TY  - JOUR
AU  - Ilić-Živojinović, Jelena B.
AU  - Ilić, Branislav
AU  - Backović, Dušan
AU  - Tomanić, Milena
AU  - Gavrilović, Aleksandar
AU  - Bogdanović, Ljiljana
PY  - 2019
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2428
AB  - Introduction/Objective Knowledge and practical skills in medical waste (MW) management are of equal importance for medical and dental doctors. The first comparative study on the knowledge and skills in the field of MW management among Belgrade students was conducted with the goal of examining whether students of medicine and dentistry are equally familiar with this extremely important field. Methods a cross-sectional study included 558 students of the sixth year of studies (430 medical and 128 dental students) who completed an anonymous semi-structured questionnaire to determine attitudes and knowledge on MW management. Results the majority of medical and dental students had no training in MW management (79.5% and 74.6%, respectively). Dental students use protective equipment more frequently than medical students (94.5% vs. 42%, p  lt  0.001). However, full vaccinal protection against hepatitis B is better among medical students compared to dental students (57.7% vs. 39.1%, p  lt  0.001). Complete knowledge on postexposal prophylaxis is better among medical students compared to dental students (44.5% vs. 13.3%, p  lt  0.001). However, dental students are more disciplined in reporting injuries (63.1% vs. 52.4%, p = 0.038). The students' knowledge on primary separation of infectious waste (93% vs. 77.8%, p  lt  0.001) and used needles (80.3% vs. 70.4%, p = 0.007) is better among dental students compared to medical students' correct answers. Conclusion Dental students show better knowledge on MW management and are more disciplined in using personal infection protection compared to medical students. The students support continued training on MW management and investigations on this topic.
AB  - Uvod/Cilj Znanje i praktične veštine upravljanja medicinskim otpadom su od posebnog značaja za doktore medicine i stomatologije. Komparativna studija o znanju i veštinama iz oblasti upravljanja medicinskim otpadom sprovedena je među beogradskim studentima prvi put, u cilju ispitivanja da li ovom izuzetno važnom oblašću studenti medicine i stomatologije vladaju podjednako dobro. Metode Ova studija preseka obuhvatila je 558 studenata šeste godine studija na Beogradskom univerzitetu (430 studenata medicine i 128 studenata stomatologije), koji su popunili anonimni upitnik o znanju i stavovima o upravljanju medicinskim otpadom. Rezultati Većina studenata stomatologije i medicine nisu imali nikakvu posebnu obuku iz upravljanja medicinskim otpadom (79,5% i 74,6%). Studenti stomatologije su češće koristili zaštitnu opremu (94,5% prema 42%, p  lt  0,001). Vakcinalna zaštita od hepatitisa B je kompletnija među studentima medicine u odnosu na studente stomatologije (57,7% prema 39,1%, p  lt  0,001). Znanje o profilaksi posle izloženosti bolja je među studentima medicine (44,5% prema 13,3%, p  lt  0,001). Međutim, studenti stomatologije su ažurniji u pogledu prijavljivanja povreda na radnom mestu (63,1% prema 52,4%, p = 0,038). Znanje studenata o primarnoj separaciji infektivnog otpada i korišćenih igala je bolje među budućim stomatolozima (tačni odgovori 93% nasuprot 77,8%; p  lt  0,001 i 80,3% prema 70,4%; p = 0,007). Zaključak Studenti stomatologije imaju bolje znanje o upravljanju medicinskim otpadom i disciplinovaniji su u pogledu korišćenja zaštitne opreme na radu u odnosu na studente medicine. Studenti podržavaju kontinuiranu edukaciju o upravljanju medicinskim otpadom i dalja istraživanja o ovoj temi.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Knowledge and attitudes on medical waste management among Belgrade medical and dental students
T1  - Znanje i stavovi beogradskih studenata medicine i stomatologije o upravljanju medicinskim otpadom
VL  - 147
IS  - 5-6
SP  - 281
EP  - 285
DO  - 10.2298/SARH180405065I
ER  - 

