.. (2012). Prognostic value of survivin expression in Wilms tumor. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 17(1), 168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747

Basta-Jovanović G, Radojević-Škodrić S, Brašanac D, Đuricić S, Milašin J, Bogdanović L, Oprić D, Savin M, Baralić I, Jovanović M. Prognostic value of survivin expression in Wilms tumor. in Journal of BUON. 2012;17(1):168-173.
https://hdl.handle.net/21.15107/rcub_smile_1747 .

Basta-Jovanović, Gordana, Radojević-Škodrić, Sanja, Brašanac, Dimitrije, Đuricić, S., Milašin, Jelena, Bogdanović, L., Oprić, D., Savin, M., Baralić, I., Jovanović, M., "Prognostic value of survivin expression in Wilms tumor" in Journal of BUON, 17, no. 1 (2012):168-173,
https://hdl.handle.net/21.15107/rcub_smile_1747 .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Suzić, S.
AU  - Savin, M.
AU  - Petronijević, Nataša
AU  - Radonjić, N.
AU  - Signuričić, S.
AU  - Vučković, Mila
AU  - Radojević-Škodrić, Sanja
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1408
AB  - Proliferative disorders including tumors are recognized as diseases of the cell cycle in which the crucial role belongs to the cyclin-dependent kinase family. The aim of this study was to investigate the expression of protein p16 in the normal kidney, and in Wilms tumor by immunohistochemistry to correlate the obtained results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/III, showing no statistically significant correlation (p > 0.05). Intermediate risk groups of Wilms tumor showed more frequent p16 expression in comparison with high risk cases, showing no statistical significance (p > 0.05). Protein p16 expression was detected in all histologic types of Wilms tumor with the highest expression in the predominantly blastemal type (50%). There was a statistically significant difference between p16 expression in this and its expression in other histological types (p  lt  0.05). The correlation between p16 expression and the predominantly blastemal histological type was statistically significant and showed that in such cases tumor cells can proliferate even in the presence of p16.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta Veterinaria
T1  - Immunohistochemical expression of protein p16 in Wilms' tumor
VL  - 58
IS  - 4
SP  - 297
EP  - 306
DO  - 10.2298/AVB0804297B
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Suzić, S. and Savin, M. and Petronijević, Nataša and Radonjić, N. and Signuričić, S. and Vučković, Mila and Radojević-Škodrić, Sanja",
year = "2008",
abstract = "Proliferative disorders including tumors are recognized as diseases of the cell cycle in which the crucial role belongs to the cyclin-dependent kinase family. The aim of this study was to investigate the expression of protein p16 in the normal kidney, and in Wilms tumor by immunohistochemistry to correlate the obtained results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/III, showing no statistically significant correlation (p > 0.05). Intermediate risk groups of Wilms tumor showed more frequent p16 expression in comparison with high risk cases, showing no statistical significance (p > 0.05). Protein p16 expression was detected in all histologic types of Wilms tumor with the highest expression in the predominantly blastemal type (50%). There was a statistically significant difference between p16 expression in this and its expression in other histological types (p  lt  0.05). The correlation between p16 expression and the predominantly blastemal histological type was statistically significant and showed that in such cases tumor cells can proliferate even in the presence of p16.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta Veterinaria",
title = "Immunohistochemical expression of protein p16 in Wilms' tumor",
volume = "58",
number = "4",
pages = "297-306",
doi = "10.2298/AVB0804297B"
}

Basta-Jovanović, G., Suzić, S., Savin, M., Petronijević, N., Radonjić, N., Signuričić, S., Vučković, M.,& Radojević-Škodrić, S.. (2008). Immunohistochemical expression of protein p16 in Wilms' tumor. in Acta Veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 58(4), 297-306.
https://doi.org/10.2298/AVB0804297B

Basta-Jovanović G, Suzić S, Savin M, Petronijević N, Radonjić N, Signuričić S, Vučković M, Radojević-Škodrić S. Immunohistochemical expression of protein p16 in Wilms' tumor. in Acta Veterinaria. 2008;58(4):297-306.
doi:10.2298/AVB0804297B .