@article{
author = "Ilić-Živojinović, Jelena B. and Ilić, Branislav and Backović, Dušan and Tomanić, Milena and Gavrilović, Aleksandar and Bogdanović, Ljiljana",
year = "2019",
abstract = "Introduction/Objective Knowledge and practical skills in medical waste (MW) management are of equal importance for medical and dental doctors. The first comparative study on the knowledge and skills in the field of MW management among Belgrade students was conducted with the goal of examining whether students of medicine and dentistry are equally familiar with this extremely important field. Methods a cross-sectional study included 558 students of the sixth year of studies (430 medical and 128 dental students) who completed an anonymous semi-structured questionnaire to determine attitudes and knowledge on MW management. Results the majority of medical and dental students had no training in MW management (79.5% and 74.6%, respectively). Dental students use protective equipment more frequently than medical students (94.5% vs. 42%, p  lt  0.001). However, full vaccinal protection against hepatitis B is better among medical students compared to dental students (57.7% vs. 39.1%, p  lt  0.001). Complete knowledge on postexposal prophylaxis is better among medical students compared to dental students (44.5% vs. 13.3%, p  lt  0.001). However, dental students are more disciplined in reporting injuries (63.1% vs. 52.4%, p = 0.038). The students' knowledge on primary separation of infectious waste (93% vs. 77.8%, p  lt  0.001) and used needles (80.3% vs. 70.4%, p = 0.007) is better among dental students compared to medical students' correct answers. Conclusion Dental students show better knowledge on MW management and are more disciplined in using personal infection protection compared to medical students. The students support continued training on MW management and investigations on this topic., Uvod/Cilj Znanje i praktične veštine upravljanja medicinskim otpadom su od posebnog značaja za doktore medicine i stomatologije. Komparativna studija o znanju i veštinama iz oblasti upravljanja medicinskim otpadom sprovedena je među beogradskim studentima prvi put, u cilju ispitivanja da li ovom izuzetno važnom oblašću studenti medicine i stomatologije vladaju podjednako dobro. Metode Ova studija preseka obuhvatila je 558 studenata šeste godine studija na Beogradskom univerzitetu (430 studenata medicine i 128 studenata stomatologije), koji su popunili anonimni upitnik o znanju i stavovima o upravljanju medicinskim otpadom. Rezultati Većina studenata stomatologije i medicine nisu imali nikakvu posebnu obuku iz upravljanja medicinskim otpadom (79,5% i 74,6%). Studenti stomatologije su češće koristili zaštitnu opremu (94,5% prema 42%, p  lt  0,001). Vakcinalna zaštita od hepatitisa B je kompletnija među studentima medicine u odnosu na studente stomatologije (57,7% prema 39,1%, p  lt  0,001). Znanje o profilaksi posle izloženosti bolja je među studentima medicine (44,5% prema 13,3%, p  lt  0,001). Međutim, studenti stomatologije su ažurniji u pogledu prijavljivanja povreda na radnom mestu (63,1% prema 52,4%, p = 0,038). Znanje studenata o primarnoj separaciji infektivnog otpada i korišćenih igala je bolje među budućim stomatolozima (tačni odgovori 93% nasuprot 77,8%; p  lt  0,001 i 80,3% prema 70,4%; p = 0,007). Zaključak Studenti stomatologije imaju bolje znanje o upravljanju medicinskim otpadom i disciplinovaniji su u pogledu korišćenja zaštitne opreme na radu u odnosu na studente medicine. Studenti podržavaju kontinuiranu edukaciju o upravljanju medicinskim otpadom i dalja istraživanja o ovoj temi.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Knowledge and attitudes on medical waste management among Belgrade medical and dental students, Znanje i stavovi beogradskih studenata medicine i stomatologije o upravljanju medicinskim otpadom",
volume = "147",
number = "5-6",
pages = "281-285",
doi = "10.2298/SARH180405065I"
}

Ilić-Živojinović, J. B., Ilić, B., Backović, D., Tomanić, M., Gavrilović, A.,& Bogdanović, L.. (2019). Knowledge and attitudes on medical waste management among Belgrade medical and dental students. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 147(5-6), 281-285.
https://doi.org/10.2298/SARH180405065I

Ilić-Živojinović JB, Ilić B, Backović D, Tomanić M, Gavrilović A, Bogdanović L. Knowledge and attitudes on medical waste management among Belgrade medical and dental students. in Srpski arhiv za celokupno lekarstvo. 2019;147(5-6):281-285.
doi:10.2298/SARH180405065I .

Ilić-Živojinović, Jelena B., Ilić, Branislav, Backović, Dušan, Tomanić, Milena, Gavrilović, Aleksandar, Bogdanović, Ljiljana, "Knowledge and attitudes on medical waste management among Belgrade medical and dental students" in Srpski arhiv za celokupno lekarstvo, 147, no. 5-6 (2019):281-285,
https://doi.org/10.2298/SARH180405065I . .

TY  - JOUR
AU  - Bogdanović, Ljiljana
AU  - Lazić, Miodrag
AU  - Bogdanović, Jelena
AU  - Soldatović, Ivan
AU  - Nikolić, Nadja
AU  - Radunović, Milena
AU  - Radojević-Škodrić, Sanja
AU  - Milašin, Jelena
AU  - Basta-Jovanović, Gordana
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2182
AB  - Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population
VL  - 22
IS  - 1
SP  - 270
EP  - 277
UR  - https://hdl.handle.net/21.15107/rcub_smile_2182
ER  - 

@article{
author = "Bogdanović, Ljiljana and Lazić, Miodrag and Bogdanović, Jelena and Soldatović, Ivan and Nikolić, Nadja and Radunović, Milena and Radojević-Škodrić, Sanja and Milašin, Jelena and Basta-Jovanović, Gordana",
year = "2017",
abstract = "Purpose: Survivin is thought to play an important role in carcinogenesis and is found to be associated with poor clinical outcome in various malignancies. Gene-31 G/C polymorphism has been identified as a risk factor for the development of several types of tumors. The purpose of this study was to investigate the association between survivin gene promoter-31C/G polymorphism and urothelial carcinoma (UC) risk in Serbian population and to compare the different expressions of survivin in UC of different disease stages, histological grades and tumor location in the upper or lower urinary tract. Methods: DNA from 94 patients with primary UC and from 82 healthy subjects was subjected to PCR restriction fragment length polymorphism analysis (PCR-RFLP) to identify individual genotypes. UC samples were subjected to immunohistochemical analysis to assess survivin expression in these lesions. Results: It was observed that the frequency of G/G genotype was greater in patients with UC (58.7%) than in controls (32%). Compared with study subjects carrying the C/G or C/C genotypes, significantly increased UC risk was found for individuals carrying the G/G genotype. Those carrying the G/G genotype had a significantly increased UC risk compared with those with C/G or C/C genotypes. Patients with UC carrying the G/G genotype had a greater prevalence of muscle -invading (stage T2-T4), high-grade (G2) tumor and immunohistochemicaly overexpressed survivin compared with those carrying the C/G or C/C genotypes. Conclusions: G/G genotype of the -31C/G polymorphism might be a risk factor for UC development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population",
volume = "22",
number = "1",
pages = "270-277",
url = "https://hdl.handle.net/21.15107/rcub_smile_2182"
}

Bogdanović, L., Lazić, M., Bogdanović, J., Soldatović, I., Nikolić, N., Radunović, M., Radojević-Škodrić, S., Milašin, J.,& Basta-Jovanović, G.. (2017). Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(1), 270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182

Bogdanović L, Lazić M, Bogdanović J, Soldatović I, Nikolić N, Radunović M, Radojević-Škodrić S, Milašin J, Basta-Jovanović G. Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population. in Journal of BUON. 2017;22(1):270-277.
https://hdl.handle.net/21.15107/rcub_smile_2182 .

Bogdanović, Ljiljana, Lazić, Miodrag, Bogdanović, Jelena, Soldatović, Ivan, Nikolić, Nadja, Radunović, Milena, Radojević-Škodrić, Sanja, Milašin, Jelena, Basta-Jovanović, Gordana, "Polymorphisms of survivin-31 G/C gene are associated with risk of urothelial carcinoma in Serbian population" in Journal of BUON, 22, no. 1 (2017):270-277,
https://hdl.handle.net/21.15107/rcub_smile_2182 .