Basta-Jovanović, Gordana, Suzić, S., Savin, M., Petronijević, Nataša, Radonjić, N., Signuričić, S., Vučković, Mila, Radojević-Škodrić, Sanja, "Immunohistochemical expression of protein p16 in Wilms' tumor" in Acta Veterinaria, 58, no. 4 (2008):297-306,
https://doi.org/10.2298/AVB0804297B . .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, L.
AU  - Jovanović, M.
AU  - Baralić, I.
AU  - Savin, M.
AU  - Basta-Jovanović, Gordana
PY  - 2008
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1392
AB  - INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Polycystic kidney disease--autopsy review from the period 1987-2007
VL  - 136 Suppl 4
SP  - 294
EP  - 297
DO  - 10.2298/SARH08S4294R
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Bogdanović, L. and Jovanović, M. and Baralić, I. and Savin, M. and Basta-Jovanović, Gordana",
year = "2008",
abstract = "INTRODUCTION: Polycystic kidney disease is an inherited kidney disease that affects both kidneys and it is characterized by diffuse replacement of renal parenchyma by thousands of microcysts. In time, renal insufficiency develops. There are two forms of PKD: ADPKD, which is detected in adults (children are rarely affected), and ARPK, which is detected in neonates (later presentations do occur, but rarely). OBJECTIVE: The aim of this study was to analyse frequency of polycystic kidney disease, clinical data and morphological characteristics. METHOD: At the Institute of Pathology, School of Medicine, Belgrade, there were detected 33 cases of ADPKD and 20 cases of ARPKD between 1987 and 2007. RESULTS: There were no differences between incidence of ADPKD in males and females. Average age of patients with ADPKD was 52 years. In 20 (66.7%) cases of ADPKD there were neither extrarenal cysts nor extrarenal manifestations detected. In other 13 cases, we detected extrarenal cysts: hepatic cysts in 8 cases, pancreatic cysts in 5 cases. In two cases, hepatic cysts were associated with intracranial (arachnoid cysts) and extracranial aneurysms. The most frequent cause of death in patients with ADPKD was end-stage disease. ARPKD affects more often male children compared to female. 70% of children with ARPKD were male. The mean age of patients with ARPKD was 1 month. 5 patients (40%) had hepatic fibrosis. The most frequent cause of death was respiratory insufficiency (75%). In 25% of patients, the cause of death was sepsis and renal insufficiency. CONCLUSION: Morphological and clinical manifestations of the analysed cases of both types of PKD are fairly consistent with literature data. Better knowing of aethiopathogenesis of PKD will facilitate early diagnosis, based on clinical and morphological characteristics and better management of the disease.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Polycystic kidney disease--autopsy review from the period 1987-2007",
volume = "136 Suppl 4",
pages = "294-297",
doi = "10.2298/SARH08S4294R"
}

Radojević-Škodrić, S., Bogdanović, L., Jovanović, M., Baralić, I., Savin, M.,& Basta-Jovanović, G.. (2008). Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 136 Suppl 4, 294-297.
https://doi.org/10.2298/SARH08S4294R

Radojević-Škodrić S, Bogdanović L, Jovanović M, Baralić I, Savin M, Basta-Jovanović G. Polycystic kidney disease--autopsy review from the period 1987-2007. in Srpski arhiv za celokupno lekarstvo. 2008;136 Suppl 4:294-297.
doi:10.2298/SARH08S4294R .

Radojević-Škodrić, Sanja, Bogdanović, L., Jovanović, M., Baralić, I., Savin, M., Basta-Jovanović, Gordana, "Polycystic kidney disease--autopsy review from the period 1987-2007" in Srpski arhiv za celokupno lekarstvo, 136 Suppl 4 (2008):294-297,
https://doi.org/10.2298/SARH08S4294R . .