TY  - JOUR
AU  - Latić, Dragana
AU  - Radojević-Škodrić, Sanja
AU  - Nikolić, Srđan
AU  - Prvanović, Mirjana
AU  - Lazić, Miodrag
AU  - Džamić, Zoran
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Vuković, Marina
PY  - 2017
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2206
AB  - Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
VL  - 22
IS  - 5
SP  - 1322
EP  - 1327
UR  - https://hdl.handle.net/21.15107/rcub_smile_2206
ER  - 

@article{
author = "Latić, Dragana and Radojević-Škodrić, Sanja and Nikolić, Srđan and Prvanović, Mirjana and Lazić, Miodrag and Džamić, Zoran and Bogdanović, Ljiljana and Radunović, Milena and Vuković, Marina",
year = "2017",
abstract = "Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma",
volume = "22",
number = "5",
pages = "1322-1327",
url = "https://hdl.handle.net/21.15107/rcub_smile_2206"
}

Latić, D., Radojević-Škodrić, S., Nikolić, S., Prvanović, M., Lazić, M., Džamić, Z., Bogdanović, L., Radunović, M.,& Vuković, M.. (2017). Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 22(5), 1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206

Latić D, Radojević-Škodrić S, Nikolić S, Prvanović M, Lazić M, Džamić Z, Bogdanović L, Radunović M, Vuković M. Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma. in Journal of BUON. 2017;22(5):1322-1327.
https://hdl.handle.net/21.15107/rcub_smile_2206 .

Latić, Dragana, Radojević-Škodrić, Sanja, Nikolić, Srđan, Prvanović, Mirjana, Lazić, Miodrag, Džamić, Zoran, Bogdanović, Ljiljana, Radunović, Milena, Vuković, Marina, "Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma" in Journal of BUON, 22, no. 5 (2017):1322-1327,
https://hdl.handle.net/21.15107/rcub_smile_2206 .

TY  - JOUR
AU  - Basta-Jovanović, Gordana
AU  - Bogdanović, Ljiljana
AU  - Radunović, Milena
AU  - Prostran, Milica S.
AU  - Naumović, R.
AU  - Simić-Ogrizović, Sanja
AU  - Radojević-Škodrić, Sanja
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2094
AB  - Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation
VL  - 23
IS  - 19
SP  - 2012
EP  - 2017
DO  - 10.2174/092986732319160719192019
ER  - 

@article{
author = "Basta-Jovanović, Gordana and Bogdanović, Ljiljana and Radunović, Milena and Prostran, Milica S. and Naumović, R. and Simić-Ogrizović, Sanja and Radojević-Škodrić, Sanja",
year = "2016",
abstract = "Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation",
volume = "23",
number = "19",
pages = "2012-2017",
doi = "10.2174/092986732319160719192019"
}

Basta-Jovanović, G., Bogdanović, L., Radunović, M., Prostran, M. S., Naumović, R., Simić-Ogrizović, S.,& Radojević-Škodrić, S.. (2016). Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 23(19), 2012-2017.
https://doi.org/10.2174/092986732319160719192019

Basta-Jovanović G, Bogdanović L, Radunović M, Prostran MS, Naumović R, Simić-Ogrizović S, Radojević-Škodrić S. Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry. 2016;23(19):2012-2017.
doi:10.2174/092986732319160719192019 .

Basta-Jovanović, Gordana, Bogdanović, Ljiljana, Radunović, Milena, Prostran, Milica S., Naumović, R., Simić-Ogrizović, Sanja, Radojević-Škodrić, Sanja, "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation" in Current Medicinal Chemistry, 23, no. 19 (2016):2012-2017,
https://doi.org/10.2174/092986732319160719192019 . .

TY  - JOUR
AU  - Radunović, Milena
AU  - Tomanović, Nada
AU  - Novaković, Ivana
AU  - Boričić, Ivan
AU  - Milenković, Sanja
AU  - Dimitrijević, Milovan
AU  - Radojević-Škodrić, Sanja
AU  - Bogdanović, Ljiljana
AU  - Basta-Jovanović, Gordana
PY  - 2016
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2077
AB  - Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.
PB  - Balkan Union of Oncology (B.U.ON.)
T2  - Journal of BUON
T1  - Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer
VL  - 21
IS  - 6
SP  - 1530
EP  - 1536
UR  - https://hdl.handle.net/21.15107/rcub_smile_2077
ER  - 

@article{
author = "Radunović, Milena and Tomanović, Nada and Novaković, Ivana and Boričić, Ivan and Milenković, Sanja and Dimitrijević, Milovan and Radojević-Škodrić, Sanja and Bogdanović, Ljiljana and Basta-Jovanović, Gordana",
year = "2016",
abstract = "Purpose: The purpose of this study was to examine whether cytomegalovirus (CMV) is present in different histological types of salivary gland cancer (SGC) by detecting CMV immediate-early (IE) and early gene products, and to determine the presence of its association with the overexpression of interleukin (IL)-6. Methods: Immunohistochemical analysis of 92 cases of different histological types of SGC was performed to determine the presence of IL-6 and CMV antigen and its intensity in tumor tissue. Twenty samples of normal salivary gland tissue obtained during autopsy served as healthy controls. Results: CMV antigens were not found in healthy acinar tissue of salivary glands, but were expressed in epithelium of salivary gland ducts. Negative expression of CMV an tigens was also found in salivary gland tissue surrounding tumors. On the other hand, CMV was detected in 65/92 SGC cases (70.6%). Higher expression of IL-6 was found in SGC (70.7%) than in normal tissue (20%). There was a high association of CMV antigen presence with the presence of IL-6, and with the IL-6 expression intensity. Conclusions: Positive expression of CMV antigens in a high percentage of SGC cells suggests that it might play an important role in carcino genesis by increasing IL-6 production and leading to inhibition of apoptosis and tumor development.",
publisher = "Balkan Union of Oncology (B.U.ON.)",
journal = "Journal of BUON",
title = "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer",
volume = "21",
number = "6",
pages = "1530-1536",
url = "https://hdl.handle.net/21.15107/rcub_smile_2077"
}

Radunović, M., Tomanović, N., Novaković, I., Boričić, I., Milenković, S., Dimitrijević, M., Radojević-Škodrić, S., Bogdanović, L.,& Basta-Jovanović, G.. (2016). Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON
Balkan Union of Oncology (B.U.ON.)., 21(6), 1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077

Radunović M, Tomanović N, Novaković I, Boričić I, Milenković S, Dimitrijević M, Radojević-Škodrić S, Bogdanović L, Basta-Jovanović G. Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer. in Journal of BUON. 2016;21(6):1530-1536.
https://hdl.handle.net/21.15107/rcub_smile_2077 .

Radunović, Milena, Tomanović, Nada, Novaković, Ivana, Boričić, Ivan, Milenković, Sanja, Dimitrijević, Milovan, Radojević-Škodrić, Sanja, Bogdanović, Ljiljana, Basta-Jovanović, Gordana, "Cytomegalovirus induces Interleukin-6 mediated inflammatory response in salivary gland cancer" in Journal of BUON, 21, no. 6 (2016):1530-1536,
https://hdl.handle.net/21.15107/rcub_smile_2077 .

TY  - JOUR
AU  - Radojević-Škodrić, Sanja
AU  - Basta-Jovanović, Gordana
AU  - Brašanac, Dimitrije
AU  - Nikolić, Nadja
AU  - Bogdanović, Ljiljana
AU  - Miličić, Biljana
AU  - Milašin, Jelena
PY  - 2012
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/1744
AB  - Survivin, an apoptotic inhibitor, is overexpressed in various types of cancer. Mechanisms of survivin upregulation are still poorly understood, but single nucleotide polymorphisms in the survivin gene promoter have been shown to modulate survivin expression and consequently the risk for some types of cancer. The aim of the present study was to investigate whether survivin promoter -31 G/C and -241 C/T polymorphisms could represent susceptibility factors for Wilms tumor (WT) development in Serbian population. Genotype and allele frequencies for the 2 polymorphisms in survivin promoter have been analyzed by polymerase chain reaction/restriction fragment length polymorphism in 59 WT patients and 82 controls. The frequencies of alleles and genotypes were significantly different between patients and controls for the -31 G/C polymorphism. Individuals with CC and CG genotypes had significantly decreased risk of WT compared with GG individuals (odds ratio 0.26, 95% confidence interval, 0.07-0.96; odds ratio 0.30, 95% confidence interval, 0.15-0.60). There was also a statistically significant difference in genotype frequencies between intermediate and high-risk prognostic groups (P = 0.015). The -241 C/T polymorphism did not show association with WT susceptibility. Our findings suggest that the G allele at -31 survivin gene promoter position is associated with a significantly higher cancer risk in Serbian children, with a gene dosage effect.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Pediatric Hematology Oncology
T1  - Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children
VL  - 34
IS  - 8
SP  - E310
EP  - E314
DO  - 10.1097/MPH.0b013e31825d3076
ER  - 

@article{
author = "Radojević-Škodrić, Sanja and Basta-Jovanović, Gordana and Brašanac, Dimitrije and Nikolić, Nadja and Bogdanović, Ljiljana and Miličić, Biljana and Milašin, Jelena",
year = "2012",
abstract = "Survivin, an apoptotic inhibitor, is overexpressed in various types of cancer. Mechanisms of survivin upregulation are still poorly understood, but single nucleotide polymorphisms in the survivin gene promoter have been shown to modulate survivin expression and consequently the risk for some types of cancer. The aim of the present study was to investigate whether survivin promoter -31 G/C and -241 C/T polymorphisms could represent susceptibility factors for Wilms tumor (WT) development in Serbian population. Genotype and allele frequencies for the 2 polymorphisms in survivin promoter have been analyzed by polymerase chain reaction/restriction fragment length polymorphism in 59 WT patients and 82 controls. The frequencies of alleles and genotypes were significantly different between patients and controls for the -31 G/C polymorphism. Individuals with CC and CG genotypes had significantly decreased risk of WT compared with GG individuals (odds ratio 0.26, 95% confidence interval, 0.07-0.96; odds ratio 0.30, 95% confidence interval, 0.15-0.60). There was also a statistically significant difference in genotype frequencies between intermediate and high-risk prognostic groups (P = 0.015). The -241 C/T polymorphism did not show association with WT susceptibility. Our findings suggest that the G allele at -31 survivin gene promoter position is associated with a significantly higher cancer risk in Serbian children, with a gene dosage effect.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Pediatric Hematology Oncology",
title = "Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children",
volume = "34",
number = "8",
pages = "E310-E314",
doi = "10.1097/MPH.0b013e31825d3076"
}

Radojević-Škodrić, S., Basta-Jovanović, G., Brašanac, D., Nikolić, N., Bogdanović, L., Miličić, B.,& Milašin, J.. (2012). Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children. in Journal of Pediatric Hematology Oncology
Lippincott Williams & Wilkins, Philadelphia., 34(8), E310-E314.
https://doi.org/10.1097/MPH.0b013e31825d3076

Radojević-Škodrić S, Basta-Jovanović G, Brašanac D, Nikolić N, Bogdanović L, Miličić B, Milašin J. Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children. in Journal of Pediatric Hematology Oncology. 2012;34(8):E310-E314.
doi:10.1097/MPH.0b013e31825d3076 .

Radojević-Škodrić, Sanja, Basta-Jovanović, Gordana, Brašanac, Dimitrije, Nikolić, Nadja, Bogdanović, Ljiljana, Miličić, Biljana, Milašin, Jelena, "Survivin Gene Promoter -31 G/C Polymorphism Is Associated With Wilms Tumor Susceptibility in Serbian Children" in Journal of Pediatric Hematology Oncology, 34, no. 8 (2012):E310-E314,
https://doi.org/10.1097/MPH.0b013e31825d3076 . .